longtext: 6scd-pdb

content
HEADER    HYDROLASE                               24-JUL-19   6SCD
TITLE     POLYESTER HYDROLASE PE-H Y250S MUTANT OF PSEUDOMONAS AESTUSNIGRI
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: POLYESTER HYDROLASE;
COMPND   3 CHAIN: A, B;
COMPND   4 ENGINEERED: YES;
COMPND   5 MUTATION: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: PSEUDOMONAS AESTUSNIGRI;
SOURCE   3 ORGANISM_TAXID: 857252;
SOURCE   4 GENE: B7O88_11480;
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 562
KEYWDS    POLYESTER DEGRADATION, PET HYDROLASE, MARINE BACTERIA, PSEUDOMONAS
KEYWDS   2 AESTUSNIGRI, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    A.BOLLINGER,S.THIES,S.KOBUS,A.HOEPPNER,S.H.J.SMITS,K.-E.JAEGER
REVDAT   1   26-FEB-20 6SCD    0
JRNL        AUTH   A.BOLLINGER,S.THIES,S.KOBUS,A.HOEPPNER,S.H.J.SMITS,
JRNL        AUTH 2 C.COSCOLIN,M.FERRER,K.-E.JAEGER
JRNL        TITL   A NOVEL POLYESTER HYDROLASE FROM THE MARINE BACTERIUM
JRNL        TITL 2 PSEUDOMONAS AESTUSNIGRI - STRUCTURAL AND FUNCTIONAL INSIGHTS
JRNL        REF    FRONT MICROBIOL                            2020
JRNL        REFN                   ESSN 1664-302X
JRNL        DOI    10.3389/FMICB.2020.00114
REMARK   2
REMARK   2 RESOLUTION.    1.35 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.8.0131
REMARK   3   AUTHORS     : MURSHUDOV,SKUBAK,LEBEDEV,PANNU,STEINER,
REMARK   3               : NICHOLLS,WINN,LONG,VAGIN
REMARK   3
REMARK   3    REFINEMENT TARGET : NULL
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.35
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 76.34
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0.000
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.1
REMARK   3   NUMBER OF REFLECTIONS             : 116011
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.115
REMARK   3   R VALUE            (WORKING SET) : 0.113
REMARK   3   FREE R VALUE                     : 0.152
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.900
REMARK   3   FREE R VALUE TEST SET COUNT      : 6011
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 1.35
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 1.39
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 8523
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 99.12
REMARK   3   BIN R VALUE           (WORKING SET) : 0.2000
REMARK   3   BIN FREE R VALUE SET COUNT          : 417
REMARK   3   BIN FREE R VALUE                    : 0.2350
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 3995
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 49
REMARK   3   SOLVENT ATOMS            : 493
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 21.68
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : -0.13000
REMARK   3    B22 (A**2) : 0.38000
REMARK   3    B33 (A**2) : -0.25000
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : 0.00000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): 0.038
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.042
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.027
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 1.536
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.985
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.976
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A):  4203 ; 0.026 ; 0.019
REMARK   3   BOND LENGTHS OTHERS               (A):  3770 ; 0.002 ; 0.020
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES):  5736 ; 2.430 ; 1.951
REMARK   3   BOND ANGLES OTHERS          (DEGREES):  8707 ; 1.336 ; 3.000
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):   556 ; 6.725 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   173 ;29.813 ;23.353
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):   620 ;11.220 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):    26 ;15.410 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):   617 ; 0.149 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A):  4866 ; 0.015 ; 0.021
REMARK   3   GENERAL PLANES OTHERS             (A):   988 ; 0.006 ; 0.020
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN ANGLE OTHER ATOMS   (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN ANGLE OTHER ATOMS   (A**2):  NULL ;  NULL ;  NULL
REMARK   3   LONG RANGE B REFINED ATOMS     (A**2):  NULL ;  NULL ;  NULL
REMARK   3   LONG RANGE B OTHER ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  7972 ; 5.799 ; 3.000
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):   155 ;39.352 ; 5.000
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  8206 ;15.367 ; 5.000
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : NULL
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.20
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE RIDING
REMARK   3  POSITIONS U VALUES : REFINED INDIVIDUALLY
REMARK   4
REMARK   4 6SCD COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 24-JUL-19.
