longtext: 6azc-pdb

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HEADER    HYDROLASE                               11-SEP-17   6AZC
TITLE     CRYSTAL STRUCTURE OF PHYSCOMITRELLA PATENS KAI2-LIKE E S166A
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: PP-KAI2-LIKE E;
COMPND   3 CHAIN: A, B;
COMPND   4 EC: 3.-.-.-;
COMPND   5 ENGINEERED: YES;
COMPND   6 MUTATION: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: PHYSCOMITRELLA PATENS SUBSP. PATENS;
SOURCE   3 ORGANISM_COMMON: MOSS;
SOURCE   4 ORGANISM_TAXID: 3218;
SOURCE   5 GENE: PHYPADRAFT_215526;
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3);
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 469008;
SOURCE   8 EXPRESSION_SYSTEM_STRAIN: BL21(DE3);
SOURCE   9 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;
SOURCE  10 EXPRESSION_SYSTEM_PLASMID: PGEX4T3
KEYWDS    ALPHA/BETA HYDROLASE, STRIGOLACTONE BINDING, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    M.BURGER,H.J.LEE,J.CHORY
REVDAT   1   06-FEB-19 6AZC    0
JRNL        AUTH   M.BURGER,K.MASHIGUCHI,H.J.LEE,M.NAKANO,K.TAKEMOTO,Y.SETO,
JRNL        AUTH 2 S.YAMAGUCHI,J.CHORY
JRNL        TITL   STRUCTURAL BASIS OF KARRIKIN AND NON-NATURAL STRIGOLACTONE
JRNL        TITL 2 PERCEPTION IN PHYSCOMITRELLA PATENS.
JRNL        REF    CELL REP                      V.  26   855 2019
JRNL        REFN                   ESSN 2211-1247
JRNL        PMID   30673608
JRNL        DOI    10.1016/J.CELREP.2019.01.003
REMARK   2
REMARK   2 RESOLUTION.    2.00 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : NULL
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.00
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 46.89
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 5.139
REMARK   3   COMPLETENESS FOR RANGE        (%) : 98.7
REMARK   3   NUMBER OF REFLECTIONS             : 34314
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.263
REMARK   3   R VALUE            (WORKING SET) : 0.220
REMARK   3   FREE R VALUE                     : 0.253
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.150
REMARK   3   FREE R VALUE TEST SET COUNT      : 1767
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 21.1134 -  4.5649    0.94     2768   149  0.2078 0.2462
REMARK   3     2  4.5649 -  3.6293    0.95     2751   145  0.1889 0.2450
REMARK   3     3  3.6293 -  3.1723    0.94     2736   151  0.2251 0.2483
REMARK   3     4  3.1723 -  2.8830    0.94     2715   150  0.2445 0.3091
REMARK   3     5  2.8830 -  2.6768    0.94     2728   140  0.2811 0.2622
REMARK   3     6  2.6768 -  2.5192    0.94     2715   150  0.2867 0.3278
REMARK   3     7  2.5192 -  2.3933    0.94     2714   138  0.2959 0.3400
REMARK   3     8  2.3933 -  2.2892    0.94     2682   140  0.3043 0.3592
REMARK   3     9  2.2892 -  2.2012    0.94     2715   133  0.3147 0.3532
REMARK   3    10  2.2012 -  2.1253    0.94     2706   145  0.3123 0.3617
REMARK   3    11  2.1253 -  2.0589    0.93     2697   141  0.3334 0.3599
REMARK   3    12  2.0589 -  2.0001    0.93     2639   138  0.3522 0.3800
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : NULL
REMARK   3   SOLVENT RADIUS     : 1.11
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : NULL
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 36.791
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 17.36
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :  0.003           4184
REMARK   3   ANGLE     :  0.591           5697
REMARK   3   CHIRALITY :  0.047            655
REMARK   3   PLANARITY :  0.004            735
REMARK   3   DIHEDRAL  :  2.201           2932
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : 1
REMARK   3   NCS GROUP : 1
REMARK   3    NCS OPERATOR : 1
REMARK   3     REFERENCE SELECTION: (CHAIN 'A' AND (RESID 6 THROUGH 100 OR
REMARK   3                          RESID 102 THROUGH 268))
REMARK   3     SELECTION          : (CHAIN 'B' AND (RESID 6 THROUGH 100 OR
REMARK   3                          RESID 102 THROUGH 268))
REMARK   3     ATOM PAIRS NUMBER  : NULL
REMARK   3     RMSD               : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 6AZC COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 11-SEP-17.
