longtext: 5y57-pdb

content
HEADER    HYDROLASE                               07-AUG-17   5Y57
TITLE     CRYSTAL STRUCTURE OF A NOVEL PYRETHROID HYDROLASE FROM SPHINGOBIUM
TITLE    2 FANIAE JZ-2
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: PYRETHROID HYDROLASE;
COMPND   3 CHAIN: A, B, C, D, E, F;
COMPND   4 FRAGMENT: UNP RESIDUES 2-280;
COMPND   5 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: SPHINGOBIUM FANIAE;
SOURCE   3 ORGANISM_TAXID: 570446;
SOURCE   4 GENE: PYTH;
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 562
KEYWDS    HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    D.Q.XU,T.T.RAN,J.HE,W.W.WANG
REVDAT   1   08-AUG-18 5Y57    0
JRNL        AUTH   D.Q.XU,T.T.RAN,J.HE,W.W.WANG
JRNL        TITL   STRUCTURE AND CATALYTIC MECHANISM OF A NOVEL PYRETHROID
JRNL        TITL 2 HYDROLASE FROM SPHINGOBIUM FANIAE JZ-2
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   2
REMARK   2 RESOLUTION.    1.96 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX (DEV_2247: ???)
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : ML
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.96
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 19.85
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.330
REMARK   3   COMPLETENESS FOR RANGE        (%) : 98.9
REMARK   3   NUMBER OF REFLECTIONS             : 125199
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.258
REMARK   3   R VALUE            (WORKING SET) : 0.255
REMARK   3   FREE R VALUE                     : 0.309
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.010
REMARK   3   FREE R VALUE TEST SET COUNT      : 6268
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 19.8534 -  6.0372    1.00     4313   221  0.1806 0.2021
REMARK   3     2  6.0372 -  4.8144    1.00     4156   206  0.1966 0.2108
REMARK   3     3  4.8144 -  4.2125    1.00     4041   266  0.1875 0.2526
REMARK   3     4  4.2125 -  3.8303    1.00     4094   197  0.2018 0.2664
REMARK   3     5  3.8303 -  3.5575    1.00     4061   207  0.2266 0.2874
REMARK   3     6  3.5575 -  3.3488    1.00     4052   205  0.2378 0.3119
REMARK   3     7  3.3488 -  3.1818    1.00     4013   211  0.2467 0.2852
REMARK   3     8  3.1818 -  3.0438    1.00     4028   221  0.2569 0.3300
REMARK   3     9  3.0438 -  2.9270    1.00     4001   231  0.2794 0.3639
REMARK   3    10  2.9270 -  2.8263    1.00     3982   218  0.2862 0.3478
REMARK   3    11  2.8263 -  2.7381    1.00     3985   223  0.2913 0.3384
REMARK   3    12  2.7381 -  2.6601    1.00     4000   223  0.2948 0.3718
REMARK   3    13  2.6601 -  2.5902    1.00     4003   198  0.3019 0.3387
REMARK   3    14  2.5902 -  2.5271    1.00     4008   193  0.2931 0.3531
REMARK   3    15  2.5271 -  2.4698    1.00     3989   219  0.2940 0.3655
REMARK   3    16  2.4698 -  2.4173    1.00     3968   218  0.2985 0.3575
REMARK   3    17  2.4173 -  2.3690    1.00     3980   220  0.3196 0.3950
REMARK   3    18  2.3690 -  2.3244    1.00     3984   217  0.3158 0.3847
REMARK   3    19  2.3244 -  2.2829    1.00     3982   204  0.3106 0.3572
REMARK   3    20  2.2829 -  2.2443    1.00     3969   200  0.3188 0.4050
REMARK   3    21  2.2443 -  2.2081    1.00     3966   223  0.3179 0.3443
REMARK   3    22  2.2081 -  2.1742    1.00     3994   194  0.3217 0.3951
REMARK   3    23  2.1742 -  2.1423    1.00     3965   206  0.3276 0.3587
REMARK   3    24  2.1423 -  2.1121    1.00     3967   203  0.3458 0.4023
REMARK   3    25  2.1121 -  2.0836    1.00     3974   224  0.3365 0.3869
REMARK   3    26  2.0836 -  2.0566    1.00     3953   202  0.3469 0.3714
REMARK   3    27  2.0566 -  2.0309    1.00     3949   204  0.3529 0.4003
REMARK   3    28  2.0309 -  2.0065    0.99     3989   163  0.3576 0.4090
REMARK   3    29  2.0065 -  1.9832    0.99     3870   220  0.3790 0.4039
REMARK   3    30  1.9832 -  1.9609    0.68     2695   131  0.4222 0.5048
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL
REMARK   3   SOLVENT RADIUS     : 1.11
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.390
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 36.470
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :  0.009          11935
REMARK   3   ANGLE     :  1.127          16357
REMARK   3   CHIRALITY :  0.058           1815
REMARK   3   PLANARITY :  0.008           2184
REMARK   3   DIHEDRAL  : 18.094           7105
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 5Y57 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 09-AUG-17.
REMARK 100 THE DEPOSITION ID IS D_1300004681.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 12-JUL-13
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 7.5
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : SSRF
REMARK 200  BEAMLINE                       : BL17U1
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9792
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 315R
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200  DATA SCALING SOFTWARE          : SCALA
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 125394
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.960
REMARK 200  RESOLUTION RANGE LOW       (A) : 20.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 1.200
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 98.9
REMARK 200  DATA REDUNDANCY                : 11.70
REMARK 200  R MERGE                    (I) : NULL
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 9.2000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.96
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.07
REMARK 200  COMPLETENESS FOR SHELL     (%) : 92.9
REMARK 200  DATA REDUNDANCY IN SHELL       : 8.50
REMARK 200  R MERGE FOR SHELL          (I) : NULL
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 47.08
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.32
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: AMMONIUM SULFATE, PH 7.5, VAPOR
REMARK 280  DIFFUSION, SITTING DROP, TEMPERATURE 293K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 42 21 2
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,-Y,Z
REMARK 290       3555   -Y+1/2,X+1/2,Z+1/2
REMARK 290       4555   Y+1/2,-X+1/2,Z+1/2
REMARK 290       5555   -X+1/2,Y+1/2,-Z+1/2
REMARK 290       6555   X+1/2,-Y+1/2,-Z+1/2
REMARK 290       7555   Y,X,-Z
REMARK 290       8555   -Y,-X,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   3  0.000000 -1.000000  0.000000       84.22650
REMARK 290   SMTRY2   3  1.000000  0.000000  0.000000       84.22650
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000       61.79650
REMARK 290   SMTRY1   4  0.000000  1.000000  0.000000       84.22650
REMARK 290   SMTRY2   4 -1.000000  0.000000  0.000000       84.22650
REMARK 290   SMTRY3   4  0.000000  0.000000  1.000000       61.79650
REMARK 290   SMTRY1   5 -1.000000  0.000000  0.000000       84.22650
REMARK 290   SMTRY2   5  0.000000  1.000000  0.000000       84.22650
REMARK 290   SMTRY3   5  0.000000  0.000000 -1.000000       61.79650
REMARK 290   SMTRY1   6  1.000000  0.000000  0.000000       84.22650
REMARK 290   SMTRY2   6  0.000000 -1.000000  0.000000       84.22650
REMARK 290   SMTRY3   6  0.000000  0.000000 -1.000000       61.79650
REMARK 290   SMTRY1   7  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY2   7  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY3   7  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   8  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY2   8 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY3   8  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2, 3, 4, 5, 6
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 3
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 4
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: D
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 5
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: E
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 6
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: F
