longtext: 6ne9-pdb

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HEADER    HYDROLASE                               17-DEC-18   6NE9
TITLE     BACTEROIDES INTESTINALIS ACETYL XYLAN ESTERASE (BACINT_01039)
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: ISOAMYLASE PROTEIN;
COMPND   3 CHAIN: A, B;
COMPND   4 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: BACTEROIDES INTESTINALIS;
SOURCE   3 ORGANISM_TAXID: 329854;
SOURCE   4 GENE: HMPREF2531_02003;
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 562
KEYWDS    CARBOHYDRATE ESTERASE FAMILY 1, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    N.M.KOROPATKIN,G.V.PEREIRA,I.CANN
REVDAT   1   25-DEC-19 6NE9    0
JRNL        AUTH   G.V.PEREIRA,C.DALESSANDRO-GABAZZA,J.FARRIS,D.WEFERS,
JRNL        AUTH 2 R.MACKIE,N.M.KOROPATKIN,E.C.GABAZZA,I.CANN
JRNL        TITL   COMPLEX ARABINOXYLAN FERMENTING BACTEROIDETES RELEASE
JRNL        TITL 2 DIETARY ANTIOXIDANTS THAT IMPACT HOST IMMUNE FUNCTION
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   2
REMARK   2 RESOLUTION.    1.74 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX 1.9_1692
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : NULL
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.74
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 28.60
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.370
REMARK   3   COMPLETENESS FOR RANGE        (%) : 91.7
REMARK   3   NUMBER OF REFLECTIONS             : 76952
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.185
REMARK   3   R VALUE            (WORKING SET) : 0.183
REMARK   3   FREE R VALUE                     : 0.217
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.010
REMARK   3   FREE R VALUE TEST SET COUNT      : 3859
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 28.6014 -  5.2673    1.00     2995   187  0.2035 0.1987
REMARK   3     2  5.2673 -  4.1850    0.98     2867   162  0.1518 0.1976
REMARK   3     3  4.1850 -  3.6572    1.00     2870   159  0.1554 0.1846
REMARK   3     4  3.6572 -  3.3234    1.00     2894   122  0.1575 0.1943
REMARK   3     5  3.3234 -  3.0855    1.00     2876   144  0.1685 0.1984
REMARK   3     6  3.0855 -  2.9037    1.00     2863   155  0.1700 0.2191
REMARK   3     7  2.9037 -  2.7584    1.00     2847   151  0.1671 0.1932
REMARK   3     8  2.7584 -  2.6385    1.00     2826   161  0.1695 0.1993
REMARK   3     9  2.6385 -  2.5370    1.00     2827   165  0.1720 0.2187
REMARK   3    10  2.5370 -  2.4495    1.00     2820   157  0.1825 0.2237
REMARK   3    11  2.4495 -  2.3729    0.99     2813   168  0.1865 0.2413
REMARK   3    12  2.3729 -  2.3051    1.00     2814   166  0.1836 0.2085
REMARK   3    13  2.3051 -  2.2444    1.00     2826   143  0.1847 0.2372
REMARK   3    14  2.2444 -  2.1897    1.00     2813   153  0.1934 0.2440
REMARK   3    15  2.1897 -  2.1399    1.00     2846   158  0.1943 0.2216
REMARK   3    16  2.1399 -  2.0944    1.00     2832   129  0.1946 0.2442
REMARK   3    17  2.0944 -  2.0525    1.00     2834   129  0.1938 0.2068
REMARK   3    18  2.0525 -  2.0138    1.00     2855   142  0.2052 0.2411
REMARK   3    19  2.0138 -  1.9779    1.00     2789   160  0.2046 0.2413
REMARK   3    20  1.9779 -  1.9443    1.00     2803   148  0.2168 0.2622
REMARK   3    21  1.9443 -  1.9130    1.00     2810   123  0.2225 0.2826
REMARK   3    22  1.9130 -  1.8836    0.99     2833   143  0.2292 0.2699
REMARK   3    23  1.8836 -  1.8559    0.98     2757   156  0.2469 0.2766
REMARK   3    24  1.8559 -  1.8297    0.95     2657   158  0.2507 0.2820
REMARK   3    25  1.8297 -  1.8050    0.86     2420   111  0.2681 0.2785
REMARK   3    26  1.8050 -  1.7816    0.56     1601    69  0.2779 0.3357
REMARK   3    27  1.7816 -  1.7593    0.29      817    34  0.2876 0.3471
REMARK   3    28  1.7593 -  1.7381    0.10      288     6  0.2617 0.5582
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : NULL
REMARK   3   SOLVENT RADIUS     : 1.11
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.180
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 21.960
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 26.30
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :  0.004           5815
REMARK   3   ANGLE     :  0.927           7837
REMARK   3   CHIRALITY :  0.035            799
REMARK   3   PLANARITY :  0.004           1019
REMARK   3   DIHEDRAL  : 13.147           2113
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 6NE9 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 18-DEC-18.
