longtext: 6aid-pdb

content
HEADER    HYDROLASE                               22-AUG-18   6AID
TITLE     STRUCTURAL INSIGHTS INTO THE UNIQUE POLYLACTATE DEGRADING MECHANISM OF
TITLE    2 THERMOBIFIDA ALBA CUTINASE
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: ESTERASE;
COMPND   3 CHAIN: A;
COMPND   4 FRAGMENT: UNP RESIDUES 35-300;
COMPND   5 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: THERMOBIFIDA ALBA;
SOURCE   3 ORGANISM_TAXID: 53522;
SOURCE   4 GENE: EST2;
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 562
KEYWDS    HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    K.KITADOKORO,M.KAKARA,S.MATSUI,R.OSOKOSHI,U.THUMARAT,F.KAWAI,
AUTHOR   2 S.KAMITANI
REVDAT   1   27-FEB-19 6AID    0
JRNL        AUTH   K.KITADOKORO,K.MIZUKI,S.MATSUI,R.OSOKOSHI,T.USCHARA,F.KAWAI,
JRNL        AUTH 2 S.KAMITANI
JRNL        TITL   STRUCTURAL INSIGHTS INTO THE UNIQUE POLYLACTATE-DEGRADING
JRNL        TITL 2 MECHANISM OF THERMOBIFIDA ALBA CUTINASE.
JRNL        REF    FEBS J.                                    2019
JRNL        REFN                   ISSN 1742-4658
JRNL        PMID   30761732
JRNL        DOI    10.1111/FEBS.14781
REMARK   2
REMARK   2 RESOLUTION.    1.30 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.8.0155
REMARK   3   AUTHORS     : MURSHUDOV,SKUBAK,LEBEDEV,PANNU,STEINER,
REMARK   3               : NICHOLLS,WINN,LONG,VAGIN
REMARK   3
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.30
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 50.00
REMARK   3   DATA CUTOFF            (SIGMA(F)) : NULL
REMARK   3   COMPLETENESS FOR RANGE        (%) : 97.9
REMARK   3   NUMBER OF REFLECTIONS             : 53071
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.135
REMARK   3   R VALUE            (WORKING SET) : 0.133
REMARK   3   FREE R VALUE                     : 0.165
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.000
REMARK   3   FREE R VALUE TEST SET COUNT      : 2790
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 1.30
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 1.34
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 3245
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 82.56
REMARK   3   BIN R VALUE           (WORKING SET) : 0.3650
REMARK   3   BIN FREE R VALUE SET COUNT          : 178
REMARK   3   BIN FREE R VALUE                    : 0.3850
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 2009
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 19
REMARK   3   SOLVENT ATOMS            : 222
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 17.50
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 12.26
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : 0.23000
REMARK   3    B22 (A**2) : -0.15000
REMARK   3    B33 (A**2) : -0.08000
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : 0.00000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): 0.046
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.045
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.032
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 1.786
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.979
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.969
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A):  2073 ; 0.030 ; 0.019
REMARK   3   BOND LENGTHS OTHERS               (A):  1907 ; 0.003 ; 0.020
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES):  2821 ; 2.443 ; 1.957
REMARK   3   BOND ANGLES OTHERS          (DEGREES):  4387 ; 1.251 ; 3.000
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):   260 ; 6.510 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):    91 ;31.259 ;22.747