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MSE A     1
REMARK 465     GLU A   162
REMARK 465     GLY A   163
REMARK 465     ARG A   255
REMARK 465     GLN A   256
REMARK 465     THR A   257
REMARK 465     ALA A   258
REMARK 465     THR A   259
REMARK 465     LYS A   260
REMARK 465     ALA A   261
REMARK 465     GLY A   262
REMARK 465     PRO A   263
REMARK 465     ASP A   264
REMARK 465     ARG A   265
REMARK 465     PRO A   266
REMARK 465     ALA A   267
REMARK 465     GLY A   268
REMARK 465     ALA A   269
REMARK 465     ASP A   270
REMARK 465     GLY A   271
REMARK 465     GLY A   272
REMARK 465     ARG A   273
REMARK 465     ALA A   274
REMARK 465     ASP A   275
REMARK 465     ARG A   276
REMARK 465     ALA A   277
REMARK 465     ASP A   278
REMARK 465     LEU A   279
REMARK 465     PRO A   280
REMARK 465     LEU A   281
REMARK 465     GLU A   282
REMARK 465     HIS A   283
REMARK 465     HIS A   284
REMARK 465     HIS A   285
REMARK 465     HIS A   286
REMARK 465     HIS A   287
REMARK 465     HIS A   288
REMARK 465     MSE B     1
REMARK 465     GLU B   162
REMARK 465     ARG B   255
REMARK 465     GLN B   256
REMARK 465     THR B   257
REMARK 465     ALA B   258
REMARK 465     THR B   259
REMARK 465     LYS B   260
REMARK 465     ALA B   261
REMARK 465     GLY B   262
REMARK 465     PRO B   263
REMARK 465     ASP B   264
REMARK 465     ARG B   265
REMARK 465     PRO B   266
REMARK 465     ALA B   267
REMARK 465     GLY B   268
REMARK 465     ALA B   269
REMARK 465     ASP B   270
REMARK 465     GLY B   271
REMARK 465     GLY B   272
REMARK 465     ARG B   273
REMARK 465     ALA B   274
REMARK 465     ASP B   275
REMARK 465     ARG B   276
REMARK 465     ALA B   277
REMARK 465     ASP B   278
REMARK 465     LEU B   279
REMARK 465     PRO B   280
REMARK 465     LEU B   281
REMARK 465     GLU B   282
REMARK 465     HIS B   283
REMARK 465     HIS B   284
REMARK 465     HIS B   285
REMARK 465     HIS B   286
REMARK 465     HIS B   287
REMARK 465     HIS B   288
REMARK 465     MSE C     1
REMARK 465     ARG C   255
REMARK 465     GLN C   256
REMARK 465     THR C   257
REMARK 465     ALA C   258
REMARK 465     THR C   259
REMARK 465     LYS C   260
REMARK 465     ALA C   261
REMARK 465     GLY C   262
REMARK 465     PRO C   263
REMARK 465     ASP C   264
REMARK 465     ARG C   265
REMARK 465     PRO C   266
REMARK 465     ALA C   267
REMARK 465     GLY C   268
REMARK 465     ALA C   269
REMARK 465     ASP C   270
REMARK 465     GLY C   271
REMARK 465     GLY C   272
REMARK 465     ARG C   273
REMARK 465     ALA C   274
REMARK 465     ASP C   275
REMARK 465     ARG C   276
REMARK 465     ALA C   277
REMARK 465     ASP C   278
REMARK 465     LEU C   279
REMARK 465     PRO C   280
REMARK 465     LEU C   281
REMARK 465     GLU C   282
REMARK 465     HIS C   283
REMARK 465     HIS C   284
REMARK 465     HIS C   285
REMARK 465     HIS C   286
REMARK 465     HIS C   287
REMARK 465     HIS C   288
REMARK 465     MSE D     1
REMARK 465     GLU D   162
REMARK 465     ARG D   255
REMARK 465     GLN D   256
REMARK 465     THR D   257
REMARK 465     ALA D   258
REMARK 465     THR D   259
REMARK 465     LYS D   260
REMARK 465     ALA D   261
REMARK 465     GLY D   262
REMARK 465     PRO D   263
REMARK 465     ASP D   264
REMARK 465     ARG D   265
REMARK 465     PRO D   266
REMARK 465     ALA D   267
REMARK 465     GLY D   268
REMARK 465     ALA D   269
REMARK 465     ASP D   270
REMARK 465     GLY D   271
REMARK 465     GLY D   272
REMARK 465     ARG D   273
REMARK 465     ALA D   274
REMARK 465     ASP D   275
REMARK 465     ARG D   276
REMARK 465     ALA D   277
REMARK 465     ASP D   278
REMARK 465     LEU D   279
REMARK 465     PRO D   280
REMARK 465     LEU D   281
REMARK 465     GLU D   282
REMARK 465     HIS D   283
REMARK 465     HIS D   284
REMARK 465     HIS D   285
REMARK 465     HIS D   286
REMARK 465     HIS D   287
REMARK 465     HIS D   288
REMARK 465     MSE E     1
REMARK 465     GLU E   162
REMARK 465     GLY E   163
REMARK 465     ARG E   255
REMARK 465     GLN E   256
REMARK 465     THR E   257
REMARK 465     ALA E   258
REMARK 465     THR E   259
REMARK 465     LYS E   260
REMARK 465     ALA E   261
REMARK 465     GLY E   262
REMARK 465     PRO E   263
REMARK 465     ASP E   264
REMARK 465     ARG E   265
REMARK 465     PRO E   266
REMARK 465     ALA E   267
REMARK 465     GLY E   268
REMARK 465     ALA E   269
REMARK 465     ASP E   270
REMARK 465     GLY E   271
REMARK 465     GLY E   272
REMARK 465     ARG E   273
REMARK 465     ALA E   274
REMARK 465     ASP E   275
REMARK 465     ARG E   276
REMARK 465     ALA E   277
REMARK 465     ASP E   278
REMARK 465     LEU E   279
REMARK 465     PRO E   280
REMARK 465     LEU E   281
REMARK 465     GLU E   282
REMARK 465     HIS E   283
REMARK 465     HIS E   284
REMARK 465     HIS E   285
REMARK 465     HIS E   286
REMARK 465     HIS E   287
REMARK 465     HIS E   288
REMARK 465     MSE F     1
REMARK 465     ARG F   255
REMARK 465     GLN F   256
REMARK 465     THR F   257
REMARK 465     ALA F   258
REMARK 465     THR F   259
REMARK 465     LYS F   260
REMARK 465     ALA F   261
REMARK 465     GLY F   262
REMARK 465     PRO F   263
REMARK 465     ASP F   264
REMARK 465     ARG F   265
REMARK 465     PRO F   266
REMARK 465     ALA F   267
REMARK 465     GLY F   268
REMARK 465     ALA F   269
REMARK 465     ASP F   270
REMARK 465     GLY F   271
REMARK 465     GLY F   272
REMARK 465     ARG F   273
REMARK 465     ALA F   274
REMARK 465     ASP F   275
REMARK 465     ARG F   276
REMARK 465     ALA F   277
REMARK 465     ASP F   278
REMARK 465     LEU F   279
REMARK 465     PRO F   280
REMARK 465     LEU F   281
REMARK 465     GLU F   282
REMARK 465     HIS F   283
REMARK 465     HIS F   284
REMARK 465     HIS F   285
REMARK 465     HIS F   286
REMARK 465     HIS F   287
REMARK 465     HIS F   288
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     ARG C  32    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ARG E  59    CG   CD   NE   CZ   NH1  NH2
REMARK 470     GLU E  69    CG   CD   OE1  OE2
REMARK 470     ASP E  93    CG   OD1  OD2
REMARK 470     LYS E 215    CG   CD   CE   NZ
REMARK 470     ARG F  32    CG   CD   NE   CZ   NH1  NH2
REMARK 470     LYS F  94    CG   CD   CE   NZ
REMARK 470     VAL F 135    CG1  CG2
REMARK 470     GLU F 137    CG   CD   OE1  OE2
REMARK 470     ARG F 139    CG   CD   NE   CZ   NH1  NH2
REMARK 470     GLU F 162    CG   CD   OE1  OE2
REMARK 470     GLU F 186    CG   CD   OE1  OE2
REMARK 470     ARG F 188    CG   CD   NE   CZ   NH1  NH2
REMARK 470     LEU F 190    CG   CD1  CD2
REMARK 470     GLU F 191    CG   CD   OE1  OE2
REMARK 470     ARG F 194    CG   CD   NE   CZ   NH1  NH2
REMARK 470     TYR F 254    CG   CD1  CD2  CE1  CE2  CZ   OH
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   O    GLY F   138     OG1  THR F   176              1.65
REMARK 500   O    HOH A   445     O    HOH A   495              2.04
REMARK 500   O    HOH D   437     O    HOH D   497              2.07
REMARK 500   ND1  HIS C    48     O    HOH C   401              2.15
REMARK 500   O    ASP C    37     O    HOH C   402              2.15
REMARK 500   O    HOH A   496     O    HOH A   504              2.17
REMARK 500   O    LEU E     8     O    HOH E   401              2.17
REMARK 500   OH   TYR C    31     OD1  ASP C   249              2.18
REMARK 500   N    ARG D   150     O    HOH D   401              2.19
REMARK 500   N    GLY D   163     O    HOH D   402              2.19
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS
REMARK 500
REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC
REMARK 500 SYMMETRY ARE IN CLOSE CONTACT.  AN ATOM LOCATED WITHIN 0.15
REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A
REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375
REMARK 500 INSTEAD OF REMARK 500.  ATOMS WITH NON-BLANK ALTERNATE
REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS.
