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HEADER IMMUNE SYSTEM 27-MAY-20 6X6C
TITLE CRYO-EM STRUCTURE OF NLRP1-DPP9-VBP COMPLEX
COMPND MOL_ID: 1;
COMPND 2 MOLECULE: DIPEPTIDYL PEPTIDASE 9;
COMPND 3 CHAIN: A, D;
COMPND 4 SYNONYM: DP9,DIPEPTIDYL PEPTIDASE IV-RELATED PROTEIN 2,DPRP-2,
COMPND 5 DIPEPTIDYL PEPTIDASE IX,DPP IX,DIPEPTIDYL PEPTIDASE-LIKE PROTEIN 9,
COMPND 6 DPLP9;
COMPND 7 EC: 3.4.14.5;
COMPND 8 ENGINEERED: YES;
COMPND 9 MOL_ID: 2;
COMPND 10 MOLECULE: NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1;
COMPND 11 CHAIN: E, F;
COMPND 12 SYNONYM: CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 7,DEATH
COMPND 13 EFFECTOR FILAMENT-FORMING CED-4-LIKE APOPTOSIS PROTEIN,NUCLEOTIDE-
COMPND 14 BINDING DOMAIN AND CASPASE RECRUITMENT DOMAIN;
COMPND 15 ENGINEERED: YES
SOURCE MOL_ID: 1;
SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 3 ORGANISM_COMMON: HUMAN;
SOURCE 4 ORGANISM_TAXID: 9606;
SOURCE 5 GENE: DPP9, DPRP2;
SOURCE 6 EXPRESSION_SYSTEM: HOMO SAPIENS;
SOURCE 7 EXPRESSION_SYSTEM_COMMON: HUMAN;
SOURCE 8 EXPRESSION_SYSTEM_TAXID: 9606;
SOURCE 9 EXPRESSION_SYSTEM_CELL_LINE: HEK293T;
SOURCE 10 MOL_ID: 2;
SOURCE 11 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 12 ORGANISM_COMMON: HUMAN;
SOURCE 13 ORGANISM_TAXID: 9606;
SOURCE 14 GENE: NLRP1, CARD7, DEFCAP, KIAA0926, NAC, NALP1;
SOURCE 15 EXPRESSION_SYSTEM: HOMO SAPIENS;
SOURCE 16 EXPRESSION_SYSTEM_TAXID: 9606;
SOURCE 17 EXPRESSION_SYSTEM_CELL_LINE: HEK293T
KEYWDS NLRP1, DPP9, INFLAMMASOME, VAL-BOROPRO (VBP), TALABOSTAT, INNATE
KEYWDS 2 IMMUNITY, IMMUNE SYSTEM
EXPDTA ELECTRON MICROSCOPY
AUTHOR L.R.HOLLINGSWORTH,H.SHARIF
REVDAT 1 10-MAR-21 6X6C 0
JRNL AUTH L.R.HOLLINGSWORTH,H.SHARIF
JRNL TITL IMMUNE SYSTEM
JRNL REF TO BE PUBLISHED
JRNL REFN
REMARK 2
REMARK 2 RESOLUTION. 2.90 ANGSTROMS.
REMARK 3
REMARK 3 REFINEMENT.
REMARK 3 SOFTWARE PACKAGES : SERIALEM, CTFFIND, RELION, RELION,
REMARK 3 RELION, RELION
REMARK 3 RECONSTRUCTION SCHEMA : FOURIER SPACE
REMARK 3
REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT
REMARK 3 PDB ENTRY : NULL
REMARK 3 REFINEMENT SPACE : NULL
REMARK 3 REFINEMENT PROTOCOL : NULL
REMARK 3 REFINEMENT TARGET : NULL
REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL
REMARK 3
REMARK 3 FITTING PROCEDURE : NULL
REMARK 3
REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS
REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 2.900
REMARK 3 NUMBER OF PARTICLES : 205538
REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE
REMARK 3 CORRECTION
REMARK 3
REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL
REMARK 3
REMARK 3 OTHER DETAILS: NULL
REMARK 4
REMARK 4 6X6C COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 02-JUN-20.
REMARK 100 THE DEPOSITION ID IS D_1000249676.
REMARK 245
REMARK 245 EXPERIMENTAL DETAILS
REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE
REMARK 245 SPECIMEN TYPE : NULL
REMARK 245
REMARK 245 ELECTRON MICROSCOPE SAMPLE
REMARK 245 SAMPLE TYPE : PARTICLE
REMARK 245 PARTICLE TYPE : POINT
REMARK 245 NAME OF SAMPLE : DPP9-NLRP1 COMPLEX
REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 0.50
REMARK 245 SAMPLE SUPPORT DETAILS : NULL
REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL
REMARK 245 SAMPLE BUFFER : NULL
REMARK 245 PH : 7.50
REMARK 245 SAMPLE DETAILS : NULL
REMARK 245
REMARK 245 DATA ACQUISITION
REMARK 245 DATE OF EXPERIMENT : NULL
REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : 1954
REMARK 245 TEMPERATURE (KELVIN) : NULL
REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS
REMARK 245 DETECTOR TYPE : GATAN K3 BIOQUANTUM (6K X
REMARK 245 4K)
REMARK 245 MINIMUM DEFOCUS (NM) : -800.00
REMARK 245 MAXIMUM DEFOCUS (NM) : 2200.00
REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 NOMINAL CS : 2.70
REMARK 245 IMAGING MODE : OTHER
REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 65.00
REMARK 245 ILLUMINATION MODE : SPOT SCAN
REMARK 245 NOMINAL MAGNIFICATION : NULL
REMARK 245 CALIBRATED MAGNIFICATION : 10500
REMARK 245 SOURCE : OTHER
REMARK 245 ACCELERATION VOLTAGE (KV) : 300
REMARK 245 IMAGING DETAILS : NULL
REMARK 247
REMARK 247 ELECTRON MICROSCOPY
REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON
REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE
REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES
REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION
REMARK 247 OF THE STRUCTURE FACTORS.
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, D, E, F
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465 M RES C SSSEQI
REMARK 465 MET A -27
REMARK 465 SER A -26
REMARK 465 TYR A -25
REMARK 465 TYR A -24
REMARK 465 HIS A -23
REMARK 465 HIS A -22
REMARK 465 HIS A -21
REMARK 465 HIS A -20
REMARK 465 HIS A -19
REMARK 465 HIS A -18
REMARK 465 ASP A -17
REMARK 465 TYR A -16
REMARK 465 ASP A -15
REMARK 465 ILE A -14
REMARK 465 PRO A -13
REMARK 465 THR A -12
REMARK 465 THR A -11
REMARK 465 GLU A -10
REMARK 465 ASN A -9
REMARK 465 LEU A -8
REMARK 465 TYR A -7
REMARK 465 PHE A -6
REMARK 465 GLN A -5
REMARK 465 GLY A -4
REMARK 465 ALA A -3
REMARK 465 MET A -2
REMARK 465 GLY A -1
REMARK 465 SER A 0
REMARK 465 MET A 1
REMARK 465 ALA A 2
REMARK 465 THR A 3
REMARK 465 THR A 4
REMARK 465 GLY A 5
REMARK 465 THR A 6
REMARK 465 PRO A 7
REMARK 465 THR A 8
REMARK 465 ALA A 9
REMARK 465 ASP A 10
REMARK 465 ARG A 11
REMARK 465 GLY A 12
REMARK 465 ASP A 13
REMARK 465 ALA A 14
REMARK 465 ALA A 15
REMARK 465 ALA A 16
REMARK 465 THR A 17
REMARK 465 MET D -27
REMARK 465 SER D -26
REMARK 465 TYR D -25
REMARK 465 TYR D -24
REMARK 465 HIS D -23
REMARK 465 HIS D -22
REMARK 465 HIS D -21
REMARK 465 HIS D -20
REMARK 465 HIS D -19
REMARK 465 HIS D -18
REMARK 465 ASP D -17
REMARK 465 TYR D -16
REMARK 465 ASP D -15
REMARK 465 ILE D -14
REMARK 465 PRO D -13
REMARK 465 THR D -12
REMARK 465 THR D -11
REMARK 465 GLU D -10
REMARK 465 ASN D -9
REMARK 465 LEU D -8
REMARK 465 TYR D -7
REMARK 465 PHE D -6
REMARK 465 GLN D -5
REMARK 465 GLY D -4
REMARK 465 ALA D -3
REMARK 465 MET D -2
REMARK 465 GLY D -1
REMARK 465 SER D 0
REMARK 465 MET D 1
REMARK 465 ALA D 2
REMARK 465 THR D 3
REMARK 465 THR D 4
REMARK 465 GLY D 5
REMARK 465 THR D 6
REMARK 465 PRO D 7
REMARK 465 THR D 8
REMARK 465 ALA D 9
REMARK 465 ASP D 10
REMARK 465 ARG D 11
REMARK 465 GLY D 12
REMARK 465 ASP D 13
REMARK 465 ALA D 14
REMARK 465 ALA D 15
REMARK 465 ALA D 16
REMARK 465 THR D 17
REMARK 465 MET E 1
REMARK 465 ALA E 2
REMARK 465 GLY E 3
REMARK 465 GLY E 4
REMARK 465 ALA E 5
REMARK 465 TRP E 6
REMARK 465 GLY E 7
REMARK 465 ARG E 8
REMARK 465 LEU E 9
REMARK 465 ALA E 10
REMARK 465 CYS E 11
REMARK 465 TYR E 12
REMARK 465 LEU E 13
REMARK 465 GLU E 14
REMARK 465 PHE E 15
REMARK 465 LEU E 16
REMARK 465 LYS E 17
REMARK 465 LYS E 18
REMARK 465 GLU E 19
REMARK 465 GLU E 20
REMARK 465 LEU E 21
REMARK 465 LYS E 22
REMARK 465 GLU E 23
REMARK 465 PHE E 24
REMARK 465 GLN E 25
REMARK 465 LEU E 26
REMARK 465 LEU E 27
REMARK 465 LEU E 28
REMARK 465 ALA E 29
REMARK 465 ASN E 30
REMARK 465 LYS E 31
REMARK 465 ALA E 32
REMARK 465 HIS E 33
REMARK 465 SER E 34
REMARK 465 ARG E 35
REMARK 465 SER E 36
REMARK 465 SER E 37
REMARK 465 SER E 38
REMARK 465 GLY E 39
REMARK 465 GLU E 40
REMARK 465 THR E 41
REMARK 465 PRO E 42
REMARK 465 ALA E 43
REMARK 465 GLN E 44
REMARK 465 PRO E 45
REMARK 465 GLU E 46
REMARK 465 LYS E 47
REMARK 465 THR E 48
REMARK 465 SER E 49
REMARK 465 GLY E 50
REMARK 465 MET E 51
REMARK 465 GLU E 52
REMARK 465 VAL E 53
REMARK 465 ALA E 54
REMARK 465 SER E 55
REMARK 465 TYR E 56
REMARK 465 LEU E 57
REMARK 465 VAL E 58
REMARK 465 ALA E 59
REMARK 465 GLN E 60
REMARK 465 TYR E 61
REMARK 465 GLY E 62
REMARK 465 GLU E 63
REMARK 465 GLN E 64
REMARK 465 ARG E 65
REMARK 465 ALA E 66
REMARK 465 TRP E 67
REMARK 465 ASP E 68
REMARK 465 LEU E 69
REMARK 465 ALA E 70
REMARK 465 LEU E 71
REMARK 465 HIS E 72
REMARK 465 THR E 73
REMARK 465 TRP E 74
REMARK 465 GLU E 75
REMARK 465 GLN E 76
REMARK 465 MET E 77
REMARK 465 GLY E 78
REMARK 465 LEU E 79
REMARK 465 ARG E 80
REMARK 465 SER E 81
REMARK 465 LEU E 82
REMARK 465 CYS E 83
REMARK 465 ALA E 84
REMARK 465 GLN E 85
REMARK 465 ALA E 86
REMARK 465 GLN E 87
REMARK 465 GLU E 88
REMARK 465 GLY E 89
REMARK 465 ALA E 90
REMARK 465 GLY E 91
REMARK 465 HIS E 92
REMARK 465 SER E 93
REMARK 465 PRO E 94
REMARK 465 SER E 95
REMARK 465 PHE E 96
REMARK 465 PRO E 97
REMARK 465 TYR E 98
REMARK 465 SER E 99
REMARK 465 PRO E 100
REMARK 465 SER E 101
REMARK 465 GLU E 102
REMARK 465 PRO E 103
REMARK 465 HIS E 104
REMARK 465 LEU E 105
REMARK 465 GLY E 106
REMARK 465 SER E 107
REMARK 465 PRO E 108
REMARK 465 SER E 109
REMARK 465 GLN E 110
REMARK 465 PRO E 111
REMARK 465 THR E 112
REMARK 465 SER E 113
REMARK 465 THR E 114
REMARK 465 ALA E 115
REMARK 465 VAL E 116
REMARK 465 LEU E 117
REMARK 465 MET E 118
REMARK 465 PRO E 119
REMARK 465 TRP E 120
REMARK 465 ILE E 121
REMARK 465 HIS E 122
REMARK 465 GLU E 123
REMARK 465 LEU E 124
REMARK 465 PRO E 125
REMARK 465 ALA E 126
REMARK 465 GLY E 127
REMARK 465 CYS E 128
REMARK 465 THR E 129
REMARK 465 GLN E 130
REMARK 465 GLY E 131
REMARK 465 SER E 132
REMARK 465 GLU E 133
REMARK 465 ARG E 134
REMARK 465 ARG E 135
REMARK 465 VAL E 136
REMARK 465 LEU E 137
REMARK 465 ARG E 138
REMARK 465 GLN E 139
REMARK 465 LEU E 140
REMARK 465 PRO E 141
REMARK 465 ASP E 142
REMARK 465 THR E 143
REMARK 465 SER E 144