REMARK 100 THE DEPOSITION ID IS D_1000237972.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 28-OCT-17
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 6.5
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : APS
REMARK 200  BEAMLINE                       : 21-ID-D
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.979
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : PIXEL
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS EIGER X 9M
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000
REMARK 200  DATA SCALING SOFTWARE          : SCALEPACK
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 145030
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.738
REMARK 200  RESOLUTION RANGE LOW       (A) : 28.600
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 91.7
REMARK 200  DATA REDUNDANCY                : 1.900
REMARK 200  R MERGE                    (I) : 0.06100
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 15.3000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.74
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.80
REMARK 200  COMPLETENESS FOR SHELL     (%) : 28.6
REMARK 200  DATA REDUNDANCY IN SHELL       : 1.20
REMARK 200  R MERGE FOR SHELL          (I) : 0.22860
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: SAD
REMARK 200 SOFTWARE USED: AUTOSOL
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 51.53
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.54
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 10 MM AMMONIUM SULFATE, 80 MM SODIUM
REMARK 280  CACODYLATE PH 6.5, AND 21% PEG4000, VAPOR DIFFUSION, HANGING
REMARK 280  DROP, TEMPERATURE 293K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: C 2 2 21
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,-Y,Z+1/2
REMARK 290       3555   -X,Y,-Z+1/2
REMARK 290       4555   X,-Y,-Z
REMARK 290       5555   X+1/2,Y+1/2,Z
REMARK 290       6555   -X+1/2,-Y+1/2,Z+1/2
REMARK 290       7555   -X+1/2,Y+1/2,-Z+1/2
REMARK 290       8555   X+1/2,-Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       55.13000
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       55.13000
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   5  1.000000  0.000000  0.000000       58.35150
REMARK 290   SMTRY2   5  0.000000  1.000000  0.000000       63.27650
REMARK 290   SMTRY3   5  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   6 -1.000000  0.000000  0.000000       58.35150
REMARK 290   SMTRY2   6  0.000000 -1.000000  0.000000       63.27650
REMARK 290   SMTRY3   6  0.000000  0.000000  1.000000       55.13000
REMARK 290   SMTRY1   7 -1.000000  0.000000  0.000000       58.35150
REMARK 290   SMTRY2   7  0.000000  1.000000  0.000000       63.27650
REMARK 290   SMTRY3   7  0.000000  0.000000 -1.000000       55.13000
REMARK 290   SMTRY1   8  1.000000  0.000000  0.000000       58.35150
REMARK 290   SMTRY2   8  0.000000 -1.000000  0.000000       63.27650
REMARK 290   SMTRY3   8  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 3250 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 28350 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -18.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 375
REMARK 375 SPECIAL POSITION
REMARK 375 THE FOLLOWING ATOMS ARE FOUND TO BE WITHIN 0.15 ANGSTROMS
REMARK 375 OF A SYMMETRY RELATED ATOM AND ARE ASSUMED TO BE ON SPECIAL
REMARK 375 POSITIONS.
REMARK 375
REMARK 375 ATOM RES CSSEQI
REMARK 375      HOH A 722  LIES ON A SPECIAL POSITION.