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):   312 ; 9.808 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):    18 ;18.881 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):   309 ; 0.167 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A):  2361 ; 0.016 ; 0.021
REMARK   3   GENERAL PLANES OTHERS             (A):   483 ; 0.002 ; 0.020
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  1043 ; 0.952 ; 0.336
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  1042 ; 0.951 ; 0.333
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  1302 ; 1.215 ; 0.505
REMARK   3   MAIN-CHAIN ANGLE OTHER ATOMS   (A**2):  1303 ; 1.215 ; 0.508
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  1030 ; 1.967 ; 0.589
REMARK   3   SIDE-CHAIN BOND OTHER ATOMS    (A**2):  1031 ; 1.971 ; 0.591
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN ANGLE OTHER ATOMS   (A**2):  1520 ; 2.249 ; 0.798
REMARK   3   LONG RANGE B REFINED ATOMS     (A**2):  2427 ; 2.318 ; 6.069
REMARK   3   LONG RANGE B OTHER ATOMS       (A**2):  2428 ; 2.320 ; 6.091
REMARK   3
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  3980 ; 6.020 ; 3.000
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):   125 ;16.969 ; 5.000
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  4032 ; 4.767 ; 5.000
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : 8
REMARK   3
REMARK   3   TLS GROUP : 1
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   A    40        A   300
REMARK   3    ORIGIN FOR THE GROUP (A):   1.9999  -3.6755  11.8091
REMARK   3    T TENSOR
REMARK   3      T11:   0.0492 T22:   0.0745
REMARK   3      T33:   0.0646 T12:  -0.0030
REMARK   3      T13:   0.0022 T23:  -0.0032
REMARK   3    L TENSOR
REMARK   3      L11:   0.3525 L22:   0.3048
REMARK   3      L33:   0.4531 L12:  -0.0305
REMARK   3      L13:  -0.0755 L23:  -0.0129
REMARK   3    S TENSOR
REMARK   3      S11:   0.0120 S12:   0.0020 S13:   0.0274
REMARK   3      S21:   0.0026 S22:   0.0120 S23:  -0.0017
REMARK   3      S31:  -0.0136 S32:  -0.0026 S33:  -0.0239
REMARK   3
REMARK   3   TLS GROUP : 2
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   A   401        A   401
REMARK   3    ORIGIN FOR THE GROUP (A): -17.0338  -1.1930  24.8988
REMARK   3    T TENSOR
REMARK   3      T11:   0.0294 T22:   0.1505
REMARK   3      T33:   0.0610 T12:   0.0560
REMARK   3      T13:   0.0329 T23:   0.0304
REMARK   3    L TENSOR
REMARK   3      L11:   0.0000 L22:   0.0000
REMARK   3      L33:   0.0000 L12:   0.0000
REMARK   3      L13:   0.0000 L23:   0.0000
REMARK   3    S TENSOR
REMARK   3      S11:   0.0000 S12:   0.0000 S13:   0.0000
REMARK   3      S21:   0.0000 S22:   0.0000 S23:   0.0000
REMARK   3      S31:   0.0000 S32:   0.0000 S33:   0.0000
REMARK   3
REMARK   3   TLS GROUP : 3
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   A   402        A   402
REMARK   3    ORIGIN FOR THE GROUP (A):  -1.0840 -19.0567  -0.2820
REMARK   3    T TENSOR
REMARK   3      T11:   0.0348 T22:   0.0682
REMARK   3      T33:   0.0690 T12:  -0.0180
REMARK   3      T13:  -0.0111 T23:  -0.0131
REMARK   3    L TENSOR
REMARK   3      L11:   0.0000 L22:   0.0000
REMARK   3      L33:   0.0000 L12:   0.0000
REMARK   3      L13:   0.0000 L23:   0.0000
REMARK   3    S TENSOR
REMARK   3      S11:   0.0000 S12:   0.0000 S13:   0.0000
REMARK   3      S21:   0.0000 S22:   0.0000 S23:   0.0000
REMARK   3      S31:   0.0000 S32:   0.0000 S33:   0.0000
REMARK   3
REMARK   3   TLS GROUP : 4
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   A   403        A   403
