longtext: 6fvj-pdb

content
HEADER    HYDROLASE                               03-MAR-18   6FVJ
TITLE     TESA A MAJOR THIOESTERASE FROM MYCOBACTERIUM TUBERCULOSIS
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: THIOESTERASE;
COMPND   3 CHAIN: A, B, C, D, E, F, G, H;
COMPND   4 SYNONYM: THIOESTERASE TESA;
COMPND   5 EC: 6.3.2.-;
COMPND   6 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: MYCOBACTERIUM TUBERCULOSIS;
SOURCE   3 ORGANISM_TAXID: 1773;
SOURCE   4 GENE: MBTB_1, MBTB_2;
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 562
KEYWDS    TESA, THIOESTERASE, MYCOBACTERIUM TUBERCULOSIS, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    C.CAMBILLAU,V.S.NGUYEN,S.CANAAN
REVDAT   1   24-OCT-18 6FVJ    0
JRNL        AUTH   P.C.NGUYEN,V.S.NGUYEN,B.P.MARTIN,P.FOURQUET,L.CAMOIN,
JRNL        AUTH 2 C.D.SPILLING,J.F.CAVALIER,C.CAMBILLAU,S.CANAAN
JRNL        TITL   BIOCHEMICAL AND STRUCTURAL CHARACTERIZATION OF TESA, A MAJOR
JRNL        TITL 2 THIOESTERASE REQUIRED FOR OUTER-ENVELOPE LIPID BIOSYNTHESIS
JRNL        TITL 3 IN MYCOBACTERIUM TUBERCULOSIS.
JRNL        REF    J. MOL. BIOL.                              2018
JRNL        REFN                   ESSN 1089-8638
JRNL        PMID   30292819
JRNL        DOI    10.1016/J.JMB.2018.09.017
REMARK   2
REMARK   2 RESOLUTION.    2.60 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : BUSTER 2.10.3
REMARK   3   AUTHORS     : BRICOGNE,BLANC,BRANDL,FLENSBURG,KELLER,
REMARK   3               : PACIOREK,ROVERSI,SHARFF,SMART,VONRHEIN,
REMARK   3               : WOMACK,MATTHEWS,TEN EYCK,TRONRUD
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.60
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 43.83
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0.000
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.8
REMARK   3   NUMBER OF REFLECTIONS             : 61125
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD           : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION   : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET)  : 0.237
REMARK   3   R VALUE            (WORKING SET)  : 0.236
REMARK   3   FREE R VALUE                      : 0.259
REMARK   3   FREE R VALUE TEST SET SIZE   (%)  : 5.000
REMARK   3   FREE R VALUE TEST SET COUNT       : 3056
REMARK   3   ESTIMATED ERROR OF FREE R VALUE   : NULL
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED               : 20
REMARK   3   BIN RESOLUTION RANGE HIGH   (ANGSTROMS) : 2.60
REMARK   3   BIN RESOLUTION RANGE LOW    (ANGSTROMS) : 2.67
REMARK   3   BIN COMPLETENESS (WORKING+TEST)     (%) : 99.64
REMARK   3   REFLECTIONS IN BIN (WORKING + TEST SET) : 4464
REMARK   3   BIN R VALUE        (WORKING + TEST SET) : 0.2596
REMARK   3   REFLECTIONS IN BIN        (WORKING SET) : 4241
REMARK   3   BIN R VALUE               (WORKING SET) : 0.2596
REMARK   3   BIN FREE R VALUE                        : 0.2595
REMARK   3   BIN FREE R VALUE TEST SET SIZE      (%) : 5.00
REMARK   3   BIN FREE R VALUE TEST SET COUNT         : 223
REMARK   3   ESTIMATED ERROR OF BIN FREE R VALUE     : NULL
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 12935
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 148
REMARK   3   SOLVENT ATOMS            : 466
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 85.66
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 86.03
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : -1.39450
REMARK   3    B22 (A**2) : 1.56090
REMARK   3    B33 (A**2) : -0.16640
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : 0.00000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  ESTIMATED COORDINATE ERROR.
REMARK   3   ESD FROM LUZZATI PLOT                    (A) : 0.420
REMARK   3   DPI (BLOW EQ-10) BASED ON R VALUE        (A) : 0.898
REMARK   3   DPI (BLOW EQ-9) BASED ON FREE R VALUE    (A) : 0.313
REMARK   3   DPI (CRUICKSHANK) BASED ON R VALUE       (A) : 0.857
REMARK   3   DPI (CRUICKSHANK) BASED ON FREE R VALUE  (A) : 0.316
REMARK   3
REMARK   3   REFERENCES: BLOW, D. (2002) ACTA CRYST D58, 792-797
REMARK   3               CRUICKSHANK, D.W.J. (1999) ACTA CRYST D55, 583-601
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.917
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.890
REMARK   3
REMARK   3   NUMBER OF GEOMETRIC FUNCTION TERMS DEFINED : 15
REMARK   3   TERM                          COUNT    WEIGHT   FUNCTION.
REMARK   3    BOND LENGTHS              : 13427  ; 2.000  ; HARMONIC
REMARK   3    BOND ANGLES               : 18267  ; 2.000  ; HARMONIC
REMARK   3    TORSION ANGLES            : 4310   ; 2.000  ; SINUSOIDAL
REMARK   3    TRIGONAL CARBON PLANES    : NULL   ; NULL   ; NULL
REMARK   3    GENERAL PLANES            : 2252   ; 5.000  ; HARMONIC
REMARK   3    ISOTROPIC THERMAL FACTORS : 13427  ; 20.000 ; HARMONIC
REMARK   3    BAD NON-BONDED CONTACTS   : 0      ; 5.000  ; SEMIHARMONIC
REMARK   3    IMPROPER TORSIONS         : NULL   ; NULL   ; NULL
REMARK   3    PSEUDOROTATION ANGLES     : NULL   ; NULL   ; NULL
REMARK   3    CHIRAL IMPROPER TORSION   : 1767   ; 5.000  ; SEMIHARMONIC
REMARK   3    SUM OF OCCUPANCIES        : NULL   ; NULL   ; NULL
REMARK   3    UTILITY DISTANCES         : NULL   ; NULL   ; NULL
REMARK   3    UTILITY ANGLES            : NULL   ; NULL   ; NULL
REMARK   3    UTILITY TORSION           : NULL   ; NULL   ; NULL
REMARK   3    IDEAL-DIST CONTACT TERM   : 15215  ; 4.000  ; SEMIHARMONIC
REMARK   3
REMARK   3   RMS DEVIATIONS FROM IDEAL VALUES.
REMARK   3    BOND LENGTHS                       (A) : 0.009
REMARK   3    BOND ANGLES                  (DEGREES) : 1.02
REMARK   3    PEPTIDE OMEGA TORSION ANGLES (DEGREES) : 2.13
REMARK   3    OTHER TORSION ANGLES         (DEGREES) : 21.02
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : 8
REMARK   3
REMARK   3   TLS GROUP : 1
REMARK   3    SELECTION: { A|* }
REMARK   3    ORIGIN FOR THE GROUP (A):  117.5560  263.9310 -202.3050
REMARK   3    T TENSOR
REMARK   3     T11:   -0.0242 T22:    0.0053
REMARK   3     T33:    0.0069 T12:   -0.0196
REMARK   3     T13:   -0.0110 T23:    0.1431
REMARK   3    L TENSOR
REMARK   3     L11:    1.8020 L22:    1.0694
REMARK   3     L33:    0.8650 L12:    0.2015
REMARK   3     L13:    0.1297 L23:   -1.2647
REMARK   3    S TENSOR
REMARK   3     S11:   -0.0034 S12:    0.0067 S13:   -0.0015
REMARK   3     S21:   -0.0217 S22:   -0.0055 S23:    0.0394
REMARK   3     S31:   -0.0068 S32:   -0.0065 S33:    0.0089
REMARK   3
REMARK   3   TLS GROUP : 2
REMARK   3    SELECTION: { B|* }
REMARK   3    ORIGIN FOR THE GROUP (A):  156.0430  263.1630 -204.2580
REMARK   3    T TENSOR
REMARK   3     T11:   -0.0491 T22:   -0.0403
REMARK   3     T33:    0.0622 T12:   -0.0625
REMARK   3     T13:    0.0378 T23:    0.0796
REMARK   3    L TENSOR
REMARK   3     L11:    1.9978 L22:    0.7835
REMARK   3     L33:    0.6584 L12:    0.3904
REMARK   3     L13:   -0.2483 L23:   -0.6255
REMARK   3    S TENSOR
REMARK   3     S11:    0.0037 S12:    0.0136 S13:    0.0136
REMARK   3     S21:   -0.0308 S22:   -0.0058 S23:   -0.0320
REMARK   3     S31:   -0.0047 S32:    0.0040 S33:    0.0021
REMARK   3
REMARK   3   TLS GROUP : 3
REMARK   3    SELECTION: { C|* }
REMARK   3    ORIGIN FOR THE GROUP (A):  106.3910  242.9930 -182.2160
REMARK   3    T TENSOR
REMARK   3     T11:   -0.0536 T22:    0.0991
REMARK   3     T33:   -0.0835 T12:   -0.0319
REMARK   3     T13:    0.0191 T23:    0.0883
REMARK   3    L TENSOR
REMARK   3     L11:    1.8079 L22:    0.0055
REMARK   3     L33:    1.8434 L12:    0.3494
REMARK   3     L13:   -0.9254 L23:   -0.4669
REMARK   3    S TENSOR
REMARK   3     S11:   -0.0014 S12:    0.0099 S13:   -0.0073
REMARK   3     S21:    0.0017 S22:    0.0068 S23:    0.0073
REMARK   3     S31:    0.0298 S32:    0.0038 S33:   -0.0053
REMARK   3
REMARK   3   TLS GROUP : 4
REMARK   3    SELECTION: { D|* }
REMARK   3    ORIGIN FOR THE GROUP (A):  145.0030  242.2020 -184.0610
REMARK   3    T TENSOR
REMARK   3     T11:   -0.0075 T22:    0.0360
REMARK   3     T33:   -0.0536 T12:   -0.0223
REMARK   3     T13:    0.0082 T23:    0.0595
REMARK   3    L TENSOR
REMARK   3     L11:    1.4311 L22:    0.4695
REMARK   3     L33:    1.0868 L12:   -0.6489
REMARK   3     L13:   -0.0147 L23:   -0.7413
REMARK   3    S TENSOR
REMARK   3     S11:   -0.0034 S12:   -0.0193 S13:   -0.0348
REMARK   3     S21:   -0.0005 S22:   -0.0030 S23:   -0.0075
REMARK   3     S31:    0.0207 S32:    0.0156 S33:    0.0065
