longtext: 6azd-pdb

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HEADER    HYDROLASE                               11-SEP-17   6AZD
TITLE     CRYSTAL STRUCTURE OF PHYSCOMITRELLA PATENS KAI2-LIKE H
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: PPKAI2-LIKE H;
COMPND   3 CHAIN: A;
COMPND   4 EC: 3.-.-.-;
COMPND   5 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: PHYSCOMITRELLA PATENS SUBSP. PATENS;
SOURCE   3 ORGANISM_COMMON: MOSS;
SOURCE   4 ORGANISM_TAXID: 3218;
SOURCE   5 GENE: PHYPADRAFT_184560;
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3);
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 469008;
SOURCE   8 EXPRESSION_SYSTEM_STRAIN: BL21(DE3);
SOURCE   9 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;
SOURCE  10 EXPRESSION_SYSTEM_PLASMID: PGEX4T3
KEYWDS    ALPHA/BETA HYDROLASE, STRIGOLACTONE BINDING, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    M.BURGER,H.J.LEE,J.CHORY
REVDAT   1   06-FEB-19 6AZD    0
JRNL        AUTH   M.BURGER,K.MASHIGUCHI,H.J.LEE,M.NAKANO,K.TAKEMOTO,Y.SETO,
JRNL        AUTH 2 S.YAMAGUCHI,J.CHORY
JRNL        TITL   STRUCTURAL BASIS OF KARRIKIN AND NON-NATURAL STRIGOLACTONE
JRNL        TITL 2 PERCEPTION IN PHYSCOMITRELLA PATENS.
JRNL        REF    CELL REP                      V.  26   855 2019
JRNL        REFN                   ESSN 2211-1247
JRNL        PMID   30673608
JRNL        DOI    10.1016/J.CELREP.2019.01.003
REMARK   2
REMARK   2 RESOLUTION.    1.97 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : NULL
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.97
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 37.02
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.349
REMARK   3   COMPLETENESS FOR RANGE        (%) : 98.3
REMARK   3   NUMBER OF REFLECTIONS             : 18741
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.210
REMARK   3   R VALUE            (WORKING SET) : 0.208
REMARK   3   FREE R VALUE                     : 0.243
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.962
REMARK   3   FREE R VALUE TEST SET COUNT      : 930
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 37.0247 -  3.7675    0.97     2576   121  0.1697 0.1662
REMARK   3     2  3.7675 -  2.9908    0.98     2534   161  0.1807 0.2260
REMARK   3     3  2.9908 -  2.6129    0.99     2543   128  0.2116 0.2280
REMARK   3     4  2.6129 -  2.3740    0.99     2581   126  0.2227 0.2645
REMARK   3     5  2.3740 -  2.2039    0.98     2552   108  0.2306 0.3241
REMARK   3     6  2.2039 -  2.0740    0.99     2538   130  0.2429 0.2748
REMARK   3     7  2.0740 -  1.9701    0.98     2487   156  0.2807 0.3336
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : NULL
REMARK   3   SOLVENT RADIUS     : 1.11
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.277
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 24.133
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 14.90
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :  0.003           2108
REMARK   3   ANGLE     :  0.605           2872
REMARK   3   CHIRALITY :  0.044            334
REMARK   3   PLANARITY :  0.003            371
REMARK   3   DIHEDRAL  :  2.661           1247
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 6AZD COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 11-SEP-17.
REMARK 100 THE DEPOSITION ID IS D_1000229832.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 08-AUG-16
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 6.5
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : ALS
REMARK 200  BEAMLINE                       : 8.2.1
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.000
REMARK 200  MONOCHROMATOR                  : DOUBLE CRYSTAL SI(111)
REMARK 200  OPTICS                         : MIRRORS
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 315R
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200  DATA SCALING SOFTWARE          : XSCALE
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 18745
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.970
REMARK 200  RESOLUTION RANGE LOW       (A) : 37.100
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 98.3
REMARK 200  DATA REDUNDANCY                : 3.500
REMARK 200  R MERGE                    (I) : 0.16740
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 8.1700
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.97
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.04
REMARK 200  COMPLETENESS FOR SHELL     (%) : 97.7
REMARK 200  DATA REDUNDANCY IN SHELL       : 3.40
REMARK 200  R MERGE FOR SHELL          (I) : 0.44490
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 3.850
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: PDB ENTRY 4JYP
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 45.75
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.27
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 1.8 M AMMONIUM SULFATE, 0.1 M MES 6.5,
REMARK 280  5% PEG400, PH 6.5, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE
REMARK 280  298K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000       26.32500
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 0 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 11000 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: 0.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     GLY A    -1
REMARK 465     PRO A     0
REMARK 465     MET A     1
REMARK 465     PRO A     2
REMARK 465     SER A   269
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     ASP A  64    CG   OD1  OD2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   OD1  ASP A   268     O    HOH A   301              2.09
REMARK 500   O    HOH A   335     O    HOH A   439              2.19
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS
REMARK 500
REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC
REMARK 500 SYMMETRY ARE IN CLOSE CONTACT.  AN ATOM LOCATED WITHIN 0.15
REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A
REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375
REMARK 500 INSTEAD OF REMARK 500.  ATOMS WITH NON-BLANK ALTERNATE
REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS.