REMARK 100 THE DEPOSITION ID IS D_1292103437.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 16-APR-19
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : NULL
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : PETRA III, EMBL C/O DESY
REMARK 200  BEAMLINE                       : P13 (MX1)
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.950500
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : PIXEL
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS PILATUS 6M
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200  DATA SCALING SOFTWARE          : XDS
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 122029
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.350
REMARK 200  RESOLUTION RANGE LOW       (A) : 77.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.1
REMARK 200  DATA REDUNDANCY                : 4.050
REMARK 200  R MERGE                    (I) : NULL
REMARK 200  R SYM                      (I) : 0.04300
REMARK 200   FOR THE DATA SET  : 14.9800
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.35
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.42
REMARK 200  COMPLETENESS FOR SHELL     (%) : NULL
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL
REMARK 200  R MERGE FOR SHELL          (I) : NULL
REMARK 200  R SYM FOR SHELL            (I) : 0.43900
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: 6SBN
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 50.00
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.46
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.2 M AMMONIUM SULPHATE, 0.1 M SODIUM
REMARK 280  CITRATE PH 3.5, 28 % (V/V) PEG 400, VAPOR DIFFUSION, SITTING
REMARK 280  DROP, TEMPERATURE 285K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: I 21 21 21
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X+1/2,-Y,Z+1/2
REMARK 290       3555   -X,Y+1/2,-Z+1/2
REMARK 290       4555   X+1/2,-Y+1/2,-Z
REMARK 290       5555   X+1/2,Y+1/2,Z+1/2
REMARK 290       6555   -X,-Y+1/2,Z
REMARK 290       7555   -X+1/2,Y,-Z
REMARK 290       8555   X,-Y,-Z+1/2
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       47.26300
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       60.61650
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       49.13400
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       60.61650
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       47.26300
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       49.13400
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   5  1.000000  0.000000  0.000000       47.26300
REMARK 290   SMTRY2   5  0.000000  1.000000  0.000000       49.13400
REMARK 290   SMTRY3   5  0.000000  0.000000  1.000000       60.61650
REMARK 290   SMTRY1   6 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   6  0.000000 -1.000000  0.000000       49.13400
REMARK 290   SMTRY3   6  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   7 -1.000000  0.000000  0.000000       47.26300
REMARK 290   SMTRY2   7  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   7  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   8  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   8  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   8  0.000000  0.000000 -1.000000       60.61650
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A     1
REMARK 465     PRO A     2
REMARK 465     PHE A     3
REMARK 465     ASN A     4
REMARK 465     LYS A     5
REMARK 465     LYS A     6
REMARK 465     SER A     7
REMARK 465     VAL A     8