REMARK 500
REMARK 500 DISTANCE CUTOFF:
REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS
REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI  SSYMOP   DISTANCE
REMARK 500   O    HOH A   449     O    HOH C   479     3555     2.17
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    ARG A  29        4.77    -68.13
REMARK 500    SER A  78     -121.54     55.24
REMARK 500    SER A  78     -125.87     56.49
REMARK 500    THR A 102       59.76     25.53
REMARK 500    PRO A 227       49.34    -79.88
REMARK 500    SER A 229     -144.36    -98.01
REMARK 500    ALA A 250       75.78   -166.87
REMARK 500    GLU A 253      -72.23    -70.29
REMARK 500    LEU B  13        9.12     58.39
REMARK 500    SER B  78     -118.53     54.56
REMARK 500    SER B  78     -108.53     37.02
REMARK 500    THR B 102       57.59     29.16
REMARK 500    THR B 125       69.85   -113.24
REMARK 500    SER B 229     -149.70    -87.78
REMARK 500    ALA B 250       82.80   -166.67
REMARK 500    LEU C  13       14.41     57.75
REMARK 500    SER C  78     -121.62     52.46
REMARK 500    SER C  78     -128.58     57.46
REMARK 500    ASP C  93        0.32    -64.64
REMARK 500    THR C 102       53.09     30.36
REMARK 500    THR C 125       66.36   -110.62
REMARK 500    GLU C 186      139.38   -170.24
REMARK 500    SER C 229     -145.97    -82.96
REMARK 500    ALA C 250       92.51   -164.25
REMARK 500    SER D  78     -120.48     45.85
REMARK 500    SER D  78     -127.14     56.22
REMARK 500    THR D 102       60.61     29.78
REMARK 500    THR D 125       74.33   -118.12
REMARK 500    GLU D 186      141.70   -173.21
REMARK 500    SER D 229     -151.32    -92.52
REMARK 500    MSE D 236       69.09   -153.30
REMARK 500    ALA D 250       82.59   -162.47
REMARK 500    LEU E  13       -0.02     66.21
REMARK 500    ASP E  53     -167.40   -164.59
REMARK 500    PRO E  60      -19.23    -44.55
REMARK 500    SER E  78     -115.74     49.12
REMARK 500    SER E  78     -127.20     59.52
REMARK 500    THR E 102       62.55     30.20
REMARK 500    PRO E 227       50.47    -69.37
REMARK 500    SER E 229     -151.09    -82.11
REMARK 500    ALA E 231       74.40   -118.45
REMARK 500    ASP E 249      -70.16    -56.05
REMARK 500    THR F   4      -33.10   -134.58
REMARK 500    LEU F  13       -1.42     76.05
REMARK 500    CYS F  18        5.51    -64.25
REMARK 500    VAL F  52      -87.08   -118.25
REMARK 500    SER F  78     -126.67     61.78
REMARK 500    SER F  78     -129.64     56.46
REMARK 500    THR F 102       56.07     27.49
REMARK 500    ASN F 122       73.80     59.83
REMARK 500
REMARK 500 THIS ENTRY HAS      54 RAMACHANDRAN OUTLIERS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 525
REMARK 525 SOLVENT
REMARK 525
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 525 NUMBER; I=INSERTION CODE):
REMARK 525
REMARK 525  M RES CSSEQI
REMARK 525    HOH A 505        DISTANCE =  5.98 ANGSTROMS
REMARK 525    HOH C 485        DISTANCE =  6.88 ANGSTROMS
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue PMS A 301
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue SO4 A 302
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue SO4 B 302
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue SO4 C 302
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue SO4 D 302
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue SO4 E 302
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue SO4 F 302
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for Di-peptide PMS B 301 and SER B
REMARK 800  78
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for Di-peptide PMS C 301 and SER C
REMARK 800  78
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for Di-peptide PMS C 301 and SER C
REMARK 800  78
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for Di-peptide PMS D 301 and SER D
REMARK 800  78
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for Di-peptide PMS D 301 and SER D
REMARK 800  78
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for Di-peptide PMS E 301 and SER E
REMARK 800  78
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for Di-peptide PMS F 301 and SER F
REMARK 800  78
DBREF  5Y57 A    2   280  UNP    D0VUS3   D0VUS3_9SPHN     2    280
DBREF  5Y57 B    2   280  UNP    D0VUS3   D0VUS3_9SPHN     2    280
DBREF  5Y57 C    2   280  UNP    D0VUS3   D0VUS3_9SPHN     2    280
DBREF  5Y57 D    2   280  UNP    D0VUS3   D0VUS3_9SPHN     2    280
DBREF  5Y57 E    2   280  UNP    D0VUS3   D0VUS3_9SPHN     2    280
DBREF  5Y57 F    2   280  UNP    D0VUS3   D0VUS3_9SPHN     2    280
SEQADV 5Y57 MSE A    1  UNP  D0VUS3              INITIATING METHIONINE
SEQADV 5Y57 LEU A  281  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 GLU A  282  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 HIS A  283  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 HIS A  284  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 HIS A  285  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 HIS A  286  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 HIS A  287  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 HIS A  288  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 MSE B    1  UNP  D0VUS3              INITIATING METHIONINE
SEQADV 5Y57 LEU B  281  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 GLU B  282  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 HIS B  283  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 HIS B  284  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 HIS B  285  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 HIS B  286  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 HIS B  287  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 HIS B  288  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 MSE C    1  UNP  D0VUS3              INITIATING METHIONINE
SEQADV 5Y57 LEU C  281  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 GLU C  282  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 HIS C  283  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 HIS C  284  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 HIS C  285  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 HIS C  286  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 HIS C  287  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 HIS C  288  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 MSE D    1  UNP  D0VUS3              INITIATING METHIONINE
