longtext: 6ecf-pdb

content
HEADER    HYDROLASE                               07-AUG-18   6ECF
TITLE     VLM2 THIOESTERASE DOMAIN WITH GENETICALLY ENCODED 2,3-DIAMINOPROPIONIC
TITLE    2 ACID BOUND WITH A DODECADEPSIPEPTIDE, SPACE GROUP P1
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: VLM2;
COMPND   3 CHAIN: A, B, C, D, E, F;
COMPND   4 FRAGMENT: THIOESTERASE DOMAIN (UNP RESIDUES 2368-2655);
COMPND   5 EC: 3.1.2.-;
COMPND   6 ENGINEERED: YES;
COMPND   7 MOL_ID: 2;
COMPND   8 MOLECULE: DODECADEPSIPEPTIDE;
COMPND   9 CHAIN: G, I, H, K, J, L;
COMPND  10 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: STREPTOMYCES TSUSIMAENSIS;
SOURCE   3 ORGANISM_TAXID: 285482;
SOURCE   4 ATCC: 15141;
SOURCE   5 GENE: VLM2;
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3);
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 469008;
SOURCE   8 MOL_ID: 2;
SOURCE   9 SYNTHETIC: YES;
SOURCE  10 ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT;
SOURCE  11 ORGANISM_TAXID: 32630
KEYWDS    THIOESTERASE, THIOESTERASE DOMAIN, NRPS, NON-RIBOSOMAL PEPTIDE
KEYWDS   2 SYNTHETASE, NONRIBOSOMAL PEPTIDE SYNTHETASE, VALINOMYCIN, HYDROLASE,
KEYWDS   3 DEPSIPEPTIDE, UNNATURAL AMINO ACID, 2, 3-DIAMINOPROPIONIC ACID
EXPDTA    X-RAY DIFFRACTION
AUTHOR    D.A.ALONZO,N.HUGUENIN-DEZOT,G.W.HEBERLIG,M.MAHESH,D.P.NGUYEN,
AUTHOR   2 M.H.DORNAN,C.N.BODDY,J.W.CHIN,T.M.SCHMEING
REVDAT   1   12-DEC-18 6ECF    0
JRNL        AUTH   N.HUGUENIN-DEZOT,D.A.ALONZO,G.W.HEBERLIG,M.MAHESH,
JRNL        AUTH 2 D.P.NGUYEN,M.H.DORNAN,C.N.BODDY,T.M.SCHMEING,J.W.CHIN
JRNL        TITL   TRAPPING BIOSYNTHETIC ACYL-ENZYME INTERMEDIATES WITH ENCODED
JRNL        TITL 2 2,3--DIAMINOPROPIONIC ACID.
JRNL        REF    NATURE                                     2018
JRNL        REFN                   ESSN 1476-4687
JRNL        DOI    10.1038/S41586-018-0781-Z
REMARK   2
REMARK   2 RESOLUTION.    2.50 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX 1.13_2998
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : NULL
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.50
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 78.55
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 2.080
REMARK   3   COMPLETENESS FOR RANGE        (%) : 97.6
REMARK   3   NUMBER OF REFLECTIONS             : 53933
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.200
REMARK   3   R VALUE            (WORKING SET) : 0.197
REMARK   3   FREE R VALUE                     : 0.249
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.970
REMARK   3   FREE R VALUE TEST SET COUNT      : 2683
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 78.5900 -  6.6700    0.99     2726   158  0.1973 0.2635
REMARK   3     2  6.6700 -  5.2900    0.98     2657   174  0.2100 0.2673
REMARK   3     3  5.2900 -  4.6300    0.98     2724   152  0.1545 0.1973
REMARK   3     4  4.6300 -  4.2000    0.98     2675   183  0.1583 0.1937
REMARK   3     5  4.2000 -  3.9000    0.98     2698   119  0.1702 0.2437
REMARK   3     6  3.9000 -  3.6700    0.98     2675   155  0.1724 0.1859
REMARK   3     7  3.6700 -  3.4900    0.98     2731   114  0.1808 0.2172
REMARK   3     8  3.4900 -  3.3400    0.98     2732   130  0.1942 0.2898
REMARK   3     9  3.3400 -  3.2100    0.98     2687   126  0.2228 0.2660
REMARK   3    10  3.2100 -  3.1000    0.97     2748   106  0.2181 0.2770
REMARK   3    11  3.1000 -  3.0000    0.98     2706   121  0.2218 0.3061
REMARK   3    12  3.0000 -  2.9100    0.97     2692   169  0.2205 0.2845
REMARK   3    13  2.9100 -  2.8400    0.97     2611   166  0.2362 0.3061
REMARK   3    14  2.8400 -  2.7700    0.97     2754   120  0.2404 0.2983
REMARK   3    15  2.7700 -  2.7100    0.97     2739   126  0.2497 0.3445
REMARK   3    16  2.7100 -  2.6500    0.97     2588   135  0.2345 0.2903
REMARK   3    17  2.6500 -  2.5900    0.97     2735   143  0.2390 0.2635
REMARK   3    18  2.5900 -  2.5500    0.97     2711   127  0.2418 0.3044
REMARK   3    19  2.5500 -  2.5000    0.97     2661   159  0.2423 0.2992
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : NULL
REMARK   3   SOLVENT RADIUS     : 1.11
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.329
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 26.508
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 41.08
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 48.32
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :  0.002          11837
REMARK   3   ANGLE     :  0.558          16106
REMARK   3   CHIRALITY :  0.040           1817
REMARK   3   PLANARITY :  0.003           2110
REMARK   3   DIHEDRAL  : 11.355           6960
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 6ECF COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 08-AUG-18.
REMARK 100 THE DEPOSITION ID IS D_1000236075.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 03-DEC-17
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 8.0
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : CLSI
REMARK 200  BEAMLINE                       : 08ID-1
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : .9794
REMARK 200  MONOCHROMATOR                  : DOUBLE CRYSTAL SI(111)
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : PIXEL
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS PILATUS3 S 6M
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : DIALS
REMARK 200  DATA SCALING SOFTWARE          : AIMLESS
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 53945
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.500
REMARK 200  RESOLUTION RANGE LOW       (A) : 78.550
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 97.6
REMARK 200  DATA REDUNDANCY                : 1.700
REMARK 200  R MERGE                    (I) : 0.07100
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 4.1000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.50
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.58
REMARK 200  COMPLETENESS FOR SHELL     (%) : NULL
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL
REMARK 200  R MERGE FOR SHELL          (I) : NULL
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: PDB ENTRY 6ECB
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 40.31
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.06
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 1.4 M DL-MALIC ACID, 25 MM HEPES, PH
REMARK 280  8.0, 100 MM SODIUM CHLORIDE, 0.2 MM TCEP, VAPOR DIFFUSION,
REMARK 280  HANGING DROP, TEMPERATURE 295K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2, 3, 4, 5, 6
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, G
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B, I
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 3