REMARK   3
REMARK   3   TLS GROUP : 5
REMARK   3    SELECTION: { E|* }
REMARK   3    ORIGIN FOR THE GROUP (A):  127.3250  298.1430 -204.2780
REMARK   3    T TENSOR
REMARK   3     T11:   -0.0100 T22:   -0.0640
REMARK   3     T33:   -0.0206 T12:    0.0137
REMARK   3     T13:    0.0159 T23:    0.0089
REMARK   3    L TENSOR
REMARK   3     L11:    0.0831 L22:    1.8339
REMARK   3     L33:    0.0000 L12:    1.0814
REMARK   3     L13:   -0.3336 L23:   -0.1644
REMARK   3    S TENSOR
REMARK   3     S11:    0.0026 S12:    0.0144 S13:    0.0129
REMARK   3     S21:    0.0108 S22:    0.0098 S23:   -0.0028
REMARK   3     S31:   -0.0335 S32:   -0.0003 S33:   -0.0124
REMARK   3
REMARK   3   TLS GROUP : 6
REMARK   3    SELECTION: { F|* }
REMARK   3    ORIGIN FOR THE GROUP (A):  126.2880  264.2870 -238.7320
REMARK   3    T TENSOR
REMARK   3     T11:   -0.0274 T22:   -0.0927
REMARK   3     T33:    0.0864 T12:    0.0587
REMARK   3     T13:    0.0549 T23:    0.0470
REMARK   3    L TENSOR
REMARK   3     L11:    0.5496 L22:    1.2059
REMARK   3     L33:    0.0000 L12:   -1.2977
REMARK   3     L13:    0.3278 L23:   -0.3012
REMARK   3    S TENSOR
REMARK   3     S11:   -0.0017 S12:   -0.0227 S13:    0.0203
REMARK   3     S21:    0.0006 S22:   -0.0160 S23:   -0.0482
REMARK   3     S31:    0.0097 S32:    0.0116 S33:    0.0177
REMARK   3
REMARK   3   TLS GROUP : 7
REMARK   3    SELECTION: { G|* }
REMARK   3    ORIGIN FOR THE GROUP (A):  134.4050  320.1970 -182.2430
REMARK   3    T TENSOR
REMARK   3     T11:    0.0262 T22:   -0.0406
REMARK   3     T33:   -0.0544 T12:   -0.0025
REMARK   3     T13:   -0.0378 T23:   -0.0351
REMARK   3    L TENSOR
REMARK   3     L11:    0.1365 L22:    0.2563
REMARK   3     L33:    0.2929 L12:    0.1823
REMARK   3     L13:    0.2456 L23:    1.3015
REMARK   3    S TENSOR
REMARK   3     S11:    0.0006 S12:   -0.0090 S13:   -0.0111
REMARK   3     S21:    0.0291 S22:   -0.0016 S23:   -0.0118
REMARK   3     S31:    0.0259 S32:   -0.0103 S33:    0.0010
REMARK   3
REMARK   3   TLS GROUP : 8
REMARK   3    SELECTION: { H|* }
REMARK   3    ORIGIN FOR THE GROUP (A):   93.8810  319.3070 -183.5680
REMARK   3    T TENSOR
REMARK   3     T11:   -0.0023 T22:   -0.0407
REMARK   3     T33:    0.0111 T12:   -0.0149
REMARK   3     T13:   -0.0892 T23:    0.0234
REMARK   3    L TENSOR
REMARK   3     L11:    0.0089 L22:    0.1995
REMARK   3     L33:    0.0000 L12:    0.0849
REMARK   3     L13:    1.3380 L23:   -0.4530
REMARK   3    S TENSOR
REMARK   3     S11:    0.0010 S12:    0.0003 S13:   -0.0068
REMARK   3     S21:   -0.0117 S22:    0.0017 S23:    0.0038
REMARK   3     S31:   -0.0032 S32:    0.0128 S33:   -0.0027
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 6FVJ COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 06-MAR-18.
REMARK 100 THE DEPOSITION ID IS D_1200009020.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 16-NOV-17
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 7.5
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : SOLEIL
REMARK 200  BEAMLINE                       : PROXIMA 1
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.97934
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : PIXEL
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS PILATUS3 S 6M
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200  DATA SCALING SOFTWARE          : XSCALE
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 61244
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.600
REMARK 200  RESOLUTION RANGE LOW       (A) : 43.830
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.6
REMARK 200  DATA REDUNDANCY                : 13.40
REMARK 200  R MERGE                    (I) : 0.11600
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 15.9000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.60
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.75
REMARK 200  COMPLETENESS FOR SHELL     (%) : 98.8
REMARK 200  DATA REDUNDANCY IN SHELL       : 13.50
REMARK 200  R MERGE FOR SHELL          (I) : 0.90700
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: MOLREP
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 41.77
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.11
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 45% PEG 600, 0.1 M HEPES PH 7.5, VAPOR
REMARK 280  DIFFUSION, SITTING DROP, TEMPERATURE 293K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: C 2 2 21
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,-Y,Z+1/2
REMARK 290       3555   -X,Y,-Z+1/2
REMARK 290       4555   X,-Y,-Z
REMARK 290       5555   X+1/2,Y+1/2,Z
REMARK 290       6555   -X+1/2,-Y+1/2,Z+1/2
REMARK 290       7555   -X+1/2,Y+1/2,-Z+1/2
REMARK 290       8555   X+1/2,-Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000      111.10500
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000      111.10500
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   5  1.000000  0.000000  0.000000       39.53500
REMARK 290   SMTRY2   5  0.000000  1.000000  0.000000      112.29000
REMARK 290   SMTRY3   5  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   6 -1.000000  0.000000  0.000000       39.53500
REMARK 290   SMTRY2   6  0.000000 -1.000000  0.000000      112.29000
REMARK 290   SMTRY3   6  0.000000  0.000000  1.000000      111.10500
REMARK 290   SMTRY1   7 -1.000000  0.000000  0.000000       39.53500
REMARK 290   SMTRY2   7  0.000000  1.000000  0.000000      112.29000
REMARK 290   SMTRY3   7  0.000000  0.000000 -1.000000      111.10500
REMARK 290   SMTRY1   8  1.000000  0.000000  0.000000       39.53500
REMARK 290   SMTRY2   8  0.000000 -1.000000  0.000000      112.29000
REMARK 290   SMTRY3   8  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2, 3, 4, 5, 6, 7, 8
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 3
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 4
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: D
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 5
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: E
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 6
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: F
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 7
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: G
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 8
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: H
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 375
REMARK 375 SPECIAL POSITION
REMARK 375 THE FOLLOWING ATOMS ARE FOUND TO BE WITHIN 0.15 ANGSTROMS
REMARK 375 OF A SYMMETRY RELATED ATOM AND ARE ASSUMED TO BE ON SPECIAL
REMARK 375 POSITIONS.
REMARK 375
REMARK 375 ATOM RES CSSEQI
REMARK 375      HOH D 478  LIES ON A SPECIAL POSITION.
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A     1
REMARK 465     LEU A     2
REMARK 465     ALA A     3
REMARK 465     ARG A     4
REMARK 465     HIS A     5
REMARK 465     GLY A     6
REMARK 465     PRO A     7
REMARK 465     ARG A     8
REMARK 465     TYR A     9
REMARK 465     GLY A    10
REMARK 465     GLY A    11
REMARK 465     SER A    12
REMARK 465     VAL A    13
REMARK 465     ASN A    14
REMARK 465     GLY A    15
REMARK 465     HIS A    16
REMARK 465     SER A    17
REMARK 465     ASP A    18
REMARK 465     ASP A    19
REMARK 465     SER A    20
REMARK 465     SER A    21
REMARK 465     GLY A    22
REMARK 465     ASP A    23
REMARK 465     ALA A    24
REMARK 465     LYS A    25
REMARK 465     GLN A    26
REMARK 465     GLN A    65
REMARK 465     HIS A    66
REMARK 465     ASP A    67
REMARK 465     ARG A    68
REMARK 465     SER A    69
REMARK 465     GLY A    70
REMARK 465     LEU A    71
REMARK 465     PRO A    72
REMARK 465     THR A   156
REMARK 465     ARG A   157
REMARK 465     MET A   158
REMARK 465     THR A   159
REMARK 465     GLY A   160
REMARK 465     MET A   161
REMARK 465     ASN A   162
REMARK 465     PRO A   163
REMARK 465     ASP A   164
REMARK 465     PHE A   165
REMARK 465     PHE A   166
REMARK 465     THR A   167
REMARK 465     ASP A   168
REMARK 465     ASP A   169
REMARK 465     GLU A   170
REMARK 465     PHE A   171
REMARK 465     ARG A   260
REMARK 465     ALA A   261
REMARK 465     MET B     1
REMARK 465     LEU B     2
REMARK 465     ALA B     3
REMARK 465     ARG B     4
REMARK 465     HIS B     5
REMARK 465     GLY B     6
REMARK 465     PRO B     7
REMARK 465     ARG B     8
REMARK 465     TYR B     9
REMARK 465     GLY B    10
REMARK 465     GLY B    11
