longtext: 6unw-pdb

content
HEADER    HYDROLASE                               13-OCT-19   6UNW
TITLE     EPOXIDE HYDROLASE FROM AN ENDOPHYTIC STREPTOMYCES
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: SOLUBLE EPOXIDE HYDROLASE;
COMPND   3 CHAIN: A, B, C;
COMPND   4 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: STREPTOMYCES SP. CBMAI 2042;
SOURCE   3 ORGANISM_TAXID: 2305222;
SOURCE   4 GENE: STAN_0072;
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI 'BL21-GOLD(DE3)PLYSS AG';
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 866768
KEYWDS    EPOXIDE HYDROLASE, BIOCATALYSIS, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    C.WILSON,J.C.DOS SANTOS,M.V.B.DIAS
REVDAT   1   16-SEP-20 6UNW    0
JRNL        AUTH   G.D.TORMET-GONZALEZ,C.WILSON,G.S.DE OLIVEIRA,J.C.DOS SANTOS,
JRNL        AUTH 2 L.G.DE OLIVEIRA,M.V.B.DIAS
JRNL        TITL   AN EPOXIDE HYDROLASE FROM ENDOPHYTIC STREPTOMYCES SHOWS
JRNL        TITL 2 UNIQUE STRUCTURAL FEATURES AND WIDE BIOCATALYTIC ACTIVITY.
JRNL        REF    ACTA CRYSTALLOGR D STRUCT     V.  76   868 2020
JRNL        REF  2 BIOL
JRNL        REFN                   ISSN 2059-7983
JRNL        PMID   32876062
JRNL        DOI    10.1107/S2059798320010402
REMARK   2
REMARK   2 RESOLUTION.    2.21 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX 18.1-3865
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : ML
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.21
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 48.52
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.340
REMARK   3   COMPLETENESS FOR RANGE        (%) : 94.9
REMARK   3   NUMBER OF REFLECTIONS             : 64557
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.189
REMARK   3   R VALUE            (WORKING SET) : 0.187
REMARK   3   FREE R VALUE                     : 0.227
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.060
REMARK   3   FREE R VALUE TEST SET COUNT      : 3267
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 48.5200 -  6.2900    0.99     3052   153  0.1754 0.1989
REMARK   3     2  6.2800 -  4.9900    1.00     2934   158  0.1708 0.2111
REMARK   3     3  4.9900 -  4.3600    1.00     2888   145  0.1410 0.1735
REMARK   3     4  4.3600 -  3.9600    1.00     2822   150  0.1417 0.1672
REMARK   3     5  3.9600 -  3.6800    1.00     2854   145  0.1459 0.1707
REMARK   3     6  3.6800 -  3.4600    1.00     2833   137  0.1526 0.2076
REMARK   3     7  3.4600 -  3.2900    1.00     2808   147  0.1637 0.1976
REMARK   3     8  3.2900 -  3.1500    1.00     2792   147  0.1707 0.1731
REMARK   3     9  3.1500 -  3.0200    1.00     2818   144  0.1832 0.2231
REMARK   3    10  3.0200 -  2.9200    1.00     2800   165  0.1923 0.2361
REMARK   3    11  2.9200 -  2.8300    1.00     2762   151  0.1947 0.2375
REMARK   3    12  2.8300 -  2.7500    1.00     2779   145  0.2053 0.2313
REMARK   3    13  2.7500 -  2.6800    1.00     2785   159  0.1981 0.2636
REMARK   3    14  2.6800 -  2.6100    1.00     2765   164  0.2024 0.2318
REMARK   3    15  2.6100 -  2.5500    1.00     2788   136  0.2077 0.2919
REMARK   3    16  2.5500 -  2.5000    1.00     2789   136  0.2079 0.2681
REMARK   3    17  2.5000 -  2.4500    1.00     2766   142  0.2106 0.3179
REMARK   3    18  2.4500 -  2.4000    1.00     2777   141  0.2300 0.2467
REMARK   3    19  2.4000 -  2.3600    0.77     2103   110  0.3808 0.4510
REMARK   3    20  2.3600 -  2.3200    0.38     1026    59  0.6414 0.7722
REMARK   3    21  2.3200 -  2.2800    0.75     2066   121  0.4425 0.4603
REMARK   3    22  2.2800 -  2.2400    1.00     2763   164  0.2685 0.3259
REMARK   3    23  2.2400 -  2.2100    0.93     2520   148  0.2796 0.3401
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL
REMARK   3   SOLVENT RADIUS     : 1.11
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.260
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 21.750
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 39.80
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :   NULL           NULL
REMARK   3   ANGLE     :   NULL           NULL
REMARK   3   CHIRALITY :   NULL           NULL
REMARK   3   PLANARITY :   NULL           NULL
REMARK   3   DIHEDRAL  :   NULL           NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : 1
REMARK   3   TLS GROUP : 1
REMARK   3    SELECTION: ALL
REMARK   3    ORIGIN FOR THE GROUP (A):  20.9343  31.1737   4.9466
REMARK   3    T TENSOR
REMARK   3      T11:   0.1927 T22:   0.2323
REMARK   3      T33:   0.2475 T12:   0.0160
REMARK   3      T13:   0.0130 T23:   0.0381
REMARK   3    L TENSOR
REMARK   3      L11:   0.4160 L22:   0.8666
REMARK   3      L33:   0.3909 L12:  -0.0179