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MSE A     1
REMARK 465     LYS A     2
REMARK 465     LYS A     3
REMARK 465     GLN A     4
REMARK 465     ILE A     5
REMARK 465     LEU A     6
REMARK 465     PHE A     7
REMARK 465     TRP A     8
REMARK 465     SER A     9
REMARK 465     MSE A    10
REMARK 465     MSE A    11
REMARK 465     SER A    12
REMARK 465     TRP A    13
REMARK 465     MSE A    14
REMARK 465     VAL A    15
REMARK 465     SER A    16
REMARK 465     VAL A    17
REMARK 465     GLY A    18
REMARK 465     LEU A    19
REMARK 465     PRO A    20
REMARK 465     SER A    21
REMARK 465     PHE A    22
REMARK 465     ALA A    23
REMARK 465     GLN A    24
REMARK 465     SER A   293
REMARK 465     ASN A   294
REMARK 465     TYR A   295
REMARK 465     PRO A   296
REMARK 465     SER A   297
REMARK 465     THR A   298
REMARK 465     GLU A   299
REMARK 465     PRO A   300
REMARK 465     MSE B     1
REMARK 465     LYS B     2
REMARK 465     LYS B     3
REMARK 465     GLN B     4
REMARK 465     ILE B     5
REMARK 465     LEU B     6
REMARK 465     PHE B     7
REMARK 465     TRP B     8
REMARK 465     SER B     9
REMARK 465     MSE B    10
REMARK 465     MSE B    11
REMARK 465     SER B    12
REMARK 465     TRP B    13
REMARK 465     MSE B    14
REMARK 465     VAL B    15
REMARK 465     SER B    16
REMARK 465     VAL B    17
REMARK 465     GLY B    18
REMARK 465     LEU B    19
REMARK 465     PRO B    20
REMARK 465     SER B    21
REMARK 465     PHE B    22
REMARK 465     ALA B    23
REMARK 465     GLN B    24
REMARK 465     LYS B   227
REMARK 465     SER B   228
REMARK 465     PRO B   229
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   O1   EDO A   410     O    HOH A   501              2.09
REMARK 500   O    HOH A   623     O    HOH A   689              2.14
REMARK 500   O    HOH A   681     O    HOH A   717              2.15
REMARK 500   O    HOH A   543     O    HOH A   735              2.16
REMARK 500   O    HOH A   614     O    HOH A   750              2.17
REMARK 500   OE2  GLU A    33     O    HOH A   502              2.17
REMARK 500   O    HOH B   581     O    HOH B   722              2.17
REMARK 500   O    HOH A   706     O    HOH A   759              2.17
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS
REMARK 500
REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC
REMARK 500 SYMMETRY ARE IN CLOSE CONTACT.  AN ATOM LOCATED WITHIN 0.15
REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A
REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375
REMARK 500 INSTEAD OF REMARK 500.  ATOMS WITH NON-BLANK ALTERNATE
REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS.
REMARK 500
REMARK 500 DISTANCE CUTOFF:
REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS
REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI  SSYMOP   DISTANCE
REMARK 500   O    HOH A   713     O    HOH A   713     3655     2.16
REMARK 500   O    HOH A   501     O    HOH B   507     6665     2.17
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    ALA A  56       72.92   -154.17
REMARK 500    ASP A 168      -75.74    -86.61
REMARK 500    ARG A 192      -79.35   -102.76
REMARK 500    SER A 266     -127.43     55.61
REMARK 500    ALA A 363     -148.79   -108.37
REMARK 500    ALA B  56       70.63   -150.62
REMARK 500    ARG B 192      -82.85    -93.08
REMARK 500    GLU B 242      -52.69   -121.39
REMARK 500    SER B 266     -123.00     49.91
REMARK 500    ALA B 363     -146.57   -108.79
REMARK 500
REMARK 500 REMARK: NULL
REMARK 525
REMARK 525 SOLVENT
REMARK 525