REMARK 465 GLY E 145
REMARK 465 ARG E 146
REMARK 465 ARG E 147
REMARK 465 TRP E 148
REMARK 465 ARG E 149
REMARK 465 GLU E 150
REMARK 465 ILE E 151
REMARK 465 SER E 152
REMARK 465 ALA E 153
REMARK 465 SER E 154
REMARK 465 LEU E 155
REMARK 465 LEU E 156
REMARK 465 TYR E 157
REMARK 465 GLN E 158
REMARK 465 ALA E 159
REMARK 465 LEU E 160
REMARK 465 PRO E 161
REMARK 465 SER E 162
REMARK 465 SER E 163
REMARK 465 PRO E 164
REMARK 465 ASP E 165
REMARK 465 HIS E 166
REMARK 465 GLU E 167
REMARK 465 SER E 168
REMARK 465 PRO E 169
REMARK 465 SER E 170
REMARK 465 GLN E 171
REMARK 465 GLU E 172
REMARK 465 SER E 173
REMARK 465 PRO E 174
REMARK 465 ASN E 175
REMARK 465 ALA E 176
REMARK 465 PRO E 177
REMARK 465 THR E 178
REMARK 465 SER E 179
REMARK 465 THR E 180
REMARK 465 ALA E 181
REMARK 465 VAL E 182
REMARK 465 LEU E 183
REMARK 465 GLY E 184
REMARK 465 SER E 185
REMARK 465 TRP E 186
REMARK 465 GLY E 187
REMARK 465 SER E 188
REMARK 465 PRO E 189
REMARK 465 PRO E 190
REMARK 465 GLN E 191
REMARK 465 PRO E 192
REMARK 465 SER E 193
REMARK 465 LEU E 194
REMARK 465 ALA E 195
REMARK 465 PRO E 196
REMARK 465 ARG E 197
REMARK 465 GLU E 198
REMARK 465 GLN E 199
REMARK 465 GLU E 200
REMARK 465 ALA E 201
REMARK 465 PRO E 202
REMARK 465 GLY E 203
REMARK 465 THR E 204
REMARK 465 GLN E 205
REMARK 465 TRP E 206
REMARK 465 PRO E 207
REMARK 465 LEU E 208
REMARK 465 ASP E 209
REMARK 465 GLU E 210
REMARK 465 THR E 211
REMARK 465 SER E 212
REMARK 465 GLY E 213
REMARK 465 ILE E 214
REMARK 465 TYR E 215
REMARK 465 TYR E 216
REMARK 465 THR E 217
REMARK 465 GLU E 218
REMARK 465 ILE E 219
REMARK 465 ARG E 220
REMARK 465 GLU E 221
REMARK 465 ARG E 222
REMARK 465 GLU E 223
REMARK 465 ARG E 224
REMARK 465 GLU E 225
REMARK 465 LYS E 226
REMARK 465 SER E 227
REMARK 465 GLU E 228
REMARK 465 LYS E 229
REMARK 465 GLY E 230
REMARK 465 ARG E 231
REMARK 465 PRO E 232
REMARK 465 PRO E 233
REMARK 465 TRP E 234
REMARK 465 ALA E 235
REMARK 465 ALA E 236
REMARK 465 VAL E 237
REMARK 465 VAL E 238
REMARK 465 GLY E 239
REMARK 465 THR E 240
REMARK 465 PRO E 241
REMARK 465 PRO E 242
REMARK 465 GLN E 243
REMARK 465 ALA E 244
REMARK 465 HIS E 245
REMARK 465 THR E 246
REMARK 465 SER E 247
REMARK 465 LEU E 248
REMARK 465 GLN E 249
REMARK 465 PRO E 250
REMARK 465 HIS E 251
REMARK 465 HIS E 252
REMARK 465 HIS E 253
REMARK 465 PRO E 254
REMARK 465 TRP E 255
REMARK 465 GLU E 256
REMARK 465 PRO E 257
REMARK 465 SER E 258
REMARK 465 VAL E 259
REMARK 465 ARG E 260
REMARK 465 GLU E 261
REMARK 465 SER E 262
REMARK 465 LEU E 263
REMARK 465 CYS E 264
REMARK 465 SER E 265
REMARK 465 THR E 266
REMARK 465 TRP E 267
REMARK 465 PRO E 268
REMARK 465 TRP E 269
REMARK 465 LYS E 270
REMARK 465 ASN E 271
REMARK 465 GLU E 272
REMARK 465 ASP E 273
REMARK 465 PHE E 274
REMARK 465 ASN E 275
REMARK 465 GLN E 276
REMARK 465 LYS E 277
REMARK 465 PHE E 278
REMARK 465 THR E 279
REMARK 465 GLN E 280
REMARK 465 LEU E 281
REMARK 465 LEU E 282
REMARK 465 LEU E 283
REMARK 465 LEU E 284
REMARK 465 GLN E 285
REMARK 465 ARG E 286
REMARK 465 PRO E 287
REMARK 465 HIS E 288
REMARK 465 PRO E 289
REMARK 465 ARG E 290
REMARK 465 SER E 291
REMARK 465 GLN E 292
REMARK 465 ASP E 293
REMARK 465 PRO E 294
REMARK 465 LEU E 295
REMARK 465 VAL E 296
REMARK 465 LYS E 297
REMARK 465 ARG E 298
REMARK 465 SER E 299
REMARK 465 TRP E 300
REMARK 465 PRO E 301
REMARK 465 ASP E 302
REMARK 465 TYR E 303
REMARK 465 VAL E 304
REMARK 465 GLU E 305
REMARK 465 GLU E 306
REMARK 465 ASN E 307
REMARK 465 ARG E 308
REMARK 465 GLY E 309
REMARK 465 HIS E 310
REMARK 465 LEU E 311
REMARK 465 ILE E 312
REMARK 465 GLU E 313
REMARK 465 ILE E 314
REMARK 465 ARG E 315
REMARK 465 ASP E 316
REMARK 465 LEU E 317
REMARK 465 PHE E 318
REMARK 465 GLY E 319
REMARK 465 PRO E 320
REMARK 465 GLY E 321
REMARK 465 LEU E 322
REMARK 465 ASP E 323
REMARK 465 THR E 324
REMARK 465 GLN E 325
REMARK 465 GLU E 326
REMARK 465 PRO E 327
REMARK 465 ARG E 328
REMARK 465 ILE E 329
REMARK 465 VAL E 330
REMARK 465 ILE E 331
REMARK 465 LEU E 332
REMARK 465 GLN E 333
REMARK 465 GLY E 334
REMARK 465 ALA E 335
REMARK 465 ALA E 336
REMARK 465 GLY E 337
REMARK 465 ILE E 338
REMARK 465 GLY E 339
REMARK 465 LYS E 340
REMARK 465 SER E 341
REMARK 465 THR E 342
REMARK 465 LEU E 343
REMARK 465 ALA E 344
REMARK 465 ARG E 345
REMARK 465 GLN E 346
REMARK 465 VAL E 347
REMARK 465 LYS E 348
REMARK 465 GLU E 349
REMARK 465 ALA E 350
REMARK 465 TRP E 351
REMARK 465 GLY E 352
REMARK 465 ARG E 353
REMARK 465 GLY E 354
REMARK 465 GLN E 355
REMARK 465 LEU E 356
REMARK 465 TYR E 357
REMARK 465 GLY E 358
REMARK 465 ASP E 359
REMARK 465 ARG E 360
REMARK 465 PHE E 361
REMARK 465 GLN E 362
REMARK 465 HIS E 363
REMARK 465 VAL E 364
REMARK 465 PHE E 365
REMARK 465 TYR E 366
REMARK 465 PHE E 367
REMARK 465 SER E 368
REMARK 465 CYS E 369
REMARK 465 ARG E 370
REMARK 465 GLU E 371
REMARK 465 LEU E 372
REMARK 465 ALA E 373
REMARK 465 GLN E 374
REMARK 465 SER E 375
REMARK 465 LYS E 376
REMARK 465 VAL E 377
REMARK 465 VAL E 378
REMARK 465 SER E 379
REMARK 465 LEU E 380
REMARK 465 ALA E 381
REMARK 465 GLU E 382
REMARK 465 LEU E 383
REMARK 465 ILE E 384
REMARK 465 GLY E 385
REMARK 465 LYS E 386
REMARK 465 ASP E 387
REMARK 465 GLY E 388
REMARK 465 THR E 389
REMARK 465 ALA E 390
REMARK 465 THR E 391
REMARK 465 PRO E 392
REMARK 465 ALA E 393
REMARK 465 PRO E 394
REMARK 465 ILE E 395
REMARK 465 ARG E 396
REMARK 465 GLN E 397
REMARK 465 ILE E 398
REMARK 465 LEU E 399
REMARK 465 SER E 400
REMARK 465 ARG E 401
REMARK 465 PRO E 402
REMARK 465 GLU E 403
REMARK 465 ARG E 404
REMARK 465 LEU E 405
REMARK 465 LEU E 406
REMARK 465 PHE E 407
REMARK 465 ILE E 408
REMARK 465 LEU E 409
REMARK 465 ASP E 410
REMARK 465 GLY E 411
REMARK 465 VAL E 412
REMARK 465 ASP E 413
REMARK 465 GLU E 414
REMARK 465 PRO E 415
REMARK 465 GLY E 416
REMARK 465 TRP E 417
REMARK 465 VAL E 418
REMARK 465 LEU E 419
REMARK 465 GLN E 420
REMARK 465 GLU E 421
REMARK 465 PRO E 422
REMARK 465 SER E 423
REMARK 465 SER E 424
REMARK 465 GLU E 425
REMARK 465 LEU E 426
REMARK 465 CYS E 427
REMARK 465 LEU E 428
REMARK 465 HIS E 429
REMARK 465 TRP E 430
REMARK 465 SER E 431
REMARK 465 GLN E 432
REMARK 465 PRO E 433
REMARK 465 GLN E 434
REMARK 465 PRO E 435
REMARK 465 ALA E 436
REMARK 465 ASP E 437
REMARK 465 ALA E 438
REMARK 465 LEU E 439
REMARK 465 LEU E 440
REMARK 465 GLY E 441
REMARK 465 SER E 442
REMARK 465 LEU E 443
REMARK 465 LEU E 444
REMARK 465 GLY E 445
REMARK 465 LYS E 446
REMARK 465 THR E 447
REMARK 465 ILE E 448
REMARK 465 LEU E 449
REMARK 465 PRO E 450
REMARK 465 GLU E 451
REMARK 465 ALA E 452
REMARK 465 SER E 453
REMARK 465 PHE E 454
REMARK 465 LEU E 455
REMARK 465 ILE E 456
REMARK 465 THR E 457
REMARK 465 ALA E 458
REMARK 465 ARG E 459
REMARK 465 THR E 460
REMARK 465 THR E 461
REMARK 465 ALA E 462
REMARK 465 LEU E 463
REMARK 465 GLN E 464
REMARK 465 ASN E 465
REMARK 465 LEU E 466
REMARK 465 ILE E 467
REMARK 465 PRO E 468
REMARK 465 SER E 469
REMARK 465 LEU E 470
REMARK 465 GLU E 471
REMARK 465 GLN E 472
REMARK 465 ALA E 473
REMARK 465 ARG E 474
REMARK 465 TRP E 475
REMARK 465 VAL E 476
REMARK 465 GLU E 477
REMARK 465 VAL E 478
REMARK 465 LEU E 479
REMARK 465 GLY E 480
REMARK 465 PHE E 481
REMARK 465 SER E 482
REMARK 465 GLU E 483
REMARK 465 SER E 484
REMARK 465 SER E 485
REMARK 465 ARG E 486
REMARK 465 LYS E 487
REMARK 465 GLU E 488
REMARK 465 TYR E 489
REMARK 465 PHE E 490
REMARK 465 TYR E 491
REMARK 465 ARG E 492
REMARK 465 TYR E 493
REMARK 465 PHE E 494
REMARK 465 THR E 495
REMARK 465 ASP E 496
REMARK 465 GLU E 497
REMARK 465 ARG E 498
REMARK 465 GLN E 499
REMARK 465 ALA E 500
REMARK 465 ILE E 501
REMARK 465 ARG E 502
REMARK 465 ALA E 503
REMARK 465 PHE E 504
REMARK 465 ARG E 505
REMARK 465 LEU E 506
REMARK 465 VAL E 507
REMARK 465 LYS E 508
REMARK 465 SER E 509
REMARK 465 ASN E 510
REMARK 465 LYS E 511
REMARK 465 GLU E 512
REMARK 465 LEU E 513
REMARK 465 TRP E 514
REMARK 465 ALA E 515
REMARK 465 LEU E 516
REMARK 465 CYS E 517
REMARK 465 LEU E 518
REMARK 465 VAL E 519
REMARK 465 PRO E 520
REMARK 465 TRP E 521
REMARK 465 VAL E 522
REMARK 465 SER E 523
REMARK 465 TRP E 524
REMARK 465 LEU E 525
REMARK 465 ALA E 526
REMARK 465 CYS E 527
REMARK 465 THR E 528
REMARK 465 CYS E 529
REMARK 465 LEU E 530
REMARK 465 MET E 531
REMARK 465 GLN E 532
REMARK 465 GLN E 533
REMARK 465 MET E 534
REMARK 465 LYS E 535
REMARK 465 ARG E 536
REMARK 465 LYS E 537
REMARK 465 GLU E 538
REMARK 465 LYS E 539
REMARK 465 LEU E 540
REMARK 465 THR E 541
REMARK 465 LEU E 542
REMARK 465 THR E 543
REMARK 465 SER E 544
REMARK 465 LYS E 545
REMARK 465 THR E 546
REMARK 465 THR E 547
REMARK 465 THR E 548
REMARK 465 THR E 549
REMARK 465 LEU E 550
REMARK 465 CYS E 551
REMARK 465 LEU E 552
REMARK 465 HIS E 553
REMARK 465 TYR E 554
REMARK 465 LEU E 555
REMARK 465 ALA E 556
REMARK 465 GLN E 557
REMARK 465 ALA E 558
REMARK 465 LEU E 559
REMARK 465 GLN E 560
REMARK 465 ALA E 561
REMARK 465 GLN E 562
REMARK 465 PRO E 563
REMARK 465 LEU E 564
REMARK 465 GLY E 565
REMARK 465 PRO E 566
REMARK 465 GLN E 567
REMARK 465 LEU E 568
REMARK 465 ARG E 569
REMARK 465 ASP E 570
REMARK 465 LEU E 571
REMARK 465 CYS E 572
REMARK 465 SER E 573
REMARK 465 LEU E 574
REMARK 465 ALA E 575
REMARK 465 ALA E 576
REMARK 465 GLU E 577
REMARK 465 GLY E 578
REMARK 465 ILE E 579
REMARK 465 TRP E 580
REMARK 465 GLN E 581
REMARK 465 LYS E 582
REMARK 465 LYS E 583
REMARK 465 THR E 584