REMARK   3      L13:   0.0178 L23:   0.0295
REMARK   3    S TENSOR
REMARK   3      S11:   0.0279 S12:   0.0486 S13:  -0.0738
REMARK   3      S21:  -0.0478 S22:  -0.0474 S23:  -0.1880
REMARK   3      S31:   0.0539 S32:   0.0847 S33:   0.0213
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : 1
REMARK   3   NCS GROUP : 1
REMARK   3    NCS OPERATOR : 1
REMARK   3     REFERENCE SELECTION: (CHAIN A AND (RESID 16 THROUGH 255 OR
REMARK   3                          RESID 257 THROUGH 334 OR RESID 401))
REMARK   3     SELECTION          : (CHAIN B AND (RESID 16 THROUGH 255 OR
REMARK   3                          RESID 257 THROUGH 334 OR RESID 401))
REMARK   3     ATOM PAIRS NUMBER  : 2904
REMARK   3     RMSD               : NULL
REMARK   3    NCS OPERATOR : 2
REMARK   3     REFERENCE SELECTION: (CHAIN A AND (RESID 16 THROUGH 255 OR
REMARK   3                          RESID 257 THROUGH 334 OR RESID 401))
REMARK   3     SELECTION          : (CHAIN C AND (RESID 16 THROUGH 255 OR
REMARK   3                          RESID 257 THROUGH 334 OR RESID 401))
REMARK   3     ATOM PAIRS NUMBER  : 2904
REMARK   3     RMSD               : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 6UNW COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 14-OCT-19.
REMARK 100 THE DEPOSITION ID IS D_1000244922.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 25-OCT-15
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : NULL
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : LNLS
REMARK 200  BEAMLINE                       : W01B-MX2
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.45
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : PIXEL
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS PILATUS 2M
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200  DATA SCALING SOFTWARE          : AIMLESS 0.2.8
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 67798
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.210
REMARK 200  RESOLUTION RANGE LOW       (A) : 48.520
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.5
REMARK 200  DATA REDUNDANCY                : 17.50
REMARK 200  R MERGE                    (I) : 0.12000
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 21.2000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.21
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.26
REMARK 200  COMPLETENESS FOR SHELL     (%) : 95.0
REMARK 200  DATA REDUNDANCY IN SHELL       : 11.90
REMARK 200  R MERGE FOR SHELL          (I) : 1.24200
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: 2E3J
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 59.87
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 3.07
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: TRIS-CITRATE, VAPOR DIFFUSION, HANGING
REMARK 280  DROP, TEMPERATURE 298K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 41 2 2
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,-Y,Z+1/2
REMARK 290       3555   -Y,X,Z+1/4
REMARK 290       4555   Y,-X,Z+3/4
REMARK 290       5555   -X,Y,-Z
REMARK 290       6555   X,-Y,-Z+1/2
REMARK 290       7555   Y,X,-Z+3/4
REMARK 290       8555   -Y,-X,-Z+1/4
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000      116.51950
REMARK 290   SMTRY1   3  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000       58.25975
REMARK 290   SMTRY1   4  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY2   4 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY3   4  0.000000  0.000000  1.000000      174.77925
REMARK 290   SMTRY1   5 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   5  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   5  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   6  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   6  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   6  0.000000  0.000000 -1.000000      116.51950
REMARK 290   SMTRY1   7  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY2   7  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY3   7  0.000000  0.000000 -1.000000      174.77925
REMARK 290   SMTRY1   8  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY2   8 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY3   8  0.000000  0.000000 -1.000000       58.25975
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: HEXAMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350   BIOMT1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   2  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 375
REMARK 375 SPECIAL POSITION
REMARK 375 THE FOLLOWING ATOMS ARE FOUND TO BE WITHIN 0.15 ANGSTROMS
REMARK 375 OF A SYMMETRY RELATED ATOM AND ARE ASSUMED TO BE ON SPECIAL
REMARK 375 POSITIONS.
