longtext: 6wpy-pdb

content
HEADER    HYDROLASE                               28-APR-20   6WPY
TITLE     CRYSTAL STRUCTURE OF BACILLUS LICHENIFORMIS LIPASE BLEST2 IN MATURE
TITLE    2 FORM
CAVEAT     6WPY    THERE IS A DIFFERENCE OF RFREE VALUES: REPORTED (0.2580)
CAVEAT   2 6WPY    CALCULATED (0.2787).
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: BLEST2;
COMPND   3 CHAIN: A, B, C, D, E, F;
COMPND   4 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: BACILLUS LICHENIFORMIS;
SOURCE   3 ORGANISM_TAXID: 1402;
SOURCE   4 GENE: DW032_06865;
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 562
KEYWDS    ESTERASE, LIPASE, PROPETIDE, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    A.M.NAKAMURA,A.S.GODOY,M.A.S.KADOWAKI,I.POLIKARPOV
REVDAT   1   09-JUN-21 6WPY    0
JRNL        AUTH   A.M.NAKAMURA,A.S.GODOY,M.A.S.KADOWAKI,I.POLIKARPOV
JRNL        TITL   THE FIRST STRUCTURE OF BACILLUS LICHENIFORMIS LIPASE BLEST2
JRNL        TITL 2 IN ITS PROPEPTIDE AND MATURE FORM REVEALING MOLECULAR
JRNL        TITL 3 DETAILS OF INHIBITION BY ITS C-TERMINAL DOMAINS
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   2
REMARK   2 RESOLUTION.    3.60 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : BUSTER 2.10.3
REMARK   3   AUTHORS     : BRICOGNE,BLANC,BRANDL,FLENSBURG,KELLER,
REMARK   3               : PACIOREK,ROVERSI,SHARFF,SMART,VONRHEIN,
REMARK   3               : WOMACK,MATTHEWS,TEN EYCK,TRONRUD
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 3.60
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 40.49
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0.000
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.9
REMARK   3   NUMBER OF REFLECTIONS             : 23568
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD           : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION   : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET)  : 0.216
REMARK   3   R VALUE            (WORKING SET)  : 0.214
REMARK   3   FREE R VALUE                      : 0.258
REMARK   3   FREE R VALUE TEST SET SIZE   (%)  : 5.100
REMARK   3   FREE R VALUE TEST SET COUNT       : 1202
REMARK   3   ESTIMATED ERROR OF FREE R VALUE   : 0.000
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED               : 12
REMARK   3   BIN RESOLUTION RANGE HIGH   (ANGSTROMS) : 3.60
REMARK   3   BIN RESOLUTION RANGE LOW    (ANGSTROMS) : 3.76
REMARK   3   BIN COMPLETENESS (WORKING+TEST)     (%) : 99.93
REMARK   3   REFLECTIONS IN BIN (WORKING + TEST SET) : 2830
REMARK   3   BIN R VALUE        (WORKING + TEST SET) : 0.2350
REMARK   3   REFLECTIONS IN BIN        (WORKING SET) : 2693
REMARK   3   BIN R VALUE               (WORKING SET) : 0.2330
REMARK   3   BIN FREE R VALUE                        : 0.2740
REMARK   3   BIN FREE R VALUE TEST SET SIZE      (%) : 4.84
REMARK   3   BIN FREE R VALUE TEST SET COUNT         : 137
REMARK   3   ESTIMATED ERROR OF BIN FREE R VALUE     : 0.000
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 11580
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 0
REMARK   3   SOLVENT ATOMS            : 279
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 38.11
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : -10.03860
REMARK   3    B22 (A**2) : -7.48260
REMARK   3    B33 (A**2) : 17.52120
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : 0.00000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  ESTIMATED COORDINATE ERROR.
REMARK   3   ESD FROM LUZZATI PLOT                    (A) : 0.500
REMARK   3   DPI (BLOW EQ-10) BASED ON R VALUE        (A) : NULL
REMARK   3   DPI (BLOW EQ-9) BASED ON FREE R VALUE    (A) : 0.652
REMARK   3   DPI (CRUICKSHANK) BASED ON R VALUE       (A) : NULL
REMARK   3   DPI (CRUICKSHANK) BASED ON FREE R VALUE  (A) : NULL
REMARK   3
REMARK   3   REFERENCES: BLOW, D. (2002) ACTA CRYST D58, 792-797
REMARK   3               CRUICKSHANK, D.W.J. (1999) ACTA CRYST D55, 583-601
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.806
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.764
REMARK   3
REMARK   3   NUMBER OF GEOMETRIC FUNCTION TERMS DEFINED : 15
REMARK   3   TERM                          COUNT    WEIGHT   FUNCTION.
REMARK   3    BOND LENGTHS              : 11976  ; 2.000  ; HARMONIC
REMARK   3    BOND ANGLES               : 16278  ; 2.000  ; HARMONIC
REMARK   3    TORSION ANGLES            : 3912   ; 2.000  ; SINUSOIDAL
REMARK   3    TRIGONAL CARBON PLANES    : 300    ; 2.000  ; HARMONIC
REMARK   3    GENERAL PLANES            : 1770   ; 5.000  ; HARMONIC
REMARK   3    ISOTROPIC THERMAL FACTORS : 11976  ; 20.000 ; HARMONIC
REMARK   3    BAD NON-BONDED CONTACTS   : NULL   ; NULL   ; NULL
REMARK   3    IMPROPER TORSIONS         : NULL   ; NULL   ; NULL
REMARK   3    PSEUDOROTATION ANGLES     : NULL   ; NULL   ; NULL
REMARK   3    CHIRAL IMPROPER TORSION   : 1464   ; 5.000  ; SEMIHARMONIC
REMARK   3    SUM OF OCCUPANCIES        : NULL   ; NULL   ; NULL
REMARK   3    UTILITY DISTANCES         : NULL   ; NULL   ; NULL
REMARK   3    UTILITY ANGLES            : NULL   ; NULL   ; NULL
REMARK   3    UTILITY TORSION           : NULL   ; NULL   ; NULL
REMARK   3    IDEAL-DIST CONTACT TERM   : 14600  ; 4.000  ; SEMIHARMONIC
REMARK   3
REMARK   3   RMS DEVIATIONS FROM IDEAL VALUES.
REMARK   3    BOND LENGTHS                       (A) : 0.010
REMARK   3    BOND ANGLES                  (DEGREES) : 1.08
REMARK   3    PEPTIDE OMEGA TORSION ANGLES (DEGREES) : 2.83
REMARK   3    OTHER TORSION ANGLES         (DEGREES) : 19.40
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 6WPY COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 29-APR-20.
REMARK 100 THE DEPOSITION ID IS D_1000248805.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 27-JUN-19
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : NULL
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : LNLS
REMARK 200  BEAMLINE                       : W01B-MX2
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.4585
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : PIXEL
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS PILATUS 2M
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200  DATA SCALING SOFTWARE          : AIMLESS
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 23568
REMARK 200  RESOLUTION RANGE HIGH      (A) : 3.600
REMARK 200  RESOLUTION RANGE LOW       (A) : 40.490
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.3
REMARK 200  DATA REDUNDANCY                : 6.400
REMARK 200  R MERGE                    (I) : NULL
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 4.8000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 3.60
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 3.70
REMARK 200  COMPLETENESS FOR SHELL     (%) : NULL
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL
REMARK 200  R MERGE FOR SHELL          (I) : NULL
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 1.800
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: 6WPX
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 19.67
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 1.53
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.1 M MMT PH 5.0 AND 25% (W/V) PEG
REMARK 280  1500, VAPOR DIFFUSION, TEMPERATURE 291K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 2 21
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,Y,-Z
REMARK 290       3555   X+1/2,-Y,-Z+1/2
REMARK 290       4555   -X+1/2,-Y,Z+1/2
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   3  1.000000  0.000000  0.000000       51.03850
REMARK 290   SMTRY2   3  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       78.96000
REMARK 290   SMTRY1   4 -1.000000  0.000000  0.000000       51.03850
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   4  0.000000  0.000000  1.000000       78.96000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2, 3, 4, 5, 6
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 3
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 4
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: D
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 5
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: E
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 6
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: F
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A     1
REMARK 465     LYS A     2
REMARK 465     LYS A     3
REMARK 465     LEU A     4
REMARK 465     VAL A     5
REMARK 465     LEU A     6
REMARK 465     LEU A     7
REMARK 465     MET A     8
REMARK 465     LEU A     9
REMARK 465     VAL A    10
REMARK 465     LEU A    11
REMARK 465     LEU A    12
REMARK 465     LEU A    13
REMARK 465     VAL A    14
REMARK 465     TYR A    15
REMARK 465     PRO A    16
REMARK 465     HIS A    17
REMARK 465     VAL A    18
REMARK 465     SER A    19
REMARK 465     LYS A    20
REMARK 465     ALA A    21
REMARK 465     GLY A    22
REMARK 465     GLY A    23
REMARK 465     PHE A    24
REMARK 465     LYS A    25
REMARK 465     GLY A    26
REMARK 465     GLY A    27
REMARK 465     GLY A    28
REMARK 465     GLN A   274
REMARK 465     ALA A   275
REMARK 465     ASN A   276
REMARK 465     ALA A   277
REMARK 465     ASN A   278
REMARK 465     GLU A   279
REMARK 465     THR A   280
REMARK 465     ALA A   281
REMARK 465     ALA A   282
REMARK 465     THR A   283
REMARK 465     LYS A   284
REMARK 465     GLU A   285
REMARK 465     ASN A   286
REMARK 465     LEU A   287
REMARK 465     SER A   288
REMARK 465     TYR A   289
REMARK 465     PRO A   290
REMARK 465     PHE A   291
REMARK 465     ILE A   292
REMARK 465     ARG A   293
REMARK 465     GLY A   294
REMARK 465     GLY A   295
REMARK 465     GLU A   296
REMARK 465     ASN A   297
REMARK 465     HIS A   298
REMARK 465     GLY A   299
REMARK 465     LEU A   300
REMARK 465     ARG A   301
REMARK 465     GLU A   302
REMARK 465     GLU A   303
REMARK 465     GLU A   304
REMARK 465     PHE A   305
REMARK 465     ALA A   306
REMARK 465     VAL A   307
REMARK 465     GLU A   308
REMARK 465     LYS A   309
REMARK 465     GLY A   310
REMARK 465     VAL A   311
REMARK 465     LYS A   312
REMARK 465     GLU A   313
