longtext: 6jtt-pdb

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HEADER    HYDROLASE                               12-APR-19   6JTT
TITLE     MHETASE IN COMPLEX WITH BHET
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: MONO(2-HYDROXYETHYL) TEREPHTHALATE HYDROLASE;
COMPND   3 CHAIN: A, B, C;
COMPND   4 FRAGMENT: FERULOYL ESTERASE DOMAIN;
COMPND   5 EC: 3.1.1.102;
COMPND   6 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: IDEONELLA SAKAIENSIS;
SOURCE   3 ORGANISM_TAXID: 1547922;
SOURCE   4 STRAIN: 201-F6;
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3);
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 469008;
SOURCE   7 EXPRESSION_SYSTEM_STRAIN: BL21(DE3);
SOURCE   8 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;
SOURCE   9 EXPRESSION_SYSTEM_PLASMID: PET22B
KEYWDS    HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    H.-Y.SAGONG,H.SEO,K.-J.KIM
REVDAT   1   15-APR-20 6JTT    0
JRNL        AUTH   H.-Y.SAGONG,H.SEO,K.-J.KIM
JRNL        TITL   STRUCTURAL INSIGHT INTO MHET HYDROLYSIS BY MHETASE
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   2
REMARK   2 RESOLUTION.    2.51 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.8.0238
REMARK   3   AUTHORS     : MURSHUDOV,SKUBAK,LEBEDEV,PANNU,STEINER,
REMARK   3               : NICHOLLS,WINN,LONG,VAGIN
REMARK   3
REMARK   3    REFINEMENT TARGET : NULL
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.51
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 33.21
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0.000
REMARK   3   COMPLETENESS FOR RANGE        (%) : 97.9
REMARK   3   NUMBER OF REFLECTIONS             : 108686
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.192
REMARK   3   R VALUE            (WORKING SET) : 0.190
REMARK   3   FREE R VALUE                     : 0.226
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.900
REMARK   3   FREE R VALUE TEST SET COUNT      : 5549
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 2.51
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 2.57
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 7696
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 94.07
REMARK   3   BIN R VALUE           (WORKING SET) : 0.2530
REMARK   3   BIN FREE R VALUE SET COUNT          : 406
REMARK   3   BIN FREE R VALUE                    : 0.3100
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 12369
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 49
REMARK   3   SOLVENT ATOMS            : 500
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 26.54
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : -1.19000
REMARK   3    B22 (A**2) : -1.61000
REMARK   3    B33 (A**2) : 2.34000
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : -0.92000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): 0.233
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.201
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.137
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 6.264
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.935
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.905
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A): 12812 ; 0.011 ; 0.013
REMARK   3   BOND LENGTHS OTHERS               (A): 11298 ; 0.001 ; 0.017
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES): 17421 ; 1.772 ; 1.641
REMARK   3   BOND ANGLES OTHERS          (DEGREES): 26144 ; 1.407 ; 1.575
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):  1675 ; 7.101 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   628 ;32.338 ;21.688
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):  1777 ;15.550 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):    84 ;21.322 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):  1640 ; 0.078 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A): 14925 ; 0.008 ; 0.020
REMARK   3   GENERAL PLANES OTHERS             (A):  2863 ; 0.001 ; 0.020
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN ANGLE OTHER ATOMS   (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN ANGLE OTHER ATOMS   (A**2):  NULL ;  NULL ;  NULL
REMARK   3   LONG RANGE B REFINED ATOMS     (A**2):  NULL ;  NULL ;  NULL
REMARK   3   LONG RANGE B OTHER ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : NULL
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.20
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE RIDING
REMARK   3  POSITIONS U VALUES : REFINED INDIVIDUALLY
REMARK   4
REMARK   4 6JTT COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 16-APR-19.
REMARK 100 THE DEPOSITION ID IS D_1300011800.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 12-MAR-19
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 6.5
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : PAL/PLS
REMARK 200  BEAMLINE                       : 7A (6B, 6C1)
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.97934
REMARK 200  MONOCHROMATOR                  : DOUBLE CRYSTAL MONOCHROMATOR
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 270
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000
REMARK 200  DATA SCALING SOFTWARE          : HKL-2000
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 114235
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.500
REMARK 200  RESOLUTION RANGE LOW       (A) : 33.210
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 98.2
REMARK 200  DATA REDUNDANCY                : 2.100
REMARK 200  R MERGE                    (I) : 0.08600
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 15.7500
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.50
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.54
REMARK 200  COMPLETENESS FOR SHELL     (%) : 98.0
REMARK 200  DATA REDUNDANCY IN SHELL       : 2.20
REMARK 200  R MERGE FOR SHELL          (I) : 0.30800
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: SAD
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 72.27
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 4.44
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: PEG3350, HEPES, TACSIMATE PH 7.0, PH
REMARK 280  6.5, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 293K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: C 1 2 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,Y,-Z
REMARK 290       3555   X+1/2,Y+1/2,Z
REMARK 290       4555   -X+1/2,Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   3  1.000000  0.000000  0.000000      107.62950
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       86.89950
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   4 -1.000000  0.000000  0.000000      107.62950
REMARK 290   SMTRY2   4  0.000000  1.000000  0.000000       86.89950
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2, 3
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 3
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A    -9
REMARK 465     MET A    -8
REMARK 465     ILE A    -7
REMARK 465     THR A    -6
REMARK 465     LEU A    -5
REMARK 465     ARG A    -4
REMARK 465     LYS A    -3
REMARK 465     LEU A    -2
REMARK 465     PRO A    -1
REMARK 465     LEU A     0
REMARK 465     ALA A     1
REMARK 465     VAL A     2
REMARK 465     ALA A     3
REMARK 465     VAL A     4
REMARK 465     ALA A     5
REMARK 465     ALA A     6
REMARK 465     GLY A     7
REMARK 465     VAL A     8
REMARK 465     MET A     9
REMARK 465     SER A    10
REMARK 465     ALA A    11
REMARK 465     GLN A    12
REMARK 465     ALA A    13
REMARK 465     MET A    14