REMARK 375
REMARK 375 ATOM RES CSSEQI
REMARK 375      HOH A 567  LIES ON A SPECIAL POSITION.
REMARK 375      HOH A 668  LIES ON A SPECIAL POSITION.
REMARK 375      HOH C 617  LIES ON A SPECIAL POSITION.
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     VAL A     1
REMARK 465     PRO A     2
REMARK 465     GLN A     3
REMARK 465     PRO A     4
REMARK 465     PRO A     5
REMARK 465     THR A     6
REMARK 465     ASP A     7
REMARK 465     ASP A     8
REMARK 465     PRO A     9
REMARK 465     THR A    10
REMARK 465     THR A    11
REMARK 465     PRO A    12
REMARK 465     ALA A    13
REMARK 465     SER A   337
REMARK 465     SER A   338
REMARK 465     VAL A   339
REMARK 465     ASP A   340
REMARK 465     LYS A   341
REMARK 465     LEU A   342
REMARK 465     ALA A   343
REMARK 465     ALA A   344
REMARK 465     ALA A   345
REMARK 465     VAL B     1
REMARK 465     PRO B     2
REMARK 465     GLN B     3
REMARK 465     PRO B     4
REMARK 465     PRO B     5
REMARK 465     THR B     6
REMARK 465     ASP B     7
REMARK 465     ASP B     8
REMARK 465     PRO B     9
REMARK 465     THR B    10
REMARK 465     THR B    11
REMARK 465     PRO B    12
REMARK 465     ALA B    13
REMARK 465     SER B   336
REMARK 465     SER B   337
REMARK 465     SER B   338
REMARK 465     VAL B   339
REMARK 465     ASP B   340
REMARK 465     LYS B   341
REMARK 465     LEU B   342
REMARK 465     ALA B   343
REMARK 465     ALA B   344
REMARK 465     ALA B   345
REMARK 465     LEU B   346
REMARK 465     GLU B   347
REMARK 465     HIS B   348
REMARK 465     HIS B   349
REMARK 465     HIS B   350
REMARK 465     HIS B   351
REMARK 465     HIS B   352
REMARK 465     HIS B   353
REMARK 465     VAL C     1
REMARK 465     PRO C     2
REMARK 465     GLN C     3
REMARK 465     PRO C     4
REMARK 465     PRO C     5
REMARK 465     THR C     6
REMARK 465     ASP C     7
REMARK 465     ASP C     8
REMARK 465     PRO C     9
REMARK 465     THR C    10
REMARK 465     THR C    11
REMARK 465     PRO C    12
REMARK 465     ALA C    13
REMARK 465     GLU C    14
REMARK 465     LYS C    15
REMARK 465     SER C   336
REMARK 465     SER C   337
REMARK 465     SER C   338
REMARK 465     VAL C   339
REMARK 465     ASP C   340
REMARK 465     LYS C   341
REMARK 465     LEU C   342
REMARK 465     ALA C   343
REMARK 465     ALA C   344
REMARK 465     ALA C   345
REMARK 465     LEU C   346
REMARK 465     GLU C   347
REMARK 465     HIS C   348
REMARK 465     HIS C   349
REMARK 465     HIS C   350
REMARK 465     HIS C   351
REMARK 465     HIS C   352
REMARK 465     HIS C   353
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     GLU A 347    CG   CD   OE1  OE2
REMARK 470     ASN B 335    CG   OD1  ND2
REMARK 470     ASN C 335    CG   OD1  ND2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   OH   TYR B   251     O2   CAC B   401              2.01
REMARK 500   OE2  GLU A   321     NH2  ARG A   324              2.06
REMARK 500   O    HOH A   658     O    HOH A   699              2.09
REMARK 500   O    HOH B   515     O    HOH B   584              2.17
REMARK 500   O    HOH A   605     O    HOH A   650              2.17
REMARK 500   O    HOH A   659     O    HOH A   686              2.19
REMARK 500   O    HOH A   681     O    HOH B   660              2.19
REMARK 500   O    HOH C   564     O    HOH C   672              2.19
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS
REMARK 500
REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC
REMARK 500 SYMMETRY ARE IN CLOSE CONTACT.  AN ATOM LOCATED WITHIN 0.15
REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A
REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375
REMARK 500 INSTEAD OF REMARK 500.  ATOMS WITH NON-BLANK ALTERNATE
REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS.