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 525 NUMBER; I=INSERTION CODE):
REMARK 525
REMARK 525  M RES CSSEQI
REMARK 525    HOH A 763        DISTANCE =  6.37 ANGSTROMS
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue PEG A 401
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue PEG A 402
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue PEG A 403
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO A 404
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO A 405
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO A 406
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO A 407
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO A 408
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO A 409
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO A 410
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue SO4 A 411
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue PEG B 401
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue PEG B 402
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue PEG B 403
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue PEG B 404
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue PEG B 405
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO B 406
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO B 407
REMARK 800
REMARK 800 SITE_IDENTIFIER: AE1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO B 408
REMARK 800
REMARK 800 SITE_IDENTIFIER: AE2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO B 409
REMARK 800
REMARK 800 SITE_IDENTIFIER: AE3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO B 410
DBREF  6NE9 A    1   382  PDB    6NE9     6NE9             1    382
DBREF  6NE9 B    1   382  PDB    6NE9     6NE9             1    382
SEQRES   1 A  382  MSE LYS LYS GLN ILE LEU PHE TRP SER MSE MSE SER TRP
SEQRES   2 A  382  MSE VAL SER VAL GLY LEU PRO SER PHE ALA GLN THR VAL
SEQRES   3 A  382  GLU ASP PHE LYS PRO SER GLU VAL ASN GLN PRO GLY LYS
SEQRES   4 A  382  LEU TYR PRO GLN VAL ASN SER GLU ARG LYS VAL ARG VAL
SEQRES   5 A  382  GLN ILE SER ALA PRO GLU ALA LYS VAL VAL GLN LEU ASP
SEQRES   6 A  382  LEU GLY GLY VAL LYS TYR ASP LEU THR LYS ASP GLU LYS
SEQRES   7 A  382  GLY VAL TRP THR GLY GLU SER ALA PRO GLN GLN GLU GLY
SEQRES   8 A  382  PHE HIS TYR TYR GLN LEU ASN VAL ASP GLY ALA ALA VAL
SEQRES   9 A  382  PRO ASP PRO GLY THR ILE TYR PHE TYR GLY ALA GLY ARG
SEQRES  10 A  382  TRP GLY SER GLY ILE GLU VAL PRO ALA HIS ASP ALA ASP
SEQRES  11 A  382  PHE TYR ALA LEU LYS ASP VAL PRO HIS GLY LEU LEU SER
SEQRES  12 A  382  GLU MSE ASN TYR TYR SER ASN LEU THR LYS ALA TRP ARG
SEQRES  13 A  382  ARG CYS PHE VAL TYR THR PRO ALA GLY TYR GLY ASP ASN
SEQRES  14 A  382  LYS ASP LYS ARG TYR PRO VAL LEU TYR LEU GLN HIS GLY
SEQRES  15 A  382  SER PHE GLU ASP GLU THR GLY TRP GLY ARG GLN GLY LYS
SEQRES  16 A  382  THR ASN LEU ILE LEU ASP ASN LEU ILE ALA ALA GLY LYS
SEQRES  17 A  382  ALA VAL PRO MSE LEU VAL VAL MSE ASP ASN GLY TYR ALA
SEQRES  18 A  382  THR LYS PRO GLY GLU LYS SER PRO PHE ALA ALA SER ILE
SEQRES  19 A  382  PHE GLU GLU VAL LEU MSE ASN GLU VAL ILE PRO MSE ILE
SEQRES  20 A  382  ASP ALA LYS PHE ARG THR LEU SER GLY ARG GLU ASP ARG
SEQRES  21 A  382  ALA ILE ALA GLY LEU SER MSE GLY ALA ASN GLN THR MSE
SEQRES  22 A  382  HIS ILE ALA MSE ASN ASN PRO GLY HIS PHE ALA TYR TYR
SEQRES  23 A  382  GLY GLY PHE SER GLY THR SER ASN TYR PRO SER THR GLU
SEQRES  24 A  382  PRO LEU ASP ALA THR THR PHE LEU ASN GLY LYS PHE LYS
SEQRES  25 A  382  ASP ALA LYS ALA VAL ASN VAL GLN PHE LYS VAL PHE PHE
SEQRES  26 A  382  LEU GLY LEU GLY THR ALA GLU PRO HIS PRO PHE PRO GLY