REMARK 465     SER B    12
REMARK 465     VAL B    13
REMARK 465     ASN B    14
REMARK 465     GLY B    15
REMARK 465     HIS B    16
REMARK 465     SER B    17
REMARK 465     ASP B    18
REMARK 465     ASP B    19
REMARK 465     SER B    20
REMARK 465     SER B    21
REMARK 465     GLY B    22
REMARK 465     ASP B    23
REMARK 465     ALA B    24
REMARK 465     LYS B    25
REMARK 465     GLN B    26
REMARK 465     GLN B    65
REMARK 465     HIS B    66
REMARK 465     ASP B    67
REMARK 465     ARG B    68
REMARK 465     SER B    69
REMARK 465     GLY B    70
REMARK 465     LEU B    71
REMARK 465     PRO B    72
REMARK 465     PRO B    73
REMARK 465     THR B   159
REMARK 465     GLY B   160
REMARK 465     MET B   161
REMARK 465     ASN B   162
REMARK 465     PRO B   163
REMARK 465     ASP B   164
REMARK 465     PHE B   165
REMARK 465     PHE B   166
REMARK 465     THR B   167
REMARK 465     ASP B   168
REMARK 465     ASP B   169
REMARK 465     GLU B   170
REMARK 465     PHE B   171
REMARK 465     ALA B   261
REMARK 465     MET C     1
REMARK 465     LEU C     2
REMARK 465     ALA C     3
REMARK 465     ARG C     4
REMARK 465     HIS C     5
REMARK 465     GLY C     6
REMARK 465     PRO C     7
REMARK 465     ARG C     8
REMARK 465     TYR C     9
REMARK 465     GLY C    10
REMARK 465     GLY C    11
REMARK 465     SER C    12
REMARK 465     VAL C    13
REMARK 465     ASN C    14
REMARK 465     GLY C    15
REMARK 465     HIS C    16
REMARK 465     SER C    17
REMARK 465     ASP C    18
REMARK 465     ASP C    19
REMARK 465     SER C    20
REMARK 465     SER C    21
REMARK 465     GLY C    22
REMARK 465     ASP C    23
REMARK 465     ALA C    24
REMARK 465     LYS C    25
REMARK 465     GLN C    26
REMARK 465     ALA C    27
REMARK 465     GLN C    65
REMARK 465     HIS C    66
REMARK 465     ASP C    67
REMARK 465     ARG C    68
REMARK 465     SER C    69
REMARK 465     GLY C    70
REMARK 465     LEU C    71
REMARK 465     PRO C    72
REMARK 465     PRO C    73
REMARK 465     ARG C   157
REMARK 465     MET C   158
REMARK 465     THR C   159
REMARK 465     GLY C   160
REMARK 465     MET C   161
REMARK 465     ASN C   162
REMARK 465     PRO C   163
REMARK 465     ASP C   164
REMARK 465     PHE C   165
REMARK 465     PHE C   166
REMARK 465     THR C   167
REMARK 465     ASP C   168
REMARK 465     ASP C   169
REMARK 465     GLU C   170
REMARK 465     PHE C   171
REMARK 465     PHE C   172
REMARK 465     VAL C   173
REMARK 465     ASP C   259
REMARK 465     ARG C   260
REMARK 465     ALA C   261
REMARK 465     MET D     1
REMARK 465     LEU D     2
REMARK 465     ALA D     3
REMARK 465     ARG D     4
REMARK 465     HIS D     5
REMARK 465     GLY D     6
REMARK 465     PRO D     7
REMARK 465     ARG D     8
REMARK 465     TYR D     9
REMARK 465     GLY D    10
REMARK 465     GLY D    11
REMARK 465     SER D    12
REMARK 465     VAL D    13
REMARK 465     ASN D    14
REMARK 465     GLY D    15
REMARK 465     HIS D    16
REMARK 465     SER D    17
REMARK 465     ASP D    18
REMARK 465     ASP D    19
REMARK 465     SER D    20
REMARK 465     SER D    21
REMARK 465     GLY D    22
REMARK 465     ASP D    23
REMARK 465     GLN D    65
REMARK 465     HIS D    66
REMARK 465     ASP D    67
REMARK 465     ARG D    68
REMARK 465     SER D    69
REMARK 465     THR D   159
REMARK 465     GLY D   160
REMARK 465     MET D   161
REMARK 465     ASN D   162
REMARK 465     PRO D   163
REMARK 465     ASP D   164
REMARK 465     PHE D   165
REMARK 465     PHE D   166
REMARK 465     THR D   167
REMARK 465     ALA D   261
REMARK 465     MET E     1
REMARK 465     LEU E     2
REMARK 465     ALA E     3
REMARK 465     ARG E     4
REMARK 465     HIS E     5
REMARK 465     GLY E     6
REMARK 465     PRO E     7
REMARK 465     ARG E     8
REMARK 465     TYR E     9
REMARK 465     GLY E    10
REMARK 465     GLY E    11
REMARK 465     SER E    12
REMARK 465     VAL E    13
REMARK 465     ASN E    14
REMARK 465     GLY E    15
REMARK 465     HIS E    16
REMARK 465     SER E    17
REMARK 465     ASP E    18
REMARK 465     ASP E    19
REMARK 465     SER E    20
REMARK 465     SER E    21
REMARK 465     GLY E    22
REMARK 465     ASP E    23
REMARK 465     ALA E    24
REMARK 465     LYS E    25
REMARK 465     GLN E    26
REMARK 465     ALA E    27
REMARK 465     GLN E    65
REMARK 465     HIS E    66
REMARK 465     ASP E    67
REMARK 465     ARG E    68
REMARK 465     SER E    69
REMARK 465     GLY E    70
REMARK 465     THR E   159
REMARK 465     GLY E   160
REMARK 465     MET E   161
REMARK 465     ASN E   162
REMARK 465     PRO E   163
REMARK 465     ASP E   164
REMARK 465     PHE E   165
REMARK 465     PHE E   166
REMARK 465     THR E   167
REMARK 465     ASP E   168
REMARK 465     ASP E   169
REMARK 465     GLU E   170
REMARK 465     PHE E   171
REMARK 465     ARG E   260
REMARK 465     ALA E   261
REMARK 465     MET F     1
REMARK 465     LEU F     2
REMARK 465     ALA F     3
REMARK 465     ARG F     4
REMARK 465     HIS F     5
REMARK 465     GLY F     6
REMARK 465     PRO F     7
REMARK 465     ARG F     8
REMARK 465     TYR F     9
REMARK 465     GLY F    10
REMARK 465     GLY F    11
REMARK 465     SER F    12
REMARK 465     VAL F    13
REMARK 465     ASN F    14
REMARK 465     GLY F    15
REMARK 465     HIS F    16
REMARK 465     SER F    17
REMARK 465     ASP F    18
REMARK 465     ASP F    19
REMARK 465     SER F    20
REMARK 465     SER F    21
REMARK 465     GLY F    22
REMARK 465     ASP F    23
REMARK 465     ALA F    24
REMARK 465     LYS F    25
REMARK 465     GLN F    26
REMARK 465     GLN F    65
REMARK 465     HIS F    66
REMARK 465     ASP F    67
REMARK 465     ARG F    68
REMARK 465     SER F    69
REMARK 465     GLY F    70
REMARK 465     LEU F    71
REMARK 465     PRO F    72
REMARK 465     PRO F    73
REMARK 465     ARG F   157
REMARK 465     MET F   158
REMARK 465     THR F   159
REMARK 465     GLY F   160
REMARK 465     MET F   161
REMARK 465     ASN F   162
REMARK 465     PRO F   163
REMARK 465     ASP F   164
REMARK 465     PHE F   165
REMARK 465     PHE F   166
REMARK 465     THR F   167
REMARK 465     ASP F   168
REMARK 465     ASP F   169
REMARK 465     GLU F   170
REMARK 465     PHE F   171
REMARK 465     ASP F   259
REMARK 465     ARG F   260
REMARK 465     ALA F   261
REMARK 465     MET G     1
REMARK 465     LEU G     2
REMARK 465     ALA G     3
REMARK 465     ARG G     4
REMARK 465     HIS G     5
REMARK 465     GLY G     6
REMARK 465     PRO G     7
REMARK 465     ARG G     8
REMARK 465     TYR G     9
REMARK 465     GLY G    10
REMARK 465     GLY G    11
REMARK 465     SER G    12
REMARK 465     VAL G    13
REMARK 465     ASN G    14
REMARK 465     GLY G    15
REMARK 465     HIS G    16
REMARK 465     SER G    17
REMARK 465     ASP G    18
REMARK 465     ASP G    19
REMARK 465     SER G    20
REMARK 465     SER G    21
REMARK 465     GLY G    22
REMARK 465     ASP G    23
REMARK 465     ALA G    24
REMARK 465     LYS G    25
REMARK 465     GLN G    26
REMARK 465     ALA G    27
REMARK 465     GLN G    65
REMARK 465     HIS G    66
REMARK 465     ASP G    67
REMARK 465     ARG G    68
REMARK 465     SER G    69
REMARK 465     GLY G    70
REMARK 465     LEU G    71
REMARK 465     PRO G    72
REMARK 465     PRO G    73
REMARK 465     THR G   156
REMARK 465     ARG G   157
REMARK 465     MET G   158
REMARK 465     THR G   159
REMARK 465     GLY G   160
REMARK 465     MET G   161
REMARK 465     ASN G   162
REMARK 465     PRO G   163
REMARK 465     ASP G   164
REMARK 465     PHE G   165
REMARK 465     PHE G   166
REMARK 465     THR G   167
REMARK 465     ASP G   168
REMARK 465     ASP G   169
REMARK 465     GLU G   170
REMARK 465     PHE G   171
REMARK 465     PHE G   172
REMARK 465     ARG G   260
REMARK 465     ALA G   261
REMARK 465     MET H     1
REMARK 465     LEU H     2
REMARK 465     ALA H     3
REMARK 465     ARG H     4
REMARK 465     HIS H     5
REMARK 465     GLY H     6
REMARK 465     PRO H     7
REMARK 465     ARG H     8
REMARK 465     TYR H     9
REMARK 465     GLY H    10
REMARK 465     GLY H    11
REMARK 465     SER H    12
REMARK 465     VAL H    13
REMARK 465     ASN H    14
REMARK 465     GLY H    15
REMARK 465     HIS H    16
REMARK 465     SER H    17
REMARK 465     ASP H    18
REMARK 465     ASP H    19
REMARK 465     SER H    20
REMARK 465     SER H    21
REMARK 465     GLY H    22
REMARK 465     ASP H    23
