| content |
HEADER IMMUNE SYSTEM 27-MAY-20 6X6A
TITLE CRYO-EM STRUCTURE OF NLRP1-DPP9 COMPLEX
COMPND MOL_ID: 1;
COMPND 2 MOLECULE: DIPEPTIDYL PEPTIDASE 9;
COMPND 3 CHAIN: A, D;
COMPND 4 SYNONYM: DP9,DIPEPTIDYL PEPTIDASE IV-RELATED PROTEIN 2,DPRP-2,
COMPND 5 DIPEPTIDYL PEPTIDASE IX,DPP IX,DIPEPTIDYL PEPTIDASE-LIKE PROTEIN 9,
COMPND 6 DPLP9;
COMPND 7 EC: 3.4.14.5;
COMPND 8 ENGINEERED: YES;
COMPND 9 MOL_ID: 2;
COMPND 10 MOLECULE: NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1;
COMPND 11 CHAIN: B, E;
COMPND 12 SYNONYM: CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 7,DEATH
COMPND 13 EFFECTOR FILAMENT-FORMING CED-4-LIKE APOPTOSIS PROTEIN,NUCLEOTIDE-
COMPND 14 BINDING DOMAIN AND CASPASE RECRUITMENT DOMAIN;
COMPND 15 ENGINEERED: YES;
COMPND 16 MOL_ID: 3;
COMPND 17 MOLECULE: NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1;
COMPND 18 CHAIN: G, C, I, F;
COMPND 19 SYNONYM: CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 7,DEATH
COMPND 20 EFFECTOR FILAMENT-FORMING CED-4-LIKE APOPTOSIS PROTEIN,NUCLEOTIDE-
COMPND 21 BINDING DOMAIN AND CASPASE RECRUITMENT DOMAIN;
COMPND 22 ENGINEERED: YES
SOURCE MOL_ID: 1;
SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 3 ORGANISM_COMMON: HUMAN;
SOURCE 4 ORGANISM_TAXID: 9606;
SOURCE 5 GENE: DPP9, DPRP2;
SOURCE 6 EXPRESSION_SYSTEM: HOMO SAPIENS;
SOURCE 7 EXPRESSION_SYSTEM_COMMON: HUMAN;
SOURCE 8 EXPRESSION_SYSTEM_TAXID: 9606;
SOURCE 9 EXPRESSION_SYSTEM_CELL_LINE: HEK293;
SOURCE 10 MOL_ID: 2;
SOURCE 11 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 12 ORGANISM_COMMON: HUMAN;
SOURCE 13 ORGANISM_TAXID: 9606;
SOURCE 14 GENE: NLRP1, CARD7, DEFCAP, KIAA0926, NAC, NALP1;
SOURCE 15 EXPRESSION_SYSTEM: HOMO SAPIENS;
SOURCE 16 EXPRESSION_SYSTEM_COMMON: HUMAN;
SOURCE 17 EXPRESSION_SYSTEM_TAXID: 9606;
SOURCE 18 EXPRESSION_SYSTEM_CELL_LINE: HEK293;
SOURCE 19 MOL_ID: 3;
SOURCE 20 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 21 ORGANISM_COMMON: HUMAN;
SOURCE 22 ORGANISM_TAXID: 9606;
SOURCE 23 GENE: NLRP1, CARD7, DEFCAP, KIAA0926, NAC, NALP1;
SOURCE 24 EXPRESSION_SYSTEM: HOMO SAPIENS;
SOURCE 25 EXPRESSION_SYSTEM_COMMON: HUMAN;
SOURCE 26 EXPRESSION_SYSTEM_TAXID: 9606;
SOURCE 27 EXPRESSION_SYSTEM_CELL_LINE: HEK293
KEYWDS NLRP1, DPP9, INFLAMMASOME, VAL-BOROPRO (VBP), TALABOSTAT, INNATE
KEYWDS 2 IMMUNITY, IMMUNE SYSTEM
EXPDTA ELECTRON MICROSCOPY
AUTHOR L.R.HOLLINGSWORTH,H.SHARIF
REVDAT 1 10-MAR-21 6X6A 0
JRNL AUTH L.R.HOLLINGSWORTH,H.SHARIF
JRNL TITL DPP9 DIRECTLY SEQUESTERS THE NLRP1 C-TERMINUS TO REPRESS
JRNL TITL 2 INFLAMMASOME ACTIVATION
JRNL REF TO BE PUBLISHED
JRNL REFN
REMARK 2
REMARK 2 RESOLUTION. 3.60 ANGSTROMS.
REMARK 3
REMARK 3 REFINEMENT.
REMARK 3 SOFTWARE PACKAGES : SERIALEM, CTFFIND, RELION, RELION,
REMARK 3 RELION, RELION
REMARK 3 RECONSTRUCTION SCHEMA : FOURIER SPACE
REMARK 3
REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT
REMARK 3 PDB ENTRY : NULL
REMARK 3 REFINEMENT SPACE : NULL
REMARK 3 REFINEMENT PROTOCOL : NULL
REMARK 3 REFINEMENT TARGET : NULL
REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL
REMARK 3
REMARK 3 FITTING PROCEDURE : NULL
REMARK 3
REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS
REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.600
REMARK 3 NUMBER OF PARTICLES : 179306
REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE
REMARK 3 CORRECTION
REMARK 3
REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL
REMARK 3
REMARK 3 OTHER DETAILS: NULL
REMARK 4
REMARK 4 6X6A COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 28-MAY-20.
REMARK 100 THE DEPOSITION ID IS D_1000249655.
REMARK 245
REMARK 245 EXPERIMENTAL DETAILS
REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE
REMARK 245 SPECIMEN TYPE : NULL
REMARK 245
REMARK 245 ELECTRON MICROSCOPE SAMPLE
REMARK 245 SAMPLE TYPE : PARTICLE
REMARK 245 PARTICLE TYPE : POINT
REMARK 245 NAME OF SAMPLE : DPP9-NLRP1 COMPLEX
REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 0.50
REMARK 245 SAMPLE SUPPORT DETAILS : NULL
REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL
REMARK 245 SAMPLE BUFFER : NULL
REMARK 245 PH : 7.50
REMARK 245 SAMPLE DETAILS : NULL
REMARK 245
REMARK 245 DATA ACQUISITION
REMARK 245 DATE OF EXPERIMENT : NULL
REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : 1916
REMARK 245 TEMPERATURE (KELVIN) : NULL
REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS
REMARK 245 DETECTOR TYPE : GATAN K3 BIOQUANTUM (6K X
REMARK 245 4K)
REMARK 245 MINIMUM DEFOCUS (NM) : -1000.00
REMARK 245 MAXIMUM DEFOCUS (NM) : 2500.00
REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 NOMINAL CS : 2.70
REMARK 245 IMAGING MODE : OTHER
REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 67.60
REMARK 245 ILLUMINATION MODE : SPOT SCAN
REMARK 245 NOMINAL MAGNIFICATION : NULL
REMARK 245 CALIBRATED MAGNIFICATION : 10500
REMARK 245 SOURCE : OTHER
REMARK 245 ACCELERATION VOLTAGE (KV) : 300
REMARK 245 IMAGING DETAILS : NULL
REMARK 247
REMARK 247 ELECTRON MICROSCOPY
REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON
REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE
REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES
REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION
REMARK 247 OF THE STRUCTURE FACTORS.
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: OCTAMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, G, C, D, E, I, F
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465 M RES C SSSEQI
REMARK 465 MET A 1
REMARK 465 ALA A 2
REMARK 465 THR A 3
REMARK 465 THR A 4
REMARK 465 GLY A 5
REMARK 465 THR A 6
REMARK 465 PRO A 7
REMARK 465 THR A 8
REMARK 465 ALA A 9
REMARK 465 ASP A 10
REMARK 465 ARG A 11
REMARK 465 GLY A 12
REMARK 465 ASP A 13
REMARK 465 ALA A 14
REMARK 465 ALA A 15
REMARK 465 ALA A 16
REMARK 465 THR A 17
REMARK 465 MET B 1
REMARK 465 ALA B 2
REMARK 465 GLY B 3
REMARK 465 GLY B 4
REMARK 465 ALA B 5
REMARK 465 TRP B 6
REMARK 465 GLY B 7
REMARK 465 ARG B 8
REMARK 465 LEU B 9
REMARK 465 ALA B 10
REMARK 465 CYS B 11
REMARK 465 TYR B 12
REMARK 465 LEU B 13
REMARK 465 GLU B 14
REMARK 465 PHE B 15
REMARK 465 LEU B 16
REMARK 465 LYS B 17
REMARK 465 LYS B 18
REMARK 465 GLU B 19
REMARK 465 GLU B 20
REMARK 465 LEU B 21
REMARK 465 LYS B 22
REMARK 465 GLU B 23
REMARK 465 PHE B 24
REMARK 465 GLN B 25
REMARK 465 LEU B 26
REMARK 465 LEU B 27
REMARK 465 LEU B 28
REMARK 465 ALA B 29
REMARK 465 ASN B 30
REMARK 465 LYS B 31
REMARK 465 ALA B 32
REMARK 465 HIS B 33
REMARK 465 SER B 34
REMARK 465 ARG B 35
REMARK 465 SER B 36
REMARK 465 SER B 37
REMARK 465 SER B 38
REMARK 465 GLY B 39
REMARK 465 GLU B 40
REMARK 465 THR B 41
REMARK 465 PRO B 42
REMARK 465 ALA B 43
REMARK 465 GLN B 44
REMARK 465 PRO B 45
REMARK 465 GLU B 46
REMARK 465 LYS B 47
REMARK 465 THR B 48
REMARK 465 SER B 49
REMARK 465 GLY B 50
REMARK 465 MET B 51
REMARK 465 GLU B 52
REMARK 465 VAL B 53
REMARK 465 ALA B 54
REMARK 465 SER B 55
REMARK 465 TYR B 56
REMARK 465 LEU B 57
REMARK 465 VAL B 58
REMARK 465 ALA B 59
REMARK 465 GLN B 60
REMARK 465 TYR B 61
REMARK 465 GLY B 62
REMARK 465 GLU B 63
REMARK 465 GLN B 64
REMARK 465 ARG B 65
REMARK 465 ALA B 66
REMARK 465 TRP B 67
REMARK 465 ASP B 68
REMARK 465 LEU B 69
REMARK 465 ALA B 70
REMARK 465 LEU B 71
REMARK 465 HIS B 72
REMARK 465 THR B 73
REMARK 465 TRP B 74
REMARK 465 GLU B 75
REMARK 465 GLN B 76
REMARK 465 MET B 77
REMARK 465 GLY B 78
REMARK 465 LEU B 79
REMARK 465 ARG B 80
REMARK 465 SER B 81
REMARK 465 LEU B 82
REMARK 465 CYS B 83
REMARK 465 ALA B 84
REMARK 465 GLN B 85
REMARK 465 ALA B 86
REMARK 465 GLN B 87
REMARK 465 GLU B 88
REMARK 465 GLY B 89
REMARK 465 ALA B 90
REMARK 465 GLY B 91
REMARK 465 HIS B 92
REMARK 465 SER B 93
REMARK 465 PRO B 94
REMARK 465 SER B 95
REMARK 465 PHE B 96
REMARK 465 PRO B 97
REMARK 465 TYR B 98
REMARK 465 SER B 99
REMARK 465 PRO B 100
REMARK 465 SER B 101
REMARK 465 GLU B 102
REMARK 465 PRO B 103
REMARK 465 HIS B 104
REMARK 465 LEU B 105
REMARK 465 GLY B 106
REMARK 465 SER B 107
REMARK 465 PRO B 108
REMARK 465 SER B 109
REMARK 465 GLN B 110
REMARK 465 PRO B 111
REMARK 465 THR B 112
REMARK 465 SER B 113
REMARK 465 THR B 114
REMARK 465 ALA B 115
REMARK 465 VAL B 116
REMARK 465 LEU B 117
REMARK 465 MET B 118
REMARK 465 PRO B 119
REMARK 465 TRP B 120
REMARK 465 ILE B 121
REMARK 465 HIS B 122
REMARK 465 GLU B 123
REMARK 465 LEU B 124
REMARK 465 PRO B 125
REMARK 465 ALA B 126
REMARK 465 GLY B 127
REMARK 465 CYS B 128
REMARK 465 THR B 129
REMARK 465 GLN B 130
REMARK 465 GLY B 131
REMARK 465 SER B 132
REMARK 465 GLU B 133
REMARK 465 ARG B 134
REMARK 465 ARG B 135
REMARK 465 VAL B 136
REMARK 465 LEU B 137
REMARK 465 ARG B 138
REMARK 465 GLN B 139
REMARK 465 LEU B 140
REMARK 465 PRO B 141
REMARK 465 ASP B 142
REMARK 465 THR B 143
REMARK 465 SER B 144
REMARK 465 GLY B 145
REMARK 465 ARG B 146
REMARK 465 ARG B 147
REMARK 465 TRP B 148
REMARK 465 ARG B 149
REMARK 465 GLU B 150
REMARK 465 ILE B 151
REMARK 465 SER B 152
REMARK 465 ALA B 153
REMARK 465 SER B 154
REMARK 465 LEU B 155
REMARK 465 LEU B 156
REMARK 465 TYR B 157
REMARK 465 GLN B 158
REMARK 465 ALA B 159
REMARK 465 LEU B 160
REMARK 465 PRO B 161
REMARK 465 SER B 162
REMARK 465 SER B 163
REMARK 465 PRO B 164
REMARK 465 ASP B 165
REMARK 465 HIS B 166
REMARK 465 GLU B 167
REMARK 465 SER B 168
REMARK 465 PRO B 169
REMARK 465 SER B 170
REMARK 465 GLN B 171
REMARK 465 GLU B 172
REMARK 465 SER B 173
REMARK 465 PRO B 174
REMARK 465 ASN B 175
REMARK 465 ALA B 176
REMARK 465 PRO B 177
REMARK 465 THR B 178
REMARK 465 SER B 179
REMARK 465 THR B 180
REMARK 465 ALA B 181
REMARK 465 VAL B 182
REMARK 465 LEU B 183
REMARK 465 GLY B 184
REMARK 465 SER B 185
REMARK 465 TRP B 186
REMARK 465 GLY B 187
REMARK 465 SER B 188
REMARK 465 PRO B 189
REMARK 465 PRO B 190
REMARK 465 GLN B 191
REMARK 465 PRO B 192
REMARK 465 SER B 193
REMARK 465 LEU B 194
REMARK 465 ALA B 195
REMARK 465 PRO B 196
REMARK 465 ARG B 197
REMARK 465 GLU B 198
REMARK 465 GLN B 199
REMARK 465 GLU B 200
REMARK 465 ALA B 201
REMARK 465 PRO B 202
REMARK 465 GLY B 203
REMARK 465 THR B 204
REMARK 465 GLN B 205
REMARK 465 TRP B 206
REMARK 465 PRO B 207
REMARK 465 LEU B 208
REMARK 465 ASP B 209
REMARK 465 GLU B 210
REMARK 465 THR B 211
REMARK 465 SER B 212
REMARK 465 GLY B 213
REMARK 465 ILE B 214
REMARK 465 TYR B 215
REMARK 465 TYR B 216
REMARK 465 THR B 217
REMARK 465 GLU B 218
REMARK 465 ILE B 219
REMARK 465 ARG B 220
REMARK 465 GLU B 221
REMARK 465 ARG B 222
REMARK 465 GLU B 223
REMARK 465 ARG B 224
REMARK 465 GLU B 225
REMARK 465 LYS B 226
REMARK 465 SER B 227
REMARK 465 GLU B 228
REMARK 465 LYS B 229
REMARK 465 GLY B 230
REMARK 465 ARG B 231
REMARK 465 PRO B 232
REMARK 465 PRO B 233
REMARK 465 TRP B 234
REMARK 465 ALA B 235
REMARK 465 ALA B 236
REMARK 465 VAL B 237
REMARK 465 VAL B 238
REMARK 465 GLY B 239
REMARK 465 THR B 240
REMARK 465 PRO B 241
REMARK 465 PRO B 242
REMARK 465 GLN B 243
REMARK 465 ALA B 244
REMARK 465 HIS B 245
REMARK 465 THR B 246
REMARK 465 SER B 247
REMARK 465 LEU B 248
REMARK 465 GLN B 249
REMARK 465 PRO B 250
REMARK 465 HIS B 251
REMARK 465 HIS B 252
REMARK 465 HIS B 253
REMARK 465 PRO B 254
REMARK 465 TRP B 255
REMARK 465 GLU B 256
REMARK 465 PRO B 257
REMARK 465 SER B 258
REMARK 465 VAL B 259
REMARK 465 ARG B 260
REMARK 465 GLU B 261
REMARK 465 SER B 262
REMARK 465 LEU B 263
REMARK 465 CYS B 264
REMARK 465 SER B 265
REMARK 465 THR B 266
REMARK 465 TRP B 267
REMARK 465 PRO B 268
REMARK 465 TRP B 269
REMARK 465 LYS B 270
REMARK 465 ASN B 271
REMARK 465 GLU B 272
REMARK 465 ASP B 273
REMARK 465 PHE B 274
REMARK 465 ASN B 275
REMARK 465 GLN B 276
REMARK 465 LYS B 277
REMARK 465 PHE B 278
REMARK 465 THR B 279
REMARK 465 GLN B 280
REMARK 465 LEU B 281
REMARK 465 LEU B 282
REMARK 465 LEU B 283
REMARK 465 LEU B 284
REMARK 465 GLN B 285
REMARK 465 ARG B 286
REMARK 465 PRO B 287
REMARK 465 HIS B 288
REMARK 465 PRO B 289
REMARK 465 ARG B 290
REMARK 465 SER B 291
REMARK 465 GLN B 292
REMARK 465 ASP B 293
REMARK 465 PRO B 294
REMARK 465 LEU B 295
REMARK 465 VAL B 296
REMARK 465 LYS B 297
REMARK 465 ARG B 298
REMARK 465 SER B 299
REMARK 465 TRP B 300
REMARK 465 PRO B 301
REMARK 465 ASP B 302
REMARK 465 TYR B 303
REMARK 465 VAL B 304
REMARK 465 GLU B 305
REMARK 465 GLU B 306
REMARK 465 ASN B 307
REMARK 465 ARG B 308
REMARK 465 GLY B 309
REMARK 465 HIS B 310
REMARK 465 LEU B 311
REMARK 465 ILE B 312
REMARK 465 GLU B 313
REMARK 465 ILE B 314
REMARK 465 ARG B 315
REMARK 465 ASP B 316
REMARK 465 LEU B 317
REMARK 465 PHE B 318
REMARK 465 GLY B 319
REMARK 465 PRO B 320
REMARK 465 GLY B 321
REMARK 465 LEU B 322
REMARK 465 ASP B 323
REMARK 465 THR B 324
REMARK 465 GLN B 325
REMARK 465 GLU B 326
REMARK 465 PRO B 327
REMARK 465 ARG B 328
REMARK 465 ILE B 329
REMARK 465 VAL B 330
REMARK 465 ILE B 331
REMARK 465 LEU B 332
REMARK 465 GLN B 333
REMARK 465 GLY B 334
REMARK 465 ALA B 335
REMARK 465 ALA B 336
REMARK 465 GLY B 337
REMARK 465 ILE B 338
REMARK 465 GLY B 339
REMARK 465 LYS B 340
REMARK 465 SER B 341
REMARK 465 THR B 342
REMARK 465 LEU B 343
REMARK 465 ALA B 344
REMARK 465 ARG B 345
REMARK 465 GLN B 346