REMARK   3    ORIGIN FOR THE GROUP (A):  19.3838 -16.6017  14.5874
REMARK   3    T TENSOR
REMARK   3      T11:   0.0553 T22:   0.0600
REMARK   3      T33:   0.0772 T12:   0.0158
REMARK   3      T13:  -0.0060 T23:  -0.0223
REMARK   3    L TENSOR
REMARK   3      L11:   0.0000 L22:   0.0000
REMARK   3      L33:   0.0000 L12:   0.0000
REMARK   3      L13:   0.0000 L23:   0.0000
REMARK   3    S TENSOR
REMARK   3      S11:   0.0000 S12:   0.0000 S13:   0.0000
REMARK   3      S21:   0.0000 S22:   0.0000 S23:   0.0000
REMARK   3      S31:   0.0000 S32:   0.0000 S33:   0.0000
REMARK   3
REMARK   3   TLS GROUP : 5
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   A   501        A   722
REMARK   3    ORIGIN FOR THE GROUP (A):   1.1601  -4.0208   8.9585
REMARK   3    T TENSOR
REMARK   3      T11:   0.0194 T22:   0.0445
REMARK   3      T33:   0.0399 T12:  -0.0075
REMARK   3      T13:   0.0001 T23:   0.0012
REMARK   3    L TENSOR
REMARK   3      L11:   0.3883 L22:   0.3473
REMARK   3      L33:   0.3383 L12:  -0.0812
REMARK   3      L13:  -0.0497 L23:  -0.0686
REMARK   3    S TENSOR
REMARK   3      S11:   0.0191 S12:   0.0093 S13:   0.0200
REMARK   3      S21:  -0.0159 S22:   0.0156 S23:   0.0096
REMARK   3      S31:   0.0077 S32:  -0.0168 S33:  -0.0347
REMARK   3
REMARK   3   TLS GROUP : 6
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   A   404        A   404
REMARK   3    ORIGIN FOR THE GROUP (A):   1.7202 -13.1743  24.9539
REMARK   3    T TENSOR
REMARK   3      T11:   0.0581 T22:   0.0981
REMARK   3      T33:   0.0829 T12:   0.0121
REMARK   3      T13:   0.0038 T23:   0.0238
REMARK   3    L TENSOR
REMARK   3      L11:  16.5072 L22:  10.6952
REMARK   3      L33:   1.7855 L12:   8.1381
REMARK   3      L13:  -1.9002 L23:   2.2990
REMARK   3    S TENSOR
REMARK   3      S11:  -0.4479 S12:   0.2103 S13:   0.2119
REMARK   3      S21:  -0.0730 S22:   0.1568 S23:   0.7548
REMARK   3      S31:   0.1228 S32:   0.0029 S33:   0.2911
REMARK   3
REMARK   3   TLS GROUP : 7
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   A   405        A   406
REMARK   3    ORIGIN FOR THE GROUP (A):  -4.3545  -1.7290  26.9348
REMARK   3    T TENSOR
REMARK   3      T11:   0.0719 T22:   0.0928
REMARK   3      T33:   0.1029 T12:   0.0056
REMARK   3      T13:   0.0124 T23:   0.0068
REMARK   3    L TENSOR
REMARK   3      L11:   1.5082 L22:   0.5021
REMARK   3      L33:   1.8376 L12:   0.8345
REMARK   3      L13:  -1.6622 L23:  -0.9346
REMARK   3    S TENSOR
REMARK   3      S11:   0.0177 S12:  -0.0300 S13:   0.0076
REMARK   3      S21:   0.0109 S22:  -0.0108 S23:   0.0086
REMARK   3      S31:  -0.0166 S32:   0.0345 S33:  -0.0069
REMARK   3
REMARK   3   TLS GROUP : 8
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   A   407        A   407
REMARK   3    ORIGIN FOR THE GROUP (A):   4.2384  -9.9313  30.3635
REMARK   3    T TENSOR
REMARK   3      T11:   0.0446 T22:   0.1942
REMARK   3      T33:   0.1010 T12:   0.0638
REMARK   3      T13:  -0.0487 T23:  -0.1101
REMARK   3    L TENSOR
REMARK   3      L11:  39.8810 L22: 265.6608
REMARK   3      L33: 131.3804 L12:  30.3904
REMARK   3      L13: -69.0348 L23:   1.0670
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0902 S12:  -0.7215 S13:  -0.7453
REMARK   3      S21:   2.0993 S22:  -1.1051 S23:  -1.0059
REMARK   3      S31:   0.6363 S32:   1.1237 S33:   1.1954
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : MASK
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.20
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE RIDING
REMARK   3  POSITIONS.
REMARK   4
REMARK   4 6AID COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 30-AUG-18.