REMARK 465     ALA H    24
REMARK 465     LYS H    25
REMARK 465     GLN H    26
REMARK 465     ALA H    27
REMARK 465     GLN H    65
REMARK 465     HIS H    66
REMARK 465     ASP H    67
REMARK 465     ARG H    68
REMARK 465     SER H    69
REMARK 465     GLY H    70
REMARK 465     LEU H    71
REMARK 465     PRO H    72
REMARK 465     PRO H    73
REMARK 465     LEU H    74
REMARK 465     GLU H    75
REMARK 465     ARG H   157
REMARK 465     MET H   158
REMARK 465     THR H   159
REMARK 465     GLY H   160
REMARK 465     MET H   161
REMARK 465     ASN H   162
REMARK 465     PRO H   163
REMARK 465     ASP H   164
REMARK 465     PHE H   165
REMARK 465     PHE H   166
REMARK 465     THR H   167
REMARK 465     ASP H   168
REMARK 465     ASP H   169
REMARK 465     GLU H   170
REMARK 465     PHE H   171
REMARK 465     PHE H   172
REMARK 465     ARG H   260
REMARK 465     ALA H   261
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     LYS A  56    CG   CD   CE   NZ
REMARK 470     LYS A 141    CG   CD   CE   NZ
REMARK 470     GLN A 142    CG   CD   OE1  NE2
REMARK 470     GLN A 144    CG   CD   OE1  NE2
REMARK 470     ASP A 145    CG   OD1  OD2
REMARK 470     LEU A 146    CG   CD1  CD2
REMARK 470     GLU A 150    CG   CD   OE1  OE2
REMARK 470     MET A 151    CG   SD   CE
REMARK 470     ASP A 153    CG   OD1  OD2
REMARK 470     PHE A 155    CG   CD1  CD2  CE1  CE2  CZ
REMARK 470     PHE A 172    CG   CD1  CD2  CE1  CE2  CZ
REMARK 470     ARG A 180    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ASP A 252    CG   OD1  OD2
REMARK 470     ASP A 259    CG   OD1  OD2
REMARK 470     LYS B  42    CD   CE   NZ
REMARK 470     LEU B  74    CG   CD1  CD2
REMARK 470     LYS B 141    CG   CD   CE   NZ
REMARK 470     LEU B 143    CG   CD1  CD2
REMARK 470     GLN B 144    CG   CD   OE1  NE2
REMARK 470     LEU B 146    CG   CD1  CD2
REMARK 470     GLU B 150    CG   CD   OE1  OE2
REMARK 470     LEU B 154    CG   CD1  CD2
REMARK 470     PHE B 155    CG   CD1  CD2  CE1  CE2  CZ
REMARK 470     THR B 156    OG1  CG2
REMARK 470     ARG B 157    CG   CD   NE   CZ   NH1  NH2
REMARK 470     MET B 158    CG   SD   CE
REMARK 470     PHE B 172    CG   CD1  CD2  CE1  CE2  CZ
REMARK 470     LEU B 176    CG   CD1  CD2
REMARK 470     ASP B 214    CG   OD1  OD2
REMARK 470     LYS C  42    CG   CD   CE   NZ
REMARK 470     ARG C 123    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ARG C 139    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ASP C 153    CG   OD1  OD2
REMARK 470     PHE C 155    CG   CD1  CD2  CE1  CE2  CZ
REMARK 470     THR C 156    OG1  CG2
REMARK 470     ARG C 180    CG   CD   NE   CZ   NH1  NH2
REMARK 470     LYS D  42    CD   CE   NZ
REMARK 470     LEU D  71    CG   CD1  CD2
REMARK 470     ASP D  95    CG   OD1  OD2
REMARK 470     ARG D 139    CG   CD   NE   CZ   NH1  NH2
REMARK 470     TYR D 140    CG   CD1  CD2  CE1  CE2  CZ   OH
REMARK 470     LYS D 141    CG   CD   CE   NZ
REMARK 470     GLN D 144    CG   CD   OE1  NE2
REMARK 470     ARG D 149    CZ   NH1  NH2
REMARK 470     MET D 151    CG   SD   CE
REMARK 470     PHE D 155    CD2  CE1  CE2  CZ
REMARK 470     MET D 158    CG   SD   CE
REMARK 470     ASP D 168    CG   OD1  OD2
REMARK 470     ASP D 169    CG   OD1  OD2
REMARK 470     GLU D 170    CG   CD   OE1  OE2
REMARK 470     PHE D 171    CG   CD1  CD2  CE1  CE2  CZ
REMARK 470     PHE D 172    CG   CD1  CD2  CE1  CE2  CZ
REMARK 470     VAL D 173    CG1  CG2
REMARK 470     ARG D 260    CG   CD   NE   CZ   NH1  NH2
REMARK 470     LYS E  42    CD   CE   NZ
REMARK 470     ILE E 138    CG1  CG2  CD1
REMARK 470     ARG E 139    CG   CD   NE   CZ   NH1  NH2
REMARK 470     GLN E 144    CG   CD   OE1  NE2
REMARK 470     ASP E 148    CG   OD1  OD2
REMARK 470     ARG E 149    CG   CD   NE   CZ   NH1  NH2
REMARK 470     MET E 158    CG   SD   CE
REMARK 470     PHE E 172    CG   CD1  CD2  CE1  CE2  CZ
REMARK 470     VAL E 173    CG1  CG2
REMARK 470     ASP E 259    CG   OD1  OD2
REMARK 470     LYS F  42    CD   CE   NZ
REMARK 470     LEU F  74    CG   CD1  CD2
REMARK 470     LEU F 146    CG   CD1  CD2
REMARK 470     PHE F 155    CG   CD1  CD2  CE1  CE2  CZ
REMARK 470     PHE F 172    CG   CD1  CD2  CE1  CE2  CZ
REMARK 470     VAL F 173    CG1  CG2
REMARK 470     LEU F 179    CG   CD1  CD2
REMARK 470     GLU F 193    CG   CD   OE1  OE2
REMARK 470     LYS G  42    CD   CE   NZ
REMARK 470     ASP G  54    CG   OD1  OD2
REMARK 470     GLU G  75    CG   CD   OE1  OE2
REMARK 470     ARG G 123    CG   CD   NE   CZ   NH1  NH2
REMARK 470     LEU G 146    CG   CD1  CD2
REMARK 470     GLU G 150    CG   CD   OE1  OE2
REMARK 470     MET G 151    CG   SD   CE
REMARK 470     PHE G 155    CG   CD1  CD2  CE1  CE2  CZ
REMARK 470     VAL G 173    CG1  CG2
REMARK 470     ARG G 180    CG   CD   NE   CZ   NH1  NH2
REMARK 470     GLU G 193    CG   CD   OE1  OE2
REMARK 470     LYS G 195    CG   CD   CE   NZ
REMARK 470     ASN G 242    CG   OD1  ND2
REMARK 470     ASP G 259    CG   OD1  OD2
REMARK 470     LYS H  42    CG   CD   CE   NZ
REMARK 470     PHE H  51    CG   CD1  CD2  CE1  CE2  CZ
REMARK 470     LEU H 146    CG   CD1  CD2
REMARK 470     ASP H 148    CG   OD1  OD2
REMARK 470     GLU H 150    CG   CD   OE1  OE2
REMARK 470     PHE H 155    CG   CD1  CD2  CE1  CE2  CZ
REMARK 470     THR H 156    OG1  CG2
REMARK 470     VAL H 173    CG1  CG2
REMARK 470     LEU H 176    CG   CD1  CD2
REMARK 470     ARG H 180    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ASP H 259    CG   OD1  OD2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   OD2  ASP C   145     CB   ASP C   148              1.74
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    SER H 104   CA  -  CB  -  OG  ANGL. DEV. =  56.3 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    SER A 104     -118.69     56.21
REMARK 500    ALA A 131       52.44     36.44
REMARK 500    LYS A 141       47.66    -77.05
REMARK 500    ASP A 148       42.45    -92.13
REMARK 500    ARG A 149        4.50    -63.57
REMARK 500    PRO A 218        4.57    -65.00
REMARK 500    GLU A 225     -149.06   -100.95
REMARK 500    ASP A 235     -144.64    -91.35
REMARK 500    SER B 104     -119.91     57.15
REMARK 500    ALA B 131       50.80     37.11
REMARK 500    LYS B 141       49.36    -74.88
REMARK 500    ASP B 148       33.45    -98.01
REMARK 500    PRO B 218        4.71    -65.05
REMARK 500    GLU B 225     -148.30   -102.14
REMARK 500    ASP B 235     -144.58    -91.80
REMARK 500    SER C 104     -120.44     56.88
REMARK 500    ALA C 131       50.86     36.45
REMARK 500    ILE C 138       68.21    -27.81
REMARK 500    ARG C 149       37.14    -77.13
REMARK 500    PRO C 218        4.65    -64.73
REMARK 500    GLU C 225     -147.81   -102.27
REMARK 500    ASP C 235     -145.13    -92.10
REMARK 500    ALA D  27     -144.01    -97.30
REMARK 500    LEU D  71      142.87   -174.40
REMARK 500    PRO D  73      102.87    -44.48
REMARK 500    SER D 104     -120.18     57.83
REMARK 500    ALA D 131       51.38     37.02
REMARK 500    HIS D 137       43.92    -98.58
REMARK 500    TYR D 140       48.21    -82.15
REMARK 500    GLN D 142       47.05   -107.45
REMARK 500    ASP D 169     -132.09     54.17
REMARK 500    GLU D 170      178.76     85.57
REMARK 500    PHE D 171      -24.72     89.39
REMARK 500    PRO D 218        4.86    -65.51
REMARK 500    GLU D 225     -150.18   -112.60
REMARK 500    ASP D 235     -145.03    -92.22
REMARK 500    SER E 104     -120.38     56.89
REMARK 500    ALA E 131       50.91     37.52
REMARK 500    ILE E 138     -178.32    -64.65
REMARK 500    GLN E 142       48.66   -153.35
REMARK 500    PRO E 218        5.83    -64.99
REMARK 500    GLU E 225     -153.27   -102.44
REMARK 500    ASP E 235     -145.05    -91.94
REMARK 500    SER F 104     -120.06     57.08
REMARK 500    ALA F 131       51.17     36.49
REMARK 500    HIS F 137       58.08   -104.02
REMARK 500    TYR F 140       56.50    -91.04
REMARK 500    LEU F 143     -129.23    -91.74
REMARK 500    ARG F 149       27.61   -140.45
REMARK 500    ASP F 153      -78.14    -67.69
REMARK 500
REMARK 500 THIS ENTRY HAS      67 RAMACHANDRAN OUTLIERS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 525
REMARK 525 SOLVENT
REMARK 525
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 525 NUMBER; I=INSERTION CODE):
REMARK 525
REMARK 525  M RES CSSEQI
REMARK 525    HOH A 563        DISTANCE =  6.06 ANGSTROMS
REMARK 525    HOH A 564        DISTANCE =  6.13 ANGSTROMS
