longtext: 6syv-pdb

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HEADER    HYDROLASE                               01-OCT-19   6SYV
TITLE     THE GLUCURONOYL ESTERASE OTCE15A S267A VARIANT FROM OPITUTUS TERRAE IN
TITLE    2 COMPLEX WITH D-GLUCURONATE
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: GLUCURONOYL ESTERASE OTCE15A;
COMPND   3 CHAIN: A;
COMPND   4 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: OPITUTUS TERRAE PB90-1;
SOURCE   3 ORGANISM_TAXID: 452637;
SOURCE   4 GENE: OTER_0116;
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3);
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 469008
KEYWDS    ESTERASE, COMPLEX, BIOMASS, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    S.MAZURKEWICH,J.C.NAVARRO POULSEN,J.LARSBRINK,L.LO LEGGIO
REVDAT   1   27-NOV-19 6SYV    0
JRNL        AUTH   S.MAZURKEWICH,J.C.NAVARRO POULSEN,J.LARSBRINK,L.LO LEGGIO
JRNL        TITL   THE GLUCURONOYL ESTERASE OTCE15A S267A VARIANT FROM OPITUTUS
JRNL        TITL 2 TERRAE IN COMPLEX WITH D-GLUCURONATE
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   2
REMARK   2 RESOLUTION.    1.12 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX 1.15.2_3472
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : NULL
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.12
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 36.22
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.960
REMARK   3   COMPLETENESS FOR RANGE        (%) : 81.7
REMARK   3   NUMBER OF REFLECTIONS             : 102078
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.163
REMARK   3   R VALUE            (WORKING SET) : 0.162
REMARK   3   FREE R VALUE                     : 0.182
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 7.480
REMARK   3   FREE R VALUE TEST SET COUNT      : 7637
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 36.2200 -  3.4800    0.97     3758   307  0.1261 0.1460
REMARK   3     2  3.4800 -  2.7600    0.93     3585   283  0.1313 0.1467
REMARK   3     3  2.7600 -  2.4100    0.95     3633   300  0.1359 0.1559
REMARK   3     4  2.4100 -  2.1900    0.96     3699   295  0.1370 0.1608
REMARK   3     5  2.1900 -  2.0400    0.95     3692   295  0.1380 0.1482
REMARK   3     6  2.0400 -  1.9200    0.95     3668   294  0.1454 0.1627
REMARK   3     7  1.9200 -  1.8200    0.95     3653   300  0.1459 0.1723
REMARK   3     8  1.8200 -  1.7400    0.95     3673   292  0.1582 0.1785
REMARK   3     9  1.7400 -  1.6700    0.96     3662   299  0.1586 0.1688
REMARK   3    10  1.6700 -  1.6200    0.96     3722   298  0.1577 0.1923
REMARK   3    11  1.6200 -  1.5600    0.95     3685   301  0.1652 0.2004
REMARK   3    12  1.5600 -  1.5200    0.95     3657   293  0.1672 0.1914
REMARK   3    13  1.5200 -  1.4800    0.95     3668   294  0.1724 0.1895
REMARK   3    14  1.4800 -  1.4400    0.95     3649   296  0.1924 0.2357
REMARK   3    15  1.4400 -  1.4100    0.94     3654   296  0.2207 0.2454
REMARK   3    16  1.4100 -  1.3800    0.94     3633   295  0.2298 0.2448
REMARK   3    17  1.3800 -  1.3500    0.93     3588   290  0.2390 0.2555
REMARK   3    18  1.3500 -  1.3300    0.94     3610   294  0.2548 0.2729
REMARK   3    19  1.3300 -  1.3000    0.93     3582   291  0.2674 0.3172
REMARK   3    20  1.3000 -  1.2800    0.93     3612   293  0.2974 0.2973
REMARK   3    21  1.2800 -  1.2600    0.91     3512   284  0.3030 0.3197
REMARK   3    22  1.2600 -  1.2400    0.75     2854   232  0.3135 0.3428
REMARK   3    23  1.2400 -  1.2200    0.66     2574   209  0.3118 0.3018
REMARK   3    24  1.2200 -  1.2100    0.60     2306   187  0.3138 0.3223
REMARK   3    25  1.2100 -  1.1900    0.54     2110   171  0.3295 0.3519
REMARK   3    26  1.1900 -  1.1700    0.47     1794   146  0.3206 0.3185
REMARK   3    27  1.1700 -  1.1600    0.46     1797   145  0.3383 0.3614
REMARK   3    28  1.1600 -  1.1500    0.41     1567   128  0.3779 0.4210
REMARK   3    29  1.1500 -  1.1300    0.39     1512   123  0.4052 0.4467
REMARK   3    30  1.1300 -  1.1200    0.34     1332   106  0.4380 0.4535
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : NULL
REMARK   3   SOLVENT RADIUS     : 1.11
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.140
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 24.307
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 13.27
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 18.99
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :  0.009           3435
REMARK   3   ANGLE     :  1.186           4675
REMARK   3   CHIRALITY :  0.082            490
REMARK   3   PLANARITY :  0.009            623
REMARK   3   DIHEDRAL  : 21.697           1252
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 6SYV COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 01-OCT-19.