SEQADV 5Y57 LEU D  281  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 GLU D  282  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 HIS D  283  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 HIS D  284  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 HIS D  285  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 HIS D  286  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 HIS D  287  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 HIS D  288  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 MSE E    1  UNP  D0VUS3              INITIATING METHIONINE
SEQADV 5Y57 LEU E  281  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 GLU E  282  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 HIS E  283  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 HIS E  284  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 HIS E  285  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 HIS E  286  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 HIS E  287  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 HIS E  288  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 MSE F    1  UNP  D0VUS3              INITIATING METHIONINE
SEQADV 5Y57 LEU F  281  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 GLU F  282  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 HIS F  283  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 HIS F  284  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 HIS F  285  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 HIS F  286  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 HIS F  287  UNP  D0VUS3              EXPRESSION TAG
SEQADV 5Y57 HIS F  288  UNP  D0VUS3              EXPRESSION TAG
SEQRES   1 A  288  MSE THR VAL THR ASP ILE ILE LEU ILE HIS GLY ALA LEU
SEQRES   2 A  288  ASN ARG GLY ALA CYS TYR ASP ALA VAL VAL PRO LEU LEU
SEQRES   3 A  288  GLU ALA ARG GLY TYR ARG VAL HIS ALA PRO ASP LEU THR
SEQRES   4 A  288  GLY HIS THR PRO GLY ASP GLY GLY HIS LEU SER VAL VAL
SEQRES   5 A  288  ASP MSE GLU HIS TYR THR ARG PRO VAL ALA ASP ILE LEU
SEQRES   6 A  288  ALA ARG ALA GLU GLY GLN SER ILE LEU LEU GLY HIS SER
SEQRES   7 A  288  LEU GLY GLY ALA SER ILE SER TRP LEU ALA GLN HIS HIS
SEQRES   8 A  288  PRO ASP LYS VAL ALA GLY LEU ILE TYR LEU THR ALA VAL
SEQRES   9 A  288  LEU THR ALA PRO GLY VAL THR PRO GLU THR PHE VAL LEU
SEQRES  10 A  288  PRO GLY GLU PRO ASN ARG GLY THR PRO HIS ALA LEU ASP
SEQRES  11 A  288  LEU ILE GLN PRO VAL ASP GLU GLY ARG GLY LEU GLN ALA
SEQRES  12 A  288  ASP PHE SER ARG LEU GLU ARG LEU ARG GLU VAL PHE MSE
SEQRES  13 A  288  GLY ASP TYR PRO GLY GLU GLY MSE PRO PRO ALA GLU HIS
SEQRES  14 A  288  PHE ILE GLN THR GLN SER THR VAL PRO PHE GLY THR PRO
SEQRES  15 A  288  ASN PRO MSE GLU GLY ARG ALA LEU GLU ILE PRO ARG LEU
SEQRES  16 A  288  TYR ILE GLU ALA LEU ASP ASP VAL VAL LEU PRO ILE ALA
SEQRES  17 A  288  VAL GLN ARG GLN MSE GLN LYS GLU PHE PRO GLY PRO VAL
SEQRES  18 A  288  ALA VAL VAL SER LEU PRO ALA SER HIS ALA PRO TYR TYR
SEQRES  19 A  288  SER MSE PRO GLU ARG LEU ALA GLU ALA ILE ALA ASP PHE
SEQRES  20 A  288  ALA ASP ALA PRO ALA GLU TYR ARG GLN THR ALA THR LYS
SEQRES  21 A  288  ALA GLY PRO ASP ARG PRO ALA GLY ALA ASP GLY GLY ARG
SEQRES  22 A  288  ALA ASP ARG ALA ASP LEU PRO LEU GLU HIS HIS HIS HIS
SEQRES  23 A  288  HIS HIS
SEQRES   1 B  288  MSE THR VAL THR ASP ILE ILE LEU ILE HIS GLY ALA LEU
SEQRES   2 B  288  ASN ARG GLY ALA CYS TYR ASP ALA VAL VAL PRO LEU LEU
SEQRES   3 B  288  GLU ALA ARG GLY TYR ARG VAL HIS ALA PRO ASP LEU THR
SEQRES   4 B  288  GLY HIS THR PRO GLY ASP GLY GLY HIS LEU SER VAL VAL
SEQRES   5 B  288  ASP MSE GLU HIS TYR THR ARG PRO VAL ALA ASP ILE LEU
SEQRES   6 B  288  ALA ARG ALA GLU GLY GLN SER ILE LEU LEU GLY HIS SER
SEQRES   7 B  288  LEU GLY GLY ALA SER ILE SER TRP LEU ALA GLN HIS HIS
SEQRES   8 B  288  PRO ASP LYS VAL ALA GLY LEU ILE TYR LEU THR ALA VAL
SEQRES   9 B  288  LEU THR ALA PRO GLY VAL THR PRO GLU THR PHE VAL LEU
SEQRES  10 B  288  PRO GLY GLU PRO ASN ARG GLY THR PRO HIS ALA LEU ASP
SEQRES  11 B  288  LEU ILE GLN PRO VAL ASP GLU GLY ARG GLY LEU GLN ALA
SEQRES  12 B  288  ASP PHE SER ARG LEU GLU ARG LEU ARG GLU VAL PHE MSE
SEQRES  13 B  288  GLY ASP TYR PRO GLY GLU GLY MSE PRO PRO ALA GLU HIS
SEQRES  14 B  288  PHE ILE GLN THR GLN SER THR VAL PRO PHE GLY THR PRO
SEQRES  15 B  288  ASN PRO MSE GLU GLY ARG ALA LEU GLU ILE PRO ARG LEU
SEQRES  16 B  288  TYR ILE GLU ALA LEU ASP ASP VAL VAL LEU PRO ILE ALA
SEQRES  17 B  288  VAL GLN ARG GLN MSE GLN LYS GLU PHE PRO GLY PRO VAL
SEQRES  18 B  288  ALA VAL VAL SER LEU PRO ALA SER HIS ALA PRO TYR TYR
SEQRES  19 B  288  SER MSE PRO GLU ARG LEU ALA GLU ALA ILE ALA ASP PHE
SEQRES  20 B  288  ALA ASP ALA PRO ALA GLU TYR ARG GLN THR ALA THR LYS
SEQRES  21 B  288  ALA GLY PRO ASP ARG PRO ALA GLY ALA ASP GLY GLY ARG
SEQRES  22 B  288  ALA ASP ARG ALA ASP LEU PRO LEU GLU HIS HIS HIS HIS
SEQRES  23 B  288  HIS HIS
SEQRES   1 C  288  MSE THR VAL THR ASP ILE ILE LEU ILE HIS GLY ALA LEU
SEQRES   2 C  288  ASN ARG GLY ALA CYS TYR ASP ALA VAL VAL PRO LEU LEU
SEQRES   3 C  288  GLU ALA ARG GLY TYR ARG VAL HIS ALA PRO ASP LEU THR
SEQRES   4 C  288  GLY HIS THR PRO GLY ASP GLY GLY HIS LEU SER VAL VAL
SEQRES   5 C  288  ASP MSE GLU HIS TYR THR ARG PRO VAL ALA ASP ILE LEU
SEQRES   6 C  288  ALA ARG ALA GLU GLY GLN SER ILE LEU LEU GLY HIS SER
SEQRES   7 C  288  LEU GLY GLY ALA SER ILE SER TRP LEU ALA GLN HIS HIS
SEQRES   8 C  288  PRO ASP LYS VAL ALA GLY LEU ILE TYR LEU THR ALA VAL
SEQRES   9 C  288  LEU THR ALA PRO GLY VAL THR PRO GLU THR PHE VAL LEU
SEQRES  10 C  288  PRO GLY GLU PRO ASN ARG GLY THR PRO HIS ALA LEU ASP
SEQRES  11 C  288  LEU ILE GLN PRO VAL ASP GLU GLY ARG GLY LEU GLN ALA
SEQRES  12 C  288  ASP PHE SER ARG LEU GLU ARG LEU ARG GLU VAL PHE MSE
SEQRES  13 C  288  GLY ASP TYR PRO GLY GLU GLY MSE PRO PRO ALA GLU HIS
SEQRES  14 C  288  PHE ILE GLN THR GLN SER THR VAL PRO PHE GLY THR PRO
SEQRES  15 C  288  ASN PRO MSE GLU GLY ARG ALA LEU GLU ILE PRO ARG LEU
SEQRES  16 C  288  TYR ILE GLU ALA LEU ASP ASP VAL VAL LEU PRO ILE ALA
SEQRES  17 C  288  VAL GLN ARG GLN MSE GLN LYS GLU PHE PRO GLY PRO VAL
SEQRES  18 C  288  ALA VAL VAL SER LEU PRO ALA SER HIS ALA PRO TYR TYR
SEQRES  19 C  288  SER MSE PRO GLU ARG LEU ALA GLU ALA ILE ALA ASP PHE
SEQRES  20 C  288  ALA ASP ALA PRO ALA GLU TYR ARG GLN THR ALA THR LYS
SEQRES  21 C  288  ALA GLY PRO ASP ARG PRO ALA GLY ALA ASP GLY GLY ARG
SEQRES  22 C  288  ALA ASP ARG ALA ASP LEU PRO LEU GLU HIS HIS HIS HIS
SEQRES  23 C  288  HIS HIS
SEQRES   1 D  288  MSE THR VAL THR ASP ILE ILE LEU ILE HIS GLY ALA LEU
SEQRES   2 D  288  ASN ARG GLY ALA CYS TYR ASP ALA VAL VAL PRO LEU LEU
SEQRES   3 D  288  GLU ALA ARG GLY TYR ARG VAL HIS ALA PRO ASP LEU THR
SEQRES   4 D  288  GLY HIS THR PRO GLY ASP GLY GLY HIS LEU SER VAL VAL
SEQRES   5 D  288  ASP MSE GLU HIS TYR THR ARG PRO VAL ALA ASP ILE LEU
SEQRES   6 D  288  ALA ARG ALA GLU GLY GLN SER ILE LEU LEU GLY HIS SER