REMARK 525    HOH A 565        DISTANCE =  6.17 ANGSTROMS
REMARK 525    HOH A 566        DISTANCE =  6.23 ANGSTROMS
REMARK 525    HOH A 567        DISTANCE =  7.49 ANGSTROMS
REMARK 525    HOH A 568        DISTANCE = 12.13 ANGSTROMS
REMARK 525    HOH A 569        DISTANCE = 12.75 ANGSTROMS
REMARK 525    HOH B 566        DISTANCE =  6.17 ANGSTROMS
REMARK 525    HOH B 567        DISTANCE =  6.31 ANGSTROMS
REMARK 525    HOH B 568        DISTANCE =  6.86 ANGSTROMS
REMARK 525    HOH B 569        DISTANCE =  7.54 ANGSTROMS
REMARK 525    HOH B 570        DISTANCE =  8.31 ANGSTROMS
REMARK 525    HOH B 571        DISTANCE =  9.04 ANGSTROMS
REMARK 525    HOH B 572        DISTANCE =  9.62 ANGSTROMS
REMARK 525    HOH C 457        DISTANCE =  6.52 ANGSTROMS
REMARK 525    HOH C 458        DISTANCE =  6.74 ANGSTROMS
REMARK 525    HOH C 459        DISTANCE =  6.82 ANGSTROMS
REMARK 525    HOH C 460        DISTANCE =  7.23 ANGSTROMS
REMARK 525    HOH C 461        DISTANCE =  7.61 ANGSTROMS
REMARK 525    HOH C 462        DISTANCE =  8.13 ANGSTROMS
REMARK 525    HOH C 463        DISTANCE =  9.03 ANGSTROMS
REMARK 525    HOH C 464        DISTANCE =  9.09 ANGSTROMS
REMARK 525    HOH C 465        DISTANCE =  9.40 ANGSTROMS
REMARK 525    HOH C 466        DISTANCE =  9.80 ANGSTROMS
REMARK 525    HOH C 467        DISTANCE = 10.29 ANGSTROMS
REMARK 525    HOH C 468        DISTANCE = 11.44 ANGSTROMS
REMARK 525    HOH C 469        DISTANCE = 12.37 ANGSTROMS
REMARK 525    HOH C 470        DISTANCE = 13.51 ANGSTROMS
REMARK 525    HOH C 471        DISTANCE = 14.85 ANGSTROMS
REMARK 525    HOH C 472        DISTANCE = 14.94 ANGSTROMS
REMARK 525    HOH D 477        DISTANCE =  6.77 ANGSTROMS
REMARK 525    HOH D 478        DISTANCE =  9.04 ANGSTROMS
REMARK 525    HOH D 479        DISTANCE =  9.37 ANGSTROMS
REMARK 525    HOH D 480        DISTANCE =  9.54 ANGSTROMS
REMARK 525    HOH D 481        DISTANCE =  9.81 ANGSTROMS
REMARK 525    HOH D 482        DISTANCE = 13.72 ANGSTROMS
REMARK 525    HOH D 483        DISTANCE = 14.58 ANGSTROMS
REMARK 525    HOH E 445        DISTANCE =  6.43 ANGSTROMS
REMARK 525    HOH E 446        DISTANCE =  7.11 ANGSTROMS
REMARK 525    HOH E 447        DISTANCE =  7.60 ANGSTROMS
REMARK 525    HOH E 448        DISTANCE =  7.73 ANGSTROMS
REMARK 525    HOH E 449        DISTANCE =  9.41 ANGSTROMS
REMARK 525    HOH F 444        DISTANCE =  6.11 ANGSTROMS
REMARK 525    HOH F 445        DISTANCE =  6.27 ANGSTROMS
REMARK 525    HOH F 446        DISTANCE =  6.94 ANGSTROMS
REMARK 525    HOH F 447        DISTANCE =  7.89 ANGSTROMS
REMARK 525    HOH F 448        DISTANCE =  9.18 ANGSTROMS
REMARK 525    HOH F 449        DISTANCE = 11.35 ANGSTROMS
REMARK 525    HOH G 430        DISTANCE =  5.84 ANGSTROMS
REMARK 525    HOH G 431        DISTANCE =  6.10 ANGSTROMS
REMARK 525    HOH G 432        DISTANCE =  6.93 ANGSTROMS
REMARK 525    HOH G 433        DISTANCE =  7.73 ANGSTROMS
REMARK 525    HOH G 434        DISTANCE =  7.87 ANGSTROMS
REMARK 525    HOH G 435        DISTANCE =  8.35 ANGSTROMS
REMARK 525    HOH G 436        DISTANCE =  8.52 ANGSTROMS
REMARK 525    HOH H 431        DISTANCE =  6.27 ANGSTROMS
REMARK 525    HOH H 432        DISTANCE =  6.27 ANGSTROMS
REMARK 525    HOH H 433        DISTANCE =  7.06 ANGSTROMS
REMARK 525    HOH H 434        DISTANCE =  8.01 ANGSTROMS
REMARK 525    HOH H 435        DISTANCE = 10.78 ANGSTROMS
REMARK 525    HOH H 436        DISTANCE = 10.93 ANGSTROMS
REMARK 610
REMARK 610 MISSING HETEROATOM
REMARK 610 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 610 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 610 I=INSERTION CODE):
REMARK 610   M RES C SSEQI
REMARK 610     E9H A  401
REMARK 610     E9H B  401
REMARK 610     E9H C  301
REMARK 610     E9H D  301
REMARK 610     E9H E  301
REMARK 610     E9H F  301
REMARK 610     E9H G  301
REMARK 610     E9H H  301
REMARK 620
REMARK 620 METAL COORDINATION
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA A 404  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 GLU A  50   OE1
REMARK 620 2 ARG D  49   O   153.1
REMARK 620 3 PHE D  51   O    75.4  92.0
REMARK 620 N                    1     2
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA C 302  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 HOH C 409   O
REMARK 620 2 HOH B 553   O    57.8
REMARK 620 N                    1
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue E9H A 401
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue MPD A 402
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue MPD A 403
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CA A 404
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue MPD B 402
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue MPD B 403
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CA C 302
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue MPD C 303
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue MPD C 304
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue MPD D 302
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue MPD D 303
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue MPD E 302
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue MPD F 302
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue MPD F 303
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue MPD G 302
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for Di-peptide E9H B 401 and SER B
REMARK 800  104
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for Di-peptide E9H C 301 and SER C
REMARK 800  104
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for Di-peptide E9H D 301 and SER D
REMARK 800  104
REMARK 800
REMARK 800 SITE_IDENTIFIER: AE1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for Di-peptide E9H E 301 and SER E
REMARK 800  104
REMARK 800
REMARK 800 SITE_IDENTIFIER: AE2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for Di-peptide E9H F 301 and SER F
REMARK 800  104
REMARK 800
REMARK 800 SITE_IDENTIFIER: AE3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for Di-peptide E9H G 301 and SER G
REMARK 800  104
REMARK 800
REMARK 800 SITE_IDENTIFIER: AE4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for Di-peptide E9H H 301 and SER H
REMARK 800  104
DBREF1 6FVJ A    1   261  UNP                  A0A045JET3_MYCTX
DBREF2 6FVJ A     A0A045JET3                          1         261
DBREF1 6FVJ B    1   261  UNP                  A0A045JET3_MYCTX
DBREF2 6FVJ B     A0A045JET3                          1         261
DBREF1 6FVJ C    1   261  UNP                  A0A045JET3_MYCTX
DBREF2 6FVJ C     A0A045JET3                          1         261
DBREF1 6FVJ D    1   261  UNP                  A0A045JET3_MYCTX
DBREF2 6FVJ D     A0A045JET3                          1         261
DBREF1 6FVJ E    1   261  UNP                  A0A045JET3_MYCTX
DBREF2 6FVJ E     A0A045JET3                          1         261
DBREF1 6FVJ F    1   261  UNP                  A0A045JET3_MYCTX
DBREF2 6FVJ F     A0A045JET3                          1         261
DBREF1 6FVJ G    1   261  UNP                  A0A045JET3_MYCTX
DBREF2 6FVJ G     A0A045JET3                          1         261
DBREF1 6FVJ H    1   261  UNP                  A0A045JET3_MYCTX
DBREF2 6FVJ H     A0A045JET3                          1         261
SEQRES   1 A  261  MET LEU ALA ARG HIS GLY PRO ARG TYR GLY GLY SER VAL
SEQRES   2 A  261  ASN GLY HIS SER ASP ASP SER SER GLY ASP ALA LYS GLN
SEQRES   3 A  261  ALA ALA PRO THR LEU TYR ILE PHE PRO HIS ALA GLY GLY
SEQRES   4 A  261  THR ALA LYS ASP TYR VAL ALA PHE SER ARG GLU PHE SER
SEQRES   5 A  261  ALA ASP VAL LYS ARG ILE ALA VAL GLN TYR PRO GLY GLN
SEQRES   6 A  261  HIS ASP ARG SER GLY LEU PRO PRO LEU GLU SER ILE PRO
SEQRES   7 A  261  THR LEU ALA ASP GLU ILE PHE ALA MET MET LYS PRO SER
SEQRES   8 A  261  ALA ARG ILE ASP ASP PRO VAL ALA PHE PHE GLY HIS SER
SEQRES   9 A  261  MET GLY GLY MET LEU ALA PHE GLU VAL ALA LEU ARG TYR
SEQRES  10 A  261  GLN SER ALA GLY HIS ARG VAL LEU ALA PHE PHE VAL SER
SEQRES  11 A  261  ALA CYS SER ALA PRO GLY HIS ILE ARG TYR LYS GLN LEU
SEQRES  12 A  261  GLN ASP LEU SER ASP ARG GLU MET LEU ASP LEU PHE THR
SEQRES  13 A  261  ARG MET THR GLY MET ASN PRO ASP PHE PHE THR ASP ASP
SEQRES  14 A  261  GLU PHE PHE VAL GLY ALA LEU PRO THR LEU ARG ALA VAL
SEQRES  15 A  261  ARG ALA ILE ALA GLY TYR SER CYS PRO PRO GLU THR LYS