SEQRES  27 A  382  VAL VAL LYS ALA PHE ARG GLN MSE MSE ASP LYS GLN GLY
SEQRES  28 A  382  ILE LYS TYR VAL TYR TYR GLU SER PRO ASP THR ALA HIS
SEQRES  29 A  382  GLU TRP LEU THR TRP ARG ARG ALA LEU ASN GLU PHE ALA
SEQRES  30 A  382  PRO LEU LEU PHE LYS
SEQRES   1 B  382  MSE LYS LYS GLN ILE LEU PHE TRP SER MSE MSE SER TRP
SEQRES   2 B  382  MSE VAL SER VAL GLY LEU PRO SER PHE ALA GLN THR VAL
SEQRES   3 B  382  GLU ASP PHE LYS PRO SER GLU VAL ASN GLN PRO GLY LYS
SEQRES   4 B  382  LEU TYR PRO GLN VAL ASN SER GLU ARG LYS VAL ARG VAL
SEQRES   5 B  382  GLN ILE SER ALA PRO GLU ALA LYS VAL VAL GLN LEU ASP
SEQRES   6 B  382  LEU GLY GLY VAL LYS TYR ASP LEU THR LYS ASP GLU LYS
SEQRES   7 B  382  GLY VAL TRP THR GLY GLU SER ALA PRO GLN GLN GLU GLY
SEQRES   8 B  382  PHE HIS TYR TYR GLN LEU ASN VAL ASP GLY ALA ALA VAL
SEQRES   9 B  382  PRO ASP PRO GLY THR ILE TYR PHE TYR GLY ALA GLY ARG
SEQRES  10 B  382  TRP GLY SER GLY ILE GLU VAL PRO ALA HIS ASP ALA ASP
SEQRES  11 B  382  PHE TYR ALA LEU LYS ASP VAL PRO HIS GLY LEU LEU SER
SEQRES  12 B  382  GLU MSE ASN TYR TYR SER ASN LEU THR LYS ALA TRP ARG
SEQRES  13 B  382  ARG CYS PHE VAL TYR THR PRO ALA GLY TYR GLY ASP ASN
SEQRES  14 B  382  LYS ASP LYS ARG TYR PRO VAL LEU TYR LEU GLN HIS GLY
SEQRES  15 B  382  SER PHE GLU ASP GLU THR GLY TRP GLY ARG GLN GLY LYS
SEQRES  16 B  382  THR ASN LEU ILE LEU ASP ASN LEU ILE ALA ALA GLY LYS
SEQRES  17 B  382  ALA VAL PRO MSE LEU VAL VAL MSE ASP ASN GLY TYR ALA
SEQRES  18 B  382  THR LYS PRO GLY GLU LYS SER PRO PHE ALA ALA SER ILE
SEQRES  19 B  382  PHE GLU GLU VAL LEU MSE ASN GLU VAL ILE PRO MSE ILE
SEQRES  20 B  382  ASP ALA LYS PHE ARG THR LEU SER GLY ARG GLU ASP ARG
SEQRES  21 B  382  ALA ILE ALA GLY LEU SER MSE GLY ALA ASN GLN THR MSE
SEQRES  22 B  382  HIS ILE ALA MSE ASN ASN PRO GLY HIS PHE ALA TYR TYR
SEQRES  23 B  382  GLY GLY PHE SER GLY THR SER ASN TYR PRO SER THR GLU
SEQRES  24 B  382  PRO LEU ASP ALA THR THR PHE LEU ASN GLY LYS PHE LYS
SEQRES  25 B  382  ASP ALA LYS ALA VAL ASN VAL GLN PHE LYS VAL PHE PHE
SEQRES  26 B  382  LEU GLY LEU GLY THR ALA GLU PRO HIS PRO PHE PRO GLY
SEQRES  27 B  382  VAL VAL LYS ALA PHE ARG GLN MSE MSE ASP LYS GLN GLY
SEQRES  28 B  382  ILE LYS TYR VAL TYR TYR GLU SER PRO ASP THR ALA HIS
SEQRES  29 B  382  GLU TRP LEU THR TRP ARG ARG ALA LEU ASN GLU PHE ALA
SEQRES  30 B  382  PRO LEU LEU PHE LYS
MODRES 6NE9 MSE A  212  MET  MODIFIED RESIDUE
MODRES 6NE9 MSE A  216  MET  MODIFIED RESIDUE
MODRES 6NE9 MSE A  246  MET  MODIFIED RESIDUE
MODRES 6NE9 MSE A  267  MET  MODIFIED RESIDUE
MODRES 6NE9 MSE B  212  MET  MODIFIED RESIDUE
MODRES 6NE9 MSE B  216  MET  MODIFIED RESIDUE
MODRES 6NE9 MSE B  246  MET  MODIFIED RESIDUE
MODRES 6NE9 MSE B  267  MET  MODIFIED RESIDUE
HET    MSE  A 145      17
HET    MSE  A 212      17
HET    MSE  A 216      17
HET    MSE  A 240      17
HET    MSE  A 246      17
HET    MSE  A 267      10
HET    MSE  A 273      17
HET    MSE  A 277       8
HET    MSE  A 346      10
HET    MSE  A 347      10
HET    MSE  B 145      17
HET    MSE  B 212      17
HET    MSE  B 216      17
HET    MSE  B 240      17
HET    MSE  B 246      17
HET    MSE  B 267      17
HET    MSE  B 273      17
HET    MSE  B 277      17
HET    MSE  B 346      17
HET    MSE  B 347      10
HET    PEG  A 401      17
HET    PEG  A 402      17
HET    PEG  A 403      17
HET    EDO  A 404      10
HET    EDO  A 405      10
HET    EDO  A 406      10
HET    EDO  A 407      10
HET    EDO  A 408      10
HET    EDO  A 409      10
HET    EDO  A 410      10
HET    SO4  A 411       5
HET    PEG  B 401      17
HET    PEG  B 402      17