REMARK 465 VAL B 347
REMARK 465 LYS B 348
REMARK 465 GLU B 349
REMARK 465 ALA B 350
REMARK 465 TRP B 351
REMARK 465 GLY B 352
REMARK 465 ARG B 353
REMARK 465 GLY B 354
REMARK 465 GLN B 355
REMARK 465 LEU B 356
REMARK 465 TYR B 357
REMARK 465 GLY B 358
REMARK 465 ASP B 359
REMARK 465 ARG B 360
REMARK 465 PHE B 361
REMARK 465 GLN B 362
REMARK 465 HIS B 363
REMARK 465 VAL B 364
REMARK 465 PHE B 365
REMARK 465 TYR B 366
REMARK 465 PHE B 367
REMARK 465 SER B 368
REMARK 465 CYS B 369
REMARK 465 ARG B 370
REMARK 465 GLU B 371
REMARK 465 LEU B 372
REMARK 465 ALA B 373
REMARK 465 GLN B 374
REMARK 465 SER B 375
REMARK 465 LYS B 376
REMARK 465 VAL B 377
REMARK 465 VAL B 378
REMARK 465 SER B 379
REMARK 465 LEU B 380
REMARK 465 ALA B 381
REMARK 465 GLU B 382
REMARK 465 LEU B 383
REMARK 465 ILE B 384
REMARK 465 GLY B 385
REMARK 465 LYS B 386
REMARK 465 ASP B 387
REMARK 465 GLY B 388
REMARK 465 THR B 389
REMARK 465 ALA B 390
REMARK 465 THR B 391
REMARK 465 PRO B 392
REMARK 465 ALA B 393
REMARK 465 PRO B 394
REMARK 465 ILE B 395
REMARK 465 ARG B 396
REMARK 465 GLN B 397
REMARK 465 ILE B 398
REMARK 465 LEU B 399
REMARK 465 SER B 400
REMARK 465 ARG B 401
REMARK 465 PRO B 402
REMARK 465 GLU B 403
REMARK 465 ARG B 404
REMARK 465 LEU B 405
REMARK 465 LEU B 406
REMARK 465 PHE B 407
REMARK 465 ILE B 408
REMARK 465 LEU B 409
REMARK 465 ASP B 410
REMARK 465 GLY B 411
REMARK 465 VAL B 412
REMARK 465 ASP B 413
REMARK 465 GLU B 414
REMARK 465 PRO B 415
REMARK 465 GLY B 416
REMARK 465 TRP B 417
REMARK 465 VAL B 418
REMARK 465 LEU B 419
REMARK 465 GLN B 420
REMARK 465 GLU B 421
REMARK 465 PRO B 422
REMARK 465 SER B 423
REMARK 465 SER B 424
REMARK 465 GLU B 425
REMARK 465 LEU B 426
REMARK 465 CYS B 427
REMARK 465 LEU B 428
REMARK 465 HIS B 429
REMARK 465 TRP B 430
REMARK 465 SER B 431
REMARK 465 GLN B 432
REMARK 465 PRO B 433
REMARK 465 GLN B 434
REMARK 465 PRO B 435
REMARK 465 ALA B 436
REMARK 465 ASP B 437
REMARK 465 ALA B 438
REMARK 465 LEU B 439
REMARK 465 LEU B 440
REMARK 465 GLY B 441
REMARK 465 SER B 442
REMARK 465 LEU B 443
REMARK 465 LEU B 444
REMARK 465 GLY B 445
REMARK 465 LYS B 446
REMARK 465 THR B 447
REMARK 465 ILE B 448
REMARK 465 LEU B 449
REMARK 465 PRO B 450
REMARK 465 GLU B 451
REMARK 465 ALA B 452
REMARK 465 SER B 453
REMARK 465 PHE B 454
REMARK 465 LEU B 455
REMARK 465 ILE B 456
REMARK 465 THR B 457
REMARK 465 ALA B 458
REMARK 465 ARG B 459
REMARK 465 THR B 460
REMARK 465 THR B 461
REMARK 465 ALA B 462
REMARK 465 LEU B 463
REMARK 465 GLN B 464
REMARK 465 ASN B 465
REMARK 465 LEU B 466
REMARK 465 ILE B 467
REMARK 465 PRO B 468
REMARK 465 SER B 469
REMARK 465 LEU B 470
REMARK 465 GLU B 471
REMARK 465 GLN B 472
REMARK 465 ALA B 473
REMARK 465 ARG B 474
REMARK 465 TRP B 475
REMARK 465 VAL B 476
REMARK 465 GLU B 477
REMARK 465 VAL B 478
REMARK 465 LEU B 479
REMARK 465 GLY B 480
REMARK 465 PHE B 481
REMARK 465 SER B 482
REMARK 465 GLU B 483
REMARK 465 SER B 484
REMARK 465 SER B 485
REMARK 465 ARG B 486
REMARK 465 LYS B 487
REMARK 465 GLU B 488
REMARK 465 TYR B 489
REMARK 465 PHE B 490
REMARK 465 TYR B 491
REMARK 465 ARG B 492
REMARK 465 TYR B 493
REMARK 465 PHE B 494
REMARK 465 THR B 495
REMARK 465 ASP B 496
REMARK 465 GLU B 497
REMARK 465 ARG B 498
REMARK 465 GLN B 499
REMARK 465 ALA B 500
REMARK 465 ILE B 501
REMARK 465 ARG B 502
REMARK 465 ALA B 503
REMARK 465 PHE B 504
REMARK 465 ARG B 505
REMARK 465 LEU B 506
REMARK 465 VAL B 507
REMARK 465 LYS B 508
REMARK 465 SER B 509
REMARK 465 ASN B 510
REMARK 465 LYS B 511
REMARK 465 GLU B 512
REMARK 465 LEU B 513
REMARK 465 TRP B 514
REMARK 465 ALA B 515
REMARK 465 LEU B 516
REMARK 465 CYS B 517
REMARK 465 LEU B 518
REMARK 465 VAL B 519
REMARK 465 PRO B 520
REMARK 465 TRP B 521
REMARK 465 VAL B 522
REMARK 465 SER B 523
REMARK 465 TRP B 524
REMARK 465 LEU B 525
REMARK 465 ALA B 526
REMARK 465 CYS B 527
REMARK 465 THR B 528
REMARK 465 CYS B 529
REMARK 465 LEU B 530
REMARK 465 MET B 531
REMARK 465 GLN B 532
REMARK 465 GLN B 533
REMARK 465 MET B 534
REMARK 465 LYS B 535
REMARK 465 ARG B 536
REMARK 465 LYS B 537
REMARK 465 GLU B 538
REMARK 465 LYS B 539
REMARK 465 LEU B 540
REMARK 465 THR B 541
REMARK 465 LEU B 542
REMARK 465 THR B 543
REMARK 465 SER B 544
REMARK 465 LYS B 545
REMARK 465 THR B 546
REMARK 465 THR B 547
REMARK 465 THR B 548
REMARK 465 THR B 549
REMARK 465 LEU B 550
REMARK 465 CYS B 551
REMARK 465 LEU B 552
REMARK 465 HIS B 553
REMARK 465 TYR B 554
REMARK 465 LEU B 555
REMARK 465 ALA B 556
REMARK 465 GLN B 557
REMARK 465 ALA B 558
REMARK 465 LEU B 559
REMARK 465 GLN B 560
REMARK 465 ALA B 561
REMARK 465 GLN B 562
REMARK 465 PRO B 563
REMARK 465 LEU B 564
REMARK 465 GLY B 565
REMARK 465 PRO B 566
REMARK 465 GLN B 567
REMARK 465 LEU B 568
REMARK 465 ARG B 569
REMARK 465 ASP B 570
REMARK 465 LEU B 571
REMARK 465 CYS B 572
REMARK 465 SER B 573
REMARK 465 LEU B 574
REMARK 465 ALA B 575
REMARK 465 ALA B 576
REMARK 465 GLU B 577
REMARK 465 GLY B 578
REMARK 465 ILE B 579
REMARK 465 TRP B 580
REMARK 465 GLN B 581
REMARK 465 LYS B 582
REMARK 465 LYS B 583
REMARK 465 THR B 584
REMARK 465 LEU B 585
REMARK 465 PHE B 586
REMARK 465 SER B 587
REMARK 465 PRO B 588
REMARK 465 ASP B 589
REMARK 465 ASP B 590
REMARK 465 LEU B 591
REMARK 465 ARG B 592
REMARK 465 LYS B 593
REMARK 465 HIS B 594
REMARK 465 GLY B 595
REMARK 465 LEU B 596
REMARK 465 ASP B 597
REMARK 465 GLY B 598
REMARK 465 ALA B 599
REMARK 465 ILE B 600
REMARK 465 ILE B 601
REMARK 465 SER B 602
REMARK 465 THR B 603
REMARK 465 PHE B 604
REMARK 465 LEU B 605
REMARK 465 LYS B 606
REMARK 465 MET B 607
REMARK 465 GLY B 608
REMARK 465 ILE B 609
REMARK 465 LEU B 610
REMARK 465 GLN B 611
REMARK 465 GLU B 612
REMARK 465 HIS B 613
REMARK 465 PRO B 614
REMARK 465 ILE B 615
REMARK 465 PRO B 616
REMARK 465 LEU B 617
REMARK 465 SER B 618
REMARK 465 TYR B 619
REMARK 465 SER B 620
REMARK 465 PHE B 621
REMARK 465 ILE B 622
REMARK 465 HIS B 623
REMARK 465 LEU B 624
REMARK 465 CYS B 625
REMARK 465 PHE B 626
REMARK 465 GLN B 627
REMARK 465 GLU B 628
REMARK 465 PHE B 629
REMARK 465 PHE B 630
REMARK 465 ALA B 631
REMARK 465 ALA B 632
REMARK 465 MET B 633
REMARK 465 SER B 634
REMARK 465 TYR B 635
REMARK 465 VAL B 636
REMARK 465 LEU B 637
REMARK 465 GLU B 638
REMARK 465 ASP B 639
REMARK 465 GLU B 640
REMARK 465 LYS B 641
REMARK 465 GLY B 642
REMARK 465 ARG B 643
REMARK 465 GLY B 644
REMARK 465 LYS B 645
REMARK 465 HIS B 646
REMARK 465 SER B 647
REMARK 465 ASN B 648
REMARK 465 CYS B 649
REMARK 465 ILE B 650
REMARK 465 ILE B 651
REMARK 465 ASP B 652
REMARK 465 LEU B 653
REMARK 465 GLU B 654
REMARK 465 LYS B 655
REMARK 465 THR B 656
REMARK 465 LEU B 657
REMARK 465 GLU B 658
REMARK 465 ALA B 659
REMARK 465 TYR B 660
REMARK 465 GLY B 661
REMARK 465 ILE B 662
REMARK 465 HIS B 663
REMARK 465 GLY B 664
REMARK 465 LEU B 665
REMARK 465 PHE B 666
REMARK 465 GLY B 667
REMARK 465 ALA B 668
REMARK 465 SER B 669
REMARK 465 THR B 670
REMARK 465 THR B 671
REMARK 465 ARG B 672
REMARK 465 PHE B 673
REMARK 465 LEU B 674
REMARK 465 LEU B 675
REMARK 465 GLY B 676
REMARK 465 LEU B 677
REMARK 465 LEU B 678
REMARK 465 SER B 679
REMARK 465 ASP B 680
REMARK 465 GLU B 681
REMARK 465 GLY B 682
REMARK 465 GLU B 683
REMARK 465 ARG B 684
REMARK 465 GLU B 685
REMARK 465 MET B 686
REMARK 465 GLU B 687
REMARK 465 ASN B 688
REMARK 465 ILE B 689
REMARK 465 PHE B 690
REMARK 465 HIS B 691
REMARK 465 CYS B 692
REMARK 465 ARG B 693
REMARK 465 LEU B 694
REMARK 465 SER B 695
REMARK 465 GLN B 696
REMARK 465 GLY B 697
REMARK 465 ARG B 698
REMARK 465 ASN B 699
REMARK 465 LEU B 700
REMARK 465 MET B 701
REMARK 465 GLN B 702
REMARK 465 TRP B 703
REMARK 465 VAL B 704
REMARK 465 PRO B 705
REMARK 465 SER B 706
REMARK 465 LEU B 707
REMARK 465 GLN B 708
REMARK 465 LEU B 709
REMARK 465 LEU B 710
REMARK 465 LEU B 711
REMARK 465 GLN B 712
REMARK 465 PRO B 713
REMARK 465 HIS B 714
REMARK 465 SER B 715
REMARK 465 LEU B 716
REMARK 465 GLU B 717
REMARK 465 SER B 718
REMARK 465 LEU B 719
REMARK 465 HIS B 720
REMARK 465 CYS B 721
REMARK 465 LEU B 722
REMARK 465 TYR B 723
REMARK 465 GLU B 724
REMARK 465 THR B 725
REMARK 465 ARG B 726
REMARK 465 ASN B 727
REMARK 465 LYS B 728
REMARK 465 THR B 729
REMARK 465 PHE B 730
REMARK 465 LEU B 731
REMARK 465 THR B 732
REMARK 465 GLN B 733
REMARK 465 VAL B 734
REMARK 465 MET B 735
REMARK 465 ALA B 736
REMARK 465 HIS B 737
REMARK 465 PHE B 738
REMARK 465 GLU B 739
REMARK 465 GLU B 740
REMARK 465 MET B 741
REMARK 465 GLY B 742
REMARK 465 MET B 743
REMARK 465 CYS B 744
REMARK 465 VAL B 745
REMARK 465 GLU B 746
REMARK 465 THR B 747
REMARK 465 ASP B 748
REMARK 465 MET B 749
REMARK 465 GLU B 750
REMARK 465 LEU B 751
REMARK 465 LEU B 752
REMARK 465 VAL B 753
REMARK 465 CYS B 754
REMARK 465 THR B 755
REMARK 465 PHE B 756
REMARK 465 CYS B 757
REMARK 465 ILE B 758
REMARK 465 LYS B 759
REMARK 465 PHE B 760
REMARK 465 SER B 761
REMARK 465 ARG B 762
REMARK 465 HIS B 763
REMARK 465 VAL B 764
REMARK 465 LYS B 765
REMARK 465 LYS B 766
REMARK 465 LEU B 767
REMARK 465 GLN B 768
REMARK 465 LEU B 769
REMARK 465 ILE B 770
REMARK 465 GLU B 771
REMARK 465 GLY B 772
REMARK 465 ARG B 773
REMARK 465 GLN B 774
REMARK 465 HIS B 775
REMARK 465 ARG B 776
REMARK 465 SER B 777
REMARK 465 THR B 778
REMARK 465 TRP B 779
REMARK 465 SER B 780
REMARK 465 PRO B 781
REMARK 465 THR B 782
REMARK 465 MET B 783
REMARK 465 VAL B 784
REMARK 465 VAL B 785
REMARK 465 LEU B 786
REMARK 465 PHE B 787
REMARK 465 ARG B 788
REMARK 465 TRP B 789
REMARK 465 VAL B 790
REMARK 465 PRO B 791
REMARK 465 VAL B 792
REMARK 465 THR B 793
REMARK 465 ASP B 794
REMARK 465 ALA B 795
REMARK 465 TYR B 796
REMARK 465 TRP B 797
REMARK 465 GLN B 798
REMARK 465 ILE B 799
REMARK 465 LEU B 800
REMARK 465 PHE B 801
REMARK 465 SER B 802
REMARK 465 VAL B 803
REMARK 465 LEU B 804
REMARK 465 LYS B 805
REMARK 465 VAL B 806
REMARK 465 THR B 807
REMARK 465 ARG B 808
REMARK 465 ASN B 809
REMARK 465 LEU B 810
REMARK 465 LYS B 811
REMARK 465 GLU B 812
REMARK 465 LEU B 813
REMARK 465 ASP B 814
REMARK 465 LEU B 815
REMARK 465 SER B 816
REMARK 465 GLY B 817
REMARK 465 ASN B 818
REMARK 465 SER B 819
REMARK 465 LEU B 820
REMARK 465 SER B 821
REMARK 465 HIS B 822
REMARK 465 SER B 823
REMARK 465 ALA B 824
REMARK 465 VAL B 825
REMARK 465 LYS B 826
REMARK 465 SER B 827
REMARK 465 LEU B 828
REMARK 465 CYS B 829
REMARK 465 LYS B 830
REMARK 465 THR B 831
REMARK 465 LEU B 832
REMARK 465 ARG B 833
REMARK 465 ARG B 834
REMARK 465 PRO B 835
REMARK 465 ARG B 836
REMARK 465 CYS B 837
REMARK 465 LEU B 838
REMARK 465 LEU B 839
REMARK 465 GLU B 840
REMARK 465 THR B 841
REMARK 465 LEU B 842
REMARK 465 ARG B 843
REMARK 465 LEU B 844
REMARK 465 ALA B 845
REMARK 465 GLY B 846
REMARK 465 CYS B 847
REMARK 465 GLY B 848
REMARK 465 LEU B 849
REMARK 465 THR B 850
REMARK 465 ALA B 851
REMARK 465 GLU B 852
REMARK 465 ASP B 853
REMARK 465 CYS B 854
REMARK 465 LYS B 855
REMARK 465 ASP B 856
REMARK 465 LEU B 857
REMARK 465 ALA B 858
REMARK 465 PHE B 859
REMARK 465 GLY B 860
REMARK 465 LEU B 861
REMARK 465 ARG B 862
REMARK 465 ALA B 863
REMARK 465 ASN B 864
REMARK 465 GLN B 865
REMARK 465 THR B 866
REMARK 465 LEU B 867
REMARK 465 THR B 868
REMARK 465 GLU B 869
REMARK 465 LEU B 870
REMARK 465 ASP B 871
REMARK 465 LEU B 872
REMARK 465 SER B 873
REMARK 465 PHE B 874
REMARK 465 ASN B 875
REMARK 465 VAL B 876
REMARK 465 LEU B 877
REMARK 465 THR B 878
REMARK 465 ASP B 879
REMARK 465 ALA B 880
REMARK 465 GLY B 881
REMARK 465 ALA B 882
REMARK 465 LYS B 883
REMARK 465 HIS B 884
REMARK 465 LEU B 885
REMARK 465 CYS B 886
REMARK 465 GLN B 887
REMARK 465 ARG B 888
REMARK 465 LEU B 889
REMARK 465 ARG B 890
REMARK 465 GLN B 891
REMARK 465 PRO B 892
REMARK 465 SER B 893
REMARK 465 CYS B 894
REMARK 465 LYS B 895
REMARK 465 LEU B 896
REMARK 465 GLN B 897
REMARK 465 ARG B 898
REMARK 465 LEU B 899
REMARK 465 GLN B 900
REMARK 465 LEU B 901
REMARK 465 VAL B 902
REMARK 465 SER B 903
REMARK 465 CYS B 904
REMARK 465 GLY B 905
REMARK 465 LEU B 906
REMARK 465 THR B 907
REMARK 465 SER B 908
REMARK 465 ASP B 909
REMARK 465 CYS B 910
REMARK 465 CYS B 911
REMARK 465 GLN B 912
REMARK 465 ASP B 913
REMARK 465 LEU B 914
REMARK 465 ALA B 915
REMARK 465 SER B 916
REMARK 465 VAL B 917
REMARK 465 LEU B 918
REMARK 465 SER B 919
REMARK 465 ALA B 920
REMARK 465 SER B 921
REMARK 465 PRO B 922
REMARK 465 SER B 923
REMARK 465 LEU B 924
REMARK 465 LYS B 925
REMARK 465 GLU B 926
REMARK 465 LEU B 927
REMARK 465 ASP B 928
REMARK 465 LEU B 929
REMARK 465 GLN B 930
REMARK 465 GLN B 931
REMARK 465 ASN B 932
REMARK 465 ASN B 933
REMARK 465 LEU B 934
REMARK 465 ASP B 935
REMARK 465 ASP B 936
REMARK 465 VAL B 937
REMARK 465 GLY B 938
REMARK 465 VAL B 939
REMARK 465 ARG B 940
REMARK 465 LEU B 941
REMARK 465 LEU B 942
REMARK 465 CYS B 943
REMARK 465 GLU B 944
REMARK 465 GLY B 945
REMARK 465 LEU B 946
REMARK 465 ARG B 947
REMARK 465 HIS B 948
REMARK 465 PRO B 949
REMARK 465 ALA B 950
REMARK 465 CYS B 951
REMARK 465 LYS B 952
REMARK 465 LEU B 953
REMARK 465 ILE B 954
REMARK 465 ARG B 955
REMARK 465 LEU B 956
REMARK 465 GLY B 957
REMARK 465 LEU B 958
REMARK 465 ASP B 959
REMARK 465 GLN B 960
REMARK 465 THR B 961
