longtext: 6agq-pdb

content
HEADER    HYDROLASE                               13-AUG-18   6AGQ
TITLE     ACETYL XYLAN ESTERASE FROM PAENIBACILLUS SP. R4
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: ACETYL XYLAN ESTERASE;
COMPND   3 CHAIN: A, B, C, D, E, F;
COMPND   4 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: PAENIBACILLUS SP. R4;
SOURCE   3 ORGANISM_TAXID: 1079050;
SOURCE   4 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   5 EXPRESSION_SYSTEM_TAXID: 562
KEYWDS    PAENIBACILLUS SP., ACETYL ESTERASE, ACETYL XYLAN ESTERASES, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    S.PARK,C.W.LEE,J.H.LEE
REVDAT   1   10-OCT-18 6AGQ    0
JRNL        AUTH   S.PARK,C.W.LEE,J.H.LEE
JRNL        TITL   ACETYL XYLAN ESTERASE FROM PAENIBACILLUS SP. R4
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   2
REMARK   2 RESOLUTION.    2.10 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.8.0189
REMARK   3   AUTHORS     : MURSHUDOV,SKUBAK,LEBEDEV,PANNU,STEINER,
REMARK   3               : NICHOLLS,WINN,LONG,VAGIN
REMARK   3
REMARK   3    REFINEMENT TARGET : NULL
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.10
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 49.39
REMARK   3   DATA CUTOFF            (SIGMA(F)) : NULL
REMARK   3   COMPLETENESS FOR RANGE        (%) : 96.1
REMARK   3   NUMBER OF REFLECTIONS             : 115533
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.201
REMARK   3   R VALUE            (WORKING SET) : 0.198
REMARK   3   FREE R VALUE                     : 0.254
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.100
REMARK   3   FREE R VALUE TEST SET COUNT      : 6247
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 2.10
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 2.16
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 8000
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 90.55
REMARK   3   BIN R VALUE           (WORKING SET) : 0.3660
REMARK   3   BIN FREE R VALUE SET COUNT          : 439
REMARK   3   BIN FREE R VALUE                    : 0.3860
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 15060
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 6
REMARK   3   SOLVENT ATOMS            : 767
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 35.78
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : 0.00000
REMARK   3    B22 (A**2) : -0.01000
REMARK   3    B33 (A**2) : 0.01000
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : 0.00000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): 0.237
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.204
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.161
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 6.481
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.944
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.912
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A): 15510 ; 0.017 ; 0.019
REMARK   3   BOND LENGTHS OTHERS               (A): 13836 ; 0.002 ; 0.020
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES): 21096 ; 1.806 ; 1.956
REMARK   3   BOND ANGLES OTHERS          (DEGREES): 32106 ; 1.090 ; 3.000
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):  1890 ; 7.058 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   750 ;34.505 ;23.360
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):  2400 ;15.252 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):   102 ;15.962 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):  2172 ; 0.117 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A): 17502 ; 0.009 ; 0.021
REMARK   3   GENERAL PLANES OTHERS             (A):  3336 ; 0.002 ; 0.020
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  7578 ; 2.897 ; 3.365
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  7577 ; 2.896 ; 3.364
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  9462 ; 3.969 ; 5.036
REMARK   3   MAIN-CHAIN ANGLE OTHER ATOMS   (A**2):  9463 ; 3.969 ; 5.037
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  7932 ; 3.673 ; 3.804
REMARK   3   SIDE-CHAIN BOND OTHER ATOMS    (A**2):  7933 ; 3.673 ; 3.804
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN ANGLE OTHER ATOMS   (A**2): 11635 ; 5.587 ; 5.541
REMARK   3   LONG RANGE B REFINED ATOMS     (A**2): 17548 ; 7.128 ;39.737
REMARK   3   LONG RANGE B OTHER ATOMS       (A**2): 17416 ; 7.094 ;39.592
REMARK   3
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : NULL
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.20
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE RIDING
REMARK   3  POSITIONS
REMARK   4
REMARK   4 6AGQ COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 23-AUG-18.