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C, H
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 4
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: D, K
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 5
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: E, J
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 6
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: F, L
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A  2353
REMARK 465     HIS A  2354
REMARK 465     HIS A  2355
REMARK 465     HIS A  2356
REMARK 465     HIS A  2357
REMARK 465     HIS A  2358
REMARK 465     HIS A  2359
REMARK 465     HIS A  2360
REMARK 465     HIS A  2361
REMARK 465     GLU A  2362
REMARK 465     ASN A  2363
REMARK 465     LEU A  2364
REMARK 465     TYR A  2365
REMARK 465     PHE A  2366
REMARK 465     GLN A  2367
REMARK 465     GLY A  2368
REMARK 465     GLY A  2369
REMARK 465     SER A  2370
REMARK 465     SER A  2371
REMARK 465     THR A  2372
REMARK 465     ALA A  2373
REMARK 465     GLY A  2374
REMARK 465     GLY A  2496
REMARK 465     ASP A  2497
REMARK 465     ILE A  2498
REMARK 465     PRO A  2499
REMARK 465     VAL A  2500
REMARK 465     ALA A  2501
REMARK 465     ASP A  2502
REMARK 465     ALA A  2503
REMARK 465     ASP A  2504
REMARK 465     LEU A  2505
REMARK 465     GLY A  2518
REMARK 465     ILE A  2519
REMARK 465     GLY A  2520
REMARK 465     GLY A  2521
REMARK 465     MET A  2522
REMARK 465     LEU A  2523
REMARK 465     ASP A  2524
REMARK 465     GLN A  2525
REMARK 465     ASP A  2526
REMARK 465     ARG A  2527
REMARK 465     ASP A  2528
REMARK 465     ALA A  2529
REMARK 465     LEU A  2530
REMARK 465     SER A  2649
REMARK 465     ASP A  2650
REMARK 465     ASP A  2651
REMARK 465     GLY A  2652
REMARK 465     PRO A  2653
REMARK 465     ARG A  2654
REMARK 465     GLY A  2655
REMARK 465     MET B  2353
REMARK 465     HIS B  2354
REMARK 465     HIS B  2355
REMARK 465     HIS B  2356
REMARK 465     HIS B  2357
REMARK 465     HIS B  2358
REMARK 465     HIS B  2359
REMARK 465     HIS B  2360
REMARK 465     HIS B  2361
REMARK 465     GLU B  2362
REMARK 465     ASN B  2363
REMARK 465     LEU B  2364
REMARK 465     TYR B  2365
REMARK 465     PHE B  2366
REMARK 465     GLN B  2367
REMARK 465     GLY B  2368
REMARK 465     GLY B  2369
REMARK 465     SER B  2370
REMARK 465     SER B  2371
REMARK 465     THR B  2372
REMARK 465     ALA B  2373
REMARK 465     GLY B  2374
REMARK 465     ASP B  2375
REMARK 465     ASP B  2497
REMARK 465     ILE B  2498
REMARK 465     PRO B  2499
REMARK 465     VAL B  2500
REMARK 465     ALA B  2501
REMARK 465     ASP B  2502
REMARK 465     ALA B  2503
REMARK 465     ASP B  2504
REMARK 465     LEU B  2505
REMARK 465     ILE B  2519
REMARK 465     GLY B  2520
REMARK 465     GLY B  2521
REMARK 465     MET B  2522
REMARK 465     LEU B  2523
REMARK 465     ASP B  2524
REMARK 465     GLN B  2525
REMARK 465     ASP B  2526
REMARK 465     ARG B  2527
REMARK 465     ASP B  2528
REMARK 465     ALA B  2529
REMARK 465     LEU B  2530
REMARK 465     LYS B  2531
REMARK 465     ASP B  2650
REMARK 465     ASP B  2651
REMARK 465     GLY B  2652
REMARK 465     PRO B  2653
REMARK 465     ARG B  2654
REMARK 465     GLY B  2655
REMARK 465     MET C  2353
REMARK 465     HIS C  2354
REMARK 465     HIS C  2355
REMARK 465     HIS C  2356
REMARK 465     HIS C  2357
REMARK 465     HIS C  2358
REMARK 465     HIS C  2359
REMARK 465     HIS C  2360
REMARK 465     HIS C  2361
REMARK 465     GLU C  2362
REMARK 465     ASN C  2363
REMARK 465     LEU C  2364
REMARK 465     TYR C  2365
REMARK 465     PHE C  2366
REMARK 465     GLN C  2367
REMARK 465     GLY C  2368
REMARK 465     GLY C  2369
REMARK 465     SER C  2370
REMARK 465     SER C  2371
REMARK 465     THR C  2372
REMARK 465     ALA C  2373
REMARK 465     GLY C  2374
REMARK 465     ASP C  2375
REMARK 465     ILE C  2498
REMARK 465     PRO C  2499
REMARK 465     VAL C  2500
REMARK 465     ALA C  2501
REMARK 465     ASP C  2502
REMARK 465     ALA C  2503
REMARK 465     ASP C  2504
REMARK 465     LEU C  2505
REMARK 465     THR C  2506
REMARK 465     ILE C  2519
REMARK 465     GLY C  2520
REMARK 465     GLY C  2521
REMARK 465     MET C  2522
REMARK 465     LEU C  2523
REMARK 465     ASP C  2524
REMARK 465     GLN C  2525
REMARK 465     ASP C  2526
REMARK 465     ARG C  2527
REMARK 465     ASP C  2528
REMARK 465     ALA C  2529
REMARK 465     LEU C  2530
REMARK 465     SER C  2649
REMARK 465     ASP C  2650
REMARK 465     ASP C  2651
REMARK 465     GLY C  2652
REMARK 465     PRO C  2653
REMARK 465     ARG C  2654
REMARK 465     GLY C  2655
REMARK 465     MET D  2353
REMARK 465     HIS D  2354
REMARK 465     HIS D  2355
REMARK 465     HIS D  2356
REMARK 465     HIS D  2357
REMARK 465     HIS D  2358
REMARK 465     HIS D  2359
REMARK 465     HIS D  2360
REMARK 465     HIS D  2361
REMARK 465     GLU D  2362
REMARK 465     ASN D  2363
REMARK 465     LEU D  2364
REMARK 465     TYR D  2365
REMARK 465     PHE D  2366
REMARK 465     GLN D  2367
REMARK 465     GLY D  2368
REMARK 465     GLY D  2369
REMARK 465     SER D  2370
REMARK 465     SER D  2371
REMARK 465     THR D  2372
REMARK 465     ALA D  2373
REMARK 465     GLY D  2374
REMARK 465     ASP D  2375
REMARK 465     PRO D  2376
REMARK 465     VAL D  2500
REMARK 465     ALA D  2501
REMARK 465     ASP D  2502
REMARK 465     ALA D  2503
REMARK 465     ASP D  2504
REMARK 465     LEU D  2505
REMARK 465     PRO D  2648
REMARK 465     SER D  2649
REMARK 465     ASP D  2650
REMARK 465     ASP D  2651
REMARK 465     GLY D  2652
REMARK 465     PRO D  2653
REMARK 465     ARG D  2654
REMARK 465     GLY D  2655
REMARK 465     MET E  2353
REMARK 465     HIS E  2354
REMARK 465     HIS E  2355
REMARK 465     HIS E  2356
REMARK 465     HIS E  2357
REMARK 465     HIS E  2358
REMARK 465     HIS E  2359
REMARK 465     HIS E  2360
REMARK 465     HIS E  2361
REMARK 465     GLU E  2362
REMARK 465     ASN E  2363
REMARK 465     LEU E  2364
REMARK 465     TYR E  2365
REMARK 465     PHE E  2366
REMARK 465     GLN E  2367
REMARK 465     GLY E  2368
REMARK 465     GLY E  2369
REMARK 465     SER E  2370
REMARK 465     SER E  2371
REMARK 465     THR E  2372
REMARK 465     ALA E  2373
REMARK 465     GLY E  2374
REMARK 465     ASP E  2375
REMARK 465     PRO E  2376
REMARK 465     THR E  2377
REMARK 465     ALA E  2378
REMARK 465     PRO E  2499
REMARK 465     VAL E  2500
REMARK 465     ALA E  2501
REMARK 465     ASP E  2502
REMARK 465     ALA E  2503
REMARK 465     ASP E  2504
REMARK 465     LEU E  2505
REMARK 465     THR E  2506
REMARK 465     ALA E  2598
REMARK 465     ASP E  2650
REMARK 465     ASP E  2651
REMARK 465     GLY E  2652
REMARK 465     PRO E  2653
REMARK 465     ARG E  2654
REMARK 465     GLY E  2655