REMARK 100 THE DEPOSITION ID IS D_1292104587.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 06-OCT-18
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 8.5
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : ESRF
REMARK 200  BEAMLINE                       : ID23-2
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.873127
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : PIXEL
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS PILATUS 2M
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200  DATA SCALING SOFTWARE          : XDS
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 102117
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.120
REMARK 200  RESOLUTION RANGE LOW       (A) : 36.220
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 81.7
REMARK 200  DATA REDUNDANCY                : 3.300
REMARK 200  R MERGE                    (I) : 0.08792
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 6.1200
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.12
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.16
REMARK 200  COMPLETENESS FOR SHELL     (%) : 38.3
REMARK 200  DATA REDUNDANCY IN SHELL       : 3.20
REMARK 200  R MERGE FOR SHELL          (I) : 1.04400
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 0.760
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHENIX 1.15.2_3472
REMARK 200 STARTING MODEL: 6GS0
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 32.32
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 1.82
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: ENZYME MIXED 50/50 WITH RESERVOIR
REMARK 280  SOLUTION CONTAINING MORPHEUS SCREEN SOLUTION G12: 0.1 M
REMARK 280  CARBOXYLIC ACIDS (0.2M SODIUM FORMATE; 0.2M AMMONIUM ACETATE;
REMARK 280  0.2M SODIUM CITRATE TRIBASIC DIHYDRATE; 0.2M SODIUM POTASSIUM
REMARK 280  TARTRATE TETRAHYDRATE; 0.2M SODIUM OXAMATE), 0.1 M BUFFER SYSTEM
REMARK 280  3 PH 8.5 (TRIS; BICINE), AND 50 % V/V PRECIPITANT MIX 4 (25% V/V
REMARK 280  MPD; 25% PEG 1000; 25% W/V PEG 3350)., VAPOR DIFFUSION, SITTING
REMARK 280  DROP, TEMPERATURE 298K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 3420 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 15880 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: 27.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A    12
REMARK 465     GLY A    13
REMARK 465     SER A    14
REMARK 465     SER A    15
REMARK 465     HIS A    16
REMARK 465     HIS A    17
REMARK 465     HIS A    18
REMARK 465     HIS A    19
REMARK 465     HIS A    20
REMARK 465     HIS A    21
REMARK 465     SER A    22
REMARK 465     SER A    23
REMARK 465     GLU A    24
REMARK 465     ASN A    25
REMARK 465     LEU A    26
REMARK 465     TYR A    27
REMARK 465     PHE A    28
REMARK 465     GLN A    29
REMARK 465     GLY A    30
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    ALA A  33       50.71    -95.57
REMARK 500    ARG A  57      -55.51   -124.80
REMARK 500    ARG A  57      -57.64   -120.83
REMARK 500    VAL A  70      -70.25   -124.93
REMARK 500    ASP A 150      110.06    -28.65
REMARK 500    ALA A 224      110.36    -30.63
REMARK 500    ASP A 226     -138.94   -132.89
REMARK 500    ALA A 267     -129.86     60.91
REMARK 500    HIS A 328       43.97   -144.97
REMARK 500    ASP A 360       69.74     65.07
REMARK 500
REMARK 500 REMARK: NULL
REMARK 620
REMARK 620 METAL COORDINATION
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              MG A 501  MG
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 HIS A 303   O