REMARK 465 THR B 962
REMARK 465 LEU B 963
REMARK 465 SER B 964
REMARK 465 ASP B 965
REMARK 465 GLU B 966
REMARK 465 MET B 967
REMARK 465 ARG B 968
REMARK 465 GLN B 969
REMARK 465 GLU B 970
REMARK 465 LEU B 971
REMARK 465 ARG B 972
REMARK 465 ALA B 973
REMARK 465 LEU B 974
REMARK 465 GLU B 975
REMARK 465 GLN B 976
REMARK 465 GLU B 977
REMARK 465 LYS B 978
REMARK 465 PRO B 979
REMARK 465 GLN B 980
REMARK 465 LEU B 981
REMARK 465 LEU B 982
REMARK 465 ILE B 983
REMARK 465 PHE B 984
REMARK 465 SER B 985
REMARK 465 ARG B 986
REMARK 465 ARG B 987
REMARK 465 LYS B 988
REMARK 465 PRO B 989
REMARK 465 SER B 990
REMARK 465 VAL B 991
REMARK 465 MET B 992
REMARK 465 THR B 993
REMARK 465 PRO B 994
REMARK 465 THR B 995
REMARK 465 GLU B 996
REMARK 465 GLY B 997
REMARK 465 LEU B 998
REMARK 465 ASP B 999
REMARK 465 THR B 1000
REMARK 465 GLY B 1001
REMARK 465 GLU B 1002
REMARK 465 MET B 1003
REMARK 465 SER B 1004
REMARK 465 ASN B 1005
REMARK 465 SER B 1006
REMARK 465 THR B 1007
REMARK 465 SER B 1008
REMARK 465 SER B 1009
REMARK 465 LEU B 1010
REMARK 465 LYS B 1011
REMARK 465 ARG B 1012
REMARK 465 GLN B 1013
REMARK 465 ARG B 1014
REMARK 465 LEU B 1015
REMARK 465 GLY B 1016
REMARK 465 SER B 1017
REMARK 465 GLU B 1018
REMARK 465 ARG B 1019
REMARK 465 ALA B 1020
REMARK 465 ALA B 1021
REMARK 465 SER B 1022
REMARK 465 HIS B 1023
REMARK 465 VAL B 1024
REMARK 465 ALA B 1025
REMARK 465 GLN B 1026
REMARK 465 ALA B 1027
REMARK 465 ASN B 1028
REMARK 465 LEU B 1029
REMARK 465 LYS B 1030
REMARK 465 LEU B 1031
REMARK 465 LEU B 1032
REMARK 465 ASP B 1033
REMARK 465 VAL B 1034
REMARK 465 SER B 1035
REMARK 465 LYS B 1036
REMARK 465 ILE B 1037
REMARK 465 PHE B 1038
REMARK 465 PRO B 1039
REMARK 465 ILE B 1040
REMARK 465 ALA B 1041
REMARK 465 GLU B 1042
REMARK 465 ILE B 1043
REMARK 465 ALA B 1044
REMARK 465 GLU B 1045
REMARK 465 GLU B 1046
REMARK 465 SER B 1047
REMARK 465 SER B 1048
REMARK 465 PRO B 1049
REMARK 465 GLU B 1050
REMARK 465 VAL B 1051
REMARK 465 VAL B 1052
REMARK 465 PRO B 1053
REMARK 465 VAL B 1054
REMARK 465 GLU B 1055
REMARK 465 LEU B 1056
REMARK 465 LEU B 1057
REMARK 465 CYS B 1058
REMARK 465 VAL B 1059
REMARK 465 PRO B 1060
REMARK 465 SER B 1061
REMARK 465 PRO B 1062
REMARK 465 ALA B 1063
REMARK 465 SER B 1064
REMARK 465 GLN B 1065
REMARK 465 GLY B 1066
REMARK 465 ASP B 1067
REMARK 465 LEU B 1068
REMARK 465 HIS B 1069
REMARK 465 THR B 1070
REMARK 465 LYS B 1071
REMARK 465 PRO B 1072
REMARK 465 LEU B 1073
REMARK 465 GLY B 1074
REMARK 465 THR B 1075
REMARK 465 ASP B 1076
REMARK 465 ASP B 1077
REMARK 465 ASP B 1078
REMARK 465 LYS G 1351
REMARK 465 PRO G 1352
REMARK 465 GLY G 1353
REMARK 465 ASP G 1354
REMARK 465 LEU G 1355
REMARK 465 MET G 1356
REMARK 465 PRO G 1357
REMARK 465 ALA G 1358
REMARK 465 THR G 1359
REMARK 465 THR G 1360
REMARK 465 LEU G 1361
REMARK 465 ILE G 1362
REMARK 465 PRO G 1363
REMARK 465 PRO G 1364
REMARK 465 ALA G 1365
REMARK 465 ARG G 1366
REMARK 465 ILE G 1367
REMARK 465 ALA G 1368
REMARK 465 VAL G 1369
REMARK 465 PRO G 1370
REMARK 465 SER G 1371
REMARK 465 PRO G 1372
REMARK 465 LEU G 1373
REMARK 465 ASP G 1374
REMARK 465 ALA G 1375
REMARK 465 PRO G 1376
REMARK 465 GLN G 1377
REMARK 465 LEU G 1378
REMARK 465 LEU G 1379
REMARK 465 HIS G 1380
REMARK 465 PHE G 1381
REMARK 465 VAL G 1382
REMARK 465 ASP G 1383
REMARK 465 GLN G 1384
REMARK 465 TYR G 1385
REMARK 465 ARG G 1386
REMARK 465 GLU G 1387
REMARK 465 GLN G 1388
REMARK 465 LEU G 1389
REMARK 465 ILE G 1390
REMARK 465 ALA G 1391
REMARK 465 ARG G 1392
REMARK 465 VAL G 1393
REMARK 465 THR G 1394
REMARK 465 SER G 1395
REMARK 465 VAL G 1396
REMARK 465 GLU G 1397
REMARK 465 VAL G 1398
REMARK 465 VAL G 1399
REMARK 465 LEU G 1400
REMARK 465 ASP G 1401
REMARK 465 LYS G 1402
REMARK 465 LEU G 1403
REMARK 465 HIS G 1404
REMARK 465 GLY G 1405
REMARK 465 GLN G 1406
REMARK 465 VAL G 1407
REMARK 465 LEU G 1408
REMARK 465 SER G 1409
REMARK 465 GLN G 1410
REMARK 465 GLU G 1411
REMARK 465 GLN G 1412
REMARK 465 TYR G 1413
REMARK 465 GLU G 1414
REMARK 465 ARG G 1415
REMARK 465 VAL G 1416
REMARK 465 LEU G 1417
REMARK 465 ALA G 1418
REMARK 465 GLU G 1419
REMARK 465 ASN G 1420
REMARK 465 THR G 1421
REMARK 465 ARG G 1422
REMARK 465 PRO G 1423
REMARK 465 SER G 1424
REMARK 465 GLN G 1425
REMARK 465 MET G 1426
REMARK 465 ARG G 1427
REMARK 465 LYS G 1428
REMARK 465 LEU G 1429
REMARK 465 PHE G 1430
REMARK 465 SER G 1431
REMARK 465 LEU G 1432
REMARK 465 SER G 1433
REMARK 465 GLN G 1434
REMARK 465 SER G 1435
REMARK 465 TRP G 1436
REMARK 465 ASP G 1437
REMARK 465 ARG G 1438
REMARK 465 LYS G 1439
REMARK 465 CYS G 1440
REMARK 465 LYS G 1441
REMARK 465 ASP G 1442
REMARK 465 GLY G 1443
REMARK 465 LEU G 1444
REMARK 465 TYR G 1445
REMARK 465 GLN G 1446
REMARK 465 ALA G 1447
REMARK 465 LEU G 1448
REMARK 465 LYS G 1449
REMARK 465 GLU G 1450
REMARK 465 THR G 1451
REMARK 465 HIS G 1452
REMARK 465 PRO G 1453
REMARK 465 HIS G 1454
REMARK 465 LEU G 1455
REMARK 465 ILE G 1456
REMARK 465 MET G 1457
REMARK 465 GLU G 1458
REMARK 465 LEU G 1459
REMARK 465 TRP G 1460
REMARK 465 GLU G 1461
REMARK 465 LYS G 1462
REMARK 465 GLY G 1463
REMARK 465 SER G 1464
REMARK 465 LYS G 1465
REMARK 465 LYS G 1466
REMARK 465 GLY G 1467
REMARK 465 LEU G 1468
REMARK 465 LEU G 1469
REMARK 465 PRO G 1470
REMARK 465 LEU G 1471
REMARK 465 SER G 1472
REMARK 465 SER G 1473
REMARK 465 PRO C 1357
REMARK 465 ALA C 1358
REMARK 465 THR C 1359
REMARK 465 THR C 1360
REMARK 465 LEU C 1361
REMARK 465 ILE C 1362
REMARK 465 PRO C 1363
REMARK 465 PRO C 1364
REMARK 465 ALA C 1365
REMARK 465 ARG C 1366
REMARK 465 ILE C 1367
REMARK 465 ALA C 1368
REMARK 465 VAL C 1369
REMARK 465 PRO C 1370
REMARK 465 SER C 1371
REMARK 465 PRO C 1372
REMARK 465 LEU C 1373
REMARK 465 ASP C 1374
REMARK 465 ALA C 1375
REMARK 465 PRO C 1376
REMARK 465 GLN C 1377
REMARK 465 LEU C 1378
REMARK 465 LEU C 1379
REMARK 465 HIS C 1380
REMARK 465 PHE C 1381
REMARK 465 VAL C 1382
REMARK 465 ASP C 1383
REMARK 465 GLN C 1384
REMARK 465 TYR C 1385
REMARK 465 ARG C 1386
REMARK 465 GLU C 1387
REMARK 465 GLN C 1388
REMARK 465 LEU C 1389
REMARK 465 ILE C 1390
REMARK 465 ALA C 1391
REMARK 465 ARG C 1392
REMARK 465 VAL C 1393
REMARK 465 THR C 1394
REMARK 465 SER C 1395
REMARK 465 VAL C 1396
REMARK 465 GLU C 1397
REMARK 465 VAL C 1398
REMARK 465 VAL C 1399
REMARK 465 LEU C 1400
REMARK 465 ASP C 1401
REMARK 465 LYS C 1402
REMARK 465 LEU C 1403
REMARK 465 HIS C 1404
REMARK 465 GLY C 1405
REMARK 465 GLN C 1406
REMARK 465 VAL C 1407
REMARK 465 LEU C 1408
REMARK 465 SER C 1409
REMARK 465 GLN C 1410
REMARK 465 GLU C 1411
REMARK 465 GLN C 1412
REMARK 465 TYR C 1413
REMARK 465 GLU C 1414
REMARK 465 ARG C 1415
REMARK 465 VAL C 1416
REMARK 465 LEU C 1417
REMARK 465 ALA C 1418
REMARK 465 GLU C 1419
REMARK 465 ASN C 1420
REMARK 465 THR C 1421
REMARK 465 ARG C 1422
REMARK 465 PRO C 1423
REMARK 465 SER C 1424
REMARK 465 GLN C 1425
REMARK 465 MET C 1426
REMARK 465 ARG C 1427
REMARK 465 LYS C 1428
REMARK 465 LEU C 1429
REMARK 465 PHE C 1430
REMARK 465 SER C 1431
REMARK 465 LEU C 1432
REMARK 465 SER C 1433
REMARK 465 GLN C 1434
REMARK 465 SER C 1435
REMARK 465 TRP C 1436
REMARK 465 ASP C 1437
REMARK 465 ARG C 1438
REMARK 465 LYS C 1439
REMARK 465 CYS C 1440
REMARK 465 LYS C 1441
REMARK 465 ASP C 1442
REMARK 465 GLY C 1443
REMARK 465 LEU C 1444
REMARK 465 TYR C 1445
REMARK 465 GLN C 1446
REMARK 465 ALA C 1447
REMARK 465 LEU C 1448
REMARK 465 LYS C 1449
REMARK 465 GLU C 1450
REMARK 465 THR C 1451
REMARK 465 HIS C 1452
REMARK 465 PRO C 1453
REMARK 465 HIS C 1454
REMARK 465 LEU C 1455
REMARK 465 ILE C 1456
REMARK 465 MET C 1457
REMARK 465 GLU C 1458
REMARK 465 LEU C 1459
REMARK 465 TRP C 1460
REMARK 465 GLU C 1461
REMARK 465 LYS C 1462
REMARK 465 GLY C 1463
REMARK 465 SER C 1464
REMARK 465 LYS C 1465
REMARK 465 LYS C 1466
REMARK 465 GLY C 1467
REMARK 465 LEU C 1468
REMARK 465 LEU C 1469
REMARK 465 PRO C 1470
REMARK 465 LEU C 1471
REMARK 465 SER C 1472
REMARK 465 SER C 1473
REMARK 465 MET D 1
REMARK 465 ALA D 2
REMARK 465 THR D 3
REMARK 465 THR D 4
REMARK 465 GLY D 5
REMARK 465 THR D 6
REMARK 465 PRO D 7
REMARK 465 THR D 8
REMARK 465 ALA D 9
REMARK 465 ASP D 10
REMARK 465 ARG D 11
REMARK 465 GLY D 12
REMARK 465 ASP D 13
REMARK 465 ALA D 14
REMARK 465 ALA D 15
REMARK 465 ALA D 16
REMARK 465 THR D 17
REMARK 465 MET E 1
REMARK 465 ALA E 2
REMARK 465 GLY E 3
REMARK 465 GLY E 4
REMARK 465 ALA E 5
REMARK 465 TRP E 6
REMARK 465 GLY E 7
REMARK 465 ARG E 8
REMARK 465 LEU E 9
REMARK 465 ALA E 10
REMARK 465 CYS E 11
REMARK 465 TYR E 12
REMARK 465 LEU E 13
REMARK 465 GLU E 14
REMARK 465 PHE E 15
REMARK 465 LEU E 16
REMARK 465 LYS E 17
REMARK 465 LYS E 18
REMARK 465 GLU E 19
REMARK 465 GLU E 20
REMARK 465 LEU E 21
REMARK 465 LYS E 22
REMARK 465 GLU E 23
REMARK 465 PHE E 24
REMARK 465 GLN E 25
REMARK 465 LEU E 26
REMARK 465 LEU E 27
REMARK 465 LEU E 28
REMARK 465 ALA E 29
REMARK 465 ASN E 30
REMARK 465 LYS E 31
REMARK 465 ALA E 32
REMARK 465 HIS E 33
REMARK 465 SER E 34
REMARK 465 ARG E 35
REMARK 465 SER E 36
REMARK 465 SER E 37
REMARK 465 SER E 38
REMARK 465 GLY E 39
REMARK 465 GLU E 40
REMARK 465 THR E 41
REMARK 465 PRO E 42
REMARK 465 ALA E 43
REMARK 465 GLN E 44
REMARK 465 PRO E 45
REMARK 465 GLU E 46
REMARK 465 LYS E 47
REMARK 465 THR E 48
REMARK 465 SER E 49
REMARK 465 GLY E 50
REMARK 465 MET E 51
REMARK 465 GLU E 52
REMARK 465 VAL E 53
REMARK 465 ALA E 54
REMARK 465 SER E 55
REMARK 465 TYR E 56
REMARK 465 LEU E 57
REMARK 465 VAL E 58
REMARK 465 ALA E 59
REMARK 465 GLN E 60
REMARK 465 TYR E 61
REMARK 465 GLY E 62
REMARK 465 GLU E 63
REMARK 465 GLN E 64
REMARK 465 ARG E 65
REMARK 465 ALA E 66
REMARK 465 TRP E 67
REMARK 465 ASP E 68
REMARK 465 LEU E 69
REMARK 465 ALA E 70
REMARK 465 LEU E 71
REMARK 465 HIS E 72
REMARK 465 THR E 73
REMARK 465 TRP E 74
REMARK 465 GLU E 75
REMARK 465 GLN E 76
REMARK 465 MET E 77
REMARK 465 GLY E 78
REMARK 465 LEU E 79
REMARK 465 ARG E 80
REMARK 465 SER E 81
REMARK 465 LEU E 82
REMARK 465 CYS E 83
REMARK 465 ALA E 84
REMARK 465 GLN E 85
REMARK 465 ALA E 86
REMARK 465 GLN E 87
REMARK 465 GLU E 88
REMARK 465 GLY E 89
REMARK 465 ALA E 90
REMARK 465 GLY E 91
REMARK 465 HIS E 92
REMARK 465 SER E 93
REMARK 465 PRO E 94
REMARK 465 SER E 95
REMARK 465 PHE E 96
REMARK 465 PRO E 97
REMARK 465 TYR E 98
REMARK 465 SER E 99
REMARK 465 PRO E 100
REMARK 465 SER E 101
REMARK 465 GLU E 102
REMARK 465 PRO E 103
REMARK 465 HIS E 104
REMARK 465 LEU E 105
REMARK 465 GLY E 106
REMARK 465 SER E 107
REMARK 465 PRO E 108
REMARK 465 SER E 109
REMARK 465 GLN E 110
REMARK 465 PRO E 111
REMARK 465 THR E 112
REMARK 465 SER E 113
REMARK 465 THR E 114
REMARK 465 ALA E 115
REMARK 465 VAL E 116
REMARK 465 LEU E 117
REMARK 465 MET E 118
REMARK 465 PRO E 119
REMARK 465 TRP E 120
REMARK 465 ILE E 121
REMARK 465 HIS E 122
REMARK 465 GLU E 123
REMARK 465 LEU E 124
REMARK 465 PRO E 125
REMARK 465 ALA E 126
REMARK 465 GLY E 127
REMARK 465 CYS E 128
REMARK 465 THR E 129
REMARK 465 GLN E 130
REMARK 465 GLY E 131
REMARK 465 SER E 132
REMARK 465 GLU E 133
REMARK 465 ARG E 134
REMARK 465 ARG E 135
REMARK 465 VAL E 136
REMARK 465 LEU E 137
REMARK 465 ARG E 138
REMARK 465 GLN E 139
REMARK 465 LEU E 140
REMARK 465 PRO E 141
REMARK 465 ASP E 142
REMARK 465 THR E 143
REMARK 465 SER E 144
REMARK 465 GLY E 145
REMARK 465 ARG E 146
REMARK 465 ARG E 147
REMARK 465 TRP E 148
REMARK 465 ARG E 149
REMARK 465 GLU E 150
REMARK 465 ILE E 151
REMARK 465 SER E 152
REMARK 465 ALA E 153
REMARK 465 SER E 154
REMARK 465 LEU E 155
REMARK 465 LEU E 156
REMARK 465 TYR E 157
REMARK 465 GLN E 158
REMARK 465 ALA E 159
REMARK 465 LEU E 160
REMARK 465 PRO E 161
REMARK 465 SER E 162
REMARK 465 SER E 163
REMARK 465 PRO E 164
REMARK 465 ASP E 165
REMARK 465 HIS E 166
REMARK 465 GLU E 167
REMARK 465 SER E 168
REMARK 465 PRO E 169
REMARK 465 SER E 170
REMARK 465 GLN E 171
REMARK 465 GLU E 172
REMARK 465 SER E 173
REMARK 465 PRO E 174
REMARK 465 ASN E 175
REMARK 465 ALA E 176
REMARK 465 PRO E 177
REMARK 465 THR E 178
REMARK 465 SER E 179
REMARK 465 THR E 180
REMARK 465 ALA E 181
REMARK 465 VAL E 182
REMARK 465 LEU E 183
REMARK 465 GLY E 184
REMARK 465 SER E 185
REMARK 465 TRP E 186
REMARK 465 GLY E 187
REMARK 465 SER E 188
REMARK 465 PRO E 189
REMARK 465 PRO E 190
REMARK 465 GLN E 191
REMARK 465 PRO E 192
REMARK 465 SER E 193
REMARK 465 LEU E 194
REMARK 465 ALA E 195
REMARK 465 PRO E 196
REMARK 465 ARG E 197
REMARK 465 GLU E 198
REMARK 465 GLN E 199
REMARK 465 GLU E 200
REMARK 465 ALA E 201
REMARK 465 PRO E 202
REMARK 465 GLY E 203
REMARK 465 THR E 204
REMARK 465 GLN E 205
REMARK 465 TRP E 206
REMARK 465 PRO E 207
REMARK 465 LEU E 208
REMARK 465 ASP E 209
REMARK 465 GLU E 210
REMARK 465 THR E 211
REMARK 465 SER E 212
REMARK 465 GLY E 213
REMARK 465 ILE E 214
REMARK 465 TYR E 215
REMARK 465 TYR E 216
REMARK 465 THR E 217
REMARK 465 GLU E 218
REMARK 465 ILE E 219
REMARK 465 ARG E 220
REMARK 465 GLU E 221
REMARK 465 ARG E 222
REMARK 465 GLU E 223
REMARK 465 ARG E 224
REMARK 465 GLU E 225
REMARK 465 LYS E 226
REMARK 465 SER E 227
REMARK 465 GLU E 228
REMARK 465 LYS E 229
REMARK 465 GLY E 230
REMARK 465 ARG E 231