REMARK 465     MET F  2353
REMARK 465     HIS F  2354
REMARK 465     HIS F  2355
REMARK 465     HIS F  2356
REMARK 465     HIS F  2357
REMARK 465     HIS F  2358
REMARK 465     HIS F  2359
REMARK 465     HIS F  2360
REMARK 465     HIS F  2361
REMARK 465     GLU F  2362
REMARK 465     ASN F  2363
REMARK 465     LEU F  2364
REMARK 465     TYR F  2365
REMARK 465     PHE F  2366
REMARK 465     GLN F  2367
REMARK 465     GLY F  2368
REMARK 465     GLY F  2369
REMARK 465     SER F  2370
REMARK 465     SER F  2371
REMARK 465     THR F  2372
REMARK 465     ALA F  2373
REMARK 465     GLY F  2374
REMARK 465     ASP F  2375
REMARK 465     ASP F  2389
REMARK 465     GLY F  2390
REMARK 465     GLY F  2496
REMARK 465     ASP F  2497
REMARK 465     ILE F  2498
REMARK 465     PRO F  2499
REMARK 465     VAL F  2500
REMARK 465     ALA F  2501
REMARK 465     ASP F  2502
REMARK 465     ALA F  2503
REMARK 465     ASP F  2504
REMARK 465     LEU F  2505
REMARK 465     THR F  2506
REMARK 465     GLU F  2507
REMARK 465     PRO F  2648
REMARK 465     SER F  2649
REMARK 465     ASP F  2650
REMARK 465     ASP F  2651
REMARK 465     GLY F  2652
REMARK 465     PRO F  2653
REMARK 465     ARG F  2654
REMARK 465     GLY F  2655
REMARK 465     VAD G  3013
REMARK 465     DVA G  3014
REMARK 465     2OP G  3015
REMARK 465     VAL G  3016
REMARK 465     VAD G  3017
REMARK 465     DVA G  3018
REMARK 465     2OP G  3019
REMARK 465     VAL G  3020
REMARK 465     VAD I  3009
REMARK 465     VAD I  3013
REMARK 465     DVA I  3014
REMARK 465     2OP I  3015
REMARK 465     VAL I  3016
REMARK 465     VAD I  3017
REMARK 465     DVA I  3018
REMARK 465     2OP I  3019
REMARK 465     VAL I  3020
REMARK 465     VAD H  3009
REMARK 465     DVA H  3010
REMARK 465     VAD H  3013
REMARK 465     DVA H  3014
REMARK 465     2OP H  3015
REMARK 465     VAL H  3016
REMARK 465     VAD H  3017
REMARK 465     DVA H  3018
REMARK 465     2OP H  3019
REMARK 465     VAL H  3020
REMARK 465     VAD K  3009
REMARK 465     DVA K  3010
REMARK 465     VAD K  3013
REMARK 465     DVA K  3014
REMARK 465     2OP K  3015
REMARK 465     VAL K  3016
REMARK 465     VAD K  3017
REMARK 465     DVA K  3018
REMARK 465     2OP K  3019
REMARK 465     VAL K  3020
REMARK 465     VAD J  3009
REMARK 465     DVA J  3010
REMARK 465     VAD J  3013
REMARK 465     DVA J  3014
REMARK 465     2OP J  3015
REMARK 465     VAL J  3016
REMARK 465     VAD J  3017
REMARK 465     DVA J  3018
REMARK 465     2OP J  3019
REMARK 465     VAL J  3020
REMARK 465     VAD L  3009
REMARK 465     DVA L  3010
REMARK 465     VAD L  3013
REMARK 465     DVA L  3014
REMARK 465     2OP L  3015
REMARK 465     VAL L  3016
REMARK 465     VAD L  3017
REMARK 465     DVA L  3018
REMARK 465     2OP L  3019
REMARK 465     VAL L  3020
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     ASP A2389    CG   OD1  OD2
REMARK 470     LEU A2495    CG   CD1  CD2
REMARK 470     THR A2506    OG1  CG2
REMARK 470     GLU A2507    CG   CD   OE1  OE2
REMARK 470     GLU A2508    CG   CD   OE1  OE2
REMARK 470     GLU A2509    CG   CD   OE1  OE2
REMARK 470     LYS A2511    CG   CD   CE   NZ
REMARK 470     LYS A2531    CG   CD   CE   NZ
REMARK 470     ASP A2532    CG   OD1  OD2
REMARK 470     LEU A2533    CG   CD1  CD2
REMARK 470     LYS A2539    CG   CD   CE   NZ
REMARK 470     ARG A2545    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ARG A2576    CG   CD   NE   CZ   NH1  NH2
REMARK 470     GLN A2582    CG   CD   OE1  NE2
REMARK 470     ARG A2583    CG   CD   NE   CZ   NH1  NH2
REMARK 470     GLU A2600    CG   CD   OE1  OE2
REMARK 470     ARG A2603    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ARG B2494    CG   CD   NE   CZ   NH1  NH2
REMARK 470     GLU B2507    CG   CD   OE1  OE2
REMARK 470     GLU B2508    CG   CD   OE1  OE2
REMARK 470     LYS B2511    CG   CD   CE   NZ
REMARK 470     ASP B2532    CG   OD1  OD2
REMARK 470     LEU B2533    CG   CD1  CD2
REMARK 470     ARG B2576    CG   CD   NE   CZ   NH1  NH2
REMARK 470     VAL B2579    CG1  CG2
REMARK 470     GLU B2600    CG   CD   OE1  OE2
REMARK 470     GLU B2615    CG   CD   OE1  OE2
REMARK 470     ARG B2630    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ASP C2389    CG   OD1  OD2
REMARK 470     ASP C2455    CG   OD1  OD2
REMARK 470     ARG C2494    CG   CD   NE   CZ   NH1  NH2
REMARK 470     LEU C2495    CG   CD1  CD2
REMARK 470     ASP C2497    CG   OD1  OD2
REMARK 470     GLU C2507    CG   CD   OE1  OE2
REMARK 470     GLU C2508    CG   CD   OE1  OE2
REMARK 470     LYS C2511    CG   CD   CE   NZ
REMARK 470     LYS C2531    CG   CD   CE   NZ
REMARK 470     ASP C2532    CG   OD1  OD2
REMARK 470     ARG C2576    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ASP C2577    CG   OD1  OD2
REMARK 470     GLN C2582    CG   CD   OE1  NE2
REMARK 470     ARG D2386    CG   CD   NE   CZ   NH1  NH2
REMARK 470     GLU D2439    CG   CD   OE1  OE2
REMARK 470     ARG D2494    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ASP D2497    CG   OD1  OD2
REMARK 470     GLU D2507    CG   CD   OE1  OE2
REMARK 470     GLU D2508    CG   CD   OE1  OE2
REMARK 470     GLU D2509    CG   CD   OE1  OE2
REMARK 470     LYS D2511    CG   CD   CE   NZ
REMARK 470     ILE D2519    CG1  CG2  CD1
REMARK 470     ASP D2524    CG   OD1  OD2
REMARK 470     GLN D2525    CG   CD   OE1  NE2
REMARK 470     ASP D2526    CG   OD1  OD2
REMARK 470     ARG D2527    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ASP D2532    CG   OD1  OD2
REMARK 470     LEU D2533    CG   CD1  CD2
REMARK 470     ARG D2545    CG   CD   NE   CZ   NH1  NH2
REMARK 470     GLN D2582    CG   CD   OE1  NE2
REMARK 470     GLU D2600    CG   CD   OE1  OE2
REMARK 470     ARG D2630    CG   CD   NE   CZ   NH1  NH2
REMARK 470     LYS E2379    CG   CD   CE   NZ
REMARK 470     ARG E2386    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ARG E2411    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ARG E2494    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ASP E2497    CG   OD1  OD2
REMARK 470     ILE E2498    CG1  CG2  CD1
REMARK 470     GLU E2507    CG   CD   OE1  OE2
REMARK 470     GLU E2508    CG   CD   OE1  OE2
REMARK 470     GLU E2509    CG   CD   OE1  OE2
REMARK 470     THR E2510    OG1  CG2
REMARK 470     LYS E2511    CG   CD   CE   NZ
REMARK 470     ASP E2524    CG   OD1  OD2
REMARK 470     GLN E2525    CG   CD   OE1  NE2
REMARK 470     ASP E2526    CG   OD1  OD2
REMARK 470     ARG E2527    CG   CD   NE   CZ   NH1  NH2
REMARK 470     LYS E2531    CG   CD   CE   NZ
REMARK 470     ASP E2532    CG   OD1  OD2
REMARK 470     ARG E2545    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ARG E2576    CG   CD   NE   CZ   NH1  NH2
REMARK 470     GLN E2582    CG   CD   OE1  NE2
