longtext: 6fz8-pdb

content
HEADER    HYDROLASE                               14-MAR-18   6FZ8
TITLE     CRYSTAL STRUCTURE OF LIPASE FROM GEOBACILLUS STEAROTHERMOPHILUS T6
TITLE    2 METHANOL STABLE VARIANT L184F/A187F
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: LIPASE;
COMPND   3 CHAIN: A;
COMPND   4 EC: 3.1.1.3;
COMPND   5 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: GEOBACILLUS STEAROTHERMOPHILUS;
SOURCE   3 ORGANISM_TAXID: 1422;
SOURCE   4 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3);
SOURCE   5 EXPRESSION_SYSTEM_TAXID: 469008
KEYWDS    LIPASE, METHANOL, ORGANIC SOLVENT, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    S.GIHAZ,M.KANTEEV,Y.PAZY,A.FISHMAN
REVDAT   1   17-OCT-18 6FZ8    0
JRNL        AUTH   S.GIHAZ,M.KANTEEV,Y.PAZY,A.FISHMAN
JRNL        TITL   FILLING THE VOID: INTRODUCING AROMATIC INTERACTIONS INTO
JRNL        TITL 2 SOLVENT TUNNELS TOWARDS LIPASE STABILITY IN METHANOL.
JRNL        REF    APPL. ENVIRON. MICROBIOL.                  2018
JRNL        REFN                   ESSN 1098-5336
JRNL        PMID   30217852
JRNL        DOI    10.1128/AEM.02143-18
REMARK   2
REMARK   2 RESOLUTION.    2.20 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX (1.10.1_2155: ???)
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : NULL
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.20
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 57.12
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.340
REMARK   3   COMPLETENESS FOR RANGE        (%) : 98.3
REMARK   3   NUMBER OF REFLECTIONS             : 21111
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.224
REMARK   3   R VALUE            (WORKING SET) : 0.224
REMARK   3   FREE R VALUE                     : 0.236
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.880
REMARK   3   FREE R VALUE TEST SET COUNT      : 1031
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 57.1342 -  4.2080    0.97     2964   165  0.1980 0.2067
REMARK   3     2  4.2080 -  3.3401    0.97     2877   133  0.2010 0.2175
REMARK   3     3  3.3401 -  2.9179    0.98     2859   136  0.2304 0.2131
REMARK   3     4  2.9179 -  2.6511    0.99     2885   129  0.2431 0.2624
REMARK   3     5  2.6511 -  2.4611    0.99     2841   158  0.2363 0.2550
REMARK   3     6  2.4611 -  2.3160    0.99     2826   155  0.2556 0.3269
REMARK   3     7  2.3160 -  2.2000    0.99     2828   155  0.2718 0.2607
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : NULL
REMARK   3   SOLVENT RADIUS     : 1.11
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.220
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 21.400
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :  0.027           3208
REMARK   3   ANGLE     :  1.887           4361
REMARK   3   CHIRALITY :  0.183            450
REMARK   3   PLANARITY :  0.010            573
REMARK   3   DIHEDRAL  : 16.003           1135
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 6FZ8 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 15-MAR-18.
REMARK 100 THE DEPOSITION ID IS D_1200009170.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 20-MAY-17
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : NULL
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : ESRF
REMARK 200  BEAMLINE                       : ID29
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.07227
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : PIXEL
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS PILATUS 6M
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : IMOSFLM
REMARK 200  DATA SCALING SOFTWARE          : SCALA
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 21175
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.200
REMARK 200  RESOLUTION RANGE LOW       (A) : 71.870
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 98.5
REMARK 200  DATA REDUNDANCY                : 4.500
REMARK 200  R MERGE                    (I) : 0.10400
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 10.0000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.20
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.32
REMARK 200  COMPLETENESS FOR SHELL     (%) : NULL
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL
REMARK 200  R MERGE FOR SHELL          (I) : NULL
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: 4X6U
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 46.91
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.32
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.2M SODIUM FORMATE, 20% PEG 3350,
REMARK 280  VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 293K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X+1/2,-Y,Z+1/2
REMARK 290       3555   -X,Y+1/2,-Z+1/2
REMARK 290       4555   X+1/2,-Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       24.86000
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       57.11500
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       35.93500
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       57.11500
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       24.86000
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       35.93500
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 90 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 15670 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -12.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   O    HOH A   605     O    HOH A   613              1.87
REMARK 500   O    HOH A   556     O    HOH A   591              1.89
REMARK 500   O    HOH A   645     O    HOH A   669              2.10
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS
REMARK 500
REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC
REMARK 500 SYMMETRY ARE IN CLOSE CONTACT.  AN ATOM LOCATED WITHIN 0.15
REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A
REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375
REMARK 500 INSTEAD OF REMARK 500.  ATOMS WITH NON-BLANK ALTERNATE
REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS.
