longtext: 6f25-pdb

content
HEADER    HYDROLASE                               23-NOV-17   6F25
TITLE     CRYSTAL STRUCTURE OF HUMAN ACETYLCHOLINESTERASE IN COMPLEX WITH C35.
CAVEAT     6F25    FUC A 603 HAS WRONG CHIRALITY AT ATOM C1 FUC B 603 HAS WRONG
CAVEAT   2 6F25    CHIRALITY AT ATOM C1
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: ACETYLCHOLINESTERASE;
COMPND   3 CHAIN: A, B;
COMPND   4 SYNONYM: ACHE;
COMPND   5 EC: 3.1.1.7;
COMPND   6 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE   3 ORGANISM_COMMON: HUMAN;
SOURCE   4 ORGANISM_TAXID: 9606;
SOURCE   5 GENE: ACHE;
SOURCE   6 EXPRESSION_SYSTEM: CRICETULUS GRISEUS;
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 10029
KEYWDS    ACETYLCHOLINESTERASE, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    J.DIAS,F.NACHON
REVDAT   1   12-DEC-18 6F25    0
JRNL        AUTH   J.DIAS,F.NACHON
JRNL        TITL   CRYSTAL STRUCTURE OF HUMAN ACETYLCHOLINESTERASE IN COMPLEX
JRNL        TITL 2 WITH C35.
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   2
REMARK   2 RESOLUTION.    3.05 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX 1.12_2829
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : GEOSTD + MONOMER LIBRARY + CDL V1.2
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 3.05
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 48.89
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.338
REMARK   3   COMPLETENESS FOR RANGE        (%) : 98.7
REMARK   3   NUMBER OF REFLECTIONS             : 55159
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.180
REMARK   3   R VALUE            (WORKING SET) : 0.178
REMARK   3   FREE R VALUE                     : 0.214
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.978
REMARK   3   FREE R VALUE TEST SET COUNT      : 2746
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 48.8951 -  8.2717    1.00     2744   118  0.1800 0.1919
REMARK   3     2  8.2717 -  6.5705    1.00     2705   143  0.1657 0.2088
REMARK   3     3  6.5705 -  5.7414    1.00     2686   125  0.1668 0.1970
REMARK   3     4  5.7414 -  5.2171    1.00     2635   152  0.1542 0.1666
REMARK   3     5  5.2171 -  4.8436    1.00     2646   158  0.1359 0.1609
REMARK   3     6  4.8436 -  4.5582    1.00     2665   125  0.1284 0.1543
REMARK   3     7  4.5582 -  4.3301    1.00     2677   135  0.1312 0.1695
REMARK   3     8  4.3301 -  4.1417    1.00     2631   132  0.1417 0.1875
REMARK   3     9  4.1417 -  3.9823    1.00     2660   129  0.1476 0.1781
REMARK   3    10  3.9823 -  3.8450    1.00     2671   142  0.1604 0.2049
REMARK   3    11  3.8450 -  3.7248    1.00     2634   135  0.1688 0.2369
REMARK   3    12  3.7248 -  3.6183    1.00     2631   167  0.1816 0.2415
REMARK   3    13  3.6183 -  3.5231    1.00     2667   115  0.2059 0.2343
REMARK   3    14  3.5231 -  3.4372    1.00     2612   156  0.2323 0.2944
REMARK   3    15  3.4372 -  3.3591    1.00     2652   137  0.2429 0.2634
REMARK   3    16  3.3591 -  3.2876    1.00     2624   147  0.2518 0.3086
REMARK   3    17  3.2876 -  3.2218    1.00     2625   142  0.2764 0.3401
REMARK   3    18  3.2218 -  3.1611    0.97     2564   146  0.3066 0.3294
REMARK   3    19  3.1611 -  3.1046    0.93     2434   125  0.3487 0.4423
REMARK   3    20  3.1046 -  3.0520    0.85     2250   117  0.3711 0.3994
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL
REMARK   3   SOLVENT RADIUS     : 1.11
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.414
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 23.631
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 78.55
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 80.71
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :  0.003           8858
REMARK   3   ANGLE     :  0.734          12139
REMARK   3   CHIRALITY :  0.044           1296
REMARK   3   PLANARITY :  0.005           1579
REMARK   3   DIHEDRAL  :  9.517           7009
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 6F25 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 23-NOV-17.