REMARK 465     ALA A    15
REMARK 465     MET A    16
REMARK 465     ALA A    17
REMARK 465     CYS A    18
REMARK 465     ALA A    19
REMARK 465     GLY A    20
REMARK 465     GLY A    21
REMARK 465     GLY A    22
REMARK 465     SER A    23
REMARK 465     THR A    24
REMARK 465     PRO A    25
REMARK 465     LEU A    26
REMARK 465     PRO A    27
REMARK 465     LEU A    28
REMARK 465     PRO A    29
REMARK 465     GLN A    30
REMARK 465     GLN A    31
REMARK 465     GLN A    32
REMARK 465     PRO A    33
REMARK 465     PRO A    34
REMARK 465     GLN A    35
REMARK 465     GLN A    36
REMARK 465     GLU A    37
REMARK 465     PRO A    38
REMARK 465     PRO A    39
REMARK 465     PRO A    40
REMARK 465     PRO A    41
REMARK 465     PRO A    42
REMARK 465     ASP A    56
REMARK 465     LEU A   604
REMARK 465     GLU A   605
REMARK 465     HIS A   606
REMARK 465     HIS A   607
REMARK 465     HIS A   608
REMARK 465     HIS A   609
REMARK 465     HIS A   610
REMARK 465     HIS A   611
REMARK 465     MET B    -9
REMARK 465     MET B    -8
REMARK 465     ILE B    -7
REMARK 465     THR B    -6
REMARK 465     LEU B    -5
REMARK 465     ARG B    -4
REMARK 465     LYS B    -3
REMARK 465     LEU B    -2
REMARK 465     PRO B    -1
REMARK 465     LEU B     0
REMARK 465     ALA B     1
REMARK 465     VAL B     2
REMARK 465     ALA B     3
REMARK 465     VAL B     4
REMARK 465     ALA B     5
REMARK 465     ALA B     6
REMARK 465     GLY B     7
REMARK 465     VAL B     8
REMARK 465     MET B     9
REMARK 465     SER B    10
REMARK 465     ALA B    11
REMARK 465     GLN B    12
REMARK 465     ALA B    13
REMARK 465     MET B    14
REMARK 465     ALA B    15
REMARK 465     MET B    16
REMARK 465     ALA B    17
REMARK 465     CYS B    18
REMARK 465     ALA B    19
REMARK 465     GLY B    20
REMARK 465     GLY B    21
REMARK 465     GLY B    22
REMARK 465     SER B    23
REMARK 465     THR B    24
REMARK 465     PRO B    25
REMARK 465     LEU B    26
REMARK 465     PRO B    27
REMARK 465     LEU B    28
REMARK 465     PRO B    29
REMARK 465     GLN B    30
REMARK 465     GLN B    31
REMARK 465     GLN B    32
REMARK 465     PRO B    33
REMARK 465     PRO B    34
REMARK 465     GLN B    35
REMARK 465     GLN B    36
REMARK 465     GLU B    37
REMARK 465     PRO B    38
REMARK 465     PRO B    39
REMARK 465     PRO B    40
REMARK 465     PRO B    41
REMARK 465     PRO B    42
REMARK 465     ASP B    56
REMARK 465     GLY B    57
REMARK 465     ASN B    58
REMARK 465     GLY B    59
REMARK 465     GLU B   605
REMARK 465     HIS B   606
REMARK 465     HIS B   607
REMARK 465     HIS B   608
REMARK 465     HIS B   609
REMARK 465     HIS B   610
REMARK 465     HIS B   611
REMARK 465     MET C    -9
REMARK 465     MET C    -8
REMARK 465     ILE C    -7
REMARK 465     THR C    -6
REMARK 465     LEU C    -5
REMARK 465     ARG C    -4
REMARK 465     LYS C    -3
REMARK 465     LEU C    -2
REMARK 465     PRO C    -1
REMARK 465     LEU C     0
REMARK 465     ALA C     1
REMARK 465     VAL C     2
REMARK 465     ALA C     3
REMARK 465     VAL C     4
REMARK 465     ALA C     5
REMARK 465     ALA C     6
REMARK 465     GLY C     7
REMARK 465     VAL C     8
REMARK 465     MET C     9
REMARK 465     SER C    10
REMARK 465     ALA C    11
REMARK 465     GLN C    12
REMARK 465     ALA C    13
REMARK 465     MET C    14
REMARK 465     ALA C    15
REMARK 465     MET C    16
REMARK 465     ALA C    17
REMARK 465     CYS C    18
REMARK 465     ALA C    19
REMARK 465     GLY C    20
REMARK 465     GLY C    21
REMARK 465     GLY C    22
REMARK 465     SER C    23
REMARK 465     THR C    24
REMARK 465     PRO C    25
REMARK 465     LEU C    26
REMARK 465     PRO C    27
REMARK 465     LEU C    28
REMARK 465     PRO C    29
REMARK 465     GLN C    30
REMARK 465     GLN C    31
REMARK 465     GLN C    32
REMARK 465     PRO C    33
REMARK 465     PRO C    34
REMARK 465     GLN C    35
REMARK 465     GLN C    36
REMARK 465     GLU C    37
REMARK 465     PRO C    38
REMARK 465     PRO C    39
REMARK 465     PRO C    40
REMARK 465     PRO C    41
REMARK 465     PRO C    42
REMARK 465     ASP C    56
REMARK 465     GLY C    57
REMARK 465     ASN C    58
REMARK 465     GLY C    59
REMARK 465     LEU C   604
REMARK 465     GLU C   605
REMARK 465     HIS C   606
REMARK 465     HIS C   607
REMARK 465     HIS C   608
REMARK 465     HIS C   609
REMARK 465     HIS C   610
REMARK 465     HIS C   611
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     LEU B 604    CG   CD1  CD2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   OG   SER A   225     C10  C9C A   701              1.38
REMARK 500   OG   SER C   225     C10  C9C C   701              1.43
REMARK 500   SG   CYS A    51     O    HOH A   936              1.46
REMARK 500   NH2  ARG A   411     O    ALA A   494              2.09
REMARK 500   OD1  ASP B   307     O    HOH B   801              2.13
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    ASP B 307   CB  -  CA  -  C   ANGL. DEV. = -18.6 DEGREES
REMARK 500    ARG B 480   CB  -  CA  -  C   ANGL. DEV. = -13.1 DEGREES
REMARK 500    ARG B 550   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.7 DEGREES
REMARK 500    ARG C 480   CB  -  CA  -  C   ANGL. DEV. = -16.2 DEGREES
REMARK 500    MET C 490   CG  -  SD  -  CE  ANGL. DEV. = -10.0 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    ALA A  67       41.72    -89.77
REMARK 500    ASN A 134     -144.72     57.14
REMARK 500    ASN A 171       51.32    -98.81
REMARK 500    TYR A 194      -40.60   -150.67
REMARK 500    SER A 225     -121.68     69.15
REMARK 500    ALA A 249       59.73     33.64
REMARK 500    LEU A 309      115.65   -160.81
REMARK 500    ASP A 311       11.41   -147.65
REMARK 500    TYR A 373     -102.56   -145.77
REMARK 500    SER A 383     -142.76   -143.23
REMARK 500    GLU A 429       73.24   -114.80
REMARK 500    SER A 456      119.50   -166.69
REMARK 500    PHE A 517      -19.21   -142.15
REMARK 500    ASN A 527     -145.50    -86.72
REMARK 500    CYS A 529      -26.82     73.01
REMARK 500    PRO A 533       68.68    -68.94
REMARK 500    ALA B  67       35.63    -87.86
REMARK 500    ASN B 134     -145.58     55.17
REMARK 500    ASN B 156       21.26     80.70
REMARK 500    ASN B 171       56.24    -93.09
REMARK 500    TYR B 194      -36.76   -146.09
REMARK 500    SER B 225     -119.20     64.34
REMARK 500    ALA B 249       57.00     32.48
REMARK 500    ASP B 311       11.72   -143.69
REMARK 500    TYR B 373      -95.40   -143.61
REMARK 500    SER B 383     -140.09   -140.60
REMARK 500    SER B 456      114.38   -164.00
REMARK 500    ASN B 527     -147.16    -79.68
REMARK 500    CYS B 529      -23.80     71.43
REMARK 500    TYR B 579      134.64    -38.65
REMARK 500    ALA C  67       42.75    -84.91
REMARK 500    ASN C 134     -141.95     62.79
REMARK 500    ASN C 171       53.88    -98.48
REMARK 500    TYR C 194      -33.52   -148.61
REMARK 500    SER C 225     -116.14     70.35
REMARK 500    ALA C 249       57.12     34.22
REMARK 500    ASP C 311        4.48   -152.00
REMARK 500    TYR C 373     -102.79   -139.05
REMARK 500    SER C 383     -141.53   -135.12
REMARK 500    SER C 404      148.03   -176.86
REMARK 500    GLU C 429       74.31   -118.40
REMARK 500    ASN C 527     -140.59    -87.12
REMARK 500    CYS C 529      -20.59     71.58
REMARK 500
REMARK 500 REMARK: NULL
REMARK 600
REMARK 600 HETEROGEN
REMARK 600
REMARK 600 C9C HAS A BETAHYDROXY-COVALENT INTERMEDIATE STATE WITH SERINE225.
