longtext: 6n5g-pdb

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HEADER    HYDROLASE/INHIBITOR                     21-NOV-18   6N5G
TITLE     CRYSTAL STRUCTURE OF AN EPOXIDE HYDROLASE FROM TRICHODERMA REESEI IN
TITLE    2 COMPLEX WITH INHIBITOR 2
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: EPOXIDE HYDROLASE TREH;
COMPND   3 CHAIN: A;
COMPND   4 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: TRICHODERMA REESEI QM9414;
SOURCE   3 ORGANISM_TAXID: 334564;
SOURCE   4 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21;
SOURCE   5 EXPRESSION_SYSTEM_TAXID: 511693
KEYWDS    TRICHODERMA REESEI, EPOXIDE HYDROLASE, INHIBITOR, HYDROLASE,
KEYWDS   2 HYDROLASE-INHIBITOR COMPLEX
EXPDTA    X-RAY DIFFRACTION
AUTHOR    G.S.OLIVEIRA,P.P.ADRIANI,J.A.RIBEIRO,C.MORISSEAU,B.D.HAMMOCK,
AUTHOR   2 M.V.DIAS,F.S.CHAMBERGO
REVDAT   1   20-NOV-19 6N5G    0
JRNL        AUTH   G.S.DE OLIVEIRA,P.P.ADRIANI,J.A.RIBEIRO,C.MORISSEAU,
JRNL        AUTH 2 B.D.HAMMOCK,M.V.B.DIAS,F.S.CHAMBERGO
JRNL        TITL   THE MOLECULAR STRUCTURE OF AN EPOXIDE HYDROLASE FROM
JRNL        TITL 2 TRICHODERMA REESEI IN COMPLEX WITH UREA OR AMIDE-BASED
JRNL        TITL 3 INHIBITORS.
JRNL        REF    INT. J. BIOL. MACROMOL.       V. 129   653 2019
JRNL        REFN                   ISSN 1879-0003
JRNL        PMID   30771398
JRNL        DOI    10.1016/J.IJBIOMAC.2019.02.070
REMARK   2
REMARK   2 RESOLUTION.    2.60 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX 1.10.1_2155
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : NULL
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.60
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 37.81
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.340
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.0
REMARK   3   NUMBER OF REFLECTIONS             : 10828
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.273
REMARK   3   R VALUE            (WORKING SET) : 0.270
REMARK   3   FREE R VALUE                     : 0.340
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.720
REMARK   3   FREE R VALUE TEST SET COUNT      : 511
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 37.8179 -  4.1261    0.98     2687   126  0.2560 0.2917
REMARK   3     2  4.1261 -  3.2756    0.99     2542   141  0.2493 0.3479
REMARK   3     3  3.2756 -  2.8617    0.99     2560   107  0.2903 0.3768
REMARK   3     4  2.8617 -  2.6001    0.99     2528   137  0.3172 0.3907
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : NULL
REMARK   3   SOLVENT RADIUS     : 1.11
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.440
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 37.870
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 24.54
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 24.91
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :  0.004           2743
REMARK   3   ANGLE     :  0.760           3726
REMARK   3   CHIRALITY :  0.042            386
REMARK   3   PLANARITY :  0.007            487
REMARK   3   DIHEDRAL  : 17.032           1621
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 6N5G COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 26-NOV-18.