REMARK 465 PRO E 232
REMARK 465 PRO E 233
REMARK 465 TRP E 234
REMARK 465 ALA E 235
REMARK 465 ALA E 236
REMARK 465 VAL E 237
REMARK 465 VAL E 238
REMARK 465 GLY E 239
REMARK 465 THR E 240
REMARK 465 PRO E 241
REMARK 465 PRO E 242
REMARK 465 GLN E 243
REMARK 465 ALA E 244
REMARK 465 HIS E 245
REMARK 465 THR E 246
REMARK 465 SER E 247
REMARK 465 LEU E 248
REMARK 465 GLN E 249
REMARK 465 PRO E 250
REMARK 465 HIS E 251
REMARK 465 HIS E 252
REMARK 465 HIS E 253
REMARK 465 PRO E 254
REMARK 465 TRP E 255
REMARK 465 GLU E 256
REMARK 465 PRO E 257
REMARK 465 SER E 258
REMARK 465 VAL E 259
REMARK 465 ARG E 260
REMARK 465 GLU E 261
REMARK 465 SER E 262
REMARK 465 LEU E 263
REMARK 465 CYS E 264
REMARK 465 SER E 265
REMARK 465 THR E 266
REMARK 465 TRP E 267
REMARK 465 PRO E 268
REMARK 465 TRP E 269
REMARK 465 LYS E 270
REMARK 465 ASN E 271
REMARK 465 GLU E 272
REMARK 465 ASP E 273
REMARK 465 PHE E 274
REMARK 465 ASN E 275
REMARK 465 GLN E 276
REMARK 465 LYS E 277
REMARK 465 PHE E 278
REMARK 465 THR E 279
REMARK 465 GLN E 280
REMARK 465 LEU E 281
REMARK 465 LEU E 282
REMARK 465 LEU E 283
REMARK 465 LEU E 284
REMARK 465 GLN E 285
REMARK 465 ARG E 286
REMARK 465 PRO E 287
REMARK 465 HIS E 288
REMARK 465 PRO E 289
REMARK 465 ARG E 290
REMARK 465 SER E 291
REMARK 465 GLN E 292
REMARK 465 ASP E 293
REMARK 465 PRO E 294
REMARK 465 LEU E 295
REMARK 465 VAL E 296
REMARK 465 LYS E 297
REMARK 465 ARG E 298
REMARK 465 SER E 299
REMARK 465 TRP E 300
REMARK 465 PRO E 301
REMARK 465 ASP E 302
REMARK 465 TYR E 303
REMARK 465 VAL E 304
REMARK 465 GLU E 305
REMARK 465 GLU E 306
REMARK 465 ASN E 307
REMARK 465 ARG E 308
REMARK 465 GLY E 309
REMARK 465 HIS E 310
REMARK 465 LEU E 311
REMARK 465 ILE E 312
REMARK 465 GLU E 313
REMARK 465 ILE E 314
REMARK 465 ARG E 315
REMARK 465 ASP E 316
REMARK 465 LEU E 317
REMARK 465 PHE E 318
REMARK 465 GLY E 319
REMARK 465 PRO E 320
REMARK 465 GLY E 321
REMARK 465 LEU E 322
REMARK 465 ASP E 323
REMARK 465 THR E 324
REMARK 465 GLN E 325
REMARK 465 GLU E 326
REMARK 465 PRO E 327
REMARK 465 ARG E 328
REMARK 465 ILE E 329
REMARK 465 VAL E 330
REMARK 465 ILE E 331
REMARK 465 LEU E 332
REMARK 465 GLN E 333
REMARK 465 GLY E 334
REMARK 465 ALA E 335
REMARK 465 ALA E 336
REMARK 465 GLY E 337
REMARK 465 ILE E 338
REMARK 465 GLY E 339
REMARK 465 LYS E 340
REMARK 465 SER E 341
REMARK 465 THR E 342
REMARK 465 LEU E 343
REMARK 465 ALA E 344
REMARK 465 ARG E 345
REMARK 465 GLN E 346
REMARK 465 VAL E 347
REMARK 465 LYS E 348
REMARK 465 GLU E 349
REMARK 465 ALA E 350
REMARK 465 TRP E 351
REMARK 465 GLY E 352
REMARK 465 ARG E 353
REMARK 465 GLY E 354
REMARK 465 GLN E 355
REMARK 465 LEU E 356
REMARK 465 TYR E 357
REMARK 465 GLY E 358
REMARK 465 ASP E 359
REMARK 465 ARG E 360
REMARK 465 PHE E 361
REMARK 465 GLN E 362
REMARK 465 HIS E 363
REMARK 465 VAL E 364
REMARK 465 PHE E 365
REMARK 465 TYR E 366
REMARK 465 PHE E 367
REMARK 465 SER E 368
REMARK 465 CYS E 369
REMARK 465 ARG E 370
REMARK 465 GLU E 371
REMARK 465 LEU E 372
REMARK 465 ALA E 373
REMARK 465 GLN E 374
REMARK 465 SER E 375
REMARK 465 LYS E 376
REMARK 465 VAL E 377
REMARK 465 VAL E 378
REMARK 465 SER E 379
REMARK 465 LEU E 380
REMARK 465 ALA E 381
REMARK 465 GLU E 382
REMARK 465 LEU E 383
REMARK 465 ILE E 384
REMARK 465 GLY E 385
REMARK 465 LYS E 386
REMARK 465 ASP E 387
REMARK 465 GLY E 388
REMARK 465 THR E 389
REMARK 465 ALA E 390
REMARK 465 THR E 391
REMARK 465 PRO E 392
REMARK 465 ALA E 393
REMARK 465 PRO E 394
REMARK 465 ILE E 395
REMARK 465 ARG E 396
REMARK 465 GLN E 397
REMARK 465 ILE E 398
REMARK 465 LEU E 399
REMARK 465 SER E 400
REMARK 465 ARG E 401
REMARK 465 PRO E 402
REMARK 465 GLU E 403
REMARK 465 ARG E 404
REMARK 465 LEU E 405
REMARK 465 LEU E 406
REMARK 465 PHE E 407
REMARK 465 ILE E 408
REMARK 465 LEU E 409
REMARK 465 ASP E 410
REMARK 465 GLY E 411
REMARK 465 VAL E 412
REMARK 465 ASP E 413
REMARK 465 GLU E 414
REMARK 465 PRO E 415
REMARK 465 GLY E 416
REMARK 465 TRP E 417
REMARK 465 VAL E 418
REMARK 465 LEU E 419
REMARK 465 GLN E 420
REMARK 465 GLU E 421
REMARK 465 PRO E 422
REMARK 465 SER E 423
REMARK 465 SER E 424
REMARK 465 GLU E 425
REMARK 465 LEU E 426
REMARK 465 CYS E 427
REMARK 465 LEU E 428
REMARK 465 HIS E 429
REMARK 465 TRP E 430
REMARK 465 SER E 431
REMARK 465 GLN E 432
REMARK 465 PRO E 433
REMARK 465 GLN E 434
REMARK 465 PRO E 435
REMARK 465 ALA E 436
REMARK 465 ASP E 437
REMARK 465 ALA E 438
REMARK 465 LEU E 439
REMARK 465 LEU E 440
REMARK 465 GLY E 441
REMARK 465 SER E 442
REMARK 465 LEU E 443
REMARK 465 LEU E 444
REMARK 465 GLY E 445
REMARK 465 LYS E 446
REMARK 465 THR E 447
REMARK 465 ILE E 448
REMARK 465 LEU E 449
REMARK 465 PRO E 450
REMARK 465 GLU E 451
REMARK 465 ALA E 452
REMARK 465 SER E 453
REMARK 465 PHE E 454
REMARK 465 LEU E 455
REMARK 465 ILE E 456
REMARK 465 THR E 457
REMARK 465 ALA E 458
REMARK 465 ARG E 459
REMARK 465 THR E 460
REMARK 465 THR E 461
REMARK 465 ALA E 462
REMARK 465 LEU E 463
REMARK 465 GLN E 464
REMARK 465 ASN E 465
REMARK 465 LEU E 466
REMARK 465 ILE E 467
REMARK 465 PRO E 468
REMARK 465 SER E 469
REMARK 465 LEU E 470
REMARK 465 GLU E 471
REMARK 465 GLN E 472
REMARK 465 ALA E 473
REMARK 465 ARG E 474
REMARK 465 TRP E 475
REMARK 465 VAL E 476
REMARK 465 GLU E 477
REMARK 465 VAL E 478
REMARK 465 LEU E 479
REMARK 465 GLY E 480
REMARK 465 PHE E 481
REMARK 465 SER E 482
REMARK 465 GLU E 483
REMARK 465 SER E 484
REMARK 465 SER E 485
REMARK 465 ARG E 486
REMARK 465 LYS E 487
REMARK 465 GLU E 488
REMARK 465 TYR E 489
REMARK 465 PHE E 490
REMARK 465 TYR E 491
REMARK 465 ARG E 492
REMARK 465 TYR E 493
REMARK 465 PHE E 494
REMARK 465 THR E 495
REMARK 465 ASP E 496
REMARK 465 GLU E 497
REMARK 465 ARG E 498
REMARK 465 GLN E 499
REMARK 465 ALA E 500
REMARK 465 ILE E 501
REMARK 465 ARG E 502
REMARK 465 ALA E 503
REMARK 465 PHE E 504
REMARK 465 ARG E 505
REMARK 465 LEU E 506
REMARK 465 VAL E 507
REMARK 465 LYS E 508
REMARK 465 SER E 509
REMARK 465 ASN E 510
REMARK 465 LYS E 511
REMARK 465 GLU E 512
REMARK 465 LEU E 513
REMARK 465 TRP E 514
REMARK 465 ALA E 515
REMARK 465 LEU E 516
REMARK 465 CYS E 517
REMARK 465 LEU E 518
REMARK 465 VAL E 519
REMARK 465 PRO E 520
REMARK 465 TRP E 521
REMARK 465 VAL E 522
REMARK 465 SER E 523
REMARK 465 TRP E 524
REMARK 465 LEU E 525
REMARK 465 ALA E 526
REMARK 465 CYS E 527
REMARK 465 THR E 528
REMARK 465 CYS E 529
REMARK 465 LEU E 530
REMARK 465 MET E 531
REMARK 465 GLN E 532
REMARK 465 GLN E 533
REMARK 465 MET E 534
REMARK 465 LYS E 535
REMARK 465 ARG E 536
REMARK 465 LYS E 537
REMARK 465 GLU E 538
REMARK 465 LYS E 539
REMARK 465 LEU E 540
REMARK 465 THR E 541
REMARK 465 LEU E 542
REMARK 465 THR E 543
REMARK 465 SER E 544
REMARK 465 LYS E 545
REMARK 465 THR E 546
REMARK 465 THR E 547
REMARK 465 THR E 548
REMARK 465 THR E 549
REMARK 465 LEU E 550
REMARK 465 CYS E 551
REMARK 465 LEU E 552
REMARK 465 HIS E 553
REMARK 465 TYR E 554
REMARK 465 LEU E 555
REMARK 465 ALA E 556
REMARK 465 GLN E 557
REMARK 465 ALA E 558
REMARK 465 LEU E 559
REMARK 465 GLN E 560
REMARK 465 ALA E 561
REMARK 465 GLN E 562
REMARK 465 PRO E 563
REMARK 465 LEU E 564
REMARK 465 GLY E 565
REMARK 465 PRO E 566
REMARK 465 GLN E 567
REMARK 465 LEU E 568
REMARK 465 ARG E 569
REMARK 465 ASP E 570
REMARK 465 LEU E 571
REMARK 465 CYS E 572
REMARK 465 SER E 573
REMARK 465 LEU E 574
REMARK 465 ALA E 575
REMARK 465 ALA E 576
REMARK 465 GLU E 577
REMARK 465 GLY E 578
REMARK 465 ILE E 579
REMARK 465 TRP E 580
REMARK 465 GLN E 581
REMARK 465 LYS E 582
REMARK 465 LYS E 583
REMARK 465 THR E 584
REMARK 465 LEU E 585
REMARK 465 PHE E 586
REMARK 465 SER E 587
REMARK 465 PRO E 588
REMARK 465 ASP E 589
REMARK 465 ASP E 590
REMARK 465 LEU E 591
REMARK 465 ARG E 592
REMARK 465 LYS E 593
REMARK 465 HIS E 594
REMARK 465 GLY E 595
REMARK 465 LEU E 596
REMARK 465 ASP E 597
REMARK 465 GLY E 598
REMARK 465 ALA E 599
REMARK 465 ILE E 600
REMARK 465 ILE E 601
REMARK 465 SER E 602
REMARK 465 THR E 603
REMARK 465 PHE E 604
REMARK 465 LEU E 605
REMARK 465 LYS E 606
REMARK 465 MET E 607
REMARK 465 GLY E 608
REMARK 465 ILE E 609
REMARK 465 LEU E 610
REMARK 465 GLN E 611
REMARK 465 GLU E 612
REMARK 465 HIS E 613
REMARK 465 PRO E 614
REMARK 465 ILE E 615
REMARK 465 PRO E 616
REMARK 465 LEU E 617
REMARK 465 SER E 618
REMARK 465 TYR E 619
REMARK 465 SER E 620
REMARK 465 PHE E 621
REMARK 465 ILE E 622
REMARK 465 HIS E 623
REMARK 465 LEU E 624
REMARK 465 CYS E 625
REMARK 465 PHE E 626
REMARK 465 GLN E 627
REMARK 465 GLU E 628
REMARK 465 PHE E 629
REMARK 465 PHE E 630
REMARK 465 ALA E 631
REMARK 465 ALA E 632
REMARK 465 MET E 633
REMARK 465 SER E 634
REMARK 465 TYR E 635
REMARK 465 VAL E 636
REMARK 465 LEU E 637
REMARK 465 GLU E 638
REMARK 465 ASP E 639
REMARK 465 GLU E 640
REMARK 465 LYS E 641
REMARK 465 GLY E 642
REMARK 465 ARG E 643
REMARK 465 GLY E 644
REMARK 465 LYS E 645
REMARK 465 HIS E 646
REMARK 465 SER E 647
REMARK 465 ASN E 648
REMARK 465 CYS E 649
REMARK 465 ILE E 650
REMARK 465 ILE E 651
REMARK 465 ASP E 652
REMARK 465 LEU E 653
REMARK 465 GLU E 654
REMARK 465 LYS E 655
REMARK 465 THR E 656
REMARK 465 LEU E 657
REMARK 465 GLU E 658
REMARK 465 ALA E 659
REMARK 465 TYR E 660
REMARK 465 GLY E 661
REMARK 465 ILE E 662
REMARK 465 HIS E 663
REMARK 465 GLY E 664
REMARK 465 LEU E 665
REMARK 465 PHE E 666
REMARK 465 GLY E 667
REMARK 465 ALA E 668
REMARK 465 SER E 669
REMARK 465 THR E 670
REMARK 465 THR E 671
REMARK 465 ARG E 672
REMARK 465 PHE E 673
REMARK 465 LEU E 674
REMARK 465 LEU E 675
REMARK 465 GLY E 676
REMARK 465 LEU E 677
REMARK 465 LEU E 678
REMARK 465 SER E 679
REMARK 465 ASP E 680
REMARK 465 GLU E 681
REMARK 465 GLY E 682
REMARK 465 GLU E 683
REMARK 465 ARG E 684
REMARK 465 GLU E 685
REMARK 465 MET E 686
REMARK 465 GLU E 687
REMARK 465 ASN E 688
REMARK 465 ILE E 689
REMARK 465 PHE E 690
REMARK 465 HIS E 691
REMARK 465 CYS E 692
REMARK 465 ARG E 693
REMARK 465 LEU E 694
REMARK 465 SER E 695
REMARK 465 GLN E 696
REMARK 465 GLY E 697
REMARK 465 ARG E 698
REMARK 465 ASN E 699
REMARK 465 LEU E 700
REMARK 465 MET E 701
REMARK 465 GLN E 702
REMARK 465 TRP E 703
REMARK 465 VAL E 704
REMARK 465 PRO E 705
REMARK 465 SER E 706
REMARK 465 LEU E 707
REMARK 465 GLN E 708
REMARK 465 LEU E 709
REMARK 465 LEU E 710
REMARK 465 LEU E 711
REMARK 465 GLN E 712
REMARK 465 PRO E 713
REMARK 465 HIS E 714
REMARK 465 SER E 715
REMARK 465 LEU E 716
REMARK 465 GLU E 717
REMARK 465 SER E 718
REMARK 465 LEU E 719
REMARK 465 HIS E 720
REMARK 465 CYS E 721
REMARK 465 LEU E 722
REMARK 465 TYR E 723
REMARK 465 GLU E 724
REMARK 465 THR E 725
REMARK 465 ARG E 726
REMARK 465 ASN E 727
REMARK 465 LYS E 728
REMARK 465 THR E 729
REMARK 465 PHE E 730
REMARK 465 LEU E 731
REMARK 465 THR E 732
REMARK 465 GLN E 733
REMARK 465 VAL E 734
REMARK 465 MET E 735
REMARK 465 ALA E 736
REMARK 465 HIS E 737
REMARK 465 PHE E 738
REMARK 465 GLU E 739
REMARK 465 GLU E 740
REMARK 465 MET E 741
REMARK 465 GLY E 742
REMARK 465 MET E 743
REMARK 465 CYS E 744
REMARK 465 VAL E 745
REMARK 465 GLU E 746
REMARK 465 THR E 747
REMARK 465 ASP E 748
REMARK 465 MET E 749
REMARK 465 GLU E 750
REMARK 465 LEU E 751
REMARK 465 LEU E 752
REMARK 465 VAL E 753
REMARK 465 CYS E 754
REMARK 465 THR E 755
REMARK 465 PHE E 756
REMARK 465 CYS E 757
REMARK 465 ILE E 758
REMARK 465 LYS E 759
REMARK 465 PHE E 760
REMARK 465 SER E 761
REMARK 465 ARG E 762
REMARK 465 HIS E 763
REMARK 465 VAL E 764
REMARK 465 LYS E 765
REMARK 465 LYS E 766
REMARK 465 LEU E 767
REMARK 465 GLN E 768
REMARK 465 LEU E 769
REMARK 465 ILE E 770
REMARK 465 GLU E 771
REMARK 465 GLY E 772
REMARK 465 ARG E 773
REMARK 465 GLN E 774
REMARK 465 HIS E 775
REMARK 465 ARG E 776
REMARK 465 SER E 777
REMARK 465 THR E 778
REMARK 465 TRP E 779
REMARK 465 SER E 780
REMARK 465 PRO E 781
REMARK 465 THR E 782
REMARK 465 MET E 783
REMARK 465 VAL E 784
REMARK 465 VAL E 785
REMARK 465 LEU E 786
REMARK 465 PHE E 787
REMARK 465 ARG E 788
REMARK 465 TRP E 789
REMARK 465 VAL E 790
REMARK 465 PRO E 791
REMARK 465 VAL E 792
REMARK 465 THR E 793
REMARK 465 ASP E 794
REMARK 465 ALA E 795
REMARK 465 TYR E 796
REMARK 465 TRP E 797
REMARK 465 GLN E 798
REMARK 465 ILE E 799
REMARK 465 LEU E 800
REMARK 465 PHE E 801
REMARK 465 SER E 802
REMARK 465 VAL E 803
REMARK 465 LEU E 804
REMARK 465 LYS E 805
REMARK 465 VAL E 806
REMARK 465 THR E 807
REMARK 465 ARG E 808
REMARK 465 ASN E 809
REMARK 465 LEU E 810
REMARK 465 LYS E 811
REMARK 465 GLU E 812
REMARK 465 LEU E 813
REMARK 465 ASP E 814
REMARK 465 LEU E 815
REMARK 465 SER E 816
REMARK 465 GLY E 817
REMARK 465 ASN E 818
REMARK 465 SER E 819
REMARK 465 LEU E 820
REMARK 465 SER E 821
REMARK 465 HIS E 822
REMARK 465 SER E 823
REMARK 465 ALA E 824
REMARK 465 VAL E 825
REMARK 465 LYS E 826
REMARK 465 SER E 827
REMARK 465 LEU E 828
REMARK 465 CYS E 829
REMARK 465 LYS E 830
REMARK 465 THR E 831
REMARK 465 LEU E 832
REMARK 465 ARG E 833
REMARK 465 ARG E 834
REMARK 465 PRO E 835
REMARK 465 ARG E 836
REMARK 465 CYS E 837
REMARK 465 LEU E 838
REMARK 465 LEU E 839
REMARK 465 GLU E 840
REMARK 465 THR E 841
REMARK 465 LEU E 842
REMARK 465 ARG E 843
REMARK 465 LEU E 844
REMARK 465 ALA E 845