REMARK 610
REMARK 610 MISSING HETEROATOM
REMARK 610 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 610 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 610 I=INSERTION CODE):
REMARK 610   M RES C SSEQI
REMARK 610     C9C A  701
REMARK 610     C9C C  701
REMARK 620
REMARK 620 METAL COORDINATION
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA A 702  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 ASP A 304   O
REMARK 620 2 ASP A 304   OD1  68.7
REMARK 620 3 ASP A 307   OD1  68.7 128.2
REMARK 620 4 ASP A 307   OD2  78.4 141.3  49.6
REMARK 620 5 LEU A 309   O    84.0  80.9 121.9  75.8
REMARK 620 6 ASP A 311   OD1 142.8  74.5 144.2 132.7  85.4
REMARK 620 7 ILE A 313   O   105.5  87.9  76.4 121.1 161.7  77.6
REMARK 620 N                    1     2     3     4     5     6
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA B 702  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 ASP B 304   O
REMARK 620 2 ASP B 304   OD1  64.2
REMARK 620 3 ASP B 307   OD1  95.0 157.5
REMARK 620 4 LEU B 309   O    87.8  81.1 107.8
REMARK 620 5 ASP B 311   OD1 152.5  88.8 112.5  82.4
REMARK 620 6 ILE B 313   O    99.5  90.8  84.2 165.5  85.5
REMARK 620 N                    1     2     3     4     5
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA C 702  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 ASP C 304   O
REMARK 620 2 ASP C 304   OD2  71.1
REMARK 620 3 ASP C 307   OD1  76.2 144.9
REMARK 620 4 ASP C 307   OD2  64.9 122.9  48.3
REMARK 620 5 LEU C 309   O    85.9  85.4  80.1 124.1
REMARK 620 6 ASP C 311   OD1 144.2  74.1 134.5 146.2  83.2
REMARK 620 7 ILE C 313   O    96.5  77.5 119.1  73.5 160.8  83.8
REMARK 620 N                    1     2     3     4     5     6
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue C9C A 701
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CA A 702
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue C8X B 701
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CA B 702
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CA C 702
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for Di-peptide C9C C 701 and SER C
REMARK 800  225
DBREF1 6JTT A   17   603  UNP                  MHETH_IDESA
DBREF2 6JTT A     A0A0K8P8E7                         17         603
DBREF1 6JTT B   17   603  UNP                  MHETH_IDESA
DBREF2 6JTT B     A0A0K8P8E7                         17         603
DBREF1 6JTT C   17   603  UNP                  MHETH_IDESA
DBREF2 6JTT C     A0A0K8P8E7                         17         603
SEQADV 6JTT MET A   -9  UNP  A0A0K8P8E           INITIATING METHIONINE
SEQADV 6JTT MET A   -8  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT ILE A   -7  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT THR A   -6  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT LEU A   -5  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT ARG A   -4  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT LYS A   -3  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT LEU A   -2  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT PRO A   -1  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT LEU A    0  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT ALA A    1  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT VAL A    2  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT ALA A    3  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT VAL A    4  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT ALA A    5  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT ALA A    6  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT GLY A    7  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT VAL A    8  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT MET A    9  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT SER A   10  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT ALA A   11  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT GLN A   12  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT ALA A   13  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT MET A   14  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT ALA A   15  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT MET A   16  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT LEU A  604  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT GLU A  605  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT HIS A  606  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT HIS A  607  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT HIS A  608  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT HIS A  609  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT HIS A  610  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT HIS A  611  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT MET B   -9  UNP  A0A0K8P8E           INITIATING METHIONINE