REMARK 465     ILE A   314
REMARK 465     THR A   315
REMARK 465     VAL A   316
REMARK 465     HIS A   317
REMARK 465     TRP A   318
REMARK 465     LEU A   319
REMARK 465     SER A   320
REMARK 465     ASN A   321
REMARK 465     HIS A   322
REMARK 465     SER A   323
REMARK 465     SER A   324
REMARK 465     GLY A   325
REMARK 465     ASN A   326
REMARK 465     ILE A   327
REMARK 465     LYS A   328
REMARK 465     LEU A   329
REMARK 465     THR A   330
REMARK 465     ASP A   331
REMARK 465     PRO A   332
REMARK 465     ARG A   333
REMARK 465     GLY A   334
REMARK 465     LYS A   335
REMARK 465     PRO A   336
REMARK 465     PHE A   337
REMARK 465     LYS A   338
REMARK 465     ASP A   339
REMARK 465     PHE A   340
REMARK 465     SER A   341
REMARK 465     ILE A   342
REMARK 465     ALA A   343
REMARK 465     LYS A   344
REMARK 465     THR A   345
REMARK 465     ALA A   346
REMARK 465     ASP A   347
REMARK 465     VAL A   348
REMARK 465     PHE A   349
REMARK 465     GLU A   350
REMARK 465     GLY A   351
REMARK 465     GLY A   352
REMARK 465     PHE A   353
REMARK 465     VAL A   354
REMARK 465     HIS A   355
REMARK 465     SER A   356
REMARK 465     ALA A   357
REMARK 465     ALA A   358
REMARK 465     ILE A   359
REMARK 465     LYS A   360
REMARK 465     ASN A   361
REMARK 465     PRO A   362
REMARK 465     ALA A   363
REMARK 465     ALA A   364
REMARK 465     GLY A   365
REMARK 465     THR A   366
REMARK 465     TRP A   367
REMARK 465     LYS A   368
REMARK 465     ILE A   369
REMARK 465     ALA A   370
REMARK 465     SER A   371
REMARK 465     SER A   372
REMARK 465     VAL A   373
REMARK 465     LYS A   374
REMARK 465     GLN A   375
REMARK 465     LYS A   376
REMARK 465     GLU A   377
REMARK 465     ALA A   378
REMARK 465     PHE A   379
REMARK 465     LEU A   380
REMARK 465     PHE A   381
REMARK 465     ILE A   382
REMARK 465     VAL A   383
REMARK 465     THR A   384
REMARK 465     PHE A   385
REMARK 465     ASP A   386
REMARK 465     SER A   387
REMARK 465     PRO A   388
REMARK 465     LEU A   389
REMARK 465     ASN A   390
REMARK 465     GLN A   391
REMARK 465     GLN A   392
REMARK 465     ILE A   393
REMARK 465     LYS A   394
REMARK 465     ASN A   395
REMARK 465     ALA A   396
REMARK 465     VAL A   397
REMARK 465     THR A   398
REMARK 465     ARG A   399
REMARK 465     GLU A   400
REMARK 465     SER A   401
REMARK 465     SER A   402
REMARK 465     ASN A   403
REMARK 465     LEU A   404
REMARK 465     ALA A   405
REMARK 465     ASN A   406
REMARK 465     VAL A   407
REMARK 465     LYS A   408
REMARK 465     ALA A   409
REMARK 465     SER A   410
REMARK 465     VAL A   411
REMARK 465     ARG A   412
REMARK 465     SER A   413
REMARK 465     ILE A   414
REMARK 465     ARG A   415
REMARK 465     TYR A   416
REMARK 465     GLU A   417
REMARK 465     ASN A   418
REMARK 465     GLY A   419
REMARK 465     LYS A   420
REMARK 465     GLN A   421
REMARK 465     ALA A   422
REMARK 465     GLU A   423
REMARK 465     LYS A   424
REMARK 465     LYS A   425
REMARK 465     SER A   426
REMARK 465     LEU A   427
REMARK 465     LYS A   428
REMARK 465     PRO A   429
REMARK 465     ALA A   430
REMARK 465     SER A   431
REMARK 465     ILE A   432
REMARK 465     ASN A   433
REMARK 465     ALA A   434
REMARK 465     LEU A   435
REMARK 465     GLN A   436
REMARK 465     ASN A   437
REMARK 465     SER A   438
REMARK 465     LEU A   439
REMARK 465     SER A   440
REMARK 465     PHE A   441
REMARK 465     LYS A   442
REMARK 465     LYS A   443
REMARK 465     ALA A   444
REMARK 465     GLY A   445
REMARK 465     MET A   446
REMARK 465     TYR A   447
REMARK 465     SER A   448
REMARK 465     VAL A   449
REMARK 465     THR A   450
REMARK 465     ILE A   451
REMARK 465     ASP A   452
REMARK 465     LEU A   453
REMARK 465     SER A   454
REMARK 465     GLY A   455
REMARK 465     LYS A   456
REMARK 465     THR A   457
REMARK 465     ALA A   458
REMARK 465     ASP A   459
REMARK 465     ASN A   460
REMARK 465     SER A   461
REMARK 465     PRO A   462
REMARK 465     PHE A   463
REMARK 465     ASN A   464
REMARK 465     ARG A   465
REMARK 465     THR A   466
REMARK 465     ILE A   467
REMARK 465     ILE A   468
REMARK 465     ARG A   469
REMARK 465     SER A   470
REMARK 465     ILE A   471
REMARK 465     TYR A   472
REMARK 465     VAL A   473
REMARK 465     ASN A   474
REMARK 465     ASP A   475
REMARK 465     LYS A   476
REMARK 465     GLY A   477
REMARK 465     GLU A   478
REMARK 465     LYS A   479
REMARK 465     PHE A   480
REMARK 465     GLU A   481
REMARK 465     ASN A   482
REMARK 465     SER A   483
REMARK 465     PRO A   484
REMARK 465     LEU A   485
REMARK 465     SER A   486
REMARK 465     ASP A   487
REMARK 465     MET B     1
REMARK 465     LYS B     2
REMARK 465     LYS B     3
REMARK 465     LEU B     4
REMARK 465     VAL B     5
REMARK 465     LEU B     6
REMARK 465     LEU B     7
REMARK 465     MET B     8
REMARK 465     LEU B     9
REMARK 465     VAL B    10
REMARK 465     LEU B    11
REMARK 465     LEU B    12
REMARK 465     LEU B    13
REMARK 465     VAL B    14
REMARK 465     TYR B    15
REMARK 465     PRO B    16
REMARK 465     HIS B    17
REMARK 465     VAL B    18
REMARK 465     SER B    19
REMARK 465     LYS B    20
REMARK 465     ALA B    21
REMARK 465     GLY B    22
REMARK 465     GLY B    23
REMARK 465     PHE B    24
REMARK 465     LYS B    25
REMARK 465     GLY B    26
REMARK 465     GLY B    27
REMARK 465     GLY B    28
REMARK 465     GLN B   274
REMARK 465     ALA B   275
REMARK 465     ASN B   276
REMARK 465     ALA B   277
REMARK 465     ASN B   278
REMARK 465     GLU B   279
REMARK 465     THR B   280
REMARK 465     ALA B   281
REMARK 465     ALA B   282
REMARK 465     THR B   283
REMARK 465     LYS B   284
REMARK 465     GLU B   285
REMARK 465     ASN B   286
REMARK 465     LEU B   287
REMARK 465     SER B   288
REMARK 465     TYR B   289
REMARK 465     PRO B   290
REMARK 465     PHE B   291
REMARK 465     ILE B   292
REMARK 465     ARG B   293
REMARK 465     GLY B   294
REMARK 465     GLY B   295
REMARK 465     GLU B   296
REMARK 465     ASN B   297
REMARK 465     HIS B   298
REMARK 465     GLY B   299
REMARK 465     LEU B   300
REMARK 465     ARG B   301
REMARK 465     GLU B   302
REMARK 465     GLU B   303
REMARK 465     GLU B   304
REMARK 465     PHE B   305
REMARK 465     ALA B   306
REMARK 465     VAL B   307
REMARK 465     GLU B   308
REMARK 465     LYS B   309
REMARK 465     GLY B   310
REMARK 465     VAL B   311
REMARK 465     LYS B   312
REMARK 465     GLU B   313
REMARK 465     ILE B   314
REMARK 465     THR B   315
REMARK 465     VAL B   316
REMARK 465     HIS B   317
REMARK 465     TRP B   318
REMARK 465     LEU B   319
REMARK 465     SER B   320
REMARK 465     ASN B   321
REMARK 465     HIS B   322
REMARK 465     SER B   323
REMARK 465     SER B   324
REMARK 465     GLY B   325
REMARK 465     ASN B   326
REMARK 465     ILE B   327
REMARK 465     LYS B   328
REMARK 465     LEU B   329
REMARK 465     THR B   330
REMARK 465     ASP B   331
REMARK 465     PRO B   332
REMARK 465     ARG B   333
REMARK 465     GLY B   334
REMARK 465     LYS B   335
REMARK 465     PRO B   336
REMARK 465     PHE B   337
REMARK 465     LYS B   338
REMARK 465     ASP B   339
REMARK 465     PHE B   340
REMARK 465     SER B   341
REMARK 465     ILE B   342
REMARK 465     ALA B   343
REMARK 465     LYS B   344
REMARK 465     THR B   345
REMARK 465     ALA B   346
REMARK 465     ASP B   347
REMARK 465     VAL B   348
REMARK 465     PHE B   349
REMARK 465     GLU B   350
REMARK 465     GLY B   351
REMARK 465     GLY B   352
REMARK 465     PHE B   353
REMARK 465     VAL B   354
REMARK 465     HIS B   355
REMARK 465     SER B   356
REMARK 465     ALA B   357
REMARK 465     ALA B   358
REMARK 465     ILE B   359
REMARK 465     LYS B   360
REMARK 465     ASN B   361
REMARK 465     PRO B   362
REMARK 465     ALA B   363
REMARK 465     ALA B   364
REMARK 465     GLY B   365
REMARK 465     THR B   366
REMARK 465     TRP B   367
REMARK 465     LYS B   368
REMARK 465     ILE B   369
REMARK 465     ALA B   370
REMARK 465     SER B   371
REMARK 465     SER B   372
REMARK 465     VAL B   373
REMARK 465     LYS B   374
REMARK 465     GLN B   375
REMARK 465     LYS B   376
REMARK 465     GLU B   377
REMARK 465     ALA B   378
REMARK 465     PHE B   379
REMARK 465     LEU B   380
REMARK 465     PHE B   381
REMARK 465     ILE B   382
REMARK 465     VAL B   383
REMARK 465     THR B   384
REMARK 465     PHE B   385
REMARK 465     ASP B   386
REMARK 465     SER B   387
REMARK 465     PRO B   388
REMARK 465     LEU B   389
REMARK 465     ASN B   390
REMARK 465     GLN B   391
REMARK 465     GLN B   392
REMARK 465     ILE B   393
REMARK 465     LYS B   394
REMARK 465     ASN B   395
REMARK 465     ALA B   396
REMARK 465     VAL B   397
REMARK 465     THR B   398
REMARK 465     ARG B   399
REMARK 465     GLU B   400
REMARK 465     SER B   401
REMARK 465     SER B   402
REMARK 465     ASN B   403
REMARK 465     LEU B   404
REMARK 465     ALA B   405
REMARK 465     ASN B   406
REMARK 465     VAL B   407
REMARK 465     LYS B   408
REMARK 465     ALA B   409
REMARK 465     SER B   410
REMARK 465     VAL B   411
REMARK 465     ARG B   412
REMARK 465     SER B   413
REMARK 465     ILE B   414
REMARK 465     ARG B   415
REMARK 465     TYR B   416
REMARK 465     GLU B   417
REMARK 465     ASN B   418
REMARK 465     GLY B   419
REMARK 465     LYS B   420
REMARK 465     GLN B   421
REMARK 465     ALA B   422
REMARK 465     GLU B   423
REMARK 465     LYS B   424
REMARK 465     LYS B   425
REMARK 465     SER B   426
REMARK 465     LEU B   427
REMARK 465     LYS B   428
REMARK 465     PRO B   429
REMARK 465     ALA B   430
REMARK 465     SER B   431
REMARK 465     ILE B   432
REMARK 465     ASN B   433
REMARK 465     ALA B   434
REMARK 465     LEU B   435
REMARK 465     GLN B   436
REMARK 465     ASN B   437
REMARK 465     SER B   438
REMARK 465     LEU B   439
REMARK 465     SER B   440
REMARK 465     PHE B   441
REMARK 465     LYS B   442
REMARK 465     LYS B   443
REMARK 465     ALA B   444
REMARK 465     GLY B   445
REMARK 465     MET B   446