REMARK 465 GLY E 846
REMARK 465 CYS E 847
REMARK 465 GLY E 848
REMARK 465 LEU E 849
REMARK 465 THR E 850
REMARK 465 ALA E 851
REMARK 465 GLU E 852
REMARK 465 ASP E 853
REMARK 465 CYS E 854
REMARK 465 LYS E 855
REMARK 465 ASP E 856
REMARK 465 LEU E 857
REMARK 465 ALA E 858
REMARK 465 PHE E 859
REMARK 465 GLY E 860
REMARK 465 LEU E 861
REMARK 465 ARG E 862
REMARK 465 ALA E 863
REMARK 465 ASN E 864
REMARK 465 GLN E 865
REMARK 465 THR E 866
REMARK 465 LEU E 867
REMARK 465 THR E 868
REMARK 465 GLU E 869
REMARK 465 LEU E 870
REMARK 465 ASP E 871
REMARK 465 LEU E 872
REMARK 465 SER E 873
REMARK 465 PHE E 874
REMARK 465 ASN E 875
REMARK 465 VAL E 876
REMARK 465 LEU E 877
REMARK 465 THR E 878
REMARK 465 ASP E 879
REMARK 465 ALA E 880
REMARK 465 GLY E 881
REMARK 465 ALA E 882
REMARK 465 LYS E 883
REMARK 465 HIS E 884
REMARK 465 LEU E 885
REMARK 465 CYS E 886
REMARK 465 GLN E 887
REMARK 465 ARG E 888
REMARK 465 LEU E 889
REMARK 465 ARG E 890
REMARK 465 GLN E 891
REMARK 465 PRO E 892
REMARK 465 SER E 893
REMARK 465 CYS E 894
REMARK 465 LYS E 895
REMARK 465 LEU E 896
REMARK 465 GLN E 897
REMARK 465 ARG E 898
REMARK 465 LEU E 899
REMARK 465 GLN E 900
REMARK 465 LEU E 901
REMARK 465 VAL E 902
REMARK 465 SER E 903
REMARK 465 CYS E 904
REMARK 465 GLY E 905
REMARK 465 LEU E 906
REMARK 465 THR E 907
REMARK 465 SER E 908
REMARK 465 ASP E 909
REMARK 465 CYS E 910
REMARK 465 CYS E 911
REMARK 465 GLN E 912
REMARK 465 ASP E 913
REMARK 465 LEU E 914
REMARK 465 ALA E 915
REMARK 465 SER E 916
REMARK 465 VAL E 917
REMARK 465 LEU E 918
REMARK 465 SER E 919
REMARK 465 ALA E 920
REMARK 465 SER E 921
REMARK 465 PRO E 922
REMARK 465 SER E 923
REMARK 465 LEU E 924
REMARK 465 LYS E 925
REMARK 465 GLU E 926
REMARK 465 LEU E 927
REMARK 465 ASP E 928
REMARK 465 LEU E 929
REMARK 465 GLN E 930
REMARK 465 GLN E 931
REMARK 465 ASN E 932
REMARK 465 ASN E 933
REMARK 465 LEU E 934
REMARK 465 ASP E 935
REMARK 465 ASP E 936
REMARK 465 VAL E 937
REMARK 465 GLY E 938
REMARK 465 VAL E 939
REMARK 465 ARG E 940
REMARK 465 LEU E 941
REMARK 465 LEU E 942
REMARK 465 CYS E 943
REMARK 465 GLU E 944
REMARK 465 GLY E 945
REMARK 465 LEU E 946
REMARK 465 ARG E 947
REMARK 465 HIS E 948
REMARK 465 PRO E 949
REMARK 465 ALA E 950
REMARK 465 CYS E 951
REMARK 465 LYS E 952
REMARK 465 LEU E 953
REMARK 465 ILE E 954
REMARK 465 ARG E 955
REMARK 465 LEU E 956
REMARK 465 GLY E 957
REMARK 465 LEU E 958
REMARK 465 ASP E 959
REMARK 465 GLN E 960
REMARK 465 THR E 961
REMARK 465 THR E 962
REMARK 465 LEU E 963
REMARK 465 SER E 964
REMARK 465 ASP E 965
REMARK 465 GLU E 966
REMARK 465 MET E 967
REMARK 465 ARG E 968
REMARK 465 GLN E 969
REMARK 465 GLU E 970
REMARK 465 LEU E 971
REMARK 465 ARG E 972
REMARK 465 ALA E 973
REMARK 465 LEU E 974
REMARK 465 GLU E 975
REMARK 465 GLN E 976
REMARK 465 GLU E 977
REMARK 465 LYS E 978
REMARK 465 PRO E 979
REMARK 465 GLN E 980
REMARK 465 LEU E 981
REMARK 465 LEU E 982
REMARK 465 ILE E 983
REMARK 465 PHE E 984
REMARK 465 SER E 985
REMARK 465 ARG E 986
REMARK 465 ARG E 987
REMARK 465 LYS E 988
REMARK 465 PRO E 989
REMARK 465 SER E 990
REMARK 465 VAL E 991
REMARK 465 MET E 992
REMARK 465 THR E 993
REMARK 465 PRO E 994
REMARK 465 THR E 995
REMARK 465 GLU E 996
REMARK 465 GLY E 997
REMARK 465 LEU E 998
REMARK 465 ASP E 999
REMARK 465 THR E 1000
REMARK 465 GLY E 1001
REMARK 465 GLU E 1002
REMARK 465 MET E 1003
REMARK 465 SER E 1004
REMARK 465 ASN E 1005
REMARK 465 SER E 1006
REMARK 465 THR E 1007
REMARK 465 SER E 1008
REMARK 465 SER E 1009
REMARK 465 LEU E 1010
REMARK 465 LYS E 1011
REMARK 465 ARG E 1012
REMARK 465 GLN E 1013
REMARK 465 ARG E 1014
REMARK 465 LEU E 1015
REMARK 465 GLY E 1016
REMARK 465 SER E 1017
REMARK 465 GLU E 1018
REMARK 465 ARG E 1019
REMARK 465 ALA E 1020
REMARK 465 ALA E 1021
REMARK 465 SER E 1022
REMARK 465 HIS E 1023
REMARK 465 VAL E 1024
REMARK 465 ALA E 1025
REMARK 465 GLN E 1026
REMARK 465 ALA E 1027
REMARK 465 ASN E 1028
REMARK 465 LEU E 1029
REMARK 465 LYS E 1030
REMARK 465 LEU E 1031
REMARK 465 LEU E 1032
REMARK 465 ASP E 1033
REMARK 465 VAL E 1034
REMARK 465 SER E 1035
REMARK 465 LYS E 1036
REMARK 465 ILE E 1037
REMARK 465 PHE E 1038
REMARK 465 PRO E 1039
REMARK 465 ILE E 1040
REMARK 465 ALA E 1041
REMARK 465 GLU E 1042
REMARK 465 ILE E 1043
REMARK 465 ALA E 1044
REMARK 465 GLU E 1045
REMARK 465 GLU E 1046
REMARK 465 SER E 1047
REMARK 465 SER E 1048
REMARK 465 PRO E 1049
REMARK 465 GLU E 1050
REMARK 465 VAL E 1051
REMARK 465 VAL E 1052
REMARK 465 PRO E 1053
REMARK 465 VAL E 1054
REMARK 465 GLU E 1055
REMARK 465 LEU E 1056
REMARK 465 LEU E 1057
REMARK 465 CYS E 1058
REMARK 465 VAL E 1059
REMARK 465 PRO E 1060
REMARK 465 SER E 1061
REMARK 465 PRO E 1062
REMARK 465 ALA E 1063
REMARK 465 SER E 1064
REMARK 465 GLN E 1065
REMARK 465 GLY E 1066
REMARK 465 ASP E 1067
REMARK 465 LEU E 1068
REMARK 465 HIS E 1069
REMARK 465 THR E 1070
REMARK 465 LYS E 1071
REMARK 465 PRO E 1072
REMARK 465 LEU E 1073
REMARK 465 GLY E 1074
REMARK 465 THR E 1075
REMARK 465 ASP E 1076
REMARK 465 ASP E 1077
REMARK 465 ASP E 1078
REMARK 465 LYS I 1351
REMARK 465 PRO I 1352
REMARK 465 GLY I 1353
REMARK 465 ASP I 1354
REMARK 465 LEU I 1355
REMARK 465 MET I 1356
REMARK 465 PRO I 1357
REMARK 465 ALA I 1358
REMARK 465 THR I 1359
REMARK 465 THR I 1360
REMARK 465 LEU I 1361
REMARK 465 ILE I 1362
REMARK 465 PRO I 1363
REMARK 465 PRO I 1364
REMARK 465 ALA I 1365
REMARK 465 ARG I 1366
REMARK 465 ILE I 1367
REMARK 465 ALA I 1368
REMARK 465 VAL I 1369
REMARK 465 PRO I 1370
REMARK 465 SER I 1371
REMARK 465 PRO I 1372
REMARK 465 LEU I 1373
REMARK 465 ASP I 1374
REMARK 465 ALA I 1375
REMARK 465 PRO I 1376
REMARK 465 GLN I 1377
REMARK 465 LEU I 1378
REMARK 465 LEU I 1379
REMARK 465 HIS I 1380
REMARK 465 PHE I 1381
REMARK 465 VAL I 1382
REMARK 465 ASP I 1383
REMARK 465 GLN I 1384
REMARK 465 TYR I 1385
REMARK 465 ARG I 1386
REMARK 465 GLU I 1387
REMARK 465 GLN I 1388
REMARK 465 LEU I 1389
REMARK 465 ILE I 1390
REMARK 465 ALA I 1391
REMARK 465 ARG I 1392
REMARK 465 VAL I 1393
REMARK 465 THR I 1394
REMARK 465 SER I 1395
REMARK 465 VAL I 1396
REMARK 465 GLU I 1397
REMARK 465 VAL I 1398
REMARK 465 VAL I 1399
REMARK 465 LEU I 1400
REMARK 465 ASP I 1401
REMARK 465 LYS I 1402
REMARK 465 LEU I 1403
REMARK 465 HIS I 1404
REMARK 465 GLY I 1405
REMARK 465 GLN I 1406
REMARK 465 VAL I 1407
REMARK 465 LEU I 1408
REMARK 465 SER I 1409
REMARK 465 GLN I 1410
REMARK 465 GLU I 1411
REMARK 465 GLN I 1412
REMARK 465 TYR I 1413
REMARK 465 GLU I 1414
REMARK 465 ARG I 1415
REMARK 465 VAL I 1416
REMARK 465 LEU I 1417
REMARK 465 ALA I 1418
REMARK 465 GLU I 1419
REMARK 465 ASN I 1420
REMARK 465 THR I 1421
REMARK 465 ARG I 1422
REMARK 465 PRO I 1423
REMARK 465 SER I 1424
REMARK 465 GLN I 1425
REMARK 465 MET I 1426
REMARK 465 ARG I 1427
REMARK 465 LYS I 1428
REMARK 465 LEU I 1429
REMARK 465 PHE I 1430
REMARK 465 SER I 1431
REMARK 465 LEU I 1432
REMARK 465 SER I 1433
REMARK 465 GLN I 1434
REMARK 465 SER I 1435
REMARK 465 TRP I 1436
REMARK 465 ASP I 1437
REMARK 465 ARG I 1438
REMARK 465 LYS I 1439
REMARK 465 CYS I 1440
REMARK 465 LYS I 1441
REMARK 465 ASP I 1442
REMARK 465 GLY I 1443
REMARK 465 LEU I 1444
REMARK 465 TYR I 1445
REMARK 465 GLN I 1446
REMARK 465 ALA I 1447
REMARK 465 LEU I 1448
REMARK 465 LYS I 1449
REMARK 465 GLU I 1450
REMARK 465 THR I 1451
REMARK 465 HIS I 1452
REMARK 465 PRO I 1453
REMARK 465 HIS I 1454
REMARK 465 LEU I 1455
REMARK 465 ILE I 1456
REMARK 465 MET I 1457
REMARK 465 GLU I 1458
REMARK 465 LEU I 1459
REMARK 465 TRP I 1460
REMARK 465 GLU I 1461
REMARK 465 LYS I 1462
REMARK 465 GLY I 1463
REMARK 465 SER I 1464
REMARK 465 LYS I 1465
REMARK 465 LYS I 1466
REMARK 465 GLY I 1467
REMARK 465 LEU I 1468
REMARK 465 LEU I 1469
REMARK 465 PRO I 1470
REMARK 465 LEU I 1471
REMARK 465 SER I 1472
REMARK 465 SER I 1473
REMARK 465 PRO F 1357
REMARK 465 ALA F 1358
REMARK 465 THR F 1359
REMARK 465 THR F 1360
REMARK 465 LEU F 1361
REMARK 465 ILE F 1362
REMARK 465 PRO F 1363
REMARK 465 PRO F 1364
REMARK 465 ALA F 1365
REMARK 465 ARG F 1366
REMARK 465 ILE F 1367
REMARK 465 ALA F 1368
REMARK 465 VAL F 1369
REMARK 465 PRO F 1370
REMARK 465 SER F 1371
REMARK 465 PRO F 1372
REMARK 465 LEU F 1373
REMARK 465 ASP F 1374
REMARK 465 ALA F 1375
REMARK 465 PRO F 1376
REMARK 465 GLN F 1377
REMARK 465 LEU F 1378
REMARK 465 LEU F 1379
REMARK 465 HIS F 1380
REMARK 465 PHE F 1381
REMARK 465 VAL F 1382
REMARK 465 ASP F 1383
REMARK 465 GLN F 1384
REMARK 465 TYR F 1385
REMARK 465 ARG F 1386
REMARK 465 GLU F 1387
REMARK 465 GLN F 1388
REMARK 465 LEU F 1389
REMARK 465 ILE F 1390
REMARK 465 ALA F 1391
REMARK 465 ARG F 1392
REMARK 465 VAL F 1393
REMARK 465 THR F 1394
REMARK 465 SER F 1395
REMARK 465 VAL F 1396
REMARK 465 GLU F 1397
REMARK 465 VAL F 1398
REMARK 465 VAL F 1399
REMARK 465 LEU F 1400
REMARK 465 ASP F 1401
REMARK 465 LYS F 1402
REMARK 465 LEU F 1403
REMARK 465 HIS F 1404
REMARK 465 GLY F 1405
REMARK 465 GLN F 1406
REMARK 465 VAL F 1407
REMARK 465 LEU F 1408
REMARK 465 SER F 1409
REMARK 465 GLN F 1410
REMARK 465 GLU F 1411
REMARK 465 GLN F 1412
REMARK 465 TYR F 1413
REMARK 465 GLU F 1414
REMARK 465 ARG F 1415
REMARK 465 VAL F 1416
REMARK 465 LEU F 1417
REMARK 465 ALA F 1418
REMARK 465 GLU F 1419
REMARK 465 ASN F 1420
REMARK 465 THR F 1421
REMARK 465 ARG F 1422
REMARK 465 PRO F 1423
REMARK 465 SER F 1424
REMARK 465 GLN F 1425
REMARK 465 MET F 1426
REMARK 465 ARG F 1427
REMARK 465 LYS F 1428
REMARK 465 LEU F 1429
REMARK 465 PHE F 1430
REMARK 465 SER F 1431
REMARK 465 LEU F 1432
REMARK 465 SER F 1433
REMARK 465 GLN F 1434
REMARK 465 SER F 1435
REMARK 465 TRP F 1436
REMARK 465 ASP F 1437
REMARK 465 ARG F 1438
REMARK 465 LYS F 1439
REMARK 465 CYS F 1440
REMARK 465 LYS F 1441
REMARK 465 ASP F 1442
REMARK 465 GLY F 1443
REMARK 465 LEU F 1444
REMARK 465 TYR F 1445
REMARK 465 GLN F 1446
REMARK 465 ALA F 1447
REMARK 465 LEU F 1448
REMARK 465 LYS F 1449
REMARK 465 GLU F 1450
REMARK 465 THR F 1451
REMARK 465 HIS F 1452
REMARK 465 PRO F 1453
REMARK 465 HIS F 1454
REMARK 465 LEU F 1455
REMARK 465 ILE F 1456
REMARK 465 MET F 1457
REMARK 465 GLU F 1458
REMARK 465 LEU F 1459
REMARK 465 TRP F 1460
REMARK 465 GLU F 1461
REMARK 465 LYS F 1462
REMARK 465 GLY F 1463
REMARK 465 SER F 1464
REMARK 465 LYS F 1465
REMARK 465 LYS F 1466
REMARK 465 GLY F 1467
REMARK 465 LEU F 1468
REMARK 465 LEU F 1469
REMARK 465 PRO F 1470
REMARK 465 LEU F 1471
REMARK 465 SER F 1472
REMARK 465 SER F 1473
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470 M RES CSSEQI ATOMS
REMARK 470 ASP A 18 CG OD1 OD2
REMARK 470 GLU A 64 CG CD OE1 OE2
REMARK 470 LEU A 233 CG CD1 CD2
REMARK 470 ASP A 234 CG OD1 OD2
REMARK 470 GLU A 265 CG CD OE1 OE2
REMARK 470 SER G1213 N
REMARK 470 LYS C1220 CG CD CE NZ
REMARK 470 LEU C1226 CG CD1 CD2
REMARK 470 PHE C1228 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 ILE C1229 CG1 CG2 CD1
REMARK 470 ASP D 18 CG OD1 OD2
REMARK 470 GLU D 64 CG CD OE1 OE2
REMARK 470 LEU D 233 CG CD1 CD2
REMARK 470 ASP D 234 CG OD1 OD2
REMARK 470 GLU D 265 CG CD OE1 OE2
REMARK 470 PHE E1079 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 TRP E1080 CG CD1 CD2 NE1 CE2 CE3 CZ2
REMARK 470 TRP E1080 CZ3 CH2
REMARK 470 SER I1213 N
REMARK 470 LYS I1277 CG CD CE NZ
REMARK 470 LYS F1220 CG CD CE NZ
REMARK 470 ILE F1229 CG1 CG2 CD1
REMARK 470 LYS F1277 CG CD CE NZ
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500 M RES CSSEQI PSI PHI
REMARK 500 LYS A 51 71.78 48.12
REMARK 500 SER A 156 -132.23 55.23
REMARK 500 SER A 230 -159.76 -150.78
REMARK 500 ASP A 251 17.53 59.62
REMARK 500 GLU A 268 -53.43 -124.75
REMARK 500 GLU A 282 45.31 -90.68
REMARK 500 ALA A 316 148.63 -170.63
REMARK 500 TRP A 375 52.42 -140.76
REMARK 500 VAL A 419 -71.88 -102.97
REMARK 500 GLU A 438 70.21 51.75
REMARK 500 GLN A 684 -3.04 68.58
REMARK 500 GLN A 696 48.39 -143.50
REMARK 500 SER A 730 -119.64 54.93
REMARK 500 GLU A 768 -5.54 -58.61
REMARK 500 MET A 771 -165.44 -114.26
REMARK 500 ASN A 777 78.04 -114.54
REMARK 500 ASN A 810 -65.68 -93.58
REMARK 500 ARG A 839 -74.25 -83.24
REMARK 500 TRP B1080 49.44 -94.36
REMARK 500 LEU B1151 70.23 59.42
REMARK 500 HIS B1203 16.55 -141.17
REMARK 500 PHE G1228 71.90 51.23
REMARK 500 PRO G1243 -177.39 -69.19
REMARK 500 PRO G1254 -171.46 -67.36
REMARK 500 SER G1293 -159.58 -138.63
REMARK 500 ASP G1341 15.21 -140.97
REMARK 500 LEU C1215 72.15 58.66
REMARK 500 LYS C1220 -132.78 52.72
REMARK 500 HIS C1223 60.37 32.50
REMARK 500 LEU C1237 65.25 61.19
REMARK 500 SER C1255 -2.41 80.05
REMARK 500 TYR D 79 -11.52 99.17
REMARK 500 PRO D 116 -177.07 -69.33
REMARK 500 SER D 230 -159.42 -150.57
REMARK 500 GLU D 268 -38.26 -131.88
REMARK 500 GLU D 282 45.49 -90.10
REMARK 500 ALA D 316 148.86 -170.90
REMARK 500 GLN D 334 119.93 -168.95
REMARK 500 VAL D 419 -72.48 -108.78
REMARK 500 ASP D 437 -161.22 -170.45
REMARK 500 GLU D 438 70.61 57.20
REMARK 500 GLU D 493 40.19 -100.94
REMARK 500 ARG D 685 19.72 -140.67
REMARK 500 GLN D 696 43.65 -142.99
REMARK 500 TRP D 729 -62.59 -102.23
REMARK 500 SER D 730 -82.24 -91.41
REMARK 500 ALA D 754 46.68 30.51
REMARK 500 MET D 771 -160.33 -117.46