SEQADV 6JTT MET B   -8  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT ILE B   -7  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT THR B   -6  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT LEU B   -5  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT ARG B   -4  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT LYS B   -3  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT LEU B   -2  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT PRO B   -1  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT LEU B    0  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT ALA B    1  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT VAL B    2  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT ALA B    3  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT VAL B    4  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT ALA B    5  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT ALA B    6  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT GLY B    7  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT VAL B    8  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT MET B    9  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT SER B   10  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT ALA B   11  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT GLN B   12  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT ALA B   13  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT MET B   14  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT ALA B   15  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT MET B   16  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT LEU B  604  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT GLU B  605  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT HIS B  606  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT HIS B  607  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT HIS B  608  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT HIS B  609  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT HIS B  610  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT HIS B  611  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT MET C   -9  UNP  A0A0K8P8E           INITIATING METHIONINE
SEQADV 6JTT MET C   -8  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT ILE C   -7  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT THR C   -6  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT LEU C   -5  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT ARG C   -4  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT LYS C   -3  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT LEU C   -2  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT PRO C   -1  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT LEU C    0  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT ALA C    1  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT VAL C    2  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT ALA C    3  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT VAL C    4  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT ALA C    5  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT ALA C    6  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT GLY C    7  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT VAL C    8  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT MET C    9  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT SER C   10  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT ALA C   11  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT GLN C   12  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT ALA C   13  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT MET C   14  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT ALA C   15  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT MET C   16  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT LEU C  604  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT GLU C  605  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT HIS C  606  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT HIS C  607  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT HIS C  608  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT HIS C  609  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT HIS C  610  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 6JTT HIS C  611  UNP  A0A0K8P8E           EXPRESSION TAG
SEQRES   1 A  621  MET MET ILE THR LEU ARG LYS LEU PRO LEU ALA VAL ALA
SEQRES   2 A  621  VAL ALA ALA GLY VAL MET SER ALA GLN ALA MET ALA MET
SEQRES   3 A  621  ALA CYS ALA GLY GLY GLY SER THR PRO LEU PRO LEU PRO
SEQRES   4 A  621  GLN GLN GLN PRO PRO GLN GLN GLU PRO PRO PRO PRO PRO
SEQRES   5 A  621  VAL PRO LEU ALA SER ARG ALA ALA CYS GLU ALA LEU LYS
SEQRES   6 A  621  ASP GLY ASN GLY ASP MET VAL TRP PRO ASN ALA ALA THR
SEQRES   7 A  621  VAL VAL GLU VAL ALA ALA TRP ARG ASP ALA ALA PRO ALA
SEQRES   8 A  621  THR ALA SER ALA ALA ALA LEU PRO GLU HIS CYS GLU VAL
SEQRES   9 A  621  SER GLY ALA ILE ALA LYS ARG THR GLY ILE ASP GLY TYR
SEQRES  10 A  621  PRO TYR GLU ILE LYS PHE ARG LEU ARG MET PRO ALA GLU
SEQRES  11 A  621  TRP ASN GLY ARG PHE PHE MET GLU GLY GLY SER GLY THR
SEQRES  12 A  621  ASN GLY SER LEU SER ALA ALA THR GLY SER ILE GLY GLY
SEQRES  13 A  621  GLY GLN ILE ALA SER ALA LEU SER ARG ASN PHE ALA THR
SEQRES  14 A  621  ILE ALA THR ASP GLY GLY HIS ASP ASN ALA VAL ASN ASP
SEQRES  15 A  621  ASN PRO ASP ALA LEU GLY THR VAL ALA PHE GLY LEU ASP
SEQRES  16 A  621  PRO GLN ALA ARG LEU ASP MET GLY TYR ASN SER TYR ASP
SEQRES  17 A  621  GLN VAL THR GLN ALA GLY LYS ALA ALA VAL ALA ARG PHE
SEQRES  18 A  621  TYR GLY ARG ALA ALA ASP LYS SER TYR PHE ILE GLY CYS
SEQRES  19 A  621  SER GLU GLY GLY ARG GLU GLY MET MET LEU SER GLN ARG
SEQRES  20 A  621  PHE PRO SER HIS TYR ASP GLY ILE VAL ALA GLY ALA PRO
SEQRES  21 A  621  GLY TYR GLN LEU PRO LYS ALA GLY ILE SER GLY ALA TRP
SEQRES  22 A  621  THR THR GLN SER LEU ALA PRO ALA ALA VAL GLY LEU ASP
SEQRES  23 A  621  ALA GLN GLY VAL PRO LEU ILE ASN LYS SER PHE SER ASP
SEQRES  24 A  621  ALA ASP LEU HIS LEU LEU SER GLN ALA ILE LEU GLY THR
SEQRES  25 A  621  CYS ASP ALA LEU ASP GLY LEU ALA ASP GLY ILE VAL ASP