REMARK 100 THE DEPOSITION ID IS D_1300008721.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 26-JUL-17
REMARK 200  TEMPERATURE           (KELVIN) : 200
REMARK 200  PH                             : 5.0
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : PAL/PLS
REMARK 200  BEAMLINE                       : 5C (4A)
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9796
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 315R
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : NULL
REMARK 200  DATA SCALING SOFTWARE          : HKL-2000
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 121844
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.100
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 96.8
REMARK 200  DATA REDUNDANCY                : 3.700
REMARK 200  R MERGE                    (I) : NULL
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 27.2000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.10
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.14
REMARK 200  COMPLETENESS FOR SHELL     (%) : NULL
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL
REMARK 200  R MERGE FOR SHELL          (I) : NULL
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: NULL
REMARK 200 SOFTWARE USED: NULL
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 52.69
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.60
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 1.8 M SODIUM PHOSPHATE MONOBASIC
REMARK 280  MONOHYDRATE, POTASSIUM PHOSPHATE DIBASIC PH 5.0, VAPOR DIFFUSION,
REMARK 280  SITTING DROP, TEMPERATURE 293K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: C 1 2 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,Y,-Z
REMARK 290       3555   X+1/2,Y+1/2,Z
REMARK 290       4555   -X+1/2,Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   3  1.000000  0.000000  0.000000       76.89850
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       70.82950
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   4 -1.000000  0.000000  0.000000       76.89850
REMARK 290   SMTRY2   4  0.000000  1.000000  0.000000       70.82950
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: HEXAMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: HEXAMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 15920 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 65310 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -278.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A     1
REMARK 465     PRO A     2
REMARK 465     ASN A     3
REMARK 465     VAL A     4
REMARK 465     ASP A     5
REMARK 465     MET B     1
REMARK 465     PRO B     2
REMARK 465     ASN B     3
REMARK 465     VAL B     4
REMARK 465     ASP B     5
REMARK 465     MET C     1
REMARK 465     PRO C     2
REMARK 465     ASN C     3
REMARK 465     VAL C     4
REMARK 465     ASP C     5
REMARK 465     MET D     1
REMARK 465     PRO D     2
REMARK 465     ASN D     3
REMARK 465     VAL D     4
REMARK 465     ASP D     5
REMARK 465     MET E     1
REMARK 465     PRO E     2
REMARK 465     ASN E     3
REMARK 465     VAL E     4
REMARK 465     ASP E     5
REMARK 465     MET F     1
REMARK 465     PRO F     2
REMARK 465     ASN F     3
REMARK 465     VAL F     4
REMARK 465     ASP F     5
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   O    HOH C   514     O    HOH C   623              2.08
REMARK 500   O    HOH F   541     O    HOH F   578              2.19
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    ARG B 235   NE  -  CZ  -  NH2 ANGL. DEV. =   3.2 DEGREES
REMARK 500    ARG D 248   NE  -  CZ  -  NH1 ANGL. DEV. =   3.1 DEGREES
REMARK 500    ASP E 160   CB  -  CG  -  OD1 ANGL. DEV. =   8.2 DEGREES
REMARK 500    ASP E 160   CB  -  CG  -  OD2 ANGL. DEV. =  -6.8 DEGREES
REMARK 500    ASP F 160   CB  -  CG  -  OD1 ANGL. DEV. =   5.6 DEGREES
REMARK 500    ARG F 171   NE  -  CZ  -  NH1 ANGL. DEV. =   3.7 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    SER A  96       -5.50     88.10