REMARK 100 THE DEPOSITION ID IS D_1200007596.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 21-JUL-17
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 7
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : ESRF
REMARK 200  BEAMLINE                       : ID23-2
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.87313
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : PIXEL
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS PILATUS3 2M
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : MOSFLM
REMARK 200  DATA SCALING SOFTWARE          : SCALA
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 55240
REMARK 200  RESOLUTION RANGE HIGH      (A) : 3.050
REMARK 200  RESOLUTION RANGE LOW       (A) : 48.890
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 98.9
REMARK 200  DATA REDUNDANCY                : 11.90
REMARK 200  R MERGE                    (I) : 0.05284
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 11.6000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 3.05
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 3.16
REMARK 200  COMPLETENESS FOR SHELL     (%) : NULL
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL
REMARK 200  R MERGE FOR SHELL          (I) : 0.66060
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: 3LII
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 80.58
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 6.33
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 1.5 M LISO4, 100 MM HEPES PH 7, 60 MM
REMARK 280  MGSO4, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 293K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 61
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -Y,X-Y,Z+1/3
REMARK 290       3555   -X+Y,-X,Z+2/3
REMARK 290       4555   -X,-Y,Z+1/2
REMARK 290       5555   Y,-X+Y,Z+5/6
REMARK 290       6555   X-Y,X,Z+1/6
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -0.500000 -0.866025  0.000000        0.00000
REMARK 290   SMTRY2   2  0.866025 -0.500000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       38.57500
REMARK 290   SMTRY1   3 -0.500000  0.866025  0.000000        0.00000
REMARK 290   SMTRY2   3 -0.866025 -0.500000  0.000000        0.00000
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000       77.15000
REMARK 290   SMTRY1   4 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   4  0.000000  0.000000  1.000000       57.86250
REMARK 290   SMTRY1   5  0.500000  0.866025  0.000000        0.00000
REMARK 290   SMTRY2   5 -0.866025  0.500000  0.000000        0.00000
REMARK 290   SMTRY3   5  0.000000  0.000000  1.000000       96.43750
REMARK 290   SMTRY1   6  0.500000 -0.866025  0.000000        0.00000
REMARK 290   SMTRY2   6  0.866025  0.500000  0.000000        0.00000
REMARK 290   SMTRY3   6  0.000000  0.000000  1.000000       19.28750
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 9030 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 39340 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -300.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     PRO A   259
REMARK 465     GLY A   260
REMARK 465     GLY A   261
REMARK 465     THR A   262
REMARK 465     GLY A   263
REMARK 465     GLY A   264
REMARK 465     GLY B   260
REMARK 465     GLY B   261
REMARK 465     THR B   262
REMARK 465     GLY B   263
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     ARG A 493    CB   CG   CD   NE   CZ   NH1  NH2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   O3   NAG A   604     O5   NAG A   605              2.09
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    PHE A  47       -6.71     70.98
REMARK 500    ASP A  61       88.70    -66.84
REMARK 500    ALA A  62       37.08    -96.57