REMARK 465 LEU E 585
REMARK 465 PHE E 586
REMARK 465 SER E 587
REMARK 465 PRO E 588
REMARK 465 ASP E 589
REMARK 465 ASP E 590
REMARK 465 LEU E 591
REMARK 465 ARG E 592
REMARK 465 LYS E 593
REMARK 465 HIS E 594
REMARK 465 GLY E 595
REMARK 465 LEU E 596
REMARK 465 ASP E 597
REMARK 465 GLY E 598
REMARK 465 ALA E 599
REMARK 465 ILE E 600
REMARK 465 ILE E 601
REMARK 465 SER E 602
REMARK 465 THR E 603
REMARK 465 PHE E 604
REMARK 465 LEU E 605
REMARK 465 LYS E 606
REMARK 465 MET E 607
REMARK 465 GLY E 608
REMARK 465 ILE E 609
REMARK 465 LEU E 610
REMARK 465 GLN E 611
REMARK 465 GLU E 612
REMARK 465 HIS E 613
REMARK 465 PRO E 614
REMARK 465 ILE E 615
REMARK 465 PRO E 616
REMARK 465 LEU E 617
REMARK 465 SER E 618
REMARK 465 TYR E 619
REMARK 465 SER E 620
REMARK 465 PHE E 621
REMARK 465 ILE E 622
REMARK 465 HIS E 623
REMARK 465 LEU E 624
REMARK 465 CYS E 625
REMARK 465 PHE E 626
REMARK 465 GLN E 627
REMARK 465 GLU E 628
REMARK 465 PHE E 629
REMARK 465 PHE E 630
REMARK 465 ALA E 631
REMARK 465 ALA E 632
REMARK 465 MET E 633
REMARK 465 SER E 634
REMARK 465 TYR E 635
REMARK 465 VAL E 636
REMARK 465 LEU E 637
REMARK 465 GLU E 638
REMARK 465 ASP E 639
REMARK 465 GLU E 640
REMARK 465 LYS E 641
REMARK 465 GLY E 642
REMARK 465 ARG E 643
REMARK 465 GLY E 644
REMARK 465 LYS E 645
REMARK 465 HIS E 646
REMARK 465 SER E 647
REMARK 465 ASN E 648
REMARK 465 CYS E 649
REMARK 465 ILE E 650
REMARK 465 ILE E 651
REMARK 465 ASP E 652
REMARK 465 LEU E 653
REMARK 465 GLU E 654
REMARK 465 LYS E 655
REMARK 465 THR E 656
REMARK 465 LEU E 657
REMARK 465 GLU E 658
REMARK 465 ALA E 659
REMARK 465 TYR E 660
REMARK 465 GLY E 661
REMARK 465 ILE E 662
REMARK 465 HIS E 663
REMARK 465 GLY E 664
REMARK 465 LEU E 665
REMARK 465 PHE E 666
REMARK 465 GLY E 667
REMARK 465 ALA E 668
REMARK 465 SER E 669
REMARK 465 THR E 670
REMARK 465 THR E 671
REMARK 465 ARG E 672
REMARK 465 PHE E 673
REMARK 465 LEU E 674
REMARK 465 LEU E 675
REMARK 465 GLY E 676
REMARK 465 LEU E 677
REMARK 465 LEU E 678
REMARK 465 SER E 679
REMARK 465 ASP E 680
REMARK 465 GLU E 681
REMARK 465 GLY E 682
REMARK 465 GLU E 683
REMARK 465 ARG E 684
REMARK 465 GLU E 685
REMARK 465 MET E 686
REMARK 465 GLU E 687
REMARK 465 ASN E 688
REMARK 465 ILE E 689
REMARK 465 PHE E 690
REMARK 465 HIS E 691
REMARK 465 CYS E 692
REMARK 465 ARG E 693
REMARK 465 LEU E 694
REMARK 465 SER E 695
REMARK 465 GLN E 696
REMARK 465 GLY E 697
REMARK 465 ARG E 698
REMARK 465 ASN E 699
REMARK 465 LEU E 700
REMARK 465 MET E 701
REMARK 465 GLN E 702
REMARK 465 TRP E 703
REMARK 465 VAL E 704
REMARK 465 PRO E 705
REMARK 465 SER E 706
REMARK 465 LEU E 707
REMARK 465 GLN E 708
REMARK 465 LEU E 709
REMARK 465 LEU E 710
REMARK 465 LEU E 711
REMARK 465 GLN E 712
REMARK 465 PRO E 713
REMARK 465 HIS E 714
REMARK 465 SER E 715
REMARK 465 LEU E 716
REMARK 465 GLU E 717
REMARK 465 SER E 718
REMARK 465 LEU E 719
REMARK 465 HIS E 720
REMARK 465 CYS E 721
REMARK 465 LEU E 722
REMARK 465 TYR E 723
REMARK 465 GLU E 724
REMARK 465 THR E 725
REMARK 465 ARG E 726
REMARK 465 ASN E 727
REMARK 465 LYS E 728
REMARK 465 THR E 729
REMARK 465 PHE E 730
REMARK 465 LEU E 731
REMARK 465 THR E 732
REMARK 465 GLN E 733
REMARK 465 VAL E 734
REMARK 465 MET E 735
REMARK 465 ALA E 736
REMARK 465 HIS E 737
REMARK 465 PHE E 738
REMARK 465 GLU E 739
REMARK 465 GLU E 740
REMARK 465 MET E 741
REMARK 465 GLY E 742
REMARK 465 MET E 743
REMARK 465 CYS E 744
REMARK 465 VAL E 745
REMARK 465 GLU E 746
REMARK 465 THR E 747
REMARK 465 ASP E 748
REMARK 465 MET E 749
REMARK 465 GLU E 750
REMARK 465 LEU E 751
REMARK 465 LEU E 752
REMARK 465 VAL E 753
REMARK 465 CYS E 754
REMARK 465 THR E 755
REMARK 465 PHE E 756
REMARK 465 CYS E 757
REMARK 465 ILE E 758
REMARK 465 LYS E 759
REMARK 465 PHE E 760
REMARK 465 SER E 761
REMARK 465 ARG E 762
REMARK 465 HIS E 763
REMARK 465 VAL E 764
REMARK 465 LYS E 765
REMARK 465 LYS E 766
REMARK 465 LEU E 767
REMARK 465 GLN E 768
REMARK 465 LEU E 769
REMARK 465 ILE E 770
REMARK 465 GLU E 771
REMARK 465 GLY E 772
REMARK 465 ARG E 773
REMARK 465 GLN E 774
REMARK 465 HIS E 775
REMARK 465 ARG E 776
REMARK 465 SER E 777
REMARK 465 THR E 778
REMARK 465 TRP E 779
REMARK 465 SER E 780
REMARK 465 PRO E 781
REMARK 465 THR E 782
REMARK 465 MET E 783
REMARK 465 VAL E 784
REMARK 465 VAL E 785
REMARK 465 LEU E 786
REMARK 465 PHE E 787
REMARK 465 ARG E 788
REMARK 465 TRP E 789
REMARK 465 VAL E 790
REMARK 465 PRO E 791
REMARK 465 VAL E 792
REMARK 465 THR E 793
REMARK 465 ASP E 794
REMARK 465 ALA E 795
REMARK 465 TYR E 796
REMARK 465 TRP E 797
REMARK 465 GLN E 798
REMARK 465 ILE E 799
REMARK 465 LEU E 800
REMARK 465 PHE E 801
REMARK 465 SER E 802
REMARK 465 VAL E 803
REMARK 465 LEU E 804
REMARK 465 LYS E 805
REMARK 465 VAL E 806
REMARK 465 THR E 807
REMARK 465 ARG E 808
REMARK 465 ASN E 809
REMARK 465 LEU E 810
REMARK 465 LYS E 811
REMARK 465 GLU E 812
REMARK 465 LEU E 813
REMARK 465 ASP E 814
REMARK 465 LEU E 815
REMARK 465 SER E 816
REMARK 465 GLY E 817
REMARK 465 ASN E 818
REMARK 465 SER E 819
REMARK 465 LEU E 820
REMARK 465 SER E 821
REMARK 465 HIS E 822
REMARK 465 SER E 823
REMARK 465 ALA E 824
REMARK 465 VAL E 825
REMARK 465 LYS E 826
REMARK 465 SER E 827
REMARK 465 LEU E 828
REMARK 465 CYS E 829
REMARK 465 LYS E 830
REMARK 465 THR E 831
REMARK 465 LEU E 832
REMARK 465 ARG E 833
REMARK 465 ARG E 834
REMARK 465 PRO E 835
REMARK 465 ARG E 836
REMARK 465 CYS E 837
REMARK 465 LEU E 838
REMARK 465 LEU E 839
REMARK 465 GLU E 840
REMARK 465 THR E 841
REMARK 465 LEU E 842
REMARK 465 ARG E 843
REMARK 465 LEU E 844
REMARK 465 ALA E 845
REMARK 465 GLY E 846
REMARK 465 CYS E 847
REMARK 465 GLY E 848
REMARK 465 LEU E 849
REMARK 465 THR E 850
REMARK 465 ALA E 851
REMARK 465 GLU E 852
REMARK 465 ASP E 853
REMARK 465 CYS E 854
REMARK 465 LYS E 855
REMARK 465 ASP E 856
REMARK 465 LEU E 857
REMARK 465 ALA E 858
REMARK 465 PHE E 859
REMARK 465 GLY E 860
REMARK 465 LEU E 861
REMARK 465 ARG E 862
REMARK 465 ALA E 863
REMARK 465 ASN E 864
REMARK 465 GLN E 865
REMARK 465 THR E 866
REMARK 465 LEU E 867
REMARK 465 THR E 868
REMARK 465 GLU E 869
REMARK 465 LEU E 870
REMARK 465 ASP E 871
REMARK 465 LEU E 872
REMARK 465 SER E 873
REMARK 465 PHE E 874
REMARK 465 ASN E 875
REMARK 465 VAL E 876
REMARK 465 LEU E 877
REMARK 465 THR E 878
REMARK 465 ASP E 879
REMARK 465 ALA E 880
REMARK 465 GLY E 881
REMARK 465 ALA E 882
REMARK 465 LYS E 883
REMARK 465 HIS E 884
REMARK 465 LEU E 885
REMARK 465 CYS E 886
REMARK 465 GLN E 887
REMARK 465 ARG E 888
REMARK 465 LEU E 889
REMARK 465 ARG E 890
REMARK 465 GLN E 891
REMARK 465 PRO E 892
REMARK 465 SER E 893
REMARK 465 CYS E 894
REMARK 465 LYS E 895
REMARK 465 LEU E 896
REMARK 465 GLN E 897
REMARK 465 ARG E 898
REMARK 465 LEU E 899
REMARK 465 GLN E 900
REMARK 465 LEU E 901
REMARK 465 VAL E 902
REMARK 465 SER E 903
REMARK 465 CYS E 904
REMARK 465 GLY E 905
REMARK 465 LEU E 906
REMARK 465 THR E 907
REMARK 465 SER E 908
REMARK 465 ASP E 909
REMARK 465 CYS E 910
REMARK 465 CYS E 911
REMARK 465 GLN E 912
REMARK 465 ASP E 913
REMARK 465 LEU E 914
REMARK 465 ALA E 915
REMARK 465 SER E 916
REMARK 465 VAL E 917
REMARK 465 LEU E 918
REMARK 465 SER E 919
REMARK 465 ALA E 920
REMARK 465 SER E 921
REMARK 465 PRO E 922
REMARK 465 SER E 923
REMARK 465 LEU E 924
REMARK 465 LYS E 925
REMARK 465 GLU E 926
REMARK 465 LEU E 927
REMARK 465 ASP E 928
REMARK 465 LEU E 929
REMARK 465 GLN E 930
REMARK 465 GLN E 931
REMARK 465 ASN E 932
REMARK 465 ASN E 933
REMARK 465 LEU E 934
REMARK 465 ASP E 935
REMARK 465 ASP E 936
REMARK 465 VAL E 937
REMARK 465 GLY E 938
REMARK 465 VAL E 939
REMARK 465 ARG E 940
REMARK 465 LEU E 941
REMARK 465 LEU E 942
REMARK 465 CYS E 943
REMARK 465 GLU E 944
REMARK 465 GLY E 945
REMARK 465 LEU E 946
REMARK 465 ARG E 947
REMARK 465 HIS E 948
REMARK 465 PRO E 949
REMARK 465 ALA E 950
REMARK 465 CYS E 951
REMARK 465 LYS E 952
REMARK 465 LEU E 953
REMARK 465 ILE E 954
REMARK 465 ARG E 955
REMARK 465 LEU E 956
REMARK 465 GLY E 957
REMARK 465 LEU E 958
REMARK 465 ASP E 959
REMARK 465 GLN E 960
REMARK 465 THR E 961
REMARK 465 THR E 962
REMARK 465 LEU E 963
REMARK 465 SER E 964
REMARK 465 ASP E 965
REMARK 465 GLU E 966
REMARK 465 MET E 967
REMARK 465 ARG E 968
REMARK 465 GLN E 969
REMARK 465 GLU E 970
REMARK 465 LEU E 971
REMARK 465 ARG E 972
REMARK 465 ALA E 973
REMARK 465 LEU E 974
REMARK 465 GLU E 975
REMARK 465 GLN E 976
REMARK 465 GLU E 977
REMARK 465 LYS E 978
REMARK 465 PRO E 979
REMARK 465 GLN E 980
REMARK 465 LEU E 981
REMARK 465 LEU E 982
REMARK 465 ILE E 983
REMARK 465 PHE E 984
REMARK 465 SER E 985
REMARK 465 ARG E 986
REMARK 465 ARG E 987
REMARK 465 LYS E 988
REMARK 465 PRO E 989
REMARK 465 SER E 990
REMARK 465 VAL E 991
REMARK 465 MET E 992
REMARK 465 THR E 993
REMARK 465 PRO E 994
REMARK 465 THR E 995
REMARK 465 GLU E 996
REMARK 465 GLY E 997
REMARK 465 LEU E 998
REMARK 465 ASP E 999
REMARK 465 THR E 1000
REMARK 465 GLY E 1001
REMARK 465 GLU E 1002
REMARK 465 MET E 1003
REMARK 465 SER E 1004
REMARK 465 ASN E 1005
REMARK 465 SER E 1006
REMARK 465 THR E 1007
REMARK 465 SER E 1008
REMARK 465 SER E 1009
REMARK 465 LEU E 1010
REMARK 465 LYS E 1011
REMARK 465 ARG E 1012
REMARK 465 GLN E 1013
REMARK 465 ARG E 1014
REMARK 465 LEU E 1015
REMARK 465 GLY E 1016
REMARK 465 SER E 1017
REMARK 465 GLU E 1018
REMARK 465 ARG E 1019
REMARK 465 ALA E 1020
REMARK 465 ALA E 1021
REMARK 465 SER E 1022
REMARK 465 HIS E 1023