REMARK 100 THE DEPOSITION ID IS D_1300008825.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 08-DEC-15
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : NULL
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : SPRING-8
REMARK 200  BEAMLINE                       : BL44XU
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : RAYONIX MX300HE
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200  DATA SCALING SOFTWARE          : XSCALE
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 106239
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.300
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 97.6
REMARK 200  DATA REDUNDANCY                : 3.500
REMARK 200  R MERGE                    (I) : 0.12100
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 7.4100
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.30
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.38
REMARK 200  COMPLETENESS FOR SHELL     (%) : 86.7
REMARK 200  DATA REDUNDANCY IN SHELL       : 1.89
REMARK 200  R MERGE FOR SHELL          (I) : NULL
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 0.910
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MIR
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: PLATE LIKE
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 34.91
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 1.89
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 15-20% (W/V) PEG 3350, 0.2 M SODIUM
REMARK 280  ACETATE, 0.2M2 M CALCIUM CHLORIDE, AND 0.1 M SODIUM CHLORIDE, PH
REMARK 280  8.0, VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 293K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X+1/2,-Y,Z+1/2
REMARK 290       3555   -X,Y+1/2,-Z+1/2
REMARK 290       4555   X+1/2,-Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       21.13250
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       39.29700
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       34.43000
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       39.29700
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       21.13250
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       34.43000
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 130 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 10270 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -13.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A    23
REMARK 465     ARG A    24
REMARK 465     GLY A    25
REMARK 465     SER A    26
REMARK 465     HIS A    27
REMARK 465     HIS A    28
REMARK 465     HIS A    29
REMARK 465     HIS A    30
REMARK 465     HIS A    31
REMARK 465     HIS A    32
REMARK 465     GLY A    33
REMARK 465     SER A    34
REMARK 465     ALA A    35
REMARK 465     PRO A    36
REMARK 465     ALA A    37
REMARK 465     GLN A    38
REMARK 465     ALA A    39
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     SER A 169    OG
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   O    HOH A   524     O    HOH A   671              1.68
REMARK 500   O    HOH A   641     O    HOH A   668              1.70
REMARK 500   O    HOH A   502     O    HOH A   522              1.78
REMARK 500   OD1  ASP A   202     O    HOH A   501              1.93
REMARK 500   NH2  ARG A   182     O    HOH A   502              1.95
REMARK 500   O    HOH A   615     O    HOH A   684              1.99
REMARK 500   N    ALA A    40     O    HOH A   503              2.00
REMARK 500   O    HOH A   506     O    HOH A   540              2.03
REMARK 500   O    HOH A   501     O    HOH A   692              2.03
REMARK 500   O    HOH A   502     O    HOH A   683              2.05
REMARK 500   OG   SER A   180     OD1  ASP A   202              2.08
REMARK 500   NH1  ARG A   182     O    HOH A   502              2.09
REMARK 500   O    HOH A   541     O    HOH A   599              2.10