REMARK 465     TYR B   447
REMARK 465     SER B   448
REMARK 465     VAL B   449
REMARK 465     THR B   450
REMARK 465     ILE B   451
REMARK 465     ASP B   452
REMARK 465     LEU B   453
REMARK 465     SER B   454
REMARK 465     GLY B   455
REMARK 465     LYS B   456
REMARK 465     THR B   457
REMARK 465     ALA B   458
REMARK 465     ASP B   459
REMARK 465     ASN B   460
REMARK 465     SER B   461
REMARK 465     PRO B   462
REMARK 465     PHE B   463
REMARK 465     ASN B   464
REMARK 465     ARG B   465
REMARK 465     THR B   466
REMARK 465     ILE B   467
REMARK 465     ILE B   468
REMARK 465     ARG B   469
REMARK 465     SER B   470
REMARK 465     ILE B   471
REMARK 465     TYR B   472
REMARK 465     VAL B   473
REMARK 465     ASN B   474
REMARK 465     ASP B   475
REMARK 465     LYS B   476
REMARK 465     GLY B   477
REMARK 465     GLU B   478
REMARK 465     LYS B   479
REMARK 465     PHE B   480
REMARK 465     GLU B   481
REMARK 465     ASN B   482
REMARK 465     SER B   483
REMARK 465     PRO B   484
REMARK 465     LEU B   485
REMARK 465     SER B   486
REMARK 465     ASP B   487
REMARK 465     MET C     1
REMARK 465     LYS C     2
REMARK 465     LYS C     3
REMARK 465     LEU C     4
REMARK 465     VAL C     5
REMARK 465     LEU C     6
REMARK 465     LEU C     7
REMARK 465     MET C     8
REMARK 465     LEU C     9
REMARK 465     VAL C    10
REMARK 465     LEU C    11
REMARK 465     LEU C    12
REMARK 465     LEU C    13
REMARK 465     VAL C    14
REMARK 465     TYR C    15
REMARK 465     PRO C    16
REMARK 465     HIS C    17
REMARK 465     VAL C    18
REMARK 465     SER C    19
REMARK 465     LYS C    20
REMARK 465     ALA C    21
REMARK 465     GLY C    22
REMARK 465     GLY C    23
REMARK 465     PHE C    24
REMARK 465     LYS C    25
REMARK 465     GLY C    26
REMARK 465     GLY C    27
REMARK 465     GLY C    28
REMARK 465     GLN C   274
REMARK 465     ALA C   275
REMARK 465     ASN C   276
REMARK 465     ALA C   277
REMARK 465     ASN C   278
REMARK 465     GLU C   279
REMARK 465     THR C   280
REMARK 465     ALA C   281
REMARK 465     ALA C   282
REMARK 465     THR C   283
REMARK 465     LYS C   284
REMARK 465     GLU C   285
REMARK 465     ASN C   286
REMARK 465     LEU C   287
REMARK 465     SER C   288
REMARK 465     TYR C   289
REMARK 465     PRO C   290
REMARK 465     PHE C   291
REMARK 465     ILE C   292
REMARK 465     ARG C   293
REMARK 465     GLY C   294
REMARK 465     GLY C   295
REMARK 465     GLU C   296
REMARK 465     ASN C   297
REMARK 465     HIS C   298
REMARK 465     GLY C   299
REMARK 465     LEU C   300
REMARK 465     ARG C   301
REMARK 465     GLU C   302
REMARK 465     GLU C   303
REMARK 465     GLU C   304
REMARK 465     PHE C   305
REMARK 465     ALA C   306
REMARK 465     VAL C   307
REMARK 465     GLU C   308
REMARK 465     LYS C   309
REMARK 465     GLY C   310
REMARK 465     VAL C   311
REMARK 465     LYS C   312
REMARK 465     GLU C   313
REMARK 465     ILE C   314
REMARK 465     THR C   315
REMARK 465     VAL C   316
REMARK 465     HIS C   317
REMARK 465     TRP C   318
REMARK 465     LEU C   319
REMARK 465     SER C   320
REMARK 465     ASN C   321
REMARK 465     HIS C   322
REMARK 465     SER C   323
REMARK 465     SER C   324
REMARK 465     GLY C   325
REMARK 465     ASN C   326
REMARK 465     ILE C   327
REMARK 465     LYS C   328
REMARK 465     LEU C   329
REMARK 465     THR C   330
REMARK 465     ASP C   331
REMARK 465     PRO C   332
REMARK 465     ARG C   333
REMARK 465     GLY C   334
REMARK 465     LYS C   335
REMARK 465     PRO C   336
REMARK 465     PHE C   337
REMARK 465     LYS C   338
REMARK 465     ASP C   339
REMARK 465     PHE C   340
REMARK 465     SER C   341
REMARK 465     ILE C   342
REMARK 465     ALA C   343
REMARK 465     LYS C   344
REMARK 465     THR C   345
REMARK 465     ALA C   346
REMARK 465     ASP C   347
REMARK 465     VAL C   348
REMARK 465     PHE C   349
REMARK 465     GLU C   350
REMARK 465     GLY C   351
REMARK 465     GLY C   352
REMARK 465     PHE C   353
REMARK 465     VAL C   354
REMARK 465     HIS C   355
REMARK 465     SER C   356
REMARK 465     ALA C   357
REMARK 465     ALA C   358
REMARK 465     ILE C   359
REMARK 465     LYS C   360
REMARK 465     ASN C   361
REMARK 465     PRO C   362
REMARK 465     ALA C   363
REMARK 465     ALA C   364
REMARK 465     GLY C   365
REMARK 465     THR C   366
REMARK 465     TRP C   367
REMARK 465     LYS C   368
REMARK 465     ILE C   369
REMARK 465     ALA C   370
REMARK 465     SER C   371
REMARK 465     SER C   372
REMARK 465     VAL C   373
REMARK 465     LYS C   374
REMARK 465     GLN C   375
REMARK 465     LYS C   376
REMARK 465     GLU C   377
REMARK 465     ALA C   378
REMARK 465     PHE C   379
REMARK 465     LEU C   380
REMARK 465     PHE C   381
REMARK 465     ILE C   382
REMARK 465     VAL C   383
REMARK 465     THR C   384
REMARK 465     PHE C   385
REMARK 465     ASP C   386
REMARK 465     SER C   387
REMARK 465     PRO C   388
REMARK 465     LEU C   389
REMARK 465     ASN C   390
REMARK 465     GLN C   391
REMARK 465     GLN C   392
REMARK 465     ILE C   393
REMARK 465     LYS C   394
REMARK 465     ASN C   395
REMARK 465     ALA C   396
REMARK 465     VAL C   397
REMARK 465     THR C   398
REMARK 465     ARG C   399
REMARK 465     GLU C   400
REMARK 465     SER C   401
REMARK 465     SER C   402
REMARK 465     ASN C   403
REMARK 465     LEU C   404
REMARK 465     ALA C   405
REMARK 465     ASN C   406
REMARK 465     VAL C   407
REMARK 465     LYS C   408
REMARK 465     ALA C   409
REMARK 465     SER C   410
REMARK 465     VAL C   411
REMARK 465     ARG C   412
REMARK 465     SER C   413
REMARK 465     ILE C   414
REMARK 465     ARG C   415
REMARK 465     TYR C   416
REMARK 465     GLU C   417
REMARK 465     ASN C   418
REMARK 465     GLY C   419
REMARK 465     LYS C   420
REMARK 465     GLN C   421
REMARK 465     ALA C   422
REMARK 465     GLU C   423
REMARK 465     LYS C   424
REMARK 465     LYS C   425
REMARK 465     SER C   426
REMARK 465     LEU C   427
REMARK 465     LYS C   428
REMARK 465     PRO C   429
REMARK 465     ALA C   430
REMARK 465     SER C   431
REMARK 465     ILE C   432
REMARK 465     ASN C   433
REMARK 465     ALA C   434
REMARK 465     LEU C   435
REMARK 465     GLN C   436
REMARK 465     ASN C   437
REMARK 465     SER C   438
REMARK 465     LEU C   439
REMARK 465     SER C   440
REMARK 465     PHE C   441
REMARK 465     LYS C   442
REMARK 465     LYS C   443
REMARK 465     ALA C   444
REMARK 465     GLY C   445
REMARK 465     MET C   446
REMARK 465     TYR C   447
REMARK 465     SER C   448
REMARK 465     VAL C   449
REMARK 465     THR C   450
REMARK 465     ILE C   451
REMARK 465     ASP C   452
REMARK 465     LEU C   453
REMARK 465     SER C   454
REMARK 465     GLY C   455
REMARK 465     LYS C   456
REMARK 465     THR C   457
REMARK 465     ALA C   458
REMARK 465     ASP C   459
REMARK 465     ASN C   460
REMARK 465     SER C   461
REMARK 465     PRO C   462
REMARK 465     PHE C   463
REMARK 465     ASN C   464
REMARK 465     ARG C   465
REMARK 465     THR C   466
REMARK 465     ILE C   467
REMARK 465     ILE C   468
REMARK 465     ARG C   469
REMARK 465     SER C   470
REMARK 465     ILE C   471
REMARK 465     TYR C   472
REMARK 465     VAL C   473
REMARK 465     ASN C   474
REMARK 465     ASP C   475
REMARK 465     LYS C   476
REMARK 465     GLY C   477
REMARK 465     GLU C   478
REMARK 465     LYS C   479
REMARK 465     PHE C   480
REMARK 465     GLU C   481
REMARK 465     ASN C   482
REMARK 465     SER C   483
REMARK 465     PRO C   484
REMARK 465     LEU C   485
REMARK 465     SER C   486
REMARK 465     ASP C   487
REMARK 465     MET D     1
REMARK 465     LYS D     2
REMARK 465     LYS D     3
REMARK 465     LEU D     4
REMARK 465     VAL D     5
REMARK 465     LEU D     6
REMARK 465     LEU D     7
REMARK 465     MET D     8
REMARK 465     LEU D     9
REMARK 465     VAL D    10
REMARK 465     LEU D    11
REMARK 465     LEU D    12
REMARK 465     LEU D    13
REMARK 465     VAL D    14
REMARK 465     TYR D    15
REMARK 465     PRO D    16
REMARK 465     HIS D    17
REMARK 465     VAL D    18
REMARK 465     SER D    19
REMARK 465     LYS D    20
REMARK 465     ALA D    21
REMARK 465     GLY D    22
REMARK 465     GLY D    23
REMARK 465     PHE D    24
REMARK 465     LYS D    25
REMARK 465     GLY D    26
REMARK 465     GLY D    27
REMARK 465     GLY D    28
REMARK 465     GLN D   274
REMARK 465     ALA D   275
REMARK 465     ASN D   276
REMARK 465     ALA D   277
REMARK 465     ASN D   278
REMARK 465     GLU D   279
REMARK 465     THR D   280
REMARK 465     ALA D   281
REMARK 465     ALA D   282
REMARK 465     THR D   283
REMARK 465     LYS D   284
REMARK 465     GLU D   285
REMARK 465     ASN D   286
REMARK 465     LEU D   287
REMARK 465     SER D   288
REMARK 465     TYR D   289
REMARK 465     PRO D   290
REMARK 465     PHE D   291
REMARK 465     ILE D   292
REMARK 465     ARG D   293
REMARK 465     GLY D   294
REMARK 465     GLY D   295
REMARK 465     GLU D   296
REMARK 465     ASN D   297
REMARK 465     HIS D   298
REMARK 465     GLY D   299
REMARK 465     LEU D   300
REMARK 465     ARG D   301
REMARK 465     GLU D   302
REMARK 465     GLU D   303
REMARK 465     GLU D   304
REMARK 465     PHE D   305
REMARK 465     ALA D   306
REMARK 465     VAL D   307
REMARK 465     GLU D   308
REMARK 465     LYS D   309
REMARK 465     GLY D   310
REMARK 465     VAL D   311
REMARK 465     LYS D   312
REMARK 465     GLU D   313
REMARK 465     ILE D   314
REMARK 465     THR D   315
REMARK 465     VAL D   316
REMARK 465     HIS D   317
REMARK 465     TRP D   318
REMARK 465     LEU D   319
REMARK 465     SER D   320
REMARK 465     ASN D   321
REMARK 465     HIS D   322
REMARK 465     SER D   323
REMARK 465     SER D   324
REMARK 465     GLY D   325
REMARK 465     ASN D   326
REMARK 465     ILE D   327
REMARK 465     LYS D   328
REMARK 465     LEU D   329
REMARK 465     THR D   330
REMARK 465     ASP D   331
REMARK 465     PRO D   332
REMARK 465     ARG D   333
REMARK 465     GLY D   334
REMARK 465     LYS D   335
REMARK 465     PRO D   336