REMARK 500    PHE A 123       12.76     56.62
REMARK 500    PHE A 158       11.34   -144.27
REMARK 500    SER A 203     -125.21     59.40
REMARK 500    ASP A 306      -81.97    -98.78
REMARK 500    VAL A 407      -59.93   -121.49
REMARK 500    TYR A 449       30.06    -97.83
REMARK 500    ASN A 464       46.77    -94.03
REMARK 500    PHE B  47       -0.01     70.58
REMARK 500    ALA B  62       43.37    -90.01
REMARK 500    PRO B 106       87.43    -66.01
REMARK 500    PHE B 123       11.24     59.84
REMARK 500    ALA B 127      145.76   -170.09
REMARK 500    PHE B 158       15.03   -145.90
REMARK 500    ASN B 170       16.99     59.20
REMARK 500    SER B 196       64.09   -153.14
REMARK 500    SER B 203     -127.19     59.75
REMARK 500    ASP B 306      -77.97   -108.72
REMARK 500    VAL B 367       77.89   -117.19
REMARK 500    VAL B 407      -63.10   -123.06
REMARK 500    TYR B 449       32.47    -97.53
REMARK 500    ASN B 464       51.53   -103.90
REMARK 500    ARG B 493       76.55   -115.63
REMARK 500
REMARK 500 REMARK: NULL
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue SO4 A 607
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue SO4 A 608
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue SO4 A 609
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue SO4 A 610
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue SO4 A 611
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue SO4 A 612
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CVZ A 613
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CL A 615
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CL A 616
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CL A 617
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CL A 618
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CL A 619
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CL A 620
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CL A 622
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CL A 623
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CL A 625
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CL A 626
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CL A 627
REMARK 800
REMARK 800 SITE_IDENTIFIER: AE1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CL A 628
REMARK 800
REMARK 800 SITE_IDENTIFIER: AE2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CL A 629
REMARK 800
REMARK 800 SITE_IDENTIFIER: AE3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue SO4 B 604
REMARK 800
REMARK 800 SITE_IDENTIFIER: AE4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue SO4 B 605
REMARK 800
REMARK 800 SITE_IDENTIFIER: AE5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue SO4 B 606
REMARK 800
REMARK 800 SITE_IDENTIFIER: AE6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue SO4 B 607
REMARK 800
REMARK 800 SITE_IDENTIFIER: AE7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue SO4 B 608
REMARK 800
REMARK 800 SITE_IDENTIFIER: AE8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue SO4 B 609
REMARK 800
REMARK 800 SITE_IDENTIFIER: AE9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CVZ B 610
REMARK 800
REMARK 800 SITE_IDENTIFIER: AF1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CL B 611
REMARK 800
REMARK 800 SITE_IDENTIFIER: AF2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CL B 612
REMARK 800
REMARK 800 SITE_IDENTIFIER: AF3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CL B 613
REMARK 800
REMARK 800 SITE_IDENTIFIER: AF4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CL B 614
REMARK 800
REMARK 800 SITE_IDENTIFIER: AF5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CL B 615
REMARK 800
REMARK 800 SITE_IDENTIFIER: AF6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CL B 617