SEQRES  16 A  261  LEU SER CYS PRO ILE TYR ALA PHE ILE GLY ASP LYS ASP
SEQRES  17 A  261  TRP ILE ALA THR GLN ASP ASP MET ASP PRO TRP ARG ASP
SEQRES  18 A  261  ARG THR THR GLU GLU PHE SER ILE ARG VAL PHE PRO GLY
SEQRES  19 A  261  ASP HIS PHE TYR LEU ASN ASP ASN LEU PRO GLU LEU VAL
SEQRES  20 A  261  SER ASP ILE GLU ASP LYS THR LEU GLN TRP HIS ASP ARG
SEQRES  21 A  261  ALA
SEQRES   1 B  261  MET LEU ALA ARG HIS GLY PRO ARG TYR GLY GLY SER VAL
SEQRES   2 B  261  ASN GLY HIS SER ASP ASP SER SER GLY ASP ALA LYS GLN
SEQRES   3 B  261  ALA ALA PRO THR LEU TYR ILE PHE PRO HIS ALA GLY GLY
SEQRES   4 B  261  THR ALA LYS ASP TYR VAL ALA PHE SER ARG GLU PHE SER
SEQRES   5 B  261  ALA ASP VAL LYS ARG ILE ALA VAL GLN TYR PRO GLY GLN
SEQRES   6 B  261  HIS ASP ARG SER GLY LEU PRO PRO LEU GLU SER ILE PRO
SEQRES   7 B  261  THR LEU ALA ASP GLU ILE PHE ALA MET MET LYS PRO SER
SEQRES   8 B  261  ALA ARG ILE ASP ASP PRO VAL ALA PHE PHE GLY HIS SER
SEQRES   9 B  261  MET GLY GLY MET LEU ALA PHE GLU VAL ALA LEU ARG TYR
SEQRES  10 B  261  GLN SER ALA GLY HIS ARG VAL LEU ALA PHE PHE VAL SER
SEQRES  11 B  261  ALA CYS SER ALA PRO GLY HIS ILE ARG TYR LYS GLN LEU
SEQRES  12 B  261  GLN ASP LEU SER ASP ARG GLU MET LEU ASP LEU PHE THR
SEQRES  13 B  261  ARG MET THR GLY MET ASN PRO ASP PHE PHE THR ASP ASP
SEQRES  14 B  261  GLU PHE PHE VAL GLY ALA LEU PRO THR LEU ARG ALA VAL
SEQRES  15 B  261  ARG ALA ILE ALA GLY TYR SER CYS PRO PRO GLU THR LYS
SEQRES  16 B  261  LEU SER CYS PRO ILE TYR ALA PHE ILE GLY ASP LYS ASP
SEQRES  17 B  261  TRP ILE ALA THR GLN ASP ASP MET ASP PRO TRP ARG ASP
SEQRES  18 B  261  ARG THR THR GLU GLU PHE SER ILE ARG VAL PHE PRO GLY
SEQRES  19 B  261  ASP HIS PHE TYR LEU ASN ASP ASN LEU PRO GLU LEU VAL
SEQRES  20 B  261  SER ASP ILE GLU ASP LYS THR LEU GLN TRP HIS ASP ARG
SEQRES  21 B  261  ALA
SEQRES   1 C  261  MET LEU ALA ARG HIS GLY PRO ARG TYR GLY GLY SER VAL
SEQRES   2 C  261  ASN GLY HIS SER ASP ASP SER SER GLY ASP ALA LYS GLN
SEQRES   3 C  261  ALA ALA PRO THR LEU TYR ILE PHE PRO HIS ALA GLY GLY
SEQRES   4 C  261  THR ALA LYS ASP TYR VAL ALA PHE SER ARG GLU PHE SER
SEQRES   5 C  261  ALA ASP VAL LYS ARG ILE ALA VAL GLN TYR PRO GLY GLN
SEQRES   6 C  261  HIS ASP ARG SER GLY LEU PRO PRO LEU GLU SER ILE PRO
SEQRES   7 C  261  THR LEU ALA ASP GLU ILE PHE ALA MET MET LYS PRO SER
SEQRES   8 C  261  ALA ARG ILE ASP ASP PRO VAL ALA PHE PHE GLY HIS SER
SEQRES   9 C  261  MET GLY GLY MET LEU ALA PHE GLU VAL ALA LEU ARG TYR
SEQRES  10 C  261  GLN SER ALA GLY HIS ARG VAL LEU ALA PHE PHE VAL SER
SEQRES  11 C  261  ALA CYS SER ALA PRO GLY HIS ILE ARG TYR LYS GLN LEU
SEQRES  12 C  261  GLN ASP LEU SER ASP ARG GLU MET LEU ASP LEU PHE THR
SEQRES  13 C  261  ARG MET THR GLY MET ASN PRO ASP PHE PHE THR ASP ASP
SEQRES  14 C  261  GLU PHE PHE VAL GLY ALA LEU PRO THR LEU ARG ALA VAL
SEQRES  15 C  261  ARG ALA ILE ALA GLY TYR SER CYS PRO PRO GLU THR LYS
SEQRES  16 C  261  LEU SER CYS PRO ILE TYR ALA PHE ILE GLY ASP LYS ASP
SEQRES  17 C  261  TRP ILE ALA THR GLN ASP ASP MET ASP PRO TRP ARG ASP
SEQRES  18 C  261  ARG THR THR GLU GLU PHE SER ILE ARG VAL PHE PRO GLY
SEQRES  19 C  261  ASP HIS PHE TYR LEU ASN ASP ASN LEU PRO GLU LEU VAL
SEQRES  20 C  261  SER ASP ILE GLU ASP LYS THR LEU GLN TRP HIS ASP ARG
SEQRES  21 C  261  ALA
SEQRES   1 D  261  MET LEU ALA ARG HIS GLY PRO ARG TYR GLY GLY SER VAL
SEQRES   2 D  261  ASN GLY HIS SER ASP ASP SER SER GLY ASP ALA LYS GLN
SEQRES   3 D  261  ALA ALA PRO THR LEU TYR ILE PHE PRO HIS ALA GLY GLY
SEQRES   4 D  261  THR ALA LYS ASP TYR VAL ALA PHE SER ARG GLU PHE SER
SEQRES   5 D  261  ALA ASP VAL LYS ARG ILE ALA VAL GLN TYR PRO GLY GLN
SEQRES   6 D  261  HIS ASP ARG SER GLY LEU PRO PRO LEU GLU SER ILE PRO
SEQRES   7 D  261  THR LEU ALA ASP GLU ILE PHE ALA MET MET LYS PRO SER
SEQRES   8 D  261  ALA ARG ILE ASP ASP PRO VAL ALA PHE PHE GLY HIS SER
SEQRES   9 D  261  MET GLY GLY MET LEU ALA PHE GLU VAL ALA LEU ARG TYR
SEQRES  10 D  261  GLN SER ALA GLY HIS ARG VAL LEU ALA PHE PHE VAL SER
SEQRES  11 D  261  ALA CYS SER ALA PRO GLY HIS ILE ARG TYR LYS GLN LEU
SEQRES  12 D  261  GLN ASP LEU SER ASP ARG GLU MET LEU ASP LEU PHE THR
SEQRES  13 D  261  ARG MET THR GLY MET ASN PRO ASP PHE PHE THR ASP ASP
SEQRES  14 D  261  GLU PHE PHE VAL GLY ALA LEU PRO THR LEU ARG ALA VAL
SEQRES  15 D  261  ARG ALA ILE ALA GLY TYR SER CYS PRO PRO GLU THR LYS
SEQRES  16 D  261  LEU SER CYS PRO ILE TYR ALA PHE ILE GLY ASP LYS ASP
SEQRES  17 D  261  TRP ILE ALA THR GLN ASP ASP MET ASP PRO TRP ARG ASP
SEQRES  18 D  261  ARG THR THR GLU GLU PHE SER ILE ARG VAL PHE PRO GLY
SEQRES  19 D  261  ASP HIS PHE TYR LEU ASN ASP ASN LEU PRO GLU LEU VAL
SEQRES  20 D  261  SER ASP ILE GLU ASP LYS THR LEU GLN TRP HIS ASP ARG
SEQRES  21 D  261  ALA
SEQRES   1 E  261  MET LEU ALA ARG HIS GLY PRO ARG TYR GLY GLY SER VAL
SEQRES   2 E  261  ASN GLY HIS SER ASP ASP SER SER GLY ASP ALA LYS GLN
SEQRES   3 E  261  ALA ALA PRO THR LEU TYR ILE PHE PRO HIS ALA GLY GLY
SEQRES   4 E  261  THR ALA LYS ASP TYR VAL ALA PHE SER ARG GLU PHE SER
SEQRES   5 E  261  ALA ASP VAL LYS ARG ILE ALA VAL GLN TYR PRO GLY GLN
SEQRES   6 E  261  HIS ASP ARG SER GLY LEU PRO PRO LEU GLU SER ILE PRO
SEQRES   7 E  261  THR LEU ALA ASP GLU ILE PHE ALA MET MET LYS PRO SER
SEQRES   8 E  261  ALA ARG ILE ASP ASP PRO VAL ALA PHE PHE GLY HIS SER
SEQRES   9 E  261  MET GLY GLY MET LEU ALA PHE GLU VAL ALA LEU ARG TYR
SEQRES  10 E  261  GLN SER ALA GLY HIS ARG VAL LEU ALA PHE PHE VAL SER
SEQRES  11 E  261  ALA CYS SER ALA PRO GLY HIS ILE ARG TYR LYS GLN LEU
SEQRES  12 E  261  GLN ASP LEU SER ASP ARG GLU MET LEU ASP LEU PHE THR
SEQRES  13 E  261  ARG MET THR GLY MET ASN PRO ASP PHE PHE THR ASP ASP
SEQRES  14 E  261  GLU PHE PHE VAL GLY ALA LEU PRO THR LEU ARG ALA VAL
SEQRES  15 E  261  ARG ALA ILE ALA GLY TYR SER CYS PRO PRO GLU THR LYS
SEQRES  16 E  261  LEU SER CYS PRO ILE TYR ALA PHE ILE GLY ASP LYS ASP
SEQRES  17 E  261  TRP ILE ALA THR GLN ASP ASP MET ASP PRO TRP ARG ASP
SEQRES  18 E  261  ARG THR THR GLU GLU PHE SER ILE ARG VAL PHE PRO GLY
SEQRES  19 E  261  ASP HIS PHE TYR LEU ASN ASP ASN LEU PRO GLU LEU VAL
SEQRES  20 E  261  SER ASP ILE GLU ASP LYS THR LEU GLN TRP HIS ASP ARG
SEQRES  21 E  261  ALA
SEQRES   1 F  261  MET LEU ALA ARG HIS GLY PRO ARG TYR GLY GLY SER VAL
SEQRES   2 F  261  ASN GLY HIS SER ASP ASP SER SER GLY ASP ALA LYS GLN
SEQRES   3 F  261  ALA ALA PRO THR LEU TYR ILE PHE PRO HIS ALA GLY GLY
SEQRES   4 F  261  THR ALA LYS ASP TYR VAL ALA PHE SER ARG GLU PHE SER
SEQRES   5 F  261  ALA ASP VAL LYS ARG ILE ALA VAL GLN TYR PRO GLY GLN
SEQRES   6 F  261  HIS ASP ARG SER GLY LEU PRO PRO LEU GLU SER ILE PRO
SEQRES   7 F  261  THR LEU ALA ASP GLU ILE PHE ALA MET MET LYS PRO SER
SEQRES   8 F  261  ALA ARG ILE ASP ASP PRO VAL ALA PHE PHE GLY HIS SER
SEQRES   9 F  261  MET GLY GLY MET LEU ALA PHE GLU VAL ALA LEU ARG TYR
SEQRES  10 F  261  GLN SER ALA GLY HIS ARG VAL LEU ALA PHE PHE VAL SER
SEQRES  11 F  261  ALA CYS SER ALA PRO GLY HIS ILE ARG TYR LYS GLN LEU
SEQRES  12 F  261  GLN ASP LEU SER ASP ARG GLU MET LEU ASP LEU PHE THR
SEQRES  13 F  261  ARG MET THR GLY MET ASN PRO ASP PHE PHE THR ASP ASP
SEQRES  14 F  261  GLU PHE PHE VAL GLY ALA LEU PRO THR LEU ARG ALA VAL
SEQRES  15 F  261  ARG ALA ILE ALA GLY TYR SER CYS PRO PRO GLU THR LYS
SEQRES  16 F  261  LEU SER CYS PRO ILE TYR ALA PHE ILE GLY ASP LYS ASP
SEQRES  17 F  261  TRP ILE ALA THR GLN ASP ASP MET ASP PRO TRP ARG ASP
SEQRES  18 F  261  ARG THR THR GLU GLU PHE SER ILE ARG VAL PHE PRO GLY
SEQRES  19 F  261  ASP HIS PHE TYR LEU ASN ASP ASN LEU PRO GLU LEU VAL
SEQRES  20 F  261  SER ASP ILE GLU ASP LYS THR LEU GLN TRP HIS ASP ARG
SEQRES  21 F  261  ALA
SEQRES   1 G  261  MET LEU ALA ARG HIS GLY PRO ARG TYR GLY GLY SER VAL
SEQRES   2 G  261  ASN GLY HIS SER ASP ASP SER SER GLY ASP ALA LYS GLN
SEQRES   3 G  261  ALA ALA PRO THR LEU TYR ILE PHE PRO HIS ALA GLY GLY
SEQRES   4 G  261  THR ALA LYS ASP TYR VAL ALA PHE SER ARG GLU PHE SER
SEQRES   5 G  261  ALA ASP VAL LYS ARG ILE ALA VAL GLN TYR PRO GLY GLN
SEQRES   6 G  261  HIS ASP ARG SER GLY LEU PRO PRO LEU GLU SER ILE PRO
SEQRES   7 G  261  THR LEU ALA ASP GLU ILE PHE ALA MET MET LYS PRO SER
SEQRES   8 G  261  ALA ARG ILE ASP ASP PRO VAL ALA PHE PHE GLY HIS SER
SEQRES   9 G  261  MET GLY GLY MET LEU ALA PHE GLU VAL ALA LEU ARG TYR
SEQRES  10 G  261  GLN SER ALA GLY HIS ARG VAL LEU ALA PHE PHE VAL SER
SEQRES  11 G  261  ALA CYS SER ALA PRO GLY HIS ILE ARG TYR LYS GLN LEU
SEQRES  12 G  261  GLN ASP LEU SER ASP ARG GLU MET LEU ASP LEU PHE THR