REMARK 100 THE DEPOSITION ID IS D_1000229842.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 17-AUG-17
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 8.5
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : ALS
REMARK 200  BEAMLINE                       : 8.2.1
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.000
REMARK 200  MONOCHROMATOR                  : DOUBLE CRYSTAL SI(111)
REMARK 200  OPTICS                         : MIRRORS
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 315R
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200  DATA SCALING SOFTWARE          : XSCALE
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 35204
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.000
REMARK 200  RESOLUTION RANGE LOW       (A) : 46.900
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 98.7
REMARK 200  DATA REDUNDANCY                : 3.700
REMARK 200  R MERGE                    (I) : 0.07743
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 11.5200
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.00
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.07
REMARK 200  COMPLETENESS FOR SHELL     (%) : 97.7
REMARK 200  DATA REDUNDANCY IN SHELL       : 3.80
REMARK 200  R MERGE FOR SHELL          (I) : 0.13200
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 8.120
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: PDB ENTRY 6AZB
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 43.97
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.20
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.1 M TRIS, PH 8.5, 30% PEG8000, VAPOR
REMARK 280  DIFFUSION, HANGING DROP, TEMPERATURE 298K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000       60.91050
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     GLY A    -1
REMARK 465     PRO A     0
REMARK 465     MET A     1
REMARK 465     GLU A     2
REMARK 465     GLU A     3
REMARK 465     PRO A     4
REMARK 465     SER A     5
REMARK 465     SER A   269
REMARK 465     LEU A   270
REMARK 465     GLY B    -1
REMARK 465     PRO B     0
REMARK 465     MET B     1
REMARK 465     GLU B     2
REMARK 465     GLU B     3
REMARK 465     PRO B     4
REMARK 465     SER B     5
REMARK 465     SER B   269
REMARK 465     LEU B   270
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   O    GLY A    27     O    HOH A   301              1.81
REMARK 500   O    HOH A   333     O    HOH B   371              1.91
REMARK 500   O    LEU B   214     O    HOH B   301              1.97
REMARK 500   NH1  ARG A   130     O    HOH A   302              1.99
REMARK 500   O    HOH A   303     O    HOH A   333              1.99
REMARK 500   ND1  HIS A    26     O    HOH A   301              2.00
REMARK 500   O    ARG A    68     O    HOH A   303              2.07
REMARK 500   O    LYS B   116     O    HOH B   302              2.07
REMARK 500   O    LEU A     6     O    HOH A   304              2.08
REMARK 500   O    HOH A   376     O    HOH A   382              2.10
REMARK 500   N    SER A   190     O    HOH A   305              2.11
REMARK 500   O    THR B    71     O    HOH B   303              2.13
REMARK 500   N    GLY B    57     O    HOH B   304              2.14
REMARK 500   O    LEU B     6     O    HOH B   305              2.15
REMARK 500   O    HOH B   321     O    HOH B   351              2.16
REMARK 500   OD1  ASP B   228     O    HOH B   306              2.16
REMARK 500   O    PHE B    66     O    HOH B   307              2.16
REMARK 500   O    LEU A   105     O    HOH A   306              2.18
REMARK 500   O    HOH A   325     O    HOH A   381              2.18
REMARK 500   OD1  ASP A    44     O    HOH A   307              2.19
REMARK 500   O    ASP A   186     O    HOH A   305              2.19
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS
REMARK 500
REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC
REMARK 500 SYMMETRY ARE IN CLOSE CONTACT.  AN ATOM LOCATED WITHIN 0.15
REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A
REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375
REMARK 500 INSTEAD OF REMARK 500.  ATOMS WITH NON-BLANK ALTERNATE
REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS.