REMARK 620 2 GLU A 305   O    93.5
REMARK 620 3 HOH A 849   O   101.7  98.1
REMARK 620 4 HOH A 613   O    86.0  84.3 171.7
REMARK 620 5 HOH A 913   O   159.2  89.0  98.3  73.7
REMARK 620 6 HOH A 708   O    85.6 153.1 108.4  68.8  83.0
REMARK 620 N                    1     2     3     4     5
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue MG A 501
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO A 502
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO A 503
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO A 504
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO A 505
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO A 506
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO A 507
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO A 508
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO A 509
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO A 510
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO A 511
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO A 512
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue GCU A 513
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue BDP A 514
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue PEG A 515
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue PEG A 516
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue PEG A 517
DBREF  6SYV A   33   432  UNP    B1ZMF4   B1ZMF4_OPITP    33    432
SEQADV 6SYV MET A   12  UNP  B1ZMF4              INITIATING METHIONINE
SEQADV 6SYV GLY A   13  UNP  B1ZMF4              EXPRESSION TAG
SEQADV 6SYV SER A   14  UNP  B1ZMF4              EXPRESSION TAG
SEQADV 6SYV SER A   15  UNP  B1ZMF4              EXPRESSION TAG
SEQADV 6SYV HIS A   16  UNP  B1ZMF4              EXPRESSION TAG
SEQADV 6SYV HIS A   17  UNP  B1ZMF4              EXPRESSION TAG
SEQADV 6SYV HIS A   18  UNP  B1ZMF4              EXPRESSION TAG
SEQADV 6SYV HIS A   19  UNP  B1ZMF4              EXPRESSION TAG
SEQADV 6SYV HIS A   20  UNP  B1ZMF4              EXPRESSION TAG
SEQADV 6SYV HIS A   21  UNP  B1ZMF4              EXPRESSION TAG
SEQADV 6SYV SER A   22  UNP  B1ZMF4              EXPRESSION TAG
SEQADV 6SYV SER A   23  UNP  B1ZMF4              EXPRESSION TAG
SEQADV 6SYV GLU A   24  UNP  B1ZMF4              EXPRESSION TAG
SEQADV 6SYV ASN A   25  UNP  B1ZMF4              EXPRESSION TAG
SEQADV 6SYV LEU A   26  UNP  B1ZMF4              EXPRESSION TAG
SEQADV 6SYV TYR A   27  UNP  B1ZMF4              EXPRESSION TAG
SEQADV 6SYV PHE A   28  UNP  B1ZMF4              EXPRESSION TAG
SEQADV 6SYV GLN A   29  UNP  B1ZMF4              EXPRESSION TAG
SEQADV 6SYV GLY A   30  UNP  B1ZMF4              EXPRESSION TAG
SEQADV 6SYV HIS A   31  UNP  B1ZMF4              EXPRESSION TAG
SEQADV 6SYV SER A   32  UNP  B1ZMF4              EXPRESSION TAG
SEQADV 6SYV ALA A  267  UNP  B1ZMF4    SER   267 ENGINEERED MUTATION
SEQRES   1 A  421  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLU
SEQRES   2 A  421  ASN LEU TYR PHE GLN GLY HIS SER ALA TYR THR LEU PRO
SEQRES   3 A  421  ASP PRO LEU VAL GLY ALA ASP GLY THR ARG VAL HIS ASP
SEQRES   4 A  421  ARG ALA THR TRP GLN HIS ARG ARG ARG PRO GLU LEU LEU
SEQRES   5 A  421  GLN LEU PHE ALA ARG GLU VAL TYR GLY ARG THR PRO LEU
SEQRES   6 A  421  GLY ARG PRO GLU GLY MET VAL PHE LYS VAL THR THR MET
SEQRES   7 A  421  GLU HIS ALA ALA LEU GLY GLY ALA ALA THR ARG LYS GLU
SEQRES   8 A  421  VAL THR VAL ARG PHE GLY ARG ASP PRO ASN ALA PRO SER
SEQRES   9 A  421  MET GLN LEU LEU LEU TYR VAL PRO ASN ALA VAL ILE ALA