REMARK 800
REMARK 800 SITE_IDENTIFIER: AF7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CL B 618
REMARK 800
REMARK 800 SITE_IDENTIFIER: AF8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CL B 619
REMARK 800
REMARK 800 SITE_IDENTIFIER: AF9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CL B 620
REMARK 800
REMARK 800 SITE_IDENTIFIER: AG1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CL B 622
REMARK 800
REMARK 800 SITE_IDENTIFIER: AG2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CL B 623
REMARK 800
REMARK 800 SITE_IDENTIFIER: AG3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG A
REMARK 800  604 through NAG A 605 bound to ASN A 265
REMARK 800
REMARK 800 SITE_IDENTIFIER: AG4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG A
REMARK 800  601 through FUC A 603 bound to ASN A 350
REMARK 800
REMARK 800 SITE_IDENTIFIER: AG5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for Mono-Saccharide NAG A 606 bound
REMARK 800  to ASN A 464
REMARK 800
REMARK 800 SITE_IDENTIFIER: AG6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG B
REMARK 800  601 through FUC B 603 bound to ASN B 350
DBREF  6F25 A    5   543  UNP    P22303   ACES_HUMAN      36    574
DBREF  6F25 B    5   543  UNP    P22303   ACES_HUMAN      36    574
SEQRES   1 A  539  ASP ALA GLU LEU LEU VAL THR VAL ARG GLY GLY ARG LEU
SEQRES   2 A  539  ARG GLY ILE ARG LEU LYS THR PRO GLY GLY PRO VAL SER
SEQRES   3 A  539  ALA PHE LEU GLY ILE PRO PHE ALA GLU PRO PRO MET GLY
SEQRES   4 A  539  PRO ARG ARG PHE LEU PRO PRO GLU PRO LYS GLN PRO TRP
SEQRES   5 A  539  SER GLY VAL VAL ASP ALA THR THR PHE GLN SER VAL CYS
SEQRES   6 A  539  TYR GLN TYR VAL ASP THR LEU TYR PRO GLY PHE GLU GLY
SEQRES   7 A  539  THR GLU MET TRP ASN PRO ASN ARG GLU LEU SER GLU ASP
SEQRES   8 A  539  CYS LEU TYR LEU ASN VAL TRP THR PRO TYR PRO ARG PRO
SEQRES   9 A  539  THR SER PRO THR PRO VAL LEU VAL TRP ILE TYR GLY GLY
SEQRES  10 A  539  GLY PHE TYR SER GLY ALA SER SER LEU ASP VAL TYR ASP
SEQRES  11 A  539  GLY ARG PHE LEU VAL GLN ALA GLU ARG THR VAL LEU VAL
SEQRES  12 A  539  SER MET ASN TYR ARG VAL GLY ALA PHE GLY PHE LEU ALA
SEQRES  13 A  539  LEU PRO GLY SER ARG GLU ALA PRO GLY ASN VAL GLY LEU
SEQRES  14 A  539  LEU ASP GLN ARG LEU ALA LEU GLN TRP VAL GLN GLU ASN
SEQRES  15 A  539  VAL ALA ALA PHE GLY GLY ASP PRO THR SER VAL THR LEU
SEQRES  16 A  539  PHE GLY GLU SER ALA GLY ALA ALA SER VAL GLY MET HIS
SEQRES  17 A  539  LEU LEU SER PRO PRO SER ARG GLY LEU PHE HIS ARG ALA
SEQRES  18 A  539  VAL LEU GLN SER GLY ALA PRO ASN GLY PRO TRP ALA THR
SEQRES  19 A  539  VAL GLY MET GLY GLU ALA ARG ARG ARG ALA THR GLN LEU
SEQRES  20 A  539  ALA HIS LEU VAL GLY CYS PRO PRO GLY GLY THR GLY GLY
SEQRES  21 A  539  ASN ASP THR GLU LEU VAL ALA CYS LEU ARG THR ARG PRO
SEQRES  22 A  539  ALA GLN VAL LEU VAL ASN HIS GLU TRP HIS VAL LEU PRO
SEQRES  23 A  539  GLN GLU SER VAL PHE ARG PHE SER PHE VAL PRO VAL VAL
SEQRES  24 A  539  ASP GLY ASP PHE LEU SER ASP THR PRO GLU ALA LEU ILE
SEQRES  25 A  539  ASN ALA GLY ASP PHE HIS GLY LEU GLN VAL LEU VAL GLY
SEQRES  26 A  539  VAL VAL LYS ASP GLU GLY SER TYR PHE LEU VAL TYR GLY
SEQRES  27 A  539  ALA PRO GLY PHE SER LYS ASP ASN GLU SER LEU ILE SER
SEQRES  28 A  539  ARG ALA GLU PHE LEU ALA GLY VAL ARG VAL GLY VAL PRO
SEQRES  29 A  539  GLN VAL SER ASP LEU ALA ALA GLU ALA VAL VAL LEU HIS
SEQRES  30 A  539  TYR THR ASP TRP LEU HIS PRO GLU ASP PRO ALA ARG LEU
SEQRES  31 A  539  ARG GLU ALA LEU SER ASP VAL VAL GLY ASP HIS ASN VAL
SEQRES  32 A  539  VAL CYS PRO VAL ALA GLN LEU ALA GLY ARG LEU ALA ALA
SEQRES  33 A  539  GLN GLY ALA ARG VAL TYR ALA TYR VAL PHE GLU HIS ARG
SEQRES  34 A  539  ALA SER THR LEU SER TRP PRO LEU TRP MET GLY VAL PRO