REMARK 100 THE DEPOSITION ID IS D_1000238215.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 10-OCT-17
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : NULL
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : LNLS
REMARK 200  BEAMLINE                       : W01B-MX2
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.48
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : PIXEL
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS PILATUS3 2M
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200  DATA SCALING SOFTWARE          : AIMLESS 0.5.27
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 10961
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.600
REMARK 200  RESOLUTION RANGE LOW       (A) : 38.660
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 100.0
REMARK 200  DATA REDUNDANCY                : 12.40
REMARK 200  R MERGE                    (I) : 0.28100
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 7.5000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.60
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.72
REMARK 200  COMPLETENESS FOR SHELL     (%) : 100.0
REMARK 200  DATA REDUNDANCY IN SHELL       : 13.10
REMARK 200  R MERGE FOR SHELL          (I) : 1.01900
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: 5URO
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 45.37
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.25
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 50 MM 3-MORPHOLINOPROPANE-1-SULFONIC
REMARK 280  ACID (MOPS) PH 6.5, 40 MM POTASSIUM BROMIDE AND 44.6% PEG 4000,
REMARK 280  VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 300K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 2 21 21
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   X,-Y,-Z
REMARK 290       3555   -X,Y+1/2,-Z+1/2
REMARK 290       4555   -X,-Y+1/2,Z+1/2
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       38.66150
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       43.35150
REMARK 290   SMTRY1   4 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       38.66150
REMARK 290   SMTRY3   4  0.000000  0.000000  1.000000       43.35150
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     GLU A 227    CG   CD   OE1  OE2
REMARK 470     LYS A 295    CG   CD   CE   NZ
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   O    PRO A   291     OG   SER A   294              2.14
REMARK 500   OG1  THR A   312     OE1  GLN A   318              2.17
REMARK 500   OE2  GLU A   322     O    HOH A   501              2.19
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    ASP A 226   CB  -  CG  -  OD1 ANGL. DEV. =  -5.4 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    ASP A  48     -155.00    -87.88
REMARK 500    ALA A  76     -130.80     63.39
REMARK 500    ASP A 116     -120.73     63.78
REMARK 500    GLU A 131       -9.64    -59.79
REMARK 500    CYS A 140      -36.90     72.48
REMARK 500    PHE A 194       40.43   -105.06
REMARK 500    ASP A 226     -170.23    -68.43
REMARK 500    LEU A 272       97.24    -63.47
REMARK 500    ASP A 286       83.37    -63.28
REMARK 500    LYS A 295     -122.43     42.29
REMARK 500    ASP A 303       87.64   -152.16
REMARK 500    ASP A 310       89.52    -65.41
REMARK 500
REMARK 500 REMARK: NULL
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue KDS A 401
DBREF  6N5G A    1   336  PDB    6N5G     6N5G             1    336
SEQRES   1 A  336  MET ASP THR SER LYS LEU LYS PRO ASN ASP PRO ARG VAL
SEQRES   2 A  336  LYS TYR GLU THR LYS GLN ILE ARG GLY LYS THR TYR SER
SEQRES   3 A  336  TYR ILE LEU GLY GLU PRO ALA GLY PRO LYS LEU GLU THR
SEQRES   4 A  336  VAL VAL LEU VAL HIS GLY TRP PRO ASP MET ALA PHE GLY
SEQRES   5 A  336  TRP ARG HIS GLN ILE PRO TYR LEU MET SER LEU GLY PHE
SEQRES   6 A  336  GLN VAL VAL ALA PRO ASN MET LEU GLY TYR ALA GLY THR
SEQRES   7 A  336  ASP ALA PRO ARG ASP LEU SER GLN PHE THR LEU LYS SER
SEQRES   8 A  336  VAL SER ALA ASP ILE ALA GLU LEU ALA ARG SER PHE VAL
SEQRES   9 A  336  GLY GLN ASP GLY GLN ILE VAL LEU GLY GLY HIS ASP TRP