REMARK 500   O    HOH A   596     O    HOH A   642              2.17
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS
REMARK 500
REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC
REMARK 500 SYMMETRY ARE IN CLOSE CONTACT.  AN ATOM LOCATED WITHIN 0.15
REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A
REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375
REMARK 500 INSTEAD OF REMARK 500.  ATOMS WITH NON-BLANK ALTERNATE
REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS.
REMARK 500
REMARK 500 DISTANCE CUTOFF:
REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS
REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI  SSYMOP   DISTANCE
REMARK 500   O    HOH A   678     O    HOH A   684     2554     1.96
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    ARG A  85   NE  -  CZ  -  NH1 ANGL. DEV. =  -4.7 DEGREES
REMARK 500    ARG A  85   NE  -  CZ  -  NH2 ANGL. DEV. =   5.0 DEGREES
REMARK 500    ARG A 155   NE  -  CZ  -  NH1 ANGL. DEV. =   4.0 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    THR A 100       -6.73     79.16
REMARK 500    SER A 169     -119.66     65.10
REMARK 500    THR A 192       56.73     34.51
REMARK 500    TRP A 200       55.76   -112.53
REMARK 500    TYR A 214       45.55   -107.23
REMARK 500    HIS A 223      -85.35   -121.98
REMARK 500    GLU A 271       26.74     49.51
REMARK 500
REMARK 500 REMARK: NULL
REMARK 620
REMARK 620 METAL COORDINATION
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA A 402  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 VAL A  63   O
REMARK 620 2 HOH A 625   O    98.3
REMARK 620 3 HOH A 690   O    83.6 170.9
REMARK 620 4 HOH A 597   O   100.0  98.3  90.1
REMARK 620 5 ASP A 149   O    26.4 117.5  67.4  79.4
REMARK 620 6 ALA A 150   O    18.8 112.9  71.1  85.9   7.7
REMARK 620 N                    1     2     3     4     5
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA A 403  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 ARG A  70   O
REMARK 620 2 ALA A  73   O    96.6
REMARK 620 3 PHE A  76   O   117.1  86.9
REMARK 620 4 HOH A 628   O   158.2  99.7  78.4
REMARK 620 5 HOH A 696   O    93.7  93.5 149.0  71.0
REMARK 620 6 HOH A 556   O   108.8 153.2  74.3  58.5  93.2
REMARK 620 N                    1     2     3     4     5
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              NA A 405  NA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 PRO A 193   O
REMARK 620 2 ALA A 218   O   108.6
REMARK 620 3 SER A 224   OG  112.7 138.7
REMARK 620 N                    1     2
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              NA A 406  NA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 ALA A 212   O
REMARK 620 2 GLU A 213   O    67.8
REMARK 620 3 HOH A 686   O   146.3  87.9
REMARK 620 N                    1     2
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA A 401  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 GLU A 213   OE1
REMARK 620 2 GLU A 213   OE2  52.3
REMARK 620 3 ASP A 243   OD1  81.9 133.4
REMARK 620 4 GLU A 292   OE1  97.5  88.2  89.8
REMARK 620 5 HOH A 622   O    85.0  83.2 103.3 167.0
REMARK 620 6 HOH A 654   O   157.7 146.9  76.6  76.7 105.6
REMARK 620 7 HOH A 661   O   125.1  73.1 153.0  85.8  82.3  76.5
REMARK 620 N                    1     2     3     4     5     6
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CA A 401
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CA A 402
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CA A 403
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue 9YL A 404
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue NA A 405
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue NA A 406
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue LAC A 407
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 3VIS   RELATED DB: PDB
REMARK 900 NATIVE PROTEIN
REMARK 900 RELATED ID: 3WYN   RELATED DB: PDB