REMARK 465     PHE D   337
REMARK 465     LYS D   338
REMARK 465     ASP D   339
REMARK 465     PHE D   340
REMARK 465     SER D   341
REMARK 465     ILE D   342
REMARK 465     ALA D   343
REMARK 465     LYS D   344
REMARK 465     THR D   345
REMARK 465     ALA D   346
REMARK 465     ASP D   347
REMARK 465     VAL D   348
REMARK 465     PHE D   349
REMARK 465     GLU D   350
REMARK 465     GLY D   351
REMARK 465     GLY D   352
REMARK 465     PHE D   353
REMARK 465     VAL D   354
REMARK 465     HIS D   355
REMARK 465     SER D   356
REMARK 465     ALA D   357
REMARK 465     ALA D   358
REMARK 465     ILE D   359
REMARK 465     LYS D   360
REMARK 465     ASN D   361
REMARK 465     PRO D   362
REMARK 465     ALA D   363
REMARK 465     ALA D   364
REMARK 465     GLY D   365
REMARK 465     THR D   366
REMARK 465     TRP D   367
REMARK 465     LYS D   368
REMARK 465     ILE D   369
REMARK 465     ALA D   370
REMARK 465     SER D   371
REMARK 465     SER D   372
REMARK 465     VAL D   373
REMARK 465     LYS D   374
REMARK 465     GLN D   375
REMARK 465     LYS D   376
REMARK 465     GLU D   377
REMARK 465     ALA D   378
REMARK 465     PHE D   379
REMARK 465     LEU D   380
REMARK 465     PHE D   381
REMARK 465     ILE D   382
REMARK 465     VAL D   383
REMARK 465     THR D   384
REMARK 465     PHE D   385
REMARK 465     ASP D   386
REMARK 465     SER D   387
REMARK 465     PRO D   388
REMARK 465     LEU D   389
REMARK 465     ASN D   390
REMARK 465     GLN D   391
REMARK 465     GLN D   392
REMARK 465     ILE D   393
REMARK 465     LYS D   394
REMARK 465     ASN D   395
REMARK 465     ALA D   396
REMARK 465     VAL D   397
REMARK 465     THR D   398
REMARK 465     ARG D   399
REMARK 465     GLU D   400
REMARK 465     SER D   401
REMARK 465     SER D   402
REMARK 465     ASN D   403
REMARK 465     LEU D   404
REMARK 465     ALA D   405
REMARK 465     ASN D   406
REMARK 465     VAL D   407
REMARK 465     LYS D   408
REMARK 465     ALA D   409
REMARK 465     SER D   410
REMARK 465     VAL D   411
REMARK 465     ARG D   412
REMARK 465     SER D   413
REMARK 465     ILE D   414
REMARK 465     ARG D   415
REMARK 465     TYR D   416
REMARK 465     GLU D   417
REMARK 465     ASN D   418
REMARK 465     GLY D   419
REMARK 465     LYS D   420
REMARK 465     GLN D   421
REMARK 465     ALA D   422
REMARK 465     GLU D   423
REMARK 465     LYS D   424
REMARK 465     LYS D   425
REMARK 465     SER D   426
REMARK 465     LEU D   427
REMARK 465     LYS D   428
REMARK 465     PRO D   429
REMARK 465     ALA D   430
REMARK 465     SER D   431
REMARK 465     ILE D   432
REMARK 465     ASN D   433
REMARK 465     ALA D   434
REMARK 465     LEU D   435
REMARK 465     GLN D   436
REMARK 465     ASN D   437
REMARK 465     SER D   438
REMARK 465     LEU D   439
REMARK 465     SER D   440
REMARK 465     PHE D   441
REMARK 465     LYS D   442
REMARK 465     LYS D   443
REMARK 465     ALA D   444
REMARK 465     GLY D   445
REMARK 465     MET D   446
REMARK 465     TYR D   447
REMARK 465     SER D   448
REMARK 465     VAL D   449
REMARK 465     THR D   450
REMARK 465     ILE D   451
REMARK 465     ASP D   452
REMARK 465     LEU D   453
REMARK 465     SER D   454
REMARK 465     GLY D   455
REMARK 465     LYS D   456
REMARK 465     THR D   457
REMARK 465     ALA D   458
REMARK 465     ASP D   459
REMARK 465     ASN D   460
REMARK 465     SER D   461
REMARK 465     PRO D   462
REMARK 465     PHE D   463
REMARK 465     ASN D   464
REMARK 465     ARG D   465
REMARK 465     THR D   466
REMARK 465     ILE D   467
REMARK 465     ILE D   468
REMARK 465     ARG D   469
REMARK 465     SER D   470
REMARK 465     ILE D   471
REMARK 465     TYR D   472
REMARK 465     VAL D   473
REMARK 465     ASN D   474
REMARK 465     ASP D   475
REMARK 465     LYS D   476
REMARK 465     GLY D   477
REMARK 465     GLU D   478
REMARK 465     LYS D   479
REMARK 465     PHE D   480
REMARK 465     GLU D   481
REMARK 465     ASN D   482
REMARK 465     SER D   483
REMARK 465     PRO D   484
REMARK 465     LEU D   485
REMARK 465     SER D   486
REMARK 465     ASP D   487
REMARK 465     MET E     1
REMARK 465     LYS E     2
REMARK 465     LYS E     3
REMARK 465     LEU E     4
REMARK 465     VAL E     5
REMARK 465     LEU E     6
REMARK 465     LEU E     7
REMARK 465     MET E     8
REMARK 465     LEU E     9
REMARK 465     VAL E    10
REMARK 465     LEU E    11
REMARK 465     LEU E    12
REMARK 465     LEU E    13
REMARK 465     VAL E    14
REMARK 465     TYR E    15
REMARK 465     PRO E    16
REMARK 465     HIS E    17
REMARK 465     VAL E    18
REMARK 465     SER E    19
REMARK 465     LYS E    20
REMARK 465     ALA E    21
REMARK 465     GLY E    22
REMARK 465     GLY E    23
REMARK 465     PHE E    24
REMARK 465     LYS E    25
REMARK 465     GLY E    26
REMARK 465     GLY E    27
REMARK 465     GLY E    28
REMARK 465     GLN E   274
REMARK 465     ALA E   275
REMARK 465     ASN E   276
REMARK 465     ALA E   277
REMARK 465     ASN E   278
REMARK 465     GLU E   279
REMARK 465     THR E   280
REMARK 465     ALA E   281
REMARK 465     ALA E   282
REMARK 465     THR E   283
REMARK 465     LYS E   284
REMARK 465     GLU E   285
REMARK 465     ASN E   286
REMARK 465     LEU E   287
REMARK 465     SER E   288
REMARK 465     TYR E   289
REMARK 465     PRO E   290
REMARK 465     PHE E   291
REMARK 465     ILE E   292
REMARK 465     ARG E   293
REMARK 465     GLY E   294
REMARK 465     GLY E   295
REMARK 465     GLU E   296
REMARK 465     ASN E   297
REMARK 465     HIS E   298
REMARK 465     GLY E   299
REMARK 465     LEU E   300
REMARK 465     ARG E   301
REMARK 465     GLU E   302
REMARK 465     GLU E   303
REMARK 465     GLU E   304
REMARK 465     PHE E   305
REMARK 465     ALA E   306
REMARK 465     VAL E   307
REMARK 465     GLU E   308
REMARK 465     LYS E   309
REMARK 465     GLY E   310
REMARK 465     VAL E   311
REMARK 465     LYS E   312
REMARK 465     GLU E   313
REMARK 465     ILE E   314
REMARK 465     THR E   315
REMARK 465     VAL E   316
REMARK 465     HIS E   317
REMARK 465     TRP E   318
REMARK 465     LEU E   319
REMARK 465     SER E   320
REMARK 465     ASN E   321
REMARK 465     HIS E   322
REMARK 465     SER E   323
REMARK 465     SER E   324
REMARK 465     GLY E   325
REMARK 465     ASN E   326
REMARK 465     ILE E   327
REMARK 465     LYS E   328
REMARK 465     LEU E   329
REMARK 465     THR E   330
REMARK 465     ASP E   331
REMARK 465     PRO E   332
REMARK 465     ARG E   333
REMARK 465     GLY E   334
REMARK 465     LYS E   335
REMARK 465     PRO E   336
REMARK 465     PHE E   337
REMARK 465     LYS E   338
REMARK 465     ASP E   339
REMARK 465     PHE E   340
REMARK 465     SER E   341
REMARK 465     ILE E   342
REMARK 465     ALA E   343
REMARK 465     LYS E   344
REMARK 465     THR E   345
REMARK 465     ALA E   346
REMARK 465     ASP E   347
REMARK 465     VAL E   348
REMARK 465     PHE E   349
REMARK 465     GLU E   350
REMARK 465     GLY E   351
REMARK 465     GLY E   352
REMARK 465     PHE E   353
REMARK 465     VAL E   354
REMARK 465     HIS E   355
REMARK 465     SER E   356
REMARK 465     ALA E   357
REMARK 465     ALA E   358
REMARK 465     ILE E   359
REMARK 465     LYS E   360
REMARK 465     ASN E   361
REMARK 465     PRO E   362
REMARK 465     ALA E   363
REMARK 465     ALA E   364
REMARK 465     GLY E   365
REMARK 465     THR E   366
REMARK 465     TRP E   367
REMARK 465     LYS E   368
REMARK 465     ILE E   369
REMARK 465     ALA E   370
REMARK 465     SER E   371
REMARK 465     SER E   372
REMARK 465     VAL E   373
REMARK 465     LYS E   374
REMARK 465     GLN E   375
REMARK 465     LYS E   376
REMARK 465     GLU E   377
REMARK 465     ALA E   378
REMARK 465     PHE E   379
REMARK 465     LEU E   380
REMARK 465     PHE E   381
REMARK 465     ILE E   382
REMARK 465     VAL E   383
REMARK 465     THR E   384
REMARK 465     PHE E   385
REMARK 465     ASP E   386
REMARK 465     SER E   387
REMARK 465     PRO E   388
REMARK 465     LEU E   389
REMARK 465     ASN E   390
REMARK 465     GLN E   391
REMARK 465     GLN E   392
REMARK 465     ILE E   393
REMARK 465     LYS E   394
REMARK 465     ASN E   395
REMARK 465     ALA E   396
REMARK 465     VAL E   397
REMARK 465     THR E   398
REMARK 465     ARG E   399
REMARK 465     GLU E   400
REMARK 465     SER E   401
REMARK 465     SER E   402
REMARK 465     ASN E   403
REMARK 465     LEU E   404
REMARK 465     ALA E   405
REMARK 465     ASN E   406
REMARK 465     VAL E   407
REMARK 465     LYS E   408
REMARK 465     ALA E   409
REMARK 465     SER E   410
REMARK 465     VAL E   411
REMARK 465     ARG E   412
REMARK 465     SER E   413
REMARK 465     ILE E   414
REMARK 465     ARG E   415
REMARK 465     TYR E   416
REMARK 465     GLU E   417
REMARK 465     ASN E   418
REMARK 465     GLY E   419
REMARK 465     LYS E   420
REMARK 465     GLN E   421
REMARK 465     ALA E   422
REMARK 465     GLU E   423
REMARK 465     LYS E   424
REMARK 465     LYS E   425
REMARK 465     SER E   426
REMARK 465     LEU E   427
REMARK 465     LYS E   428
REMARK 465     PRO E   429
REMARK 465     ALA E   430
REMARK 465     SER E   431
REMARK 465     ILE E   432
REMARK 465     ASN E   433
REMARK 465     ALA E   434
REMARK 465     LEU E   435
REMARK 465     GLN E   436
REMARK 465     ASN E   437
REMARK 465     SER E   438
REMARK 465     LEU E   439
REMARK 465     SER E   440
REMARK 465     PHE E   441
REMARK 465     LYS E   442
REMARK 465     LYS E   443
REMARK 465     ALA E   444
REMARK 465     GLY E   445
REMARK 465     MET E   446
REMARK 465     TYR E   447
REMARK 465     SER E   448
REMARK 465     VAL E   449
REMARK 465     THR E   450
REMARK 465     ILE E   451
REMARK 465     ASP E   452
REMARK 465     LEU E   453
REMARK 465     SER E   454
REMARK 465     GLY E   455
REMARK 465     LYS E   456
REMARK 465     THR E   457
REMARK 465     ALA E   458
REMARK 465     ASP E   459
REMARK 465     ASN E   460
REMARK 465     SER E   461
REMARK 465     PRO E   462
REMARK 465     PHE E   463
REMARK 465     ASN E   464
REMARK 465     ARG E   465
REMARK 465     THR E   466
REMARK 465     ILE E   467
REMARK 465     ILE E   468
REMARK 465     ARG E   469