REMARK 465 VAL E 1024
REMARK 465 ALA E 1025
REMARK 465 GLN E 1026
REMARK 465 ALA E 1027
REMARK 465 ASN E 1028
REMARK 465 LEU E 1029
REMARK 465 LYS E 1030
REMARK 465 LEU E 1031
REMARK 465 LEU E 1032
REMARK 465 ASP E 1033
REMARK 465 VAL E 1034
REMARK 465 SER E 1035
REMARK 465 LYS E 1036
REMARK 465 ILE E 1037
REMARK 465 PHE E 1038
REMARK 465 PRO E 1039
REMARK 465 ILE E 1040
REMARK 465 ALA E 1041
REMARK 465 GLU E 1042
REMARK 465 ILE E 1043
REMARK 465 ALA E 1044
REMARK 465 GLU E 1045
REMARK 465 GLU E 1046
REMARK 465 SER E 1047
REMARK 465 SER E 1048
REMARK 465 PRO E 1049
REMARK 465 GLU E 1050
REMARK 465 VAL E 1051
REMARK 465 VAL E 1052
REMARK 465 PRO E 1053
REMARK 465 VAL E 1054
REMARK 465 GLU E 1055
REMARK 465 LEU E 1056
REMARK 465 LEU E 1057
REMARK 465 CYS E 1058
REMARK 465 VAL E 1059
REMARK 465 PRO E 1060
REMARK 465 SER E 1061
REMARK 465 PRO E 1062
REMARK 465 ALA E 1063
REMARK 465 SER E 1064
REMARK 465 GLN E 1065
REMARK 465 GLY E 1066
REMARK 465 ASP E 1067
REMARK 465 LEU E 1068
REMARK 465 HIS E 1069
REMARK 465 THR E 1070
REMARK 465 LYS E 1071
REMARK 465 PRO E 1072
REMARK 465 LEU E 1073
REMARK 465 GLY E 1074
REMARK 465 THR E 1075
REMARK 465 ASP E 1076
REMARK 465 ASP E 1077
REMARK 465 ASP E 1078
REMARK 465 SER E 1213
REMARK 465 PRO E 1214
REMARK 465 LEU E 1215
REMARK 465 GLY E 1216
REMARK 465 VAL E 1217
REMARK 465 LEU E 1218
REMARK 465 LEU E 1219
REMARK 465 LYS E 1220
REMARK 465 MET E 1221
REMARK 465 ILE E 1222
REMARK 465 HIS E 1223
REMARK 465 ASN E 1224
REMARK 465 ALA E 1225
REMARK 465 LEU E 1226
REMARK 465 ARG E 1227
REMARK 465 PHE E 1228
REMARK 465 ILE E 1229
REMARK 465 PRO E 1230
REMARK 465 VAL E 1231
REMARK 465 THR E 1232
REMARK 465 SER E 1233
REMARK 465 VAL E 1234
REMARK 465 VAL E 1235
REMARK 465 LEU E 1236
REMARK 465 LEU E 1237
REMARK 465 TYR E 1238
REMARK 465 HIS E 1239
REMARK 465 ARG E 1240
REMARK 465 VAL E 1241
REMARK 465 HIS E 1242
REMARK 465 PRO E 1243
REMARK 465 GLU E 1244
REMARK 465 GLU E 1245
REMARK 465 VAL E 1246
REMARK 465 THR E 1247
REMARK 465 PHE E 1248
REMARK 465 HIS E 1249
REMARK 465 LEU E 1250
REMARK 465 TYR E 1251
REMARK 465 LEU E 1252
REMARK 465 ILE E 1253
REMARK 465 PRO E 1254
REMARK 465 SER E 1255
REMARK 465 ASP E 1256
REMARK 465 CYS E 1257
REMARK 465 SER E 1258
REMARK 465 ILE E 1259
REMARK 465 ARG E 1260
REMARK 465 LYS E 1261
REMARK 465 ALA E 1262
REMARK 465 ILE E 1263
REMARK 465 ASP E 1264
REMARK 465 ASP E 1265
REMARK 465 LEU E 1266
REMARK 465 GLU E 1267
REMARK 465 MET E 1268
REMARK 465 LYS E 1269
REMARK 465 PHE E 1270
REMARK 465 GLN E 1271
REMARK 465 PHE E 1272
REMARK 465 VAL E 1273
REMARK 465 ARG E 1274
REMARK 465 ILE E 1275
REMARK 465 HIS E 1276
REMARK 465 LYS E 1277
REMARK 465 PRO E 1278
REMARK 465 PRO E 1279
REMARK 465 PRO E 1280
REMARK 465 LEU E 1281
REMARK 465 THR E 1282
REMARK 465 PRO E 1283
REMARK 465 LEU E 1284
REMARK 465 TYR E 1285
REMARK 465 MET E 1286
REMARK 465 GLY E 1287
REMARK 465 CYS E 1288
REMARK 465 ARG E 1289
REMARK 465 TYR E 1290
REMARK 465 THR E 1291
REMARK 465 VAL E 1292
REMARK 465 SER E 1293
REMARK 465 GLY E 1294
REMARK 465 SER E 1295
REMARK 465 GLY E 1296
REMARK 465 SER E 1297
REMARK 465 GLY E 1298
REMARK 465 MET E 1299
REMARK 465 LEU E 1300
REMARK 465 GLU E 1301
REMARK 465 ILE E 1302
REMARK 465 LEU E 1303
REMARK 465 PRO E 1304
REMARK 465 LYS E 1305
REMARK 465 GLU E 1306
REMARK 465 LEU E 1307
REMARK 465 GLU E 1308
REMARK 465 LEU E 1309
REMARK 465 CYS E 1310
REMARK 465 TYR E 1311
REMARK 465 ARG E 1312
REMARK 465 SER E 1313
REMARK 465 PRO E 1314
REMARK 465 GLY E 1315
REMARK 465 GLU E 1316
REMARK 465 ASP E 1317
REMARK 465 GLN E 1318
REMARK 465 LEU E 1319
REMARK 465 PHE E 1320
REMARK 465 SER E 1321
REMARK 465 GLU E 1322
REMARK 465 PHE E 1323
REMARK 465 TYR E 1324
REMARK 465 VAL E 1325
REMARK 465 GLY E 1326
REMARK 465 HIS E 1327
REMARK 465 LEU E 1328
REMARK 465 GLY E 1329
REMARK 465 SER E 1330
REMARK 465 GLY E 1331
REMARK 465 ILE E 1332
REMARK 465 ARG E 1333
REMARK 465 LEU E 1334
REMARK 465 GLN E 1335
REMARK 465 VAL E 1336
REMARK 465 LYS E 1337
REMARK 465 ASP E 1338
REMARK 465 LYS E 1339
REMARK 465 LYS E 1340
REMARK 465 ASP E 1341
REMARK 465 GLU E 1342
REMARK 465 THR E 1343
REMARK 465 LEU E 1344
REMARK 465 VAL E 1345
REMARK 465 TRP E 1346
REMARK 465 GLU E 1347
REMARK 465 ALA E 1348
REMARK 465 LEU E 1349
REMARK 465 VAL E 1350
REMARK 465 LYS E 1351
REMARK 465 PRO E 1352
REMARK 465 GLY E 1353
REMARK 465 ASP E 1354
REMARK 465 LEU E 1355
REMARK 465 MET E 1356
REMARK 465 PRO E 1357
REMARK 465 ALA E 1358
REMARK 465 THR E 1359
REMARK 465 THR E 1360
REMARK 465 LEU E 1361
REMARK 465 ILE E 1362
REMARK 465 PRO E 1363
REMARK 465 PRO E 1364
REMARK 465 ALA E 1365
REMARK 465 ARG E 1366
REMARK 465 ILE E 1367
REMARK 465 ALA E 1368
REMARK 465 VAL E 1369
REMARK 465 PRO E 1370
REMARK 465 SER E 1371
REMARK 465 PRO E 1372
REMARK 465 LEU E 1373
REMARK 465 ASP E 1374
REMARK 465 ALA E 1375
REMARK 465 PRO E 1376
REMARK 465 GLN E 1377
REMARK 465 LEU E 1378
REMARK 465 LEU E 1379
REMARK 465 HIS E 1380
REMARK 465 PHE E 1381
REMARK 465 VAL E 1382
REMARK 465 ASP E 1383
REMARK 465 GLN E 1384
REMARK 465 TYR E 1385
REMARK 465 ARG E 1386
REMARK 465 GLU E 1387
REMARK 465 GLN E 1388
REMARK 465 LEU E 1389
REMARK 465 ILE E 1390
REMARK 465 ALA E 1391
REMARK 465 ARG E 1392
REMARK 465 VAL E 1393
REMARK 465 THR E 1394
REMARK 465 SER E 1395
REMARK 465 VAL E 1396
REMARK 465 GLU E 1397
REMARK 465 VAL E 1398
REMARK 465 VAL E 1399
REMARK 465 LEU E 1400
REMARK 465 ASP E 1401
REMARK 465 LYS E 1402
REMARK 465 LEU E 1403
REMARK 465 HIS E 1404
REMARK 465 GLY E 1405
REMARK 465 GLN E 1406
REMARK 465 VAL E 1407
REMARK 465 LEU E 1408
REMARK 465 SER E 1409
REMARK 465 GLN E 1410
REMARK 465 GLU E 1411
REMARK 465 GLN E 1412
REMARK 465 TYR E 1413
REMARK 465 GLU E 1414
REMARK 465 ARG E 1415
REMARK 465 VAL E 1416
REMARK 465 LEU E 1417
REMARK 465 ALA E 1418
REMARK 465 GLU E 1419
REMARK 465 ASN E 1420
REMARK 465 THR E 1421
REMARK 465 ARG E 1422
REMARK 465 PRO E 1423
REMARK 465 SER E 1424
REMARK 465 GLN E 1425
REMARK 465 MET E 1426
REMARK 465 ARG E 1427
REMARK 465 LYS E 1428
REMARK 465 LEU E 1429
REMARK 465 PHE E 1430
REMARK 465 SER E 1431
REMARK 465 LEU E 1432
REMARK 465 SER E 1433
REMARK 465 GLN E 1434
REMARK 465 SER E 1435
REMARK 465 TRP E 1436
REMARK 465 ASP E 1437
REMARK 465 ARG E 1438
REMARK 465 LYS E 1439
REMARK 465 CYS E 1440
REMARK 465 LYS E 1441
REMARK 465 ASP E 1442
REMARK 465 GLY E 1443
REMARK 465 LEU E 1444
REMARK 465 TYR E 1445
REMARK 465 GLN E 1446
REMARK 465 ALA E 1447
REMARK 465 LEU E 1448
REMARK 465 LYS E 1449
REMARK 465 GLU E 1450
REMARK 465 THR E 1451
REMARK 465 HIS E 1452
REMARK 465 PRO E 1453
REMARK 465 HIS E 1454
REMARK 465 LEU E 1455
REMARK 465 ILE E 1456
REMARK 465 MET E 1457
REMARK 465 GLU E 1458
REMARK 465 LEU E 1459
REMARK 465 TRP E 1460
REMARK 465 GLU E 1461
REMARK 465 LYS E 1462
REMARK 465 GLY E 1463
REMARK 465 SER E 1464
REMARK 465 LYS E 1465
REMARK 465 LYS E 1466
REMARK 465 GLY E 1467
REMARK 465 LEU E 1468
REMARK 465 LEU E 1469
REMARK 465 PRO E 1470
REMARK 465 LEU E 1471
REMARK 465 SER E 1472
REMARK 465 SER E 1473
REMARK 465 MET F 1
REMARK 465 ALA F 2
REMARK 465 GLY F 3
REMARK 465 GLY F 4
REMARK 465 ALA F 5
REMARK 465 TRP F 6
REMARK 465 GLY F 7
REMARK 465 ARG F 8
REMARK 465 LEU F 9
REMARK 465 ALA F 10
REMARK 465 CYS F 11
REMARK 465 TYR F 12
REMARK 465 LEU F 13
REMARK 465 GLU F 14
REMARK 465 PHE F 15
REMARK 465 LEU F 16
REMARK 465 LYS F 17
REMARK 465 LYS F 18
REMARK 465 GLU F 19
REMARK 465 GLU F 20
REMARK 465 LEU F 21
REMARK 465 LYS F 22
REMARK 465 GLU F 23
REMARK 465 PHE F 24
REMARK 465 GLN F 25
REMARK 465 LEU F 26
REMARK 465 LEU F 27
REMARK 465 LEU F 28
REMARK 465 ALA F 29
REMARK 465 ASN F 30
REMARK 465 LYS F 31
REMARK 465 ALA F 32
REMARK 465 HIS F 33
REMARK 465 SER F 34
REMARK 465 ARG F 35
REMARK 465 SER F 36
REMARK 465 SER F 37
REMARK 465 SER F 38
REMARK 465 GLY F 39
REMARK 465 GLU F 40
REMARK 465 THR F 41
REMARK 465 PRO F 42
REMARK 465 ALA F 43
REMARK 465 GLN F 44
REMARK 465 PRO F 45
REMARK 465 GLU F 46
REMARK 465 LYS F 47
REMARK 465 THR F 48
REMARK 465 SER F 49
REMARK 465 GLY F 50
REMARK 465 MET F 51
REMARK 465 GLU F 52
REMARK 465 VAL F 53
REMARK 465 ALA F 54
REMARK 465 SER F 55
REMARK 465 TYR F 56
REMARK 465 LEU F 57
REMARK 465 VAL F 58
REMARK 465 ALA F 59
REMARK 465 GLN F 60
REMARK 465 TYR F 61
REMARK 465 GLY F 62
REMARK 465 GLU F 63
REMARK 465 GLN F 64
REMARK 465 ARG F 65
REMARK 465 ALA F 66
REMARK 465 TRP F 67
REMARK 465 ASP F 68
REMARK 465 LEU F 69
REMARK 465 ALA F 70
REMARK 465 LEU F 71
REMARK 465 HIS F 72
REMARK 465 THR F 73
REMARK 465 TRP F 74
REMARK 465 GLU F 75
REMARK 465 GLN F 76
REMARK 465 MET F 77
REMARK 465 GLY F 78
REMARK 465 LEU F 79
REMARK 465 ARG F 80
REMARK 465 SER F 81
REMARK 465 LEU F 82
REMARK 465 CYS F 83
REMARK 465 ALA F 84
REMARK 465 GLN F 85
REMARK 465 ALA F 86
REMARK 465 GLN F 87
REMARK 465 GLU F 88
REMARK 465 GLY F 89
REMARK 465 ALA F 90
REMARK 465 GLY F 91
REMARK 465 HIS F 92
REMARK 465 SER F 93
REMARK 465 PRO F 94
REMARK 465 SER F 95
REMARK 465 PHE F 96
REMARK 465 PRO F 97
REMARK 465 TYR F 98
REMARK 465 SER F 99
REMARK 465 PRO F 100
REMARK 465 SER F 101
REMARK 465 GLU F 102
REMARK 465 PRO F 103
REMARK 465 HIS F 104
REMARK 465 LEU F 105
REMARK 465 GLY F 106
REMARK 465 SER F 107
REMARK 465 PRO F 108
REMARK 465 SER F 109
REMARK 465 GLN F 110
REMARK 465 PRO F 111
REMARK 465 THR F 112
REMARK 465 SER F 113