SEQRES  26 A  621  ASN TYR ARG ALA CYS GLN ALA ALA PHE ASP PRO ALA THR
SEQRES  27 A  621  ALA ALA ASN PRO ALA ASN GLY GLN ALA LEU GLN CYS VAL
SEQRES  28 A  621  GLY ALA LYS THR ALA ASP CYS LEU SER PRO VAL GLN VAL
SEQRES  29 A  621  THR ALA ILE LYS ARG ALA MET ALA GLY PRO VAL ASN SER
SEQRES  30 A  621  ALA GLY THR PRO LEU TYR ASN ARG TRP ALA TRP ASP ALA
SEQRES  31 A  621  GLY MET SER GLY LEU SER GLY THR THR TYR ASN GLN GLY
SEQRES  32 A  621  TRP ARG SER TRP TRP LEU GLY SER PHE ASN SER SER ALA
SEQRES  33 A  621  ASN ASN ALA GLN ARG VAL SER GLY PHE SER ALA ARG SER
SEQRES  34 A  621  TRP LEU VAL ASP PHE ALA THR PRO PRO GLU PRO MET PRO
SEQRES  35 A  621  MET THR GLN VAL ALA ALA ARG MET MET LYS PHE ASP PHE
SEQRES  36 A  621  ASP ILE ASP PRO LEU LYS ILE TRP ALA THR SER GLY GLN
SEQRES  37 A  621  PHE THR GLN SER SER MET ASP TRP HIS GLY ALA THR SER
SEQRES  38 A  621  THR ASP LEU ALA ALA PHE ARG ASP ARG GLY GLY LYS MET
SEQRES  39 A  621  ILE LEU TYR HIS GLY MET SER ASP ALA ALA PHE SER ALA
SEQRES  40 A  621  LEU ASP THR ALA ASP TYR TYR GLU ARG LEU GLY ALA ALA
SEQRES  41 A  621  MET PRO GLY ALA ALA GLY PHE ALA ARG LEU PHE LEU VAL
SEQRES  42 A  621  PRO GLY MET ASN HIS CYS SER GLY GLY PRO GLY THR ASP
SEQRES  43 A  621  ARG PHE ASP MET LEU THR PRO LEU VAL ALA TRP VAL GLU
SEQRES  44 A  621  ARG GLY GLU ALA PRO ASP GLN ILE SER ALA TRP SER GLY
SEQRES  45 A  621  THR PRO GLY TYR PHE GLY VAL ALA ALA ARG THR ARG PRO
SEQRES  46 A  621  LEU CYS PRO TYR PRO GLN ILE ALA ARG TYR LYS GLY SER
SEQRES  47 A  621  GLY ASP ILE ASN THR GLU ALA ASN PHE ALA CYS ALA ALA
SEQRES  48 A  621  PRO PRO LEU GLU HIS HIS HIS HIS HIS HIS
SEQRES   1 B  621  MET MET ILE THR LEU ARG LYS LEU PRO LEU ALA VAL ALA
SEQRES   2 B  621  VAL ALA ALA GLY VAL MET SER ALA GLN ALA MET ALA MET
SEQRES   3 B  621  ALA CYS ALA GLY GLY GLY SER THR PRO LEU PRO LEU PRO
SEQRES   4 B  621  GLN GLN GLN PRO PRO GLN GLN GLU PRO PRO PRO PRO PRO
SEQRES   5 B  621  VAL PRO LEU ALA SER ARG ALA ALA CYS GLU ALA LEU LYS
SEQRES   6 B  621  ASP GLY ASN GLY ASP MET VAL TRP PRO ASN ALA ALA THR
SEQRES   7 B  621  VAL VAL GLU VAL ALA ALA TRP ARG ASP ALA ALA PRO ALA
SEQRES   8 B  621  THR ALA SER ALA ALA ALA LEU PRO GLU HIS CYS GLU VAL
SEQRES   9 B  621  SER GLY ALA ILE ALA LYS ARG THR GLY ILE ASP GLY TYR
SEQRES  10 B  621  PRO TYR GLU ILE LYS PHE ARG LEU ARG MET PRO ALA GLU
SEQRES  11 B  621  TRP ASN GLY ARG PHE PHE MET GLU GLY GLY SER GLY THR
SEQRES  12 B  621  ASN GLY SER LEU SER ALA ALA THR GLY SER ILE GLY GLY
SEQRES  13 B  621  GLY GLN ILE ALA SER ALA LEU SER ARG ASN PHE ALA THR
SEQRES  14 B  621  ILE ALA THR ASP GLY GLY HIS ASP ASN ALA VAL ASN ASP
SEQRES  15 B  621  ASN PRO ASP ALA LEU GLY THR VAL ALA PHE GLY LEU ASP
SEQRES  16 B  621  PRO GLN ALA ARG LEU ASP MET GLY TYR ASN SER TYR ASP
SEQRES  17 B  621  GLN VAL THR GLN ALA GLY LYS ALA ALA VAL ALA ARG PHE
SEQRES  18 B  621  TYR GLY ARG ALA ALA ASP LYS SER TYR PHE ILE GLY CYS
SEQRES  19 B  621  SER GLU GLY GLY ARG GLU GLY MET MET LEU SER GLN ARG
SEQRES  20 B  621  PHE PRO SER HIS TYR ASP GLY ILE VAL ALA GLY ALA PRO
SEQRES  21 B  621  GLY TYR GLN LEU PRO LYS ALA GLY ILE SER GLY ALA TRP
SEQRES  22 B  621  THR THR GLN SER LEU ALA PRO ALA ALA VAL GLY LEU ASP
SEQRES  23 B  621  ALA GLN GLY VAL PRO LEU ILE ASN LYS SER PHE SER ASP
SEQRES  24 B  621  ALA ASP LEU HIS LEU LEU SER GLN ALA ILE LEU GLY THR
SEQRES  25 B  621  CYS ASP ALA LEU ASP GLY LEU ALA ASP GLY ILE VAL ASP
SEQRES  26 B  621  ASN TYR ARG ALA CYS GLN ALA ALA PHE ASP PRO ALA THR
SEQRES  27 B  621  ALA ALA ASN PRO ALA ASN GLY GLN ALA LEU GLN CYS VAL
SEQRES  28 B  621  GLY ALA LYS THR ALA ASP CYS LEU SER PRO VAL GLN VAL
SEQRES  29 B  621  THR ALA ILE LYS ARG ALA MET ALA GLY PRO VAL ASN SER
SEQRES  30 B  621  ALA GLY THR PRO LEU TYR ASN ARG TRP ALA TRP ASP ALA
SEQRES  31 B  621  GLY MET SER GLY LEU SER GLY THR THR TYR ASN GLN GLY
SEQRES  32 B  621  TRP ARG SER TRP TRP LEU GLY SER PHE ASN SER SER ALA
SEQRES  33 B  621  ASN ASN ALA GLN ARG VAL SER GLY PHE SER ALA ARG SER
SEQRES  34 B  621  TRP LEU VAL ASP PHE ALA THR PRO PRO GLU PRO MET PRO
SEQRES  35 B  621  MET THR GLN VAL ALA ALA ARG MET MET LYS PHE ASP PHE
SEQRES  36 B  621  ASP ILE ASP PRO LEU LYS ILE TRP ALA THR SER GLY GLN
SEQRES  37 B  621  PHE THR GLN SER SER MET ASP TRP HIS GLY ALA THR SER
SEQRES  38 B  621  THR ASP LEU ALA ALA PHE ARG ASP ARG GLY GLY LYS MET
SEQRES  39 B  621  ILE LEU TYR HIS GLY MET SER ASP ALA ALA PHE SER ALA
SEQRES  40 B  621  LEU ASP THR ALA ASP TYR TYR GLU ARG LEU GLY ALA ALA
SEQRES  41 B  621  MET PRO GLY ALA ALA GLY PHE ALA ARG LEU PHE LEU VAL
SEQRES  42 B  621  PRO GLY MET ASN HIS CYS SER GLY GLY PRO GLY THR ASP
SEQRES  43 B  621  ARG PHE ASP MET LEU THR PRO LEU VAL ALA TRP VAL GLU
SEQRES  44 B  621  ARG GLY GLU ALA PRO ASP GLN ILE SER ALA TRP SER GLY
SEQRES  45 B  621  THR PRO GLY TYR PHE GLY VAL ALA ALA ARG THR ARG PRO
SEQRES  46 B  621  LEU CYS PRO TYR PRO GLN ILE ALA ARG TYR LYS GLY SER
SEQRES  47 B  621  GLY ASP ILE ASN THR GLU ALA ASN PHE ALA CYS ALA ALA
SEQRES  48 B  621  PRO PRO LEU GLU HIS HIS HIS HIS HIS HIS
SEQRES   1 C  621  MET MET ILE THR LEU ARG LYS LEU PRO LEU ALA VAL ALA
SEQRES   2 C  621  VAL ALA ALA GLY VAL MET SER ALA GLN ALA MET ALA MET
SEQRES   3 C  621  ALA CYS ALA GLY GLY GLY SER THR PRO LEU PRO LEU PRO
SEQRES   4 C  621  GLN GLN GLN PRO PRO GLN GLN GLU PRO PRO PRO PRO PRO
SEQRES   5 C  621  VAL PRO LEU ALA SER ARG ALA ALA CYS GLU ALA LEU LYS
SEQRES   6 C  621  ASP GLY ASN GLY ASP MET VAL TRP PRO ASN ALA ALA THR
SEQRES   7 C  621  VAL VAL GLU VAL ALA ALA TRP ARG ASP ALA ALA PRO ALA