SEQRES  35 A  539  HIS GLY TYR GLU ILE GLU PHE ILE PHE GLY ILE PRO LEU
SEQRES  36 A  539  ASP PRO SER ARG ASN TYR THR ALA GLU GLU LYS ILE PHE
SEQRES  37 A  539  ALA GLN ARG LEU MET ARG TYR TRP ALA ASN PHE ALA ARG
SEQRES  38 A  539  THR GLY ASP PRO ASN GLU PRO ARG ASP PRO LYS ALA PRO
SEQRES  39 A  539  GLN TRP PRO PRO TYR THR ALA GLY ALA GLN GLN TYR VAL
SEQRES  40 A  539  SER LEU ASP LEU ARG PRO LEU GLU VAL ARG ARG GLY LEU
SEQRES  41 A  539  ARG ALA GLN ALA CYS ALA PHE TRP ASN ARG PHE LEU PRO
SEQRES  42 A  539  LYS LEU LEU SER ALA THR
SEQRES   1 B  539  ASP ALA GLU LEU LEU VAL THR VAL ARG GLY GLY ARG LEU
SEQRES   2 B  539  ARG GLY ILE ARG LEU LYS THR PRO GLY GLY PRO VAL SER
SEQRES   3 B  539  ALA PHE LEU GLY ILE PRO PHE ALA GLU PRO PRO MET GLY
SEQRES   4 B  539  PRO ARG ARG PHE LEU PRO PRO GLU PRO LYS GLN PRO TRP
SEQRES   5 B  539  SER GLY VAL VAL ASP ALA THR THR PHE GLN SER VAL CYS
SEQRES   6 B  539  TYR GLN TYR VAL ASP THR LEU TYR PRO GLY PHE GLU GLY
SEQRES   7 B  539  THR GLU MET TRP ASN PRO ASN ARG GLU LEU SER GLU ASP
SEQRES   8 B  539  CYS LEU TYR LEU ASN VAL TRP THR PRO TYR PRO ARG PRO
SEQRES   9 B  539  THR SER PRO THR PRO VAL LEU VAL TRP ILE TYR GLY GLY
SEQRES  10 B  539  GLY PHE TYR SER GLY ALA SER SER LEU ASP VAL TYR ASP
SEQRES  11 B  539  GLY ARG PHE LEU VAL GLN ALA GLU ARG THR VAL LEU VAL
SEQRES  12 B  539  SER MET ASN TYR ARG VAL GLY ALA PHE GLY PHE LEU ALA
SEQRES  13 B  539  LEU PRO GLY SER ARG GLU ALA PRO GLY ASN VAL GLY LEU
SEQRES  14 B  539  LEU ASP GLN ARG LEU ALA LEU GLN TRP VAL GLN GLU ASN
SEQRES  15 B  539  VAL ALA ALA PHE GLY GLY ASP PRO THR SER VAL THR LEU
SEQRES  16 B  539  PHE GLY GLU SER ALA GLY ALA ALA SER VAL GLY MET HIS
SEQRES  17 B  539  LEU LEU SER PRO PRO SER ARG GLY LEU PHE HIS ARG ALA
SEQRES  18 B  539  VAL LEU GLN SER GLY ALA PRO ASN GLY PRO TRP ALA THR
SEQRES  19 B  539  VAL GLY MET GLY GLU ALA ARG ARG ARG ALA THR GLN LEU
SEQRES  20 B  539  ALA HIS LEU VAL GLY CYS PRO PRO GLY GLY THR GLY GLY
SEQRES  21 B  539  ASN ASP THR GLU LEU VAL ALA CYS LEU ARG THR ARG PRO
SEQRES  22 B  539  ALA GLN VAL LEU VAL ASN HIS GLU TRP HIS VAL LEU PRO
SEQRES  23 B  539  GLN GLU SER VAL PHE ARG PHE SER PHE VAL PRO VAL VAL
SEQRES  24 B  539  ASP GLY ASP PHE LEU SER ASP THR PRO GLU ALA LEU ILE
SEQRES  25 B  539  ASN ALA GLY ASP PHE HIS GLY LEU GLN VAL LEU VAL GLY
SEQRES  26 B  539  VAL VAL LYS ASP GLU GLY SER TYR PHE LEU VAL TYR GLY
SEQRES  27 B  539  ALA PRO GLY PHE SER LYS ASP ASN GLU SER LEU ILE SER
SEQRES  28 B  539  ARG ALA GLU PHE LEU ALA GLY VAL ARG VAL GLY VAL PRO
SEQRES  29 B  539  GLN VAL SER ASP LEU ALA ALA GLU ALA VAL VAL LEU HIS
SEQRES  30 B  539  TYR THR ASP TRP LEU HIS PRO GLU ASP PRO ALA ARG LEU
SEQRES  31 B  539  ARG GLU ALA LEU SER ASP VAL VAL GLY ASP HIS ASN VAL
SEQRES  32 B  539  VAL CYS PRO VAL ALA GLN LEU ALA GLY ARG LEU ALA ALA
SEQRES  33 B  539  GLN GLY ALA ARG VAL TYR ALA TYR VAL PHE GLU HIS ARG
SEQRES  34 B  539  ALA SER THR LEU SER TRP PRO LEU TRP MET GLY VAL PRO
SEQRES  35 B  539  HIS GLY TYR GLU ILE GLU PHE ILE PHE GLY ILE PRO LEU
SEQRES  36 B  539  ASP PRO SER ARG ASN TYR THR ALA GLU GLU LYS ILE PHE
SEQRES  37 B  539  ALA GLN ARG LEU MET ARG TYR TRP ALA ASN PHE ALA ARG
SEQRES  38 B  539  THR GLY ASP PRO ASN GLU PRO ARG ASP PRO LYS ALA PRO
SEQRES  39 B  539  GLN TRP PRO PRO TYR THR ALA GLY ALA GLN GLN TYR VAL
SEQRES  40 B  539  SER LEU ASP LEU ARG PRO LEU GLU VAL ARG ARG GLY LEU
SEQRES  41 B  539  ARG ALA GLN ALA CYS ALA PHE TRP ASN ARG PHE LEU PRO
SEQRES  42 B  539  LYS LEU LEU SER ALA THR
HET    NAG  A 601      14
HET    NAG  A 602      14
HET    FUC  A 603      10
HET    NAG  A 604      14
HET    NAG  A 605      14
HET    NAG  A 606      14
HET    SO4  A 607       5
HET    SO4  A 608       5