REMARK 465     SER E   470
REMARK 465     ILE E   471
REMARK 465     TYR E   472
REMARK 465     VAL E   473
REMARK 465     ASN E   474
REMARK 465     ASP E   475
REMARK 465     LYS E   476
REMARK 465     GLY E   477
REMARK 465     GLU E   478
REMARK 465     LYS E   479
REMARK 465     PHE E   480
REMARK 465     GLU E   481
REMARK 465     ASN E   482
REMARK 465     SER E   483
REMARK 465     PRO E   484
REMARK 465     LEU E   485
REMARK 465     SER E   486
REMARK 465     ASP E   487
REMARK 465     MET F     1
REMARK 465     LYS F     2
REMARK 465     LYS F     3
REMARK 465     LEU F     4
REMARK 465     VAL F     5
REMARK 465     LEU F     6
REMARK 465     LEU F     7
REMARK 465     MET F     8
REMARK 465     LEU F     9
REMARK 465     VAL F    10
REMARK 465     LEU F    11
REMARK 465     LEU F    12
REMARK 465     LEU F    13
REMARK 465     VAL F    14
REMARK 465     TYR F    15
REMARK 465     PRO F    16
REMARK 465     HIS F    17
REMARK 465     VAL F    18
REMARK 465     SER F    19
REMARK 465     LYS F    20
REMARK 465     ALA F    21
REMARK 465     GLY F    22
REMARK 465     GLY F    23
REMARK 465     PHE F    24
REMARK 465     LYS F    25
REMARK 465     GLY F    26
REMARK 465     GLY F    27
REMARK 465     GLY F    28
REMARK 465     GLN F   274
REMARK 465     ALA F   275
REMARK 465     ASN F   276
REMARK 465     ALA F   277
REMARK 465     ASN F   278
REMARK 465     GLU F   279
REMARK 465     THR F   280
REMARK 465     ALA F   281
REMARK 465     ALA F   282
REMARK 465     THR F   283
REMARK 465     LYS F   284
REMARK 465     GLU F   285
REMARK 465     ASN F   286
REMARK 465     LEU F   287
REMARK 465     SER F   288
REMARK 465     TYR F   289
REMARK 465     PRO F   290
REMARK 465     PHE F   291
REMARK 465     ILE F   292
REMARK 465     ARG F   293
REMARK 465     GLY F   294
REMARK 465     GLY F   295
REMARK 465     GLU F   296
REMARK 465     ASN F   297
REMARK 465     HIS F   298
REMARK 465     GLY F   299
REMARK 465     LEU F   300
REMARK 465     ARG F   301
REMARK 465     GLU F   302
REMARK 465     GLU F   303
REMARK 465     GLU F   304
REMARK 465     PHE F   305
REMARK 465     ALA F   306
REMARK 465     VAL F   307
REMARK 465     GLU F   308
REMARK 465     LYS F   309
REMARK 465     GLY F   310
REMARK 465     VAL F   311
REMARK 465     LYS F   312
REMARK 465     GLU F   313
REMARK 465     ILE F   314
REMARK 465     THR F   315
REMARK 465     VAL F   316
REMARK 465     HIS F   317
REMARK 465     TRP F   318
REMARK 465     LEU F   319
REMARK 465     SER F   320
REMARK 465     ASN F   321
REMARK 465     HIS F   322
REMARK 465     SER F   323
REMARK 465     SER F   324
REMARK 465     GLY F   325
REMARK 465     ASN F   326
REMARK 465     ILE F   327
REMARK 465     LYS F   328
REMARK 465     LEU F   329
REMARK 465     THR F   330
REMARK 465     ASP F   331
REMARK 465     PRO F   332
REMARK 465     ARG F   333
REMARK 465     GLY F   334
REMARK 465     LYS F   335
REMARK 465     PRO F   336
REMARK 465     PHE F   337
REMARK 465     LYS F   338
REMARK 465     ASP F   339
REMARK 465     PHE F   340
REMARK 465     SER F   341
REMARK 465     ILE F   342
REMARK 465     ALA F   343
REMARK 465     LYS F   344
REMARK 465     THR F   345
REMARK 465     ALA F   346
REMARK 465     ASP F   347
REMARK 465     VAL F   348
REMARK 465     PHE F   349
REMARK 465     GLU F   350
REMARK 465     GLY F   351
REMARK 465     GLY F   352
REMARK 465     PHE F   353
REMARK 465     VAL F   354
REMARK 465     HIS F   355
REMARK 465     SER F   356
REMARK 465     ALA F   357
REMARK 465     ALA F   358
REMARK 465     ILE F   359
REMARK 465     LYS F   360
REMARK 465     ASN F   361
REMARK 465     PRO F   362
REMARK 465     ALA F   363
REMARK 465     ALA F   364
REMARK 465     GLY F   365
REMARK 465     THR F   366
REMARK 465     TRP F   367
REMARK 465     LYS F   368
REMARK 465     ILE F   369
REMARK 465     ALA F   370
REMARK 465     SER F   371
REMARK 465     SER F   372
REMARK 465     VAL F   373
REMARK 465     LYS F   374
REMARK 465     GLN F   375
REMARK 465     LYS F   376
REMARK 465     GLU F   377
REMARK 465     ALA F   378
REMARK 465     PHE F   379
REMARK 465     LEU F   380
REMARK 465     PHE F   381
REMARK 465     ILE F   382
REMARK 465     VAL F   383
REMARK 465     THR F   384
REMARK 465     PHE F   385
REMARK 465     ASP F   386
REMARK 465     SER F   387
REMARK 465     PRO F   388
REMARK 465     LEU F   389
REMARK 465     ASN F   390
REMARK 465     GLN F   391
REMARK 465     GLN F   392
REMARK 465     ILE F   393
REMARK 465     LYS F   394
REMARK 465     ASN F   395
REMARK 465     ALA F   396
REMARK 465     VAL F   397
REMARK 465     THR F   398
REMARK 465     ARG F   399
REMARK 465     GLU F   400
REMARK 465     SER F   401
REMARK 465     SER F   402
REMARK 465     ASN F   403
REMARK 465     LEU F   404
REMARK 465     ALA F   405
REMARK 465     ASN F   406
REMARK 465     VAL F   407
REMARK 465     LYS F   408
REMARK 465     ALA F   409
REMARK 465     SER F   410
REMARK 465     VAL F   411
REMARK 465     ARG F   412
REMARK 465     SER F   413
REMARK 465     ILE F   414
REMARK 465     ARG F   415
REMARK 465     TYR F   416
REMARK 465     GLU F   417
REMARK 465     ASN F   418
REMARK 465     GLY F   419
REMARK 465     LYS F   420
REMARK 465     GLN F   421
REMARK 465     ALA F   422
REMARK 465     GLU F   423
REMARK 465     LYS F   424
REMARK 465     LYS F   425
REMARK 465     SER F   426
REMARK 465     LEU F   427
REMARK 465     LYS F   428
REMARK 465     PRO F   429
REMARK 465     ALA F   430
REMARK 465     SER F   431
REMARK 465     ILE F   432
REMARK 465     ASN F   433
REMARK 465     ALA F   434
REMARK 465     LEU F   435
REMARK 465     GLN F   436
REMARK 465     ASN F   437
REMARK 465     SER F   438
REMARK 465     LEU F   439
REMARK 465     SER F   440
REMARK 465     PHE F   441
REMARK 465     LYS F   442
REMARK 465     LYS F   443
REMARK 465     ALA F   444
REMARK 465     GLY F   445
REMARK 465     MET F   446
REMARK 465     TYR F   447
REMARK 465     SER F   448
REMARK 465     VAL F   449
REMARK 465     THR F   450
REMARK 465     ILE F   451
REMARK 465     ASP F   452
REMARK 465     LEU F   453
REMARK 465     SER F   454
REMARK 465     GLY F   455
REMARK 465     LYS F   456
REMARK 465     THR F   457
REMARK 465     ALA F   458
REMARK 465     ASP F   459
REMARK 465     ASN F   460
REMARK 465     SER F   461
REMARK 465     PRO F   462
REMARK 465     PHE F   463
REMARK 465     ASN F   464
REMARK 465     ARG F   465
REMARK 465     THR F   466
REMARK 465     ILE F   467
REMARK 465     ILE F   468
REMARK 465     ARG F   469
REMARK 465     SER F   470
REMARK 465     ILE F   471
REMARK 465     TYR F   472
REMARK 465     VAL F   473
REMARK 465     ASN F   474
REMARK 465     ASP F   475
REMARK 465     LYS F   476
REMARK 465     GLY F   477
REMARK 465     GLU F   478
REMARK 465     LYS F   479
REMARK 465     PHE F   480
REMARK 465     GLU F   481
REMARK 465     ASN F   482
REMARK 465     SER F   483
REMARK 465     PRO F   484
REMARK 465     LEU F   485
REMARK 465     SER F   486
REMARK 465     ASP F   487
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    SER A 119     -129.37     50.69
REMARK 500    ALA A 233      -34.00   -136.92
REMARK 500    SER B 119     -126.62     52.67
REMARK 500    ALA B 233      -36.26   -130.32
REMARK 500    ASP C  38      133.75    -38.08
REMARK 500    SER C 119     -121.76     39.04
REMARK 500    ASN C 160       65.36   -160.21
REMARK 500    ALA C 233      -31.55   -145.81
REMARK 500    THR C 249       87.52    -48.61
REMARK 500    ASN D  57       27.36     43.00
REMARK 500    ASP D  90     -179.34    -65.71
REMARK 500    SER D 119     -130.52     42.72
REMARK 500    LEU D 156       21.21    -71.70
REMARK 500    ASN D 160       89.91   -163.99
REMARK 500    TRP D 161     -145.42    -52.87
REMARK 500    ALA D 162      153.94    145.07
REMARK 500    ALA D 233      -36.80   -140.55
REMARK 500    ASP E  90     -179.58    -59.92
REMARK 500    SER E 119     -127.65     44.17
REMARK 500    LYS E 172      128.65    -38.68
REMARK 500    ALA E 233      -38.10   -141.69
REMARK 500    ASP E 248      126.59    -35.40
REMARK 500    PHE F  64      -71.10   -119.13
REMARK 500    SER F 119     -123.48     46.29
REMARK 500    SER F 159      -65.90   -171.70
REMARK 500    LYS F 172      128.09    -38.72
REMARK 500    ALA F 233      -43.29   -143.00
REMARK 500    ASN F 261      -50.77    -27.46
REMARK 500
REMARK 500 REMARK: NULL
REMARK 525
REMARK 525 SOLVENT
REMARK 525
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 525 NUMBER; I=INSERTION CODE):
REMARK 525
REMARK 525  M RES CSSEQI
REMARK 525    HOH A 541        DISTANCE =  6.46 ANGSTROMS
REMARK 525    HOH A 542        DISTANCE =  6.60 ANGSTROMS
REMARK 525    HOH A 543        DISTANCE =  6.63 ANGSTROMS
REMARK 525    HOH A 544        DISTANCE =  7.32 ANGSTROMS
REMARK 525    HOH A 545        DISTANCE =  7.47 ANGSTROMS
REMARK 525    HOH A 546        DISTANCE =  7.66 ANGSTROMS
REMARK 525    HOH A 547        DISTANCE =  8.34 ANGSTROMS
REMARK 525    HOH A 548        DISTANCE =  8.48 ANGSTROMS
REMARK 525    HOH A 549        DISTANCE =  8.48 ANGSTROMS
REMARK 525    HOH A 550        DISTANCE =  8.61 ANGSTROMS
REMARK 525    HOH A 551        DISTANCE =  8.94 ANGSTROMS
REMARK 525    HOH A 552        DISTANCE = 10.10 ANGSTROMS
REMARK 525    HOH A 553        DISTANCE = 10.24 ANGSTROMS
REMARK 525    HOH A 554        DISTANCE = 11.02 ANGSTROMS
REMARK 525    HOH A 555        DISTANCE = 12.30 ANGSTROMS
REMARK 525    HOH A 556        DISTANCE = 12.81 ANGSTROMS
REMARK 525    HOH A 557        DISTANCE = 14.56 ANGSTROMS
REMARK 525    HOH A 558        DISTANCE = 15.58 ANGSTROMS
REMARK 525    HOH A 559        DISTANCE = 15.75 ANGSTROMS
REMARK 525    HOH B 545        DISTANCE =  6.17 ANGSTROMS
REMARK 525    HOH B 546        DISTANCE =  6.43 ANGSTROMS
REMARK 525    HOH B 547        DISTANCE =  6.66 ANGSTROMS
REMARK 525    HOH B 548        DISTANCE =  6.85 ANGSTROMS
REMARK 525    HOH B 549        DISTANCE =  7.83 ANGSTROMS
REMARK 525    HOH B 550        DISTANCE =  8.13 ANGSTROMS
REMARK 525    HOH B 551        DISTANCE =  9.12 ANGSTROMS
REMARK 525    HOH B 552        DISTANCE = 11.54 ANGSTROMS