REMARK 470     ARG E2583    CG   CD   NE   CZ   NH1  NH2
REMARK 470     GLU E2600    CG   CD   OE1  OE2
REMARK 470     ARG E2603    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ARG F2386    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ARG F2411    CG   CD   NE   CZ   NH1  NH2
REMARK 470     GLU F2508    CG   CD   OE1  OE2
REMARK 470     GLU F2509    CG   CD   OE1  OE2
REMARK 470     LYS F2511    CG   CD   CE   NZ
REMARK 470     VAL F2512    CG1  CG2
REMARK 470     ASP F2524    CG   OD1  OD2
REMARK 470     GLN F2525    CG   CD   OE1  NE2
REMARK 470     ASP F2526    CG   OD1  OD2
REMARK 470     ARG F2527    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ASP F2528    CG   OD1  OD2
REMARK 470     ASP F2532    CG   OD1  OD2
REMARK 470     LYS F2539    CG   CD   CE   NZ
REMARK 470     ARG F2545    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ARG F2576    CG   CD   NE   CZ   NH1  NH2
REMARK 470     GLN F2582    CG   CD   OE1  NE2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    DPP A2463     -134.00     63.82
REMARK 500    GLN A2582       34.95    -77.25
REMARK 500    ASP A2586       31.63    -86.69
REMARK 500    LEU A2647       80.02   -170.77
REMARK 500    DPP B2463     -137.77     60.54
REMARK 500    ASP B2478        1.88    -68.17
REMARK 500    GLN B2582       81.77    -67.05
REMARK 500    ASN C2384      119.61   -172.07
REMARK 500    DPP C2463     -126.74     61.03
REMARK 500    PHE C2555      -30.02   -131.08
REMARK 500    GLN C2582       88.67    -67.05
REMARK 500    LEU C2647       80.67   -165.39
REMARK 500    VAL D2452      -30.53   -134.33
REMARK 500    DPP D2463     -125.65     57.17
REMARK 500    ASP D2526       53.89   -119.72
REMARK 500    GLN D2582       77.12    -67.92
REMARK 500    DPP E2463     -137.57     64.39
REMARK 500    ASN E2596       62.03   -108.31
REMARK 500    ALA E2626      -60.75    -95.04
REMARK 500    LEU F2383      -38.05   -139.02
REMARK 500    DPP F2463     -136.95     64.08
REMARK 500    MET F2517        5.82    -69.53
REMARK 500    ASP F2526       32.49    -87.24
REMARK 500    CYS F2645      -37.70   -132.38
REMARK 500
REMARK 500 REMARK: NULL
REMARK 525
REMARK 525 SOLVENT
REMARK 525
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 525 NUMBER; I=INSERTION CODE):
REMARK 525
REMARK 525  M RES CSSEQI
REMARK 525    HOH C2735        DISTANCE =  5.83 ANGSTROMS
REMARK 525    HOH D2730        DISTANCE =  6.84 ANGSTROMS
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 6ECB   RELATED DB: PDB
REMARK 900 RELATED ID: 6ECC   RELATED DB: PDB
REMARK 900 RELATED ID: 6ECD   RELATED DB: PDB
REMARK 900 RELATED ID: 6ECE   RELATED DB: PDB
DBREF  6ECF A 2368  2655  UNP    Q1PSF3   Q1PSF3_9ACTN  2368   2655
DBREF  6ECF B 2368  2655  UNP    Q1PSF3   Q1PSF3_9ACTN  2368   2655
DBREF  6ECF C 2368  2655  UNP    Q1PSF3   Q1PSF3_9ACTN  2368   2655
DBREF  6ECF D 2368  2655  UNP    Q1PSF3   Q1PSF3_9ACTN  2368   2655
DBREF  6ECF E 2368  2655  UNP    Q1PSF3   Q1PSF3_9ACTN  2368   2655
DBREF  6ECF F 2368  2655  UNP    Q1PSF3   Q1PSF3_9ACTN  2368   2655
DBREF  6ECF G 3009  3020  PDB    6ECF     6ECF          3009   3020
DBREF  6ECF I 3009  3020  PDB    6ECF     6ECF          3009   3020
DBREF  6ECF H 3009  3020  PDB    6ECF     6ECF          3009   3020
DBREF  6ECF K 3009  3020  PDB    6ECF     6ECF          3009   3020
DBREF  6ECF J 3009  3020  PDB    6ECF     6ECF          3009   3020
DBREF  6ECF L 3009  3020  PDB    6ECF     6ECF          3009   3020
SEQADV 6ECF MET A 2353  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS A 2354  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS A 2355  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS A 2356  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS A 2357  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS A 2358  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS A 2359  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS A 2360  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS A 2361  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF GLU A 2362  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF ASN A 2363  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF LEU A 2364  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF TYR A 2365  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF PHE A 2366  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF GLN A 2367  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF MET B 2353  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS B 2354  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS B 2355  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS B 2356  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS B 2357  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS B 2358  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS B 2359  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS B 2360  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS B 2361  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF GLU B 2362  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF ASN B 2363  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF LEU B 2364  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF TYR B 2365  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF PHE B 2366  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF GLN B 2367  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF MET C 2353  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS C 2354  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS C 2355  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS C 2356  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS C 2357  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS C 2358  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS C 2359  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS C 2360  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS C 2361  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF GLU C 2362  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF ASN C 2363  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF LEU C 2364  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF TYR C 2365  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF PHE C 2366  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF GLN C 2367  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF MET D 2353  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS D 2354  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS D 2355  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS D 2356  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS D 2357  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS D 2358  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS D 2359  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS D 2360  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS D 2361  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF GLU D 2362  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF ASN D 2363  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF LEU D 2364  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF TYR D 2365  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF PHE D 2366  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF GLN D 2367  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF MET E 2353  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS E 2354  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS E 2355  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS E 2356  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS E 2357  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS E 2358  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS E 2359  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS E 2360  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS E 2361  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF GLU E 2362  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF ASN E 2363  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF LEU E 2364  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF TYR E 2365  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF PHE E 2366  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF GLN E 2367  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF MET F 2353  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS F 2354  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS F 2355  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS F 2356  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS F 2357  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS F 2358  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS F 2359  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS F 2360  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF HIS F 2361  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF GLU F 2362  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF ASN F 2363  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF LEU F 2364  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF TYR F 2365  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF PHE F 2366  UNP  Q1PSF3              EXPRESSION TAG
SEQADV 6ECF GLN F 2367  UNP  Q1PSF3              EXPRESSION TAG
SEQRES   1 A  303  MET HIS HIS HIS HIS HIS HIS HIS HIS GLU ASN LEU TYR
SEQRES   2 A  303  PHE GLN GLY GLY SER SER THR ALA GLY ASP PRO THR ALA
SEQRES   3 A  303  LYS LEU VAL ARG LEU ASN PRO ARG GLY GLY ASP GLY PRO
SEQRES   4 A  303  GLY ILE VAL PHE ALA PRO PRO ALA GLY GLY THR VAL LEU
SEQRES   5 A  303  GLY TYR ILE GLU LEU ALA ARG HIS LEU LYS GLY PHE GLY
SEQRES   6 A  303  GLU ILE HIS GLY VAL GLU ALA PRO GLY LEU GLY ALA GLY
SEQRES   7 A  303  GLU THR PRO VAL TYR PRO SER PHE GLU GLU MET VAL GLN
SEQRES   8 A  303  PHE CYS SER ASP SER ALA ALA GLY VAL ALA GLY ASP GLY
SEQRES   9 A  303  VAL TYR ILE GLY GLY HIS DPP LEU GLY GLY HIS ILE ALA
SEQRES  10 A  303  PHE TYR LEU ALA THR MET LEU LEU ASP ARG GLY ILE ARG
SEQRES  11 A  303  PRO LYS GLY LEU ILE ILE LEU ASP THR PRO PRO ARG LEU
SEQRES  12 A  303  GLY ASP ILE PRO VAL ALA ASP ALA ASP LEU THR GLU GLU
SEQRES  13 A  303  GLU THR LYS VAL PHE ILE LEU ALA MET GLY ILE GLY GLY
SEQRES  14 A  303  MET LEU ASP GLN ASP ARG ASP ALA LEU LYS ASP LEU PRO
SEQRES  15 A  303  TYR GLU GLU ALA LYS GLN LEU LEU LEU ASP ARG ALA LYS
SEQRES  16 A  303  ASN ASP PRO ARG VAL SER ALA PHE LEU SER GLU ASP TYR
SEQRES  17 A  303  LEU ASP ARG PHE LEU ARG LEU GLN MET HIS GLN LEU MET
SEQRES  18 A  303  TYR SER ARG ASP VAL VAL LEU PRO GLN ARG LYS LEU ASP
SEQRES  19 A  303  ILE PRO ILE HIS VAL PHE ARG THR LYS ASN HIS ALA PRO
SEQRES  20 A  303  GLU VAL ALA ARG LEU PHE SER ALA TRP GLU ASN TYR ALA
SEQRES  21 A  303  ALA GLY GLU VAL THR PHE VAL ASP ILE PRO GLY ASP HIS
SEQRES  22 A  303  ALA THR MET LEU ARG ALA PRO HIS VAL SER GLU VAL ALA
SEQRES  23 A  303  GLN LEU LEU ASP ARG HIS CYS GLY LEU PRO SER ASP ASP
SEQRES  24 A  303  GLY PRO ARG GLY
SEQRES   1 B  303  MET HIS HIS HIS HIS HIS HIS HIS HIS GLU ASN LEU TYR
SEQRES   2 B  303  PHE GLN GLY GLY SER SER THR ALA GLY ASP PRO THR ALA
SEQRES   3 B  303  LYS LEU VAL ARG LEU ASN PRO ARG GLY GLY ASP GLY PRO
SEQRES   4 B  303  GLY ILE VAL PHE ALA PRO PRO ALA GLY GLY THR VAL LEU
SEQRES   5 B  303  GLY TYR ILE GLU LEU ALA ARG HIS LEU LYS GLY PHE GLY
SEQRES   6 B  303  GLU ILE HIS GLY VAL GLU ALA PRO GLY LEU GLY ALA GLY
SEQRES   7 B  303  GLU THR PRO VAL TYR PRO SER PHE GLU GLU MET VAL GLN
SEQRES   8 B  303  PHE CYS SER ASP SER ALA ALA GLY VAL ALA GLY ASP GLY
SEQRES   9 B  303  VAL TYR ILE GLY GLY HIS DPP LEU GLY GLY HIS ILE ALA
SEQRES  10 B  303  PHE TYR LEU ALA THR MET LEU LEU ASP ARG GLY ILE ARG
SEQRES  11 B  303  PRO LYS GLY LEU ILE ILE LEU ASP THR PRO PRO ARG LEU
SEQRES  12 B  303  GLY ASP ILE PRO VAL ALA ASP ALA ASP LEU THR GLU GLU
SEQRES  13 B  303  GLU THR LYS VAL PHE ILE LEU ALA MET GLY ILE GLY GLY
SEQRES  14 B  303  MET LEU ASP GLN ASP ARG ASP ALA LEU LYS ASP LEU PRO
SEQRES  15 B  303  TYR GLU GLU ALA LYS GLN LEU LEU LEU ASP ARG ALA LYS
SEQRES  16 B  303  ASN ASP PRO ARG VAL SER ALA PHE LEU SER GLU ASP TYR
SEQRES  17 B  303  LEU ASP ARG PHE LEU ARG LEU GLN MET HIS GLN LEU MET
SEQRES  18 B  303  TYR SER ARG ASP VAL VAL LEU PRO GLN ARG LYS LEU ASP
SEQRES  19 B  303  ILE PRO ILE HIS VAL PHE ARG THR LYS ASN HIS ALA PRO
SEQRES  20 B  303  GLU VAL ALA ARG LEU PHE SER ALA TRP GLU ASN TYR ALA
SEQRES  21 B  303  ALA GLY GLU VAL THR PHE VAL ASP ILE PRO GLY ASP HIS
SEQRES  22 B  303  ALA THR MET LEU ARG ALA PRO HIS VAL SER GLU VAL ALA
SEQRES  23 B  303  GLN LEU LEU ASP ARG HIS CYS GLY LEU PRO SER ASP ASP
SEQRES  24 B  303  GLY PRO ARG GLY
SEQRES   1 C  303  MET HIS HIS HIS HIS HIS HIS HIS HIS GLU ASN LEU TYR
SEQRES   2 C  303  PHE GLN GLY GLY SER SER THR ALA GLY ASP PRO THR ALA
SEQRES   3 C  303  LYS LEU VAL ARG LEU ASN PRO ARG GLY GLY ASP GLY PRO
SEQRES   4 C  303  GLY ILE VAL PHE ALA PRO PRO ALA GLY GLY THR VAL LEU
SEQRES   5 C  303  GLY TYR ILE GLU LEU ALA ARG HIS LEU LYS GLY PHE GLY
SEQRES   6 C  303  GLU ILE HIS GLY VAL GLU ALA PRO GLY LEU GLY ALA GLY
SEQRES   7 C  303  GLU THR PRO VAL TYR PRO SER PHE GLU GLU MET VAL GLN
SEQRES   8 C  303  PHE CYS SER ASP SER ALA ALA GLY VAL ALA GLY ASP GLY
SEQRES   9 C  303  VAL TYR ILE GLY GLY HIS DPP LEU GLY GLY HIS ILE ALA
SEQRES  10 C  303  PHE TYR LEU ALA THR MET LEU LEU ASP ARG GLY ILE ARG
SEQRES  11 C  303  PRO LYS GLY LEU ILE ILE LEU ASP THR PRO PRO ARG LEU