SEQRES  13 G  261  ARG MET THR GLY MET ASN PRO ASP PHE PHE THR ASP ASP
SEQRES  14 G  261  GLU PHE PHE VAL GLY ALA LEU PRO THR LEU ARG ALA VAL
SEQRES  15 G  261  ARG ALA ILE ALA GLY TYR SER CYS PRO PRO GLU THR LYS
SEQRES  16 G  261  LEU SER CYS PRO ILE TYR ALA PHE ILE GLY ASP LYS ASP
SEQRES  17 G  261  TRP ILE ALA THR GLN ASP ASP MET ASP PRO TRP ARG ASP
SEQRES  18 G  261  ARG THR THR GLU GLU PHE SER ILE ARG VAL PHE PRO GLY
SEQRES  19 G  261  ASP HIS PHE TYR LEU ASN ASP ASN LEU PRO GLU LEU VAL
SEQRES  20 G  261  SER ASP ILE GLU ASP LYS THR LEU GLN TRP HIS ASP ARG
SEQRES  21 G  261  ALA
SEQRES   1 H  261  MET LEU ALA ARG HIS GLY PRO ARG TYR GLY GLY SER VAL
SEQRES   2 H  261  ASN GLY HIS SER ASP ASP SER SER GLY ASP ALA LYS GLN
SEQRES   3 H  261  ALA ALA PRO THR LEU TYR ILE PHE PRO HIS ALA GLY GLY
SEQRES   4 H  261  THR ALA LYS ASP TYR VAL ALA PHE SER ARG GLU PHE SER
SEQRES   5 H  261  ALA ASP VAL LYS ARG ILE ALA VAL GLN TYR PRO GLY GLN
SEQRES   6 H  261  HIS ASP ARG SER GLY LEU PRO PRO LEU GLU SER ILE PRO
SEQRES   7 H  261  THR LEU ALA ASP GLU ILE PHE ALA MET MET LYS PRO SER
SEQRES   8 H  261  ALA ARG ILE ASP ASP PRO VAL ALA PHE PHE GLY HIS SER
SEQRES   9 H  261  MET GLY GLY MET LEU ALA PHE GLU VAL ALA LEU ARG TYR
SEQRES  10 H  261  GLN SER ALA GLY HIS ARG VAL LEU ALA PHE PHE VAL SER
SEQRES  11 H  261  ALA CYS SER ALA PRO GLY HIS ILE ARG TYR LYS GLN LEU
SEQRES  12 H  261  GLN ASP LEU SER ASP ARG GLU MET LEU ASP LEU PHE THR
SEQRES  13 H  261  ARG MET THR GLY MET ASN PRO ASP PHE PHE THR ASP ASP
SEQRES  14 H  261  GLU PHE PHE VAL GLY ALA LEU PRO THR LEU ARG ALA VAL
SEQRES  15 H  261  ARG ALA ILE ALA GLY TYR SER CYS PRO PRO GLU THR LYS
SEQRES  16 H  261  LEU SER CYS PRO ILE TYR ALA PHE ILE GLY ASP LYS ASP
SEQRES  17 H  261  TRP ILE ALA THR GLN ASP ASP MET ASP PRO TRP ARG ASP
SEQRES  18 H  261  ARG THR THR GLU GLU PHE SER ILE ARG VAL PHE PRO GLY
SEQRES  19 H  261  ASP HIS PHE TYR LEU ASN ASP ASN LEU PRO GLU LEU VAL
SEQRES  20 H  261  SER ASP ILE GLU ASP LYS THR LEU GLN TRP HIS ASP ARG
SEQRES  21 H  261  ALA
HET    E9H  A 401       7
HET    MPD  A 402       8
HET    MPD  A 403       8
HET     CA  A 404       1
HET    E9H  B 401       5
HET    MPD  B 402       8
HET    MPD  B 403       8
HET    E9H  C 301       8
HET     CA  C 302       1
HET    MPD  C 303       8
HET    MPD  C 304       8
HET    E9H  D 301       8
HET    MPD  D 302       8
HET    MPD  D 303       8
HET    E9H  E 301       6
HET    MPD  E 302       8
HET    E9H  F 301       5
HET    MPD  F 302       8
HET    MPD  F 303       8
HET    E9H  G 301       5
HET    MPD  G 302       8
HET    E9H  H 301       6
HETNAM     E9H HEXADECYL DIHYDROGEN PHOSPHATE
HETNAM     MPD (4S)-2-METHYL-2,4-PENTANEDIOL
HETNAM      CA CALCIUM ION
FORMUL   9  E9H    8(C16 H35 O4 P)
FORMUL  10  MPD    12(C6 H14 O2)
FORMUL  12   CA    2(CA 2+)
FORMUL  31  HOH   *466(H2 O)
HELIX    1 AA1 THR A   40  ASP A   43  5                                   4
HELIX    2 AA2 TYR A   44  GLU A   50  1                                   7
HELIX    3 AA3 SER A   76  LYS A   89  1                                  14
HELIX    4 AA4 PRO A   90  ALA A   92  5                                   3
HELIX    5 AA5 SER A  104  ALA A  120  1                                  17
HELIX    6 AA6 ARG A  149  LEU A  154  1                                   6
HELIX    7 AA7 ALA A  175  GLY A  187  1                                  13
HELIX    8 AA8 THR A  212  ASP A  217  1                                   6
HELIX    9 AA9 PRO A  218  THR A  223  5                                   6
HELIX   10 AB1 PHE A  237  ASP A  241  5                                   5
HELIX   11 AB2 ASN A  242  HIS A  258  1                                  17
HELIX   12 AB3 THR B   40  ASP B   43  5                                   4
HELIX   13 AB4 TYR B   44  GLU B   50  1                                   7
HELIX   14 AB5 SER B   76  LYS B   89  1                                  14
HELIX   15 AB6 PRO B   90  ALA B   92  5                                   3
HELIX   16 AB7 SER B  104  ALA B  120  1                                  17
HELIX   17 AB8 ARG B  149  ARG B  157  1                                   9
HELIX   18 AB9 PHE B  172  GLY B  174  5                                   3
HELIX   19 AC1 ALA B  175  GLY B  187  1                                  13
HELIX   20 AC2 THR B  212  ASP B  217  1                                   6
HELIX   21 AC3 PRO B  218  THR B  223  5                                   6
HELIX   22 AC4 PHE B  237  ASP B  241  5                                   5
HELIX   23 AC5 ASN B  242  HIS B  258  1                                  17
HELIX   24 AC6 THR C   40  ASP C   43  5                                   4
HELIX   25 AC7 TYR C   44  GLU C   50  1                                   7
HELIX   26 AC8 SER C   76  MET C   87  1                                  12
HELIX   27 AC9 SER C  104  ALA C  120  1                                  17
HELIX   28 AD1 ARG C  149  THR C  156  1                                   8
HELIX   29 AD2 ALA C  175  GLY C  187  1                                  13
HELIX   30 AD3 THR C  212  ASP C  217  1                                   6
HELIX   31 AD4 PRO C  218  THR C  223  5                                   6
HELIX   32 AD5 PHE C  237  ASP C  241  5                                   5
HELIX   33 AD6 ASN C  242  HIS C  258  1                                  17
HELIX   34 AD7 THR D   40  ASP D   43  5                                   4
HELIX   35 AD8 TYR D   44  GLU D   50  1                                   7
HELIX   36 AD9 SER D   76  LYS D   89  1                                  14
HELIX   37 AE1 PRO D   90  ALA D   92  5                                   3
HELIX   38 AE2 SER D  104  ALA D  120  1                                  17
HELIX   39 AE3 LEU D  146  MET D  158  1                                  13
HELIX   40 AE4 ALA D  175  GLY D  187  1                                  13
HELIX   41 AE5 THR D  212  ASP D  217  1                                   6
HELIX   42 AE6 PRO D  218  THR D  223  5                                   6
HELIX   43 AE7 PHE D  237  ASP D  241  5                                   5
HELIX   44 AE8 ASN D  242  ARG D  260  1                                  19
HELIX   45 AE9 THR E   40  ASP E   43  5                                   4
HELIX   46 AF1 TYR E   44  GLU E   50  1                                   7
HELIX   47 AF2 SER E   76  LYS E   89  1                                  14
HELIX   48 AF3 PRO E   90  ALA E   92  5                                   3
HELIX   49 AF4 SER E  104  ALA E  120  1                                  17
HELIX   50 AF5 LEU E  146  MET E  158  1                                  13
HELIX   51 AF6 ALA E  175  GLY E  187  1                                  13
HELIX   52 AF7 THR E  212  ASP E  217  1                                   6
HELIX   53 AF8 PRO E  218  THR E  223  5                                   6
HELIX   54 AF9 PHE E  237  ASP E  241  5                                   5
HELIX   55 AG1 ASN E  242  ASP E  259  1                                  18
HELIX   56 AG2 THR F   40  ASP F   43  5                                   4
HELIX   57 AG3 TYR F   44  GLU F   50  1                                   7
HELIX   58 AG4 SER F   76  LYS F   89  1                                  14
HELIX   59 AG5 PRO F   90  ALA F   92  5                                   3
HELIX   60 AG6 SER F  104  ALA F  120  1                                  17
HELIX   61 AG7 ARG F  149  THR F  156  1                                   8
HELIX   62 AG8 ALA F  175  GLY F  187  1                                  13
HELIX   63 AG9 THR F  212  ASP F  217  1                                   6
HELIX   64 AH1 PRO F  218  THR F  223  5                                   6
HELIX   65 AH2 PHE F  237  ASP F  241  5                                   5
HELIX   66 AH3 ASN F  242  HIS F  258  1                                  17
HELIX   67 AH4 THR G   40  ASP G   43  5                                   4
HELIX   68 AH5 TYR G   44  GLU G   50  1                                   7
HELIX   69 AH6 SER G   76  LYS G   89  1                                  14
HELIX   70 AH7 PRO G   90  ALA G   92  5                                   3
HELIX   71 AH8 SER G  104  ALA G  120  1                                  17
HELIX   72 AH9 ARG G  149  LEU G  154  1                                   6