REMARK 525    HOH B 553        DISTANCE = 12.75 ANGSTROMS
REMARK 525    HOH B 554        DISTANCE = 13.71 ANGSTROMS
REMARK 525    HOH C 535        DISTANCE =  5.99 ANGSTROMS
REMARK 525    HOH C 536        DISTANCE =  6.45 ANGSTROMS
REMARK 525    HOH C 537        DISTANCE =  7.04 ANGSTROMS
REMARK 525    HOH C 538        DISTANCE =  7.19 ANGSTROMS
REMARK 525    HOH C 539        DISTANCE =  7.37 ANGSTROMS
REMARK 525    HOH C 540        DISTANCE =  7.40 ANGSTROMS
REMARK 525    HOH C 541        DISTANCE =  7.60 ANGSTROMS
REMARK 525    HOH C 542        DISTANCE =  7.79 ANGSTROMS
REMARK 525    HOH C 543        DISTANCE =  8.17 ANGSTROMS
REMARK 525    HOH C 544        DISTANCE = 10.90 ANGSTROMS
REMARK 525    HOH D 530        DISTANCE =  6.32 ANGSTROMS
REMARK 525    HOH D 531        DISTANCE =  6.36 ANGSTROMS
REMARK 525    HOH D 532        DISTANCE =  6.37 ANGSTROMS
REMARK 525    HOH D 533        DISTANCE =  6.41 ANGSTROMS
REMARK 525    HOH D 534        DISTANCE =  6.61 ANGSTROMS
REMARK 525    HOH D 535        DISTANCE =  6.96 ANGSTROMS
REMARK 525    HOH D 536        DISTANCE =  8.37 ANGSTROMS
REMARK 525    HOH D 537        DISTANCE =  8.96 ANGSTROMS
REMARK 525    HOH D 538        DISTANCE =  9.51 ANGSTROMS
REMARK 525    HOH D 539        DISTANCE = 10.30 ANGSTROMS
REMARK 525    HOH D 540        DISTANCE = 10.43 ANGSTROMS
REMARK 525    HOH D 541        DISTANCE = 11.68 ANGSTROMS
REMARK 525    HOH D 542        DISTANCE = 11.79 ANGSTROMS
REMARK 525    HOH D 543        DISTANCE = 14.71 ANGSTROMS
REMARK 525    HOH D 544        DISTANCE = 15.82 ANGSTROMS
REMARK 525    HOH D 545        DISTANCE = 17.27 ANGSTROMS
REMARK 525    HOH E 529        DISTANCE =  6.64 ANGSTROMS
REMARK 525    HOH E 530        DISTANCE =  6.97 ANGSTROMS
REMARK 525    HOH E 531        DISTANCE =  7.26 ANGSTROMS
REMARK 525    HOH E 532        DISTANCE =  7.51 ANGSTROMS
REMARK 525    HOH E 533        DISTANCE =  8.08 ANGSTROMS
REMARK 525    HOH E 534        DISTANCE =  8.13 ANGSTROMS
REMARK 525    HOH E 535        DISTANCE =  8.50 ANGSTROMS
REMARK 525    HOH E 536        DISTANCE =  8.87 ANGSTROMS
REMARK 525    HOH E 537        DISTANCE =  9.12 ANGSTROMS
REMARK 525    HOH E 538        DISTANCE = 10.20 ANGSTROMS
REMARK 525    HOH E 539        DISTANCE = 11.82 ANGSTROMS
REMARK 525    HOH E 540        DISTANCE = 12.40 ANGSTROMS
REMARK 525    HOH F 523        DISTANCE =  5.81 ANGSTROMS
REMARK 525    HOH F 524        DISTANCE =  5.98 ANGSTROMS
REMARK 525    HOH F 525        DISTANCE =  6.19 ANGSTROMS
REMARK 525    HOH F 526        DISTANCE =  6.20 ANGSTROMS
REMARK 525    HOH F 527        DISTANCE =  6.58 ANGSTROMS
REMARK 525    HOH F 528        DISTANCE =  6.86 ANGSTROMS
REMARK 525    HOH F 529        DISTANCE =  7.12 ANGSTROMS
REMARK 525    HOH F 530        DISTANCE =  7.78 ANGSTROMS
REMARK 525    HOH F 531        DISTANCE =  8.51 ANGSTROMS
REMARK 525    HOH F 532        DISTANCE =  8.70 ANGSTROMS
REMARK 525    HOH F 533        DISTANCE =  9.40 ANGSTROMS
REMARK 525    HOH F 534        DISTANCE =  9.55 ANGSTROMS
REMARK 525    HOH F 535        DISTANCE = 11.92 ANGSTROMS
REMARK 525    HOH F 536        DISTANCE = 12.26 ANGSTROMS
REMARK 525    HOH F 537        DISTANCE = 17.96 ANGSTROMS
DBREF1 6WPY A    1   487  UNP                  A0A415J7C9_BACLI
DBREF2 6WPY A     A0A415J7C9                          1         487
DBREF1 6WPY B    1   487  UNP                  A0A415J7C9_BACLI
DBREF2 6WPY B     A0A415J7C9                          1         487
DBREF1 6WPY C    1   487  UNP                  A0A415J7C9_BACLI
DBREF2 6WPY C     A0A415J7C9                          1         487
DBREF1 6WPY D    1   487  UNP                  A0A415J7C9_BACLI
DBREF2 6WPY D     A0A415J7C9                          1         487
DBREF1 6WPY E    1   487  UNP                  A0A415J7C9_BACLI
DBREF2 6WPY E     A0A415J7C9                          1         487
DBREF1 6WPY F    1   487  UNP                  A0A415J7C9_BACLI
DBREF2 6WPY F     A0A415J7C9                          1         487
SEQRES   1 A  487  MET LYS LYS LEU VAL LEU LEU MET LEU VAL LEU LEU LEU
SEQRES   2 A  487  VAL TYR PRO HIS VAL SER LYS ALA GLY GLY PHE LYS GLY
SEQRES   3 A  487  GLY GLY GLY ASN PRO GLY TYR TRP PHE ALA GLY ASP PRO
SEQRES   4 A  487  VAL GLU HIS PRO ASP PRO ALA LYS PRO PRO ILE VAL PHE
SEQRES   5 A  487  VAL HIS GLY LEU ASN GLY SER SER SER ALA TRP PHE ASP
SEQRES   6 A  487  GLU ASN ASP MET ALA GLU GLN ALA TRP LYS ASN GLY TYR
SEQRES   7 A  487  ASP ALA ALA PHE ILE ASP LEU HIS PRO ASP LYS ASP MET
SEQRES   8 A  487  GLN ASP ASN GLY ALA MET LEU ALA ALA LYS LEU ARG GLU
SEQRES   9 A  487  ILE TYR GLN TYR PHE GLY ARG LYS VAL ILE LEU VAL SER
SEQRES  10 A  487  TYR SER LYS GLY GLY ILE ASP SER GLN SER ALA LEU ILE
SEQRES  11 A  487  HIS HIS ASN ALA TYR HIS TYR VAL GLU ARG VAL ILE THR
SEQRES  12 A  487  LEU GLY THR PRO HIS HIS GLY SER GLN LEU ALA ASP LEU
SEQRES  13 A  487  ALA TYR SER ASN TRP ALA GLY TRP LEU ALA ASP ILE LEU
SEQRES  14 A  487  GLY GLN LYS ASN ASP ALA VAL TYR SER LEU GLN THR GLY
SEQRES  15 A  487  PHE MET LYS SER PHE ARG ASP GLN THR ASP ASN HIS PRO
SEQRES  16 A  487  ASN ARG LEU LYS THR LYS TYR PHE THR LEU ALA GLY ASN
SEQRES  17 A  487  LYS ILE GLY GLY PHE GLY SER ALA LEU PHE PHE GLY GLY
SEQRES  18 A  487  VAL TYR LEU ASN MET PHE GLY GLU ASN ASP GLY ALA VAL
SEQRES  19 A  487  THR GLU LYS ASN ALA ARG LEU PRO TYR ALA THR ASN LEU
SEQRES  20 A  487  ASP THR GLY LYS TRP ASP HIS PHE SER ILE ILE LYS GLY
SEQRES  21 A  487  ASN LEU THR PHE PRO VAL PHE MET PRO LEU LEU THR ILE
SEQRES  22 A  487  GLN ALA ASN ALA ASN GLU THR ALA ALA THR LYS GLU ASN
SEQRES  23 A  487  LEU SER TYR PRO PHE ILE ARG GLY GLY GLU ASN HIS GLY
SEQRES  24 A  487  LEU ARG GLU GLU GLU PHE ALA VAL GLU LYS GLY VAL LYS
SEQRES  25 A  487  GLU ILE THR VAL HIS TRP LEU SER ASN HIS SER SER GLY
SEQRES  26 A  487  ASN ILE LYS LEU THR ASP PRO ARG GLY LYS PRO PHE LYS
SEQRES  27 A  487  ASP PHE SER ILE ALA LYS THR ALA ASP VAL PHE GLU GLY
SEQRES  28 A  487  GLY PHE VAL HIS SER ALA ALA ILE LYS ASN PRO ALA ALA
SEQRES  29 A  487  GLY THR TRP LYS ILE ALA SER SER VAL LYS GLN LYS GLU
SEQRES  30 A  487  ALA PHE LEU PHE ILE VAL THR PHE ASP SER PRO LEU ASN
SEQRES  31 A  487  GLN GLN ILE LYS ASN ALA VAL THR ARG GLU SER SER ASN
SEQRES  32 A  487  LEU ALA ASN VAL LYS ALA SER VAL ARG SER ILE ARG TYR
SEQRES  33 A  487  GLU ASN GLY LYS GLN ALA GLU LYS LYS SER LEU LYS PRO
SEQRES  34 A  487  ALA SER ILE ASN ALA LEU GLN ASN SER LEU SER PHE LYS
SEQRES  35 A  487  LYS ALA GLY MET TYR SER VAL THR ILE ASP LEU SER GLY
SEQRES  36 A  487  LYS THR ALA ASP ASN SER PRO PHE ASN ARG THR ILE ILE
SEQRES  37 A  487  ARG SER ILE TYR VAL ASN ASP LYS GLY GLU LYS PHE GLU
SEQRES  38 A  487  ASN SER PRO LEU SER ASP
SEQRES   1 B  487  MET LYS LYS LEU VAL LEU LEU MET LEU VAL LEU LEU LEU
SEQRES   2 B  487  VAL TYR PRO HIS VAL SER LYS ALA GLY GLY PHE LYS GLY
SEQRES   3 B  487  GLY GLY GLY ASN PRO GLY TYR TRP PHE ALA GLY ASP PRO
SEQRES   4 B  487  VAL GLU HIS PRO ASP PRO ALA LYS PRO PRO ILE VAL PHE
SEQRES   5 B  487  VAL HIS GLY LEU ASN GLY SER SER SER ALA TRP PHE ASP
SEQRES   6 B  487  GLU ASN ASP MET ALA GLU GLN ALA TRP LYS ASN GLY TYR
SEQRES   7 B  487  ASP ALA ALA PHE ILE ASP LEU HIS PRO ASP LYS ASP MET
SEQRES   8 B  487  GLN ASP ASN GLY ALA MET LEU ALA ALA LYS LEU ARG GLU
SEQRES   9 B  487  ILE TYR GLN TYR PHE GLY ARG LYS VAL ILE LEU VAL SER
SEQRES  10 B  487  TYR SER LYS GLY GLY ILE ASP SER GLN SER ALA LEU ILE
SEQRES  11 B  487  HIS HIS ASN ALA TYR HIS TYR VAL GLU ARG VAL ILE THR
SEQRES  12 B  487  LEU GLY THR PRO HIS HIS GLY SER GLN LEU ALA ASP LEU
SEQRES  13 B  487  ALA TYR SER ASN TRP ALA GLY TRP LEU ALA ASP ILE LEU
SEQRES  14 B  487  GLY GLN LYS ASN ASP ALA VAL TYR SER LEU GLN THR GLY
SEQRES  15 B  487  PHE MET LYS SER PHE ARG ASP GLN THR ASP ASN HIS PRO
SEQRES  16 B  487  ASN ARG LEU LYS THR LYS TYR PHE THR LEU ALA GLY ASN
SEQRES  17 B  487  LYS ILE GLY GLY PHE GLY SER ALA LEU PHE PHE GLY GLY
SEQRES  18 B  487  VAL TYR LEU ASN MET PHE GLY GLU ASN ASP GLY ALA VAL
SEQRES  19 B  487  THR GLU LYS ASN ALA ARG LEU PRO TYR ALA THR ASN LEU
SEQRES  20 B  487  ASP THR GLY LYS TRP ASP HIS PHE SER ILE ILE LYS GLY
SEQRES  21 B  487  ASN LEU THR PHE PRO VAL PHE MET PRO LEU LEU THR ILE
SEQRES  22 B  487  GLN ALA ASN ALA ASN GLU THR ALA ALA THR LYS GLU ASN
SEQRES  23 B  487  LEU SER TYR PRO PHE ILE ARG GLY GLY GLU ASN HIS GLY
SEQRES  24 B  487  LEU ARG GLU GLU GLU PHE ALA VAL GLU LYS GLY VAL LYS
SEQRES  25 B  487  GLU ILE THR VAL HIS TRP LEU SER ASN HIS SER SER GLY
SEQRES  26 B  487  ASN ILE LYS LEU THR ASP PRO ARG GLY LYS PRO PHE LYS
SEQRES  27 B  487  ASP PHE SER ILE ALA LYS THR ALA ASP VAL PHE GLU GLY
SEQRES  28 B  487  GLY PHE VAL HIS SER ALA ALA ILE LYS ASN PRO ALA ALA
SEQRES  29 B  487  GLY THR TRP LYS ILE ALA SER SER VAL LYS GLN LYS GLU
SEQRES  30 B  487  ALA PHE LEU PHE ILE VAL THR PHE ASP SER PRO LEU ASN
SEQRES  31 B  487  GLN GLN ILE LYS ASN ALA VAL THR ARG GLU SER SER ASN
SEQRES  32 B  487  LEU ALA ASN VAL LYS ALA SER VAL ARG SER ILE ARG TYR
SEQRES  33 B  487  GLU ASN GLY LYS GLN ALA GLU LYS LYS SER LEU LYS PRO
SEQRES  34 B  487  ALA SER ILE ASN ALA LEU GLN ASN SER LEU SER PHE LYS
SEQRES  35 B  487  LYS ALA GLY MET TYR SER VAL THR ILE ASP LEU SER GLY
SEQRES  36 B  487  LYS THR ALA ASP ASN SER PRO PHE ASN ARG THR ILE ILE
SEQRES  37 B  487  ARG SER ILE TYR VAL ASN ASP LYS GLY GLU LYS PHE GLU
SEQRES  38 B  487  ASN SER PRO LEU SER ASP
SEQRES   1 C  487  MET LYS LYS LEU VAL LEU LEU MET LEU VAL LEU LEU LEU
SEQRES   2 C  487  VAL TYR PRO HIS VAL SER LYS ALA GLY GLY PHE LYS GLY
SEQRES   3 C  487  GLY GLY GLY ASN PRO GLY TYR TRP PHE ALA GLY ASP PRO
SEQRES   4 C  487  VAL GLU HIS PRO ASP PRO ALA LYS PRO PRO ILE VAL PHE
SEQRES   5 C  487  VAL HIS GLY LEU ASN GLY SER SER SER ALA TRP PHE ASP
SEQRES   6 C  487  GLU ASN ASP MET ALA GLU GLN ALA TRP LYS ASN GLY TYR
SEQRES   7 C  487  ASP ALA ALA PHE ILE ASP LEU HIS PRO ASP LYS ASP MET
SEQRES   8 C  487  GLN ASP ASN GLY ALA MET LEU ALA ALA LYS LEU ARG GLU
SEQRES   9 C  487  ILE TYR GLN TYR PHE GLY ARG LYS VAL ILE LEU VAL SER
SEQRES  10 C  487  TYR SER LYS GLY GLY ILE ASP SER GLN SER ALA LEU ILE
SEQRES  11 C  487  HIS HIS ASN ALA TYR HIS TYR VAL GLU ARG VAL ILE THR