SEQRES  12 C  303  GLY ASP ILE PRO VAL ALA ASP ALA ASP LEU THR GLU GLU
SEQRES  13 C  303  GLU THR LYS VAL PHE ILE LEU ALA MET GLY ILE GLY GLY
SEQRES  14 C  303  MET LEU ASP GLN ASP ARG ASP ALA LEU LYS ASP LEU PRO
SEQRES  15 C  303  TYR GLU GLU ALA LYS GLN LEU LEU LEU ASP ARG ALA LYS
SEQRES  16 C  303  ASN ASP PRO ARG VAL SER ALA PHE LEU SER GLU ASP TYR
SEQRES  17 C  303  LEU ASP ARG PHE LEU ARG LEU GLN MET HIS GLN LEU MET
SEQRES  18 C  303  TYR SER ARG ASP VAL VAL LEU PRO GLN ARG LYS LEU ASP
SEQRES  19 C  303  ILE PRO ILE HIS VAL PHE ARG THR LYS ASN HIS ALA PRO
SEQRES  20 C  303  GLU VAL ALA ARG LEU PHE SER ALA TRP GLU ASN TYR ALA
SEQRES  21 C  303  ALA GLY GLU VAL THR PHE VAL ASP ILE PRO GLY ASP HIS
SEQRES  22 C  303  ALA THR MET LEU ARG ALA PRO HIS VAL SER GLU VAL ALA
SEQRES  23 C  303  GLN LEU LEU ASP ARG HIS CYS GLY LEU PRO SER ASP ASP
SEQRES  24 C  303  GLY PRO ARG GLY
SEQRES   1 D  303  MET HIS HIS HIS HIS HIS HIS HIS HIS GLU ASN LEU TYR
SEQRES   2 D  303  PHE GLN GLY GLY SER SER THR ALA GLY ASP PRO THR ALA
SEQRES   3 D  303  LYS LEU VAL ARG LEU ASN PRO ARG GLY GLY ASP GLY PRO
SEQRES   4 D  303  GLY ILE VAL PHE ALA PRO PRO ALA GLY GLY THR VAL LEU
SEQRES   5 D  303  GLY TYR ILE GLU LEU ALA ARG HIS LEU LYS GLY PHE GLY
SEQRES   6 D  303  GLU ILE HIS GLY VAL GLU ALA PRO GLY LEU GLY ALA GLY
SEQRES   7 D  303  GLU THR PRO VAL TYR PRO SER PHE GLU GLU MET VAL GLN
SEQRES   8 D  303  PHE CYS SER ASP SER ALA ALA GLY VAL ALA GLY ASP GLY
SEQRES   9 D  303  VAL TYR ILE GLY GLY HIS DPP LEU GLY GLY HIS ILE ALA
SEQRES  10 D  303  PHE TYR LEU ALA THR MET LEU LEU ASP ARG GLY ILE ARG
SEQRES  11 D  303  PRO LYS GLY LEU ILE ILE LEU ASP THR PRO PRO ARG LEU
SEQRES  12 D  303  GLY ASP ILE PRO VAL ALA ASP ALA ASP LEU THR GLU GLU
SEQRES  13 D  303  GLU THR LYS VAL PHE ILE LEU ALA MET GLY ILE GLY GLY
SEQRES  14 D  303  MET LEU ASP GLN ASP ARG ASP ALA LEU LYS ASP LEU PRO
SEQRES  15 D  303  TYR GLU GLU ALA LYS GLN LEU LEU LEU ASP ARG ALA LYS
SEQRES  16 D  303  ASN ASP PRO ARG VAL SER ALA PHE LEU SER GLU ASP TYR
SEQRES  17 D  303  LEU ASP ARG PHE LEU ARG LEU GLN MET HIS GLN LEU MET
SEQRES  18 D  303  TYR SER ARG ASP VAL VAL LEU PRO GLN ARG LYS LEU ASP
SEQRES  19 D  303  ILE PRO ILE HIS VAL PHE ARG THR LYS ASN HIS ALA PRO
SEQRES  20 D  303  GLU VAL ALA ARG LEU PHE SER ALA TRP GLU ASN TYR ALA
SEQRES  21 D  303  ALA GLY GLU VAL THR PHE VAL ASP ILE PRO GLY ASP HIS
SEQRES  22 D  303  ALA THR MET LEU ARG ALA PRO HIS VAL SER GLU VAL ALA
SEQRES  23 D  303  GLN LEU LEU ASP ARG HIS CYS GLY LEU PRO SER ASP ASP
SEQRES  24 D  303  GLY PRO ARG GLY
SEQRES   1 E  303  MET HIS HIS HIS HIS HIS HIS HIS HIS GLU ASN LEU TYR
SEQRES   2 E  303  PHE GLN GLY GLY SER SER THR ALA GLY ASP PRO THR ALA
SEQRES   3 E  303  LYS LEU VAL ARG LEU ASN PRO ARG GLY GLY ASP GLY PRO
SEQRES   4 E  303  GLY ILE VAL PHE ALA PRO PRO ALA GLY GLY THR VAL LEU
SEQRES   5 E  303  GLY TYR ILE GLU LEU ALA ARG HIS LEU LYS GLY PHE GLY
SEQRES   6 E  303  GLU ILE HIS GLY VAL GLU ALA PRO GLY LEU GLY ALA GLY
SEQRES   7 E  303  GLU THR PRO VAL TYR PRO SER PHE GLU GLU MET VAL GLN
SEQRES   8 E  303  PHE CYS SER ASP SER ALA ALA GLY VAL ALA GLY ASP GLY
SEQRES   9 E  303  VAL TYR ILE GLY GLY HIS DPP LEU GLY GLY HIS ILE ALA
SEQRES  10 E  303  PHE TYR LEU ALA THR MET LEU LEU ASP ARG GLY ILE ARG
SEQRES  11 E  303  PRO LYS GLY LEU ILE ILE LEU ASP THR PRO PRO ARG LEU
SEQRES  12 E  303  GLY ASP ILE PRO VAL ALA ASP ALA ASP LEU THR GLU GLU
SEQRES  13 E  303  GLU THR LYS VAL PHE ILE LEU ALA MET GLY ILE GLY GLY
SEQRES  14 E  303  MET LEU ASP GLN ASP ARG ASP ALA LEU LYS ASP LEU PRO
SEQRES  15 E  303  TYR GLU GLU ALA LYS GLN LEU LEU LEU ASP ARG ALA LYS
SEQRES  16 E  303  ASN ASP PRO ARG VAL SER ALA PHE LEU SER GLU ASP TYR
SEQRES  17 E  303  LEU ASP ARG PHE LEU ARG LEU GLN MET HIS GLN LEU MET
SEQRES  18 E  303  TYR SER ARG ASP VAL VAL LEU PRO GLN ARG LYS LEU ASP
SEQRES  19 E  303  ILE PRO ILE HIS VAL PHE ARG THR LYS ASN HIS ALA PRO
SEQRES  20 E  303  GLU VAL ALA ARG LEU PHE SER ALA TRP GLU ASN TYR ALA
SEQRES  21 E  303  ALA GLY GLU VAL THR PHE VAL ASP ILE PRO GLY ASP HIS
SEQRES  22 E  303  ALA THR MET LEU ARG ALA PRO HIS VAL SER GLU VAL ALA
SEQRES  23 E  303  GLN LEU LEU ASP ARG HIS CYS GLY LEU PRO SER ASP ASP
SEQRES  24 E  303  GLY PRO ARG GLY
SEQRES   1 F  303  MET HIS HIS HIS HIS HIS HIS HIS HIS GLU ASN LEU TYR
SEQRES   2 F  303  PHE GLN GLY GLY SER SER THR ALA GLY ASP PRO THR ALA
SEQRES   3 F  303  LYS LEU VAL ARG LEU ASN PRO ARG GLY GLY ASP GLY PRO
SEQRES   4 F  303  GLY ILE VAL PHE ALA PRO PRO ALA GLY GLY THR VAL LEU
SEQRES   5 F  303  GLY TYR ILE GLU LEU ALA ARG HIS LEU LYS GLY PHE GLY
SEQRES   6 F  303  GLU ILE HIS GLY VAL GLU ALA PRO GLY LEU GLY ALA GLY
SEQRES   7 F  303  GLU THR PRO VAL TYR PRO SER PHE GLU GLU MET VAL GLN
SEQRES   8 F  303  PHE CYS SER ASP SER ALA ALA GLY VAL ALA GLY ASP GLY
SEQRES   9 F  303  VAL TYR ILE GLY GLY HIS DPP LEU GLY GLY HIS ILE ALA
SEQRES  10 F  303  PHE TYR LEU ALA THR MET LEU LEU ASP ARG GLY ILE ARG
SEQRES  11 F  303  PRO LYS GLY LEU ILE ILE LEU ASP THR PRO PRO ARG LEU
SEQRES  12 F  303  GLY ASP ILE PRO VAL ALA ASP ALA ASP LEU THR GLU GLU
SEQRES  13 F  303  GLU THR LYS VAL PHE ILE LEU ALA MET GLY ILE GLY GLY
SEQRES  14 F  303  MET LEU ASP GLN ASP ARG ASP ALA LEU LYS ASP LEU PRO
SEQRES  15 F  303  TYR GLU GLU ALA LYS GLN LEU LEU LEU ASP ARG ALA LYS
SEQRES  16 F  303  ASN ASP PRO ARG VAL SER ALA PHE LEU SER GLU ASP TYR
SEQRES  17 F  303  LEU ASP ARG PHE LEU ARG LEU GLN MET HIS GLN LEU MET
SEQRES  18 F  303  TYR SER ARG ASP VAL VAL LEU PRO GLN ARG LYS LEU ASP
SEQRES  19 F  303  ILE PRO ILE HIS VAL PHE ARG THR LYS ASN HIS ALA PRO
SEQRES  20 F  303  GLU VAL ALA ARG LEU PHE SER ALA TRP GLU ASN TYR ALA
SEQRES  21 F  303  ALA GLY GLU VAL THR PHE VAL ASP ILE PRO GLY ASP HIS
SEQRES  22 F  303  ALA THR MET LEU ARG ALA PRO HIS VAL SER GLU VAL ALA
SEQRES  23 F  303  GLN LEU LEU ASP ARG HIS CYS GLY LEU PRO SER ASP ASP
SEQRES  24 F  303  GLY PRO ARG GLY
SEQRES   1 G   12  VAD DVA 2OP VAL VAD DVA 2OP VAL VAD DVA 2OP VAL
SEQRES   1 I   12  VAD DVA 2OP VAL VAD DVA 2OP VAL VAD DVA 2OP VAL
SEQRES   1 H   12  VAD DVA 2OP VAL VAD DVA 2OP VAL VAD DVA 2OP VAL
SEQRES   1 K   12  VAD DVA 2OP VAL VAD DVA 2OP VAL VAD DVA 2OP VAL
SEQRES   1 J   12  VAD DVA 2OP VAL VAD DVA 2OP VAL VAD DVA 2OP VAL
SEQRES   1 L   12  VAD DVA 2OP VAL VAD DVA 2OP VAL VAD DVA 2OP VAL
MODRES 6ECF DPP A 2463  SER  MODIFIED RESIDUE
MODRES 6ECF DPP B 2463  SER  MODIFIED RESIDUE
MODRES 6ECF DPP C 2463  SER  MODIFIED RESIDUE
MODRES 6ECF DPP D 2463  SER  MODIFIED RESIDUE
MODRES 6ECF DPP E 2463  SER  MODIFIED RESIDUE
MODRES 6ECF DPP F 2463  SER  MODIFIED RESIDUE
HET    DPP  A2463      10
HET    DPP  B2463      10
HET    DPP  C2463      10
HET    DPP  D2463      10