REMARK 465     LEU A     9
REMARK 465     ALA A    10
REMARK 465     LEU A    11
REMARK 465     CYS A    12
REMARK 465     GLY A    13
REMARK 465     ALA A    14
REMARK 465     GLY A    15
REMARK 465     ALA A    16
REMARK 465     LEU A    17
REMARK 465     LEU A    18
REMARK 465     PHE A    19
REMARK 465     SER A    20
REMARK 465     MET A    21
REMARK 465     SER A    22
REMARK 465     ALA A    23
REMARK 465     LEU A    24
REMARK 465     ALA A    25
REMARK 465     ASN A    26
REMARK 465     ASN A    27
REMARK 465     PRO A    28
REMARK 465     ALA A    29
REMARK 465     PRO A    30
REMARK 465     THR A    31
REMARK 465     ASP A    32
REMARK 465     PRO A    33
REMARK 465     GLY A    34
REMARK 465     ASP A    35
REMARK 465     SER A    36
REMARK 465     GLY A    37
REMARK 465     GLY A    38
REMARK 465     GLY A    39
REMARK 465     GLU A   306
REMARK 465     HIS A   307
REMARK 465     HIS A   308
REMARK 465     HIS A   309
REMARK 465     HIS A   310
REMARK 465     HIS A   311
REMARK 465     HIS A   312
REMARK 465     MET B     1
REMARK 465     PRO B     2
REMARK 465     PHE B     3
REMARK 465     ASN B     4
REMARK 465     LYS B     5
REMARK 465     LYS B     6
REMARK 465     SER B     7
REMARK 465     VAL B     8
REMARK 465     LEU B     9
REMARK 465     ALA B    10
REMARK 465     LEU B    11
REMARK 465     CYS B    12
REMARK 465     GLY B    13
REMARK 465     ALA B    14
REMARK 465     GLY B    15
REMARK 465     ALA B    16
REMARK 465     LEU B    17
REMARK 465     LEU B    18
REMARK 465     PHE B    19
REMARK 465     SER B    20
REMARK 465     MET B    21
REMARK 465     SER B    22
REMARK 465     ALA B    23
REMARK 465     LEU B    24
REMARK 465     ALA B    25
REMARK 465     ASN B    26
REMARK 465     ASN B    27
REMARK 465     PRO B    28
REMARK 465     ALA B    29
REMARK 465     PRO B    30
REMARK 465     THR B    31
REMARK 465     ASP B    32
REMARK 465     PRO B    33
REMARK 465     GLY B    34
REMARK 465     ASP B    35
REMARK 465     SER B    36
REMARK 465     GLY B    37
REMARK 465     GLY B    38
REMARK 465     GLY B    39
REMARK 465     GLU B   306
REMARK 465     HIS B   307
REMARK 465     HIS B   308
REMARK 465     HIS B   309
REMARK 465     HIS B   310
REMARK 465     HIS B   311
REMARK 465     HIS B   312
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     ARG A  63    NE   CZ   NH1  NH2
REMARK 470     LEU A 305    CG   CD1  CD2
REMARK 470     SER B  40    OG
REMARK 470     ARG B  63    CD   NE   CZ   NH1  NH2
REMARK 470     ARG B  66    CG   CD   NE   CZ   NH1  NH2
REMARK 470     PHE B  98    CG   CD1  CD2  CE1  CE2  CZ
REMARK 470     ARG B 157    CG   CD   NE   CZ   NH1  NH2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   O    HOH B   525     O    HOH B   677              2.10
REMARK 500   OE1  GLN B   294     O    HOH B   501              2.11
REMARK 500   O    HOH A   511     O    HOH A   690              2.12
REMARK 500   O    HOH B   667     O    HOH B   703              2.13
REMARK 500   O    HOH A   676     O    HOH A   696              2.14
REMARK 500   OE1  GLU A   243     O    HOH A   501              2.15
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION
REMARK 500    GLU A 102   CB    GLU A 102   CG     -0.133
REMARK 500    GLU A 102   CD    GLU A 102   OE2    -0.109
REMARK 500    SER A 152   CB    SER A 152   OG     -0.087
REMARK 500    GLU A 183   CD    GLU A 183   OE1     0.094
REMARK 500    SER A 256   CB    SER A 256   OG     -0.212
REMARK 500    GLU A 276   CD    GLU A 276   OE1    -0.080