REMARK 500
REMARK 500 DISTANCE CUTOFF:
REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS
REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI  SSYMOP   DISTANCE
REMARK 500   O    HOH B   671     O    HOH C   645     3555     1.87
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION
REMARK 500    GLU C 146   CD    GLU C 146   OE1     0.076
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    ARG B  20   NE  -  CZ  -  NH1 ANGL. DEV. =  -3.6 DEGREES
REMARK 500    ARG B  20   NE  -  CZ  -  NH2 ANGL. DEV. =   4.0 DEGREES
REMARK 500    ARG B 250   NE  -  CZ  -  NH1 ANGL. DEV. =  -3.9 DEGREES
REMARK 500    ASP C 159   C   -  N   -  CA  ANGL. DEV. = -16.6 DEGREES
REMARK 500    ASP C 159   CB  -  CG  -  OD1 ANGL. DEV. =  11.5 DEGREES
REMARK 500    ASP C 159   CB  -  CG  -  OD2 ANGL. DEV. = -20.7 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    GLU A  48     -144.90   -120.48
REMARK 500    ASP A 114     -124.80     55.22
REMARK 500    SER A 138      -49.98     68.34
REMARK 500    ASP A 159      -80.25    -21.60
REMARK 500    ASP A 180       84.46   -170.53
REMARK 500    GLN A 271      157.63    -49.45
REMARK 500    GLU B  48     -146.81   -121.64
REMARK 500    ASP B 114     -124.82     58.52
REMARK 500    SER B 138      -46.46     69.56
REMARK 500    ASP B 180       82.87   -167.76
REMARK 500    GLU C  48     -143.63   -118.99
REMARK 500    ASP C 114     -124.21     57.27
REMARK 500    SER C 138      -47.03     69.64
REMARK 500    ALA C 154      -74.05    -67.98
REMARK 500    ARG C 155       20.23    -67.91
REMARK 500    ASP C 159     -105.40     37.28
REMARK 500    ASP C 180       86.02   -169.73
REMARK 500    GLU C 200      -73.88      1.83
REMARK 500    ARG C 334       55.23    -92.21
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS
REMARK 500
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.
REMARK 500                                 MODEL     OMEGA
REMARK 500 GLY A  158     ASP A  159                  135.34
REMARK 500 GLY C  158     ASP C  159                  103.24
REMARK 500 PRO C  199     GLU C  200                  129.84
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: PLANAR GROUPS
REMARK 500
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS
REMARK 500 AN RMSD GREATER THAN THIS VALUE
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500  M RES CSSEQI        RMS     TYPE
REMARK 500    ARG A 250         0.08    SIDE CHAIN
REMARK 500    ARG B 250         0.08    SIDE CHAIN
REMARK 500    ARG C 155         0.09    SIDE CHAIN
REMARK 500    ASP C 159         0.11    SIDE CHAIN
REMARK 500
REMARK 500 REMARK: NULL
REMARK 525
REMARK 525 SOLVENT
REMARK 525
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 525 NUMBER; I=INSERTION CODE):
REMARK 525
REMARK 525  M RES CSSEQI
REMARK 525    HOH A 709        DISTANCE =  6.14 ANGSTROMS
REMARK 525    HOH A 710        DISTANCE =  7.46 ANGSTROMS
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CAC A 401
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CAC B 401
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CAC C 401
DBREF  6UNW A    1   353  PDB    6UNW     6UNW             1    353
DBREF  6UNW B    1   353  PDB    6UNW     6UNW             1    353
DBREF  6UNW C    1   353  PDB    6UNW     6UNW             1    353
SEQRES   1 A  353  VAL PRO GLN PRO PRO THR ASP ASP PRO THR THR PRO ALA
SEQRES   2 A  353  GLU LYS GLY ALA VAL HIS ARG LEU VAL ASP THR PRO GLY