REMARK 500    GLN A 123     -148.06    -89.93
REMARK 500    SER A 185     -119.16     63.05
REMARK 500    PHE A 208       67.64     28.90
REMARK 500    ASP A 237       68.29   -163.72
REMARK 500    LYS B  53      -20.41     71.45
REMARK 500    SER B  96       -5.07     87.51
REMARK 500    GLN B 123     -157.74    -86.15
REMARK 500    SER B 185     -117.26     65.55
REMARK 500    PHE B 208       63.68     27.85
REMARK 500    ASP B 237       66.28   -163.90
REMARK 500    ASP C  49       35.77     72.27
REMARK 500    LYS C  53      -24.72     81.51
REMARK 500    SER C  96       -5.06     94.19
REMARK 500    ARG C  99       -9.61    -51.74
REMARK 500    SER C 185     -122.75     67.60
REMARK 500    PHE C 208       68.22     13.79
REMARK 500    ASP C 237       65.97   -163.69
REMARK 500    SER D  96       -2.90     87.30
REMARK 500    SER D 185     -115.92     55.30
REMARK 500    PHE D 208       66.26     16.05
REMARK 500    LEU D 211       43.02     70.00
REMARK 500    ASP D 237       68.39   -153.45
REMARK 500    LYS E  53      -27.70     77.82
REMARK 500    SER E  96       -6.62     88.12
REMARK 500    ARG E  99       -5.78    -58.66
REMARK 500    GLN E 123     -153.70    -91.47
REMARK 500    SER E 185     -117.16     61.02
REMARK 500    PHE E 208       63.91     28.09
REMARK 500    LEU E 211       31.02     72.02
REMARK 500    ASP E 237       63.23   -163.09
REMARK 500    ASN F  45      111.10   -163.59
REMARK 500    ASP F  49       62.94     33.49
REMARK 500    SER F  96       -0.88     83.39
REMARK 500    ARG F  99       -9.55    -59.03
REMARK 500    GLN F 123     -154.46    -98.03
REMARK 500    SER F 185     -119.75     69.34
REMARK 500    PHE F 208       68.28     22.84
REMARK 500    HIS F 213       75.80     44.43
REMARK 500    ASP F 237       73.08   -161.77
REMARK 500
REMARK 500 REMARK: NULL
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN A 401
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN B 401
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN C 401
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN D 401
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN F 401
DBREF  6AGQ A    1   321  PDB    6AGQ     6AGQ             1    321
DBREF  6AGQ B    1   321  PDB    6AGQ     6AGQ             1    321
DBREF  6AGQ C    1   321  PDB    6AGQ     6AGQ             1    321
DBREF  6AGQ D    1   321  PDB    6AGQ     6AGQ             1    321
DBREF  6AGQ E    1   321  PDB    6AGQ     6AGQ             1    321
DBREF  6AGQ F    1   321  PDB    6AGQ     6AGQ             1    321
SEQRES   1 A  321  MET PRO ASN VAL ASP MET PRO LEU SER GLN LEU GLN ASP
SEQRES   2 A  321  TYR LYS PRO GLU LEU THR ASN GLU THR ASP PHE ASP LEU
SEQRES   3 A  321  PHE TRP ASP ASN ALA LYS ALA LEU SER ASN GLN LYS PRO
SEQRES   4 A  321  LEU HIS ALA GLN VAL ASN LEU VAL GLN ASP TYR PRO LEU
SEQRES   5 A  321  LYS SER ILE SER ILE TYR ASP VAL VAL TYR ASP GLY ALA
SEQRES   6 A  321  ASP GLY THR PRO ILE HIS GLY TRP TYR VAL THR PRO LYS
SEQRES   7 A  321  GLY GLU HIS GLN PRO GLY SER LEU PRO VAL LEU VAL LYS
SEQRES   8 A  321  TYR HIS GLY TYR SER GLY ASN ARG GLY TYR PRO ASN GLU
SEQRES   9 A  321  LEU LEU GLN TRP ALA SER MET GLY MET ALA ALA LEU ALA
SEQRES  10 A  321  ILE ASP VAL ARG GLY GLN GLY GLY VAL THR PRO ASP ARG
SEQRES  11 A  321  ALA GLU TYR PRO GLN GLY GLY ILE PRO GLY TRP MET THR
SEQRES  12 A  321  LEU GLY ILE LEU ASP PRO ALA SER TYR TYR TYR LYS GLN
SEQRES  13 A  321  VAL TYR LEU ASP CYS ILE ARG ALA LEU ASP PHE VAL CYS
SEQRES  14 A  321  SER ARG GLU GLU VAL ASP ALA SER ARG ILE ALA VAL TYR
SEQRES  15 A  321  GLY GLY SER GLN GLY GLY GLY LEU ALA LEU ALA ALA ALA
SEQRES  16 A  321  GLY LEU ASP SER ARG PRO LYS LEU ALA LEU PRO VAL PHE
SEQRES  17 A  321  PRO PHE LEU CYS HIS PHE ARG ARG SER VAL GLU ILE HIS
SEQRES  18 A  321  ALA SER GLY PRO TYR VAL GLU ILE LYS ASN TRP PHE ARG
SEQRES  19 A  321  ARG TYR ASP PRO GLU HIS ARG GLN GLU GLU GLN VAL TYR