REMARK 900 NATIVE PROTEIN WITH CALCIUM ION
DBREF  6AID A   35   300  UNP    F7IX06   F7IX06_9ACTN    35    300
SEQADV 6AID MET A   23  UNP  F7IX06              INITIATING METHIONINE
SEQADV 6AID ARG A   24  UNP  F7IX06              EXPRESSION TAG
SEQADV 6AID GLY A   25  UNP  F7IX06              EXPRESSION TAG
SEQADV 6AID SER A   26  UNP  F7IX06              EXPRESSION TAG
SEQADV 6AID HIS A   27  UNP  F7IX06              EXPRESSION TAG
SEQADV 6AID HIS A   28  UNP  F7IX06              EXPRESSION TAG
SEQADV 6AID HIS A   29  UNP  F7IX06              EXPRESSION TAG
SEQADV 6AID HIS A   30  UNP  F7IX06              EXPRESSION TAG
SEQADV 6AID HIS A   31  UNP  F7IX06              EXPRESSION TAG
SEQADV 6AID HIS A   32  UNP  F7IX06              EXPRESSION TAG
SEQADV 6AID GLY A   33  UNP  F7IX06              EXPRESSION TAG
SEQADV 6AID SER A   34  UNP  F7IX06              EXPRESSION TAG
SEQRES   1 A  278  MET ARG GLY SER HIS HIS HIS HIS HIS HIS GLY SER ALA
SEQRES   2 A  278  PRO ALA GLN ALA ALA ASN PRO TYR GLU ARG GLY PRO ASN
SEQRES   3 A  278  PRO THR GLU SER MET LEU GLU ALA ARG SER GLY PRO PHE
SEQRES   4 A  278  SER VAL SER GLU GLU ARG ALA SER ARG PHE GLY ALA ASP
SEQRES   5 A  278  GLY PHE GLY GLY GLY THR ILE TYR TYR PRO ARG GLU ASN
SEQRES   6 A  278  ASN THR TYR GLY ALA ILE ALA ILE SER PRO GLY TYR THR
SEQRES   7 A  278  GLY THR GLN SER SER ILE ALA TRP LEU GLY GLU ARG ILE
SEQRES   8 A  278  ALA SER HIS GLY PHE VAL VAL ILE ALA ILE ASP THR ASN
SEQRES   9 A  278  THR THR LEU ASP GLN PRO ASP SER ARG ALA ARG GLN LEU
SEQRES  10 A  278  ASN ALA ALA LEU ASP TYR MET LEU THR ASP ALA SER SER
SEQRES  11 A  278  ALA VAL ARG ASN ARG ILE ASP ALA SER ARG LEU ALA VAL
SEQRES  12 A  278  MET GLY HIS SER MET GLY GLY GLY GLY THR LEU ARG LEU
SEQRES  13 A  278  ALA SER GLN ARG PRO ASP LEU LYS ALA ALA ILE PRO LEU
SEQRES  14 A  278  THR PRO TRP HIS LEU ASN LYS SER TRP ARG ASP ILE THR
SEQRES  15 A  278  VAL PRO THR LEU ILE ILE GLY ALA GLU TYR ASP THR ILE
SEQRES  16 A  278  ALA SER VAL THR LEU HIS SER LYS PRO PHE TYR ASN SER
SEQRES  17 A  278  ILE PRO SER PRO THR ASP LYS ALA TYR LEU GLU LEU ASP
SEQRES  18 A  278  GLY ALA SER HIS PHE ALA PRO ASN ILE THR ASN LYS THR
SEQRES  19 A  278  ILE GLY MET TYR SER VAL ALA TRP LEU LYS ARG PHE VAL
SEQRES  20 A  278  ASP GLU ASP THR ARG TYR THR GLN PHE LEU CYS PRO GLY
SEQRES  21 A  278  PRO ARG THR GLY LEU LEU SER ASP VAL GLU GLU TYR ARG
SEQRES  22 A  278  SER THR CYS PRO PHE
HET     CA  A 401       1
HET     CA  A 402       1
HET     CA  A 403       1
HET    9YL  A 404       8
HET     NA  A 405       1
HET     NA  A 406       1
HET    LAC  A 407       6
HETNAM      CA CALCIUM ION
HETNAM     9YL ETHYL (2R)-2-OXIDANYLPROPANOATE
HETNAM      NA SODIUM ION
HETNAM     LAC LACTIC ACID
HETSYN     9YL ETHYL LACTATE
FORMUL   2   CA    3(CA 2+)
FORMUL   5  9YL    C5 H10 O3
FORMUL   6   NA    2(NA 1+)
FORMUL   8  LAC    C3 H6 O3
FORMUL   9  HOH   *222(H2 O)
HELIX    1 AA1 THR A   50  ALA A   56  1                                   7
HELIX    2 AA2 SER A   69  ALA A   73  5                                   5
HELIX    3 AA3 THR A  102  SER A  105  5                                   4
HELIX    4 AA4 ILE A  106  SER A  115  1                                  10
HELIX    5 AA5 GLN A  131  ASP A  149  1                                  19
HELIX    6 AA6 SER A  151  ASN A  156  1                                   6
HELIX    7 AA7 SER A  169  ARG A  182  1                                  14
HELIX    8 AA8 HIS A  223  ILE A  231  1                                   9
HELIX    9 AA9 PHE A  248  ILE A  252  5                                   5
HELIX   10 AB1 ASN A  254  ASP A  270  1                                  17
HELIX   11 AB2 ASP A  272  ARG A  274  5                                   3
HELIX   12 AB3 TYR A  275  CYS A  280  1                                   6
SHEET    1 AA1 6 VAL A  63  ALA A  68  0