HET    PEG  B 403      17
HET    PEG  B 404      17
HET    PEG  B 405      17
HET    EDO  B 406      10
HET    EDO  B 407      10
HET    EDO  B 408      10
HET    EDO  B 409      10
HET    EDO  B 410      10
HET     CL  B 411       1
HETNAM     MSE SELENOMETHIONINE
HETNAM     PEG DI(HYDROXYETHYL)ETHER
HETNAM     EDO 1,2-ETHANEDIOL
HETNAM     SO4 SULFATE ION
HETNAM      CL CHLORIDE ION
HETSYN     EDO ETHYLENE GLYCOL
FORMUL   1  MSE    20(C5 H11 N O2 SE)
FORMUL   3  PEG    8(C4 H10 O3)
FORMUL   6  EDO    12(C2 H6 O2)
FORMUL  13  SO4    O4 S 2-
FORMUL  24   CL    CL 1-
FORMUL  25  HOH   *487(H2 O)
HELIX    1 AA1 ASP A  128  ALA A  133  5                                   6
HELIX    2 AA2 PRO A  163  ASP A  168  5                                   6
HELIX    3 AA3 LYS A  195  ALA A  206  1                                  12
HELIX    4 AA4 ILE A  234  GLU A  242  1                                   9
HELIX    5 AA5 GLU A  242  PHE A  251  1                                  10
HELIX    6 AA6 GLY A  256  GLU A  258  5                                   3
HELIX    7 AA7 SER A  266  ASN A  279  1                                  14
HELIX    8 AA8 ASP A  313  PHE A  321  1                                   9
HELIX    9 AA9 PRO A  335  GLY A  351  1                                  17
HELIX   10 AB1 GLU A  365  ALA A  377  1                                  13
HELIX   11 AB2 PRO A  378  LEU A  380  5                                   3
HELIX   12 AB3 ASP B  128  ALA B  133  5                                   6
HELIX   13 AB4 LYS B  195  ALA B  206  1                                  12
HELIX   14 AB5 ILE B  234  GLU B  242  1                                   9
HELIX   15 AB6 GLU B  242  PHE B  251  1                                  10
HELIX   16 AB7 GLY B  256  GLU B  258  5                                   3
HELIX   17 AB8 SER B  266  ASN B  279  1                                  14
HELIX   18 AB9 ASP B  313  PHE B  321  1                                   9
HELIX   19 AC1 PRO B  335  GLY B  351  1                                  17
HELIX   20 AC2 GLU B  365  ALA B  377  1                                  13
HELIX   21 AC3 PRO B  378  LEU B  380  5                                   3
SHEET    1 AA1 5 LYS A  30  PRO A  31  0
SHEET    2 AA1 5 GLN A  43  VAL A  44 -1  O  VAL A  44   N  LYS A  30
SHEET    3 AA1 5 VAL A  50  SER A  55 -1  O  ARG A  51   N  GLN A  43
SHEET    4 AA1 5 VAL A  80  GLU A  84 -1  O  TRP A  81   N  ILE A  54
SHEET    5 AA1 5 THR A  74  LYS A  75 -1  N  THR A  74   O  THR A  82
SHEET    1 AA2 4 VAL A  69  ASP A  72  0
SHEET    2 AA2 4 VAL A  62  LEU A  66 -1  N  LEU A  64   O  TYR A  71
SHEET    3 AA2 4 GLY A  91  VAL A  99 -1  O  ASN A  98   N  GLN A  63
SHEET    4 AA2 4 ALA A 102  VAL A 104 -1  O  VAL A 104   N  LEU A  97
SHEET    1 AA3 5 VAL A  69  ASP A  72  0
SHEET    2 AA3 5 VAL A  62  LEU A  66 -1  N  LEU A  64   O  TYR A  71
SHEET    3 AA3 5 GLY A  91  VAL A  99 -1  O  ASN A  98   N  GLN A  63
SHEET    4 AA3 5 ARG A 117  VAL A 124 -1  O  VAL A 124   N  GLY A  91
SHEET    5 AA3 5 TYR A 111  GLY A 114 -1  N  PHE A 112   O  GLY A 119
SHEET    1 AA416 VAL A 355  SER A 359  0
SHEET    2 AA416 VAL A 323  GLY A 329  1  N  PHE A 324   O  VAL A 355
SHEET    3 AA416 TYR A 285  PHE A 289  1  N  GLY A 288   O  PHE A 325
SHEET    4 AA416 ARG A 260  LEU A 265  1  N  GLY A 264   O  PHE A 289
SHEET    5 AA416 VAL A 176  GLN A 180  1  N  TYR A 178   O  ALA A 261
SHEET    6 AA416 LEU A 213  MSE A 216  1  O  VAL A 215   N  LEU A 177
SHEET    7 AA416 ALA A 154  TYR A 161 -1  N  PHE A 159   O  MSE A 216