SEQRES  20 A  321  ARG THR LEU SER TYR PHE ASP GLY MET ASN MET ALA SER
SEQRES  21 A  321  ARG ILE LYS ALA ARG THR LEU MET ALA ILE THR LEU GLN
SEQRES  22 A  321  ASP ILE THR CYS PRO PRO SER THR CYS PHE ALA ALA TYR
SEQRES  23 A  321  ASN HIS LEU ALA GLY PRO LYS GLU VAL ARG LEU TYR HIS
SEQRES  24 A  321  ASP TYR GLY HIS GLU GLY LEU PRO PHE HIS GLU GLU ALA
SEQRES  25 A  321  MET MET ARG PHE ILE GLU ALA TYR LEU
SEQRES   1 B  321  MET PRO ASN VAL ASP MET PRO LEU SER GLN LEU GLN ASP
SEQRES   2 B  321  TYR LYS PRO GLU LEU THR ASN GLU THR ASP PHE ASP LEU
SEQRES   3 B  321  PHE TRP ASP ASN ALA LYS ALA LEU SER ASN GLN LYS PRO
SEQRES   4 B  321  LEU HIS ALA GLN VAL ASN LEU VAL GLN ASP TYR PRO LEU
SEQRES   5 B  321  LYS SER ILE SER ILE TYR ASP VAL VAL TYR ASP GLY ALA
SEQRES   6 B  321  ASP GLY THR PRO ILE HIS GLY TRP TYR VAL THR PRO LYS
SEQRES   7 B  321  GLY GLU HIS GLN PRO GLY SER LEU PRO VAL LEU VAL LYS
SEQRES   8 B  321  TYR HIS GLY TYR SER GLY ASN ARG GLY TYR PRO ASN GLU
SEQRES   9 B  321  LEU LEU GLN TRP ALA SER MET GLY MET ALA ALA LEU ALA
SEQRES  10 B  321  ILE ASP VAL ARG GLY GLN GLY GLY VAL THR PRO ASP ARG
SEQRES  11 B  321  ALA GLU TYR PRO GLN GLY GLY ILE PRO GLY TRP MET THR
SEQRES  12 B  321  LEU GLY ILE LEU ASP PRO ALA SER TYR TYR TYR LYS GLN
SEQRES  13 B  321  VAL TYR LEU ASP CYS ILE ARG ALA LEU ASP PHE VAL CYS
SEQRES  14 B  321  SER ARG GLU GLU VAL ASP ALA SER ARG ILE ALA VAL TYR
SEQRES  15 B  321  GLY GLY SER GLN GLY GLY GLY LEU ALA LEU ALA ALA ALA
SEQRES  16 B  321  GLY LEU ASP SER ARG PRO LYS LEU ALA LEU PRO VAL PHE
SEQRES  17 B  321  PRO PHE LEU CYS HIS PHE ARG ARG SER VAL GLU ILE HIS
SEQRES  18 B  321  ALA SER GLY PRO TYR VAL GLU ILE LYS ASN TRP PHE ARG
SEQRES  19 B  321  ARG TYR ASP PRO GLU HIS ARG GLN GLU GLU GLN VAL TYR
SEQRES  20 B  321  ARG THR LEU SER TYR PHE ASP GLY MET ASN MET ALA SER
SEQRES  21 B  321  ARG ILE LYS ALA ARG THR LEU MET ALA ILE THR LEU GLN
SEQRES  22 B  321  ASP ILE THR CYS PRO PRO SER THR CYS PHE ALA ALA TYR
SEQRES  23 B  321  ASN HIS LEU ALA GLY PRO LYS GLU VAL ARG LEU TYR HIS
SEQRES  24 B  321  ASP TYR GLY HIS GLU GLY LEU PRO PHE HIS GLU GLU ALA
SEQRES  25 B  321  MET MET ARG PHE ILE GLU ALA TYR LEU
SEQRES   1 C  321  MET PRO ASN VAL ASP MET PRO LEU SER GLN LEU GLN ASP
SEQRES   2 C  321  TYR LYS PRO GLU LEU THR ASN GLU THR ASP PHE ASP LEU
SEQRES   3 C  321  PHE TRP ASP ASN ALA LYS ALA LEU SER ASN GLN LYS PRO
SEQRES   4 C  321  LEU HIS ALA GLN VAL ASN LEU VAL GLN ASP TYR PRO LEU
SEQRES   5 C  321  LYS SER ILE SER ILE TYR ASP VAL VAL TYR ASP GLY ALA
SEQRES   6 C  321  ASP GLY THR PRO ILE HIS GLY TRP TYR VAL THR PRO LYS
SEQRES   7 C  321  GLY GLU HIS GLN PRO GLY SER LEU PRO VAL LEU VAL LYS
SEQRES   8 C  321  TYR HIS GLY TYR SER GLY ASN ARG GLY TYR PRO ASN GLU
SEQRES   9 C  321  LEU LEU GLN TRP ALA SER MET GLY MET ALA ALA LEU ALA
SEQRES  10 C  321  ILE ASP VAL ARG GLY GLN GLY GLY VAL THR PRO ASP ARG
SEQRES  11 C  321  ALA GLU TYR PRO GLN GLY GLY ILE PRO GLY TRP MET THR
SEQRES  12 C  321  LEU GLY ILE LEU ASP PRO ALA SER TYR TYR TYR LYS GLN
SEQRES  13 C  321  VAL TYR LEU ASP CYS ILE ARG ALA LEU ASP PHE VAL CYS
SEQRES  14 C  321  SER ARG GLU GLU VAL ASP ALA SER ARG ILE ALA VAL TYR
SEQRES  15 C  321  GLY GLY SER GLN GLY GLY GLY LEU ALA LEU ALA ALA ALA
SEQRES  16 C  321  GLY LEU ASP SER ARG PRO LYS LEU ALA LEU PRO VAL PHE
SEQRES  17 C  321  PRO PHE LEU CYS HIS PHE ARG ARG SER VAL GLU ILE HIS
SEQRES  18 C  321  ALA SER GLY PRO TYR VAL GLU ILE LYS ASN TRP PHE ARG
SEQRES  19 C  321  ARG TYR ASP PRO GLU HIS ARG GLN GLU GLU GLN VAL TYR
SEQRES  20 C  321  ARG THR LEU SER TYR PHE ASP GLY MET ASN MET ALA SER
SEQRES  21 C  321  ARG ILE LYS ALA ARG THR LEU MET ALA ILE THR LEU GLN
SEQRES  22 C  321  ASP ILE THR CYS PRO PRO SER THR CYS PHE ALA ALA TYR
SEQRES  23 C  321  ASN HIS LEU ALA GLY PRO LYS GLU VAL ARG LEU TYR HIS
SEQRES  24 C  321  ASP TYR GLY HIS GLU GLY LEU PRO PHE HIS GLU GLU ALA
SEQRES  25 C  321  MET MET ARG PHE ILE GLU ALA TYR LEU
SEQRES   1 D  321  MET PRO ASN VAL ASP MET PRO LEU SER GLN LEU GLN ASP