HELIX   73 AI1 ALA G  175  GLY G  187  1                                  13
HELIX   74 AI2 THR G  212  ASP G  217  1                                   6
HELIX   75 AI3 PRO G  218  THR G  223  5                                   6
HELIX   76 AI4 PHE G  237  ASP G  241  5                                   5
HELIX   77 AI5 ASN G  242  LEU G  255  1                                  14
HELIX   78 AI6 ALA H   41  ASP H   43  5                                   3
HELIX   79 AI7 TYR H   44  GLU H   50  1                                   7
HELIX   80 AI8 ILE H   77  MET H   87  1                                  11
HELIX   81 AI9 MET H   88  ALA H   92  5                                   5
HELIX   82 AJ1 SER H  104  ALA H  120  1                                  17
HELIX   83 AJ2 ARG H  149  THR H  156  1                                   8
HELIX   84 AJ3 ALA H  175  GLY H  187  1                                  13
HELIX   85 AJ4 THR H  212  ASP H  217  1                                   6
HELIX   86 AJ5 PRO H  218  THR H  223  5                                   6
HELIX   87 AJ6 PHE H  237  ASP H  241  5                                   5
HELIX   88 AJ7 ASN H  242  ASP H  259  1                                  18
SHEET    1 AA1 6 LYS A  56  ALA A  59  0
SHEET    2 AA1 6 THR A  30  PHE A  34  1  N  LEU A  31   O  LYS A  56
SHEET    3 AA1 6 PRO A  97  HIS A 103  1  O  PHE A 101   N  PHE A  34
SHEET    4 AA1 6 ARG A 123  SER A 130  1  O  PHE A 128   N  PHE A 100
SHEET    5 AA1 6 ILE A 200  GLY A 205  1  O  TYR A 201   N  PHE A 127
SHEET    6 AA1 6 PHE A 227  PHE A 232  1  O  SER A 228   N  ALA A 202
SHEET    1 AA2 6 LYS B  56  ALA B  59  0
SHEET    2 AA2 6 THR B  30  PHE B  34  1  N  LEU B  31   O  LYS B  56
SHEET    3 AA2 6 PRO B  97  HIS B 103  1  O  PHE B 101   N  PHE B  34
SHEET    4 AA2 6 ARG B 123  SER B 130  1  O  PHE B 128   N  PHE B 100
SHEET    5 AA2 6 ILE B 200  GLY B 205  1  O  TYR B 201   N  PHE B 127
SHEET    6 AA2 6 PHE B 227  PHE B 232  1  O  SER B 228   N  ALA B 202
SHEET    1 AA3 6 LYS C  56  ALA C  59  0
SHEET    2 AA3 6 THR C  30  PHE C  34  1  N  LEU C  31   O  LYS C  56
SHEET    3 AA3 6 PRO C  97  HIS C 103  1  O  PHE C 101   N  PHE C  34
SHEET    4 AA3 6 ARG C 123  SER C 130  1  O  PHE C 128   N  PHE C 100
SHEET    5 AA3 6 ILE C 200  GLY C 205  1  O  TYR C 201   N  PHE C 127
SHEET    6 AA3 6 PHE C 227  PHE C 232  1  O  SER C 228   N  ALA C 202
SHEET    1 AA4 6 LYS D  56  ALA D  59  0
SHEET    2 AA4 6 THR D  30  PHE D  34  1  N  LEU D  31   O  LYS D  56
SHEET    3 AA4 6 PRO D  97  HIS D 103  1  O  PHE D 101   N  PHE D  34
SHEET    4 AA4 6 ARG D 123  SER D 130  1  O  PHE D 128   N  PHE D 100
SHEET    5 AA4 6 ILE D 200  GLY D 205  1  O  TYR D 201   N  PHE D 127
SHEET    6 AA4 6 PHE D 227  PHE D 232  1  O  SER D 228   N  ALA D 202
SHEET    1 AA5 6 LYS E  56  ALA E  59  0
SHEET    2 AA5 6 THR E  30  PHE E  34  1  N  LEU E  31   O  LYS E  56
SHEET    3 AA5 6 PRO E  97  HIS E 103  1  O  PHE E 101   N  PHE E  34
SHEET    4 AA5 6 ARG E 123  SER E 130  1  O  PHE E 128   N  PHE E 100
SHEET    5 AA5 6 ILE E 200  GLY E 205  1  O  TYR E 201   N  PHE E 127
SHEET    6 AA5 6 PHE E 227  PHE E 232  1  O  SER E 228   N  ALA E 202
SHEET    1 AA6 6 LYS F  56  ALA F  59  0
SHEET    2 AA6 6 THR F  30  PHE F  34  1  N  LEU F  31   O  LYS F  56
SHEET    3 AA6 6 PRO F  97  HIS F 103  1  O  PHE F 101   N  PHE F  34
SHEET    4 AA6 6 ARG F 123  SER F 130  1  O  PHE F 128   N  PHE F 100
SHEET    5 AA6 6 ILE F 200  GLY F 205  1  O  TYR F 201   N  PHE F 127
SHEET    6 AA6 6 PHE F 227  PHE F 232  1  O  SER F 228   N  ALA F 202
SHEET    1 AA7 6 LYS G  56  ALA G  59  0
SHEET    2 AA7 6 THR G  30  PHE G  34  1  N  LEU G  31   O  LYS G  56
SHEET    3 AA7 6 PRO G  97  HIS G 103  1  O  PHE G 101   N  PHE G  34
SHEET    4 AA7 6 ARG G 123  SER G 130  1  O  PHE G 128   N  PHE G 100
SHEET    5 AA7 6 ILE G 200  GLY G 205  1  O  TYR G 201   N  PHE G 127
SHEET    6 AA7 6 PHE G 227  PHE G 232  1  O  SER G 228   N  ALA G 202
SHEET    1 AA8 6 LYS H  56  ALA H  59  0
SHEET    2 AA8 6 THR H  30  PHE H  34  1  N  LEU H  31   O  LYS H  56
SHEET    3 AA8 6 PRO H  97  HIS H 103  1  O  PHE H 101   N  TYR H  32
SHEET    4 AA8 6 ARG H 123  SER H 130  1  O  PHE H 128   N  PHE H 100
SHEET    5 AA8 6 ILE H 200  GLY H 205  1  O  TYR H 201   N  PHE H 127
SHEET    6 AA8 6 PHE H 227  PHE H 232  1  O  SER H 228   N  ALA H 202
LINK         OE1 GLU A  50                CA    CA A 404     1555   1555  2.70
LINK         OG  SER A 104                 P1  E9H A 401     1555   1555  1.61
LINK         OG  SER B 104                 P1  E9H B 401     1555   1555  1.60
LINK         OG  SER C 104                 P1  E9H C 301     1555   1555  1.61
LINK         O   ARG D  49                CA    CA A 404     1555   1555  2.34
LINK         O   PHE D  51                CA    CA A 404     1555   1555  2.41
LINK         OG  SER D 104                 P1  E9H D 301     1555   1555  1.60
LINK         OG  SER E 104                 P1  E9H E 301     1555   1555  1.61
LINK         OG  SER F 104                 P1  E9H F 301     1555   1555  1.61
LINK         OG  SER G 104                 P1  E9H G 301     1555   1555  1.61
LINK         OG  SER H 104                 P1  E9H H 301     1555   1555  1.61
LINK        CA    CA C 302                 O   HOH C 409     1555   1555  2.65
LINK        CA    CA C 302                 O   HOH B 553     1555   1455  2.98
SITE     1 AC1  7 HIS A  36  ALA A  37  SER A 104  MET A 105
SITE     2 AC1  7 HIS A 236  MPD A 402  HOH A 511
SITE     1 AC2  7 ALA A 131  CYS A 132  SER A 133  ILE A 185
SITE     2 AC2  7 ILE A 210  E9H A 401  ARG F 139
SITE     1 AC3  4 ASP A  43  PHE A 237  ASN A 240  ARG D  49
SITE     1 AC4  4 GLU A  50  LEU A 243  ARG D  49  PHE D  51
SITE     1 AC5  4 SER B 104  SER B 133  ILE B 210  E9H B 401
SITE     1 AC6  5 HIS B  36  ASP B  43  PHE B 237  ASN B 240
SITE     2 AC6  5 HOH B 507
SITE     1 AC7  3 HOH B 553  ARG C  49  HOH C 409
SITE     1 AC8  4 MET C 108  CYS C 132  SER C 133  E9H C 301
SITE     1 AC9  4 HIS C  36  ASP C  43  ASN C 240  HOH C 412
SITE     1 AD1  6 MET D 108  ALA D 131  SER D 133  ILE D 138
SITE     2 AD1  6 ILE D 210  E9H D 301
SITE     1 AD2  4 ASP D  43  TYR D  44  PHE D 237  ASN D 240
SITE     1 AD3  7 SER E 104  MET E 105  ALA E 131  SER E 133
SITE     2 AD3  7 ARG E 139  ILE E 210  E9H E 301
SITE     1 AD4  7 SER F 104  MET F 108  CYS F 132  SER F 133
SITE     2 AD4  7 ILE F 138  ILE F 185  ILE F 210
SITE     1 AD5  5 HIS F  36  ASP F  43  TYR F  44  PHE F 237
SITE     2 AD5  5 ASN F 240
SITE     1 AD6  4 SER G 104  ALA G 131  SER G 133  ILE G 210
SITE     1 AD7 11 HIS B  36  ALA B  37  HIS B 103  MET B 105
SITE     2 AD7 11 GLY B 106  GLY B 107  SER B 130  ALA B 131
SITE     3 AD7 11 CYS B 132  HIS B 236  MPD B 402
SITE     1 AD8 11 HIS C  36  ALA C  37  HIS C 103  MET C 105
SITE     2 AD8 11 GLY C 106  GLY C 107  SER C 130  ALA C 131
SITE     3 AD8 11 CYS C 132  HIS C 236  MPD C 303
SITE     1 AD9 11 HIS D  36  ALA D  37  HIS D 103  MET D 105
SITE     2 AD9 11 GLY D 106  GLY D 107  SER D 130  ALA D 131
SITE     3 AD9 11 CYS D 132  HIS D 236  MPD D 302
SITE     1 AE1 12 HIS E  36  ALA E  37  HIS E 103  MET E 105
SITE     2 AE1 12 GLY E 106  GLY E 107  SER E 130  ALA E 131
SITE     3 AE1 12 CYS E 132  HIS E 236  MPD E 302  HOH E 405
SITE     1 AE2 12 HIS F  36  ALA F  37  HIS F 103  MET F 105
SITE     2 AE2 12 GLY F 106  GLY F 107  SER F 130  ALA F 131
SITE     3 AE2 12 CYS F 132  HIS F 236  MPD F 302  HOH F 410
SITE     1 AE3 11 HIS G  36  ALA G  37  HIS G 103  MET G 105
SITE     2 AE3 11 GLY G 106  GLY G 107  SER G 130  ALA G 131
SITE     3 AE3 11 CYS G 132  HIS G 236  MPD G 302
SITE     1 AE4 11 ARG D 157  HIS H  36  ALA H  37  HIS H 103
SITE     2 AE4 11 MET H 105  GLY H 106  GLY H 107  SER H 130
SITE     3 AE4 11 ALA H 131  CYS H 132  HIS H 236
CRYST1   79.070  224.580  222.210  90.00  90.00  90.00 C 2 2 21     64
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.012647  0.000000  0.000000        0.00000
SCALE2      0.000000  0.004453  0.000000        0.00000
SCALE3      0.000000  0.000000  0.004500        0.00000
TER    1599      ASP A 259
TER    3228      ARG B 260
TER    4819      HIS C 258
TER    6516      ARG D 260
TER    8168      ASP E 259
TER    9785      HIS F 258
TER   11363      ASP G 259
TER   12943      ASP H 259
MASTER     1229    0   22   88   48    0   43    613549    8  160  168
END