SEQRES  12 C  487  LEU GLY THR PRO HIS HIS GLY SER GLN LEU ALA ASP LEU
SEQRES  13 C  487  ALA TYR SER ASN TRP ALA GLY TRP LEU ALA ASP ILE LEU
SEQRES  14 C  487  GLY GLN LYS ASN ASP ALA VAL TYR SER LEU GLN THR GLY
SEQRES  15 C  487  PHE MET LYS SER PHE ARG ASP GLN THR ASP ASN HIS PRO
SEQRES  16 C  487  ASN ARG LEU LYS THR LYS TYR PHE THR LEU ALA GLY ASN
SEQRES  17 C  487  LYS ILE GLY GLY PHE GLY SER ALA LEU PHE PHE GLY GLY
SEQRES  18 C  487  VAL TYR LEU ASN MET PHE GLY GLU ASN ASP GLY ALA VAL
SEQRES  19 C  487  THR GLU LYS ASN ALA ARG LEU PRO TYR ALA THR ASN LEU
SEQRES  20 C  487  ASP THR GLY LYS TRP ASP HIS PHE SER ILE ILE LYS GLY
SEQRES  21 C  487  ASN LEU THR PHE PRO VAL PHE MET PRO LEU LEU THR ILE
SEQRES  22 C  487  GLN ALA ASN ALA ASN GLU THR ALA ALA THR LYS GLU ASN
SEQRES  23 C  487  LEU SER TYR PRO PHE ILE ARG GLY GLY GLU ASN HIS GLY
SEQRES  24 C  487  LEU ARG GLU GLU GLU PHE ALA VAL GLU LYS GLY VAL LYS
SEQRES  25 C  487  GLU ILE THR VAL HIS TRP LEU SER ASN HIS SER SER GLY
SEQRES  26 C  487  ASN ILE LYS LEU THR ASP PRO ARG GLY LYS PRO PHE LYS
SEQRES  27 C  487  ASP PHE SER ILE ALA LYS THR ALA ASP VAL PHE GLU GLY
SEQRES  28 C  487  GLY PHE VAL HIS SER ALA ALA ILE LYS ASN PRO ALA ALA
SEQRES  29 C  487  GLY THR TRP LYS ILE ALA SER SER VAL LYS GLN LYS GLU
SEQRES  30 C  487  ALA PHE LEU PHE ILE VAL THR PHE ASP SER PRO LEU ASN
SEQRES  31 C  487  GLN GLN ILE LYS ASN ALA VAL THR ARG GLU SER SER ASN
SEQRES  32 C  487  LEU ALA ASN VAL LYS ALA SER VAL ARG SER ILE ARG TYR
SEQRES  33 C  487  GLU ASN GLY LYS GLN ALA GLU LYS LYS SER LEU LYS PRO
SEQRES  34 C  487  ALA SER ILE ASN ALA LEU GLN ASN SER LEU SER PHE LYS
SEQRES  35 C  487  LYS ALA GLY MET TYR SER VAL THR ILE ASP LEU SER GLY
SEQRES  36 C  487  LYS THR ALA ASP ASN SER PRO PHE ASN ARG THR ILE ILE
SEQRES  37 C  487  ARG SER ILE TYR VAL ASN ASP LYS GLY GLU LYS PHE GLU
SEQRES  38 C  487  ASN SER PRO LEU SER ASP
SEQRES   1 D  487  MET LYS LYS LEU VAL LEU LEU MET LEU VAL LEU LEU LEU
SEQRES   2 D  487  VAL TYR PRO HIS VAL SER LYS ALA GLY GLY PHE LYS GLY
SEQRES   3 D  487  GLY GLY GLY ASN PRO GLY TYR TRP PHE ALA GLY ASP PRO
SEQRES   4 D  487  VAL GLU HIS PRO ASP PRO ALA LYS PRO PRO ILE VAL PHE
SEQRES   5 D  487  VAL HIS GLY LEU ASN GLY SER SER SER ALA TRP PHE ASP
SEQRES   6 D  487  GLU ASN ASP MET ALA GLU GLN ALA TRP LYS ASN GLY TYR
SEQRES   7 D  487  ASP ALA ALA PHE ILE ASP LEU HIS PRO ASP LYS ASP MET
SEQRES   8 D  487  GLN ASP ASN GLY ALA MET LEU ALA ALA LYS LEU ARG GLU
SEQRES   9 D  487  ILE TYR GLN TYR PHE GLY ARG LYS VAL ILE LEU VAL SER
SEQRES  10 D  487  TYR SER LYS GLY GLY ILE ASP SER GLN SER ALA LEU ILE
SEQRES  11 D  487  HIS HIS ASN ALA TYR HIS TYR VAL GLU ARG VAL ILE THR
SEQRES  12 D  487  LEU GLY THR PRO HIS HIS GLY SER GLN LEU ALA ASP LEU
SEQRES  13 D  487  ALA TYR SER ASN TRP ALA GLY TRP LEU ALA ASP ILE LEU
SEQRES  14 D  487  GLY GLN LYS ASN ASP ALA VAL TYR SER LEU GLN THR GLY
SEQRES  15 D  487  PHE MET LYS SER PHE ARG ASP GLN THR ASP ASN HIS PRO
SEQRES  16 D  487  ASN ARG LEU LYS THR LYS TYR PHE THR LEU ALA GLY ASN
SEQRES  17 D  487  LYS ILE GLY GLY PHE GLY SER ALA LEU PHE PHE GLY GLY
SEQRES  18 D  487  VAL TYR LEU ASN MET PHE GLY GLU ASN ASP GLY ALA VAL
SEQRES  19 D  487  THR GLU LYS ASN ALA ARG LEU PRO TYR ALA THR ASN LEU
SEQRES  20 D  487  ASP THR GLY LYS TRP ASP HIS PHE SER ILE ILE LYS GLY
SEQRES  21 D  487  ASN LEU THR PHE PRO VAL PHE MET PRO LEU LEU THR ILE
SEQRES  22 D  487  GLN ALA ASN ALA ASN GLU THR ALA ALA THR LYS GLU ASN
SEQRES  23 D  487  LEU SER TYR PRO PHE ILE ARG GLY GLY GLU ASN HIS GLY
SEQRES  24 D  487  LEU ARG GLU GLU GLU PHE ALA VAL GLU LYS GLY VAL LYS
SEQRES  25 D  487  GLU ILE THR VAL HIS TRP LEU SER ASN HIS SER SER GLY
SEQRES  26 D  487  ASN ILE LYS LEU THR ASP PRO ARG GLY LYS PRO PHE LYS
SEQRES  27 D  487  ASP PHE SER ILE ALA LYS THR ALA ASP VAL PHE GLU GLY
SEQRES  28 D  487  GLY PHE VAL HIS SER ALA ALA ILE LYS ASN PRO ALA ALA
SEQRES  29 D  487  GLY THR TRP LYS ILE ALA SER SER VAL LYS GLN LYS GLU
SEQRES  30 D  487  ALA PHE LEU PHE ILE VAL THR PHE ASP SER PRO LEU ASN
SEQRES  31 D  487  GLN GLN ILE LYS ASN ALA VAL THR ARG GLU SER SER ASN
SEQRES  32 D  487  LEU ALA ASN VAL LYS ALA SER VAL ARG SER ILE ARG TYR
SEQRES  33 D  487  GLU ASN GLY LYS GLN ALA GLU LYS LYS SER LEU LYS PRO
SEQRES  34 D  487  ALA SER ILE ASN ALA LEU GLN ASN SER LEU SER PHE LYS
SEQRES  35 D  487  LYS ALA GLY MET TYR SER VAL THR ILE ASP LEU SER GLY
SEQRES  36 D  487  LYS THR ALA ASP ASN SER PRO PHE ASN ARG THR ILE ILE
SEQRES  37 D  487  ARG SER ILE TYR VAL ASN ASP LYS GLY GLU LYS PHE GLU
SEQRES  38 D  487  ASN SER PRO LEU SER ASP
SEQRES   1 E  487  MET LYS LYS LEU VAL LEU LEU MET LEU VAL LEU LEU LEU
SEQRES   2 E  487  VAL TYR PRO HIS VAL SER LYS ALA GLY GLY PHE LYS GLY
SEQRES   3 E  487  GLY GLY GLY ASN PRO GLY TYR TRP PHE ALA GLY ASP PRO
SEQRES   4 E  487  VAL GLU HIS PRO ASP PRO ALA LYS PRO PRO ILE VAL PHE
SEQRES   5 E  487  VAL HIS GLY LEU ASN GLY SER SER SER ALA TRP PHE ASP
SEQRES   6 E  487  GLU ASN ASP MET ALA GLU GLN ALA TRP LYS ASN GLY TYR
SEQRES   7 E  487  ASP ALA ALA PHE ILE ASP LEU HIS PRO ASP LYS ASP MET
SEQRES   8 E  487  GLN ASP ASN GLY ALA MET LEU ALA ALA LYS LEU ARG GLU
SEQRES   9 E  487  ILE TYR GLN TYR PHE GLY ARG LYS VAL ILE LEU VAL SER
SEQRES  10 E  487  TYR SER LYS GLY GLY ILE ASP SER GLN SER ALA LEU ILE
SEQRES  11 E  487  HIS HIS ASN ALA TYR HIS TYR VAL GLU ARG VAL ILE THR
SEQRES  12 E  487  LEU GLY THR PRO HIS HIS GLY SER GLN LEU ALA ASP LEU
SEQRES  13 E  487  ALA TYR SER ASN TRP ALA GLY TRP LEU ALA ASP ILE LEU
SEQRES  14 E  487  GLY GLN LYS ASN ASP ALA VAL TYR SER LEU GLN THR GLY
SEQRES  15 E  487  PHE MET LYS SER PHE ARG ASP GLN THR ASP ASN HIS PRO
SEQRES  16 E  487  ASN ARG LEU LYS THR LYS TYR PHE THR LEU ALA GLY ASN
SEQRES  17 E  487  LYS ILE GLY GLY PHE GLY SER ALA LEU PHE PHE GLY GLY
SEQRES  18 E  487  VAL TYR LEU ASN MET PHE GLY GLU ASN ASP GLY ALA VAL
SEQRES  19 E  487  THR GLU LYS ASN ALA ARG LEU PRO TYR ALA THR ASN LEU
SEQRES  20 E  487  ASP THR GLY LYS TRP ASP HIS PHE SER ILE ILE LYS GLY
SEQRES  21 E  487  ASN LEU THR PHE PRO VAL PHE MET PRO LEU LEU THR ILE
SEQRES  22 E  487  GLN ALA ASN ALA ASN GLU THR ALA ALA THR LYS GLU ASN
SEQRES  23 E  487  LEU SER TYR PRO PHE ILE ARG GLY GLY GLU ASN HIS GLY
SEQRES  24 E  487  LEU ARG GLU GLU GLU PHE ALA VAL GLU LYS GLY VAL LYS
SEQRES  25 E  487  GLU ILE THR VAL HIS TRP LEU SER ASN HIS SER SER GLY
SEQRES  26 E  487  ASN ILE LYS LEU THR ASP PRO ARG GLY LYS PRO PHE LYS
SEQRES  27 E  487  ASP PHE SER ILE ALA LYS THR ALA ASP VAL PHE GLU GLY
SEQRES  28 E  487  GLY PHE VAL HIS SER ALA ALA ILE LYS ASN PRO ALA ALA
SEQRES  29 E  487  GLY THR TRP LYS ILE ALA SER SER VAL LYS GLN LYS GLU
SEQRES  30 E  487  ALA PHE LEU PHE ILE VAL THR PHE ASP SER PRO LEU ASN
SEQRES  31 E  487  GLN GLN ILE LYS ASN ALA VAL THR ARG GLU SER SER ASN
SEQRES  32 E  487  LEU ALA ASN VAL LYS ALA SER VAL ARG SER ILE ARG TYR
SEQRES  33 E  487  GLU ASN GLY LYS GLN ALA GLU LYS LYS SER LEU LYS PRO
SEQRES  34 E  487  ALA SER ILE ASN ALA LEU GLN ASN SER LEU SER PHE LYS
SEQRES  35 E  487  LYS ALA GLY MET TYR SER VAL THR ILE ASP LEU SER GLY
SEQRES  36 E  487  LYS THR ALA ASP ASN SER PRO PHE ASN ARG THR ILE ILE
SEQRES  37 E  487  ARG SER ILE TYR VAL ASN ASP LYS GLY GLU LYS PHE GLU
SEQRES  38 E  487  ASN SER PRO LEU SER ASP
SEQRES   1 F  487  MET LYS LYS LEU VAL LEU LEU MET LEU VAL LEU LEU LEU
SEQRES   2 F  487  VAL TYR PRO HIS VAL SER LYS ALA GLY GLY PHE LYS GLY
SEQRES   3 F  487  GLY GLY GLY ASN PRO GLY TYR TRP PHE ALA GLY ASP PRO
SEQRES   4 F  487  VAL GLU HIS PRO ASP PRO ALA LYS PRO PRO ILE VAL PHE
SEQRES   5 F  487  VAL HIS GLY LEU ASN GLY SER SER SER ALA TRP PHE ASP
SEQRES   6 F  487  GLU ASN ASP MET ALA GLU GLN ALA TRP LYS ASN GLY TYR
SEQRES   7 F  487  ASP ALA ALA PHE ILE ASP LEU HIS PRO ASP LYS ASP MET
SEQRES   8 F  487  GLN ASP ASN GLY ALA MET LEU ALA ALA LYS LEU ARG GLU
SEQRES   9 F  487  ILE TYR GLN TYR PHE GLY ARG LYS VAL ILE LEU VAL SER
SEQRES  10 F  487  TYR SER LYS GLY GLY ILE ASP SER GLN SER ALA LEU ILE
SEQRES  11 F  487  HIS HIS ASN ALA TYR HIS TYR VAL GLU ARG VAL ILE THR
SEQRES  12 F  487  LEU GLY THR PRO HIS HIS GLY SER GLN LEU ALA ASP LEU
SEQRES  13 F  487  ALA TYR SER ASN TRP ALA GLY TRP LEU ALA ASP ILE LEU
SEQRES  14 F  487  GLY GLN LYS ASN ASP ALA VAL TYR SER LEU GLN THR GLY
SEQRES  15 F  487  PHE MET LYS SER PHE ARG ASP GLN THR ASP ASN HIS PRO
SEQRES  16 F  487  ASN ARG LEU LYS THR LYS TYR PHE THR LEU ALA GLY ASN
SEQRES  17 F  487  LYS ILE GLY GLY PHE GLY SER ALA LEU PHE PHE GLY GLY
SEQRES  18 F  487  VAL TYR LEU ASN MET PHE GLY GLU ASN ASP GLY ALA VAL
SEQRES  19 F  487  THR GLU LYS ASN ALA ARG LEU PRO TYR ALA THR ASN LEU
SEQRES  20 F  487  ASP THR GLY LYS TRP ASP HIS PHE SER ILE ILE LYS GLY
SEQRES  21 F  487  ASN LEU THR PHE PRO VAL PHE MET PRO LEU LEU THR ILE
SEQRES  22 F  487  GLN ALA ASN ALA ASN GLU THR ALA ALA THR LYS GLU ASN
SEQRES  23 F  487  LEU SER TYR PRO PHE ILE ARG GLY GLY GLU ASN HIS GLY
SEQRES  24 F  487  LEU ARG GLU GLU GLU PHE ALA VAL GLU LYS GLY VAL LYS
SEQRES  25 F  487  GLU ILE THR VAL HIS TRP LEU SER ASN HIS SER SER GLY
SEQRES  26 F  487  ASN ILE LYS LEU THR ASP PRO ARG GLY LYS PRO PHE LYS
SEQRES  27 F  487  ASP PHE SER ILE ALA LYS THR ALA ASP VAL PHE GLU GLY
SEQRES  28 F  487  GLY PHE VAL HIS SER ALA ALA ILE LYS ASN PRO ALA ALA
SEQRES  29 F  487  GLY THR TRP LYS ILE ALA SER SER VAL LYS GLN LYS GLU
SEQRES  30 F  487  ALA PHE LEU PHE ILE VAL THR PHE ASP SER PRO LEU ASN
SEQRES  31 F  487  GLN GLN ILE LYS ASN ALA VAL THR ARG GLU SER SER ASN
SEQRES  32 F  487  LEU ALA ASN VAL LYS ALA SER VAL ARG SER ILE ARG TYR
SEQRES  33 F  487  GLU ASN GLY LYS GLN ALA GLU LYS LYS SER LEU LYS PRO
SEQRES  34 F  487  ALA SER ILE ASN ALA LEU GLN ASN SER LEU SER PHE LYS
SEQRES  35 F  487  LYS ALA GLY MET TYR SER VAL THR ILE ASP LEU SER GLY
SEQRES  36 F  487  LYS THR ALA ASP ASN SER PRO PHE ASN ARG THR ILE ILE
SEQRES  37 F  487  ARG SER ILE TYR VAL ASN ASP LYS GLY GLU LYS PHE GLU
SEQRES  38 F  487  ASN SER PRO LEU SER ASP
FORMUL   7  HOH   *279(H2 O)
HELIX    1 AA1 SER A   59  PHE A   64  5                                   6
HELIX    2 AA2 ASP A   68  ASN A   76  1                                   9