REMARK 500    SER B  40   CA    SER B  40   CB      0.155
REMARK 500    GLY B  97   N     GLY B  97   CA      0.093
REMARK 500    GLU B 102   CB    GLU B 102   CG     -0.141
REMARK 500    GLU B 102   CD    GLU B 102   OE1    -0.072
REMARK 500    GLU B 183   CD    GLU B 183   OE2    -0.070
REMARK 500    GLU B 215   CD    GLU B 215   OE2     0.080
REMARK 500    SER B 232   CA    SER B 232   CB      0.092
REMARK 500    ASN B 288   N     ASN B 288   CA      0.133
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    ARG A  66   NE  -  CZ  -  NH1 ANGL. DEV. =   3.2 DEGREES
REMARK 500    ARG A  66   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.2 DEGREES
REMARK 500    GLU A 102   OE1 -  CD  -  OE2 ANGL. DEV. =  -7.6 DEGREES
REMARK 500    GLU A 102   CG  -  CD  -  OE1 ANGL. DEV. =  12.5 DEGREES
REMARK 500    ASP A 106   CB  -  CG  -  OD1 ANGL. DEV. =   6.0 DEGREES
REMARK 500    ASP A 106   CB  -  CG  -  OD2 ANGL. DEV. =  -5.8 DEGREES
REMARK 500    PHE A 128   CB  -  CG  -  CD2 ANGL. DEV. =   4.6 DEGREES
REMARK 500    ARG A 136   NE  -  CZ  -  NH1 ANGL. DEV. =  -5.1 DEGREES
REMARK 500    GLU A 243   OE1 -  CD  -  OE2 ANGL. DEV. =   7.3 DEGREES
REMARK 500    ASP A 292   CB  -  CG  -  OD1 ANGL. DEV. =   6.9 DEGREES
REMARK 500    ARG A 299   NE  -  CZ  -  NH1 ANGL. DEV. =   4.0 DEGREES
REMARK 500    ARG B  44   NE  -  CZ  -  NH2 ANGL. DEV. =   3.2 DEGREES
REMARK 500    LEU B 112   CB  -  CG  -  CD1 ANGL. DEV. =  13.6 DEGREES
REMARK 500    PHE B 117   CB  -  CG  -  CD1 ANGL. DEV. =   4.6 DEGREES
REMARK 500    PHE B 117   CZ  -  CE2 -  CD2 ANGL. DEV. =   8.3 DEGREES
REMARK 500    PHE B 128   CB  -  CG  -  CD2 ANGL. DEV. =  -4.4 DEGREES
REMARK 500    ASP B 143   CB  -  CG  -  OD2 ANGL. DEV. =  -6.9 DEGREES
REMARK 500    TYR B 200   CZ  -  CE2 -  CD2 ANGL. DEV. =  -6.3 DEGREES
REMARK 500    ASP B 238   CB  -  CG  -  OD2 ANGL. DEV. =  -7.9 DEGREES
REMARK 500    ARG B 264   NE  -  CZ  -  NH2 ANGL. DEV. =  -4.5 DEGREES
REMARK 500    ASP B 275   CB  -  CG  -  OD1 ANGL. DEV. =   5.5 DEGREES
REMARK 500    ASP B 277   CB  -  CG  -  OD2 ANGL. DEV. =  -6.0 DEGREES
REMARK 500    TYR B 280   CD1 -  CE1 -  CZ  ANGL. DEV. =   6.5 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    SER A 171     -118.88     65.52
REMARK 500    HIS A 225      -87.27   -134.55
REMARK 500    SER A 256     -127.17   -125.81
REMARK 500    VAL B  99       22.04     45.24
REMARK 500    SER B 171     -122.95     67.43
REMARK 500    ALA B 220       70.69   -118.86
REMARK 500    HIS B 225      -89.51   -129.55
REMARK 500    SER B 256     -134.75   -126.76
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: PLANAR GROUPS
REMARK 500
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS
REMARK 500 AN RMSD GREATER THAN THIS VALUE
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500  M RES CSSEQI        RMS     TYPE
REMARK 500    ASP A 106         0.09    SIDE CHAIN
REMARK 500    ARG A 134         0.11    SIDE CHAIN
REMARK 500    ARG B 134         0.09    SIDE CHAIN
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: MAIN CHAIN PLANARITY
REMARK 500
REMARK 500 THE FOLLOWING RESIDUES HAVE A PSEUDO PLANARITY
REMARK 500 TORSION ANGLE, C(I) - CA(I) - N(I+1) - O(I), GREATER
REMARK 500 10.0 DEGREES. (M=MODEL NUMBER; RES=RESIDUE NAME;
REMARK 500 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 500 I=INSERTION CODE).
REMARK 500
REMARK 500  M RES CSSEQI        ANGLE
REMARK 500    GLY B  58        -10.02
REMARK 500
REMARK 500 REMARK: NULL
REMARK 525
REMARK 525 SOLVENT
REMARK 525