SEQRES   7 D  288  LEU GLY GLY ALA SER ILE SER TRP LEU ALA GLN HIS HIS
SEQRES   8 D  288  PRO ASP LYS VAL ALA GLY LEU ILE TYR LEU THR ALA VAL
SEQRES   9 D  288  LEU THR ALA PRO GLY VAL THR PRO GLU THR PHE VAL LEU
SEQRES  10 D  288  PRO GLY GLU PRO ASN ARG GLY THR PRO HIS ALA LEU ASP
SEQRES  11 D  288  LEU ILE GLN PRO VAL ASP GLU GLY ARG GLY LEU GLN ALA
SEQRES  12 D  288  ASP PHE SER ARG LEU GLU ARG LEU ARG GLU VAL PHE MSE
SEQRES  13 D  288  GLY ASP TYR PRO GLY GLU GLY MSE PRO PRO ALA GLU HIS
SEQRES  14 D  288  PHE ILE GLN THR GLN SER THR VAL PRO PHE GLY THR PRO
SEQRES  15 D  288  ASN PRO MSE GLU GLY ARG ALA LEU GLU ILE PRO ARG LEU
SEQRES  16 D  288  TYR ILE GLU ALA LEU ASP ASP VAL VAL LEU PRO ILE ALA
SEQRES  17 D  288  VAL GLN ARG GLN MSE GLN LYS GLU PHE PRO GLY PRO VAL
SEQRES  18 D  288  ALA VAL VAL SER LEU PRO ALA SER HIS ALA PRO TYR TYR
SEQRES  19 D  288  SER MSE PRO GLU ARG LEU ALA GLU ALA ILE ALA ASP PHE
SEQRES  20 D  288  ALA ASP ALA PRO ALA GLU TYR ARG GLN THR ALA THR LYS
SEQRES  21 D  288  ALA GLY PRO ASP ARG PRO ALA GLY ALA ASP GLY GLY ARG
SEQRES  22 D  288  ALA ASP ARG ALA ASP LEU PRO LEU GLU HIS HIS HIS HIS
SEQRES  23 D  288  HIS HIS
SEQRES   1 E  288  MSE THR VAL THR ASP ILE ILE LEU ILE HIS GLY ALA LEU
SEQRES   2 E  288  ASN ARG GLY ALA CYS TYR ASP ALA VAL VAL PRO LEU LEU
SEQRES   3 E  288  GLU ALA ARG GLY TYR ARG VAL HIS ALA PRO ASP LEU THR
SEQRES   4 E  288  GLY HIS THR PRO GLY ASP GLY GLY HIS LEU SER VAL VAL
SEQRES   5 E  288  ASP MSE GLU HIS TYR THR ARG PRO VAL ALA ASP ILE LEU
SEQRES   6 E  288  ALA ARG ALA GLU GLY GLN SER ILE LEU LEU GLY HIS SER
SEQRES   7 E  288  LEU GLY GLY ALA SER ILE SER TRP LEU ALA GLN HIS HIS
SEQRES   8 E  288  PRO ASP LYS VAL ALA GLY LEU ILE TYR LEU THR ALA VAL
SEQRES   9 E  288  LEU THR ALA PRO GLY VAL THR PRO GLU THR PHE VAL LEU
SEQRES  10 E  288  PRO GLY GLU PRO ASN ARG GLY THR PRO HIS ALA LEU ASP
SEQRES  11 E  288  LEU ILE GLN PRO VAL ASP GLU GLY ARG GLY LEU GLN ALA
SEQRES  12 E  288  ASP PHE SER ARG LEU GLU ARG LEU ARG GLU VAL PHE MSE
SEQRES  13 E  288  GLY ASP TYR PRO GLY GLU GLY MSE PRO PRO ALA GLU HIS
SEQRES  14 E  288  PHE ILE GLN THR GLN SER THR VAL PRO PHE GLY THR PRO
SEQRES  15 E  288  ASN PRO MSE GLU GLY ARG ALA LEU GLU ILE PRO ARG LEU
SEQRES  16 E  288  TYR ILE GLU ALA LEU ASP ASP VAL VAL LEU PRO ILE ALA
SEQRES  17 E  288  VAL GLN ARG GLN MSE GLN LYS GLU PHE PRO GLY PRO VAL
SEQRES  18 E  288  ALA VAL VAL SER LEU PRO ALA SER HIS ALA PRO TYR TYR
SEQRES  19 E  288  SER MSE PRO GLU ARG LEU ALA GLU ALA ILE ALA ASP PHE
SEQRES  20 E  288  ALA ASP ALA PRO ALA GLU TYR ARG GLN THR ALA THR LYS
SEQRES  21 E  288  ALA GLY PRO ASP ARG PRO ALA GLY ALA ASP GLY GLY ARG
SEQRES  22 E  288  ALA ASP ARG ALA ASP LEU PRO LEU GLU HIS HIS HIS HIS
SEQRES  23 E  288  HIS HIS
SEQRES   1 F  288  MSE THR VAL THR ASP ILE ILE LEU ILE HIS GLY ALA LEU
SEQRES   2 F  288  ASN ARG GLY ALA CYS TYR ASP ALA VAL VAL PRO LEU LEU
SEQRES   3 F  288  GLU ALA ARG GLY TYR ARG VAL HIS ALA PRO ASP LEU THR
SEQRES   4 F  288  GLY HIS THR PRO GLY ASP GLY GLY HIS LEU SER VAL VAL
SEQRES   5 F  288  ASP MSE GLU HIS TYR THR ARG PRO VAL ALA ASP ILE LEU
SEQRES   6 F  288  ALA ARG ALA GLU GLY GLN SER ILE LEU LEU GLY HIS SER
SEQRES   7 F  288  LEU GLY GLY ALA SER ILE SER TRP LEU ALA GLN HIS HIS
SEQRES   8 F  288  PRO ASP LYS VAL ALA GLY LEU ILE TYR LEU THR ALA VAL
SEQRES   9 F  288  LEU THR ALA PRO GLY VAL THR PRO GLU THR PHE VAL LEU
SEQRES  10 F  288  PRO GLY GLU PRO ASN ARG GLY THR PRO HIS ALA LEU ASP
SEQRES  11 F  288  LEU ILE GLN PRO VAL ASP GLU GLY ARG GLY LEU GLN ALA
SEQRES  12 F  288  ASP PHE SER ARG LEU GLU ARG LEU ARG GLU VAL PHE MSE
SEQRES  13 F  288  GLY ASP TYR PRO GLY GLU GLY MSE PRO PRO ALA GLU HIS
SEQRES  14 F  288  PHE ILE GLN THR GLN SER THR VAL PRO PHE GLY THR PRO
SEQRES  15 F  288  ASN PRO MSE GLU GLY ARG ALA LEU GLU ILE PRO ARG LEU
SEQRES  16 F  288  TYR ILE GLU ALA LEU ASP ASP VAL VAL LEU PRO ILE ALA
SEQRES  17 F  288  VAL GLN ARG GLN MSE GLN LYS GLU PHE PRO GLY PRO VAL
SEQRES  18 F  288  ALA VAL VAL SER LEU PRO ALA SER HIS ALA PRO TYR TYR
SEQRES  19 F  288  SER MSE PRO GLU ARG LEU ALA GLU ALA ILE ALA ASP PHE
SEQRES  20 F  288  ALA ASP ALA PRO ALA GLU TYR ARG GLN THR ALA THR LYS
SEQRES  21 F  288  ALA GLY PRO ASP ARG PRO ALA GLY ALA ASP GLY GLY ARG
SEQRES  22 F  288  ALA ASP ARG ALA ASP LEU PRO LEU GLU HIS HIS HIS HIS
SEQRES  23 F  288  HIS HIS
MODRES 5Y57 MSE A   54  MET  MODIFIED RESIDUE
MODRES 5Y57 MSE A  156  MET  MODIFIED RESIDUE
MODRES 5Y57 MSE A  164  MET  MODIFIED RESIDUE
MODRES 5Y57 MSE A  185  MET  MODIFIED RESIDUE
MODRES 5Y57 MSE A  213  MET  MODIFIED RESIDUE
MODRES 5Y57 MSE A  236  MET  MODIFIED RESIDUE
MODRES 5Y57 MSE B   54  MET  MODIFIED RESIDUE
MODRES 5Y57 MSE B  156  MET  MODIFIED RESIDUE
MODRES 5Y57 MSE B  164  MET  MODIFIED RESIDUE
MODRES 5Y57 MSE B  185  MET  MODIFIED RESIDUE
MODRES 5Y57 MSE B  213  MET  MODIFIED RESIDUE
MODRES 5Y57 MSE B  236  MET  MODIFIED RESIDUE
MODRES 5Y57 MSE C   54  MET  MODIFIED RESIDUE
MODRES 5Y57 MSE C  156  MET  MODIFIED RESIDUE
MODRES 5Y57 MSE C  164  MET  MODIFIED RESIDUE
MODRES 5Y57 MSE C  185  MET  MODIFIED RESIDUE
MODRES 5Y57 MSE C  213  MET  MODIFIED RESIDUE
MODRES 5Y57 MSE C  236  MET  MODIFIED RESIDUE
MODRES 5Y57 MSE D   54  MET  MODIFIED RESIDUE
MODRES 5Y57 MSE D  156  MET  MODIFIED RESIDUE
MODRES 5Y57 MSE D  164  MET  MODIFIED RESIDUE
MODRES 5Y57 MSE D  185  MET  MODIFIED RESIDUE
MODRES 5Y57 MSE D  213  MET  MODIFIED RESIDUE
MODRES 5Y57 MSE D  236  MET  MODIFIED RESIDUE
MODRES 5Y57 MSE E   54  MET  MODIFIED RESIDUE
MODRES 5Y57 MSE E  156  MET  MODIFIED RESIDUE
MODRES 5Y57 MSE E  164  MET  MODIFIED RESIDUE
MODRES 5Y57 MSE E  185  MET  MODIFIED RESIDUE
MODRES 5Y57 MSE E  213  MET  MODIFIED RESIDUE
MODRES 5Y57 MSE E  236  MET  MODIFIED RESIDUE
MODRES 5Y57 MSE F   54  MET  MODIFIED RESIDUE
MODRES 5Y57 MSE F  156  MET  MODIFIED RESIDUE
MODRES 5Y57 MSE F  164  MET  MODIFIED RESIDUE
MODRES 5Y57 MSE F  185  MET  MODIFIED RESIDUE
MODRES 5Y57 MSE F  213  MET  MODIFIED RESIDUE
MODRES 5Y57 MSE F  236  MET  MODIFIED RESIDUE
HET    MSE  A  54       8
HET    MSE  A 156       8
HET    MSE  A 164       8
HET    MSE  A 185       8
HET    MSE  A 213       8
HET    MSE  A 236       8
HET    MSE  B  54       8
HET    MSE  B 156       8
HET    MSE  B 164       8
HET    MSE  B 185       8
HET    MSE  B 213       8
HET    MSE  B 236       8
HET    MSE  C  54       8
HET    MSE  C 156       8
HET    MSE  C 164       8
HET    MSE  C 185       8
HET    MSE  C 213       8
HET    MSE  C 236       8
HET    MSE  D  54       8
HET    MSE  D 156       8
HET    MSE  D 164       8
HET    MSE  D 185       8
HET    MSE  D 213       8
HET    MSE  D 236       8
HET    MSE  E  54       8
HET    MSE  E 156       8
HET    MSE  E 164       8