SEQRES  10 A  421  ARG ALA GLU ARG ALA PRO VAL PHE LEU GLY LEU ASN PHE
SEQRES  11 A  421  TYR GLY ASN HIS THR VAL HIS THR ASP PRO ALA ILE ALA
SEQRES  12 A  421  LEU SER ALA ARG TRP ILE PRO ALA GLU ALA PRO ASN GLY
SEQRES  13 A  421  ALA ASN HIS ARG ALA THR GLU ALA ALA ARG GLY SER ASP
SEQRES  14 A  421  ALA GLN LYS TRP PRO VAL GLU GLN ILE LEU ALA ARG GLY
SEQRES  15 A  421  TYR ALA VAL ALA THR VAL TYR CYS GLY ASP LEU CYS PRO
SEQRES  16 A  421  ASP ARG PRO ASP GLY LEU ASN ALA SER VAL ALA SER TRP
SEQRES  17 A  421  LEU ASP ALA ALA ALA GLY ASP GLN ARG ALA PRO ASP ALA
SEQRES  18 A  421  TRP GLY ALA ILE GLY VAL TRP ALA TRP GLY LEU SER ARG
SEQRES  19 A  421  ALA LEU ASP TYR LEU GLU THR ASP PRO LEU VAL ASP ALA
SEQRES  20 A  421  SER ARG VAL ALA VAL HIS GLY HIS ALA ARG LEU GLY LYS
SEQRES  21 A  421  ALA ALA LEU TRP ALA GLY ALA GLN ASP ASP ARG PHE ALA
SEQRES  22 A  421  LEU VAL ILE SER ASN GLU SER GLY CYS GLY GLY ALA ALA
SEQRES  23 A  421  LEU SER LYS ARG ILE HIS GLY GLU THR VAL ALA ARG ILE
SEQRES  24 A  421  ASN THR VAL PHE PRO HIS TRP PHE ALA ARG ASN PHE ARG
SEQRES  25 A  421  ARG TYR ASP ASP HIS GLU GLU ALA LEU PRO VAL ASP GLN
SEQRES  26 A  421  HIS GLU LEU LEU ALA LEU VAL ALA PRO ARG PRO LEU TYR
SEQRES  27 A  421  VAL ALA SER ALA GLU ASP ASP ASP TRP ALA ASP PRO ARG
SEQRES  28 A  421  GLY GLU PHE LEU ALA VAL LYS ALA ALA GLU PRO VAL PHE
SEQRES  29 A  421  ARG LEU PHE GLY GLN THR GLY PRO SER GLY GLU ASP VAL
SEQRES  30 A  421  PRO ARG VAL ASN GLU PRO SER GLY GLY ALA LEU ARG TYR
SEQRES  31 A  421  HIS ILE ARG PRO GLY PRO HIS GLY MET THR ALA GLN ASP
SEQRES  32 A  421  TRP ALA PHE TYR LEU ALA PHE ALA ASP GLU TRP LEU LYS
SEQRES  33 A  421  SER ALA LEU PRO ALA
HET     MG  A 501       1
HET    EDO  A 502      10
HET    EDO  A 503      10
HET    EDO  A 504      10
HET    EDO  A 505      10
HET    EDO  A 506      10
HET    EDO  A 507      10
HET    EDO  A 508      10
HET    EDO  A 509      10
HET    EDO  A 510      10
HET    EDO  A 511      10
HET    EDO  A 512      10
HET    GCU  A 513      22
HET    BDP  A 514      22
HET    PEG  A 515      34
HET    PEG  A 516      17
HET    PEG  A 517      17
HETNAM      MG MAGNESIUM ION
HETNAM     EDO 1,2-ETHANEDIOL
HETNAM     GCU D-GLUCURONIC ACID
HETNAM     BDP BETA-D-GLUCOPYRANURONIC ACID
HETNAM     PEG DI(HYDROXYETHYL)ETHER
HETSYN     EDO ETHYLENE GLYCOL
HETSYN     BDP D-GLUCURONIC ACID
FORMUL   2   MG    MG 2+
FORMUL   3  EDO    11(C2 H6 O2)
FORMUL  14  GCU    C6 H10 O7
FORMUL  15  BDP    C6 H10 O7
FORMUL  16  PEG    3(C4 H10 O3)
FORMUL  19  HOH   *368(H2 O)
HELIX    1 AA1 ASP A   50  ARG A   57  1                                   8
HELIX    2 AA2 ARG A   57  VAL A   70  1                                  14
HELIX    3 AA3 LEU A   94  GLY A   96  5                                   3
HELIX    4 AA4 ASN A  124  ARG A  129  1                                   6
HELIX    5 AA5 GLY A  143  VAL A  147  5                                   5
HELIX    6 AA6 THR A  173  ARG A  177  5                                   5
HELIX    7 AA7 ASP A  180  TRP A  184  5                                   5
HELIX    8 AA8 PRO A  185  ARG A  192  1                                   8
HELIX    9 AA9 GLY A  202  LEU A  204  5                                   3
HELIX   10 AB1 ASP A  210  ALA A  214  5                                   5
HELIX   11 AB2 SER A  215  LEU A  220  1                                   6
HELIX   12 AB3 GLY A  234  GLU A  251  1                                  18
HELIX   13 AB4 ALA A  267  ASP A  280  1                                  14