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 525 NUMBER; I=INSERTION CODE):
REMARK 525
REMARK 525  M RES CSSEQI
REMARK 525    HOH A 780        DISTANCE =  5.86 ANGSTROMS
REMARK 525    HOH A 781        DISTANCE =  6.03 ANGSTROMS
REMARK 525    HOH A 782        DISTANCE =  6.19 ANGSTROMS
REMARK 525    HOH A 783        DISTANCE =  6.28 ANGSTROMS
REMARK 525    HOH A 784        DISTANCE =  6.78 ANGSTROMS
REMARK 525    HOH A 785        DISTANCE =  6.95 ANGSTROMS
REMARK 525    HOH A 786        DISTANCE =  7.33 ANGSTROMS
REMARK 525    HOH A 787        DISTANCE =  7.90 ANGSTROMS
REMARK 525    HOH A 788        DISTANCE =  8.09 ANGSTROMS
REMARK 525    HOH B 705        DISTANCE =  6.42 ANGSTROMS
REMARK 620
REMARK 620 METAL COORDINATION
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              NA A 404  NA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 THR A 290   O
REMARK 620 2 ASP A 292   O    92.7
REMARK 620 3 ILE A 295   O    90.0  84.4
REMARK 620 4 HOH A 607   O    94.1  87.2 170.8
REMARK 620 5 HOH A 693   O   173.1  93.7  87.9  88.9
REMARK 620 6 HOH A 714   O    85.0 173.2 101.9  86.6  89.0
REMARK 620 N                    1     2     3     4     5
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              NA B 402  NA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 SER B 171   OG
REMARK 620 2 HOH B 606   O    63.3
REMARK 620 N                    1
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              NA B 403  NA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 PRO B 194   O
REMARK 620 2 ALA B 220   O   109.9
REMARK 620 3 HOH B 607   O   134.3  77.2
REMARK 620 N                    1     2
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue SO4 A 401
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue PO4 A 402
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue PO4 A 403
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue NA A 404
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CL A 405
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CL A 406
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue PEG A 407
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue GOL A 408
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue GOL A 409
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ACT A 410
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue PO4 B 401
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue NA B 402
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue NA B 403
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CL B 404
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 6SBN   RELATED DB: PDB
REMARK 900 WILDTYPE
DBREF1 6SCD A    1   304  UNP                  A0A1H6AD45_9PSED
DBREF2 6SCD A     A0A1H6AD45                          1         304
DBREF1 6SCD B    1   304  UNP                  A0A1H6AD45_9PSED
DBREF2 6SCD B     A0A1H6AD45                          1         304
SEQADV 6SCD SER A  250  UNP  A0A1H6AD4 TYR   250 ENGINEERED MUTATION
SEQADV 6SCD LEU A  305  UNP  A0A1H6AD4           EXPRESSION TAG
SEQADV 6SCD GLU A  306  UNP  A0A1H6AD4           EXPRESSION TAG
SEQADV 6SCD HIS A  307  UNP  A0A1H6AD4           EXPRESSION TAG
SEQADV 6SCD HIS A  308  UNP  A0A1H6AD4           EXPRESSION TAG
SEQADV 6SCD HIS A  309  UNP  A0A1H6AD4           EXPRESSION TAG
SEQADV 6SCD HIS A  310  UNP  A0A1H6AD4           EXPRESSION TAG
SEQADV 6SCD HIS A  311  UNP  A0A1H6AD4           EXPRESSION TAG
SEQADV 6SCD HIS A  312  UNP  A0A1H6AD4           EXPRESSION TAG