HET    SO4  A 609       5
HET    SO4  A 610       5
HET    SO4  A 611       5
HET    SO4  A 612       5
HET    CVZ  A 613      45
HET     CL  A 614       1
HET     CL  A 615       1
HET     CL  A 616       1
HET     CL  A 617       1
HET     CL  A 618       1
HET     CL  A 619       1
HET     CL  A 620       1
HET     CL  A 621       1
HET     CL  A 622       1
HET     CL  A 623       1
HET     CL  A 624       1
HET     CL  A 625       1
HET     CL  A 626       1
HET     CL  A 627       1
HET     CL  A 628       1
HET     CL  A 629       1
HET    NAG  B 601      14
HET    NAG  B 602      14
HET    FUC  B 603      10
HET    SO4  B 604       5
HET    SO4  B 605       5
HET    SO4  B 606       5
HET    SO4  B 607       5
HET    SO4  B 608       5
HET    SO4  B 609       5
HET    CVZ  B 610      45
HET     CL  B 611       1
HET     CL  B 612       1
HET     CL  B 613       1
HET     CL  B 614       1
HET     CL  B 615       1
HET     CL  B 616       1
HET     CL  B 617       1
HET     CL  B 618       1
HET     CL  B 619       1
HET     CL  B 620       1
HET     CL  B 621       1
HET     CL  B 622       1
HET     CL  B 623       1
HETNAM     NAG N-ACETYL-D-GLUCOSAMINE
HETNAM     FUC ALPHA-L-FUCOSE
HETNAM     SO4 SULFATE ION
HETNAM     CVZ 3-[(~{E})-5-[ETHYL-[(2-NITROPHENYL)METHYL]AMINO]PENT-1-
HETNAM   2 CVZ  ENYL]-1-[5-[ETHYL-[(2-NITROPHENYL)
HETNAM   3 CVZ  METHYL]AMINO]PENTYL]-6-METHYL-PYRIMIDINE-2,4-DIONE
HETNAM      CL CHLORIDE ION
FORMUL   3  NAG    7(C8 H15 N O6)
FORMUL   3  FUC    2(C6 H12 O5)
FORMUL   6  SO4    12(O4 S 2-)
FORMUL  12  CVZ    2(C33 H44 N6 O6)
FORMUL  13   CL    29(CL 1-)
FORMUL  50  HOH   *205(H2 O)
HELIX    1 AA1 MET A   42  ARG A   46  5                                   5
HELIX    2 AA2 PHE A   80  MET A   85  1                                   6
HELIX    3 AA3 LEU A  130  ASP A  134  5                                   5
HELIX    4 AA4 GLY A  135  ARG A  143  1                                   9
HELIX    5 AA5 GLY A  154  LEU A  159  1                                   6
HELIX    6 AA6 ASN A  170  VAL A  187  1                                  18
HELIX    7 AA7 ALA A  188  PHE A  190  5                                   3
HELIX    8 AA8 SER A  203  SER A  215  1                                  13
HELIX    9 AA9 SER A  215  GLY A  220  1                                   6
HELIX   10 AB1 MET A  241  VAL A  255  1                                  15
HELIX   11 AB2 ASP A  266  ARG A  274  1                                   9
HELIX   12 AB3 PRO A  277  ASN A  283  1                                   7
HELIX   13 AB4 HIS A  284  LEU A  289  5                                   6
HELIX   14 AB5 THR A  311  GLY A  319  1                                   9
HELIX   15 AB6 PHE A  338  GLY A  342  5                                   5
HELIX   16 AB7 SER A  355  VAL A  367  1                                  13
HELIX   17 AB8 SER A  371  THR A  383  1                                  13
HELIX   18 AB9 ASP A  390  VAL A  407  1                                  18
HELIX   19 AC1 VAL A  407  ALA A  420  1                                  14
HELIX   20 AC2 PRO A  440  GLY A  444  5                                   5
HELIX   21 AC3 GLU A  450  PHE A  455  1                                   6
HELIX   22 AC4 GLY A  456  ASP A  460  5                                   5
HELIX   23 AC5 THR A  466  GLY A  487  1                                  22
HELIX   24 AC6 ARG A  525  ARG A  534  1                                  10
HELIX   25 AC7 ARG A  534  SER A  541  1                                   8
HELIX   26 AC8 MET B   42  ARG B   46  5                                   5
HELIX   27 AC9 PHE B   80  MET B   85  1                                   6