HET    MSE  E 185       8
HET    MSE  E 213       8
HET    MSE  E 236       8
HET    MSE  F  54       8
HET    MSE  F 156       8
HET    MSE  F 164       8
HET    MSE  F 185       8
HET    MSE  F 213       8
HET    MSE  F 236       8
HET    PMS  A 301      10
HET    SO4  A 302       5
HET    PMS  B 301      10
HET    SO4  B 302       5
HET    PMS  C 301      10
HET    SO4  C 302       5
HET    PMS  D 301      10
HET    SO4  D 302       5
HET    PMS  E 301      10
HET    SO4  E 302       5
HET    PMS  F 301      10
HET    SO4  F 302       5
HETNAM     MSE SELENOMETHIONINE
HETNAM     PMS PHENYLMETHANESULFONIC ACID
HETNAM     SO4 SULFATE ION
FORMUL   1  MSE    36(C5 H11 N O2 SE)
FORMUL   7  PMS    6(C7 H8 O3 S)
FORMUL   8  SO4    6(O4 S 2-)
FORMUL  19  HOH   *430(H2 O)
HELIX    1 AA1 ARG A   15  ASP A   20  5                                   6
HELIX    2 AA2 VAL A   22  ARG A   29  1                                   8
HELIX    3 AA3 GLY A   47  VAL A   51  5                                   5
HELIX    4 AA4 ASP A   53  THR A   58  1                                   6
HELIX    5 AA5 THR A   58  ALA A   68  1                                  11
HELIX    6 AA6 LEU A   79  HIS A   91  1                                  13
HELIX    7 AA7 PRO A  112  LEU A  117  1                                   6
HELIX    8 AA8 THR A  125  LEU A  131  1                                   7
HELIX    9 AA9 ARG A  147  MSE A  156  1                                  10
HELIX   10 AB1 PRO A  166  PHE A  170  5                                   5
HELIX   11 AB2 THR A  176  THR A  181  1                                   6
HELIX   12 AB3 GLU A  186  ILE A  192  5                                   7
HELIX   13 AB4 PRO A  206  PHE A  217  1                                  12
HELIX   14 AB5 ALA A  231  MSE A  236  1                                   6
HELIX   15 AB6 MSE A  236  ASP A  249  1                                  14
HELIX   16 AB7 ARG B   15  ASP B   20  5                                   6
HELIX   17 AB8 VAL B   22  ALA B   28  1                                   7
HELIX   18 AB9 GLY B   47  VAL B   51  5                                   5
HELIX   19 AC1 ASP B   53  THR B   58  1                                   6
HELIX   20 AC2 THR B   58  ALA B   68  1                                  11
HELIX   21 AC3 LEU B   79  HIS B   91  1                                  13
HELIX   22 AC4 PRO B  112  LEU B  117  1                                   6
HELIX   23 AC5 THR B  125  LEU B  131  1                                   7
HELIX   24 AC6 ARG B  147  MSE B  156  1                                  10
HELIX   25 AC7 PRO B  166  PHE B  170  5                                   5
HELIX   26 AC8 THR B  176  THR B  181  1                                   6
HELIX   27 AC9 GLU B  186  ILE B  192  5                                   7
HELIX   28 AD1 PRO B  206  PHE B  217  1                                  12
HELIX   29 AD2 ALA B  231  MSE B  236  1                                   6
HELIX   30 AD3 MSE B  236  ALA B  250  1                                  15
HELIX   31 AD4 ARG C   15  ASP C   20  5                                   6
HELIX   32 AD5 VAL C   22  ALA C   28  1                                   7
HELIX   33 AD6 GLY C   47  VAL C   51  5                                   5
HELIX   34 AD7 ASP C   53  THR C   58  1                                   6
HELIX   35 AD8 THR C   58  ALA C   68  1                                  11
HELIX   36 AD9 LEU C   79  HIS C   91  1                                  13
HELIX   37 AE1 PRO C  112  LEU C  117  1                                   6
HELIX   38 AE2 THR C  125  LEU C  131  1                                   7
HELIX   39 AE3 ARG C  147  MSE C  156  1                                  10
HELIX   40 AE4 PRO C  166  PHE C  170  5                                   5
HELIX   41 AE5 THR C  176  THR C  181  1                                   6
HELIX   42 AE6 GLU C  186  ILE C  192  5                                   7
HELIX   43 AE7 PRO C  206  PHE C  217  1                                  12
HELIX   44 AE8 ALA C  231  MSE C  236  1                                   6
HELIX   45 AE9 MSE C  236  ALA C  250  1                                  15
HELIX   46 AF1 PRO C  251  TYR C  254  5                                   4
HELIX   47 AF2 ARG D   15  ASP D   20  5                                   6
HELIX   48 AF3 ALA D   21  ARG D   29  1                                   9
HELIX   49 AF4 GLY D   47  VAL D   51  5                                   5
HELIX   50 AF5 ASP D   53  THR D   58  1                                   6
HELIX   51 AF6 THR D   58  ALA D   68  1                                  11
HELIX   52 AF7 LEU D   79  HIS D   91  1                                  13
HELIX   53 AF8 PRO D  112  LEU D  117  1                                   6
HELIX   54 AF9 THR D  125  LEU D  131  1                                   7
HELIX   55 AG1 ARG D  147  MSE D  156  1                                  10
HELIX   56 AG2 PRO D  166  PHE D  170  5                                   5
HELIX   57 AG3 VAL D  177  GLY D  180  5                                   4
HELIX   58 AG4 GLU D  186  ILE D  192  5                                   7
HELIX   59 AG5 PRO D  206  PHE D  217  1                                  12
HELIX   60 AG6 ALA D  231  MSE D  236  1                                   6
HELIX   61 AG7 MSE D  236  ALA D  250  1                                  15
HELIX   62 AG8 ARG E   15  ASP E   20  5                                   6
HELIX   63 AG9 VAL E   22  ALA E   28  1                                   7
HELIX   64 AH1 ASP E   53  THR E   58  1                                   6
HELIX   65 AH2 THR E   58  ALA E   68  1                                  11
HELIX   66 AH3 LEU E   79  HIS E   91  1                                  13
HELIX   67 AH4 PRO E  112  LEU E  117  1                                   6
HELIX   68 AH5 THR E  125  LEU E  131  1                                   7
HELIX   69 AH6 ARG E  147  MSE E  156  1                                  10
HELIX   70 AH7 PRO E  166  PHE E  170  5                                   5
HELIX   71 AH8 THR E  176  THR E  181  1                                   6
HELIX   72 AH9 GLY E  187  ILE E  192  1                                   6
HELIX   73 AI1 PRO E  206  PHE E  217  1                                  12
HELIX   74 AI2 ALA E  231  MSE E  236  1                                   6
HELIX   75 AI3 MSE E  236  ALA E  250  1                                  15
HELIX   76 AI4 PRO E  251  TYR E  254  5                                   4
HELIX   77 AI5 ARG F   15  ASP F   20  5                                   6