HELIX    3 AA3 ASP A   90  GLY A  110  1                                  21
HELIX    4 AA4 LYS A  120  HIS A  132  1                                  13
HELIX    5 AA5 ASN A  133  HIS A  136  5                                   4
HELIX    6 AA6 SER A  151  TYR A  158  1                                   8
HELIX    7 AA7 TRP A  164  GLY A  170  1                                   7
HELIX    8 AA8 ASN A  173  SER A  178  1                                   6
HELIX    9 AA9 GLN A  180  ASP A  192  1                                  13
HELIX   10 AB1 HIS A  194  THR A  200  5                                   7
HELIX   11 AB2 SER A  215  ASN A  225  1                                  11
HELIX   12 AB3 GLU A  236  ARG A  240  5                                   5
HELIX   13 AB4 PHE A  255  ILE A  258  5                                   4
HELIX   14 AB5 LYS A  259  MET A  268  1                                  10
HELIX   15 AB6 PRO A  269  LEU A  271  5                                   3
HELIX   16 AB7 SER B   59  PHE B   64  5                                   6
HELIX   17 AB8 ASP B   68  ASN B   76  1                                   9
HELIX   18 AB9 ASP B   90  GLY B  110  1                                  21
HELIX   19 AC1 LYS B  120  HIS B  132  1                                  13
HELIX   20 AC2 ASN B  133  HIS B  136  5                                   4
HELIX   21 AC3 SER B  151  TYR B  158  1                                   8
HELIX   22 AC4 ALA B  162  GLY B  170  1                                   9
HELIX   23 AC5 ASN B  173  SER B  178  1                                   6
HELIX   24 AC6 GLN B  180  ASP B  192  1                                  13
HELIX   25 AC7 HIS B  194  THR B  200  5                                   7
HELIX   26 AC8 SER B  215  ASN B  225  1                                  11
HELIX   27 AC9 GLU B  236  ARG B  240  5                                   5
HELIX   28 AD1 PHE B  255  ILE B  258  5                                   4
HELIX   29 AD2 LYS B  259  MET B  268  1                                  10
HELIX   30 AD3 PRO B  269  LEU B  271  5                                   3
HELIX   31 AD4 SER C   59  PHE C   64  5                                   6
HELIX   32 AD5 ASP C   68  ASN C   76  1                                   9
HELIX   33 AD6 ASP C   90  GLY C  110  1                                  21
HELIX   34 AD7 SER C  119  HIS C  132  1                                  14
HELIX   35 AD8 ASN C  133  HIS C  136  5                                   4
HELIX   36 AD9 SER C  151  TRP C  161  1                                  11
HELIX   37 AE1 TRP C  164  GLY C  170  1                                   7
HELIX   38 AE2 ASN C  173  SER C  178  1                                   6
HELIX   39 AE3 GLN C  180  ASN C  193  1                                  14
HELIX   40 AE4 HIS C  194  THR C  200  5                                   7
HELIX   41 AE5 SER C  215  ASN C  225  1                                  11
HELIX   42 AE6 GLU C  236  ARG C  240  5                                   5
HELIX   43 AE7 PHE C  255  ILE C  258  5                                   4
HELIX   44 AE8 LYS C  259  MET C  268  1                                  10
HELIX   45 AE9 PRO C  269  LEU C  271  5                                   3
HELIX   46 AF1 SER D   59  PHE D   64  5                                   6
HELIX   47 AF2 ASP D   68  ASN D   76  1                                   9
HELIX   48 AF3 ASP D   90  GLY D  110  1                                  21
HELIX   49 AF4 LYS D  120  HIS D  132  1                                  13
HELIX   50 AF5 ASN D  133  HIS D  136  5                                   4
HELIX   51 AF6 SER D  151  SER D  159  1                                   9
HELIX   52 AF7 ALA D  162  TRP D  164  5                                   3
HELIX   53 AF8 LEU D  165  GLY D  170  1                                   6
HELIX   54 AF9 ASN D  173  SER D  178  1                                   6
HELIX   55 AG1 GLN D  180  ASN D  193  1                                  14
HELIX   56 AG2 HIS D  194  THR D  200  5                                   7
HELIX   57 AG3 SER D  215  ASN D  225  1                                  11
HELIX   58 AG4 GLU D  236  ARG D  240  5                                   5
HELIX   59 AG5 PHE D  255  ILE D  258  5                                   4
HELIX   60 AG6 LYS D  259  MET D  268  1                                  10
HELIX   61 AG7 PRO D  269  LEU D  271  5                                   3
HELIX   62 AG8 SER E   59  PHE E   64  5                                   6
HELIX   63 AG9 ASP E   68  ASN E   76  1                                   9
HELIX   64 AH1 ASP E   90  GLY E  110  1                                  21
HELIX   65 AH2 LYS E  120  HIS E  132  1                                  13
HELIX   66 AH3 ASN E  133  HIS E  136  5                                   4
HELIX   67 AH4 SER E  151  TYR E  158  1                                   8
HELIX   68 AH5 LEU E  165  GLY E  170  1                                   6
HELIX   69 AH6 ASN E  173  SER E  178  1                                   6
HELIX   70 AH7 GLN E  180  ASP E  192  1                                  13
HELIX   71 AH8 HIS E  194  THR E  200  5                                   7
HELIX   72 AH9 PHE E  218  ASN E  225  1                                   8
HELIX   73 AI1 GLU E  236  ARG E  240  5                                   5
HELIX   74 AI2 PHE E  255  ILE E  258  5                                   4
HELIX   75 AI3 LYS E  259  MET E  268  1                                  10
HELIX   76 AI4 PRO E  269  LEU E  271  5                                   3
HELIX   77 AI5 SER F   59  PHE F   64  5                                   6
HELIX   78 AI6 ASP F   68  ASN F   76  1                                   9
HELIX   79 AI7 ASP F   90  GLY F  110  1                                  21
HELIX   80 AI8 LYS F  120  HIS F  132  1                                  13
HELIX   81 AI9 ASN F  133  HIS F  136  5                                   4
HELIX   82 AJ1 SER F  151  TRP F  161  1                                  11
HELIX   83 AJ2 LEU F  165  GLY F  170  1                                   6
HELIX   84 AJ3 ASN F  173  SER F  178  1                                   6
HELIX   85 AJ4 GLN F  180  ASN F  193  1                                  14
HELIX   86 AJ5 HIS F  194  THR F  200  5                                   7
HELIX   87 AJ6 SER F  215  ASN F  225  1                                  11
HELIX   88 AJ7 GLU F  236  ARG F  240  5                                   5
HELIX   89 AJ8 PHE F  255  ILE F  258  5                                   4
HELIX   90 AJ9 LYS F  259  MET F  268  1                                  10
HELIX   91 AK1 PRO F  269  LEU F  271  5                                   3
SHEET    1 AA1 7 TRP A  34  ALA A  36  0
SHEET    2 AA1 7 ALA A  80  ILE A  83 -1  O  PHE A  82   N  PHE A  35
SHEET    3 AA1 7 ILE A  50  VAL A  53  1  N  PHE A  52   O  ALA A  81
SHEET    4 AA1 7 VAL A 113  TYR A 118  1  O  ILE A 114   N  VAL A  51
SHEET    5 AA1 7 VAL A 138  LEU A 144  1  O  ILE A 142   N  LEU A 115
SHEET    6 AA1 7 LYS A 201  LEU A 205  1  O  PHE A 203   N  THR A 143
SHEET    7 AA1 7 THR A 245  ASN A 246  1  O  THR A 245   N  TYR A 202
SHEET    1 AA2 7 TRP B  34  ALA B  36  0
SHEET    2 AA2 7 ALA B  80  ILE B  83 -1  O  PHE B  82   N  PHE B  35
SHEET    3 AA2 7 ILE B  50  VAL B  53  1  N  PHE B  52   O  ALA B  81
SHEET    4 AA2 7 VAL B 113  TYR B 118  1  O  ILE B 114   N  VAL B  51
SHEET    5 AA2 7 VAL B 138  LEU B 144  1  O  ILE B 142   N  LEU B 115
SHEET    6 AA2 7 LYS B 201  LEU B 205  1  O  PHE B 203   N  THR B 143
SHEET    7 AA2 7 THR B 245  ASN B 246  1  O  THR B 245   N  TYR B 202
SHEET    1 AA3 7 TRP C  34  GLY C  37  0
SHEET    2 AA3 7 ALA C  80  ILE C  83 -1  O  PHE C  82   N  PHE C  35
SHEET    3 AA3 7 ILE C  50  VAL C  53  1  N  ILE C  50   O  ALA C  81
SHEET    4 AA3 7 VAL C 113  TYR C 118  1  O  ILE C 114   N  VAL C  51
SHEET    5 AA3 7 VAL C 138  LEU C 144  1  O  ILE C 142   N  LEU C 115
SHEET    6 AA3 7 LYS C 201  LEU C 205  1  O  PHE C 203   N  THR C 143
SHEET    7 AA3 7 THR C 245  ASN C 246  1  O  THR C 245   N  TYR C 202
SHEET    1 AA4 7 TRP D  34  ALA D  36  0
SHEET    2 AA4 7 ALA D  80  ILE D  83 -1  O  PHE D  82   N  PHE D  35
SHEET    3 AA4 7 ILE D  50  VAL D  53  1  N  PHE D  52   O  ALA D  81
SHEET    4 AA4 7 VAL D 113  TYR D 118  1  O  ILE D 114   N  VAL D  51
SHEET    5 AA4 7 VAL D 138  LEU D 144  1  O  ILE D 142   N  LEU D 115
SHEET    6 AA4 7 LYS D 201  LEU D 205  1  O  PHE D 203   N  THR D 143
SHEET    7 AA4 7 THR D 245  ASN D 246  1  O  THR D 245   N  TYR D 202
SHEET    1 AA5 7 TRP E  34  ALA E  36  0
SHEET    2 AA5 7 ALA E  80  ILE E  83 -1  O  PHE E  82   N  PHE E  35
SHEET    3 AA5 7 ILE E  50  VAL E  53  1  N  PHE E  52   O  ALA E  81
SHEET    4 AA5 7 VAL E 113  TYR E 118  1  O  ILE E 114   N  VAL E  51
SHEET    5 AA5 7 VAL E 138  LEU E 144  1  O  ILE E 142   N  LEU E 115
SHEET    6 AA5 7 LYS E 201  LEU E 205  1  O  PHE E 203   N  THR E 143
SHEET    7 AA5 7 THR E 245  ASN E 246  1  O  THR E 245   N  TYR E 202
SHEET    1 AA6 7 TRP F  34  ALA F  36  0
SHEET    2 AA6 7 ALA F  80  ILE F  83 -1  O  PHE F  82   N  PHE F  35
SHEET    3 AA6 7 ILE F  50  VAL F  53  1  N  PHE F  52   O  ALA F  81
SHEET    4 AA6 7 VAL F 113  TYR F 118  1  O  ILE F 114   N  VAL F  51
SHEET    5 AA6 7 VAL F 138  LEU F 144  1  O  ILE F 142   N  LEU F 115
SHEET    6 AA6 7 LYS F 201  LEU F 205  1  O  PHE F 203   N  THR F 143
SHEET    7 AA6 7 THR F 245  ASN F 246  1  O  THR F 245   N  TYR F 202
CRYST1  102.077  122.518  157.920  90.00  90.00  90.00 P 21 2 21    24
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.009797  0.000000  0.000000        0.00000
SCALE2      0.000000  0.008162  0.000000        0.00000
SCALE3      0.000000  0.000000  0.006332        0.00000
TER    1936      ILE A 273
TER    3872      ILE B 273
TER    5808      ILE C 273
TER    7744      ILE D 273
TER    9680      ILE E 273
TER   11616      ILE F 273
MASTER     1844    0    0   91   42    0    0    611859    6    0  228
END