SEQRES   2 D  321  TYR LYS PRO GLU LEU THR ASN GLU THR ASP PHE ASP LEU
SEQRES   3 D  321  PHE TRP ASP ASN ALA LYS ALA LEU SER ASN GLN LYS PRO
SEQRES   4 D  321  LEU HIS ALA GLN VAL ASN LEU VAL GLN ASP TYR PRO LEU
SEQRES   5 D  321  LYS SER ILE SER ILE TYR ASP VAL VAL TYR ASP GLY ALA
SEQRES   6 D  321  ASP GLY THR PRO ILE HIS GLY TRP TYR VAL THR PRO LYS
SEQRES   7 D  321  GLY GLU HIS GLN PRO GLY SER LEU PRO VAL LEU VAL LYS
SEQRES   8 D  321  TYR HIS GLY TYR SER GLY ASN ARG GLY TYR PRO ASN GLU
SEQRES   9 D  321  LEU LEU GLN TRP ALA SER MET GLY MET ALA ALA LEU ALA
SEQRES  10 D  321  ILE ASP VAL ARG GLY GLN GLY GLY VAL THR PRO ASP ARG
SEQRES  11 D  321  ALA GLU TYR PRO GLN GLY GLY ILE PRO GLY TRP MET THR
SEQRES  12 D  321  LEU GLY ILE LEU ASP PRO ALA SER TYR TYR TYR LYS GLN
SEQRES  13 D  321  VAL TYR LEU ASP CYS ILE ARG ALA LEU ASP PHE VAL CYS
SEQRES  14 D  321  SER ARG GLU GLU VAL ASP ALA SER ARG ILE ALA VAL TYR
SEQRES  15 D  321  GLY GLY SER GLN GLY GLY GLY LEU ALA LEU ALA ALA ALA
SEQRES  16 D  321  GLY LEU ASP SER ARG PRO LYS LEU ALA LEU PRO VAL PHE
SEQRES  17 D  321  PRO PHE LEU CYS HIS PHE ARG ARG SER VAL GLU ILE HIS
SEQRES  18 D  321  ALA SER GLY PRO TYR VAL GLU ILE LYS ASN TRP PHE ARG
SEQRES  19 D  321  ARG TYR ASP PRO GLU HIS ARG GLN GLU GLU GLN VAL TYR
SEQRES  20 D  321  ARG THR LEU SER TYR PHE ASP GLY MET ASN MET ALA SER
SEQRES  21 D  321  ARG ILE LYS ALA ARG THR LEU MET ALA ILE THR LEU GLN
SEQRES  22 D  321  ASP ILE THR CYS PRO PRO SER THR CYS PHE ALA ALA TYR
SEQRES  23 D  321  ASN HIS LEU ALA GLY PRO LYS GLU VAL ARG LEU TYR HIS
SEQRES  24 D  321  ASP TYR GLY HIS GLU GLY LEU PRO PHE HIS GLU GLU ALA
SEQRES  25 D  321  MET MET ARG PHE ILE GLU ALA TYR LEU
SEQRES   1 E  321  MET PRO ASN VAL ASP MET PRO LEU SER GLN LEU GLN ASP
SEQRES   2 E  321  TYR LYS PRO GLU LEU THR ASN GLU THR ASP PHE ASP LEU
SEQRES   3 E  321  PHE TRP ASP ASN ALA LYS ALA LEU SER ASN GLN LYS PRO
SEQRES   4 E  321  LEU HIS ALA GLN VAL ASN LEU VAL GLN ASP TYR PRO LEU
SEQRES   5 E  321  LYS SER ILE SER ILE TYR ASP VAL VAL TYR ASP GLY ALA
SEQRES   6 E  321  ASP GLY THR PRO ILE HIS GLY TRP TYR VAL THR PRO LYS
SEQRES   7 E  321  GLY GLU HIS GLN PRO GLY SER LEU PRO VAL LEU VAL LYS
SEQRES   8 E  321  TYR HIS GLY TYR SER GLY ASN ARG GLY TYR PRO ASN GLU
SEQRES   9 E  321  LEU LEU GLN TRP ALA SER MET GLY MET ALA ALA LEU ALA
SEQRES  10 E  321  ILE ASP VAL ARG GLY GLN GLY GLY VAL THR PRO ASP ARG
SEQRES  11 E  321  ALA GLU TYR PRO GLN GLY GLY ILE PRO GLY TRP MET THR
SEQRES  12 E  321  LEU GLY ILE LEU ASP PRO ALA SER TYR TYR TYR LYS GLN
SEQRES  13 E  321  VAL TYR LEU ASP CYS ILE ARG ALA LEU ASP PHE VAL CYS
SEQRES  14 E  321  SER ARG GLU GLU VAL ASP ALA SER ARG ILE ALA VAL TYR
SEQRES  15 E  321  GLY GLY SER GLN GLY GLY GLY LEU ALA LEU ALA ALA ALA
SEQRES  16 E  321  GLY LEU ASP SER ARG PRO LYS LEU ALA LEU PRO VAL PHE
SEQRES  17 E  321  PRO PHE LEU CYS HIS PHE ARG ARG SER VAL GLU ILE HIS
SEQRES  18 E  321  ALA SER GLY PRO TYR VAL GLU ILE LYS ASN TRP PHE ARG
SEQRES  19 E  321  ARG TYR ASP PRO GLU HIS ARG GLN GLU GLU GLN VAL TYR
SEQRES  20 E  321  ARG THR LEU SER TYR PHE ASP GLY MET ASN MET ALA SER
SEQRES  21 E  321  ARG ILE LYS ALA ARG THR LEU MET ALA ILE THR LEU GLN
SEQRES  22 E  321  ASP ILE THR CYS PRO PRO SER THR CYS PHE ALA ALA TYR
SEQRES  23 E  321  ASN HIS LEU ALA GLY PRO LYS GLU VAL ARG LEU TYR HIS
SEQRES  24 E  321  ASP TYR GLY HIS GLU GLY LEU PRO PHE HIS GLU GLU ALA
SEQRES  25 E  321  MET MET ARG PHE ILE GLU ALA TYR LEU
SEQRES   1 F  321  MET PRO ASN VAL ASP MET PRO LEU SER GLN LEU GLN ASP
SEQRES   2 F  321  TYR LYS PRO GLU LEU THR ASN GLU THR ASP PHE ASP LEU
SEQRES   3 F  321  PHE TRP ASP ASN ALA LYS ALA LEU SER ASN GLN LYS PRO
SEQRES   4 F  321  LEU HIS ALA GLN VAL ASN LEU VAL GLN ASP TYR PRO LEU
SEQRES   5 F  321  LYS SER ILE SER ILE TYR ASP VAL VAL TYR ASP GLY ALA
SEQRES   6 F  321  ASP GLY THR PRO ILE HIS GLY TRP TYR VAL THR PRO LYS
SEQRES   7 F  321  GLY GLU HIS GLN PRO GLY SER LEU PRO VAL LEU VAL LYS
