longtext: 5y2x-pdb

content
HEADER    HYDROLASE                               27-JUL-17   5Y2X
TITLE     CRYSTAL STRUCTURE OF APO-HALOTAG (M175C)
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: HALOALKANE DEHALOGENASE;
COMPND   3 CHAIN: A;
COMPND   4 FRAGMENT: UNP RESIDUES 2-293;
COMPND   5 EC: 3.8.1.5;
COMPND   6 ENGINEERED: YES;
COMPND   7 MUTATION: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: RHODOCOCCUS SP.;
SOURCE   3 ORGANISM_TAXID: 1831;
SOURCE   4 GENE: DHAA;
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3);
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 469008;
SOURCE   7 EXPRESSION_SYSTEM_STRAIN: BL21(DE3)
KEYWDS    HALOTAG, HALOALKANE DEHALOGENASE, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    H.LEE,M.KANG,H.RHEE,C.LEE
REVDAT   1   06-SEP-17 5Y2X    0
JRNL        AUTH   M.G.KANG,H.LEE,B.H.KIM,Y.DUNBAYEV,J.K.SEO,C.LEE,H.W.RHEE
JRNL        TITL   STRUCTURE-GUIDED SYNTHESIS OF A PROTEIN-BASED FLUORESCENT
JRNL        TITL 2 SENSOR FOR ALKYL HALIDES
JRNL        REF    CHEM. COMMUN. (CAMB.)         V.  53  9226 2017
JRNL        REFN                   ESSN 1364-548X
JRNL        PMID   28766590
JRNL        DOI    10.1039/C7CC03714G
REMARK   2
REMARK   2 RESOLUTION.    2.02 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX 1.10.1-2155
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : NULL
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.02
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 34.44
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : NULL
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.9
REMARK   3   NUMBER OF REFLECTIONS             : 22178
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : NULL
REMARK   3   R VALUE            (WORKING SET) : 0.163
REMARK   3   FREE R VALUE                     : 0.192
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : NULL
REMARK   3   FREE R VALUE TEST SET COUNT      : 1109
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : NULL
REMARK   3   SOLVENT RADIUS     : NULL
REMARK   3   SHRINKAGE RADIUS   : NULL
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : NULL
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : NULL
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :   NULL           NULL
REMARK   3   ANGLE     :   NULL           NULL
REMARK   3   CHIRALITY :   NULL           NULL
REMARK   3   PLANARITY :   NULL           NULL
REMARK   3   DIHEDRAL  :   NULL           NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 5Y2X COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 28-JUL-17.
REMARK 100 THE DEPOSITION ID IS D_1300004580.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 14-DEC-15
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : NULL
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : PAL/PLS
REMARK 200  BEAMLINE                       : 7A (6B, 6C1)
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.00000
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 270
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000
REMARK 200  DATA SCALING SOFTWARE          : HKL-2000
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 22255
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.020
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.5
REMARK 200  DATA REDUNDANCY                : 6.100
REMARK 200  R MERGE                    (I) : 0.09400