REMARK 500 ASN D 777 77.19 -119.60
REMARK 500 ASN D 810 -66.80 -91.64
REMARK 500
REMARK 500 THIS ENTRY HAS 71 RAMACHANDRAN OUTLIERS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: EMD-22074 RELATED DB: EMDB
REMARK 900 DPP9 DIRECTLY SEQUESTERS THE NLRP1 C-TERMINUS TO REPRESS
REMARK 900 INFLAMMASOME ACTIVATION
DBREF 6X6A A 1 863 UNP Q86TI2 DPP9_HUMAN 1 863
DBREF 6X6A B 1 1212 UNP Q9C000 NLRP1_HUMAN 1 1212
DBREF 6X6A G 1213 1473 UNP Q9C000 NLRP1_HUMAN 1213 1473
DBREF 6X6A C 1213 1473 UNP Q9C000 NLRP1_HUMAN 1213 1473
DBREF 6X6A D 1 863 UNP Q86TI2 DPP9_HUMAN 1 863
DBREF 6X6A E 1 1212 UNP Q9C000 NLRP1_HUMAN 1 1212
DBREF 6X6A I 1213 1473 UNP Q9C000 NLRP1_HUMAN 1213 1473
DBREF 6X6A F 1213 1473 UNP Q9C000 NLRP1_HUMAN 1213 1473
SEQRES 1 A 863 MET ALA THR THR GLY THR PRO THR ALA ASP ARG GLY ASP
SEQRES 2 A 863 ALA ALA ALA THR ASP ASP PRO ALA ALA ARG PHE GLN VAL
SEQRES 3 A 863 GLN LYS HIS SER TRP ASP GLY LEU ARG SER ILE ILE HIS
SEQRES 4 A 863 GLY SER ARG LYS TYR SER GLY LEU ILE VAL ASN LYS ALA
SEQRES 5 A 863 PRO HIS ASP PHE GLN PHE VAL GLN LYS THR ASP GLU SER
SEQRES 6 A 863 GLY PRO HIS SER HIS ARG LEU TYR TYR LEU GLY MET PRO
SEQRES 7 A 863 TYR GLY SER ARG GLU ASN SER LEU LEU TYR SER GLU ILE
SEQRES 8 A 863 PRO LYS LYS VAL ARG LYS GLU ALA LEU LEU LEU LEU SER
SEQRES 9 A 863 TRP LYS GLN MET LEU ASP HIS PHE GLN ALA THR PRO HIS
SEQRES 10 A 863 HIS GLY VAL TYR SER ARG GLU GLU GLU LEU LEU ARG GLU
SEQRES 11 A 863 ARG LYS ARG LEU GLY VAL PHE GLY ILE THR SER TYR ASP
SEQRES 12 A 863 PHE HIS SER GLU SER GLY LEU PHE LEU PHE GLN ALA SER
SEQRES 13 A 863 ASN SER LEU PHE HIS CYS ARG ASP GLY GLY LYS ASN GLY
SEQRES 14 A 863 PHE MET VAL SER PRO MET LYS PRO LEU GLU ILE LYS THR
SEQRES 15 A 863 GLN CYS SER GLY PRO ARG MET ASP PRO LYS ILE CYS PRO
SEQRES 16 A 863 ALA ASP PRO ALA PHE PHE SER PHE ILE ASN ASN SER ASP
SEQRES 17 A 863 LEU TRP VAL ALA ASN ILE GLU THR GLY GLU GLU ARG ARG
SEQRES 18 A 863 LEU THR PHE CYS HIS GLN GLY LEU SER ASN VAL LEU ASP
SEQRES 19 A 863 ASP PRO LYS SER ALA GLY VAL ALA THR PHE VAL ILE GLN
SEQRES 20 A 863 GLU GLU PHE ASP ARG PHE THR GLY TYR TRP TRP CYS PRO
SEQRES 21 A 863 THR ALA SER TRP GLU GLY SER GLU GLY LEU LYS THR LEU
SEQRES 22 A 863 ARG ILE LEU TYR GLU GLU VAL ASP GLU SER GLU VAL GLU
SEQRES 23 A 863 VAL ILE HIS VAL PRO SER PRO ALA LEU GLU GLU ARG LYS
SEQRES 24 A 863 THR ASP SER TYR ARG TYR PRO ARG THR GLY SER LYS ASN
SEQRES 25 A 863 PRO LYS ILE ALA LEU LYS LEU ALA GLU PHE GLN THR ASP
SEQRES 26 A 863 SER GLN GLY LYS ILE VAL SER THR GLN GLU LYS GLU LEU
SEQRES 27 A 863 VAL GLN PRO PHE SER SER LEU PHE PRO LYS VAL GLU TYR
SEQRES 28 A 863 ILE ALA ARG ALA GLY TRP THR ARG ASP GLY LYS TYR ALA
SEQRES 29 A 863 TRP ALA MET PHE LEU ASP ARG PRO GLN GLN TRP LEU GLN
SEQRES 30 A 863 LEU VAL LEU LEU PRO PRO ALA LEU PHE ILE PRO SER THR
SEQRES 31 A 863 GLU ASN GLU GLU GLN ARG LEU ALA SER ALA ARG ALA VAL
SEQRES 32 A 863 PRO ARG ASN VAL GLN PRO TYR VAL VAL TYR GLU GLU VAL
SEQRES 33 A 863 THR ASN VAL TRP ILE ASN VAL HIS ASP ILE PHE TYR PRO
SEQRES 34 A 863 PHE PRO GLN SER GLU GLY GLU ASP GLU LEU CYS PHE LEU
SEQRES 35 A 863 ARG ALA ASN GLU CYS LYS THR GLY PHE CYS HIS LEU TYR
SEQRES 36 A 863 LYS VAL THR ALA VAL LEU LYS SER GLN GLY TYR ASP TRP
SEQRES 37 A 863 SER GLU PRO PHE SER PRO GLY GLU ASP GLU PHE LYS CYS
SEQRES 38 A 863 PRO ILE LYS GLU GLU ILE ALA LEU THR SER GLY GLU TRP
SEQRES 39 A 863 GLU VAL LEU ALA ARG HIS GLY SER LYS ILE TRP VAL ASN
SEQRES 40 A 863 GLU GLU THR LYS LEU VAL TYR PHE GLN GLY THR LYS ASP
SEQRES 41 A 863 THR PRO LEU GLU HIS HIS LEU TYR VAL VAL SER TYR GLU
SEQRES 42 A 863 ALA ALA GLY GLU ILE VAL ARG LEU THR THR PRO GLY PHE
SEQRES 43 A 863 SER HIS SER CYS SER MET SER GLN ASN PHE ASP MET PHE
SEQRES 44 A 863 VAL SER HIS TYR SER SER VAL SER THR PRO PRO CYS VAL
SEQRES 45 A 863 HIS VAL TYR LYS LEU SER GLY PRO ASP ASP ASP PRO LEU
SEQRES 46 A 863 HIS LYS GLN PRO ARG PHE TRP ALA SER MET MET GLU ALA
SEQRES 47 A 863 ALA SER CYS PRO PRO ASP TYR VAL PRO PRO GLU ILE PHE
SEQRES 48 A 863 HIS PHE HIS THR ARG SER ASP VAL ARG LEU TYR GLY MET
SEQRES 49 A 863 ILE TYR LYS PRO HIS ALA LEU GLN PRO GLY LYS LYS HIS
SEQRES 50 A 863 PRO THR VAL LEU PHE VAL TYR GLY GLY PRO GLN VAL GLN
SEQRES 51 A 863 LEU VAL ASN ASN SER PHE LYS GLY ILE LYS TYR LEU ARG
SEQRES 52 A 863 LEU ASN THR LEU ALA SER LEU GLY TYR ALA VAL VAL VAL
SEQRES 53 A 863 ILE ASP GLY ARG GLY SER CYS GLN ARG GLY LEU ARG PHE
SEQRES 54 A 863 GLU GLY ALA LEU LYS ASN GLN MET GLY GLN VAL GLU ILE
SEQRES 55 A 863 GLU ASP GLN VAL GLU GLY LEU GLN PHE VAL ALA GLU LYS
SEQRES 56 A 863 TYR GLY PHE ILE ASP LEU SER ARG VAL ALA ILE HIS GLY
SEQRES 57 A 863 TRP SER TYR GLY GLY PHE LEU SER LEU MET GLY LEU ILE
SEQRES 58 A 863 HIS LYS PRO GLN VAL PHE LYS VAL ALA ILE ALA GLY ALA
SEQRES 59 A 863 PRO VAL THR VAL TRP MET ALA TYR ASP THR GLY TYR THR
SEQRES 60 A 863 GLU ARG TYR MET ASP VAL PRO GLU ASN ASN GLN HIS GLY
SEQRES 61 A 863 TYR GLU ALA GLY SER VAL ALA LEU HIS VAL GLU LYS LEU
SEQRES 62 A 863 PRO ASN GLU PRO ASN ARG LEU LEU ILE LEU HIS GLY PHE
SEQRES 63 A 863 LEU ASP GLU ASN VAL HIS PHE PHE HIS THR ASN PHE LEU
SEQRES 64 A 863 VAL SER GLN LEU ILE ARG ALA GLY LYS PRO TYR GLN LEU
SEQRES 65 A 863 GLN ILE TYR PRO ASN GLU ARG HIS SER ILE ARG CYS PRO
SEQRES 66 A 863 GLU SER GLY GLU HIS TYR GLU VAL THR LEU LEU HIS PHE
SEQRES 67 A 863 LEU GLN GLU TYR LEU
SEQRES 1 B 1212 MET ALA GLY GLY ALA TRP GLY ARG LEU ALA CYS TYR LEU
SEQRES 2 B 1212 GLU PHE LEU LYS LYS GLU GLU LEU LYS GLU PHE GLN LEU
SEQRES 3 B 1212 LEU LEU ALA ASN LYS ALA HIS SER ARG SER SER SER GLY
SEQRES 4 B 1212 GLU THR PRO ALA GLN PRO GLU LYS THR SER GLY MET GLU
SEQRES 5 B 1212 VAL ALA SER TYR LEU VAL ALA GLN TYR GLY GLU GLN ARG
SEQRES 6 B 1212 ALA TRP ASP LEU ALA LEU HIS THR TRP GLU GLN MET GLY
SEQRES 7 B 1212 LEU ARG SER LEU CYS ALA GLN ALA GLN GLU GLY ALA GLY
SEQRES 8 B 1212 HIS SER PRO SER PHE PRO TYR SER PRO SER GLU PRO HIS
SEQRES 9 B 1212 LEU GLY SER PRO SER GLN PRO THR SER THR ALA VAL LEU
SEQRES 10 B 1212 MET PRO TRP ILE HIS GLU LEU PRO ALA GLY CYS THR GLN
SEQRES 11 B 1212 GLY SER GLU ARG ARG VAL LEU ARG GLN LEU PRO ASP THR
SEQRES 12 B 1212 SER GLY ARG ARG TRP ARG GLU ILE SER ALA SER LEU LEU
SEQRES 13 B 1212 TYR GLN ALA LEU PRO SER SER PRO ASP HIS GLU SER PRO
SEQRES 14 B 1212 SER GLN GLU SER PRO ASN ALA PRO THR SER THR ALA VAL
SEQRES 15 B 1212 LEU GLY SER TRP GLY SER PRO PRO GLN PRO SER LEU ALA
SEQRES 16 B 1212 PRO ARG GLU GLN GLU ALA PRO GLY THR GLN TRP PRO LEU
SEQRES 17 B 1212 ASP GLU THR SER GLY ILE TYR TYR THR GLU ILE ARG GLU
SEQRES 18 B 1212 ARG GLU ARG GLU LYS SER GLU LYS GLY ARG PRO PRO TRP
SEQRES 19 B 1212 ALA ALA VAL VAL GLY THR PRO PRO GLN ALA HIS THR SER
SEQRES 20 B 1212 LEU GLN PRO HIS HIS HIS PRO TRP GLU PRO SER VAL ARG
SEQRES 21 B 1212 GLU SER LEU CYS SER THR TRP PRO TRP LYS ASN GLU ASP
SEQRES 22 B 1212 PHE ASN GLN LYS PHE THR GLN LEU LEU LEU LEU GLN ARG
SEQRES 23 B 1212 PRO HIS PRO ARG SER GLN ASP PRO LEU VAL LYS ARG SER
SEQRES 24 B 1212 TRP PRO ASP TYR VAL GLU GLU ASN ARG GLY HIS LEU ILE
SEQRES 25 B 1212 GLU ILE ARG ASP LEU PHE GLY PRO GLY LEU ASP THR GLN
SEQRES 26 B 1212 GLU PRO ARG ILE VAL ILE LEU GLN GLY ALA ALA GLY ILE
SEQRES 27 B 1212 GLY LYS SER THR LEU ALA ARG GLN VAL LYS GLU ALA TRP
SEQRES 28 B 1212 GLY ARG GLY GLN LEU TYR GLY ASP ARG PHE GLN HIS VAL
SEQRES 29 B 1212 PHE TYR PHE SER CYS ARG GLU LEU ALA GLN SER LYS VAL
SEQRES 30 B 1212 VAL SER LEU ALA GLU LEU ILE GLY LYS ASP GLY THR ALA
SEQRES 31 B 1212 THR PRO ALA PRO ILE ARG GLN ILE LEU SER ARG PRO GLU
SEQRES 32 B 1212 ARG LEU LEU PHE ILE LEU ASP GLY VAL ASP GLU PRO GLY
SEQRES 33 B 1212 TRP VAL LEU GLN GLU PRO SER SER GLU LEU CYS LEU HIS
SEQRES 34 B 1212 TRP SER GLN PRO GLN PRO ALA ASP ALA LEU LEU GLY SER
SEQRES 35 B 1212 LEU LEU GLY LYS THR ILE LEU PRO GLU ALA SER PHE LEU
SEQRES 36 B 1212 ILE THR ALA ARG THR THR ALA LEU GLN ASN LEU ILE PRO
SEQRES 37 B 1212 SER LEU GLU GLN ALA ARG TRP VAL GLU VAL LEU GLY PHE
SEQRES 38 B 1212 SER GLU SER SER ARG LYS GLU TYR PHE TYR ARG TYR PHE
SEQRES 39 B 1212 THR ASP GLU ARG GLN ALA ILE ARG ALA PHE ARG LEU VAL
SEQRES 40 B 1212 LYS SER ASN LYS GLU LEU TRP ALA LEU CYS LEU VAL PRO
SEQRES 41 B 1212 TRP VAL SER TRP LEU ALA CYS THR CYS LEU MET GLN GLN
SEQRES 42 B 1212 MET LYS ARG LYS GLU LYS LEU THR LEU THR SER LYS THR
SEQRES 43 B 1212 THR THR THR LEU CYS LEU HIS TYR LEU ALA GLN ALA LEU
SEQRES 44 B 1212 GLN ALA GLN PRO LEU GLY PRO GLN LEU ARG ASP LEU CYS
SEQRES 45 B 1212 SER LEU ALA ALA GLU GLY ILE TRP GLN LYS LYS THR LEU
SEQRES 46 B 1212 PHE SER PRO ASP ASP LEU ARG LYS HIS GLY LEU ASP GLY
SEQRES 47 B 1212 ALA ILE ILE SER THR PHE LEU LYS MET GLY ILE LEU GLN
SEQRES 48 B 1212 GLU HIS PRO ILE PRO LEU SER TYR SER PHE ILE HIS LEU
SEQRES 49 B 1212 CYS PHE GLN GLU PHE PHE ALA ALA MET SER TYR VAL LEU
SEQRES 50 B 1212 GLU ASP GLU LYS GLY ARG GLY LYS HIS SER ASN CYS ILE
SEQRES 51 B 1212 ILE ASP LEU GLU LYS THR LEU GLU ALA TYR GLY ILE HIS
SEQRES 52 B 1212 GLY LEU PHE GLY ALA SER THR THR ARG PHE LEU LEU GLY
SEQRES 53 B 1212 LEU LEU SER ASP GLU GLY GLU ARG GLU MET GLU ASN ILE
SEQRES 54 B 1212 PHE HIS CYS ARG LEU SER GLN GLY ARG ASN LEU MET GLN
SEQRES 55 B 1212 TRP VAL PRO SER LEU GLN LEU LEU LEU GLN PRO HIS SER
SEQRES 56 B 1212 LEU GLU SER LEU HIS CYS LEU TYR GLU THR ARG ASN LYS
SEQRES 57 B 1212 THR PHE LEU THR GLN VAL MET ALA HIS PHE GLU GLU MET
SEQRES 58 B 1212 GLY MET CYS VAL GLU THR ASP MET GLU LEU LEU VAL CYS
SEQRES 59 B 1212 THR PHE CYS ILE LYS PHE SER ARG HIS VAL LYS LYS LEU
SEQRES 60 B 1212 GLN LEU ILE GLU GLY ARG GLN HIS ARG SER THR TRP SER
SEQRES 61 B 1212 PRO THR MET VAL VAL LEU PHE ARG TRP VAL PRO VAL THR
SEQRES 62 B 1212 ASP ALA TYR TRP GLN ILE LEU PHE SER VAL LEU LYS VAL
SEQRES 63 B 1212 THR ARG ASN LEU LYS GLU LEU ASP LEU SER GLY ASN SER
SEQRES 64 B 1212 LEU SER HIS SER ALA VAL LYS SER LEU CYS LYS THR LEU
SEQRES 65 B 1212 ARG ARG PRO ARG CYS LEU LEU GLU THR LEU ARG LEU ALA
SEQRES 66 B 1212 GLY CYS GLY LEU THR ALA GLU ASP CYS LYS ASP LEU ALA
SEQRES 67 B 1212 PHE GLY LEU ARG ALA ASN GLN THR LEU THR GLU LEU ASP
SEQRES 68 B 1212 LEU SER PHE ASN VAL LEU THR ASP ALA GLY ALA LYS HIS
SEQRES 69 B 1212 LEU CYS GLN ARG LEU ARG GLN PRO SER CYS LYS LEU GLN
SEQRES 70 B 1212 ARG LEU GLN LEU VAL SER CYS GLY LEU THR SER ASP CYS
SEQRES 71 B 1212 CYS GLN ASP LEU ALA SER VAL LEU SER ALA SER PRO SER
SEQRES 72 B 1212 LEU LYS GLU LEU ASP LEU GLN GLN ASN ASN LEU ASP ASP
SEQRES 73 B 1212 VAL GLY VAL ARG LEU LEU CYS GLU GLY LEU ARG HIS PRO
SEQRES 74 B 1212 ALA CYS LYS LEU ILE ARG LEU GLY LEU ASP GLN THR THR
SEQRES 75 B 1212 LEU SER ASP GLU MET ARG GLN GLU LEU ARG ALA LEU GLU
SEQRES 76 B 1212 GLN GLU LYS PRO GLN LEU LEU ILE PHE SER ARG ARG LYS
SEQRES 77 B 1212 PRO SER VAL MET THR PRO THR GLU GLY LEU ASP THR GLY
SEQRES 78 B 1212 GLU MET SER ASN SER THR SER SER LEU LYS ARG GLN ARG
SEQRES 79 B 1212 LEU GLY SER GLU ARG ALA ALA SER HIS VAL ALA GLN ALA
SEQRES 80 B 1212 ASN LEU LYS LEU LEU ASP VAL SER LYS ILE PHE PRO ILE
SEQRES 81 B 1212 ALA GLU ILE ALA GLU GLU SER SER PRO GLU VAL VAL PRO
SEQRES 82 B 1212 VAL GLU LEU LEU CYS VAL PRO SER PRO ALA SER GLN GLY
SEQRES 83 B 1212 ASP LEU HIS THR LYS PRO LEU GLY THR ASP ASP ASP PHE
SEQRES 84 B 1212 TRP GLY PRO THR GLY PRO VAL ALA THR GLU VAL VAL ASP
SEQRES 85 B 1212 LYS GLU LYS ASN LEU TYR ARG VAL HIS PHE PRO VAL ALA
SEQRES 86 B 1212 GLY SER TYR ARG TRP PRO ASN THR GLY LEU CYS PHE VAL
SEQRES 87 B 1212 MET ARG GLU ALA VAL THR VAL GLU ILE GLU PHE CYS VAL
SEQRES 88 B 1212 TRP ASP GLN PHE LEU GLY GLU ILE ASN PRO GLN HIS SER
SEQRES 89 B 1212 TRP MET VAL ALA GLY PRO LEU LEU ASP ILE LYS ALA GLU
SEQRES 90 B 1212 PRO GLY ALA VAL GLU ALA VAL HIS LEU PRO HIS PHE VAL
SEQRES 91 B 1212 ALA LEU GLN GLY GLY HIS VAL ASP THR SER LEU PHE GLN
SEQRES 92 B 1212 MET ALA HIS PHE LYS GLU GLU GLY MET LEU LEU GLU LYS
SEQRES 93 B 1212 PRO ALA ARG VAL GLU LEU HIS HIS ILE VAL LEU GLU ASN
SEQRES 94 B 1212 PRO SER PHE
SEQRES 1 G 261 SER PRO LEU GLY VAL LEU LEU LYS MET ILE HIS ASN ALA
SEQRES 2 G 261 LEU ARG PHE ILE PRO VAL THR SER VAL VAL LEU LEU TYR
SEQRES 3 G 261 HIS ARG VAL HIS PRO GLU GLU VAL THR PHE HIS LEU TYR
SEQRES 4 G 261 LEU ILE PRO SER ASP CYS SER ILE ARG LYS ALA ILE ASP
SEQRES 5 G 261 ASP LEU GLU MET LYS PHE GLN PHE VAL ARG ILE HIS LYS
SEQRES 6 G 261 PRO PRO PRO LEU THR PRO LEU TYR MET GLY CYS ARG TYR
SEQRES 7 G 261 THR VAL SER GLY SER GLY SER GLY MET LEU GLU ILE LEU
SEQRES 8 G 261 PRO LYS GLU LEU GLU LEU CYS TYR ARG SER PRO GLY GLU
SEQRES 9 G 261 ASP GLN LEU PHE SER GLU PHE TYR VAL GLY HIS LEU GLY
SEQRES 10 G 261 SER GLY ILE ARG LEU GLN VAL LYS ASP LYS LYS ASP GLU
SEQRES 11 G 261 THR LEU VAL TRP GLU ALA LEU VAL LYS PRO GLY ASP LEU
SEQRES 12 G 261 MET PRO ALA THR THR LEU ILE PRO PRO ALA ARG ILE ALA
SEQRES 13 G 261 VAL PRO SER PRO LEU ASP ALA PRO GLN LEU LEU HIS PHE
SEQRES 14 G 261 VAL ASP GLN TYR ARG GLU GLN LEU ILE ALA ARG VAL THR
SEQRES 15 G 261 SER VAL GLU VAL VAL LEU ASP LYS LEU HIS GLY GLN VAL
SEQRES 16 G 261 LEU SER GLN GLU GLN TYR GLU ARG VAL LEU ALA GLU ASN
SEQRES 17 G 261 THR ARG PRO SER GLN MET ARG LYS LEU PHE SER LEU SER
SEQRES 18 G 261 GLN SER TRP ASP ARG LYS CYS LYS ASP GLY LEU TYR GLN