SEQRES   3 A  353  GLY ARG ILE HIS LEU VAL GLU GLN GLY THR GLY PRO LEU
SEQRES   4 A  353  VAL LEU LEU VAL HIS GLY PHE PRO GLU SER TRP TYR SER
SEQRES   5 A  353  TRP ARG HIS GLN LEU PRO ALA LEU ALA ALA ALA GLY TYR
SEQRES   6 A  353  ARG ALA ALA ALA ILE ASP VAL ARG GLY TYR GLY ARG SER
SEQRES   7 A  353  ALA LYS PRO ALA ALA THR ASP ALA TYR ARG MET LEU ALA
SEQRES   8 A  353  HIS VAL ALA ASP ASN THR ALA VAL VAL HIS ALA LEU GLY
SEQRES   9 A  353  GLU GLU THR ALA THR VAL VAL GLY HIS ASP TRP GLY SER
SEQRES  10 A  353  PRO ILE ALA ALA ASN SER ALA LEU LEU ARG PRO ASP VAL
SEQRES  11 A  353  PHE THR ALA VAL GLY LEU LEU SER VAL PRO TYR ALA PRO
SEQRES  12 A  353  ARG GLY GLU HIS ARG PRO THR ASP GLY PHE ALA ARG ILE
SEQRES  13 A  353  GLY GLY ASP GLU GLU PHE TYR VAL SER TYR PHE GLN ALA
SEQRES  14 A  353  PRO GLY ARG ALA GLU ALA GLU ILE GLU ARG ASP VAL ARG
SEQRES  15 A  353  GLY TRP LEU ALA GLY PHE TYR THR GLY LEU THR GLY GLY
SEQRES  16 A  353  ALA LEU THR PRO GLU GLU HIS GLY ARG LEU PHE PHE VAL
SEQRES  17 A  353  PRO PRO GLY ALA HIS LEU ALA ASP ARG PHE PRO THR GLY
SEQRES  18 A  353  PRO LEU PRO ALA TRP LEU THR GLU ALA ASP LEU ASP VAL
SEQRES  19 A  353  TYR SER GLY GLU PHE GLU ARG SER GLY LEU THR GLY ALA
SEQRES  20 A  353  LEU ASN ARG TYR ARG ASN VAL ASP ARG ASP TRP GLU ASP
SEQRES  21 A  353  LEU ALA ALA TRP HIS GLY ALA PRO ILE THR GLN PRO SER
SEQRES  22 A  353  LEU PHE ILE GLY GLY ALA LEU ASP ALA SER THR THR TRP
SEQRES  23 A  353  MET ALA ASP ALA LEU ASP ALA TYR PRO ALA THR LEU PRO
SEQRES  24 A  353  GLY LEU SER ALA ALA HIS ILE LEU GLU GLY CYS GLY HIS
SEQRES  25 A  353  TRP ILE GLN GLN GLU ARG PRO ASP GLU VAL ASN ARG LEU
SEQRES  26 A  353  LEU THR GLN TRP LEU ASP GLY LEU ARG ASN SER SER SER
SEQRES  27 A  353  VAL ASP LYS LEU ALA ALA ALA LEU GLU HIS HIS HIS HIS
SEQRES  28 A  353  HIS HIS
SEQRES   1 B  353  VAL PRO GLN PRO PRO THR ASP ASP PRO THR THR PRO ALA
SEQRES   2 B  353  GLU LYS GLY ALA VAL HIS ARG LEU VAL ASP THR PRO GLY
SEQRES   3 B  353  GLY ARG ILE HIS LEU VAL GLU GLN GLY THR GLY PRO LEU
SEQRES   4 B  353  VAL LEU LEU VAL HIS GLY PHE PRO GLU SER TRP TYR SER
SEQRES   5 B  353  TRP ARG HIS GLN LEU PRO ALA LEU ALA ALA ALA GLY TYR
SEQRES   6 B  353  ARG ALA ALA ALA ILE ASP VAL ARG GLY TYR GLY ARG SER
SEQRES   7 B  353  ALA LYS PRO ALA ALA THR ASP ALA TYR ARG MET LEU ALA
SEQRES   8 B  353  HIS VAL ALA ASP ASN THR ALA VAL VAL HIS ALA LEU GLY
SEQRES   9 B  353  GLU GLU THR ALA THR VAL VAL GLY HIS ASP TRP GLY SER
SEQRES  10 B  353  PRO ILE ALA ALA ASN SER ALA LEU LEU ARG PRO ASP VAL
SEQRES  11 B  353  PHE THR ALA VAL GLY LEU LEU SER VAL PRO TYR ALA PRO
SEQRES  12 B  353  ARG GLY GLU HIS ARG PRO THR ASP GLY PHE ALA ARG ILE
SEQRES  13 B  353  GLY GLY ASP GLU GLU PHE TYR VAL SER TYR PHE GLN ALA
SEQRES  14 B  353  PRO GLY ARG ALA GLU ALA GLU ILE GLU ARG ASP VAL ARG
SEQRES  15 B  353  GLY TRP LEU ALA GLY PHE TYR THR GLY LEU THR GLY GLY
SEQRES  16 B  353  ALA LEU THR PRO GLU GLU HIS GLY ARG LEU PHE PHE VAL
SEQRES  17 B  353  PRO PRO GLY ALA HIS LEU ALA ASP ARG PHE PRO THR GLY
SEQRES  18 B  353  PRO LEU PRO ALA TRP LEU THR GLU ALA ASP LEU ASP VAL
SEQRES  19 B  353  TYR SER GLY GLU PHE GLU ARG SER GLY LEU THR GLY ALA
SEQRES  20 B  353  LEU ASN ARG TYR ARG ASN VAL ASP ARG ASP TRP GLU ASP
SEQRES  21 B  353  LEU ALA ALA TRP HIS GLY ALA PRO ILE THR GLN PRO SER
SEQRES  22 B  353  LEU PHE ILE GLY GLY ALA LEU ASP ALA SER THR THR TRP