REMARK 500
REMARK 500 DISTANCE CUTOFF:
REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS
REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI  SSYMOP   DISTANCE
REMARK 500   O    HOH A   528     O    HOH A   577     2454     1.82
REMARK 500   O    HOH A   647     O    HOH A   666     4555     2.13
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    SER A 114     -123.52     59.32
REMARK 500    VAL A 204      -62.62     62.49
REMARK 500    ARG A 272       53.43   -146.96
REMARK 500    ASN A 305       93.16   -163.23
REMARK 500    ASP A 311     -168.24   -125.75
REMARK 500    LYS A 330      -50.13   -132.83
REMARK 500
REMARK 500 REMARK: NULL
REMARK 620
REMARK 620 METAL COORDINATION
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              ZN A 401  ZN
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 ASP A  62   OD1
REMARK 620 2 HIS A  82   NE2  95.5
REMARK 620 3 HIS A  88   NE2 122.5 107.8
REMARK 620 4 ASP A 239   OD2 124.7 101.6 101.4
REMARK 620 N                    1     2     3
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA A 402  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 GLY A 287   O
REMARK 620 2 GLU A 361   OE2  85.6
REMARK 620 3 ASP A 366   OD2 100.7  92.6
REMARK 620 4 PRO A 367   O   177.7  96.7  79.6
REMARK 620 5 HOH A 578   O    74.7 160.1  93.5 103.0
REMARK 620 6 HOH A 590   O    83.6  86.7 175.6  96.2  88.6
REMARK 620 N                    1     2     3     4     5
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN A 401
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CA A 402
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 4X6U, 6FZ1, 6FZ7   RELATED DB: PDB
DBREF  6FZ8 A    4   389  UNP    Q93A71   Q93A71_GEOSE    33    418
SEQADV 6FZ8 PHE A  184  UNP  Q93A71    LEU   213 ENGINEERED MUTATION
SEQADV 6FZ8 PHE A  187  UNP  Q93A71    ALA   216 ENGINEERED MUTATION
SEQADV 6FZ8 ALA A  323  UNP  Q93A71    THR   352 CONFLICT
SEQADV 6FZ8 HIS A  390  UNP  Q93A71              EXPRESSION TAG
SEQADV 6FZ8 HIS A  391  UNP  Q93A71              EXPRESSION TAG
SEQADV 6FZ8 HIS A  392  UNP  Q93A71              EXPRESSION TAG
SEQADV 6FZ8 HIS A  393  UNP  Q93A71              EXPRESSION TAG
SEQADV 6FZ8 HIS A  394  UNP  Q93A71              EXPRESSION TAG
SEQADV 6FZ8 HIS A  395  UNP  Q93A71              EXPRESSION TAG
SEQRES   1 A  392  SER ARG ALA ASN ASP ALA PRO ILE VAL LEU LEU HIS GLY
SEQRES   2 A  392  PHE THR GLY TRP GLY ARG GLU GLU MET PHE GLY PHE LYS
SEQRES   3 A  392  TYR TRP GLY GLY VAL ARG GLY ASP ILE GLU GLN TRP LEU
SEQRES   4 A  392  ASN ASP ASN GLY TYR ARG THR TYR THR LEU ALA VAL GLY
SEQRES   5 A  392  PRO LEU SER SER ASN TRP ASP ARG ALA CYS GLU ALA TYR
SEQRES   6 A  392  ALA GLN LEU VAL GLY GLY THR VAL ASP TYR GLY ALA ALA