SEQADV 6SCD SER B  250  UNP  A0A1H6AD4 TYR   250 ENGINEERED MUTATION
SEQADV 6SCD LEU B  305  UNP  A0A1H6AD4           EXPRESSION TAG
SEQADV 6SCD GLU B  306  UNP  A0A1H6AD4           EXPRESSION TAG
SEQADV 6SCD HIS B  307  UNP  A0A1H6AD4           EXPRESSION TAG
SEQADV 6SCD HIS B  308  UNP  A0A1H6AD4           EXPRESSION TAG
SEQADV 6SCD HIS B  309  UNP  A0A1H6AD4           EXPRESSION TAG
SEQADV 6SCD HIS B  310  UNP  A0A1H6AD4           EXPRESSION TAG
SEQADV 6SCD HIS B  311  UNP  A0A1H6AD4           EXPRESSION TAG
SEQADV 6SCD HIS B  312  UNP  A0A1H6AD4           EXPRESSION TAG
SEQRES   1 A  312  MET PRO PHE ASN LYS LYS SER VAL LEU ALA LEU CYS GLY
SEQRES   2 A  312  ALA GLY ALA LEU LEU PHE SER MET SER ALA LEU ALA ASN
SEQRES   3 A  312  ASN PRO ALA PRO THR ASP PRO GLY ASP SER GLY GLY GLY
SEQRES   4 A  312  SER ALA TYR GLN ARG GLY PRO ASP PRO SER VAL SER PHE
SEQRES   5 A  312  LEU GLU ALA ASP ARG GLY GLN TYR SER VAL ARG SER SER
SEQRES   6 A  312  ARG VAL SER SER LEU VAL SER GLY PHE GLY GLY GLY THR
SEQRES   7 A  312  ILE TYR TYR PRO THR GLY THR THR GLY THR MET GLY ALA
SEQRES   8 A  312  VAL VAL VAL ILE PRO GLY PHE VAL SER ALA GLU SER SER
SEQRES   9 A  312  ILE ASP TRP TRP GLY PRO LYS LEU ALA SER TYR GLY PHE
SEQRES  10 A  312  VAL VAL MET THR ILE ASP THR ASN THR GLY PHE ASP GLN
SEQRES  11 A  312  PRO PRO SER ARG ALA ARG GLN ILE ASN ASN ALA LEU ASP
SEQRES  12 A  312  TYR LEU VAL SER GLN ASN SER ARG SER SER SER PRO VAL
SEQRES  13 A  312  ARG GLY MET ILE ASP THR ASN ARG LEU GLY VAL ILE GLY
SEQRES  14 A  312  TRP SER MET GLY GLY GLY GLY THR LEU ARG VAL ALA SER
SEQRES  15 A  312  GLU GLY ARG ILE LYS ALA ALA ILE PRO LEU ALA PRO TRP
SEQRES  16 A  312  ASP THR THR SER TYR TYR ALA SER ARG SER GLN ALA PRO
SEQRES  17 A  312  THR LEU ILE PHE ALA CYS GLU SER ASP VAL ILE ALA PRO
SEQRES  18 A  312  VAL LEU GLN HIS ALA SER PRO PHE TYR ASN SER LEU PRO
SEQRES  19 A  312  SER SER ILE ASP LYS ALA PHE VAL GLU ILE ASN GLY GLY
SEQRES  20 A  312  SER HIS SER CYS GLY ASN GLY GLY SER ILE TYR ASN ASP
SEQRES  21 A  312  VAL LEU SER ARG PHE GLY VAL SER TRP MET LYS LEU HIS
SEQRES  22 A  312  LEU ASP GLU ASP SER ARG TYR LYS GLN PHE LEU CYS GLY
SEQRES  23 A  312  PRO ASN HIS THR SER ASP SER GLN ILE SER ASP TYR ARG
SEQRES  24 A  312  GLY ASN CYS PRO TYR LEU GLU HIS HIS HIS HIS HIS HIS
SEQRES   1 B  312  MET PRO PHE ASN LYS LYS SER VAL LEU ALA LEU CYS GLY
SEQRES   2 B  312  ALA GLY ALA LEU LEU PHE SER MET SER ALA LEU ALA ASN
SEQRES   3 B  312  ASN PRO ALA PRO THR ASP PRO GLY ASP SER GLY GLY GLY
SEQRES   4 B  312  SER ALA TYR GLN ARG GLY PRO ASP PRO SER VAL SER PHE
SEQRES   5 B  312  LEU GLU ALA ASP ARG GLY GLN TYR SER VAL ARG SER SER
SEQRES   6 B  312  ARG VAL SER SER LEU VAL SER GLY PHE GLY GLY GLY THR
SEQRES   7 B  312  ILE TYR TYR PRO THR GLY THR THR GLY THR MET GLY ALA
SEQRES   8 B  312  VAL VAL VAL ILE PRO GLY PHE VAL SER ALA GLU SER SER
SEQRES   9 B  312  ILE ASP TRP TRP GLY PRO LYS LEU ALA SER TYR GLY PHE
SEQRES  10 B  312  VAL VAL MET THR ILE ASP THR ASN THR GLY PHE ASP GLN
SEQRES  11 B  312  PRO PRO SER ARG ALA ARG GLN ILE ASN ASN ALA LEU ASP
SEQRES  12 B  312  TYR LEU VAL SER GLN ASN SER ARG SER SER SER PRO VAL
SEQRES  13 B  312  ARG GLY MET ILE ASP THR ASN ARG LEU GLY VAL ILE GLY
SEQRES  14 B  312  TRP SER MET GLY GLY GLY GLY THR LEU ARG VAL ALA SER
SEQRES  15 B  312  GLU GLY ARG ILE LYS ALA ALA ILE PRO LEU ALA PRO TRP
SEQRES  16 B  312  ASP THR THR SER TYR TYR ALA SER ARG SER GLN ALA PRO
SEQRES  17 B  312  THR LEU ILE PHE ALA CYS GLU SER ASP VAL ILE ALA PRO
SEQRES  18 B  312  VAL LEU GLN HIS ALA SER PRO PHE TYR ASN SER LEU PRO