SEQRES  23 B  353  MET ALA ASP ALA LEU ASP ALA TYR PRO ALA THR LEU PRO
SEQRES  24 B  353  GLY LEU SER ALA ALA HIS ILE LEU GLU GLY CYS GLY HIS
SEQRES  25 B  353  TRP ILE GLN GLN GLU ARG PRO ASP GLU VAL ASN ARG LEU
SEQRES  26 B  353  LEU THR GLN TRP LEU ASP GLY LEU ARG ASN SER SER SER
SEQRES  27 B  353  VAL ASP LYS LEU ALA ALA ALA LEU GLU HIS HIS HIS HIS
SEQRES  28 B  353  HIS HIS
SEQRES   1 C  353  VAL PRO GLN PRO PRO THR ASP ASP PRO THR THR PRO ALA
SEQRES   2 C  353  GLU LYS GLY ALA VAL HIS ARG LEU VAL ASP THR PRO GLY
SEQRES   3 C  353  GLY ARG ILE HIS LEU VAL GLU GLN GLY THR GLY PRO LEU
SEQRES   4 C  353  VAL LEU LEU VAL HIS GLY PHE PRO GLU SER TRP TYR SER
SEQRES   5 C  353  TRP ARG HIS GLN LEU PRO ALA LEU ALA ALA ALA GLY TYR
SEQRES   6 C  353  ARG ALA ALA ALA ILE ASP VAL ARG GLY TYR GLY ARG SER
SEQRES   7 C  353  ALA LYS PRO ALA ALA THR ASP ALA TYR ARG MET LEU ALA
SEQRES   8 C  353  HIS VAL ALA ASP ASN THR ALA VAL VAL HIS ALA LEU GLY
SEQRES   9 C  353  GLU GLU THR ALA THR VAL VAL GLY HIS ASP TRP GLY SER
SEQRES  10 C  353  PRO ILE ALA ALA ASN SER ALA LEU LEU ARG PRO ASP VAL
SEQRES  11 C  353  PHE THR ALA VAL GLY LEU LEU SER VAL PRO TYR ALA PRO
SEQRES  12 C  353  ARG GLY GLU HIS ARG PRO THR ASP GLY PHE ALA ARG ILE
SEQRES  13 C  353  GLY GLY ASP GLU GLU PHE TYR VAL SER TYR PHE GLN ALA
SEQRES  14 C  353  PRO GLY ARG ALA GLU ALA GLU ILE GLU ARG ASP VAL ARG
SEQRES  15 C  353  GLY TRP LEU ALA GLY PHE TYR THR GLY LEU THR GLY GLY
SEQRES  16 C  353  ALA LEU THR PRO GLU GLU HIS GLY ARG LEU PHE PHE VAL
SEQRES  17 C  353  PRO PRO GLY ALA HIS LEU ALA ASP ARG PHE PRO THR GLY
SEQRES  18 C  353  PRO LEU PRO ALA TRP LEU THR GLU ALA ASP LEU ASP VAL
SEQRES  19 C  353  TYR SER GLY GLU PHE GLU ARG SER GLY LEU THR GLY ALA
SEQRES  20 C  353  LEU ASN ARG TYR ARG ASN VAL ASP ARG ASP TRP GLU ASP
SEQRES  21 C  353  LEU ALA ALA TRP HIS GLY ALA PRO ILE THR GLN PRO SER
SEQRES  22 C  353  LEU PHE ILE GLY GLY ALA LEU ASP ALA SER THR THR TRP
SEQRES  23 C  353  MET ALA ASP ALA LEU ASP ALA TYR PRO ALA THR LEU PRO
SEQRES  24 C  353  GLY LEU SER ALA ALA HIS ILE LEU GLU GLY CYS GLY HIS
SEQRES  25 C  353  TRP ILE GLN GLN GLU ARG PRO ASP GLU VAL ASN ARG LEU
SEQRES  26 C  353  LEU THR GLN TRP LEU ASP GLY LEU ARG ASN SER SER SER
SEQRES  27 C  353  VAL ASP LYS LEU ALA ALA ALA LEU GLU HIS HIS HIS HIS
SEQRES  28 C  353  HIS HIS
HET    CAC  A 401       5
HET     CL  A 402       1
HET     CL  A 403       1
HET     CL  A 404       1
HET    CAC  B 401       5
HET     CL  B 402       1
HET    CAC  C 401       5
HET     CL  C 402       1
HETNAM     CAC CACODYLATE ION
HETNAM      CL CHLORIDE ION
HETSYN     CAC DIMETHYLARSINATE
FORMUL   4  CAC    3(C2 H6 AS O2 1-)
FORMUL   5   CL    5(CL 1-)
FORMUL  12  HOH   *593(H2 O)
HELIX    1 AA1 SER A   49  ARG A   54  5                                   6
HELIX    2 AA2 HIS A   55  ALA A   63  1                                   9
HELIX    3 AA3 ALA A   83  TYR A   87  5                                   5
HELIX    4 AA4 ARG A   88  LEU A  103  1                                  16
HELIX    5 AA5 TRP A  115  ARG A  127  1                                  13
HELIX    6 AA6 ARG A  148  ILE A  156  1                                   9
HELIX    7 AA7 TYR A  163  PHE A  167  1                                   5
HELIX    8 AA8 GLY A  171  ARG A  179  1                                   9
HELIX    9 AA9 ASP A  180  LEU A  192  1                                  13