REMARK 500
REMARK 500 DISTANCE CUTOFF:
REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS
REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI  SSYMOP   DISTANCE
REMARK 500   O    HOH A   348     O    HOH A   355     1554     2.19
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    LEU A   7      -61.73     60.02
REMARK 500    THR A  30     -159.09   -120.56
REMARK 500    PRO A  61       51.35   -107.73
REMARK 500    PHE A  63       74.72   -112.04
REMARK 500    SER A  97     -120.93     57.47
REMARK 500    ALA A 166     -171.63     59.87
REMARK 500    LEU B   7      -60.75     60.76
REMARK 500    THR B  30     -160.47   -120.07
REMARK 500    SER B  97     -123.80     59.19
REMARK 500    ALA B 166     -177.82     59.65
REMARK 500
REMARK 500 REMARK: NULL
DBREF  6AZC A    1   270  UNP    A9ST85   A9ST85_PHYPA     1    270
DBREF  6AZC B    1   270  UNP    A9ST85   A9ST85_PHYPA     1    270
SEQADV 6AZC GLY A   -1  UNP  A9ST85              CLONING ARTIFACT
SEQADV 6AZC PRO A    0  UNP  A9ST85              CLONING ARTIFACT
SEQADV 6AZC ALA A  166  UNP  A9ST85    SER   166 ENGINEERED MUTATION
SEQADV 6AZC GLY B   -1  UNP  A9ST85              CLONING ARTIFACT
SEQADV 6AZC PRO B    0  UNP  A9ST85              CLONING ARTIFACT
SEQADV 6AZC ALA B  166  UNP  A9ST85    SER   166 ENGINEERED MUTATION
SEQRES   1 A  272  GLY PRO MET GLU GLU PRO SER LEU LEU ASP ALA HIS ASN
SEQRES   2 A  272  VAL ARG VAL VAL GLY MET GLY SER GLU LEU VAL VAL LEU
SEQRES   3 A  272  GLY HIS GLY PHE GLY THR ASP GLN SER VAL TRP LYS HIS
SEQRES   4 A  272  VAL ILE PRO HIS LEU VAL ASP ASP TYR ARG VAL ILE LEU
SEQRES   5 A  272  PHE ASP ASN MET GLY ALA GLY THR THR ASP PRO GLU PHE
SEQRES   6 A  272  PHE SER PHE SER ARG TYR SER THR LEU HIS GLY TYR ALA
SEQRES   7 A  272  ASP ASP LEU LEU SER ILE LEU GLU GLU LEU GLU VAL GLU
SEQRES   8 A  272  SER CYS ILE TYR VAL GLY HIS SER VAL ALA GLY MET VAL
SEQRES   9 A  272  GLY CYS LEU ALA SER LEU GLU ARG PRO GLU ILE PHE THR
SEQRES  10 A  272  LYS ILE ILE THR LEU SER ALA SER PRO ARG TYR LEU ASN
SEQRES  11 A  272  ASP ARG ASP TYR PHE GLY GLY PHE GLU GLN ASP ASP LEU
SEQRES  12 A  272  ASN GLN LEU PHE GLU ALA MET GLN SER ASN PHE LYS ALA
SEQRES  13 A  272  TRP VAL SER GLY PHE ALA PRO LEU ALA VAL GLY ALA ASP
SEQRES  14 A  272  ILE ASP SER MET ALA VAL GLN GLU PHE GLY ARG THR LEU
SEQRES  15 A  272  PHE ASN ILE ARG PRO ASP ILE ALA PHE SER VAL ALA LYS
SEQRES  16 A  272  THR ILE PHE GLN SER ASP LEU ARG ILE MET LEU PRO LYS
SEQRES  17 A  272  VAL THR VAL PRO CYS HIS ILE LEU GLN SER SER LYS ASP
SEQRES  18 A  272  LEU ALA VAL PRO LEU VAL VAL ALA ASP TYR LEU HIS HIS
SEQRES  19 A  272  ALA LEU GLY GLY PRO THR ILE VAL GLU VAL LEU PRO THR
SEQRES  20 A  272  GLU GLY HIS LEU PRO GLN LEU SER SER PRO ASP ILE ILE
SEQRES  21 A  272  ILE PRO VAL LEU LYS ARG HIS LEU ALA GLY SER LEU
SEQRES   1 B  272  GLY PRO MET GLU GLU PRO SER LEU LEU ASP ALA HIS ASN
SEQRES   2 B  272  VAL ARG VAL VAL GLY MET GLY SER GLU LEU VAL VAL LEU
SEQRES   3 B  272  GLY HIS GLY PHE GLY THR ASP GLN SER VAL TRP LYS HIS
SEQRES   4 B  272  VAL ILE PRO HIS LEU VAL ASP ASP TYR ARG VAL ILE LEU
SEQRES   5 B  272  PHE ASP ASN MET GLY ALA GLY THR THR ASP PRO GLU PHE
SEQRES   6 B  272  PHE SER PHE SER ARG TYR SER THR LEU HIS GLY TYR ALA
SEQRES   7 B  272  ASP ASP LEU LEU SER ILE LEU GLU GLU LEU GLU VAL GLU
SEQRES   8 B  272  SER CYS ILE TYR VAL GLY HIS SER VAL ALA GLY MET VAL
SEQRES   9 B  272  GLY CYS LEU ALA SER LEU GLU ARG PRO GLU ILE PHE THR
SEQRES  10 B  272  LYS ILE ILE THR LEU SER ALA SER PRO ARG TYR LEU ASN
SEQRES  11 B  272  ASP ARG ASP TYR PHE GLY GLY PHE GLU GLN ASP ASP LEU
SEQRES  12 B  272  ASN GLN LEU PHE GLU ALA MET GLN SER ASN PHE LYS ALA
SEQRES  13 B  272  TRP VAL SER GLY PHE ALA PRO LEU ALA VAL GLY ALA ASP