SHEET    8 AA416 LEU A 142  SER A 149 -1  N  TYR A 147   O  ARG A 156
SHEET    9 AA416 LEU B 141  SER B 149 -1  O  GLU B 144   N  LEU A 142
SHEET   10 AA416 ALA B 154  THR B 162 -1  O  ARG B 156   N  TYR B 147
SHEET   11 AA416 LEU B 213  MSE B 216 -1  O  MSE B 216   N  PHE B 159
SHEET   12 AA416 VAL B 176  GLN B 180  1  N  LEU B 177   O  VAL B 215
SHEET   13 AA416 ARG B 260  LEU B 265  1  O  ALA B 261   N  VAL B 176
SHEET   14 AA416 TYR B 285  PHE B 289  1  O  PHE B 289   N  GLY B 264
SHEET   15 AA416 VAL B 323  GLY B 329  1  O  PHE B 325   N  TYR B 286
SHEET   16 AA416 VAL B 355  SER B 359  1  O  VAL B 355   N  PHE B 324
SHEET    1 AA5 5 LYS B  30  PRO B  31  0
SHEET    2 AA5 5 GLN B  43  VAL B  44 -1  O  VAL B  44   N  LYS B  30
SHEET    3 AA5 5 VAL B  50  SER B  55 -1  O  ARG B  51   N  GLN B  43
SHEET    4 AA5 5 VAL B  80  GLU B  84 -1  O  TRP B  81   N  ILE B  54
SHEET    5 AA5 5 THR B  74  LYS B  75 -1  N  THR B  74   O  THR B  82
SHEET    1 AA6 4 VAL B  69  ASP B  72  0
SHEET    2 AA6 4 VAL B  62  LEU B  66 -1  N  LEU B  64   O  TYR B  71
SHEET    3 AA6 4 GLY B  91  VAL B  99 -1  O  GLN B  96   N  ASP B  65
SHEET    4 AA6 4 ALA B 102  VAL B 104 -1  O  VAL B 104   N  LEU B  97
SHEET    1 AA7 4 VAL B  69  ASP B  72  0
SHEET    2 AA7 4 VAL B  62  LEU B  66 -1  N  LEU B  64   O  TYR B  71
SHEET    3 AA7 4 GLY B  91  VAL B  99 -1  O  GLN B  96   N  ASP B  65
SHEET    4 AA7 4 GLY B 121  VAL B 124 -1  O  VAL B 124   N  GLY B  91
SHEET    1 AA8 2 PHE B 112  GLY B 114  0
SHEET    2 AA8 2 ARG B 117  GLY B 119 -1  O  GLY B 119   N  PHE B 112
LINK         C   GLU A 144                 N   MSE A 145     1555   1555  1.33
LINK         C   MSE A 145                 N   ASN A 146     1555   1555  1.33
LINK         C   PRO A 211                 N   MSE A 212     1555   1555  1.33
LINK         C   MSE A 212                 N   LEU A 213     1555   1555  1.33
LINK         C   VAL A 215                 N   MSE A 216     1555   1555  1.33
LINK         C   MSE A 216                 N   ASP A 217     1555   1555  1.33
LINK         C   LEU A 239                 N   MSE A 240     1555   1555  1.33
LINK         C   MSE A 240                 N   ASN A 241     1555   1555  1.33
LINK         C   PRO A 245                 N   MSE A 246     1555   1555  1.33
LINK         C   MSE A 246                 N   ILE A 247     1555   1555  1.33
LINK         C   SER A 266                 N   MSE A 267     1555   1555  1.34
LINK         C   MSE A 267                 N   GLY A 268     1555   1555  1.33
LINK         C   THR A 272                 N   MSE A 273     1555   1555  1.33
LINK         C   MSE A 273                 N   HIS A 274     1555   1555  1.33
LINK         C   ALA A 276                 N   MSE A 277     1555   1555  1.33
LINK         C   MSE A 277                 N   ASN A 278     1555   1555  1.33
LINK         C   GLN A 345                 N   MSE A 346     1555   1555  1.33
LINK         C   MSE A 346                 N   MSE A 347     1555   1555  1.33
LINK         C   MSE A 347                 N   ASP A 348     1555   1555  1.33
LINK         C   GLU B 144                 N   MSE B 145     1555   1555  1.33
LINK         C   MSE B 145                 N   ASN B 146     1555   1555  1.33
LINK         C   PRO B 211                 N   MSE B 212     1555   1555  1.33
LINK         C   MSE B 212                 N   LEU B 213     1555   1555  1.33
LINK         C   VAL B 215                 N   MSE B 216     1555   1555  1.33
LINK         C   MSE B 216                 N   ASP B 217     1555   1555  1.33