SEQRES   8 F  321  TYR HIS GLY TYR SER GLY ASN ARG GLY TYR PRO ASN GLU
SEQRES   9 F  321  LEU LEU GLN TRP ALA SER MET GLY MET ALA ALA LEU ALA
SEQRES  10 F  321  ILE ASP VAL ARG GLY GLN GLY GLY VAL THR PRO ASP ARG
SEQRES  11 F  321  ALA GLU TYR PRO GLN GLY GLY ILE PRO GLY TRP MET THR
SEQRES  12 F  321  LEU GLY ILE LEU ASP PRO ALA SER TYR TYR TYR LYS GLN
SEQRES  13 F  321  VAL TYR LEU ASP CYS ILE ARG ALA LEU ASP PHE VAL CYS
SEQRES  14 F  321  SER ARG GLU GLU VAL ASP ALA SER ARG ILE ALA VAL TYR
SEQRES  15 F  321  GLY GLY SER GLN GLY GLY GLY LEU ALA LEU ALA ALA ALA
SEQRES  16 F  321  GLY LEU ASP SER ARG PRO LYS LEU ALA LEU PRO VAL PHE
SEQRES  17 F  321  PRO PHE LEU CYS HIS PHE ARG ARG SER VAL GLU ILE HIS
SEQRES  18 F  321  ALA SER GLY PRO TYR VAL GLU ILE LYS ASN TRP PHE ARG
SEQRES  19 F  321  ARG TYR ASP PRO GLU HIS ARG GLN GLU GLU GLN VAL TYR
SEQRES  20 F  321  ARG THR LEU SER TYR PHE ASP GLY MET ASN MET ALA SER
SEQRES  21 F  321  ARG ILE LYS ALA ARG THR LEU MET ALA ILE THR LEU GLN
SEQRES  22 F  321  ASP ILE THR CYS PRO PRO SER THR CYS PHE ALA ALA TYR
SEQRES  23 F  321  ASN HIS LEU ALA GLY PRO LYS GLU VAL ARG LEU TYR HIS
SEQRES  24 F  321  ASP TYR GLY HIS GLU GLY LEU PRO PHE HIS GLU GLU ALA
SEQRES  25 F  321  MET MET ARG PHE ILE GLU ALA TYR LEU
HET     ZN  A 401       1
HET     ZN  B 401       1
HET     ZN  C 401       1
HET     ZN  D 401       1
HET     ZN  E 401       1
HET     ZN  F 401       1
HETNAM      ZN ZINC ION
FORMUL   7   ZN    6(ZN 2+)
FORMUL  13  HOH   *767(H2 O)
HELIX    1 AA1 PRO A    7  GLN A   12  1                                   6
HELIX    2 AA2 ASP A   23  GLN A   37  1                                  15
HELIX    3 AA3 TYR A  101  GLU A  104  5                                   4
HELIX    4 AA4 LEU A  105  MET A  111  1                                   7
HELIX    5 AA5 ASP A  148  SER A  151  5                                   4
HELIX    6 AA6 TYR A  152  ARG A  171  1                                  20
HELIX    7 AA7 SER A  185  ASP A  198  1                                  14
HELIX    8 AA8 HIS A  213  ILE A  220  1                                   8
HELIX    9 AA9 PRO A  225  ASP A  237  1                                  13
HELIX   10 AB1 GLN A  242  TYR A  252  1                                  11
HELIX   11 AB2 ASP A  254  SER A  260  1                                   7
HELIX   12 AB3 PRO A  278  ASN A  287  1                                  10
HELIX   13 AB4 PHE A  308  LEU A  321  1                                  14
HELIX   14 AB5 PRO B    7  ASP B   13  1                                   7
HELIX   15 AB6 ASP B   23  GLN B   37  1                                  15
HELIX   16 AB7 TYR B  101  GLU B  104  5                                   4
HELIX   17 AB8 LEU B  105  MET B  111  1                                   7
HELIX   18 AB9 ASP B  148  SER B  151  5                                   4
HELIX   19 AC1 TYR B  152  SER B  170  1                                  19
HELIX   20 AC2 SER B  185  ASP B  198  1                                  14
HELIX   21 AC3 HIS B  213  ILE B  220  1                                   8
HELIX   22 AC4 SER B  223  PRO B  225  5                                   3
HELIX   23 AC5 TYR B  226  ASP B  237  1                                  12
HELIX   24 AC6 GLN B  242  TYR B  252  1                                  11
HELIX   25 AC7 ASP B  254  SER B  260  1                                   7
HELIX   26 AC8 PRO B  278  ASN B  287  1                                  10
HELIX   27 AC9 PHE B  308  LEU B  321  1                                  14
HELIX   28 AD1 PRO C    7  ASP C   13  1                                   7
HELIX   29 AD2 ASP C   23  GLN C   37  1                                  15
HELIX   30 AD3 TYR C  101  GLU C  104  5                                   4
HELIX   31 AD4 LEU C  105  MET C  111  1                                   7
HELIX   32 AD5 TYR C  152  SER C  170  1                                  19