REMARK 465 THR F 114
REMARK 465 ALA F 115
REMARK 465 VAL F 116
REMARK 465 LEU F 117
REMARK 465 MET F 118
REMARK 465 PRO F 119
REMARK 465 TRP F 120
REMARK 465 ILE F 121
REMARK 465 HIS F 122
REMARK 465 GLU F 123
REMARK 465 LEU F 124
REMARK 465 PRO F 125
REMARK 465 ALA F 126
REMARK 465 GLY F 127
REMARK 465 CYS F 128
REMARK 465 THR F 129
REMARK 465 GLN F 130
REMARK 465 GLY F 131
REMARK 465 SER F 132
REMARK 465 GLU F 133
REMARK 465 ARG F 134
REMARK 465 ARG F 135
REMARK 465 VAL F 136
REMARK 465 LEU F 137
REMARK 465 ARG F 138
REMARK 465 GLN F 139
REMARK 465 LEU F 140
REMARK 465 PRO F 141
REMARK 465 ASP F 142
REMARK 465 THR F 143
REMARK 465 SER F 144
REMARK 465 GLY F 145
REMARK 465 ARG F 146
REMARK 465 ARG F 147
REMARK 465 TRP F 148
REMARK 465 ARG F 149
REMARK 465 GLU F 150
REMARK 465 ILE F 151
REMARK 465 SER F 152
REMARK 465 ALA F 153
REMARK 465 SER F 154
REMARK 465 LEU F 155
REMARK 465 LEU F 156
REMARK 465 TYR F 157
REMARK 465 GLN F 158
REMARK 465 ALA F 159
REMARK 465 LEU F 160
REMARK 465 PRO F 161
REMARK 465 SER F 162
REMARK 465 SER F 163
REMARK 465 PRO F 164
REMARK 465 ASP F 165
REMARK 465 HIS F 166
REMARK 465 GLU F 167
REMARK 465 SER F 168
REMARK 465 PRO F 169
REMARK 465 SER F 170
REMARK 465 GLN F 171
REMARK 465 GLU F 172
REMARK 465 SER F 173
REMARK 465 PRO F 174
REMARK 465 ASN F 175
REMARK 465 ALA F 176
REMARK 465 PRO F 177
REMARK 465 THR F 178
REMARK 465 SER F 179
REMARK 465 THR F 180
REMARK 465 ALA F 181
REMARK 465 VAL F 182
REMARK 465 LEU F 183
REMARK 465 GLY F 184
REMARK 465 SER F 185
REMARK 465 TRP F 186
REMARK 465 GLY F 187
REMARK 465 SER F 188
REMARK 465 PRO F 189
REMARK 465 PRO F 190
REMARK 465 GLN F 191
REMARK 465 PRO F 192
REMARK 465 SER F 193
REMARK 465 LEU F 194
REMARK 465 ALA F 195
REMARK 465 PRO F 196
REMARK 465 ARG F 197
REMARK 465 GLU F 198
REMARK 465 GLN F 199
REMARK 465 GLU F 200
REMARK 465 ALA F 201
REMARK 465 PRO F 202
REMARK 465 GLY F 203
REMARK 465 THR F 204
REMARK 465 GLN F 205
REMARK 465 TRP F 206
REMARK 465 PRO F 207
REMARK 465 LEU F 208
REMARK 465 ASP F 209
REMARK 465 GLU F 210
REMARK 465 THR F 211
REMARK 465 SER F 212
REMARK 465 GLY F 213
REMARK 465 ILE F 214
REMARK 465 TYR F 215
REMARK 465 TYR F 216
REMARK 465 THR F 217
REMARK 465 GLU F 218
REMARK 465 ILE F 219
REMARK 465 ARG F 220
REMARK 465 GLU F 221
REMARK 465 ARG F 222
REMARK 465 GLU F 223
REMARK 465 ARG F 224
REMARK 465 GLU F 225
REMARK 465 LYS F 226
REMARK 465 SER F 227
REMARK 465 GLU F 228
REMARK 465 LYS F 229
REMARK 465 GLY F 230
REMARK 465 ARG F 231
REMARK 465 PRO F 232
REMARK 465 PRO F 233
REMARK 465 TRP F 234
REMARK 465 ALA F 235
REMARK 465 ALA F 236
REMARK 465 VAL F 237
REMARK 465 VAL F 238
REMARK 465 GLY F 239
REMARK 465 THR F 240
REMARK 465 PRO F 241
REMARK 465 PRO F 242
REMARK 465 GLN F 243
REMARK 465 ALA F 244
REMARK 465 HIS F 245
REMARK 465 THR F 246
REMARK 465 SER F 247
REMARK 465 LEU F 248
REMARK 465 GLN F 249
REMARK 465 PRO F 250
REMARK 465 HIS F 251
REMARK 465 HIS F 252
REMARK 465 HIS F 253
REMARK 465 PRO F 254
REMARK 465 TRP F 255
REMARK 465 GLU F 256
REMARK 465 PRO F 257
REMARK 465 SER F 258
REMARK 465 VAL F 259
REMARK 465 ARG F 260
REMARK 465 GLU F 261
REMARK 465 SER F 262
REMARK 465 LEU F 263
REMARK 465 CYS F 264
REMARK 465 SER F 265
REMARK 465 THR F 266
REMARK 465 TRP F 267
REMARK 465 PRO F 268
REMARK 465 TRP F 269
REMARK 465 LYS F 270
REMARK 465 ASN F 271
REMARK 465 GLU F 272
REMARK 465 ASP F 273
REMARK 465 PHE F 274
REMARK 465 ASN F 275
REMARK 465 GLN F 276
REMARK 465 LYS F 277
REMARK 465 PHE F 278
REMARK 465 THR F 279
REMARK 465 GLN F 280
REMARK 465 LEU F 281
REMARK 465 LEU F 282
REMARK 465 LEU F 283
REMARK 465 LEU F 284
REMARK 465 GLN F 285
REMARK 465 ARG F 286
REMARK 465 PRO F 287
REMARK 465 HIS F 288
REMARK 465 PRO F 289
REMARK 465 ARG F 290
REMARK 465 SER F 291
REMARK 465 GLN F 292
REMARK 465 ASP F 293
REMARK 465 PRO F 294
REMARK 465 LEU F 295
REMARK 465 VAL F 296
REMARK 465 LYS F 297
REMARK 465 ARG F 298
REMARK 465 SER F 299
REMARK 465 TRP F 300
REMARK 465 PRO F 301
REMARK 465 ASP F 302
REMARK 465 TYR F 303
REMARK 465 VAL F 304
REMARK 465 GLU F 305
REMARK 465 GLU F 306
REMARK 465 ASN F 307
REMARK 465 ARG F 308
REMARK 465 GLY F 309
REMARK 465 HIS F 310
REMARK 465 LEU F 311
REMARK 465 ILE F 312
REMARK 465 GLU F 313
REMARK 465 ILE F 314
REMARK 465 ARG F 315
REMARK 465 ASP F 316
REMARK 465 LEU F 317
REMARK 465 PHE F 318
REMARK 465 GLY F 319
REMARK 465 PRO F 320
REMARK 465 GLY F 321
REMARK 465 LEU F 322
REMARK 465 ASP F 323
REMARK 465 THR F 324
REMARK 465 GLN F 325
REMARK 465 GLU F 326
REMARK 465 PRO F 327
REMARK 465 ARG F 328
REMARK 465 ILE F 329
REMARK 465 VAL F 330
REMARK 465 ILE F 331
REMARK 465 LEU F 332
REMARK 465 GLN F 333
REMARK 465 GLY F 334
REMARK 465 ALA F 335
REMARK 465 ALA F 336
REMARK 465 GLY F 337
REMARK 465 ILE F 338
REMARK 465 GLY F 339
REMARK 465 LYS F 340
REMARK 465 SER F 341
REMARK 465 THR F 342
REMARK 465 LEU F 343
REMARK 465 ALA F 344
REMARK 465 ARG F 345
REMARK 465 GLN F 346
REMARK 465 VAL F 347
REMARK 465 LYS F 348
REMARK 465 GLU F 349
REMARK 465 ALA F 350
REMARK 465 TRP F 351
REMARK 465 GLY F 352
REMARK 465 ARG F 353
REMARK 465 GLY F 354
REMARK 465 GLN F 355
REMARK 465 LEU F 356
REMARK 465 TYR F 357
REMARK 465 GLY F 358
REMARK 465 ASP F 359
REMARK 465 ARG F 360
REMARK 465 PHE F 361
REMARK 465 GLN F 362
REMARK 465 HIS F 363
REMARK 465 VAL F 364
REMARK 465 PHE F 365
REMARK 465 TYR F 366
REMARK 465 PHE F 367
REMARK 465 SER F 368
REMARK 465 CYS F 369
REMARK 465 ARG F 370
REMARK 465 GLU F 371
REMARK 465 LEU F 372
REMARK 465 ALA F 373
REMARK 465 GLN F 374
REMARK 465 SER F 375
REMARK 465 LYS F 376
REMARK 465 VAL F 377
REMARK 465 VAL F 378
REMARK 465 SER F 379
REMARK 465 LEU F 380
REMARK 465 ALA F 381
REMARK 465 GLU F 382
REMARK 465 LEU F 383
REMARK 465 ILE F 384
REMARK 465 GLY F 385
REMARK 465 LYS F 386
REMARK 465 ASP F 387
REMARK 465 GLY F 388
REMARK 465 THR F 389
REMARK 465 ALA F 390
REMARK 465 THR F 391
REMARK 465 PRO F 392
REMARK 465 ALA F 393
REMARK 465 PRO F 394
REMARK 465 ILE F 395
REMARK 465 ARG F 396
REMARK 465 GLN F 397
REMARK 465 ILE F 398
REMARK 465 LEU F 399
REMARK 465 SER F 400
REMARK 465 ARG F 401
REMARK 465 PRO F 402
REMARK 465 GLU F 403
REMARK 465 ARG F 404
REMARK 465 LEU F 405
REMARK 465 LEU F 406
REMARK 465 PHE F 407
REMARK 465 ILE F 408
REMARK 465 LEU F 409
REMARK 465 ASP F 410
REMARK 465 GLY F 411
REMARK 465 VAL F 412
REMARK 465 ASP F 413
REMARK 465 GLU F 414
REMARK 465 PRO F 415
REMARK 465 GLY F 416
REMARK 465 TRP F 417
REMARK 465 VAL F 418
REMARK 465 LEU F 419
REMARK 465 GLN F 420
REMARK 465 GLU F 421
REMARK 465 PRO F 422
REMARK 465 SER F 423
REMARK 465 SER F 424
REMARK 465 GLU F 425
REMARK 465 LEU F 426
REMARK 465 CYS F 427
REMARK 465 LEU F 428
REMARK 465 HIS F 429
REMARK 465 TRP F 430
REMARK 465 SER F 431
REMARK 465 GLN F 432
REMARK 465 PRO F 433
REMARK 465 GLN F 434
REMARK 465 PRO F 435
REMARK 465 ALA F 436
REMARK 465 ASP F 437
REMARK 465 ALA F 438
REMARK 465 LEU F 439
REMARK 465 LEU F 440
REMARK 465 GLY F 441
REMARK 465 SER F 442
REMARK 465 LEU F 443
REMARK 465 LEU F 444
REMARK 465 GLY F 445
REMARK 465 LYS F 446
REMARK 465 THR F 447
REMARK 465 ILE F 448
REMARK 465 LEU F 449
REMARK 465 PRO F 450
REMARK 465 GLU F 451
REMARK 465 ALA F 452
REMARK 465 SER F 453
REMARK 465 PHE F 454
REMARK 465 LEU F 455
REMARK 465 ILE F 456
REMARK 465 THR F 457
REMARK 465 ALA F 458
REMARK 465 ARG F 459
REMARK 465 THR F 460
REMARK 465 THR F 461
REMARK 465 ALA F 462
REMARK 465 LEU F 463
REMARK 465 GLN F 464
REMARK 465 ASN F 465
REMARK 465 LEU F 466
REMARK 465 ILE F 467
REMARK 465 PRO F 468
REMARK 465 SER F 469
REMARK 465 LEU F 470
REMARK 465 GLU F 471
REMARK 465 GLN F 472
REMARK 465 ALA F 473
REMARK 465 ARG F 474
REMARK 465 TRP F 475
REMARK 465 VAL F 476
REMARK 465 GLU F 477
REMARK 465 VAL F 478
REMARK 465 LEU F 479
REMARK 465 GLY F 480
REMARK 465 PHE F 481
REMARK 465 SER F 482
REMARK 465 GLU F 483
REMARK 465 SER F 484
REMARK 465 SER F 485
REMARK 465 ARG F 486
REMARK 465 LYS F 487
REMARK 465 GLU F 488
REMARK 465 TYR F 489
REMARK 465 PHE F 490
REMARK 465 TYR F 491
REMARK 465 ARG F 492
REMARK 465 TYR F 493
REMARK 465 PHE F 494
REMARK 465 THR F 495
REMARK 465 ASP F 496
REMARK 465 GLU F 497
REMARK 465 ARG F 498
REMARK 465 GLN F 499
REMARK 465 ALA F 500
REMARK 465 ILE F 501
REMARK 465 ARG F 502
REMARK 465 ALA F 503
REMARK 465 PHE F 504
REMARK 465 ARG F 505
REMARK 465 LEU F 506
REMARK 465 VAL F 507
REMARK 465 LYS F 508
REMARK 465 SER F 509
REMARK 465 ASN F 510
REMARK 465 LYS F 511
REMARK 465 GLU F 512
REMARK 465 LEU F 513
REMARK 465 TRP F 514
REMARK 465 ALA F 515
REMARK 465 LEU F 516
REMARK 465 CYS F 517
REMARK 465 LEU F 518
REMARK 465 VAL F 519
REMARK 465 PRO F 520
REMARK 465 TRP F 521
REMARK 465 VAL F 522
REMARK 465 SER F 523
REMARK 465 TRP F 524
REMARK 465 LEU F 525
REMARK 465 ALA F 526
REMARK 465 CYS F 527
REMARK 465 THR F 528
REMARK 465 CYS F 529
REMARK 465 LEU F 530
REMARK 465 MET F 531
REMARK 465 GLN F 532
REMARK 465 GLN F 533
REMARK 465 MET F 534
REMARK 465 LYS F 535
REMARK 465 ARG F 536
REMARK 465 LYS F 537
REMARK 465 GLU F 538
REMARK 465 LYS F 539
REMARK 465 LEU F 540
REMARK 465 THR F 541
REMARK 465 LEU F 542
REMARK 465 THR F 543
REMARK 465 SER F 544
REMARK 465 LYS F 545
REMARK 465 THR F 546
REMARK 465 THR F 547
REMARK 465 THR F 548
REMARK 465 THR F 549
REMARK 465 LEU F 550
REMARK 465 CYS F 551
REMARK 465 LEU F 552
REMARK 465 HIS F 553