SEQRES 19 G 261 ALA LEU LYS GLU THR HIS PRO HIS LEU ILE MET GLU LEU
SEQRES 20 G 261 TRP GLU LYS GLY SER LYS LYS GLY LEU LEU PRO LEU SER
SEQRES 21 G 261 SER
SEQRES 1 C 261 SER PRO LEU GLY VAL LEU LEU LYS MET ILE HIS ASN ALA
SEQRES 2 C 261 LEU ARG PHE ILE PRO VAL THR SER VAL VAL LEU LEU TYR
SEQRES 3 C 261 HIS ARG VAL HIS PRO GLU GLU VAL THR PHE HIS LEU TYR
SEQRES 4 C 261 LEU ILE PRO SER ASP CYS SER ILE ARG LYS ALA ILE ASP
SEQRES 5 C 261 ASP LEU GLU MET LYS PHE GLN PHE VAL ARG ILE HIS LYS
SEQRES 6 C 261 PRO PRO PRO LEU THR PRO LEU TYR MET GLY CYS ARG TYR
SEQRES 7 C 261 THR VAL SER GLY SER GLY SER GLY MET LEU GLU ILE LEU
SEQRES 8 C 261 PRO LYS GLU LEU GLU LEU CYS TYR ARG SER PRO GLY GLU
SEQRES 9 C 261 ASP GLN LEU PHE SER GLU PHE TYR VAL GLY HIS LEU GLY
SEQRES 10 C 261 SER GLY ILE ARG LEU GLN VAL LYS ASP LYS LYS ASP GLU
SEQRES 11 C 261 THR LEU VAL TRP GLU ALA LEU VAL LYS PRO GLY ASP LEU
SEQRES 12 C 261 MET PRO ALA THR THR LEU ILE PRO PRO ALA ARG ILE ALA
SEQRES 13 C 261 VAL PRO SER PRO LEU ASP ALA PRO GLN LEU LEU HIS PHE
SEQRES 14 C 261 VAL ASP GLN TYR ARG GLU GLN LEU ILE ALA ARG VAL THR
SEQRES 15 C 261 SER VAL GLU VAL VAL LEU ASP LYS LEU HIS GLY GLN VAL
SEQRES 16 C 261 LEU SER GLN GLU GLN TYR GLU ARG VAL LEU ALA GLU ASN
SEQRES 17 C 261 THR ARG PRO SER GLN MET ARG LYS LEU PHE SER LEU SER
SEQRES 18 C 261 GLN SER TRP ASP ARG LYS CYS LYS ASP GLY LEU TYR GLN
SEQRES 19 C 261 ALA LEU LYS GLU THR HIS PRO HIS LEU ILE MET GLU LEU
SEQRES 20 C 261 TRP GLU LYS GLY SER LYS LYS GLY LEU LEU PRO LEU SER
SEQRES 21 C 261 SER
SEQRES 1 D 863 MET ALA THR THR GLY THR PRO THR ALA ASP ARG GLY ASP
SEQRES 2 D 863 ALA ALA ALA THR ASP ASP PRO ALA ALA ARG PHE GLN VAL
SEQRES 3 D 863 GLN LYS HIS SER TRP ASP GLY LEU ARG SER ILE ILE HIS
SEQRES 4 D 863 GLY SER ARG LYS TYR SER GLY LEU ILE VAL ASN LYS ALA
SEQRES 5 D 863 PRO HIS ASP PHE GLN PHE VAL GLN LYS THR ASP GLU SER
SEQRES 6 D 863 GLY PRO HIS SER HIS ARG LEU TYR TYR LEU GLY MET PRO
SEQRES 7 D 863 TYR GLY SER ARG GLU ASN SER LEU LEU TYR SER GLU ILE
SEQRES 8 D 863 PRO LYS LYS VAL ARG LYS GLU ALA LEU LEU LEU LEU SER
SEQRES 9 D 863 TRP LYS GLN MET LEU ASP HIS PHE GLN ALA THR PRO HIS
SEQRES 10 D 863 HIS GLY VAL TYR SER ARG GLU GLU GLU LEU LEU ARG GLU
SEQRES 11 D 863 ARG LYS ARG LEU GLY VAL PHE GLY ILE THR SER TYR ASP
SEQRES 12 D 863 PHE HIS SER GLU SER GLY LEU PHE LEU PHE GLN ALA SER
SEQRES 13 D 863 ASN SER LEU PHE HIS CYS ARG ASP GLY GLY LYS ASN GLY
SEQRES 14 D 863 PHE MET VAL SER PRO MET LYS PRO LEU GLU ILE LYS THR
SEQRES 15 D 863 GLN CYS SER GLY PRO ARG MET ASP PRO LYS ILE CYS PRO
SEQRES 16 D 863 ALA ASP PRO ALA PHE PHE SER PHE ILE ASN ASN SER ASP
SEQRES 17 D 863 LEU TRP VAL ALA ASN ILE GLU THR GLY GLU GLU ARG ARG
SEQRES 18 D 863 LEU THR PHE CYS HIS GLN GLY LEU SER ASN VAL LEU ASP
SEQRES 19 D 863 ASP PRO LYS SER ALA GLY VAL ALA THR PHE VAL ILE GLN
SEQRES 20 D 863 GLU GLU PHE ASP ARG PHE THR GLY TYR TRP TRP CYS PRO
SEQRES 21 D 863 THR ALA SER TRP GLU GLY SER GLU GLY LEU LYS THR LEU
SEQRES 22 D 863 ARG ILE LEU TYR GLU GLU VAL ASP GLU SER GLU VAL GLU
SEQRES 23 D 863 VAL ILE HIS VAL PRO SER PRO ALA LEU GLU GLU ARG LYS
SEQRES 24 D 863 THR ASP SER TYR ARG TYR PRO ARG THR GLY SER LYS ASN
SEQRES 25 D 863 PRO LYS ILE ALA LEU LYS LEU ALA GLU PHE GLN THR ASP
SEQRES 26 D 863 SER GLN GLY LYS ILE VAL SER THR GLN GLU LYS GLU LEU
SEQRES 27 D 863 VAL GLN PRO PHE SER SER LEU PHE PRO LYS VAL GLU TYR
SEQRES 28 D 863 ILE ALA ARG ALA GLY TRP THR ARG ASP GLY LYS TYR ALA
SEQRES 29 D 863 TRP ALA MET PHE LEU ASP ARG PRO GLN GLN TRP LEU GLN
SEQRES 30 D 863 LEU VAL LEU LEU PRO PRO ALA LEU PHE ILE PRO SER THR
SEQRES 31 D 863 GLU ASN GLU GLU GLN ARG LEU ALA SER ALA ARG ALA VAL
SEQRES 32 D 863 PRO ARG ASN VAL GLN PRO TYR VAL VAL TYR GLU GLU VAL
SEQRES 33 D 863 THR ASN VAL TRP ILE ASN VAL HIS ASP ILE PHE TYR PRO
SEQRES 34 D 863 PHE PRO GLN SER GLU GLY GLU ASP GLU LEU CYS PHE LEU
SEQRES 35 D 863 ARG ALA ASN GLU CYS LYS THR GLY PHE CYS HIS LEU TYR
SEQRES 36 D 863 LYS VAL THR ALA VAL LEU LYS SER GLN GLY TYR ASP TRP
SEQRES 37 D 863 SER GLU PRO PHE SER PRO GLY GLU ASP GLU PHE LYS CYS
SEQRES 38 D 863 PRO ILE LYS GLU GLU ILE ALA LEU THR SER GLY GLU TRP
SEQRES 39 D 863 GLU VAL LEU ALA ARG HIS GLY SER LYS ILE TRP VAL ASN
SEQRES 40 D 863 GLU GLU THR LYS LEU VAL TYR PHE GLN GLY THR LYS ASP
SEQRES 41 D 863 THR PRO LEU GLU HIS HIS LEU TYR VAL VAL SER TYR GLU
SEQRES 42 D 863 ALA ALA GLY GLU ILE VAL ARG LEU THR THR PRO GLY PHE
SEQRES 43 D 863 SER HIS SER CYS SER MET SER GLN ASN PHE ASP MET PHE
SEQRES 44 D 863 VAL SER HIS TYR SER SER VAL SER THR PRO PRO CYS VAL
SEQRES 45 D 863 HIS VAL TYR LYS LEU SER GLY PRO ASP ASP ASP PRO LEU
SEQRES 46 D 863 HIS LYS GLN PRO ARG PHE TRP ALA SER MET MET GLU ALA
SEQRES 47 D 863 ALA SER CYS PRO PRO ASP TYR VAL PRO PRO GLU ILE PHE
SEQRES 48 D 863 HIS PHE HIS THR ARG SER ASP VAL ARG LEU TYR GLY MET
SEQRES 49 D 863 ILE TYR LYS PRO HIS ALA LEU GLN PRO GLY LYS LYS HIS
SEQRES 50 D 863 PRO THR VAL LEU PHE VAL TYR GLY GLY PRO GLN VAL GLN
SEQRES 51 D 863 LEU VAL ASN ASN SER PHE LYS GLY ILE LYS TYR LEU ARG
SEQRES 52 D 863 LEU ASN THR LEU ALA SER LEU GLY TYR ALA VAL VAL VAL
SEQRES 53 D 863 ILE ASP GLY ARG GLY SER CYS GLN ARG GLY LEU ARG PHE
SEQRES 54 D 863 GLU GLY ALA LEU LYS ASN GLN MET GLY GLN VAL GLU ILE
SEQRES 55 D 863 GLU ASP GLN VAL GLU GLY LEU GLN PHE VAL ALA GLU LYS
SEQRES 56 D 863 TYR GLY PHE ILE ASP LEU SER ARG VAL ALA ILE HIS GLY
SEQRES 57 D 863 TRP SER TYR GLY GLY PHE LEU SER LEU MET GLY LEU ILE
SEQRES 58 D 863 HIS LYS PRO GLN VAL PHE LYS VAL ALA ILE ALA GLY ALA
SEQRES 59 D 863 PRO VAL THR VAL TRP MET ALA TYR ASP THR GLY TYR THR
SEQRES 60 D 863 GLU ARG TYR MET ASP VAL PRO GLU ASN ASN GLN HIS GLY
SEQRES 61 D 863 TYR GLU ALA GLY SER VAL ALA LEU HIS VAL GLU LYS LEU
SEQRES 62 D 863 PRO ASN GLU PRO ASN ARG LEU LEU ILE LEU HIS GLY PHE
SEQRES 63 D 863 LEU ASP GLU ASN VAL HIS PHE PHE HIS THR ASN PHE LEU
SEQRES 64 D 863 VAL SER GLN LEU ILE ARG ALA GLY LYS PRO TYR GLN LEU
SEQRES 65 D 863 GLN ILE TYR PRO ASN GLU ARG HIS SER ILE ARG CYS PRO
SEQRES 66 D 863 GLU SER GLY GLU HIS TYR GLU VAL THR LEU LEU HIS PHE
SEQRES 67 D 863 LEU GLN GLU TYR LEU
SEQRES 1 E 1212 MET ALA GLY GLY ALA TRP GLY ARG LEU ALA CYS TYR LEU
SEQRES 2 E 1212 GLU PHE LEU LYS LYS GLU GLU LEU LYS GLU PHE GLN LEU
SEQRES 3 E 1212 LEU LEU ALA ASN LYS ALA HIS SER ARG SER SER SER GLY
SEQRES 4 E 1212 GLU THR PRO ALA GLN PRO GLU LYS THR SER GLY MET GLU
SEQRES 5 E 1212 VAL ALA SER TYR LEU VAL ALA GLN TYR GLY GLU GLN ARG
SEQRES 6 E 1212 ALA TRP ASP LEU ALA LEU HIS THR TRP GLU GLN MET GLY
SEQRES 7 E 1212 LEU ARG SER LEU CYS ALA GLN ALA GLN GLU GLY ALA GLY
SEQRES 8 E 1212 HIS SER PRO SER PHE PRO TYR SER PRO SER GLU PRO HIS
SEQRES 9 E 1212 LEU GLY SER PRO SER GLN PRO THR SER THR ALA VAL LEU
SEQRES 10 E 1212 MET PRO TRP ILE HIS GLU LEU PRO ALA GLY CYS THR GLN
SEQRES 11 E 1212 GLY SER GLU ARG ARG VAL LEU ARG GLN LEU PRO ASP THR
SEQRES 12 E 1212 SER GLY ARG ARG TRP ARG GLU ILE SER ALA SER LEU LEU
SEQRES 13 E 1212 TYR GLN ALA LEU PRO SER SER PRO ASP HIS GLU SER PRO
SEQRES 14 E 1212 SER GLN GLU SER PRO ASN ALA PRO THR SER THR ALA VAL
SEQRES 15 E 1212 LEU GLY SER TRP GLY SER PRO PRO GLN PRO SER LEU ALA
SEQRES 16 E 1212 PRO ARG GLU GLN GLU ALA PRO GLY THR GLN TRP PRO LEU
SEQRES 17 E 1212 ASP GLU THR SER GLY ILE TYR TYR THR GLU ILE ARG GLU
SEQRES 18 E 1212 ARG GLU ARG GLU LYS SER GLU LYS GLY ARG PRO PRO TRP
SEQRES 19 E 1212 ALA ALA VAL VAL GLY THR PRO PRO GLN ALA HIS THR SER
SEQRES 20 E 1212 LEU GLN PRO HIS HIS HIS PRO TRP GLU PRO SER VAL ARG
SEQRES 21 E 1212 GLU SER LEU CYS SER THR TRP PRO TRP LYS ASN GLU ASP
SEQRES 22 E 1212 PHE ASN GLN LYS PHE THR GLN LEU LEU LEU LEU GLN ARG
SEQRES 23 E 1212 PRO HIS PRO ARG SER GLN ASP PRO LEU VAL LYS ARG SER
SEQRES 24 E 1212 TRP PRO ASP TYR VAL GLU GLU ASN ARG GLY HIS LEU ILE
SEQRES 25 E 1212 GLU ILE ARG ASP LEU PHE GLY PRO GLY LEU ASP THR GLN
SEQRES 26 E 1212 GLU PRO ARG ILE VAL ILE LEU GLN GLY ALA ALA GLY ILE
SEQRES 27 E 1212 GLY LYS SER THR LEU ALA ARG GLN VAL LYS GLU ALA TRP
SEQRES 28 E 1212 GLY ARG GLY GLN LEU TYR GLY ASP ARG PHE GLN HIS VAL
SEQRES 29 E 1212 PHE TYR PHE SER CYS ARG GLU LEU ALA GLN SER LYS VAL
SEQRES 30 E 1212 VAL SER LEU ALA GLU LEU ILE GLY LYS ASP GLY THR ALA
SEQRES 31 E 1212 THR PRO ALA PRO ILE ARG GLN ILE LEU SER ARG PRO GLU
SEQRES 32 E 1212 ARG LEU LEU PHE ILE LEU ASP GLY VAL ASP GLU PRO GLY
SEQRES 33 E 1212 TRP VAL LEU GLN GLU PRO SER SER GLU LEU CYS LEU HIS
SEQRES 34 E 1212 TRP SER GLN PRO GLN PRO ALA ASP ALA LEU LEU GLY SER
SEQRES 35 E 1212 LEU LEU GLY LYS THR ILE LEU PRO GLU ALA SER PHE LEU
SEQRES 36 E 1212 ILE THR ALA ARG THR THR ALA LEU GLN ASN LEU ILE PRO
SEQRES 37 E 1212 SER LEU GLU GLN ALA ARG TRP VAL GLU VAL LEU GLY PHE
SEQRES 38 E 1212 SER GLU SER SER ARG LYS GLU TYR PHE TYR ARG TYR PHE
SEQRES 39 E 1212 THR ASP GLU ARG GLN ALA ILE ARG ALA PHE ARG LEU VAL
SEQRES 40 E 1212 LYS SER ASN LYS GLU LEU TRP ALA LEU CYS LEU VAL PRO
SEQRES 41 E 1212 TRP VAL SER TRP LEU ALA CYS THR CYS LEU MET GLN GLN
SEQRES 42 E 1212 MET LYS ARG LYS GLU LYS LEU THR LEU THR SER LYS THR
SEQRES 43 E 1212 THR THR THR LEU CYS LEU HIS TYR LEU ALA GLN ALA LEU
SEQRES 44 E 1212 GLN ALA GLN PRO LEU GLY PRO GLN LEU ARG ASP LEU CYS
SEQRES 45 E 1212 SER LEU ALA ALA GLU GLY ILE TRP GLN LYS LYS THR LEU
SEQRES 46 E 1212 PHE SER PRO ASP ASP LEU ARG LYS HIS GLY LEU ASP GLY
SEQRES 47 E 1212 ALA ILE ILE SER THR PHE LEU LYS MET GLY ILE LEU GLN
SEQRES 48 E 1212 GLU HIS PRO ILE PRO LEU SER TYR SER PHE ILE HIS LEU
SEQRES 49 E 1212 CYS PHE GLN GLU PHE PHE ALA ALA MET SER TYR VAL LEU
SEQRES 50 E 1212 GLU ASP GLU LYS GLY ARG GLY LYS HIS SER ASN CYS ILE
SEQRES 51 E 1212 ILE ASP LEU GLU LYS THR LEU GLU ALA TYR GLY ILE HIS
SEQRES 52 E 1212 GLY LEU PHE GLY ALA SER THR THR ARG PHE LEU LEU GLY
SEQRES 53 E 1212 LEU LEU SER ASP GLU GLY GLU ARG GLU MET GLU ASN ILE
SEQRES 54 E 1212 PHE HIS CYS ARG LEU SER GLN GLY ARG ASN LEU MET GLN
SEQRES 55 E 1212 TRP VAL PRO SER LEU GLN LEU LEU LEU GLN PRO HIS SER
SEQRES 56 E 1212 LEU GLU SER LEU HIS CYS LEU TYR GLU THR ARG ASN LYS
SEQRES 57 E 1212 THR PHE LEU THR GLN VAL MET ALA HIS PHE GLU GLU MET
SEQRES 58 E 1212 GLY MET CYS VAL GLU THR ASP MET GLU LEU LEU VAL CYS
SEQRES 59 E 1212 THR PHE CYS ILE LYS PHE SER ARG HIS VAL LYS LYS LEU
SEQRES 60 E 1212 GLN LEU ILE GLU GLY ARG GLN HIS ARG SER THR TRP SER
SEQRES 61 E 1212 PRO THR MET VAL VAL LEU PHE ARG TRP VAL PRO VAL THR
SEQRES 62 E 1212 ASP ALA TYR TRP GLN ILE LEU PHE SER VAL LEU LYS VAL
SEQRES 63 E 1212 THR ARG ASN LEU LYS GLU LEU ASP LEU SER GLY ASN SER
SEQRES 64 E 1212 LEU SER HIS SER ALA VAL LYS SER LEU CYS LYS THR LEU
SEQRES 65 E 1212 ARG ARG PRO ARG CYS LEU LEU GLU THR LEU ARG LEU ALA
SEQRES 66 E 1212 GLY CYS GLY LEU THR ALA GLU ASP CYS LYS ASP LEU ALA
SEQRES 67 E 1212 PHE GLY LEU ARG ALA ASN GLN THR LEU THR GLU LEU ASP
SEQRES 68 E 1212 LEU SER PHE ASN VAL LEU THR ASP ALA GLY ALA LYS HIS
SEQRES 69 E 1212 LEU CYS GLN ARG LEU ARG GLN PRO SER CYS LYS LEU GLN
SEQRES 70 E 1212 ARG LEU GLN LEU VAL SER CYS GLY LEU THR SER ASP CYS
SEQRES 71 E 1212 CYS GLN ASP LEU ALA SER VAL LEU SER ALA SER PRO SER
SEQRES 72 E 1212 LEU LYS GLU LEU ASP LEU GLN GLN ASN ASN LEU ASP ASP
SEQRES 73 E 1212 VAL GLY VAL ARG LEU LEU CYS GLU GLY LEU ARG HIS PRO
SEQRES 74 E 1212 ALA CYS LYS LEU ILE ARG LEU GLY LEU ASP GLN THR THR
SEQRES 75 E 1212 LEU SER ASP GLU MET ARG GLN GLU LEU ARG ALA LEU GLU
SEQRES 76 E 1212 GLN GLU LYS PRO GLN LEU LEU ILE PHE SER ARG ARG LYS
SEQRES 77 E 1212 PRO SER VAL MET THR PRO THR GLU GLY LEU ASP THR GLY
SEQRES 78 E 1212 GLU MET SER ASN SER THR SER SER LEU LYS ARG GLN ARG
SEQRES 79 E 1212 LEU GLY SER GLU ARG ALA ALA SER HIS VAL ALA GLN ALA
SEQRES 80 E 1212 ASN LEU LYS LEU LEU ASP VAL SER LYS ILE PHE PRO ILE
SEQRES 81 E 1212 ALA GLU ILE ALA GLU GLU SER SER PRO GLU VAL VAL PRO
SEQRES 82 E 1212 VAL GLU LEU LEU CYS VAL PRO SER PRO ALA SER GLN GLY
SEQRES 83 E 1212 ASP LEU HIS THR LYS PRO LEU GLY THR ASP ASP ASP PHE
SEQRES 84 E 1212 TRP GLY PRO THR GLY PRO VAL ALA THR GLU VAL VAL ASP
SEQRES 85 E 1212 LYS GLU LYS ASN LEU TYR ARG VAL HIS PHE PRO VAL ALA
SEQRES 86 E 1212 GLY SER TYR ARG TRP PRO ASN THR GLY LEU CYS PHE VAL
SEQRES 87 E 1212 MET ARG GLU ALA VAL THR VAL GLU ILE GLU PHE CYS VAL
SEQRES 88 E 1212 TRP ASP GLN PHE LEU GLY GLU ILE ASN PRO GLN HIS SER
SEQRES 89 E 1212 TRP MET VAL ALA GLY PRO LEU LEU ASP ILE LYS ALA GLU
SEQRES 90 E 1212 PRO GLY ALA VAL GLU ALA VAL HIS LEU PRO HIS PHE VAL
SEQRES 91 E 1212 ALA LEU GLN GLY GLY HIS VAL ASP THR SER LEU PHE GLN
SEQRES 92 E 1212 MET ALA HIS PHE LYS GLU GLU GLY MET LEU LEU GLU LYS
SEQRES 93 E 1212 PRO ALA ARG VAL GLU LEU HIS HIS ILE VAL LEU GLU ASN
SEQRES 94 E 1212 PRO SER PHE
SEQRES 1 I 261 SER PRO LEU GLY VAL LEU LEU LYS MET ILE HIS ASN ALA
SEQRES 2 I 261 LEU ARG PHE ILE PRO VAL THR SER VAL VAL LEU LEU TYR
SEQRES 3 I 261 HIS ARG VAL HIS PRO GLU GLU VAL THR PHE HIS LEU TYR
SEQRES 4 I 261 LEU ILE PRO SER ASP CYS SER ILE ARG LYS ALA ILE ASP
SEQRES 5 I 261 ASP LEU GLU MET LYS PHE GLN PHE VAL ARG ILE HIS LYS
SEQRES 6 I 261 PRO PRO PRO LEU THR PRO LEU TYR MET GLY CYS ARG TYR