HELIX   33 AD6 SER C  185  ASP C  198  1                                  14
HELIX   34 AD7 HIS C  213  ILE C  220  1                                   8
HELIX   35 AD8 SER C  223  PRO C  225  5                                   3
HELIX   36 AD9 TYR C  226  ASP C  237  1                                  12
HELIX   37 AE1 GLN C  242  TYR C  252  1                                  11
HELIX   38 AE2 ASP C  254  SER C  260  1                                   7
HELIX   39 AE3 PRO C  278  ASN C  287  1                                  10
HELIX   40 AE4 LEU C  306  LEU C  321  1                                  16
HELIX   41 AE5 PRO D    7  ASP D   13  1                                   7
HELIX   42 AE6 ASP D   23  LYS D   38  1                                  16
HELIX   43 AE7 TYR D  101  GLU D  104  5                                   4
HELIX   44 AE8 LEU D  105  MET D  111  1                                   7
HELIX   45 AE9 TYR D  152  SER D  170  1                                  19
HELIX   46 AF1 SER D  185  ASP D  198  1                                  14
HELIX   47 AF2 HIS D  213  ILE D  220  1                                   8
HELIX   48 AF3 SER D  223  PRO D  225  5                                   3
HELIX   49 AF4 TYR D  226  ASP D  237  1                                  12
HELIX   50 AF5 GLN D  242  TYR D  252  1                                  11
HELIX   51 AF6 ASP D  254  SER D  260  1                                   7
HELIX   52 AF7 PRO D  278  ASN D  287  1                                  10
HELIX   53 AF8 LEU D  306  LEU D  321  1                                  16
HELIX   54 AF9 PRO E    7  GLN E   12  1                                   6
HELIX   55 AG1 ASP E   23  GLN E   37  1                                  15
HELIX   56 AG2 TYR E  101  GLU E  104  5                                   4
HELIX   57 AG3 LEU E  105  MET E  111  1                                   7
HELIX   58 AG4 ASP E  148  SER E  151  5                                   4
HELIX   59 AG5 TYR E  152  SER E  170  1                                  19
HELIX   60 AG6 SER E  185  ASP E  198  1                                  14
HELIX   61 AG7 HIS E  213  ILE E  220  1                                   8
HELIX   62 AG8 PRO E  225  ASP E  237  1                                  13
HELIX   63 AG9 GLN E  242  TYR E  252  1                                  11
HELIX   64 AH1 ASP E  254  SER E  260  1                                   7
HELIX   65 AH2 PRO E  278  ASN E  287  1                                  10
HELIX   66 AH3 PHE E  308  LEU E  321  1                                  14
HELIX   67 AH4 PRO F    7  TYR F   14  1                                   8
HELIX   68 AH5 ASP F   23  GLN F   37  1                                  15
HELIX   69 AH6 TYR F  101  GLU F  104  5                                   4
HELIX   70 AH7 LEU F  105  MET F  111  1                                   7
HELIX   71 AH8 ASP F  148  SER F  151  5                                   4
HELIX   72 AH9 TYR F  152  SER F  170  1                                  19
HELIX   73 AI1 SER F  185  ASP F  198  1                                  14
HELIX   74 AI2 HIS F  213  ILE F  220  1                                   8
HELIX   75 AI3 SER F  223  PRO F  225  5                                   3
HELIX   76 AI4 TYR F  226  ASP F  237  1                                  12
HELIX   77 AI5 GLN F  242  TYR F  252  1                                  11
HELIX   78 AI6 ASP F  254  SER F  260  1                                   7
HELIX   79 AI7 PRO F  278  ASN F  287  1                                  10
HELIX   80 AI8 PHE F  308  LEU F  321  1                                  14
SHEET    1 AA1 9 GLN A  43  LEU A  46  0
SHEET    2 AA1 9 ILE A  55  ASP A  63 -1  O  VAL A  61   N  GLN A  43
SHEET    3 AA1 9 PRO A  69  PRO A  77 -1  O  ILE A  70   N  TYR A  62
SHEET    4 AA1 9 ALA A 114  ILE A 118 -1  O  ALA A 115   N  VAL A  75