SEQRES  10 A  336  GLY GLY ALA VAL VAL TRP ARG THR ALA TYR TYR HIS PRO
SEQRES  11 A  336  GLU LEU VAL LYS ALA VAL PHE SER VAL CYS THR PRO LEU
SEQRES  12 A  336  HIS PRO LEU SER ALA GLU TYR LYS PRO LEU GLU ASP ILE
SEQRES  13 A  336  VAL ALA ALA GLY HIS MET LEU ASN PHE LYS TYR GLN LEU
SEQRES  14 A  336  GLN LEU LYS GLY PRO ASP VAL GLU ALA ARG ILE GLN GLY
SEQRES  15 A  336  LYS ASP MET LEU ARG ARG PHE PHE ARG ALA MET PHE GLY
SEQRES  16 A  336  GLY ARG GLY PRO ASN GLY GLU ALA GLY PHE SER THR SER
SEQRES  17 A  336  ASP GLY VAL HIS PHE ASP VAL LEU ASP LYS ILE GLY ALA
SEQRES  18 A  336  PRO PRO LEU LEU ASP GLU GLN GLU LEU GLU TYR TYR VAL
SEQRES  19 A  336  GLU GLN TYR ALA LEU GLN GLU ALA PRO GLU LEU ARG GLY
SEQRES  20 A  336  PRO LEU ASN TRP TYR ARG THR ARG GLU LEU ASN ALA LYS
SEQRES  21 A  336  ASP GLU MET ASP ARG ALA LYS ASN GLY PRO PRO LEU ARG
SEQRES  22 A  336  PHE GLU MET PRO ALA LEU PHE VAL ALA ALA SER LYS ASP
SEQRES  23 A  336  ASN ALA LEU PRO PRO ALA MET SER LYS GLY MET ASP ALA
SEQRES  24 A  336  PHE TYR LYS ASP LEU THR ARG ALA GLU VAL ASP ALA THR
SEQRES  25 A  336  HIS TRP ALA LEU THR GLN ALA GLY ASP GLU VAL ASN ARG
SEQRES  26 A  336  VAL ILE GLY GLU TRP LEU ASN LYS ALA LEU GLY
HET    KDS  A 401      31
HETNAM     KDS 4-[(QUINOLIN-3-YL)METHYL]-N-[4-(TRIFLUOROMETHOXY)
HETNAM   2 KDS  PHENYL]PIPERIDINE-1-CARBOXAMIDE
FORMUL   2  KDS    C23 H22 F3 N3 O2
FORMUL   3  HOH   *22(H2 O)
HELIX    1 AA1 MET A   49  ARG A   54  5                                   6
HELIX    2 AA2 GLN A   56  LEU A   63  1                                   8
HELIX    3 AA3 ASP A   83  PHE A   87  5                                   5
HELIX    4 AA4 THR A   88  GLY A  105  1                                  18
HELIX    5 AA5 ASP A  116  HIS A  129  1                                  14
HELIX    6 AA6 PRO A  152  ALA A  159  1                                   8
HELIX    7 AA7 MET A  162  LYS A  166  5                                   5
HELIX    8 AA8 TYR A  167  GLY A  173  1                                   7
HELIX    9 AA9 PRO A  174  ILE A  180  1                                   7
HELIX   10 AB1 GLN A  181  PHE A  194  1                                  14
HELIX   11 AB2 ASP A  226  ALA A  238  1                                  13
HELIX   12 AB3 LEU A  245  TRP A  251  1                                   7
HELIX   13 AB4 THR A  254  ASN A  268  1                                  15
HELIX   14 AB5 SER A  294  TYR A  301  5                                   8
HELIX   15 AB6 TRP A  314  ALA A  319  1                                   6
HELIX   16 AB7 ALA A  319  LEU A  335  1                                  17
SHEET    1 AA1 8 LYS A  14  ILE A  20  0
SHEET    2 AA1 8 LYS A  23  GLY A  30 -1  O  LEU A  29   N  LYS A  14
SHEET    3 AA1 8 GLN A  66  PRO A  70 -1  O  VAL A  67   N  GLY A  30
SHEET    4 AA1 8 THR A  39  VAL A  43  1  N  VAL A  40   O  GLN A  66
SHEET    5 AA1 8 ILE A 110  HIS A 115  1  O  GLY A 113   N  VAL A  41
SHEET    6 AA1 8 VAL A 133  VAL A 139  1  O  PHE A 137   N  LEU A 112
SHEET    7 AA1 8 ALA A 278  LYS A 285  1  O  VAL A 281   N  SER A 138
SHEET    8 AA1 8 LEU A 304  THR A 312  1  O  THR A 305   N  ALA A 278
SHEET    1 AA2 2 PHE A 205  SER A 206  0
SHEET    2 AA2 2 GLY A 210  VAL A 211 -1  O  GLY A 210   N  SER A 206
CISPEP   1 TRP A   46    PRO A   47          0        -9.85
CISPEP   2 ALA A  242    PRO A  243          0        -7.50
SITE     1 AC1 14 TRP A  46  ASP A 116  TRP A 117  ALA A 120
SITE     2 AC1 14 HIS A 144  TYR A 167  GLN A 168  MET A 193
SITE     3 AC1 14 PHE A 205  TYR A 252  ALA A 288  LEU A 289
SITE     4 AC1 14 HIS A 313  TRP A 314
CRYST1   50.420   77.323   86.703  90.00  90.00  90.00 P 2 21 21     4
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.019833  0.000000  0.000000        0.00000
SCALE2      0.000000  0.012933  0.000000        0.00000
SCALE3      0.000000  0.000000  0.011534        0.00000
TER    2638      GLY A 336
MASTER      266    0    1   16   10    0    4    6 2690    1   31   26
END