SEQRES   7 A  392  HIS ALA ALA LYS HIS GLY HIS ALA ARG PHE GLY ARG THR
SEQRES   8 A  392  TYR PRO GLY LEU LEU PRO GLU LEU LYS ARG GLY GLY ARG
SEQRES   9 A  392  ILE HIS ILE ILE ALA HIS SER GLN GLY GLY GLN THR ALA
SEQRES  10 A  392  ARG MET LEU VAL SER LEU LEU GLU ASN GLY SER GLN GLU
SEQRES  11 A  392  GLU ARG GLU TYR ALA LYS ALA HIS ASN VAL SER LEU SER
SEQRES  12 A  392  PRO LEU PHE GLU GLY GLY HIS HIS PHE VAL LEU SER VAL
SEQRES  13 A  392  THR THR ILE ALA THR PRO HIS ASP GLY THR THR LEU VAL
SEQRES  14 A  392  ASN MET VAL ASP PHE THR ASP ARG PHE PHE ASP PHE GLN
SEQRES  15 A  392  LYS PHE VAL LEU LYS ALA ALA ALA VAL ALA SER ASN VAL
SEQRES  16 A  392  PRO TYR THR SER GLN VAL TYR ASP PHE LYS LEU ASP GLN
SEQRES  17 A  392  TRP GLY LEU ARG ARG GLN PRO GLY GLU SER PHE ASP GLN
SEQRES  18 A  392  TYR PHE GLU ARG LEU LYS ARG SER PRO VAL TRP THR SER
SEQRES  19 A  392  THR ASP THR ALA ARG TYR ASP LEU SER VAL PRO GLY ALA
SEQRES  20 A  392  GLU LYS LEU ASN GLN TRP VAL LYS ALA SER PRO ASN THR
SEQRES  21 A  392  TYR TYR LEU SER PHE ALA THR GLU ARG THR TYR ARG GLY
SEQRES  22 A  392  ALA LEU THR GLY ASN TYR TYR PRO GLU LEU GLY MET ASN
SEQRES  23 A  392  ALA PHE SER ALA VAL VAL CYS ALA PRO PHE LEU GLY SER
SEQRES  24 A  392  TYR ARG ASN ALA THR LEU GLY ILE ASP ASP ARG TRP LEU
SEQRES  25 A  392  GLU ASN ASP GLY ILE VAL ASN ALA PHE SER MET ASN GLY
SEQRES  26 A  392  PRO LYS ARG GLY SER THR ASP ARG ILE VAL PRO TYR ASP
SEQRES  27 A  392  GLY THR ILE LYS LYS GLY VAL TRP ASN ASP MET GLY THR
SEQRES  28 A  392  TYR ASN VAL ASP HIS LEU GLU VAL ILE GLY VAL ASP PRO
SEQRES  29 A  392  ASN PRO LEU PHE ASP ILE ARG ALA PHE TYR LEU ARG LEU
SEQRES  30 A  392  ALA GLU GLN LEU ALA SER LEU GLN PRO HIS HIS HIS HIS
SEQRES  31 A  392  HIS HIS
HET     ZN  A 401       1
HET     CA  A 402       1
HETNAM      ZN ZINC ION
HETNAM      CA CALCIUM ION
FORMUL   2   ZN    ZN 2+
FORMUL   3   CA    CA 2+
FORMUL   4  HOH   *184(H2 O)
HELIX    1 AA1 GLU A   24  PHE A   28  5                                   5
HELIX    2 AA2 GLY A   32  GLY A   36  5                                   5
HELIX    3 AA3 ASP A   37  ASN A   45  1                                   9
HELIX    4 AA4 SER A   59  GLY A   73  1                                  15
HELIX    5 AA5 GLY A   79  GLY A   87  1                                   9
HELIX    6 AA6 LEU A   99  GLY A  105  5                                   7
HELIX    7 AA7 GLN A  115  GLY A  130  1                                  16
HELIX    8 AA8 SER A  131  ASN A  142  1                                  12
HELIX    9 AA9 SER A  146  GLU A  150  5                                   5
HELIX   10 AB1 THR A  169  MET A  174  5                                   6
HELIX   11 AB2 ASP A  176  ALA A  192  1                                  17