SHEET    5 AA1 9 LEU A  86  TYR A  92  1  N  LYS A  91   O  LEU A 116
SHEET    6 AA1 9 VAL A 174  GLY A 184  1  O  ASP A 175   N  LEU A  86
SHEET    7 AA1 9 LEU A 203  VAL A 207  1  O  LEU A 205   N  VAL A 181
SHEET    8 AA1 9 ARG A 265  THR A 271  1  O  LEU A 267   N  ALA A 204
SHEET    9 AA1 9 LYS A 293  TYR A 298  1  O  ARG A 296   N  ILE A 270
SHEET    1 AA2 9 GLN B  43  VAL B  47  0
SHEET    2 AA2 9 ILE B  55  ASP B  63 -1  O  ILE B  57   N  VAL B  47
SHEET    3 AA2 9 PRO B  69  PRO B  77 -1  O  ILE B  70   N  TYR B  62
SHEET    4 AA2 9 ALA B 114  ILE B 118 -1  O  ALA B 115   N  VAL B  75
SHEET    5 AA2 9 LEU B  86  TYR B  92  1  N  PRO B  87   O  ALA B 114
SHEET    6 AA2 9 VAL B 174  GLY B 184  1  O  ASP B 175   N  LEU B  86
SHEET    7 AA2 9 LEU B 203  VAL B 207  1  O  LEU B 205   N  VAL B 181
SHEET    8 AA2 9 ARG B 265  THR B 271  1  O  LEU B 267   N  ALA B 204
SHEET    9 AA2 9 LYS B 293  TYR B 298  1  O  ARG B 296   N  ILE B 270
SHEET    1 AA3 9 GLN C  43  LEU C  46  0
SHEET    2 AA3 9 ILE C  55  ASP C  63 -1  O  VAL C  61   N  GLN C  43
SHEET    3 AA3 9 PRO C  69  PRO C  77 -1  O  TYR C  74   N  TYR C  58
SHEET    4 AA3 9 ALA C 114  ILE C 118 -1  O  ALA C 115   N  VAL C  75
SHEET    5 AA3 9 LEU C  86  TYR C  92  1  N  PRO C  87   O  ALA C 114
SHEET    6 AA3 9 VAL C 174  GLY C 184  1  O  ASP C 175   N  LEU C  86
SHEET    7 AA3 9 LEU C 203  VAL C 207  1  O  VAL C 207   N  GLY C 183
SHEET    8 AA3 9 ARG C 265  THR C 271  1  O  ARG C 265   N  ALA C 204
SHEET    9 AA3 9 LYS C 293  TYR C 298  1  O  ARG C 296   N  ILE C 270
SHEET    1 AA4 9 GLN D  43  LEU D  46  0
SHEET    2 AA4 9 ILE D  55  ASP D  63 -1  O  VAL D  61   N  GLN D  43
SHEET    3 AA4 9 PRO D  69  PRO D  77 -1  O  TYR D  74   N  TYR D  58
SHEET    4 AA4 9 ALA D 114  ILE D 118 -1  O  ALA D 115   N  VAL D  75
SHEET    5 AA4 9 LEU D  86  TYR D  92  1  N  LYS D  91   O  LEU D 116
SHEET    6 AA4 9 VAL D 174  GLY D 184  1  O  ARG D 178   N  VAL D  88
SHEET    7 AA4 9 LEU D 203  VAL D 207  1  O  VAL D 207   N  GLY D 183
SHEET    8 AA4 9 ARG D 265  THR D 271  1  O  LEU D 267   N  ALA D 204
SHEET    9 AA4 9 LYS D 293  TYR D 298  1  O  TYR D 298   N  ILE D 270
SHEET    1 AA5 9 GLN E  43  LEU E  46  0
SHEET    2 AA5 9 ILE E  55  ASP E  63 -1  O  ASP E  59   N  ASN E  45
SHEET    3 AA5 9 PRO E  69  PRO E  77 -1  O  ILE E  70   N  TYR E  62
SHEET    4 AA5 9 ALA E 114  ILE E 118 -1  O  ALA E 115   N  VAL E  75
SHEET    5 AA5 9 LEU E  86  TYR E  92  1  N  LYS E  91   O  LEU E 116
SHEET    6 AA5 9 VAL E 174  GLY E 184  1  O  ALA E 180   N  VAL E  90
SHEET    7 AA5 9 LEU E 203  VAL E 207  1  O  LEU E 205   N  VAL E 181
SHEET    8 AA5 9 ARG E 265  THR E 271  1  O  LEU E 267   N  ALA E 204
SHEET    9 AA5 9 LYS E 293  TYR E 298  1  O  ARG E 296   N  ILE E 270
SHEET    1 AA6 8 ILE F  55  ASP F  63  0
SHEET    2 AA6 8 PRO F  69  PRO F  77 -1  O  THR F  76   N  SER F  56
SHEET    3 AA6 8 ALA F 114  ILE F 118 -1  O  ALA F 115   N  VAL F  75
SHEET    4 AA6 8 LEU F  86  LYS F  91  1  N  LYS F  91   O  LEU F 116
SHEET    5 AA6 8 VAL F 174  GLY F 184  1  O  ALA F 180   N  VAL F  90
SHEET    6 AA6 8 LEU F 203  VAL F 207  1  O  LEU F 205   N  VAL F 181
SHEET    7 AA6 8 ARG F 265  THR F 271  1  O  ARG F 265   N  ALA F 204
SHEET    8 AA6 8 LYS F 293  TYR F 298  1  O  TYR F 298   N  ILE F 270
SITE     1 AC1  1 TYR A 247
SITE     1 AC2  1 TYR B 247
SITE     1 AC3  1 TYR C 247
SITE     1 AC4  1 TYR D 247
SITE     1 AC5  2 TYR F 247  ASP F 254
CRYST1  153.797  141.659  105.369  90.00 104.49  90.00 C 1 2 1      24
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.006502  0.000000  0.001681        0.00000
SCALE2      0.000000  0.007059  0.000000        0.00000
SCALE3      0.000000  0.000000  0.009802        0.00000
TER    2511      LEU A 321
TER    5022      LEU B 321
TER    7533      LEU C 321
TER   10044      LEU D 321
TER   12555      LEU E 321
TER   15066      LEU F 321
MASTER      390    0    6   80   53    0    5    615833    6    0  150
END