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 26.4000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : NULL
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : NULL
REMARK 200  COMPLETENESS FOR SHELL     (%) : NULL
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL
REMARK 200  R MERGE FOR SHELL          (I) : 0.33400
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHENIX
REMARK 200 STARTING MODEL: 4KAF
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 48.61
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.39
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 25% PEG 20K, 0.1M TRIS PH 8.2, 200MM
REMARK 280  MGCL2, 5% BUTANOL., VAPOR DIFFUSION, HANGING DROP, TEMPERATURE
REMARK 280  293K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 43 21 2
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,-Y,Z+1/2
REMARK 290       3555   -Y+1/2,X+1/2,Z+3/4
REMARK 290       4555   Y+1/2,-X+1/2,Z+1/4
REMARK 290       5555   -X+1/2,Y+1/2,-Z+3/4
REMARK 290       6555   X+1/2,-Y+1/2,-Z+1/4
REMARK 290       7555   Y,X,-Z
REMARK 290       8555   -Y,-X,-Z+1/2
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       82.09600
REMARK 290   SMTRY1   3  0.000000 -1.000000  0.000000       31.32100
REMARK 290   SMTRY2   3  1.000000  0.000000  0.000000       31.32100
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000      123.14400
REMARK 290   SMTRY1   4  0.000000  1.000000  0.000000       31.32100
REMARK 290   SMTRY2   4 -1.000000  0.000000  0.000000       31.32100
REMARK 290   SMTRY3   4  0.000000  0.000000  1.000000       41.04800
REMARK 290   SMTRY1   5 -1.000000  0.000000  0.000000       31.32100
REMARK 290   SMTRY2   5  0.000000  1.000000  0.000000       31.32100
REMARK 290   SMTRY3   5  0.000000  0.000000 -1.000000      123.14400
REMARK 290   SMTRY1   6  1.000000  0.000000  0.000000       31.32100
REMARK 290   SMTRY2   6  0.000000 -1.000000  0.000000       31.32100
REMARK 290   SMTRY3   6  0.000000  0.000000 -1.000000       41.04800
REMARK 290   SMTRY1   7  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY2   7  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY3   7  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   8  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY2   8 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY3   8  0.000000  0.000000 -1.000000       82.09600
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 140 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 11690 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -12.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     SER A    -1
REMARK 465     GLY A     0
REMARK 465     SER A     1
REMARK 465     ALA A     2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   O    HOH A   556     O    HOH A   609              2.15
REMARK 500   O    HOH A   608     O    HOH A   624              2.18
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS
REMARK 500
REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC
REMARK 500 SYMMETRY ARE IN CLOSE CONTACT.  AN ATOM LOCATED WITHIN 0.15
REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A
REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375
REMARK 500 INSTEAD OF REMARK 500.  ATOMS WITH NON-BLANK ALTERNATE
REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS.
REMARK 500
REMARK 500 DISTANCE CUTOFF:
REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS
REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI  SSYMOP   DISTANCE