SHEET    2 AA1 6 GLY A  79  PRO A  84 -1  O  ILE A  81   N  GLU A  66
SHEET    3 AA1 6 VAL A 119  ILE A 123 -1  O  VAL A 120   N  TYR A  82
SHEET    4 AA1 6 TYR A  90  SER A  96  1  N  ILE A  93   O  VAL A 119
SHEET    5 AA1 6 ILE A 158  HIS A 168  1  O  ASP A 159   N  TYR A  90
SHEET    6 AA1 6 ALA A 187  LEU A 191  1  O  LEU A 191   N  GLY A 167
SHEET    1 AA2 3 THR A 207  ALA A 212  0
SHEET    2 AA2 3 LYS A 237  LEU A 242  1  O  LEU A 242   N  GLY A 211
SHEET    3 AA2 3 VAL A 291  SER A 296 -1  O  GLU A 293   N  GLU A 241
SSBOND   1 CYS A  280    CYS A  298                          1555   1555  2.05
LINK         O   VAL A  63                CA    CA A 402     1555   1555  2.38
LINK         O   ARG A  70                CA    CA A 403     1555   1555  2.38
LINK         O   ALA A  73                CA    CA A 403     1555   1555  2.30
LINK         O   PHE A  76                CA    CA A 403     1555   1555  2.34
LINK         O   PRO A 193                NA    NA A 405     1555   1555  2.81
LINK         O   ALA A 212                NA    NA A 406     1555   1555  2.93
LINK         O   GLU A 213                NA    NA A 406     1555   1555  3.10
LINK         OE1 GLU A 213                CA    CA A 401     1555   1555  2.44
LINK         OE2 GLU A 213                CA    CA A 401     1555   1555  2.56
LINK         O   ALA A 218                NA    NA A 405     1555   1555  2.73
LINK         OG  SER A 224                NA    NA A 405     1555   1555  2.72
LINK         OD1 ASP A 243                CA    CA A 401     1555   1555  2.35
LINK         OE1 GLU A 292                CA    CA A 401     1555   1555  2.39
LINK        CA    CA A 401                 O   HOH A 622     1555   1555  2.30
LINK        CA    CA A 401                 O   HOH A 654     1555   1555  2.38
LINK        CA    CA A 401                 O   HOH A 661     1555   1555  2.39
LINK        CA    CA A 402                 O   HOH A 625     1555   1555  2.38
LINK        CA    CA A 402                 O   HOH A 690     1555   1555  2.36
LINK        CA    CA A 402                 O   HOH A 597     1555   1555  2.31
LINK        CA    CA A 403                 O   HOH A 628     1555   1555  2.68
LINK        CA    CA A 403                 O   HOH A 696     1555   1555  2.25
LINK        CA    CA A 403                 O   HOH A 556     1555   1555  2.57
LINK        NA    NA A 406                 O   HOH A 686     1555   1555  3.02
LINK         O   ASP A 149                CA    CA A 402     1555   4545  2.41
LINK         O   ALA A 150                CA    CA A 402     1555   4545  2.57
CISPEP   1 SER A  233    PRO A  234          0        10.31
CISPEP   2 CYS A  280    PRO A  281          0         5.34
CISPEP   3 CYS A  298    PRO A  299          0         9.75
SITE     1 AC1  6 GLU A 213  ASP A 243  GLU A 292  HOH A 622
SITE     2 AC1  6 HOH A 654  HOH A 661
SITE     1 AC2  6 VAL A  63  ASP A 149  ALA A 150  HOH A 597
SITE     2 AC2  6 HOH A 625  HOH A 690
SITE     1 AC3  6 ARG A  70  ALA A  73  PHE A  76  HOH A 556
SITE     2 AC3  6 HOH A 628  HOH A 696
SITE     1 AC4  9 GLY A  98  TYR A  99  SER A 169  SER A 233
SITE     2 AC4  9 HIS A 247  PHE A 248  LAC A 407  HOH A 550
SITE     3 AC4  9 HOH A 593
SITE     1 AC5  4 PRO A 193  ALA A 218  HIS A 223  SER A 224
SITE     1 AC6  6 ALA A 212  GLU A 213  ASP A 215  SER A 219
SITE     2 AC6  6 VAL A 220  HOH A 686
SITE     1 AC7  6 TYR A  99  MET A 170  TRP A 194  ILE A 217
SITE     2 AC7  6 9YL A 404  HOH A 550
CRYST1   42.265   68.860   78.594  90.00  90.00  90.00 P 21 21 21    4
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.023660  0.000000  0.000000        0.00000
SCALE2      0.000000  0.014522  0.000000        0.00000
SCALE3      0.000000  0.000000  0.012724        0.00000
TER    2010      PHE A 300
MASTER      591    0    7   12    9    0   14    6 2250    1   46   22
END