SEQRES  14 B  272  ILE ASP SER MET ALA VAL GLN GLU PHE GLY ARG THR LEU
SEQRES  15 B  272  PHE ASN ILE ARG PRO ASP ILE ALA PHE SER VAL ALA LYS
SEQRES  16 B  272  THR ILE PHE GLN SER ASP LEU ARG ILE MET LEU PRO LYS
SEQRES  17 B  272  VAL THR VAL PRO CYS HIS ILE LEU GLN SER SER LYS ASP
SEQRES  18 B  272  LEU ALA VAL PRO LEU VAL VAL ALA ASP TYR LEU HIS HIS
SEQRES  19 B  272  ALA LEU GLY GLY PRO THR ILE VAL GLU VAL LEU PRO THR
SEQRES  20 B  272  GLU GLY HIS LEU PRO GLN LEU SER SER PRO ASP ILE ILE
SEQRES  21 B  272  ILE PRO VAL LEU LYS ARG HIS LEU ALA GLY SER LEU
FORMUL   3  HOH   *160(H2 O)
HELIX    1 AA1 ASP A   31  LYS A   36  5                                   6
HELIX    2 AA2 VAL A   38  LEU A   42  5                                   5
HELIX    3 AA3 LEU A   72  LEU A   86  1                                  15
HELIX    4 AA4 SER A   97  ARG A  110  1                                  14
HELIX    5 AA5 GLU A  137  ASN A  151  1                                  15
HELIX    6 AA6 ASN A  151  GLY A  165  1                                  15
HELIX    7 AA7 SER A  170  ASN A  182  1                                  13
HELIX    8 AA8 ARG A  184  GLN A  197  1                                  14
HELIX    9 AA9 MET A  203  VAL A  207  5                                   5
HELIX   10 AB1 PRO A  223  LEU A  234  1                                  12
HELIX   11 AB2 LEU A  249  SER A  254  1                                   6
HELIX   12 AB3 SER A  254  GLY A  268  1                                  15
HELIX   13 AB4 ASP B   31  LYS B   36  5                                   6
HELIX   14 AB5 VAL B   38  LEU B   42  5                                   5
HELIX   15 AB6 LEU B   72  LEU B   86  1                                  15
HELIX   16 AB7 SER B   97  ARG B  110  1                                  14
HELIX   17 AB8 GLU B  137  ASN B  151  1                                  15
HELIX   18 AB9 ASN B  151  GLY B  165  1                                  15
HELIX   19 AC1 SER B  170  ASN B  182  1                                  13
HELIX   20 AC2 ARG B  184  GLN B  197  1                                  14
HELIX   21 AC3 MET B  203  VAL B  207  5                                   5
HELIX   22 AC4 LEU B  224  LEU B  234  1                                  11
HELIX   23 AC5 LEU B  249  SER B  254  1                                   6
HELIX   24 AC6 SER B  254  GLY B  268  1                                  15
SHEET    1 AA1 7 ARG A  13  GLY A  16  0
SHEET    2 AA1 7 TYR A  46  LEU A  50 -1  O  VAL A  48   N  VAL A  15
SHEET    3 AA1 7 GLU A  20  GLY A  25  1  N  GLU A  20   O  ARG A  47
SHEET    4 AA1 7 CYS A  91  HIS A  96  1  O  VAL A  94   N  VAL A  23
SHEET    5 AA1 7 PHE A 114  LEU A 120  1  O  ILE A 118   N  GLY A  95
SHEET    6 AA1 7 CYS A 211  LYS A 218  1  O  LEU A 214   N  THR A 119
SHEET    7 AA1 7 THR A 238  GLU A 246  1  O  ILE A 239   N  ILE A 213
SHEET    1 AA2 7 ARG B  13  GLY B  16  0
SHEET    2 AA2 7 TYR B  46  LEU B  50 -1  O  LEU B  50   N  ARG B  13
SHEET    3 AA2 7 GLU B  20  GLY B  25  1  N  GLU B  20   O  ARG B  47
SHEET    4 AA2 7 CYS B  91  HIS B  96  1  O  ILE B  92   N  VAL B  23
SHEET    5 AA2 7 PHE B 114  LEU B 120  1  O  ILE B 118   N  GLY B  95
SHEET    6 AA2 7 CYS B 211  LYS B 218  1  O  LEU B 214   N  THR B 119
SHEET    7 AA2 7 THR B 238  GLU B 246  1  O  LEU B 243   N  GLN B 215
CRYST1   45.932  121.821   46.909  90.00  91.54  90.00 P 1 21 1      4
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.021771  0.000000  0.000585        0.00000
SCALE2      0.000000  0.008209  0.000000        0.00000
SCALE3      0.000000  0.000000  0.021326        0.00000
TER    2040      GLY A 268
TER    4085      GLY B 268
MASTER      306    0    0   24   14    0    0    6 4238    2    0   42
END