HELIX   28 AD1 LEU B  130  ASP B  134  5                                   5
HELIX   29 AD2 GLY B  135  ARG B  143  1                                   9
HELIX   30 AD3 VAL B  153  LEU B  159  1                                   7
HELIX   31 AD4 ASN B  170  VAL B  187  1                                  18
HELIX   32 AD5 ALA B  188  PHE B  190  5                                   3
HELIX   33 AD6 SER B  203  SER B  215  1                                  13
HELIX   34 AD7 SER B  215  GLY B  220  1                                   6
HELIX   35 AD8 MET B  241  VAL B  255  1                                  15
HELIX   36 AD9 ASN B  265  ARG B  274  1                                  10
HELIX   37 AE1 PRO B  277  HIS B  284  1                                   8
HELIX   38 AE2 GLU B  285  LEU B  289  5                                   5
HELIX   39 AE3 THR B  311  ALA B  318  1                                   8
HELIX   40 AE4 SER B  336  GLY B  342  5                                   7
HELIX   41 AE5 SER B  355  VAL B  367  1                                  13
HELIX   42 AE6 SER B  371  THR B  383  1                                  13
HELIX   43 AE7 ASP B  390  VAL B  407  1                                  18
HELIX   44 AE8 VAL B  407  GLN B  421  1                                  15
HELIX   45 AE9 PRO B  440  GLY B  444  5                                   5
HELIX   46 AF1 GLU B  450  PHE B  455  1                                   6
HELIX   47 AF2 GLY B  456  ASP B  460  5                                   5
HELIX   48 AF3 THR B  466  GLY B  487  1                                  22
HELIX   49 AF4 ARG B  525  ARG B  534  1                                  10
HELIX   50 AF5 ARG B  534  SER B  541  1                                   8
SHEET    1 AA1 3 LEU A   9  VAL A  12  0
SHEET    2 AA1 3 GLY A  15  ARG A  18 -1  O  LEU A  17   N  VAL A  10
SHEET    3 AA1 3 VAL A  59  ASP A  61  1  O  VAL A  60   N  ARG A  16
SHEET    1 AA211 ILE A  20  THR A  24  0
SHEET    2 AA211 GLY A  27  PRO A  36 -1  O  VAL A  29   N  LEU A  22
SHEET    3 AA211 TYR A  98  PRO A 104 -1  O  LEU A  99   N  ILE A  35
SHEET    4 AA211 VAL A 145  MET A 149 -1  O  LEU A 146   N  TRP A 102
SHEET    5 AA211 THR A 112  ILE A 118  1  N  TRP A 117   O  VAL A 147
SHEET    6 AA211 GLY A 192  GLU A 202  1  O  SER A 196   N  VAL A 114
SHEET    7 AA211 ARG A 224  GLN A 228  1  O  GLN A 228   N  GLY A 201
SHEET    8 AA211 GLN A 325  VAL A 331  1  O  LEU A 327   N  LEU A 227
SHEET    9 AA211 ARG A 424  PHE A 430  1  O  ARG A 424   N  VAL A 326
SHEET   10 AA211 GLN A 509  LEU A 513  1  O  VAL A 511   N  VAL A 429
SHEET   11 AA211 GLU A 519  ARG A 522 -1  O  ARG A 521   N  TYR A 510
SHEET    1 AA3 2 VAL A 239  GLY A 240  0
SHEET    2 AA3 2 VAL A 302  VAL A 303  1  O  VAL A 303   N  VAL A 239
SHEET    1 AA4 3 LEU B   9  VAL B  12  0
SHEET    2 AA4 3 GLY B  15  ARG B  18 -1  O  GLY B  15   N  VAL B  12
SHEET    3 AA4 3 VAL B  59  ASP B  61  1  O  VAL B  60   N  ARG B  18
SHEET    1 AA511 ILE B  20  THR B  24  0
SHEET    2 AA511 GLY B  27  PRO B  36 -1  O  VAL B  29   N  LEU B  22
SHEET    3 AA511 TYR B  98  PRO B 104 -1  O  LEU B  99   N  ILE B  35
SHEET    4 AA511 VAL B 145  MET B 149 -1  O  LEU B 146   N  TRP B 102
SHEET    5 AA511 THR B 112  ILE B 118  1  N  LEU B 115   O  VAL B 145
SHEET    6 AA511 GLY B 192  GLU B 202  1  O  THR B 198   N  VAL B 114
SHEET    7 AA511 ARG B 224  GLN B 228  1  O  VAL B 226   N  LEU B 199
SHEET    8 AA511 LEU B 324  VAL B 331  1  O  LEU B 327   N  LEU B 227
SHEET    9 AA511 ALA B 423  PHE B 430  1  O  PHE B 430   N  VAL B 330
SHEET   10 AA511 GLN B 509  LEU B 513  1  O  LEU B 513   N  VAL B 429
SHEET   11 AA511 GLU B 519  ARG B 522 -1  O  ARG B 521   N  TYR B 510