SEQRES  19 B  312  SER SER ILE ASP LYS ALA PHE VAL GLU ILE ASN GLY GLY
SEQRES  20 B  312  SER HIS SER CYS GLY ASN GLY GLY SER ILE TYR ASN ASP
SEQRES  21 B  312  VAL LEU SER ARG PHE GLY VAL SER TRP MET LYS LEU HIS
SEQRES  22 B  312  LEU ASP GLU ASP SER ARG TYR LYS GLN PHE LEU CYS GLY
SEQRES  23 B  312  PRO ASN HIS THR SER ASP SER GLN ILE SER ASP TYR ARG
SEQRES  24 B  312  GLY ASN CYS PRO TYR LEU GLU HIS HIS HIS HIS HIS HIS
HET    SO4  A 401       5
HET    PO4  A 402       5
HET    PO4  A 403       5
HET     NA  A 404       1
HET     CL  A 405       1
HET     CL  A 406       1
HET    PEG  A 407       7
HET    GOL  A 408       6
HET    GOL  A 409       6
HET    ACT  A 410       4
HET    PO4  B 401       5
HET     NA  B 402       1
HET     NA  B 403       1
HET     CL  B 404       1
HETNAM     SO4 SULFATE ION
HETNAM     PO4 PHOSPHATE ION
HETNAM      NA SODIUM ION
HETNAM      CL CHLORIDE ION
HETNAM     PEG DI(HYDROXYETHYL)ETHER
HETNAM     GOL GLYCEROL
HETNAM     ACT ACETATE ION
HETSYN     GOL GLYCERIN; PROPANE-1,2,3-TRIOL
FORMUL   3  SO4    O4 S 2-
FORMUL   4  PO4    3(O4 P 3-)
FORMUL   6   NA    3(NA 1+)
FORMUL   7   CL    3(CL 1-)
FORMUL   9  PEG    C4 H10 O3
FORMUL  10  GOL    2(C3 H8 O3)
FORMUL  12  ACT    C2 H3 O2 1-
FORMUL  17  HOH   *493(H2 O)
HELIX    1 AA1 SER A   49  ALA A   55  1                                   7
HELIX    2 AA2 ALA A  101  ASP A  106  5                                   6
HELIX    3 AA3 TRP A  107  SER A  114  1                                   8
HELIX    4 AA4 GLN A  130  ASN A  149  1                                  20
HELIX    5 AA5 SER A  171  SER A  182  1                                  12
HELIX    6 AA6 TYR A  201  SER A  205  5                                   5
HELIX    7 AA7 HIS A  225  LEU A  233  1                                   9
HELIX    8 AA8 TYR A  258  ASP A  275  1                                  18
HELIX    9 AA9 ASP A  277  ARG A  279  5                                   3
HELIX   10 AB1 TYR A  280  CYS A  285  1                                   6
HELIX   11 AB2 ASN A  288  ASP A  292  5                                   5
HELIX   12 AB3 SER B   49  ALA B   55  1                                   7
HELIX   13 AB4 ALA B  101  ASP B  106  5                                   6
HELIX   14 AB5 TRP B  107  SER B  114  1                                   8
HELIX   15 AB6 GLN B  130  SER B  150  1                                  21
HELIX   16 AB7 SER B  171  SER B  182  1                                  12
HELIX   17 AB8 SER B  199  ARG B  204  1                                   6
HELIX   18 AB9 HIS B  225  LEU B  233  1                                   9
HELIX   19 AC1 TYR B  258  GLU B  276  1                                  19
HELIX   20 AC2 ASP B  277  ARG B  279  5                                   3
HELIX   21 AC3 TYR B  280  CYS B  285  1                                   6
HELIX   22 AC4 ASN B  288  ASP B  292  5                                   5
SHEET    1 AA1 6 VAL A  62  VAL A  67  0
SHEET    2 AA1 6 GLY A  77  PRO A  82 -1  O  ILE A  79   N  SER A  65
SHEET    3 AA1 6 PHE A 117  ILE A 122 -1  O  VAL A 119   N  TYR A  80
SHEET    4 AA1 6 MET A  89  ILE A  95  1  N  VAL A  92   O  MET A 120
SHEET    5 AA1 6 ILE A 160  TRP A 170  1  O  ASP A 161   N  MET A  89
SHEET    6 AA1 6 ALA A 188  LEU A 192  1  O  LEU A 192   N  GLY A 169
SHEET    1 AA2 3 THR A 209  CYS A 214  0
SHEET    2 AA2 3 LYS A 239  ILE A 244  1  O  ILE A 244   N  ALA A 213