HET    DPP  E2463      10
HET    DPP  F2463      10
HET    VAD  G3009      16
HET    DVA  G3010      15
HET    2OP  G3011       9
HET    DVA  I3010      16
HET    2OP  I3011       9
HET    2OP  H3011       9
HET    2OP  K3011       9
HET    2OP  J3011       9
HET    2OP  L3011       9
HETNAM     DPP DIAMINOPROPANOIC ACID
HETNAM     VAD DEAMINOHYDROXYVALINE
HETNAM     DVA D-VALINE
HETNAM     2OP (2S)-2-HYDROXYPROPANOIC ACID
FORMUL   1  DPP    6(C3 H8 N2 O2)
FORMUL   7  VAD    C5 H10 O3
FORMUL   7  DVA    2(C5 H11 N O2)
FORMUL   7  2OP    6(C3 H6 O3)
FORMUL  13  HOH   *206(H2 O)
HELIX    1 AA1 ASP A 2375  ALA A 2378  5                                   4
HELIX    2 AA2 VAL A 2403  GLY A 2405  5                                   3
HELIX    3 AA3 TYR A 2406  LEU A 2413  1                                   8
HELIX    4 AA4 SER A 2437  ALA A 2450  1                                  14
HELIX    5 AA5 GLY A 2451  VAL A 2452  5                                   2
HELIX    6 AA6 ALA A 2453  ASP A 2455  5                                   3
HELIX    7 AA7 DPP A 2463  ARG A 2479  1                                  17
HELIX    8 AA8 GLU A 2507  MET A 2517  1                                  11
HELIX    9 AA9 PRO A 2534  ASP A 2549  1                                  16
HELIX   10 AB1 ASP A 2549  LEU A 2556  1                                   8
HELIX   11 AB2 SER A 2557  SER A 2575  1                                  19
HELIX   12 AB3 ARG A 2576  VAL A 2578  5                                   3
HELIX   13 AB4 ALA A 2598  ARG A 2603  1                                   6
HELIX   14 AB5 LEU A 2604  ALA A 2612  5                                   9
HELIX   15 AB6 ALA A 2626  ARG A 2630  5                                   5
HELIX   16 AB7 PRO A 2632  CYS A 2645  1                                  14
HELIX   17 AB8 PRO B 2376  ALA B 2378  5                                   3
HELIX   18 AB9 VAL B 2403  GLY B 2405  5                                   3
HELIX   19 AC1 TYR B 2406  LEU B 2413  1                                   8
HELIX   20 AC2 SER B 2437  GLY B 2454  1                                  18
HELIX   21 AC3 DPP B 2463  ASP B 2478  1                                  16
HELIX   22 AC4 GLU B 2507  GLY B 2518  1                                  12
HELIX   23 AC5 PRO B 2534  ASP B 2549  1                                  16
HELIX   24 AC6 ASP B 2549  LEU B 2556  1                                   8
HELIX   25 AC7 SER B 2557  TYR B 2574  1                                  18
HELIX   26 AC8 SER B 2575  VAL B 2578  5                                   4
HELIX   27 AC9 ALA B 2598  ARG B 2603  1                                   6
HELIX   28 AD1 LEU B 2604  ALA B 2612  5                                   9
HELIX   29 AD2 ALA B 2626  ARG B 2630  5                                   5
HELIX   30 AD3 HIS B 2633  CYS B 2645  1                                  13
HELIX   31 AD4 PRO C 2376  ALA C 2378  5                                   3
HELIX   32 AD5 VAL C 2403  GLY C 2405  5                                   3
HELIX   33 AD6 TYR C 2406  LEU C 2413  1                                   8
HELIX   34 AD7 SER C 2437  ALA C 2450  1                                  14
HELIX   35 AD8 GLY C 2451  ASP C 2455  5                                   5
HELIX   36 AD9 DPP C 2463  ARG C 2479  1                                  17
HELIX   37 AE1 GLU C 2508  MET C 2517  1                                  10
HELIX   38 AE2 PRO C 2534  ASP C 2549  1                                  16
HELIX   39 AE3 ASP C 2549  LEU C 2556  1                                   8
HELIX   40 AE4 SER C 2557  TYR C 2574  1                                  18
HELIX   41 AE5 ALA C 2598  ARG C 2603  1                                   6
HELIX   42 AE6 LEU C 2604  ALA C 2612  5                                   9
HELIX   43 AE7 ALA C 2626  ARG C 2630  5                                   5
HELIX   44 AE8 HIS C 2633  GLY C 2646  1                                  14
HELIX   45 AE9 VAL D 2403  GLY D 2405  5                                   3
HELIX   46 AF1 TYR D 2406  HIS D 2412  1                                   7
HELIX   47 AF2 SER D 2437  ALA D 2450  1                                  14
HELIX   48 AF3 DPP D 2463  ARG D 2479  1                                  17
HELIX   49 AF4 GLU D 2507  MET D 2517  1                                  11
HELIX   50 AF5 ASP D 2526  LYS D 2531  1                                   6
HELIX   51 AF6 PRO D 2534  ASN D 2548  1                                  15
HELIX   52 AF7 ASP D 2549  LEU D 2556  1                                   8
HELIX   53 AF8 SER D 2557  ARG D 2576  1                                  20
HELIX   54 AF9 ALA D 2598  SER D 2606  1                                   9
HELIX   55 AG1 ALA D 2607  ALA D 2612  5                                   6
HELIX   56 AG2 ALA D 2626  ARG D 2630  5                                   5
HELIX   57 AG3 PRO D 2632  GLY D 2646  1                                  15
HELIX   58 AG4 VAL E 2403  GLY E 2405  5                                   3
HELIX   59 AG5 TYR E 2406  LEU E 2413  1                                   8
HELIX   60 AG6 SER E 2437  ALA E 2450  1                                  14
HELIX   61 AG7 DPP E 2463  ARG E 2479  1                                  17
HELIX   62 AG8 ARG E 2494  ILE E 2498  5                                   5
HELIX   63 AG9 GLU E 2508  MET E 2517  1                                  10
HELIX   64 AH1 ASP E 2526  LEU E 2533  1                                   8
HELIX   65 AH2 PRO E 2534  ASN E 2548  1                                  15
HELIX   66 AH3 ASP E 2549  LEU E 2556  1                                   8
HELIX   67 AH4 SER E 2557  TYR E 2574  1                                  18
HELIX   68 AH5 SER E 2575  VAL E 2578  5                                   4
HELIX   69 AH6 GLU E 2600  LEU E 2604  1                                   5
HELIX   70 AH7 PHE E 2605  ALA E 2612  5                                   8
HELIX   71 AH8 ALA E 2626  ARG E 2630  5                                   5
HELIX   72 AH9 HIS E 2633  GLY E 2646  1                                  14
HELIX   73 AI1 PRO F 2376  ALA F 2378  5                                   3
HELIX   74 AI2 VAL F 2403  GLY F 2405  5                                   3
HELIX   75 AI3 TYR F 2406  LEU F 2413  1                                   8
HELIX   76 AI4 SER F 2437  ALA F 2450  1                                  14
HELIX   77 AI5 DPP F 2463  ASP F 2478  1                                  16
HELIX   78 AI6 GLU F 2509  MET F 2517  1                                   9
HELIX   79 AI7 ASP F 2526  LEU F 2533  1                                   8
HELIX   80 AI8 PRO F 2534  ASN F 2548  1                                  15