REMARK 465 TYR F 554
REMARK 465 LEU F 555
REMARK 465 ALA F 556
REMARK 465 GLN F 557
REMARK 465 ALA F 558
REMARK 465 LEU F 559
REMARK 465 GLN F 560
REMARK 465 ALA F 561
REMARK 465 GLN F 562
REMARK 465 PRO F 563
REMARK 465 LEU F 564
REMARK 465 GLY F 565
REMARK 465 PRO F 566
REMARK 465 GLN F 567
REMARK 465 LEU F 568
REMARK 465 ARG F 569
REMARK 465 ASP F 570
REMARK 465 LEU F 571
REMARK 465 CYS F 572
REMARK 465 SER F 573
REMARK 465 LEU F 574
REMARK 465 ALA F 575
REMARK 465 ALA F 576
REMARK 465 GLU F 577
REMARK 465 GLY F 578
REMARK 465 ILE F 579
REMARK 465 TRP F 580
REMARK 465 GLN F 581
REMARK 465 LYS F 582
REMARK 465 LYS F 583
REMARK 465 THR F 584
REMARK 465 LEU F 585
REMARK 465 PHE F 586
REMARK 465 SER F 587
REMARK 465 PRO F 588
REMARK 465 ASP F 589
REMARK 465 ASP F 590
REMARK 465 LEU F 591
REMARK 465 ARG F 592
REMARK 465 LYS F 593
REMARK 465 HIS F 594
REMARK 465 GLY F 595
REMARK 465 LEU F 596
REMARK 465 ASP F 597
REMARK 465 GLY F 598
REMARK 465 ALA F 599
REMARK 465 ILE F 600
REMARK 465 ILE F 601
REMARK 465 SER F 602
REMARK 465 THR F 603
REMARK 465 PHE F 604
REMARK 465 LEU F 605
REMARK 465 LYS F 606
REMARK 465 MET F 607
REMARK 465 GLY F 608
REMARK 465 ILE F 609
REMARK 465 LEU F 610
REMARK 465 GLN F 611
REMARK 465 GLU F 612
REMARK 465 HIS F 613
REMARK 465 PRO F 614
REMARK 465 ILE F 615
REMARK 465 PRO F 616
REMARK 465 LEU F 617
REMARK 465 SER F 618
REMARK 465 TYR F 619
REMARK 465 SER F 620
REMARK 465 PHE F 621
REMARK 465 ILE F 622
REMARK 465 HIS F 623
REMARK 465 LEU F 624
REMARK 465 CYS F 625
REMARK 465 PHE F 626
REMARK 465 GLN F 627
REMARK 465 GLU F 628
REMARK 465 PHE F 629
REMARK 465 PHE F 630
REMARK 465 ALA F 631
REMARK 465 ALA F 632
REMARK 465 MET F 633
REMARK 465 SER F 634
REMARK 465 TYR F 635
REMARK 465 VAL F 636
REMARK 465 LEU F 637
REMARK 465 GLU F 638
REMARK 465 ASP F 639
REMARK 465 GLU F 640
REMARK 465 LYS F 641
REMARK 465 GLY F 642
REMARK 465 ARG F 643
REMARK 465 GLY F 644
REMARK 465 LYS F 645
REMARK 465 HIS F 646
REMARK 465 SER F 647
REMARK 465 ASN F 648
REMARK 465 CYS F 649
REMARK 465 ILE F 650
REMARK 465 ILE F 651
REMARK 465 ASP F 652
REMARK 465 LEU F 653
REMARK 465 GLU F 654
REMARK 465 LYS F 655
REMARK 465 THR F 656
REMARK 465 LEU F 657
REMARK 465 GLU F 658
REMARK 465 ALA F 659
REMARK 465 TYR F 660
REMARK 465 GLY F 661
REMARK 465 ILE F 662
REMARK 465 HIS F 663
REMARK 465 GLY F 664
REMARK 465 LEU F 665
REMARK 465 PHE F 666
REMARK 465 GLY F 667
REMARK 465 ALA F 668
REMARK 465 SER F 669
REMARK 465 THR F 670
REMARK 465 THR F 671
REMARK 465 ARG F 672
REMARK 465 PHE F 673
REMARK 465 LEU F 674
REMARK 465 LEU F 675
REMARK 465 GLY F 676
REMARK 465 LEU F 677
REMARK 465 LEU F 678
REMARK 465 SER F 679
REMARK 465 ASP F 680
REMARK 465 GLU F 681
REMARK 465 GLY F 682
REMARK 465 GLU F 683
REMARK 465 ARG F 684
REMARK 465 GLU F 685
REMARK 465 MET F 686
REMARK 465 GLU F 687
REMARK 465 ASN F 688
REMARK 465 ILE F 689
REMARK 465 PHE F 690
REMARK 465 HIS F 691
REMARK 465 CYS F 692
REMARK 465 ARG F 693
REMARK 465 LEU F 694
REMARK 465 SER F 695
REMARK 465 GLN F 696
REMARK 465 GLY F 697
REMARK 465 ARG F 698
REMARK 465 ASN F 699
REMARK 465 LEU F 700
REMARK 465 MET F 701
REMARK 465 GLN F 702
REMARK 465 TRP F 703
REMARK 465 VAL F 704
REMARK 465 PRO F 705
REMARK 465 SER F 706
REMARK 465 LEU F 707
REMARK 465 GLN F 708
REMARK 465 LEU F 709
REMARK 465 LEU F 710
REMARK 465 LEU F 711
REMARK 465 GLN F 712
REMARK 465 PRO F 713
REMARK 465 HIS F 714
REMARK 465 SER F 715
REMARK 465 LEU F 716
REMARK 465 GLU F 717
REMARK 465 SER F 718
REMARK 465 LEU F 719
REMARK 465 HIS F 720
REMARK 465 CYS F 721
REMARK 465 LEU F 722
REMARK 465 TYR F 723
REMARK 465 GLU F 724
REMARK 465 THR F 725
REMARK 465 ARG F 726
REMARK 465 ASN F 727
REMARK 465 LYS F 728
REMARK 465 THR F 729
REMARK 465 PHE F 730
REMARK 465 LEU F 731
REMARK 465 THR F 732
REMARK 465 GLN F 733
REMARK 465 VAL F 734
REMARK 465 MET F 735
REMARK 465 ALA F 736
REMARK 465 HIS F 737
REMARK 465 PHE F 738
REMARK 465 GLU F 739
REMARK 465 GLU F 740
REMARK 465 MET F 741
REMARK 465 GLY F 742
REMARK 465 MET F 743
REMARK 465 CYS F 744
REMARK 465 VAL F 745
REMARK 465 GLU F 746
REMARK 465 THR F 747
REMARK 465 ASP F 748
REMARK 465 MET F 749
REMARK 465 GLU F 750
REMARK 465 LEU F 751
REMARK 465 LEU F 752
REMARK 465 VAL F 753
REMARK 465 CYS F 754
REMARK 465 THR F 755
REMARK 465 PHE F 756
REMARK 465 CYS F 757
REMARK 465 ILE F 758
REMARK 465 LYS F 759
REMARK 465 PHE F 760
REMARK 465 SER F 761
REMARK 465 ARG F 762
REMARK 465 HIS F 763
REMARK 465 VAL F 764
REMARK 465 LYS F 765
REMARK 465 LYS F 766
REMARK 465 LEU F 767
REMARK 465 GLN F 768
REMARK 465 LEU F 769
REMARK 465 ILE F 770
REMARK 465 GLU F 771
REMARK 465 GLY F 772
REMARK 465 ARG F 773
REMARK 465 GLN F 774
REMARK 465 HIS F 775
REMARK 465 ARG F 776
REMARK 465 SER F 777
REMARK 465 THR F 778
REMARK 465 TRP F 779
REMARK 465 SER F 780
REMARK 465 PRO F 781
REMARK 465 THR F 782
REMARK 465 MET F 783
REMARK 465 VAL F 784
REMARK 465 VAL F 785
REMARK 465 LEU F 786
REMARK 465 PHE F 787
REMARK 465 ARG F 788
REMARK 465 TRP F 789
REMARK 465 VAL F 790
REMARK 465 PRO F 791
REMARK 465 VAL F 792
REMARK 465 THR F 793
REMARK 465 ASP F 794
REMARK 465 ALA F 795
REMARK 465 TYR F 796
REMARK 465 TRP F 797
REMARK 465 GLN F 798
REMARK 465 ILE F 799
REMARK 465 LEU F 800
REMARK 465 PHE F 801
REMARK 465 SER F 802
REMARK 465 VAL F 803
REMARK 465 LEU F 804
REMARK 465 LYS F 805
REMARK 465 VAL F 806
REMARK 465 THR F 807
REMARK 465 ARG F 808
REMARK 465 ASN F 809
REMARK 465 LEU F 810
REMARK 465 LYS F 811
REMARK 465 GLU F 812
REMARK 465 LEU F 813
REMARK 465 ASP F 814
REMARK 465 LEU F 815
REMARK 465 SER F 816
REMARK 465 GLY F 817
REMARK 465 ASN F 818
REMARK 465 SER F 819
REMARK 465 LEU F 820
REMARK 465 SER F 821
REMARK 465 HIS F 822
REMARK 465 SER F 823
REMARK 465 ALA F 824
REMARK 465 VAL F 825
REMARK 465 LYS F 826
REMARK 465 SER F 827
REMARK 465 LEU F 828
REMARK 465 CYS F 829
REMARK 465 LYS F 830
REMARK 465 THR F 831
REMARK 465 LEU F 832
REMARK 465 ARG F 833
REMARK 465 ARG F 834
REMARK 465 PRO F 835
REMARK 465 ARG F 836
REMARK 465 CYS F 837
REMARK 465 LEU F 838
REMARK 465 LEU F 839
REMARK 465 GLU F 840
REMARK 465 THR F 841
REMARK 465 LEU F 842
REMARK 465 ARG F 843
REMARK 465 LEU F 844
REMARK 465 ALA F 845
REMARK 465 GLY F 846
REMARK 465 CYS F 847
REMARK 465 GLY F 848
REMARK 465 LEU F 849
REMARK 465 THR F 850
REMARK 465 ALA F 851
REMARK 465 GLU F 852
REMARK 465 ASP F 853
REMARK 465 CYS F 854
REMARK 465 LYS F 855
REMARK 465 ASP F 856
REMARK 465 LEU F 857
REMARK 465 ALA F 858
REMARK 465 PHE F 859
REMARK 465 GLY F 860
REMARK 465 LEU F 861
REMARK 465 ARG F 862
REMARK 465 ALA F 863
REMARK 465 ASN F 864
REMARK 465 GLN F 865
REMARK 465 THR F 866
REMARK 465 LEU F 867
REMARK 465 THR F 868
REMARK 465 GLU F 869
REMARK 465 LEU F 870
REMARK 465 ASP F 871
REMARK 465 LEU F 872
REMARK 465 SER F 873
REMARK 465 PHE F 874
REMARK 465 ASN F 875
REMARK 465 VAL F 876
REMARK 465 LEU F 877
REMARK 465 THR F 878
REMARK 465 ASP F 879
REMARK 465 ALA F 880
REMARK 465 GLY F 881
REMARK 465 ALA F 882
REMARK 465 LYS F 883
REMARK 465 HIS F 884
REMARK 465 LEU F 885
REMARK 465 CYS F 886
REMARK 465 GLN F 887
REMARK 465 ARG F 888
REMARK 465 LEU F 889
REMARK 465 ARG F 890
REMARK 465 GLN F 891
REMARK 465 PRO F 892
REMARK 465 SER F 893
REMARK 465 CYS F 894
REMARK 465 LYS F 895
REMARK 465 LEU F 896
REMARK 465 GLN F 897
REMARK 465 ARG F 898
REMARK 465 LEU F 899
REMARK 465 GLN F 900
REMARK 465 LEU F 901
REMARK 465 VAL F 902
REMARK 465 SER F 903
REMARK 465 CYS F 904
REMARK 465 GLY F 905
REMARK 465 LEU F 906
REMARK 465 THR F 907
REMARK 465 SER F 908
REMARK 465 ASP F 909
REMARK 465 CYS F 910
REMARK 465 CYS F 911
REMARK 465 GLN F 912
REMARK 465 ASP F 913
REMARK 465 LEU F 914
REMARK 465 ALA F 915
REMARK 465 SER F 916
REMARK 465 VAL F 917
REMARK 465 LEU F 918
REMARK 465 SER F 919
REMARK 465 ALA F 920
REMARK 465 SER F 921
REMARK 465 PRO F 922
REMARK 465 SER F 923
REMARK 465 LEU F 924
REMARK 465 LYS F 925
REMARK 465 GLU F 926
REMARK 465 LEU F 927
REMARK 465 ASP F 928
REMARK 465 LEU F 929
REMARK 465 GLN F 930
REMARK 465 GLN F 931
REMARK 465 ASN F 932
REMARK 465 ASN F 933
REMARK 465 LEU F 934
REMARK 465 ASP F 935
REMARK 465 ASP F 936
REMARK 465 VAL F 937
REMARK 465 GLY F 938
REMARK 465 VAL F 939
REMARK 465 ARG F 940
REMARK 465 LEU F 941
REMARK 465 LEU F 942
REMARK 465 CYS F 943
REMARK 465 GLU F 944
REMARK 465 GLY F 945
REMARK 465 LEU F 946
REMARK 465 ARG F 947
REMARK 465 HIS F 948
REMARK 465 PRO F 949
REMARK 465 ALA F 950
REMARK 465 CYS F 951
REMARK 465 LYS F 952
REMARK 465 LEU F 953
REMARK 465 ILE F 954
REMARK 465 ARG F 955
REMARK 465 LEU F 956
REMARK 465 GLY F 957
REMARK 465 LEU F 958
REMARK 465 ASP F 959
REMARK 465 GLN F 960
REMARK 465 THR F 961
REMARK 465 THR F 962
REMARK 465 LEU F 963
REMARK 465 SER F 964
REMARK 465 ASP F 965
REMARK 465 GLU F 966
REMARK 465 MET F 967
REMARK 465 ARG F 968
REMARK 465 GLN F 969
REMARK 465 GLU F 970
REMARK 465 LEU F 971
REMARK 465 ARG F 972
REMARK 465 ALA F 973
REMARK 465 LEU F 974
REMARK 465 GLU F 975
REMARK 465 GLN F 976
REMARK 465 GLU F 977
REMARK 465 LYS F 978
REMARK 465 PRO F 979
REMARK 465 GLN F 980
REMARK 465 LEU F 981
REMARK 465 LEU F 982
REMARK 465 ILE F 983
REMARK 465 PHE F 984
REMARK 465 SER F 985
REMARK 465 ARG F 986
REMARK 465 ARG F 987
REMARK 465 LYS F 988
REMARK 465 PRO F 989
REMARK 465 SER F 990
REMARK 465 VAL F 991
REMARK 465 MET F 992
REMARK 465 THR F 993