HELIX   10 AB1 THR A  198  LEU A  205  1                                   8
HELIX   11 AB2 HIS A  213  PHE A  218  5                                   6
HELIX   12 AB3 THR A  228  GLY A  243  1                                  16
HELIX   13 AB4 LEU A  244  ARG A  252  1                                   9
HELIX   14 AB5 ASN A  253  LEU A  261  1                                   9
HELIX   15 AB6 ALA A  262  HIS A  265  5                                   4
HELIX   16 AB7 ASP A  281  TRP A  286  1                                   6
HELIX   17 AB8 MET A  287  ALA A  293  1                                   7
HELIX   18 AB9 ALA A  293  LEU A  298  1                                   6
HELIX   19 AC1 TRP A  313  ARG A  318  1                                   6
HELIX   20 AC2 ARG A  318  SER A  336  1                                  19
HELIX   21 AC3 SER B   49  ARG B   54  5                                   6
HELIX   22 AC4 HIS B   55  ALA B   63  1                                   9
HELIX   23 AC5 ALA B   83  TYR B   87  5                                   5
HELIX   24 AC6 ARG B   88  LEU B  103  1                                  16
HELIX   25 AC7 TRP B  115  ARG B  127  1                                  13
HELIX   26 AC8 ARG B  148  ILE B  156  1                                   9
HELIX   27 AC9 TYR B  163  PHE B  167  1                                   5
HELIX   28 AD1 GLY B  171  ARG B  179  1                                   9
HELIX   29 AD2 ASP B  180  LEU B  192  1                                  13
HELIX   30 AD3 THR B  198  LEU B  205  1                                   8
HELIX   31 AD4 HIS B  213  PHE B  218  5                                   6
HELIX   32 AD5 THR B  228  GLY B  243  1                                  16
HELIX   33 AD6 LEU B  244  ARG B  252  1                                   9
HELIX   34 AD7 ASN B  253  LEU B  261  1                                   9
HELIX   35 AD8 ALA B  262  HIS B  265  5                                   4
HELIX   36 AD9 ASP B  281  TRP B  286  1                                   6
HELIX   37 AE1 MET B  287  ALA B  293  1                                   7
HELIX   38 AE2 ALA B  293  LEU B  298  1                                   6
HELIX   39 AE3 TRP B  313  ARG B  318  1                                   6
HELIX   40 AE4 ARG B  318  ARG B  334  1                                  17
HELIX   41 AE5 SER C   49  ARG C   54  5                                   6
HELIX   42 AE6 HIS C   55  ALA C   63  1                                   9
HELIX   43 AE7 ALA C   83  TYR C   87  5                                   5
HELIX   44 AE8 ARG C   88  LEU C  103  1                                  16
HELIX   45 AE9 TRP C  115  ARG C  127  1                                  13
HELIX   46 AF1 ARG C  148  ARG C  155  1                                   8
HELIX   47 AF2 TYR C  163  PHE C  167  1                                   5
HELIX   48 AF3 GLY C  171  ARG C  179  1                                   9
HELIX   49 AF4 ASP C  180  LEU C  192  1                                  13
HELIX   50 AF5 THR C  198  PHE C  206  1                                   9
HELIX   51 AF6 HIS C  213  PHE C  218  5                                   6
HELIX   52 AF7 THR C  228  GLY C  243  1                                  16
HELIX   53 AF8 LEU C  244  ARG C  252  1                                   9
HELIX   54 AF9 ASN C  253  LEU C  261  1                                   9