HELIX   81 AI9 ASP F 2549  LEU F 2556  1                                   8
HELIX   82 AJ1 SER F 2557  TYR F 2574  1                                  18
HELIX   83 AJ2 ALA F 2598  ARG F 2603  1                                   6
HELIX   84 AJ3 LEU F 2604  ALA F 2612  5                                   9
HELIX   85 AJ4 ALA F 2626  ARG F 2630  5                                   5
HELIX   86 AJ5 PRO F 2632  CYS F 2645  1                                  14
SHEET    1 AA114 LEU A2380  ASN A2384  0
SHEET    2 AA114 ILE A2419  VAL A2422 -1  O  GLY A2421   N  VAL A2381
SHEET    3 AA114 GLY A2392  ALA A2396  1  N  ILE A2393   O  HIS A2420
SHEET    4 AA114 VAL A2457  HIS A2462  1  O  TYR A2458   N  GLY A2392
SHEET    5 AA114 GLY A2485  LEU A2489  1  O  GLY A2485   N  ILE A2459
SHEET    6 AA114 ILE A2589  THR A2594  1  O  HIS A2590   N  LEU A2486
SHEET    7 AA114 GLU A2615  ILE A2621  1  O  THR A2617   N  VAL A2591
SHEET    8 AA114 VAL E2616  ILE E2621  1  O  PHE E2618   N  VAL A2616
SHEET    9 AA114 ILE E2589  THR E2594  1  N  VAL E2591   O  THR E2617
SHEET   10 AA114 GLY E2485  LEU E2489  1  N  ILE E2488   O  HIS E2590
SHEET   11 AA114 TYR E2458  HIS E2462  1  N  ILE E2459   O  ILE E2487
SHEET   12 AA114 ILE E2393  ALA E2396  1  N  ALA E2396   O  GLY E2460
SHEET   13 AA114 ILE E2419  VAL E2422  1  O  HIS E2420   N  ILE E2393
SHEET   14 AA114 LEU E2380  ARG E2382 -1  N  VAL E2381   O  GLY E2421
SHEET    1 AA214 LEU B2380  ASN B2384  0
SHEET    2 AA214 ILE B2419  VAL B2422 -1  O  GLY B2421   N  VAL B2381
SHEET    3 AA214 GLY B2392  ALA B2396  1  N  ILE B2393   O  HIS B2420
SHEET    4 AA214 VAL B2457  HIS B2462  1  O  GLY B2460   N  VAL B2394
SHEET    5 AA214 GLY B2485  LEU B2489  1  O  ILE B2487   N  ILE B2459
SHEET    6 AA214 ILE B2589  ARG B2593  1  O  HIS B2590   N  ILE B2488
SHEET    7 AA214 GLU B2615  ASP B2620  1  O  THR B2617   N  VAL B2591
SHEET    8 AA214 VAL F2616  ILE F2621  1  O  PHE F2618   N  PHE B2618
SHEET    9 AA214 ILE F2589  THR F2594  1  N  VAL F2591   O  THR F2617
SHEET   10 AA214 GLY F2485  LEU F2489  1  N  ILE F2488   O  PHE F2592
SHEET   11 AA214 TYR F2458  HIS F2462  1  N  ILE F2459   O  ILE F2487
SHEET   12 AA214 ILE F2393  ALA F2396  1  N  VAL F2394   O  GLY F2460
SHEET   13 AA214 ILE F2419  VAL F2422  1  O  HIS F2420   N  ILE F2393
SHEET   14 AA214 LEU F2380  ARG F2382 -1  N  VAL F2381   O  GLY F2421
SHEET    1 AA314 LEU C2380  ASN C2384  0
SHEET    2 AA314 ILE C2419  VAL C2422 -1  O  GLY C2421   N  VAL C2381
SHEET    3 AA314 GLY C2392  ALA C2396  1  N  ILE C2393   O  HIS C2420
SHEET    4 AA314 VAL C2457  HIS C2462  1  O  TYR C2458   N  VAL C2394
SHEET    5 AA314 GLY C2485  LEU C2489  1  O  ILE C2487   N  ILE C2459
SHEET    6 AA314 ILE C2589  THR C2594  1  O  HIS C2590   N  LEU C2486
SHEET    7 AA314 GLU C2615  ILE C2621  1  O  THR C2617   N  VAL C2591
SHEET    8 AA314 VAL D2616  ILE D2621  1  O  PHE D2618   N  PHE C2618
SHEET    9 AA314 ILE D2589  THR D2594  1  N  VAL D2591   O  THR D2617
SHEET   10 AA314 GLY D2485  LEU D2489  1  N  ILE D2488   O  HIS D2590
SHEET   11 AA314 VAL D2457  HIS D2462  1  N  ILE D2459   O  ILE D2487
SHEET   12 AA314 GLY D2392  ALA D2396  1  N  GLY D2392   O  TYR D2458
SHEET   13 AA314 ILE D2419  VAL D2422  1  O  HIS D2420   N  ILE D2393
SHEET   14 AA314 LEU D2380  ARG D2382 -1  N  VAL D2381   O  GLY D2421
LINK         C   HIS A2462                 N   DPP A2463     1555   1555  1.33
LINK         C   DPP A2463                 N   LEU A2464     1555   1555  1.33
LINK         NG  DPP A2463                 C   VAL G3012     1555   1555  1.34
LINK         C   HIS B2462                 N   DPP B2463     1555   1555  1.33
LINK         C   DPP B2463                 N   LEU B2464     1555   1555  1.33
LINK         NG  DPP B2463                 C   VAL I3012     1555   1555  1.34
LINK         C   HIS C2462                 N   DPP C2463     1555   1555  1.33
LINK         C   DPP C2463                 N   LEU C2464     1555   1555  1.33
LINK         NG  DPP C2463                 C   VAL H3012     1555   1555  1.33
LINK         C   HIS D2462                 N   DPP D2463     1555   1555  1.33
LINK         C   DPP D2463                 N   LEU D2464     1555   1555  1.33
LINK         NG  DPP D2463                 C   VAL K3012     1555   1555  1.34
LINK         C   HIS E2462                 N   DPP E2463     1555   1555  1.33
LINK         C   DPP E2463                 N   LEU E2464     1555   1555  1.33
LINK         NG  DPP E2463                 C   VAL J3012     1555   1555  1.34
LINK         C   HIS F2462                 N   DPP F2463     1555   1555  1.33
LINK         C   DPP F2463                 N   LEU F2464     1555   1555  1.33
LINK         NG  DPP F2463                 C   VAL L3012     1555   1555  1.33
LINK         C   VAD G3009                 N   DVA G3010     1555   1555  1.34
LINK         C   DVA G3010                 OHN 2OP G3011     1555   1555  1.33
LINK         C   2OP G3011                 N   VAL G3012     1555   1555  1.33
LINK         C   DVA I3010                 OHN 2OP I3011     1555   1555  1.34
LINK         C   2OP I3011                 N   VAL I3012     1555   1555  1.34
LINK         C   2OP H3011                 N   VAL H3012     1555   1555  1.34
LINK         C   2OP K3011                 N   VAL K3012     1555   1555  1.33
LINK         C   2OP J3011                 N   VAL J3012     1555   1555  1.33
LINK         C   2OP L3011                 N   VAL L3012     1555   1555  1.34
CISPEP   1 ALA A 2631    PRO A 2632          0         3.25
CISPEP   2 ALA B 2631    PRO B 2632          0         1.64
CISPEP   3 ALA C 2631    PRO C 2632          0         3.39
CISPEP   4 LEU D 2533    PRO D 2534          0        -5.60
CISPEP   5 ALA D 2631    PRO D 2632          0         2.07
CISPEP   6 LEU E 2533    PRO E 2534          0        -1.09
CISPEP   7 ALA E 2631    PRO E 2632          0        -0.71
CISPEP   8 LEU F 2533    PRO F 2534          0        -5.23
CISPEP   9 ALA F 2631    PRO F 2632          0         2.42
CRYST1   76.996   77.129   90.329  91.77 114.89 117.94 P 1           6
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.012988  0.006888  0.008329        0.00000
SCALE2      0.000000  0.014676  0.004355        0.00000
SCALE3      0.000000  0.000000  0.012730        0.00000
TER    3676      PRO A2648
TER    7415      SER B2649
TER   11161      PRO C2648
TER   15025      LEU D2647
TER   18784      SER E2649
TER   22606      LEU F2647
TER   22663      VAL G3012
TER   22705      VAL I3012
TER   22731      VAL H3012
TER   22757      VAL K3012
TER   22783      VAL J3012
TER   22809      VAL L3012
MASTER      737    0   15   86   42    0    0    611750   12  185  150
END