REMARK 465 PRO F 994
REMARK 465 THR F 995
REMARK 465 GLU F 996
REMARK 465 GLY F 997
REMARK 465 LEU F 998
REMARK 465 ASP F 999
REMARK 465 THR F 1000
REMARK 465 GLY F 1001
REMARK 465 GLU F 1002
REMARK 465 MET F 1003
REMARK 465 SER F 1004
REMARK 465 ASN F 1005
REMARK 465 SER F 1006
REMARK 465 THR F 1007
REMARK 465 SER F 1008
REMARK 465 SER F 1009
REMARK 465 LEU F 1010
REMARK 465 LYS F 1011
REMARK 465 ARG F 1012
REMARK 465 GLN F 1013
REMARK 465 ARG F 1014
REMARK 465 LEU F 1015
REMARK 465 GLY F 1016
REMARK 465 SER F 1017
REMARK 465 GLU F 1018
REMARK 465 ARG F 1019
REMARK 465 ALA F 1020
REMARK 465 ALA F 1021
REMARK 465 SER F 1022
REMARK 465 HIS F 1023
REMARK 465 VAL F 1024
REMARK 465 ALA F 1025
REMARK 465 GLN F 1026
REMARK 465 ALA F 1027
REMARK 465 ASN F 1028
REMARK 465 LEU F 1029
REMARK 465 LYS F 1030
REMARK 465 LEU F 1031
REMARK 465 LEU F 1032
REMARK 465 ASP F 1033
REMARK 465 VAL F 1034
REMARK 465 SER F 1035
REMARK 465 LYS F 1036
REMARK 465 ILE F 1037
REMARK 465 PHE F 1038
REMARK 465 PRO F 1039
REMARK 465 ILE F 1040
REMARK 465 ALA F 1041
REMARK 465 GLU F 1042
REMARK 465 ILE F 1043
REMARK 465 ALA F 1044
REMARK 465 GLU F 1045
REMARK 465 GLU F 1046
REMARK 465 SER F 1047
REMARK 465 SER F 1048
REMARK 465 PRO F 1049
REMARK 465 GLU F 1050
REMARK 465 VAL F 1051
REMARK 465 VAL F 1052
REMARK 465 PRO F 1053
REMARK 465 VAL F 1054
REMARK 465 GLU F 1055
REMARK 465 LEU F 1056
REMARK 465 LEU F 1057
REMARK 465 CYS F 1058
REMARK 465 VAL F 1059
REMARK 465 PRO F 1060
REMARK 465 SER F 1061
REMARK 465 PRO F 1062
REMARK 465 ALA F 1063
REMARK 465 SER F 1064
REMARK 465 GLN F 1065
REMARK 465 GLY F 1066
REMARK 465 ASP F 1067
REMARK 465 LEU F 1068
REMARK 465 HIS F 1069
REMARK 465 THR F 1070
REMARK 465 LYS F 1071
REMARK 465 PRO F 1072
REMARK 465 LEU F 1073
REMARK 465 GLY F 1074
REMARK 465 THR F 1075
REMARK 465 ASP F 1076
REMARK 465 ASP F 1077
REMARK 465 ASP F 1078
REMARK 465 PHE F 1079
REMARK 465 TRP F 1080
REMARK 465 GLY F 1081
REMARK 465 PRO F 1082
REMARK 465 THR F 1083
REMARK 465 GLY F 1084
REMARK 465 PRO F 1085
REMARK 465 VAL F 1086
REMARK 465 ALA F 1087
REMARK 465 THR F 1088
REMARK 465 GLU F 1089
REMARK 465 VAL F 1090
REMARK 465 VAL F 1091
REMARK 465 ASP F 1092
REMARK 465 LYS F 1093
REMARK 465 GLU F 1094
REMARK 465 LYS F 1095
REMARK 465 ASN F 1096
REMARK 465 LEU F 1097
REMARK 465 TYR F 1098
REMARK 465 ARG F 1099
REMARK 465 VAL F 1100
REMARK 465 HIS F 1101
REMARK 465 PHE F 1102
REMARK 465 PRO F 1103
REMARK 465 VAL F 1104
REMARK 465 ALA F 1105
REMARK 465 GLY F 1106
REMARK 465 SER F 1107
REMARK 465 TYR F 1108
REMARK 465 ARG F 1109
REMARK 465 TRP F 1110
REMARK 465 PRO F 1111
REMARK 465 ASN F 1112
REMARK 465 THR F 1113
REMARK 465 GLY F 1114
REMARK 465 LEU F 1115
REMARK 465 CYS F 1116
REMARK 465 PHE F 1117
REMARK 465 VAL F 1118
REMARK 465 MET F 1119
REMARK 465 ARG F 1120
REMARK 465 GLU F 1121
REMARK 465 ALA F 1122
REMARK 465 VAL F 1123
REMARK 465 THR F 1124
REMARK 465 VAL F 1125
REMARK 465 GLU F 1126
REMARK 465 ILE F 1127
REMARK 465 GLU F 1128
REMARK 465 PHE F 1129
REMARK 465 CYS F 1130
REMARK 465 VAL F 1131
REMARK 465 TRP F 1132
REMARK 465 ASP F 1133
REMARK 465 GLN F 1134
REMARK 465 PHE F 1135
REMARK 465 LEU F 1136
REMARK 465 GLY F 1137
REMARK 465 GLU F 1138
REMARK 465 ILE F 1139
REMARK 465 ASN F 1140
REMARK 465 PRO F 1141
REMARK 465 GLN F 1142
REMARK 465 HIS F 1143
REMARK 465 SER F 1144
REMARK 465 TRP F 1145
REMARK 465 MET F 1146
REMARK 465 VAL F 1147
REMARK 465 ALA F 1148
REMARK 465 GLY F 1149
REMARK 465 PRO F 1150
REMARK 465 LEU F 1151
REMARK 465 LEU F 1152
REMARK 465 ASP F 1153
REMARK 465 ILE F 1154
REMARK 465 LYS F 1155
REMARK 465 ALA F 1156
REMARK 465 GLU F 1157
REMARK 465 PRO F 1158
REMARK 465 GLY F 1159
REMARK 465 ALA F 1160
REMARK 465 VAL F 1161
REMARK 465 GLU F 1162
REMARK 465 ALA F 1163
REMARK 465 VAL F 1164
REMARK 465 HIS F 1165
REMARK 465 LEU F 1166
REMARK 465 PRO F 1167
REMARK 465 HIS F 1168
REMARK 465 PHE F 1169
REMARK 465 VAL F 1170
REMARK 465 ALA F 1171
REMARK 465 LEU F 1172
REMARK 465 GLN F 1173
REMARK 465 GLY F 1174
REMARK 465 GLY F 1175
REMARK 465 HIS F 1176
REMARK 465 VAL F 1177
REMARK 465 ASP F 1178
REMARK 465 THR F 1179
REMARK 465 SER F 1180
REMARK 465 LEU F 1181
REMARK 465 PHE F 1182
REMARK 465 GLN F 1183
REMARK 465 MET F 1184
REMARK 465 ALA F 1185
REMARK 465 HIS F 1186
REMARK 465 PHE F 1187
REMARK 465 LYS F 1188
REMARK 465 GLU F 1189
REMARK 465 GLU F 1190
REMARK 465 GLY F 1191
REMARK 465 MET F 1192
REMARK 465 LEU F 1193
REMARK 465 LEU F 1194
REMARK 465 GLU F 1195
REMARK 465 LYS F 1196
REMARK 465 PRO F 1197
REMARK 465 ALA F 1198
REMARK 465 ARG F 1199
REMARK 465 VAL F 1200
REMARK 465 GLU F 1201
REMARK 465 LEU F 1202
REMARK 465 HIS F 1203
REMARK 465 HIS F 1204
REMARK 465 ILE F 1205
REMARK 465 VAL F 1206
REMARK 465 LEU F 1207
REMARK 465 GLU F 1208
REMARK 465 ASN F 1209
REMARK 465 PRO F 1210
REMARK 465 SER F 1211
REMARK 465 PHE F 1212
REMARK 465 LYS F 1351
REMARK 465 PRO F 1352
REMARK 465 GLY F 1353
REMARK 465 ASP F 1354
REMARK 465 LEU F 1355
REMARK 465 MET F 1356
REMARK 465 PRO F 1357
REMARK 465 ALA F 1358
REMARK 465 THR F 1359
REMARK 465 THR F 1360
REMARK 465 LEU F 1361
REMARK 465 ILE F 1362
REMARK 465 PRO F 1363
REMARK 465 PRO F 1364
REMARK 465 ALA F 1365
REMARK 465 ARG F 1366
REMARK 465 ILE F 1367
REMARK 465 ALA F 1368
REMARK 465 VAL F 1369
REMARK 465 PRO F 1370
REMARK 465 SER F 1371
REMARK 465 PRO F 1372
REMARK 465 LEU F 1373
REMARK 465 ASP F 1374
REMARK 465 ALA F 1375
REMARK 465 PRO F 1376
REMARK 465 GLN F 1377
REMARK 465 LEU F 1378
REMARK 465 LEU F 1379
REMARK 465 HIS F 1380
REMARK 465 PHE F 1381
REMARK 465 VAL F 1382
REMARK 465 ASP F 1383
REMARK 465 GLN F 1384
REMARK 465 TYR F 1385
REMARK 465 ARG F 1386
REMARK 465 GLU F 1387
REMARK 465 GLN F 1388
REMARK 465 LEU F 1389
REMARK 465 ILE F 1390
REMARK 465 ALA F 1391
REMARK 465 ARG F 1392
REMARK 465 VAL F 1393
REMARK 465 THR F 1394
REMARK 465 SER F 1395
REMARK 465 VAL F 1396
REMARK 465 GLU F 1397
REMARK 465 VAL F 1398
REMARK 465 VAL F 1399
REMARK 465 LEU F 1400
REMARK 465 ASP F 1401
REMARK 465 LYS F 1402
REMARK 465 LEU F 1403
REMARK 465 HIS F 1404
REMARK 465 GLY F 1405
REMARK 465 GLN F 1406
REMARK 465 VAL F 1407
REMARK 465 LEU F 1408
REMARK 465 SER F 1409
REMARK 465 GLN F 1410
REMARK 465 GLU F 1411
REMARK 465 GLN F 1412
REMARK 465 TYR F 1413
REMARK 465 GLU F 1414
REMARK 465 ARG F 1415
REMARK 465 VAL F 1416
REMARK 465 LEU F 1417
REMARK 465 ALA F 1418
REMARK 465 GLU F 1419
REMARK 465 ASN F 1420
REMARK 465 THR F 1421
REMARK 465 ARG F 1422
REMARK 465 PRO F 1423
REMARK 465 SER F 1424
REMARK 465 GLN F 1425
REMARK 465 MET F 1426
REMARK 465 ARG F 1427
REMARK 465 LYS F 1428
REMARK 465 LEU F 1429
REMARK 465 PHE F 1430
REMARK 465 SER F 1431
REMARK 465 LEU F 1432
REMARK 465 SER F 1433
REMARK 465 GLN F 1434
REMARK 465 SER F 1435
REMARK 465 TRP F 1436
REMARK 465 ASP F 1437
REMARK 465 ARG F 1438
REMARK 465 LYS F 1439
REMARK 465 CYS F 1440
REMARK 465 LYS F 1441
REMARK 465 ASP F 1442
REMARK 465 GLY F 1443
REMARK 465 LEU F 1444
REMARK 465 TYR F 1445
REMARK 465 GLN F 1446
REMARK 465 ALA F 1447
REMARK 465 LEU F 1448
REMARK 465 LYS F 1449
REMARK 465 GLU F 1450
REMARK 465 THR F 1451
REMARK 465 HIS F 1452
REMARK 465 PRO F 1453
REMARK 465 HIS F 1454
REMARK 465 LEU F 1455
REMARK 465 ILE F 1456
REMARK 465 MET F 1457
REMARK 465 GLU F 1458
REMARK 465 LEU F 1459
REMARK 465 TRP F 1460
REMARK 465 GLU F 1461
REMARK 465 LYS F 1462
REMARK 465 GLY F 1463
REMARK 465 SER F 1464
REMARK 465 LYS F 1465
REMARK 465 LYS F 1466
REMARK 465 GLY F 1467
REMARK 465 LEU F 1468
REMARK 465 LEU F 1469
REMARK 465 PRO F 1470
REMARK 465 LEU F 1471
REMARK 465 SER F 1472
REMARK 465 SER F 1473
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470 M RES CSSEQI ATOMS
REMARK 470 ASP A 18 CG OD1 OD2
REMARK 470 GLU A 64 CG CD OE1 OE2
REMARK 470 LEU A 233 CG CD1 CD2
REMARK 470 ASP A 234 CG OD1 OD2
REMARK 470 GLU A 265 CG CD OE1 OE2
REMARK 470 ASP D 18 CG OD1 OD2
REMARK 470 GLU D 64 CG CD OE1 OE2
REMARK 470 LEU D 233 CG CD1 CD2
REMARK 470 ASP D 234 CG OD1 OD2
REMARK 470 GLU D 265 CG CD OE1 OE2
REMARK 470 SER F1213 N
REMARK 470 VAL F1350 CG1 CG2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE
REMARK 500 OG SER A 730 O16 GK2 A 901 1.83
REMARK 500 OG SER D 730 O17 GK2 D 901 1.88
REMARK 500 OG SER A 730 O17 GK2 A 901 2.05
REMARK 500 OG SER D 730 O16 GK2 D 901 2.07
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500 M RES CSSEQI PSI PHI
REMARK 500 ASP A 110 58.67 -93.15
REMARK 500 SER A 156 -126.91 55.80
REMARK 500 ARG A 220 121.83 -171.16
REMARK 500 SER A 230 -157.57 -150.14
REMARK 500 GLU A 268 -65.43 -120.25
REMARK 500 GLU A 282 45.76 -91.16
REMARK 500 ALA A 316 149.51 -170.65
REMARK 500 GLN A 373 62.84 63.10
REMARK 500 GLN A 374 19.77 -143.15
REMARK 500 VAL A 419 -80.57 -102.94
REMARK 500 GLU A 438 70.32 61.13
REMARK 500 CYS A 452 107.52 -59.87
REMARK 500 GLU A 493 41.10 -96.78
REMARK 500 ALA A 498 -41.83 -130.89
REMARK 500 ASP A 618 45.35 75.45
REMARK 500 TYR A 644 -67.02 -127.70
REMARK 500 ASN A 695 15.74 57.99
REMARK 500 GLN A 696 48.05 -151.43
REMARK 500 SER A 730 -115.74 59.29
REMARK 500 ASP A 772 -178.88 76.16
REMARK 500 ASN A 777 67.69 -106.61
REMARK 500 ASN A 810 -79.42 -104.28
REMARK 500 ARG A 839 -76.87 -85.05
REMARK 500 ALA D 21 40.16 -142.35
REMARK 500 ARG D 82 32.11 -90.84
REMARK 500 ALA D 155 -154.97 -101.60
REMARK 500 SER D 156 -74.54 -60.50
REMARK 500 ARG D 220 121.80 -171.01