LINK         C   LEU B 239                 N   MSE B 240     1555   1555  1.33
LINK         C   MSE B 240                 N   ASN B 241     1555   1555  1.33
LINK         C   PRO B 245                 N   MSE B 246     1555   1555  1.33
LINK         C   MSE B 246                 N   ILE B 247     1555   1555  1.33
LINK         C   SER B 266                 N   MSE B 267     1555   1555  1.34
LINK         C   MSE B 267                 N   GLY B 268     1555   1555  1.33
LINK         C   THR B 272                 N   MSE B 273     1555   1555  1.33
LINK         C   MSE B 273                 N   HIS B 274     1555   1555  1.33
LINK         C   ALA B 276                 N   MSE B 277     1555   1555  1.33
LINK         C   MSE B 277                 N   ASN B 278     1555   1555  1.33
LINK         C   GLN B 345                 N   MSE B 346     1555   1555  1.33
LINK         C   MSE B 346                 N   MSE B 347     1555   1555  1.33
LINK         C   MSE B 347                 N   ASP B 348     1555   1555  1.33
CISPEP   1 TYR A   41    PRO A   42          0         8.76
CISPEP   2 HIS A  334    PRO A  335          0         5.48
CISPEP   3 TYR B   41    PRO B   42          0         8.49
CISPEP   4 TYR B  295    PRO B  296          0         3.95
CISPEP   5 HIS B  334    PRO B  335          0         3.50
SITE     1 AC1  3 TRP A 118  ARG A 157  ARG B 192
SITE     1 AC2  9 GLY A 191  ARG A 192  LYS A 195  ASN A 197
SITE     2 AC2  9 EDO A 405  HOH A 529  HOH A 543  GLU B 144
SITE     3 AC2  9 EDO B 407
SITE     1 AC3  6 ARG A 156  ARG A 157  ASP A 217  ASN A 218
SITE     2 AC3  6 TYR A 220  HOH A 565
SITE     1 AC4  5 SER A 233  PHE A 235  GLU A 236  GLN A 271
SITE     2 AC4  5 HOH A 556
SITE     1 AC5  9 GLU A  33  PHE A  92  PHE A 112  GLU A 123
SITE     2 AC5  9 ARG A 192  LYS A 195  PEG A 402  HOH A 502
SITE     3 AC5  9 HOH A 543
SITE     1 AC6  6 ASP A 128  TYR A 357  ASN A 374  GLU A 375
SITE     2 AC6  6 HOH A 508  HOH A 645
SITE     1 AC7  5 PHE A 131  LYS A 135  ALA A 206  HOH A 532
SITE     2 AC7  5 HOH A 648
SITE     1 AC8  4 GLU A  27  ASP A  28  PHE A  29  HOH A 523
SITE     1 AC9  4 GLU A 144  ASN A 146  ASN B 197  PEG B 403
SITE     1 AD1  4 ARG A  48  GLN A  88  HOH A 501  GLU B 299
SITE     1 AD2  5 HIS A 334  PRO A 335  PRO A 337  GLY A 338
SITE     2 AD2  5 HOH A 630
SITE     1 AD3  6 SER B 233  ILE B 234  PHE B 235  GLU B 236
SITE     2 AD3  6 GLU B 237  GLN B 271
SITE     1 AD4  4 HIS B 334  PRO B 335  PRO B 337  GLY B 338
SITE     1 AD5  8 GLU A 144  EDO A 409  LEU B 142  GLY B 191
SITE     2 AD5  8 ARG B 192  LYS B 195  ASN B 197  PEG B 404
SITE     1 AD6  8 GLU B  33  VAL B  34  PHE B 112  GLU B 123
SITE     2 AD6  8 ARG B 192  LYS B 195  ARG B 370  PEG B 403
SITE     1 AD7  4 TYR B 166  LYS B 250  ARG B 252  HOH B 519
SITE     1 AD8  4 PRO A  37  GLU B 185  ASP B 186  ASN B 218
SITE     1 AD9  5 ASN A 197  PEG A 402  GLU B 144  ASN B 146
SITE     2 AD9  5 ARG B 157
SITE     1 AE1  5 ASP B 128  TYR B 357  ASN B 374  GLU B 375
SITE     2 AE1  5 HOH B 657
SITE     1 AE2  4 LEU B 203  HOH B 503  HOH B 511  HOH B 621
SITE     1 AE3  7 SER B 266  MSE B 267  ASN B 270  SER B 290
SITE     2 AE3  7 TYR B 295  PHE B 336  HOH B 501
CRYST1  116.703  126.553  110.260  90.00  90.00  90.00 C 2 2 21     16
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.008569  0.000000  0.000000        0.00000
SCALE2      0.000000  0.007902  0.000000        0.00000
SCALE3      0.000000  0.000000  0.009069        0.00000
TER    5404      LYS A 382
TER   10903      LYS B 382
MASTER      472    0   42   21   45    0   36    6 6159    2  600   60
END