SEQRES   8 C  621  THR ALA SER ALA ALA ALA LEU PRO GLU HIS CYS GLU VAL
SEQRES   9 C  621  SER GLY ALA ILE ALA LYS ARG THR GLY ILE ASP GLY TYR
SEQRES  10 C  621  PRO TYR GLU ILE LYS PHE ARG LEU ARG MET PRO ALA GLU
SEQRES  11 C  621  TRP ASN GLY ARG PHE PHE MET GLU GLY GLY SER GLY THR
SEQRES  12 C  621  ASN GLY SER LEU SER ALA ALA THR GLY SER ILE GLY GLY
SEQRES  13 C  621  GLY GLN ILE ALA SER ALA LEU SER ARG ASN PHE ALA THR
SEQRES  14 C  621  ILE ALA THR ASP GLY GLY HIS ASP ASN ALA VAL ASN ASP
SEQRES  15 C  621  ASN PRO ASP ALA LEU GLY THR VAL ALA PHE GLY LEU ASP
SEQRES  16 C  621  PRO GLN ALA ARG LEU ASP MET GLY TYR ASN SER TYR ASP
SEQRES  17 C  621  GLN VAL THR GLN ALA GLY LYS ALA ALA VAL ALA ARG PHE
SEQRES  18 C  621  TYR GLY ARG ALA ALA ASP LYS SER TYR PHE ILE GLY CYS
SEQRES  19 C  621  SER GLU GLY GLY ARG GLU GLY MET MET LEU SER GLN ARG
SEQRES  20 C  621  PHE PRO SER HIS TYR ASP GLY ILE VAL ALA GLY ALA PRO
SEQRES  21 C  621  GLY TYR GLN LEU PRO LYS ALA GLY ILE SER GLY ALA TRP
SEQRES  22 C  621  THR THR GLN SER LEU ALA PRO ALA ALA VAL GLY LEU ASP
SEQRES  23 C  621  ALA GLN GLY VAL PRO LEU ILE ASN LYS SER PHE SER ASP
SEQRES  24 C  621  ALA ASP LEU HIS LEU LEU SER GLN ALA ILE LEU GLY THR
SEQRES  25 C  621  CYS ASP ALA LEU ASP GLY LEU ALA ASP GLY ILE VAL ASP
SEQRES  26 C  621  ASN TYR ARG ALA CYS GLN ALA ALA PHE ASP PRO ALA THR
SEQRES  27 C  621  ALA ALA ASN PRO ALA ASN GLY GLN ALA LEU GLN CYS VAL
SEQRES  28 C  621  GLY ALA LYS THR ALA ASP CYS LEU SER PRO VAL GLN VAL
SEQRES  29 C  621  THR ALA ILE LYS ARG ALA MET ALA GLY PRO VAL ASN SER
SEQRES  30 C  621  ALA GLY THR PRO LEU TYR ASN ARG TRP ALA TRP ASP ALA
SEQRES  31 C  621  GLY MET SER GLY LEU SER GLY THR THR TYR ASN GLN GLY
SEQRES  32 C  621  TRP ARG SER TRP TRP LEU GLY SER PHE ASN SER SER ALA
SEQRES  33 C  621  ASN ASN ALA GLN ARG VAL SER GLY PHE SER ALA ARG SER
SEQRES  34 C  621  TRP LEU VAL ASP PHE ALA THR PRO PRO GLU PRO MET PRO
SEQRES  35 C  621  MET THR GLN VAL ALA ALA ARG MET MET LYS PHE ASP PHE
SEQRES  36 C  621  ASP ILE ASP PRO LEU LYS ILE TRP ALA THR SER GLY GLN
SEQRES  37 C  621  PHE THR GLN SER SER MET ASP TRP HIS GLY ALA THR SER
SEQRES  38 C  621  THR ASP LEU ALA ALA PHE ARG ASP ARG GLY GLY LYS MET
SEQRES  39 C  621  ILE LEU TYR HIS GLY MET SER ASP ALA ALA PHE SER ALA
SEQRES  40 C  621  LEU ASP THR ALA ASP TYR TYR GLU ARG LEU GLY ALA ALA
SEQRES  41 C  621  MET PRO GLY ALA ALA GLY PHE ALA ARG LEU PHE LEU VAL
SEQRES  42 C  621  PRO GLY MET ASN HIS CYS SER GLY GLY PRO GLY THR ASP
SEQRES  43 C  621  ARG PHE ASP MET LEU THR PRO LEU VAL ALA TRP VAL GLU
SEQRES  44 C  621  ARG GLY GLU ALA PRO ASP GLN ILE SER ALA TRP SER GLY
SEQRES  45 C  621  THR PRO GLY TYR PHE GLY VAL ALA ALA ARG THR ARG PRO
SEQRES  46 C  621  LEU CYS PRO TYR PRO GLN ILE ALA ARG TYR LYS GLY SER
SEQRES  47 C  621  GLY ASP ILE ASN THR GLU ALA ASN PHE ALA CYS ALA ALA
SEQRES  48 C  621  PRO PRO LEU GLU HIS HIS HIS HIS HIS HIS
HET    C9C  A 701      14
HET     CA  A 702       1
HET    C8X  B 701      18
HET     CA  B 702       1
HET    C9C  C 701      14
HET     CA  C 702       1
HETNAM     C9C 4-(2-HYDROXYETHYLOXYCARBONYL)BENZOIC ACID
HETNAM      CA CALCIUM ION
HETNAM     C8X BIS(2-HYDROXYETHYL) BENZENE-1,4-DICARBOXYLATE
HETSYN     C9C MONOHYDROXYETHYL TEREPHTHALATE
HETSYN     C8X BIS(2-HYDROXYETHYL) TEREPHTHALATE
FORMUL   4  C9C    2(C10 H10 O5)
FORMUL   5   CA    3(CA 2+)
FORMUL   6  C8X    C12 H14 O6
FORMUL  10  HOH   *500(H2 O)
HELIX    1 AA1 SER A   47  ALA A   53  1                                   7
HELIX    2 AA2 ALA A  152  ASN A  156  5                                   5
HELIX    3 AA3 LEU A  177  LEU A  184  5                                   8
HELIX    4 AA4 ASP A  185  TYR A  194  1                                  10
HELIX    5 AA5 TYR A  194  GLY A  213  1                                  20
HELIX    6 AA6 SER A  225  PHE A  238  1                                  14
HELIX    7 AA7 GLN A  253  PRO A  255  5                                   3
HELIX    8 AA8 LYS A  256  ALA A  269  1                                  14
HELIX    9 AA9 PRO A  270  ALA A  272  5                                   3
HELIX   10 AB1 LEU A  282  PHE A  287  5                                   6
HELIX   11 AB2 SER A  288  ASP A  304  1                                  17
HELIX   12 AB3 ALA A  305  GLY A  308  5                                   4
HELIX   13 AB4 ASN A  316  PHE A  324  1                                   9
HELIX   14 AB5 SER A  350  GLY A  363  1                                  14
HELIX   15 AB6 ASP A  379  SER A  383  5                                   5
HELIX   16 AB7 GLY A  414  PHE A  424  1                                  11
HELIX   17 AB8 PRO A  432  THR A  434  5                                   3
HELIX   18 AB9 GLN A  435  LYS A  442  1                                   8
HELIX   19 AC1 ILE A  447  TRP A  453  5                                   7
HELIX   20 AC2 SER A  462  HIS A  467  1                                   6
HELIX   21 AC3 LEU A  474  ARG A  480  1                                   7
HELIX   22 AC4 SER A  496  MET A  511  1                                  16
HELIX   23 AC5 GLY A  513  GLY A  516  5                                   4
HELIX   24 AC6 MET A  540  GLY A  551  1                                  12
HELIX   25 AC7 THR A  563  GLY A  568  5                                   6
HELIX   26 AC8 THR A  593  ALA A  595  5                                   3
HELIX   27 AC9 SER B   47  ALA B   53  1                                   7
HELIX   28 AD1 LEU B  177  LEU B  184  5                                   8