REMARK 500
REMARK 500 DISTANCE CUTOFF:
REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS
REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI  SSYMOP   DISTANCE
REMARK 500   O    HOH A   399     O    HOH A   417     1565     2.18
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    THR A  30     -169.40   -116.99
REMARK 500    ASP A  64       63.25   -115.07
REMARK 500    SER A  98     -121.73     52.37
REMARK 500    ASN A 152       80.25   -154.55
REMARK 500    GLU A 172      -18.70   -147.27
REMARK 500    CYS A 255       59.24   -143.30
REMARK 500
REMARK 500 REMARK: NULL
DBREF  6AZD A    1   269  UNP    A9SG07   A9SG07_PHYPA     1    269
SEQADV 6AZD GLY A   -1  UNP  A9SG07              CLONING ARTIFACT
SEQADV 6AZD PRO A    0  UNP  A9SG07              CLONING ARTIFACT
SEQRES   1 A  271  GLY PRO MET PRO SER PRO LEU LEU SER THR HIS ASN VAL
SEQRES   2 A  271  THR VAL LEU GLY ASN ARG SER ASP PRO VAL VAL VAL LEU
SEQRES   3 A  271  GLY HIS GLY LEU GLY THR ASP GLN SER VAL TRP LYS TYR
SEQRES   4 A  271  THR VAL PRO SER LEU VAL ASN GLN ASN PHE GLN VAL VAL
SEQRES   5 A  271  LEU TYR ASP THR MET GLY ALA GLY SER THR GLU THR SER
SEQRES   6 A  271  ASP PHE ASN PHE LYS ARG TYR SER SER LEU GLN GLY HIS
SEQRES   7 A  271  VAL ASP ASP LEU LEU ALA ILE LEU ASP GLU LEU GLU ILE
SEQRES   8 A  271  GLU ASN CYS VAL TYR VAL GLY HIS SER MET SER GLY MET
SEQRES   9 A  271  ILE GLY VAL LEU ALA SER LEU GLU ARG PRO ASP LEU PHE
SEQRES  10 A  271  ARG LYS LEU ILE LEU LEU SER ALA SER PRO ARG TYR LEU
SEQRES  11 A  271  ASN ASP SER SER TYR TYR GLY GLY PHE GLU GLN GLU ASP
SEQRES  12 A  271  LEU ASP GLN LEU PHE SER SER MET ARG SER ASN PHE SER
SEQRES  13 A  271  ALA TRP VAL SER GLY PHE ALA THR ALA ALA VAL GLY THR
SEQRES  14 A  271  ASP ILE HIS ASP GLU ALA VAL GLN GLU PHE SER SER THR
SEQRES  15 A  271  PHE ILE SER MET ARG PRO ASP VAL ALA LEU ARG THR SER
SEQRES  16 A  271  GLN PHE VAL PHE GLN SER ASP PHE ARG SER ILE LEU SER
SEQRES  17 A  271  GLU VAL THR VAL PRO CYS HIS ILE VAL GLN SER ARG LYS
SEQRES  18 A  271  ASP ILE ALA VAL PRO ILE GLU VAL ALA GLU TYR LEU ARG
SEQRES  19 A  271  CYS ASN LEU GLY GLY TRP THR SER VAL ASP ILE LEU GLN
SEQRES  20 A  271  THR ASP GLY HIS LEU PRO GLN LEU SER CYS PRO GLU LEU
SEQRES  21 A  271  VAL VAL PRO VAL LEU LEU HIS CYS ILE ASP SER
FORMUL   2  HOH   *155(H2 O)
HELIX    1 AA1 SER A    3  HIS A    9  1                                   7
HELIX    2 AA2 ASP A   31  LYS A   36  5                                   6
HELIX    3 AA3 THR A   38  GLN A   45  1                                   8
HELIX    4 AA4 SER A   72  LEU A   87  1                                  16
HELIX    5 AA5 SER A   98  ARG A  111  1                                  14
HELIX    6 AA6 GLU A  138  ASN A  152  1                                  15
HELIX    7 AA7 ASN A  152  GLY A  166  1                                  15
HELIX    8 AA8 GLU A  172  SER A  183  1                                  12
HELIX    9 AA9 ARG A  185  GLN A  198  1                                  14
HELIX   10 AB1 PHE A  201  VAL A  208  5                                   8
HELIX   11 AB2 PRO A  224  LEU A  235  1                                  12
HELIX   12 AB3 LEU A  250  CYS A  255  1                                   6
HELIX   13 AB4 CYS A  255  ASP A  268  1                                  14
SHEET    1 AA1 7 THR A  12  LEU A  14  0
SHEET    2 AA1 7 GLN A  48  LEU A  51 -1  O  VAL A  49   N  LEU A  14
SHEET    3 AA1 7 VAL A  21  GLY A  25  1  N  VAL A  22   O  VAL A  50
SHEET    4 AA1 7 CYS A  92  HIS A  97  1  O  VAL A  95   N  VAL A  23
SHEET    5 AA1 7 PHE A 115  LEU A 121  1  O  LEU A 121   N  GLY A  96
SHEET    6 AA1 7 CYS A 212  LYS A 219  1  O  VAL A 215   N  LEU A 120
SHEET    7 AA1 7 THR A 239  ASP A 247  1  O  SER A 240   N  ILE A 214
CRYST1   49.410   52.650   52.300  90.00  95.51  90.00 P 1 21 1      2
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.020239  0.000000  0.001952        0.00000
SCALE2      0.000000  0.018993  0.000000        0.00000
SCALE3      0.000000  0.000000  0.019209        0.00000
TER    2064      ASP A 268
MASTER      263    0    0   13    7    0    0    6 2218    1    0   21
END