HELIX   78 AI6 VAL F   22  ALA F   28  1                                   7
HELIX   79 AI7 GLY F   46  VAL F   51  5                                   6
HELIX   80 AI8 ASP F   53  THR F   58  1                                   6
HELIX   81 AI9 THR F   58  ALA F   68  1                                  11
HELIX   82 AJ1 LEU F   79  HIS F   91  1                                  13
HELIX   83 AJ2 PRO F  112  LEU F  117  1                                   6
HELIX   84 AJ3 THR F  125  ILE F  132  1                                   8
HELIX   85 AJ4 ASP F  144  SER F  146  5                                   3
HELIX   86 AJ5 ARG F  147  MSE F  156  1                                  10
HELIX   87 AJ6 PRO F  166  PHE F  170  5                                   5
HELIX   88 AJ7 THR F  176  THR F  181  1                                   6
HELIX   89 AJ8 GLU F  186  ILE F  192  5                                   7
HELIX   90 AJ9 PRO F  206  GLU F  216  1                                  11
HELIX   91 AK1 ALA F  231  MSE F  236  1                                   6
HELIX   92 AK2 MSE F  236  ALA F  250  1                                  15
SHEET    1 AA1 6 ARG A  32  HIS A  34  0
SHEET    2 AA1 6 VAL A   3  ILE A   9  1  N  LEU A   8   O  HIS A  34
SHEET    3 AA1 6 GLN A  71  HIS A  77  1  O  ILE A  73   N  ILE A   7
SHEET    4 AA1 6 VAL A  95  LEU A 101  1  O  ILE A  99   N  LEU A  74
SHEET    5 AA1 6 ARG A 194  ALA A 199  1  O  LEU A 195   N  TYR A 100
SHEET    6 AA1 6 ALA A 222  LEU A 226  1  O  ALA A 222   N  TYR A 196
SHEET    1 AA2 3 ILE A 132  VAL A 135  0
SHEET    2 AA2 3 GLY A 140  ALA A 143 -1  O  GLN A 142   N  GLN A 133
SHEET    3 AA2 3 GLN A 174  SER A 175 -1  O  GLN A 174   N  LEU A 141
SHEET    1 AA3 6 ARG B  32  HIS B  34  0
SHEET    2 AA3 6 VAL B   3  ILE B   9  1  N  LEU B   8   O  HIS B  34
SHEET    3 AA3 6 GLN B  71  HIS B  77  1  O  LEU B  75   N  ILE B   9
SHEET    4 AA3 6 VAL B  95  LEU B 101  1  O  ILE B  99   N  LEU B  74
SHEET    5 AA3 6 ARG B 194  ALA B 199  1  O  LEU B 195   N  TYR B 100
SHEET    6 AA3 6 ALA B 222  LEU B 226  1  O  ALA B 222   N  TYR B 196
SHEET    1 AA4 3 ILE B 132  VAL B 135  0
SHEET    2 AA4 3 GLY B 140  ALA B 143 -1  O  GLN B 142   N  GLN B 133
SHEET    3 AA4 3 GLN B 174  SER B 175 -1  O  GLN B 174   N  LEU B 141
SHEET    1 AA5 6 ARG C  32  HIS C  34  0
SHEET    2 AA5 6 VAL C   3  ILE C   9  1  N  LEU C   8   O  HIS C  34
SHEET    3 AA5 6 GLN C  71  HIS C  77  1  O  LEU C  75   N  ILE C   7
SHEET    4 AA5 6 VAL C  95  LEU C 101  1  O  ILE C  99   N  LEU C  74
SHEET    5 AA5 6 ARG C 194  ALA C 199  1  O  LEU C 195   N  TYR C 100
SHEET    6 AA5 6 ALA C 222  LEU C 226  1  O  LEU C 226   N  GLU C 198
SHEET    1 AA6 3 ILE C 132  VAL C 135  0
SHEET    2 AA6 3 GLY C 140  ALA C 143 -1  O  GLN C 142   N  GLN C 133
SHEET    3 AA6 3 GLN C 174  SER C 175 -1  O  GLN C 174   N  LEU C 141
SHEET    1 AA7 6 ARG D  32  HIS D  34  0
SHEET    2 AA7 6 VAL D   3  ILE D   9  1  N  LEU D   8   O  HIS D  34
SHEET    3 AA7 6 GLN D  71  HIS D  77  1  O  LEU D  75   N  ILE D   9
SHEET    4 AA7 6 VAL D  95  LEU D 101  1  O  ILE D  99   N  LEU D  74
SHEET    5 AA7 6 ARG D 194  ALA D 199  1  O  LEU D 195   N  LEU D  98
SHEET    6 AA7 6 ALA D 222  LEU D 226  1  O  ALA D 222   N  TYR D 196
SHEET    1 AA8 3 ILE D 132  VAL D 135  0
SHEET    2 AA8 3 GLY D 140  ALA D 143 -1  O  GLN D 142   N  GLN D 133
SHEET    3 AA8 3 GLN D 174  SER D 175 -1  O  GLN D 174   N  LEU D 141
SHEET    1 AA9 6 ARG E  32  HIS E  34  0
SHEET    2 AA9 6 VAL E   3  ILE E   9  1  N  LEU E   8   O  HIS E  34
SHEET    3 AA9 6 GLN E  71  SER E  78  1  O  LEU E  75   N  ILE E   9
SHEET    4 AA9 6 VAL E  95  ALA E 103  1  O  LEU E 101   N  GLY E  76
SHEET    5 AA9 6 ARG E 194  ALA E 199  1  O  ILE E 197   N  TYR E 100
SHEET    6 AA9 6 ALA E 222  LEU E 226  1  O  VAL E 224   N  GLU E 198
SHEET    1 AB1 3 ILE E 132  VAL E 135  0
SHEET    2 AB1 3 GLY E 140  ALA E 143 -1  O  GLN E 142   N  GLN E 133
SHEET    3 AB1 3 THR E 173  SER E 175 -1  O  GLN E 174   N  LEU E 141
SHEET    1 AB2 6 ARG F  32  HIS F  34  0
SHEET    2 AB2 6 ASP F   5  ILE F   9  1  N  ILE F   6   O  ARG F  32
SHEET    3 AB2 6 ILE F  73  HIS F  77  1  O  ILE F  73   N  ILE F   7
SHEET    4 AB2 6 GLY F  97  LEU F 101  1  O  ILE F  99   N  LEU F  74
SHEET    5 AB2 6 ARG F 194  ALA F 199  1  O  LEU F 195   N  TYR F 100
SHEET    6 AB2 6 ALA F 222  LEU F 226  1  O  ALA F 222   N  TYR F 196
LINK         C   ASP A  53                 N   MSE A  54     1555   1555  1.33
LINK         C   MSE A  54                 N   GLU A  55     1555   1555  1.34
LINK         OG ASER A  78                 S   PMS A 301     1555   1555  1.57
LINK         C   PHE A 155                 N   MSE A 156     1555   1555  1.34
LINK         C   MSE A 156                 N   GLY A 157     1555   1555  1.33
LINK         C   MSE A 164                 N   PRO A 165     1555   1555  1.32
LINK         C   PRO A 184                 N   MSE A 185     1555   1555  1.32
LINK         C   MSE A 185                 N   GLU A 186     1555   1555  1.33
LINK         C   GLN A 212                 N   MSE A 213     1555   1555  1.33
LINK         C   MSE A 213                 N   GLN A 214     1555   1555  1.33
LINK         C   SER A 235                 N   MSE A 236     1555   1555  1.34
LINK         C   MSE A 236                 N   PRO A 237     1555   1555  1.33
LINK         C   ASP B  53                 N   MSE B  54     1555   1555  1.33
LINK         C   MSE B  54                 N   GLU B  55     1555   1555  1.35
LINK         OG ASER B  78                 S   PMS B 301     1555   1555  1.57
LINK         C   PHE B 155                 N   MSE B 156     1555   1555  1.33
LINK         C   MSE B 156                 N   GLY B 157     1555   1555  1.33
LINK         C   GLY B 163                 N   MSE B 164     1555   1555  1.32
LINK         C   MSE B 164                 N   PRO B 165     1555   1555  1.39
LINK         C   PRO B 184                 N   MSE B 185     1555   1555  1.33
LINK         C   MSE B 185                 N   GLU B 186     1555   1555  1.33
LINK         C   GLN B 212                 N   MSE B 213     1555   1555  1.33
LINK         C   MSE B 213                 N   GLN B 214     1555   1555  1.34
LINK         C   SER B 235                 N   MSE B 236     1555   1555  1.33
LINK         C   MSE B 236                 N   PRO B 237     1555   1555  1.34
LINK         C   ASP C  53                 N   MSE C  54     1555   1555  1.33
LINK         C   MSE C  54                 N   GLU C  55     1555   1555  1.34
LINK         OG ASER C  78                 S   PMS C 301     1555   1555  1.56
LINK         OG BSER C  78                 S   PMS C 301     1555   1555  1.47