REMARK 500   O    HOH A   536     O    HOH A   624     7545     2.19
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    PRO A   9       49.28    -87.92
REMARK 500    PRO A  42       49.71   -106.27
REMARK 500    THR A  43     -160.93   -104.35
REMARK 500    GLU A  98      -86.16   -106.65
REMARK 500    ASP A 106     -132.70     57.65
REMARK 500    ARG A 153       44.28    -86.74
REMARK 500    VAL A 245      -71.99   -135.70
REMARK 500    LEU A 271      -97.45   -119.51
REMARK 500
REMARK 500 REMARK: NULL
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CL A 301
DBREF  5Y2X A    2   293  UNP    P0A3G3   DHAA_RHOSO       2    293
SEQADV 5Y2X SER A   -1  UNP  P0A3G3              EXPRESSION TAG
SEQADV 5Y2X GLY A    0  UNP  P0A3G3              EXPRESSION TAG
SEQADV 5Y2X SER A    1  UNP  P0A3G3              EXPRESSION TAG
SEQADV 5Y2X ALA A    2  UNP  P0A3G3    SER     2 ENGINEERED MUTATION
SEQADV 5Y2X VAL A   47  UNP  P0A3G3    LEU    47 ENGINEERED MUTATION
SEQADV 5Y2X THR A   58  UNP  P0A3G3    SER    58 ENGINEERED MUTATION
SEQADV 5Y2X GLY A   78  UNP  P0A3G3    ASP    78 ENGINEERED MUTATION
SEQADV 5Y2X PHE A   87  UNP  P0A3G3    TYR    87 ENGINEERED MUTATION
SEQADV 5Y2X MET A   88  UNP  P0A3G3    LEU    88 ENGINEERED MUTATION
SEQADV 5Y2X PHE A  128  UNP  P0A3G3    CYS   128 ENGINEERED MUTATION
SEQADV 5Y2X THR A  155  UNP  P0A3G3    ALA   155 ENGINEERED MUTATION
SEQADV 5Y2X LYS A  160  UNP  P0A3G3    GLU   160 ENGINEERED MUTATION
SEQADV 5Y2X VAL A  167  UNP  P0A3G3    ALA   167 ENGINEERED MUTATION
SEQADV 5Y2X THR A  172  UNP  P0A3G3    ALA   172 ENGINEERED MUTATION
SEQADV 5Y2X CYS A  175  UNP  P0A3G3    LYS   175 ENGINEERED MUTATION
SEQADV 5Y2X GLY A  176  UNP  P0A3G3    CYS   176 ENGINEERED MUTATION
SEQADV 5Y2X ASN A  195  UNP  P0A3G3    LYS   195 ENGINEERED MUTATION
SEQADV 5Y2X GLU A  224  UNP  P0A3G3    ALA   224 ENGINEERED MUTATION
SEQADV 5Y2X ASP A  227  UNP  P0A3G3    ASN   227 ENGINEERED MUTATION
SEQADV 5Y2X LYS A  257  UNP  P0A3G3    GLU   257 ENGINEERED MUTATION
SEQADV 5Y2X ALA A  264  UNP  P0A3G3    THR   264 ENGINEERED MUTATION
SEQADV 5Y2X ASN A  272  UNP  P0A3G3    HIS   272 ENGINEERED MUTATION
SEQADV 5Y2X LEU A  273  UNP  P0A3G3    TYR   273 ENGINEERED MUTATION
SEQADV 5Y2X SER A  291  UNP  P0A3G3    PRO   291 ENGINEERED MUTATION
SEQADV 5Y2X THR A  292  UNP  P0A3G3    ALA   292 ENGINEERED MUTATION
SEQADV 5Y2X GLU A  294  UNP  P0A3G3              EXPRESSION TAG
SEQADV 5Y2X ILE A  295  UNP  P0A3G3              EXPRESSION TAG
SEQADV 5Y2X SER A  296  UNP  P0A3G3              EXPRESSION TAG
SEQADV 5Y2X GLY A  297  UNP  P0A3G3              EXPRESSION TAG
SEQRES   1 A  299  SER GLY SER ALA GLU ILE GLY THR GLY PHE PRO PHE ASP
SEQRES   2 A  299  PRO HIS TYR VAL GLU VAL LEU GLY GLU ARG MET HIS TYR
SEQRES   3 A  299  VAL ASP VAL GLY PRO ARG ASP GLY THR PRO VAL LEU PHE
SEQRES   4 A  299  LEU HIS GLY ASN PRO THR SER SER TYR VAL TRP ARG ASN
SEQRES   5 A  299  ILE ILE PRO HIS VAL ALA PRO THR HIS ARG CYS ILE ALA
SEQRES   6 A  299  PRO ASP LEU ILE GLY MET GLY LYS SER ASP LYS PRO ASP
SEQRES   7 A  299  LEU GLY TYR PHE PHE ASP ASP HIS VAL ARG PHE MET ASP
SEQRES   8 A  299  ALA PHE ILE GLU ALA LEU GLY LEU GLU GLU VAL VAL LEU
SEQRES   9 A  299  VAL ILE HIS ASP TRP GLY SER ALA LEU GLY PHE HIS TRP
SEQRES  10 A  299  ALA LYS ARG ASN PRO GLU ARG VAL LYS GLY ILE ALA PHE
SEQRES  11 A  299  MET GLU PHE ILE ARG PRO ILE PRO THR TRP ASP GLU TRP
SEQRES  12 A  299  PRO GLU PHE ALA ARG GLU THR PHE GLN ALA PHE ARG THR