HELIX   29 AD2 ASP B  185  TYR B  194  1                                  10
HELIX   30 AD3 TYR B  194  GLY B  213  1                                  20
HELIX   31 AD4 SER B  225  PHE B  238  1                                  14
HELIX   32 AD5 GLN B  253  PRO B  255  5                                   3
HELIX   33 AD6 LYS B  256  ALA B  269  1                                  14
HELIX   34 AD7 PRO B  270  ALA B  272  5                                   3
HELIX   35 AD8 LEU B  282  SER B  286  5                                   5
HELIX   36 AD9 SER B  288  ASP B  304  1                                  17
HELIX   37 AE1 ALA B  305  GLY B  308  5                                   4
HELIX   38 AE2 ASN B  316  PHE B  324  1                                   9
HELIX   39 AE3 SER B  350  GLY B  363  1                                  14
HELIX   40 AE4 ASP B  379  SER B  383  5                                   5
HELIX   41 AE5 GLY B  414  PHE B  424  1                                  11
HELIX   42 AE6 PRO B  432  THR B  434  5                                   3
HELIX   43 AE7 GLN B  435  PHE B  443  1                                   9
HELIX   44 AE8 ILE B  447  TRP B  453  5                                   7
HELIX   45 AE9 SER B  462  HIS B  467  1                                   6
HELIX   46 AF1 LEU B  474  ARG B  480  1                                   7
HELIX   47 AF2 SER B  496  MET B  511  1                                  16
HELIX   48 AF3 GLY B  513  GLY B  516  5                                   4
HELIX   49 AF4 MET B  540  GLY B  551  1                                  12
HELIX   50 AF5 THR B  563  GLY B  568  5                                   6
HELIX   51 AF6 THR B  593  ALA B  595  5                                   3
HELIX   52 AF7 SER C   47  ALA C   53  1                                   7
HELIX   53 AF8 LEU C  177  LEU C  184  5                                   8
HELIX   54 AF9 ASP C  185  TYR C  194  1                                  10
HELIX   55 AG1 TYR C  194  GLY C  213  1                                  20
HELIX   56 AG2 SER C  225  PHE C  238  1                                  14
HELIX   57 AG3 GLN C  253  PRO C  255  5                                   3
HELIX   58 AG4 LYS C  256  ALA C  269  1                                  14
HELIX   59 AG5 PRO C  270  ALA C  272  5                                   3
HELIX   60 AG6 LEU C  282  PHE C  287  5                                   6
HELIX   61 AG7 SER C  288  ASP C  304  1                                  17
HELIX   62 AG8 ALA C  305  GLY C  308  5                                   4
HELIX   63 AG9 ASN C  316  PHE C  324  1                                   9
HELIX   64 AH1 SER C  350  GLY C  363  1                                  14
HELIX   65 AH2 ASP C  379  SER C  383  5                                   5
HELIX   66 AH3 GLY C  414  PHE C  424  1                                  11
HELIX   67 AH4 PRO C  432  THR C  434  5                                   3
HELIX   68 AH5 GLN C  435  LYS C  442  1                                   8
HELIX   69 AH6 ILE C  447  TRP C  453  5                                   7
HELIX   70 AH7 SER C  462  HIS C  467  1                                   6
HELIX   71 AH8 LEU C  474  ARG C  480  1                                   7
HELIX   72 AH9 SER C  496  MET C  511  1                                  16
HELIX   73 AI1 GLY C  513  GLY C  516  5                                   4
HELIX   74 AI2 MET C  540  GLY C  551  1                                  12
HELIX   75 AI3 THR C  563  GLY C  568  5                                   6
HELIX   76 AI4 THR C  593  ALA C  595  5                                   3
SHEET    1 AA1 9 THR A  68  ARG A  76  0
SHEET    2 AA1 9 HIS A  91  THR A 102 -1  O  GLU A  93   N  ALA A  74
SHEET    3 AA1 9 PRO A 108  PRO A 118 -1  O  LEU A 115   N  VAL A  94
SHEET    4 AA1 9 ALA A 158  THR A 162 -1  O  THR A 159   N  ARG A 116
SHEET    5 AA1 9 ARG A 124  GLU A 128  1  N  ARG A 124   O  ALA A 158
SHEET    6 AA1 9 LYS A 218  CYS A 224  1  O  TYR A 220   N  MET A 127
SHEET    7 AA1 9 GLY A 244  GLY A 248  1  O  GLY A 244   N  PHE A 221
SHEET    8 AA1 9 LYS A 483  GLY A 489  1  O  ILE A 485   N  ALA A 247
SHEET    9 AA1 9 ALA A 518  VAL A 523  1  O  VAL A 523   N  HIS A 488
SHEET    1 AA2 2 LEU A 385  SER A 386  0
SHEET    2 AA2 2 THR A 389  TYR A 390 -1  O  THR A 389   N  SER A 386
SHEET    1 AA3 2 ILE A 557  TRP A 560  0
SHEET    2 AA3 2 THR A 573  LEU A 576 -1  O  LEU A 576   N  ILE A 557
SHEET    1 AA4 2 ILE A 582  TYR A 585  0
SHEET    2 AA4 2 PHE A 597  ALA A 600 -1  O  ALA A 598   N  ARG A 584
SHEET    1 AA5 9 THR B  68  ARG B  76  0
SHEET    2 AA5 9 HIS B  91  THR B 102 -1  O  GLU B  93   N  ALA B  74
SHEET    3 AA5 9 PRO B 108  PRO B 118 -1  O  LEU B 115   N  VAL B  94
SHEET    4 AA5 9 ALA B 158  THR B 162 -1  O  THR B 159   N  ARG B 116
SHEET    5 AA5 9 ARG B 124  GLU B 128  1  N  ARG B 124   O  ALA B 158
SHEET    6 AA5 9 LYS B 218  CYS B 224  1  O  TYR B 220   N  PHE B 125
SHEET    7 AA5 9 GLY B 244  GLY B 248  1  O  GLY B 248   N  GLY B 223
SHEET    8 AA5 9 LYS B 483  GLY B 489  1  O  ILE B 485   N  ILE B 245
SHEET    9 AA5 9 ALA B 518  VAL B 523  1  O  ARG B 519   N  LEU B 486
SHEET    1 AA6 2 LEU B 385  SER B 386  0
SHEET    2 AA6 2 THR B 389  TYR B 390 -1  O  THR B 389   N  SER B 386
SHEET    1 AA7 2 ILE B 557  TRP B 560  0
SHEET    2 AA7 2 THR B 573  LEU B 576 -1  O  LEU B 576   N  ILE B 557
SHEET    1 AA8 2 ILE B 582  TYR B 585  0
SHEET    2 AA8 2 PHE B 597  ALA B 600 -1  O  ALA B 600   N  ILE B 582
SHEET    1 AA9 9 THR C  68  ARG C  76  0