SEQRES 7 I 261 THR VAL SER GLY SER GLY SER GLY MET LEU GLU ILE LEU
SEQRES 8 I 261 PRO LYS GLU LEU GLU LEU CYS TYR ARG SER PRO GLY GLU
SEQRES 9 I 261 ASP GLN LEU PHE SER GLU PHE TYR VAL GLY HIS LEU GLY
SEQRES 10 I 261 SER GLY ILE ARG LEU GLN VAL LYS ASP LYS LYS ASP GLU
SEQRES 11 I 261 THR LEU VAL TRP GLU ALA LEU VAL LYS PRO GLY ASP LEU
SEQRES 12 I 261 MET PRO ALA THR THR LEU ILE PRO PRO ALA ARG ILE ALA
SEQRES 13 I 261 VAL PRO SER PRO LEU ASP ALA PRO GLN LEU LEU HIS PHE
SEQRES 14 I 261 VAL ASP GLN TYR ARG GLU GLN LEU ILE ALA ARG VAL THR
SEQRES 15 I 261 SER VAL GLU VAL VAL LEU ASP LYS LEU HIS GLY GLN VAL
SEQRES 16 I 261 LEU SER GLN GLU GLN TYR GLU ARG VAL LEU ALA GLU ASN
SEQRES 17 I 261 THR ARG PRO SER GLN MET ARG LYS LEU PHE SER LEU SER
SEQRES 18 I 261 GLN SER TRP ASP ARG LYS CYS LYS ASP GLY LEU TYR GLN
SEQRES 19 I 261 ALA LEU LYS GLU THR HIS PRO HIS LEU ILE MET GLU LEU
SEQRES 20 I 261 TRP GLU LYS GLY SER LYS LYS GLY LEU LEU PRO LEU SER
SEQRES 21 I 261 SER
SEQRES 1 F 261 SER PRO LEU GLY VAL LEU LEU LYS MET ILE HIS ASN ALA
SEQRES 2 F 261 LEU ARG PHE ILE PRO VAL THR SER VAL VAL LEU LEU TYR
SEQRES 3 F 261 HIS ARG VAL HIS PRO GLU GLU VAL THR PHE HIS LEU TYR
SEQRES 4 F 261 LEU ILE PRO SER ASP CYS SER ILE ARG LYS ALA ILE ASP
SEQRES 5 F 261 ASP LEU GLU MET LYS PHE GLN PHE VAL ARG ILE HIS LYS
SEQRES 6 F 261 PRO PRO PRO LEU THR PRO LEU TYR MET GLY CYS ARG TYR
SEQRES 7 F 261 THR VAL SER GLY SER GLY SER GLY MET LEU GLU ILE LEU
SEQRES 8 F 261 PRO LYS GLU LEU GLU LEU CYS TYR ARG SER PRO GLY GLU
SEQRES 9 F 261 ASP GLN LEU PHE SER GLU PHE TYR VAL GLY HIS LEU GLY
SEQRES 10 F 261 SER GLY ILE ARG LEU GLN VAL LYS ASP LYS LYS ASP GLU
SEQRES 11 F 261 THR LEU VAL TRP GLU ALA LEU VAL LYS PRO GLY ASP LEU
SEQRES 12 F 261 MET PRO ALA THR THR LEU ILE PRO PRO ALA ARG ILE ALA
SEQRES 13 F 261 VAL PRO SER PRO LEU ASP ALA PRO GLN LEU LEU HIS PHE
SEQRES 14 F 261 VAL ASP GLN TYR ARG GLU GLN LEU ILE ALA ARG VAL THR
SEQRES 15 F 261 SER VAL GLU VAL VAL LEU ASP LYS LEU HIS GLY GLN VAL
SEQRES 16 F 261 LEU SER GLN GLU GLN TYR GLU ARG VAL LEU ALA GLU ASN
SEQRES 17 F 261 THR ARG PRO SER GLN MET ARG LYS LEU PHE SER LEU SER
SEQRES 18 F 261 GLN SER TRP ASP ARG LYS CYS LYS ASP GLY LEU TYR GLN
SEQRES 19 F 261 ALA LEU LYS GLU THR HIS PRO HIS LEU ILE MET GLU LEU
SEQRES 20 F 261 TRP GLU LYS GLY SER LYS LYS GLY LEU LEU PRO LEU SER
SEQRES 21 F 261 SER
HELIX 1 AA1 SER A 30 VAL A 49 1 20
HELIX 2 AA2 PRO A 116 VAL A 120 5 5
HELIX 3 AA3 SER A 122 ARG A 133 1 12
HELIX 4 AA4 THR A 243 PHE A 250 1 8
HELIX 5 AA5 PRO A 341 PHE A 346 1 6
HELIX 6 AA6 PRO A 382 ALA A 384 5 3
HELIX 7 AA7 ASN A 392 VAL A 403 1 12
HELIX 8 AA8 GLU A 446 GLY A 450 1 5
HELIX 9 AA9 ASP A 583 LYS A 587 5 5
HELIX 10 AB1 TYR A 661 GLY A 671 1 11
HELIX 11 AB2 GLY A 686 GLY A 691 1 6
HELIX 12 AB3 ALA A 692 LYS A 694 5 3
HELIX 13 AB4 VAL A 700 TYR A 716 1 17
HELIX 14 AB5 SER A 730 LYS A 743 1 14
HELIX 15 AB6 VAL A 758 TYR A 762 5 5
HELIX 16 AB7 ASP A 763 MET A 771 1 9
HELIX 17 AB8 ASN A 777 SER A 785 1 9
HELIX 18 AB9 VAL A 786 LEU A 793 5 8
HELIX 19 AC1 HIS A 812 GLY A 827 1 16
HELIX 20 AC2 CYS A 844 LEU A 863 1 20
HELIX 21 AC3 TRP B 1132 GLY B 1137 1 6
HELIX 22 AC4 ASP G 1256 PHE G 1270 1 15
HELIX 23 AC5 SER C 1258 PHE C 1270 1 13
HELIX 24 AC6 SER C 1295 LEU C 1300 1 6
HELIX 25 AC7 SER D 30 VAL D 49 1 20
HELIX 26 AC8 PRO D 116 VAL D 120 5 5
HELIX 27 AC9 SER D 122 ARG D 133 1 12
HELIX 28 AD1 THR D 243 PHE D 250 1 8
HELIX 29 AD2 ALA D 294 ARG D 298 5 5
HELIX 30 AD3 PRO D 341 PHE D 346 1 6
HELIX 31 AD4 PRO D 382 ALA D 384 5 3
HELIX 32 AD5 ASN D 392 VAL D 403 1 12
HELIX 33 AD6 TYR D 661 GLY D 671 1 11
HELIX 34 AD7 GLY D 686 GLY D 691 1 6
HELIX 35 AD8 ALA D 692 LYS D 694 5 3
HELIX 36 AD9 VAL D 700 TYR D 716 1 17
HELIX 37 AE1 SER D 730 LYS D 743 1 14
HELIX 38 AE2 VAL D 758 TYR D 762 5 5
HELIX 39 AE3 ASP D 763 MET D 771 1 9
HELIX 40 AE4 ASN D 777 SER D 785 1 9
HELIX 41 AE5 VAL D 786 LEU D 793 5 8
HELIX 42 AE6 HIS D 812 GLY D 827 1 16
HELIX 43 AE7 CYS D 844 LEU D 863 1 20
HELIX 44 AE8 TRP E 1132 GLY E 1137 1 6
HELIX 45 AE9 PRO E 1141 TRP E 1145 5 5
HELIX 46 AF1 ASP I 1256 PHE I 1270 1 15
HELIX 47 AF2 PHE F 1228 LEU F 1236 1 9
HELIX 48 AF3 SER F 1258 PHE F 1270 1 13
SHEET 1 AA1 4 HIS A 54 GLN A 60 0
SHEET 2 AA1 4 HIS A 68 GLY A 76 -1 O ARG A 71 N VAL A 59
SHEET 3 AA1 4 SER A 85 PRO A 92 -1 O SER A 85 N GLY A 76
SHEET 4 AA1 4 LYS A 106 GLN A 107 -1 O LYS A 106 N TYR A 88
SHEET 1 AA2 4 LEU A 100 LEU A 103 0
SHEET 2 AA2 4 GLY B1191 GLU B1195 -1 O MET B1192 N LEU A 102
SHEET 3 AA2 4 MET B1184 PHE B1187 -1 N HIS B1186 O LEU B1193
SHEET 4 AA2 4 LEU G1215 LEU G1218 -1 O VAL G1217 N ALA B1185
SHEET 1 AA3 4 TYR A 142 HIS A 145 0
SHEET 2 AA3 4 LEU A 150 ALA A 155 -1 O LEU A 152 N ASP A 143
SHEET 3 AA3 4 SER A 158 ARG A 163 -1 O CYS A 162 N PHE A 151
SHEET 4 AA3 4 LEU A 178 GLU A 179 -1 O LEU A 178 N HIS A 161
SHEET 1 AA4 4 MET A 189 ILE A 193 0
SHEET 2 AA4 4 PHE A 200 ASN A 205 -1 O ILE A 204 N MET A 189
SHEET 3 AA4 4 ASP A 208 ASN A 213 -1 O TRP A 210 N PHE A 203
SHEET 4 AA4 4 GLU A 219 ARG A 221 -1 O ARG A 220 N VAL A 211
SHEET 1 AA5 3 LYS A 237 ALA A 239 0
SHEET 2 AA5 3 LYS A 271 ASP A 281 -1 O VAL A 280 N SER A 238
SHEET 3 AA5 3 SER A 263 TRP A 264 -1 N SER A 263 O THR A 272
SHEET 1 AA6 5 TYR A 256 TRP A 258 0
SHEET 2 AA6 5 LYS A 271 ASP A 281 -1 O LEU A 276 N TRP A 257
SHEET 3 AA6 5 LYS A 314 THR A 324 -1 O ALA A 320 N ILE A 275
SHEET 4 AA6 5 ILE A 330 LEU A 338 -1 O GLN A 334 N GLU A 321
SHEET 5 AA6 5 PHE A 386 PRO A 388 -1 O ILE A 387 N GLU A 337
SHEET 1 AA7 2 VAL A 287 PRO A 291 0
SHEET 2 AA7 2 THR A 300 ARG A 304 -1 O ASP A 301 N VAL A 290
SHEET 1 AA8 4 TYR A 351 TRP A 357 0
SHEET 2 AA8 4 ALA A 364 LEU A 369 -1 O TRP A 365 N GLY A 356
SHEET 3 AA8 4 TRP A 375 LEU A 381 -1 O LEU A 381 N ALA A 364
SHEET 4 AA8 4 TYR A 410 VAL A 416 -1 O TYR A 410 N LEU A 380
SHEET 1 AA9 4 PHE A 427 PRO A 429 0
SHEET 2 AA9 4 CYS A 440 ASN A 445 -1 O LEU A 442 N TYR A 428
SHEET 3 AA9 4 HIS A 453 ALA A 459 -1 O VAL A 457 N PHE A 441
SHEET 4 AA9 4 ILE A 483 ALA A 488 -1 O GLU A 485 N THR A 458
SHEET 1 AB1 4 TRP A 505 ASN A 507 0
SHEET 2 AB1 4 LEU A 512 GLY A 517 -1 O TYR A 514 N TRP A 505
SHEET 3 AB1 4 HIS A 526 SER A 531 -1 O VAL A 530 N VAL A 513
SHEET 4 AB1 4 VAL A 539 ARG A 540 -1 O VAL A 539 N VAL A 529
SHEET 1 AB2 4 SER A 547 MET A 552 0
SHEET 2 AB2 4 MET A 558 SER A 564 -1 O HIS A 562 N SER A 549
SHEET 3 AB2 4 CYS A 571 SER A 578 -1 O HIS A 573 N SER A 561
SHEET 4 AB2 4 GLN A 588 MET A 596 -1 O ALA A 593 N VAL A 574
SHEET 1 AB3 8 GLU A 609 HIS A 614 0
SHEET 2 AB3 8 ARG A 620 TYR A 626 -1 O GLY A 623 N PHE A 611
SHEET 3 AB3 8 ALA A 673 ILE A 677 -1 O VAL A 676 N MET A 624
SHEET 4 AB3 8 HIS A 637 VAL A 643 1 N VAL A 640 O ALA A 673
SHEET 5 AB3 8 ILE A 719 TRP A 729 1 O ALA A 725 N LEU A 641
SHEET 6 AB3 8 VAL A 749 GLY A 753 1 O ILE A 751 N GLY A 728
SHEET 7 AB3 8 LEU A 800 GLY A 805 1 O LEU A 803 N ALA A 752
SHEET 8 AB3 8 GLN A 831 TYR A 835 1 O GLN A 831 N ILE A 802
SHEET 1 AB4 4 GLU B1089 ASP B1092 0
SHEET 2 AB4 4 LEU B1097 PHE B1102 -1 O ARG B1099 N GLU B1089
SHEET 3 AB4 4 VAL B1123 PHE B1129 -1 O ILE B1127 N TYR B1098
SHEET 4 AB4 4 LEU B1152 LYS B1155 -1 O LYS B1155 N GLU B1126
SHEET 1 AB5 4 CYS B1116 VAL B1118 0
SHEET 2 AB5 4 ALA B1163 LEU B1166 -1 O HIS B1165 N CYS B1116
SHEET 3 AB5 4 ILE B1205 LEU B1207 -1 O ILE B1205 N LEU B1166
SHEET 4 AB5 4 ARG B1199 VAL B1200 -1 N ARG B1199 O VAL B1206
SHEET 1 AB6 2 PRO G1230 VAL G1231 0
SHEET 2 AB6 2 LEU G1284 TYR G1285 -1 O LEU G1284 N VAL G1231
SHEET 1 AB7 2 TYR G1238 HIS G1239 0
SHEET 2 AB7 2 VAL G1273 ARG G1274 -1 O VAL G1273 N HIS G1239
SHEET 1 AB8 3 THR G1247 TYR G1251 0
SHEET 2 AB8 3 PHE G1320 TYR G1324 -1 O PHE G1323 N PHE G1248
SHEET 3 AB8 3 GLU G1301 ILE G1302 -1 N GLU G1301 O TYR G1324
SHEET 1 AB9 4 GLU G1306 GLU G1308 0
SHEET 2 AB9 4 ARG G1289 SER G1293 -1 N TYR G1290 O LEU G1307
SHEET 3 AB9 4 GLN G1335 ASP G1338 -1 O GLN G1335 N SER G1293
SHEET 4 AB9 4 LEU G1344 TRP G1346 -1 O TRP G1346 N VAL G1336
SHEET 1 AC1 4 TYR C1238 VAL C1241 0
SHEET 2 AC1 4 VAL C1246 HIS C1249 -1 O HIS C1249 N TYR C1238
SHEET 3 AC1 4 PHE C1323 GLY C1326 -1 O VAL C1325 N VAL C1246
SHEET 4 AC1 4 GLU C1301 ILE C1302 -1 N GLU C1301 O TYR C1324
SHEET 1 AC2 4 GLU C1306 LEU C1309 0
SHEET 2 AC2 4 CYS C1288 GLY C1294 -1 N TYR C1290 O LEU C1307
SHEET 3 AC2 4 ILE C1332 ASP C1338 -1 O GLN C1335 N SER C1293
SHEET 4 AC2 4 TRP C1346 VAL C1350 -1 O ALA C1348 N LEU C1334
SHEET 1 AC3 4 HIS D 54 GLN D 60 0
SHEET 2 AC3 4 HIS D 68 GLY D 76 -1 O LEU D 75 N HIS D 54
SHEET 3 AC3 4 SER D 85 PRO D 92 -1 O SER D 85 N GLY D 76
SHEET 4 AC3 4 LYS D 106 GLN D 107 -1 O LYS D 106 N TYR D 88
SHEET 1 AC4 8 LEU D 100 LEU D 103 0
SHEET 2 AC4 8 GLY E1191 GLU E1195 -1 O MET E1192 N LEU D 102
SHEET 3 AC4 8 MET E1184 PHE E1187 -1 N MET E1184 O GLU E1195
SHEET 4 AC4 8 PRO I1214 LEU I1218 -1 O GLY I1216 N ALA E1185
SHEET 5 AC4 8 LEU E1152 LYS E1155 -1 N LEU E1152 O LEU I1215
SHEET 6 AC4 8 VAL E1123 PHE E1129 -1 N GLU E1126 O LYS E1155
SHEET 7 AC4 8 LEU E1097 PHE E1102 -1 N TYR E1098 O ILE E1127
SHEET 8 AC4 8 GLU E1089 VAL E1090 -1 N GLU E1089 O ARG E1099
SHEET 1 AC5 4 TYR D 142 HIS D 145 0
SHEET 2 AC5 4 LEU D 150 ALA D 155 -1 O LEU D 152 N ASP D 143
SHEET 3 AC5 4 SER D 158 ARG D 163 -1 O PHE D 160 N PHE D 153
SHEET 4 AC5 4 LEU D 178 GLU D 179 -1 O LEU D 178 N HIS D 161
SHEET 1 AC6 4 MET D 189 ILE D 193 0
SHEET 2 AC6 4 PHE D 200 ASN D 205 -1 O ILE D 204 N MET D 189
SHEET 3 AC6 4 ASP D 208 ASN D 213 -1 O TRP D 210 N PHE D 203
SHEET 4 AC6 4 GLU D 219 ARG D 221 -1 O ARG D 220 N VAL D 211
SHEET 1 AC7 4 LYS D 237 ALA D 239 0
SHEET 2 AC7 4 ILE D 275 ASP D 281 -1 O VAL D 280 N SER D 238
SHEET 3 AC7 4 LYS D 314 THR D 324 -1 O LYS D 318 N TYR D 277
SHEET 4 AC7 4 LYS D 271 LEU D 273 -1 N LYS D 271 O THR D 324
SHEET 1 AC8 5 TYR D 256 TRP D 258 0
SHEET 2 AC8 5 ILE D 275 ASP D 281 -1 O LEU D 276 N TRP D 257
SHEET 3 AC8 5 LYS D 314 THR D 324 -1 O LYS D 318 N TYR D 277
SHEET 4 AC8 5 ILE D 330 LEU D 338 -1 O GLN D 334 N GLU D 321
SHEET 5 AC8 5 PHE D 386 PRO D 388 -1 O ILE D 387 N GLU D 337
SHEET 1 AC9 2 VAL D 287 PRO D 291 0
SHEET 2 AC9 2 THR D 300 ARG D 304 -1 O ASP D 301 N VAL D 290
SHEET 1 AD1 4 TYR D 351 TRP D 357 0
SHEET 2 AD1 4 ALA D 364 LEU D 369 -1 O LEU D 369 N TYR D 351
SHEET 3 AD1 4 TRP D 375 LEU D 381 -1 O GLN D 377 N PHE D 368
SHEET 4 AD1 4 TYR D 410 VAL D 416 -1 O TYR D 410 N LEU D 380
SHEET 1 AD2 4 PHE D 427 PRO D 429 0
SHEET 2 AD2 4 CYS D 440 ASN D 445 -1 O LEU D 442 N TYR D 428
SHEET 3 AD2 4 HIS D 453 ALA D 459 -1 O VAL D 457 N PHE D 441
SHEET 4 AD2 4 ILE D 483 ALA D 488 -1 O GLU D 485 N THR D 458
SHEET 1 AD3 4 TRP D 505 ASN D 507 0
SHEET 2 AD3 4 LEU D 512 GLY D 517 -1 O TYR D 514 N TRP D 505
SHEET 3 AD3 4 HIS D 526 SER D 531 -1 O VAL D 530 N VAL D 513
SHEET 4 AD3 4 VAL D 539 ARG D 540 -1 O VAL D 539 N VAL D 529
SHEET 1 AD4 4 SER D 547 MET D 552 0
SHEET 2 AD4 4 MET D 558 SER D 564 -1 O HIS D 562 N SER D 549
SHEET 3 AD4 4 CYS D 571 SER D 578 -1 O HIS D 573 N SER D 561
SHEET 4 AD4 4 GLN D 588 MET D 596 -1 O MET D 595 N VAL D 572
SHEET 1 AD5 8 GLU D 609 HIS D 614 0
SHEET 2 AD5 8 ARG D 620 TYR D 626 -1 O GLY D 623 N PHE D 611
SHEET 3 AD5 8 ALA D 673 ASP D 678 -1 O VAL D 676 N MET D 624
SHEET 4 AD5 8 HIS D 637 VAL D 643 1 N VAL D 640 O ALA D 673
SHEET 5 AD5 8 ILE D 719 GLY D 728 1 O ALA D 725 N LEU D 641
SHEET 6 AD5 8 VAL D 749 GLY D 753 1 O GLY D 753 N GLY D 728
SHEET 7 AD5 8 LEU D 800 GLY D 805 1 O LEU D 803 N ALA D 752
SHEET 8 AD5 8 GLN D 831 TYR D 835 1 O GLN D 831 N ILE D 802
SHEET 1 AD6 2 CYS E1116 VAL E1118 0
SHEET 2 AD6 2 ALA E1163 HIS E1165 -1 O ALA E1163 N VAL E1118
SHEET 1 AD7 2 ARG E1199 VAL E1200 0
SHEET 2 AD7 2 ILE E1205 VAL E1206 -1 O VAL E1206 N ARG E1199
SHEET 1 AD8 2 PRO I1230 VAL I1231 0
SHEET 2 AD8 2 LEU I1284 TYR I1285 -1 O LEU I1284 N VAL I1231
SHEET 1 AD9 3 LEU I1237 TYR I1238 0
SHEET 2 AD9 3 THR I1247 TYR I1251 -1 O HIS I1249 N TYR I1238
SHEET 3 AD9 3 PHE I1320 TYR I1324 -1 O PHE I1323 N PHE I1248
SHEET 1 AE1 3 TYR I1290 GLY I1294 0
SHEET 2 AE1 3 LEU I1334 ASP I1338 -1 O LYS I1337 N THR I1291
SHEET 3 AE1 3 LEU I1344 TRP I1346 -1 O VAL I1345 N VAL I1336
SHEET 1 AE2 5 VAL F1273 ARG F1274 0
SHEET 2 AE2 5 TYR F1238 ARG F1240 -1 N HIS F1239 O VAL F1273
SHEET 3 AE2 5 VAL F1246 LEU F1250 -1 O HIS F1249 N TYR F1238
SHEET 4 AE2 5 SER F1321 GLY F1326 -1 O VAL F1325 N VAL F1246
SHEET 5 AE2 5 GLU F1301 ILE F1302 -1 N GLU F1301 O TYR F1324
SHEET 1 AE3 3 TYR F1290 SER F1293 0
SHEET 2 AE3 3 ARG F1333 ASP F1338 -1 O LYS F1337 N THR F1291
SHEET 3 AE3 3 LEU F1344 LEU F1349 -1 O TRP F1346 N VAL F1336
CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1
ORIGX1 1.000000 0.000000 0.000000 0.00000
ORIGX2 0.000000 1.000000 0.000000 0.00000
ORIGX3 0.000000 0.000000 1.000000 0.00000
SCALE1 1.000000 0.000000 0.000000 0.00000
SCALE2 0.000000 1.000000 0.000000 0.00000
SCALE3 0.000000 0.000000 1.000000 0.00000
TER 6817 LEU A 863
TER 7886 PHE B1212
TER 8994 VAL G1350
TER 10131 MET C1356
TER 16948 LEU D 863
TER 18002 PHE E1212
TER 19106 VAL I1350
TER 20248 MET F1356
MASTER 2875 0 0 48 152 0 0 620240 8 0 406
END |