HELIX   14 AB5 LEU A  298  ILE A  302  5                                   5
HELIX   15 AB6 THR A  306  PHE A  314  1                                   9
HELIX   16 AB7 ALA A  319  ASP A  326  5                                   8
HELIX   17 AB8 HIS A  328  LEU A  332  5                                   5
HELIX   18 AB9 ASP A  335  LEU A  342  1                                   8
HELIX   19 AC1 ASP A  356  ALA A  359  5                                   4
HELIX   20 AC2 ASP A  360  PHE A  378  1                                  19
HELIX   21 AC3 THR A  411  LEU A  426  1                                  16
SHEET    1 AA1 9 VAL A  83  ALA A  93  0
SHEET    2 AA1 9 ALA A  98  ARG A 106 -1  O  ARG A 106   N  VAL A  83
SHEET    3 AA1 9 SER A 115  PRO A 123 -1  O  LEU A 118   N  VAL A 103
SHEET    4 AA1 9 ALA A 195  TYR A 200 -1  O  THR A 198   N  LEU A 119
SHEET    5 AA1 9 ALA A 133  ASN A 140  1  N  PRO A 134   O  ALA A 195
SHEET    6 AA1 9 VAL A 256  HIS A 266  1  O  ALA A 262   N  VAL A 135
SHEET    7 AA1 9 LEU A 285  ASN A 289  1  O  ASN A 289   N  GLY A 265
SHEET    8 AA1 9 LEU A 348  ALA A 353  1  O  TYR A 349   N  SER A 288
SHEET    9 AA1 9 LEU A 399  ARG A 404  1  O  ARG A 400   N  VAL A 350
LINK         O   HIS A 303                MG    MG A 501     1555   1555  2.28
LINK         O   GLU A 305                MG    MG A 501     1555   1555  2.20
LINK        MG    MG A 501                 O   HOH A 849     1555   1555  2.38
LINK        MG    MG A 501                 O   HOH A 613     1555   1555  2.59
LINK        MG    MG A 501                 O   HOH A 913     1555   1555  2.45
LINK        MG    MG A 501                 O   HOH A 708     1555   1555  2.42
CISPEP   1 ALA A  344    PRO A  345          0         5.65
SITE     1 AC1  6 HIS A 303  GLU A 305  HOH A 613  HOH A 708
SITE     2 AC1  6 HOH A 849  HOH A 913
SITE     1 AC2  3 PRO A 114  SER A 115  ARG A 158
SITE     1 AC3  8 ARG A  51  ASP A 110  PRO A 111  ASP A 355
SITE     2 AC3  8 ASP A 357  TRP A 358  HOH A 698  HOH A 853
SITE     1 AC4  2 ALA A  43  GLN A 413
SITE     1 AC5  4 LEU A  76  PRO A  79  GLU A  80  HOH A 637
SITE     1 AC6  3 LEU A  36  ASP A  38  HOH A 726
SITE     1 AC7  4 ARG A  57  ALA A 191  ARG A 192  THR A 312
SITE     1 AC8  4 ARG A 192  TYR A 194  ARG A 260  LEU A 426
SITE     1 AC9  6 TRP A 358  HIS A 408  GCU A 513  HOH A 698
SITE     2 AC9  6 HOH A 727  HOH A 771
SITE     1 AD1  2 ALA A  43  GLN A 413
SITE     1 AD2  3 PRO A 345  GLN A 380  TRP A 425
SITE     1 AD3  2 ALA A 130  HOH A 642
SITE     1 AD4 12 ALA A 267  ARG A 268  LYS A 271  GLU A 305
SITE     2 AD4 12 PHE A 314  TRP A 358  HIS A 408  EDO A 509
SITE     3 AD4 12 BDP A 514  HOH A 663  HOH A 771  HOH A 785
SITE     1 AD5 13 ALA A 267  ARG A 268  LYS A 271  GLU A 305
SITE     2 AD5 13 ILE A 310  PHE A 314  TRP A 317  TRP A 358
SITE     3 AD5 13 HIS A 408  GCU A 513  HOH A 663  HOH A 771
SITE     4 AD5 13 HOH A 785
SITE     1 AD6  8 LEU A 212  ASN A 213  SER A 218  ASP A 226
SITE     2 AD6  8 ARG A 228  HOH A 664  HOH A 717  HOH A 723
SITE     1 AD7  1 THR A 312
SITE     1 AD8  5 SER A  32  TYR A  34  THR A  35  LEU A  36
SITE     2 AD8  5 HOH A 877
CRYST1   43.507   44.497   50.367  76.43  66.96  70.22 P 1           1
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.022985 -0.008267 -0.008861        0.00000
SCALE2      0.000000  0.023883 -0.002837        0.00000
SCALE3      0.000000  0.000000  0.021726        0.00000
TER    6338      ALA A 432
MASTER      352    0   17   21    9    0   27    6 3566    1  230   33
END