HELIX   12 AB3 SER A  221  ARG A  231  1                                  11
HELIX   13 AB4 SER A  232  SER A  237  1                                   6
HELIX   14 AB5 THR A  240  SER A  246  1                                   7
HELIX   15 AB6 SER A  246  VAL A  257  1                                  12
HELIX   16 AB7 ASN A  289  VAL A  295  1                                   7
HELIX   17 AB8 CYS A  296  GLY A  301  1                                   6
HELIX   18 AB9 ASN A  305  GLY A  309  5                                   5
HELIX   19 AC1 ASP A  311  LEU A  315  5                                   5
HELIX   20 AC2 ASN A  322  MET A  326  5                                   5
HELIX   21 AC3 ASP A  372  SER A  386  1                                  15
SHEET    1 AA1 7 THR A  49  THR A  51  0
SHEET    2 AA1 7 ILE A  11  LEU A  14  1  N  ILE A  11   O  TYR A  50
SHEET    3 AA1 7 ILE A 108  HIS A 113  1  O  HIS A 109   N  VAL A  12
SHEET    4 AA1 7 VAL A 156  ILE A 162  1  O  THR A 160   N  ALA A 112
SHEET    5 AA1 7 TYR A 264  THR A 270  1  O  LEU A 266   N  THR A 161
SHEET    6 AA1 7 TRP A 349  TYR A 355  1  O  TYR A 355   N  ALA A 269
SHEET    7 AA1 7 ILE A 337  PRO A 339  1  N  VAL A 338   O  TRP A 349
SHEET    1 AA2 2 GLY A  74  ASP A  77  0
SHEET    2 AA2 2 PHE A  91  TYR A  95 -1  O  TYR A  95   N  GLY A  74
SHEET    1 AA3 2 THR A 273  ARG A 275  0
SHEET    2 AA3 2 TYR A 282  PRO A 284 -1  O  TYR A 283   N  TYR A 274
LINK         OD1 ASP A  62                ZN    ZN A 401     1555   1555  2.08
LINK         NE2 HIS A  82                ZN    ZN A 401     1555   1555  2.43
LINK         NE2 HIS A  88                ZN    ZN A 401     1555   1555  1.90
LINK         OD2 ASP A 239                ZN    ZN A 401     1555   1555  1.84
LINK         O   GLY A 287                CA    CA A 402     1555   1555  2.18
LINK         OE2 GLU A 361                CA    CA A 402     1555   1555  1.92
LINK         OD2 ASP A 366                CA    CA A 402     1555   1555  2.47
LINK         O   PRO A 367                CA    CA A 402     1555   1555  2.47
LINK        CA    CA A 402                 O   HOH A 578     1555   1555  2.44
LINK        CA    CA A 402                 O   HOH A 590     1555   1555  3.04
SITE     1 AC1  4 ASP A  62  HIS A  82  HIS A  88  ASP A 239
SITE     1 AC2  6 GLY A 287  GLU A 361  ASP A 366  PRO A 367
SITE     2 AC2  6 HOH A 578  HOH A 590
CRYST1   49.720   71.870  114.230  90.00  90.00  90.00 P 21 21 21    4
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.020113  0.000000  0.000000        0.00000
SCALE2      0.000000  0.013914  0.000000        0.00000
SCALE3      0.000000  0.000000  0.008754        0.00000
TER    3117      HIS A 395
MASTER      289    0    2   21   11    0    3    6 3302    1   13   31
END