LINK         C   PHE C 155                 N   MSE C 156     1555   1555  1.33
LINK         C   MSE C 156                 N   GLY C 157     1555   1555  1.33
LINK         C   GLY C 163                 N   MSE C 164     1555   1555  1.33
LINK         C   MSE C 164                 N   PRO C 165     1555   1555  1.34
LINK         C   PRO C 184                 N   MSE C 185     1555   1555  1.33
LINK         C   MSE C 185                 N   GLU C 186     1555   1555  1.34
LINK         C   GLN C 212                 N   MSE C 213     1555   1555  1.33
LINK         C   MSE C 213                 N   GLN C 214     1555   1555  1.34
LINK         C   SER C 235                 N   MSE C 236     1555   1555  1.33
LINK         C   MSE C 236                 N   PRO C 237     1555   1555  1.33
LINK         C   ASP D  53                 N   MSE D  54     1555   1555  1.32
LINK         C   MSE D  54                 N   GLU D  55     1555   1555  1.34
LINK         OG ASER D  78                 S   PMS D 301     1555   1555  1.54
LINK         OG BSER D  78                 S   PMS D 301     1555   1555  1.63
LINK         C   PHE D 155                 N   MSE D 156     1555   1555  1.33
LINK         C   MSE D 156                 N   GLY D 157     1555   1555  1.33
LINK         C   GLY D 163                 N   MSE D 164     1555   1555  1.31
LINK         C   MSE D 164                 N   PRO D 165     1555   1555  1.32
LINK         C   PRO D 184                 N   MSE D 185     1555   1555  1.33
LINK         C   MSE D 185                 N   GLU D 186     1555   1555  1.33
LINK         C   GLN D 212                 N   MSE D 213     1555   1555  1.33
LINK         C   MSE D 213                 N   GLN D 214     1555   1555  1.34
LINK         C   SER D 235                 N   MSE D 236     1555   1555  1.33
LINK         C   MSE D 236                 N   PRO D 237     1555   1555  1.34
LINK         C   ASP E  53                 N   MSE E  54     1555   1555  1.34
LINK         C   MSE E  54                 N   GLU E  55     1555   1555  1.33
LINK         OG ASER E  78                 S   PMS E 301     1555   1555  1.56
LINK         C   PHE E 155                 N   MSE E 156     1555   1555  1.33
LINK         C   MSE E 156                 N   GLY E 157     1555   1555  1.33
LINK         C   MSE E 164                 N   PRO E 165     1555   1555  1.33
LINK         C   PRO E 184                 N   MSE E 185     1555   1555  1.32
LINK         C   MSE E 185                 N   GLU E 186     1555   1555  1.34
LINK         C   GLN E 212                 N   MSE E 213     1555   1555  1.31
LINK         C   MSE E 213                 N   GLN E 214     1555   1555  1.31
LINK         C   SER E 235                 N   MSE E 236     1555   1555  1.32
LINK         C   MSE E 236                 N   PRO E 237     1555   1555  1.34
LINK         C   ASP F  53                 N   MSE F  54     1555   1555  1.33
LINK         C   MSE F  54                 N   GLU F  55     1555   1555  1.34
LINK         OG ASER F  78                 S   PMS F 301     1555   1555  1.51
LINK         C   PHE F 155                 N   MSE F 156     1555   1555  1.32
LINK         C   MSE F 156                 N   GLY F 157     1555   1555  1.33
LINK         C   GLY F 163                 N   MSE F 164     1555   1555  1.33
LINK         C   MSE F 164                 N   PRO F 165     1555   1555  1.33
LINK         C   PRO F 184                 N   MSE F 185     1555   1555  1.33
LINK         C   MSE F 185                 N   GLU F 186     1555   1555  1.33
LINK         C   GLN F 212                 N   MSE F 213     1555   1555  1.33
LINK         C   MSE F 213                 N   GLN F 214     1555   1555  1.34
LINK         C   SER F 235                 N   MSE F 236     1555   1555  1.32
LINK         C   MSE F 236                 N   PRO F 237     1555   1555  1.34
CISPEP   1 GLU A  120    PRO A  121          0        -9.92
CISPEP   2 GLU B  120    PRO B  121          0         0.42
CISPEP   3 GLU C  120    PRO C  121          0        -3.59
CISPEP   4 GLU D  120    PRO D  121          0        -5.03
CISPEP   5 GLU E  120    PRO E  121          0        -6.44
CISPEP   6 GLU F  120    PRO F  121          0         8.29
SITE     1 AC1  6 ALA A  12  SER A  78  LEU A  79  ALA A 128
SITE     2 AC1  6 PHE A 179  HIS A 230
SITE     1 AC2  5 MSE A 236  PRO A 237  GLU A 238  ARG A 239
SITE     2 AC2  5 HOH A 421
SITE     1 AC3  5 SER B 235  MSE B 236  PRO B 237  GLU B 238
SITE     2 AC3  5 ARG B 239
SITE     1 AC4  6 SER C 235  MSE C 236  PRO C 237  GLU C 238
SITE     2 AC4  6 ARG C 239  HOH C 421
SITE     1 AC5  5 SER D 235  MSE D 236  PRO D 237  GLU D 238
SITE     2 AC5  5 ARG D 239
SITE     1 AC6  5 SER E 235  MSE E 236  PRO E 237  GLU E 238
SITE     2 AC6  5 ARG E 239
SITE     1 AC7  4 MSE F 236  PRO F 237  GLU F 238  ARG F 239
SITE     1 AC8 12 ALA B  12  HIS B  77  LEU B  79  GLY B  80
SITE     2 AC8 12 GLY B  81  LEU B 101  THR B 102  ALA B 103
SITE     3 AC8 12 VAL B 104  ALA B 128  HIS B 230  HOH B 413
SITE     1 AC9 12 ALA C  12  HIS C  77  LEU C  79  GLY C  80
SITE     2 AC9 12 GLY C  81  LEU C 101  THR C 102  ALA C 103
SITE     3 AC9 12 VAL C 104  ALA C 128  VAL C 204  HIS C 230
SITE     1 AD1 12 ALA C  12  HIS C  77  LEU C  79  GLY C  80
SITE     2 AD1 12 GLY C  81  LEU C 101  THR C 102  ALA C 103
SITE     3 AD1 12 VAL C 104  ALA C 128  VAL C 204  HIS C 230
SITE     1 AD2 11 ALA D  12  HIS D  77  LEU D  79  GLY D  80
SITE     2 AD2 11 GLY D  81  LEU D 101  THR D 102  ALA D 103
SITE     3 AD2 11 VAL D 104  PHE D 179  HIS D 230
SITE     1 AD3 11 ALA D  12  HIS D  77  LEU D  79  GLY D  80
SITE     2 AD3 11 GLY D  81  LEU D 101  THR D 102  ALA D 103
SITE     3 AD3 11 VAL D 104  PHE D 179  HIS D 230
SITE     1 AD4 14 ALA E  12  HIS E  77  LEU E  79  GLY E  80
SITE     2 AD4 14 GLY E  81  LEU E 101  THR E 102  ALA E 103
SITE     3 AD4 14 VAL E 104  ALA E 128  ILE E 132  PHE E 179
SITE     4 AD4 14 VAL E 204  HIS E 230
SITE     1 AD5 12 ALA F  12  HIS F  77  LEU F  79  GLY F  80
SITE     2 AD5 12 GLY F  81  LEU F 101  THR F 102  ALA F 103
SITE     3 AD5 12 VAL F 104  VAL F 116  THR F 125  ALA F 128
CRYST1  168.453  168.453  123.593  90.00  90.00  90.00 P 42 21 2    48
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.005936  0.000000  0.000000        0.00000
SCALE2      0.000000  0.005936  0.000000        0.00000
SCALE3      0.000000  0.000000  0.008091        0.00000
TER    1917      TYR A 254
TER    3838      TYR B 254
TER    5762      TYR C 254
TER    7683      TYR D 254
TER    9583      TYR E 254
TER   11457      TYR F 254
MASTER      698    0   48   92   51    0   35    611935    6  458  138
END