SEQRES  13 A  299  THR ASP VAL GLY ARG LYS LEU ILE ILE ASP GLN ASN VAL
SEQRES  14 A  299  PHE ILE GLU GLY THR LEU PRO CYS GLY VAL VAL ARG PRO
SEQRES  15 A  299  LEU THR GLU VAL GLU MET ASP HIS TYR ARG GLU PRO PHE
SEQRES  16 A  299  LEU ASN PRO VAL ASP ARG GLU PRO LEU TRP ARG PHE PRO
SEQRES  17 A  299  ASN GLU LEU PRO ILE ALA GLY GLU PRO ALA ASN ILE VAL
SEQRES  18 A  299  ALA LEU VAL GLU GLU TYR MET ASP TRP LEU HIS GLN SER
SEQRES  19 A  299  PRO VAL PRO LYS LEU LEU PHE TRP GLY THR PRO GLY VAL
SEQRES  20 A  299  LEU ILE PRO PRO ALA GLU ALA ALA ARG LEU ALA LYS SER
SEQRES  21 A  299  LEU PRO ASN CYS LYS ALA VAL ASP ILE GLY PRO GLY LEU
SEQRES  22 A  299  ASN LEU LEU GLN GLU ASP ASN PRO ASP LEU ILE GLY SER
SEQRES  23 A  299  GLU ILE ALA ARG TRP LEU SER THR LEU GLU ILE SER GLY
HET     CL  A 301       1
HETNAM      CL CHLORIDE ION
FORMUL   2   CL    CL 1-
FORMUL   3  HOH   *259(H2 O)
HELIX    1 AA1 SER A   44  ARG A   49  5                                   6
HELIX    2 AA2 ILE A   51  ALA A   56  1                                   6
HELIX    3 AA3 PHE A   80  LEU A   95  1                                  16
HELIX    4 AA4 ASP A  106  ASN A  119  1                                  14
HELIX    5 AA5 THR A  137  TRP A  141  5                                   5
HELIX    6 AA6 PRO A  142  PHE A  144  5                                   3
HELIX    7 AA7 ALA A  145  ARG A  153  1                                   9
HELIX    8 AA8 THR A  155  ILE A  163  1                                   9
HELIX    9 AA9 ASN A  166  GLY A  171  1                                   6
HELIX   10 AB1 LEU A  173  VAL A  177  5                                   5
HELIX   11 AB2 THR A  182  GLU A  191  1                                  10
HELIX   12 AB3 PRO A  192  LEU A  194  5                                   3
HELIX   13 AB4 ASN A  195  ASP A  198  5                                   4
HELIX   14 AB5 ARG A  199  LEU A  209  1                                  11
HELIX   15 AB6 PRO A  215  SER A  232  1                                  18
HELIX   16 AB7 PRO A  248  LEU A  259  1                                  12
HELIX   17 AB8 LEU A  273  ASN A  278  1                                   6
HELIX   18 AB9 ASN A  278  LEU A  293  1                                  16
SHEET    1 AA1 8 HIS A  13  VAL A  17  0
SHEET    2 AA1 8 GLU A  20  VAL A  27 -1  O  GLU A  20   N  VAL A  17
SHEET    3 AA1 8 CYS A  61  PRO A  64 -1  O  CYS A  61   N  VAL A  27
SHEET    4 AA1 8 VAL A  35  LEU A  38  1  N  PHE A  37   O  ILE A  62
SHEET    5 AA1 8 VAL A 100  HIS A 105  1  O  VAL A 103   N  LEU A  36
SHEET    6 AA1 8 VAL A 123  MET A 129  1  O  ALA A 127   N  LEU A 102
SHEET    7 AA1 8 LYS A 236  PRO A 243  1  O  LEU A 237   N  PHE A 128
SHEET    8 AA1 8 CYS A 262  GLY A 270  1  O  VAL A 265   N  LEU A 238
CISPEP   1 ASN A   41    PRO A   42          0        -0.94
CISPEP   2 GLU A  214    PRO A  215          0        -5.60
CISPEP   3 THR A  242    PRO A  243          0         2.03
SITE     1 AC1  3 ASN A  41  TRP A 107  PRO A 206
CRYST1   62.642   62.642  164.192  90.00  90.00  90.00 P 43 21 2     8
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.015964  0.000000  0.000000        0.00000
SCALE2      0.000000  0.015964  0.000000        0.00000
SCALE3      0.000000  0.000000  0.006090        0.00000
TER    2366      GLY A 297
MASTER      279    0    1   18    8    0    1    6 2622    1    0   23
END