SHEET    2 AA9 9 HIS C  91  THR C 102 -1  O  GLU C  93   N  ALA C  74
SHEET    3 AA9 9 PRO C 108  PRO C 118 -1  O  LEU C 115   N  VAL C  94
SHEET    4 AA9 9 ALA C 158  THR C 162 -1  O  THR C 159   N  ARG C 116
SHEET    5 AA9 9 ARG C 124  GLU C 128  1  N  PHE C 126   O  ALA C 158
SHEET    6 AA9 9 LYS C 218  CYS C 224  1  O  TYR C 220   N  PHE C 125
SHEET    7 AA9 9 GLY C 244  GLY C 248  1  O  GLY C 248   N  GLY C 223
SHEET    8 AA9 9 LYS C 483  GLY C 489  1  O  ILE C 485   N  ILE C 245
SHEET    9 AA9 9 ALA C 518  VAL C 523  1  O  ARG C 519   N  LEU C 486
SHEET    1 AB1 2 LEU C 385  SER C 386  0
SHEET    2 AB1 2 THR C 389  TYR C 390 -1  O  THR C 389   N  SER C 386
SHEET    1 AB2 2 ILE C 557  TRP C 560  0
SHEET    2 AB2 2 THR C 573  LEU C 576 -1  O  LEU C 576   N  ILE C 557
SHEET    1 AB3 2 ILE C 582  TYR C 585  0
SHEET    2 AB3 2 PHE C 597  ALA C 600 -1  O  ALA C 600   N  ILE C 582
SSBOND   1 CYS A   51    CYS A   92                          1555   1555  2.04
SSBOND   2 CYS A  224    CYS A  529                          1555   1555  2.06
SSBOND   3 CYS A  303    CYS A  320                          1555   1555  2.12
SSBOND   4 CYS A  340    CYS A  348                          1555   1555  2.07
SSBOND   5 CYS A  577    CYS A  599                          1555   1555  2.01
SSBOND   6 CYS B   51    CYS B   92                          1555   1555  2.16
SSBOND   7 CYS B  224    CYS B  529                          1555   1555  2.09
SSBOND   8 CYS B  303    CYS B  320                          1555   1555  2.07
SSBOND   9 CYS B  340    CYS B  348                          1555   1555  1.84
SSBOND  10 CYS B  577    CYS B  599                          1555   1555  2.02
SSBOND  11 CYS C   51    CYS C   92                          1555   1555  2.16
SSBOND  12 CYS C  224    CYS C  529                          1555   1555  2.08
SSBOND  13 CYS C  303    CYS C  320                          1555   1555  2.09
SSBOND  14 CYS C  340    CYS C  348                          1555   1555  2.06
SSBOND  15 CYS C  577    CYS C  599                          1555   1555  2.02
LINK         O   ASP A 304                CA    CA A 702     1555   1555  2.35
LINK         OD1 ASP A 304                CA    CA A 702     1555   1555  2.31
LINK         OD1 ASP A 307                CA    CA A 702     1555   1555  2.88
LINK         OD2 ASP A 307                CA    CA A 702     1555   1555  2.32
LINK         O   LEU A 309                CA    CA A 702     1555   1555  2.33
LINK         OD1 ASP A 311                CA    CA A 702     1555   1555  2.35
LINK         O   ILE A 313                CA    CA A 702     1555   1555  2.32
LINK         O   ASP B 304                CA    CA B 702     1555   1555  2.36
LINK         OD1 ASP B 304                CA    CA B 702     1555   1555  2.27
LINK         OD1 ASP B 307                CA    CA B 702     1555   1555  2.21
LINK         O   LEU B 309                CA    CA B 702     1555   1555  2.31
LINK         OD1 ASP B 311                CA    CA B 702     1555   1555  2.33
LINK         O   ILE B 313                CA    CA B 702     1555   1555  2.31
LINK         O   ASP C 304                CA    CA C 702     1555   1555  2.32
LINK         OD2 ASP C 304                CA    CA C 702     1555   1555  2.33
LINK         OD1 ASP C 307                CA    CA C 702     1555   1555  2.36
LINK         OD2 ASP C 307                CA    CA C 702     1555   1555  2.92
LINK         O   LEU C 309                CA    CA C 702     1555   1555  2.31
LINK         OD1 ASP C 311                CA    CA C 702     1555   1555  2.38
LINK         O   ILE C 313                CA    CA C 702     1555   1555  2.32
CISPEP   1 THR A  426    PRO A  427          0        -8.73
CISPEP   2 TYR A  579    PRO A  580          0         4.81
CISPEP   3 THR B  426    PRO B  427          0        -4.16
CISPEP   4 TYR B  579    PRO B  580          0         0.41
CISPEP   5 THR C  426    PRO C  427          0        -9.25
CISPEP   6 TYR C  579    PRO C  580          0        -0.94
SITE     1 AC1 13 GLY A 132  SER A 225  GLU A 226  LEU A 254
SITE     2 AC1 13 ALA A 257  GLY A 258  TRP A 397  ARG A 411
SITE     3 AC1 13 PHE A 415  SER A 416  PHE A 424  PHE A 495
SITE     4 AC1 13 HIS A 528
SITE     1 AC2  6 ASP A 304  ASP A 307  LEU A 309  ASP A 311
SITE     2 AC2  6 ILE A 313  HOH A 801
SITE     1 AC3 15 GLY B 132  SER B 225  GLU B 226  LEU B 254
SITE     2 AC3 15 ALA B 257  GLY B 258  TRP B 397  ARG B 411
SITE     3 AC3 15 PHE B 415  SER B 416  TRP B 420  PHE B 424
SITE     4 AC3 15 PHE B 495  HIS B 528  HOH B 910
SITE     1 AC4  6 ASP B 304  ASP B 307  LEU B 309  ASP B 311
SITE     2 AC4  6 ILE B 313  HOH B 801
SITE     1 AC5  6 ASP C 304  ASP C 307  LEU C 309  ASP C 311
SITE     2 AC5  6 ILE C 313  HOH C 809
SITE     1 AC6 23 GLY C 132  CYS C 224  GLU C 226  GLY C 227
SITE     2 AC6 23 GLY C 228  ARG C 229  GLY C 248  ALA C 249
SITE     3 AC6 23 PRO C 250  GLY C 251  LEU C 254  ALA C 257
SITE     4 AC6 23 GLY C 258  TRP C 397  ARG C 411  PHE C 415
SITE     5 AC6 23 SER C 416  TRP C 420  PHE C 424  PHE C 495
SITE     6 AC6 23 HIS C 528  CYS C 529  HOH C 901
CRYST1  215.259  173.799  106.671  90.00 119.51  90.00 C 1 2 1      12
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.004646  0.000000  0.002629        0.00000
SCALE2      0.000000  0.005754  0.000000        0.00000
SCALE3      0.000000  0.000000  0.010772        0.00000
TER    4144      PRO A 603
TER    8277      LEU B 604
TER   12405      PRO C 603
MASTER      624    0    6   76   45    0   20    612918    3  102  144
END