HELIX   55 AG1 ALA C  262  HIS C  265  5                                   4
HELIX   56 AG2 ASP C  281  TRP C  286  1                                   6
HELIX   57 AG3 MET C  287  ALA C  293  1                                   7
HELIX   58 AG4 ALA C  293  LEU C  298  1                                   6
HELIX   59 AG5 TRP C  313  ARG C  318  1                                   6
HELIX   60 AG6 ARG C  318  ARG C  334  1                                  17
SHEET    1 AA1 9 VAL A  18  THR A  24  0
SHEET    2 AA1 9 GLY A  27  GLN A  34 -1  O  ILE A  29   N  VAL A  22
SHEET    3 AA1 9 ARG A  66  ILE A  70 -1  O  ALA A  69   N  VAL A  32
SHEET    4 AA1 9 LEU A  39  VAL A  43  1  N  VAL A  40   O  ARG A  66
SHEET    5 AA1 9 ALA A 108  HIS A 113  1  O  VAL A 111   N  LEU A  41
SHEET    6 AA1 9 PHE A 131  LEU A 137  1  O  GLY A 135   N  VAL A 110
SHEET    7 AA1 9 SER A 273  GLY A 278  1  O  LEU A 274   N  LEU A 136
SHEET    8 AA1 9 LEU A 301  LEU A 307  1  O  SER A 302   N  SER A 273
SHEET    9 AA1 9 HIS A 348  HIS A 351  1  O  HIS A 349   N  ALA A 304
SHEET    1 AA2 2 GLU A 161  PHE A 162  0
SHEET    2 AA2 2 PHE A 207  VAL A 208 -1  O  VAL A 208   N  GLU A 161
SHEET    1 AA3 8 VAL B  18  THR B  24  0
SHEET    2 AA3 8 GLY B  27  GLN B  34 -1  O  GLU B  33   N  VAL B  18
SHEET    3 AA3 8 ARG B  66  ILE B  70 -1  O  ALA B  69   N  VAL B  32
SHEET    4 AA3 8 LEU B  39  VAL B  43  1  N  VAL B  40   O  ARG B  66
SHEET    5 AA3 8 ALA B 108  HIS B 113  1  O  VAL B 111   N  LEU B  41
SHEET    6 AA3 8 PHE B 131  LEU B 137  1  O  LEU B 137   N  GLY B 112
SHEET    7 AA3 8 SER B 273  GLY B 278  1  O  LEU B 274   N  LEU B 136
SHEET    8 AA3 8 LEU B 301  LEU B 307  1  O  HIS B 305   N  PHE B 275
SHEET    1 AA4 2 GLU B 161  PHE B 162  0
SHEET    2 AA4 2 PHE B 207  VAL B 208 -1  O  VAL B 208   N  GLU B 161
SHEET    1 AA5 8 VAL C  18  THR C  24  0
SHEET    2 AA5 8 GLY C  27  GLN C  34 -1  O  GLU C  33   N  VAL C  18
SHEET    3 AA5 8 ARG C  66  ILE C  70 -1  O  ALA C  69   N  VAL C  32
SHEET    4 AA5 8 LEU C  39  VAL C  43  1  N  LEU C  42   O  ALA C  68
SHEET    5 AA5 8 ALA C 108  HIS C 113  1  O  VAL C 111   N  LEU C  41
SHEET    6 AA5 8 PHE C 131  LEU C 137  1  O  LEU C 137   N  GLY C 112
SHEET    7 AA5 8 SER C 273  GLY C 278  1  O  LEU C 274   N  LEU C 136
SHEET    8 AA5 8 LEU C 301  LEU C 307  1  O  SER C 302   N  SER C 273
SHEET    1 AA6 2 GLU C 161  PHE C 162  0
SHEET    2 AA6 2 PHE C 207  VAL C 208 -1  O  VAL C 208   N  GLU C 161
CISPEP   1 PHE A   46    PRO A   47          0        -8.86
CISPEP   2 PHE B   46    PRO B   47          0        -9.64
CISPEP   3 PHE C   46    PRO C   47          0        -9.52
SITE     1 AC1  5 ASP A 114  TRP A 115  TYR A 163  TYR A 251
SITE     2 AC1  5 SER A 283
SITE     1 AC2  7 PHE B  46  ASP B 114  TYR B 163  PHE B 206
SITE     2 AC2  7 TYR B 251  HIS B 312  HOH B 504
SITE     1 AC3  7 PHE C  46  ASP C 114  TRP C 115  TYR C 163
SITE     2 AC3  7 TYR C 251  SER C 283  HIS C 312
CRYST1  106.733  106.733  233.039  90.00  90.00  90.00 P 41 2 2     24
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.009369  0.000000  0.000000        0.00000
SCALE2      0.000000  0.009369  0.000000        0.00000
SCALE3      0.000000  0.000000  0.004291        0.00000
TER    2554      HIS A 353
TER    5026      ASN B 335
TER    7488      ASN C 335
MASTER      545    0    8   60   31    0    6    6 8090    3   15   84
END