SHEET    1 AA6 2 VAL B 239  GLY B 240  0
SHEET    2 AA6 2 VAL B 302  VAL B 303  1  O  VAL B 303   N  VAL B 239
SSBOND   1 CYS A   69    CYS A   96                          1555   1555  2.03
SSBOND   2 CYS A  257    CYS A  272                          1555   1555  2.03
SSBOND   3 CYS A  409    CYS A  529                          1555   1555  2.03
SSBOND   4 CYS B   69    CYS B   96                          1555   1555  2.03
SSBOND   5 CYS B  257    CYS B  272                          1555   1555  2.03
SSBOND   6 CYS B  409    CYS B  529                          1555   1555  2.03
LINK         ND2 ASN A 265                 C1  NAG A 604     1555   1555  1.44
LINK         ND2 ASN A 350                 C1  NAG A 601     1555   1555  1.44
LINK         ND2 ASN A 464                 C1  NAG A 606     1555   1555  1.44
LINK         ND2 ASN B 350                 C1  NAG B 601     1555   1555  1.45
LINK         O4  NAG A 601                 C1  NAG A 602     1555   1555  1.45
LINK         O6  NAG A 601                 C1  FUC A 603     1555   1555  1.45
LINK         O3  NAG A 604                 C1  NAG A 605     1555   1555  1.46
LINK         O4  NAG B 601                 C1  NAG B 602     1555   1555  1.44
LINK         O6  NAG B 601                 C1  FUC B 603     1555   1555  1.44
SITE     1 AC1  2 THR A 466  ALA A 467
SITE     1 AC2  3 GLN A 413  ARG A 417  HOH A 763
SITE     1 AC3  3 ARG A 356  LEU A 360  ARG B 534
SITE     1 AC4  3 THR A 504  GLY A 506  ALA A 507
SITE     1 AC5  3 HIS A 322  HOH A 756  ARG B 276
SITE     1 AC6  2 MET A 241  GLY A 242
SITE     1 AC7 10 TRP A  86  TYR A 124  GLU A 202  SER A 203
SITE     2 AC7 10 TRP A 286  HIS A 287  PHE A 295  TYR A 337
SITE     3 AC7 10 PHE A 338  HIS A 447
SITE     1 AC8  2 ARG A 424  ARG B 276
SITE     1 AC9  1 LEU A 441
SITE     1 AD1  2 ARG A  16  GLY A  58
SITE     1 AD2  1 ARG A 143
SITE     1 AD3  1 ASP A 372
SITE     1 AD4  1 ARG A 136
SITE     1 AD5  1 ARG A 393
SITE     1 AD6  2 ARG A 534  LYS A 538
SITE     1 AD7  2 PRO A 312  GLU A 313
SITE     1 AD8  2 ARG A 165  THR A 267
SITE     1 AD9  1 ARG A 417
SITE     1 AE1  1 ARG A 522
SITE     1 AE2  2 GLN A 527  ALA A 528
SITE     1 AE3  3 THR B 504  GLY B 506  ALA B 507
SITE     1 AE4  5 ARG A 534  ARG B 356  LEU B 360  TRP B 385
SITE     2 AE4  5 HOH B 706
SITE     1 AE5  1 ARG B 478
SITE     1 AE6  4 GLY B 240  MET B 241  GLY B 242  HOH B 730
SITE     1 AE7  3 GLN B 413  ARG B 417  HOH B 739
SITE     1 AE8  2 PRO B 108  THR B 109
SITE     1 AE9 18 PRO A 492  ARG A 493  PRO A 495  LYS A 496
SITE     2 AE9 18 TRP B  86  GLY B 121  TYR B 124  GLU B 202
SITE     3 AE9 18 SER B 203  TRP B 286  HIS B 287  PRO B 290
SITE     4 AE9 18 GLN B 291  GLU B 292  TYR B 337  PHE B 338
SITE     5 AE9 18 TYR B 341  HIS B 447
SITE     1 AF1  2 PRO B 162  ARG B 245
SITE     1 AF2  1 ARG B 393
SITE     1 AF3  1 ARG B 525
SITE     1 AF4  2 LYS B  23  ARG B 136
SITE     1 AF5  1 LYS B  53
SITE     1 AF6  1 ARG B 393
SITE     1 AF7  1 ARG B  16
SITE     1 AF8  1 MET A  42
SITE     1 AF9  2 GLN B 527  ALA B 528
SITE     1 AG1  2 ALA B 497  GLN B 499
SITE     1 AG2  1 GLU B 243
SITE     1 AG3  2 ASN A 265  GLU A 268
SITE     1 AG4  4 GLY A 345  PHE A 346  SER A 347  ASN A 350
SITE     1 AG5  2 SER A 462  ASN A 464
SITE     1 AG6  3 GLY B 345  SER B 347  ASN B 350
CRYST1  211.074  211.074  115.725  90.00  90.00 120.00 P 61         12
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.004738  0.002735  0.000000        0.00000
SCALE2      0.000000  0.005471  0.000000        0.00000
SCALE3      0.000000  0.000000  0.008641        0.00000
TER    4154      THR A 543
TER    8326      THR B 543
MASTER      467    0   52   50   32    0   49    6 8806    2  284   84
END