SHEET    3 AA2 3 ILE A 295  GLY A 300 -1  O  ASP A 297   N  GLU A 243
SHEET    1 AA3 6 VAL B  62  VAL B  67  0
SHEET    2 AA3 6 GLY B  77  PRO B  82 -1  O  ILE B  79   N  SER B  65
SHEET    3 AA3 6 VAL B 118  ILE B 122 -1  O  VAL B 119   N  TYR B  80
SHEET    4 AA3 6 MET B  89  ILE B  95  1  N  VAL B  94   O  ILE B 122
SHEET    5 AA3 6 ILE B 160  TRP B 170  1  O  GLY B 166   N  ALA B  91
SHEET    6 AA3 6 ALA B 188  LEU B 192  1  O  LEU B 192   N  GLY B 169
SHEET    1 AA4 3 THR B 209  CYS B 214  0
SHEET    2 AA4 3 LYS B 239  ILE B 244  1  O  ILE B 244   N  ALA B 213
SHEET    3 AA4 3 ILE B 295  GLY B 300 -1  O  ASP B 297   N  GLU B 243
SSBOND   1 CYS A  214    CYS A  251                          1555   1555  2.04
SSBOND   2 CYS A  285    CYS A  302                          1555   1555  2.07
SSBOND   3 CYS B  214    CYS B  251                          1555   1555  2.04
SSBOND   4 CYS B  285    CYS B  302                          1555   1555  2.07
LINK         O   THR A 290                NA    NA A 404     1555   1555  2.36
LINK         O   ASP A 292                NA    NA A 404     1555   1555  2.45
LINK         O   ILE A 295                NA    NA A 404     1555   1555  2.24
LINK         OG  SER B 171                NA    NA B 402     1555   1555  2.87
LINK         O   PRO B 194                NA    NA B 403     1555   1555  2.91
LINK         O   ALA B 220                NA    NA B 403     1555   1555  2.76
LINK        NA    NA A 404                 O   HOH A 607     1555   1555  2.49
LINK        NA    NA A 404                 O   HOH A 693     1555   1555  2.41
LINK        NA    NA A 404                 O   HOH A 714     1555   1555  2.40
LINK        NA    NA B 402                 O   HOH B 606     1555   1555  3.18
LINK        NA    NA B 403                 O   HOH B 607     1555   1555  3.03
CISPEP   1 CYS A  302    PRO A  303          0        -2.97
CISPEP   2 CYS B  302    PRO B  303          0        -0.09
SITE     1 AC1  9 GLY A  73  ASN A 125  ASP A 129  SER A 133
SITE     2 AC1  9 ARG A 136  GLN A 137  HOH A 524  HOH A 553
SITE     3 AC1  9 HOH A 750
SITE     1 AC2  5 PRO A 132  ARG A 179  TYR A 201  HOH A 513
SITE     2 AC2  5 HOH A 571
SITE     1 AC3  4 ARG A  44  GLY A  45  GLN A  59  TYR A  60
SITE     1 AC4  6 THR A 290  ASP A 292  ILE A 295  HOH A 607
SITE     2 AC4  6 HOH A 693  HOH A 714
SITE     1 AC5  3 VAL A 218  HIS A 249  SER B 250
SITE     1 AC6  4 PHE A  98  SER A 171  MET A 172  HOH A 587
SITE     1 AC7  7 LEU A  70  VAL A  99  SER A 100  THR A 124
SITE     2 AC7  7 GLY A 127  HOH A 547  HOH A 580
SITE     1 AC8  7 SER A 235  LYS A 239  GLY A 300  ASN A 301
SITE     2 AC8  7 HOH A 548  HOH A 567  HOH A 779
SITE     1 AC9  5 GLU A  54  HOH A 534  HOH A 670  GLU B 215
SITE     2 AC9  5 SER B 216
SITE     1 AD1  5 SER A 235  SER A 236  ILE A 237  ASP A 238
SITE     2 AD1  5 ASN A 301
SITE     1 AD2  3 HOH A 786  ARG B 179  TYR B 201
SITE     1 AD3  3 PHE B  98  SER B 171  MET B 172
SITE     1 AD4  5 PRO B 194  ALA B 220  HIS B 225  ALA B 226
SITE     2 AD4  5 HOH B 607
SITE     1 AD5  5 HOH A 743  ASP B 217  VAL B 218  HIS B 249
SITE     2 AD5  5 HOH B 558
CRYST1   94.526   98.268  121.233  90.00  90.00  90.00 I 21 21 21   16
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.010579  0.000000  0.000000        0.00000
SCALE2      0.000000  0.010176  0.000000        0.00000
SCALE3      0.000000  0.000000  0.008249        0.00000
TER    2044      LEU A 305
TER    4050      LEU B 305
MASTER      628    0   14   22   18    0   24    6 4537    2   66   48
END