REMARK 500 PHE D 224 47.04 -141.37
REMARK 500 SER D 230 -157.24 -157.94
REMARK 500 GLU D 268 -63.89 -121.20
REMARK 500 GLU D 282 45.20 -91.25
REMARK 500 ALA D 316 149.02 -170.69
REMARK 500 GLN D 334 121.17 -170.25
REMARK 500 GLN D 373 62.99 63.42
REMARK 500 GLN D 374 19.86 -143.01
REMARK 500 VAL D 419 -80.41 -102.86
REMARK 500 ASP D 425 44.76 -82.33
REMARK 500 GLU D 436 2.59 55.23
REMARK 500 CYS D 452 108.17 -59.85
REMARK 500 GLU D 493 40.71 -96.70
REMARK 500 ALA D 498 -41.00 -131.08
REMARK 500 ASP D 618 44.51 75.32
REMARK 500 TYR D 644 -72.85 -137.98
REMARK 500 ASN D 695 17.11 51.42
REMARK 500 GLN D 696 51.65 -151.63
REMARK 500 SER D 730 -122.46 60.66
REMARK 500 ASN D 777 69.66 -107.08
REMARK 500 ASN D 810 -76.24 -100.51
REMARK 500 ARG D 839 -128.96 -96.53
REMARK 500
REMARK 500 THIS ENTRY HAS 52 RAMACHANDRAN OUTLIERS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: EMD-22075 RELATED DB: EMDB
REMARK 900 IMMUNE SYSTEM
DBREF 6X6C A 1 863 UNP Q86TI2 DPP9_HUMAN 1 863
DBREF 6X6C D 1 863 UNP Q86TI2 DPP9_HUMAN 1 863
DBREF 6X6C E 1 1473 UNP Q9C000 NLRP1_HUMAN 1 1473
DBREF 6X6C F 1 1473 UNP Q9C000 NLRP1_HUMAN 1 1473
SEQADV 6X6C MET A -27 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C SER A -26 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C TYR A -25 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C TYR A -24 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C HIS A -23 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C HIS A -22 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C HIS A -21 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C HIS A -20 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C HIS A -19 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C HIS A -18 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C ASP A -17 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C TYR A -16 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C ASP A -15 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C ILE A -14 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C PRO A -13 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C THR A -12 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C THR A -11 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C GLU A -10 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C ASN A -9 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C LEU A -8 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C TYR A -7 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C PHE A -6 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C GLN A -5 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C GLY A -4 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C ALA A -3 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C MET A -2 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C GLY A -1 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C SER A 0 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C MET D -27 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C SER D -26 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C TYR D -25 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C TYR D -24 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C HIS D -23 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C HIS D -22 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C HIS D -21 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C HIS D -20 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C HIS D -19 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C HIS D -18 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C ASP D -17 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C TYR D -16 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C ASP D -15 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C ILE D -14 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C PRO D -13 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C THR D -12 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C THR D -11 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C GLU D -10 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C ASN D -9 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C LEU D -8 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C TYR D -7 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C PHE D -6 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C GLN D -5 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C GLY D -4 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C ALA D -3 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C MET D -2 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C GLY D -1 UNP Q86TI2 EXPRESSION TAG
SEQADV 6X6C SER D 0 UNP Q86TI2 EXPRESSION TAG
SEQRES 1 A 891 MET SER TYR TYR HIS HIS HIS HIS HIS HIS ASP TYR ASP
SEQRES 2 A 891 ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY ALA MET
SEQRES 3 A 891 GLY SER MET ALA THR THR GLY THR PRO THR ALA ASP ARG
SEQRES 4 A 891 GLY ASP ALA ALA ALA THR ASP ASP PRO ALA ALA ARG PHE
SEQRES 5 A 891 GLN VAL GLN LYS HIS SER TRP ASP GLY LEU ARG SER ILE
SEQRES 6 A 891 ILE HIS GLY SER ARG LYS TYR SER GLY LEU ILE VAL ASN
SEQRES 7 A 891 LYS ALA PRO HIS ASP PHE GLN PHE VAL GLN LYS THR ASP
SEQRES 8 A 891 GLU SER GLY PRO HIS SER HIS ARG LEU TYR TYR LEU GLY
SEQRES 9 A 891 MET PRO TYR GLY SER ARG GLU ASN SER LEU LEU TYR SER
SEQRES 10 A 891 GLU ILE PRO LYS LYS VAL ARG LYS GLU ALA LEU LEU LEU
SEQRES 11 A 891 LEU SER TRP LYS GLN MET LEU ASP HIS PHE GLN ALA THR
SEQRES 12 A 891 PRO HIS HIS GLY VAL TYR SER ARG GLU GLU GLU LEU LEU
SEQRES 13 A 891 ARG GLU ARG LYS ARG LEU GLY VAL PHE GLY ILE THR SER
SEQRES 14 A 891 TYR ASP PHE HIS SER GLU SER GLY LEU PHE LEU PHE GLN
SEQRES 15 A 891 ALA SER ASN SER LEU PHE HIS CYS ARG ASP GLY GLY LYS
SEQRES 16 A 891 ASN GLY PHE MET VAL SER PRO MET LYS PRO LEU GLU ILE
SEQRES 17 A 891 LYS THR GLN CYS SER GLY PRO ARG MET ASP PRO LYS ILE
SEQRES 18 A 891 CYS PRO ALA ASP PRO ALA PHE PHE SER PHE ILE ASN ASN
SEQRES 19 A 891 SER ASP LEU TRP VAL ALA ASN ILE GLU THR GLY GLU GLU
SEQRES 20 A 891 ARG ARG LEU THR PHE CYS HIS GLN GLY LEU SER ASN VAL
SEQRES 21 A 891 LEU ASP ASP PRO LYS SER ALA GLY VAL ALA THR PHE VAL
SEQRES 22 A 891 ILE GLN GLU GLU PHE ASP ARG PHE THR GLY TYR TRP TRP
SEQRES 23 A 891 CYS PRO THR ALA SER TRP GLU GLY SER GLU GLY LEU LYS
SEQRES 24 A 891 THR LEU ARG ILE LEU TYR GLU GLU VAL ASP GLU SER GLU
SEQRES 25 A 891 VAL GLU VAL ILE HIS VAL PRO SER PRO ALA LEU GLU GLU
SEQRES 26 A 891 ARG LYS THR ASP SER TYR ARG TYR PRO ARG THR GLY SER
SEQRES 27 A 891 LYS ASN PRO LYS ILE ALA LEU LYS LEU ALA GLU PHE GLN
SEQRES 28 A 891 THR ASP SER GLN GLY LYS ILE VAL SER THR GLN GLU LYS
SEQRES 29 A 891 GLU LEU VAL GLN PRO PHE SER SER LEU PHE PRO LYS VAL
SEQRES 30 A 891 GLU TYR ILE ALA ARG ALA GLY TRP THR ARG ASP GLY LYS
SEQRES 31 A 891 TYR ALA TRP ALA MET PHE LEU ASP ARG PRO GLN GLN TRP
SEQRES 32 A 891 LEU GLN LEU VAL LEU LEU PRO PRO ALA LEU PHE ILE PRO
SEQRES 33 A 891 SER THR GLU ASN GLU GLU GLN ARG LEU ALA SER ALA ARG
SEQRES 34 A 891 ALA VAL PRO ARG ASN VAL GLN PRO TYR VAL VAL TYR GLU
SEQRES 35 A 891 GLU VAL THR ASN VAL TRP ILE ASN VAL HIS ASP ILE PHE
SEQRES 36 A 891 TYR PRO PHE PRO GLN SER GLU GLY GLU ASP GLU LEU CYS
SEQRES 37 A 891 PHE LEU ARG ALA ASN GLU CYS LYS THR GLY PHE CYS HIS
SEQRES 38 A 891 LEU TYR LYS VAL THR ALA VAL LEU LYS SER GLN GLY TYR
SEQRES 39 A 891 ASP TRP SER GLU PRO PHE SER PRO GLY GLU ASP GLU PHE
SEQRES 40 A 891 LYS CYS PRO ILE LYS GLU GLU ILE ALA LEU THR SER GLY
SEQRES 41 A 891 GLU TRP GLU VAL LEU ALA ARG HIS GLY SER LYS ILE TRP
SEQRES 42 A 891 VAL ASN GLU GLU THR LYS LEU VAL TYR PHE GLN GLY THR
SEQRES 43 A 891 LYS ASP THR PRO LEU GLU HIS HIS LEU TYR VAL VAL SER
SEQRES 44 A 891 TYR GLU ALA ALA GLY GLU ILE VAL ARG LEU THR THR PRO
SEQRES 45 A 891 GLY PHE SER HIS SER CYS SER MET SER GLN ASN PHE ASP
SEQRES 46 A 891 MET PHE VAL SER HIS TYR SER SER VAL SER THR PRO PRO
SEQRES 47 A 891 CYS VAL HIS VAL TYR LYS LEU SER GLY PRO ASP ASP ASP
SEQRES 48 A 891 PRO LEU HIS LYS GLN PRO ARG PHE TRP ALA SER MET MET
SEQRES 49 A 891 GLU ALA ALA SER CYS PRO PRO ASP TYR VAL PRO PRO GLU
SEQRES 50 A 891 ILE PHE HIS PHE HIS THR ARG SER ASP VAL ARG LEU TYR
SEQRES 51 A 891 GLY MET ILE TYR LYS PRO HIS ALA LEU GLN PRO GLY LYS
SEQRES 52 A 891 LYS HIS PRO THR VAL LEU PHE VAL TYR GLY GLY PRO GLN
SEQRES 53 A 891 VAL GLN LEU VAL ASN ASN SER PHE LYS GLY ILE LYS TYR
SEQRES 54 A 891 LEU ARG LEU ASN THR LEU ALA SER LEU GLY TYR ALA VAL
SEQRES 55 A 891 VAL VAL ILE ASP GLY ARG GLY SER CYS GLN ARG GLY LEU
SEQRES 56 A 891 ARG PHE GLU GLY ALA LEU LYS ASN GLN MET GLY GLN VAL
SEQRES 57 A 891 GLU ILE GLU ASP GLN VAL GLU GLY LEU GLN PHE VAL ALA
SEQRES 58 A 891 GLU LYS TYR GLY PHE ILE ASP LEU SER ARG VAL ALA ILE
SEQRES 59 A 891 HIS GLY TRP SER TYR GLY GLY PHE LEU SER LEU MET GLY
SEQRES 60 A 891 LEU ILE HIS LYS PRO GLN VAL PHE LYS VAL ALA ILE ALA
SEQRES 61 A 891 GLY ALA PRO VAL THR VAL TRP MET ALA TYR ASP THR GLY
SEQRES 62 A 891 TYR THR GLU ARG TYR MET ASP VAL PRO GLU ASN ASN GLN
SEQRES 63 A 891 HIS GLY TYR GLU ALA GLY SER VAL ALA LEU HIS VAL GLU
SEQRES 64 A 891 LYS LEU PRO ASN GLU PRO ASN ARG LEU LEU ILE LEU HIS
SEQRES 65 A 891 GLY PHE LEU ASP GLU ASN VAL HIS PHE PHE HIS THR ASN
SEQRES 66 A 891 PHE LEU VAL SER GLN LEU ILE ARG ALA GLY LYS PRO TYR
SEQRES 67 A 891 GLN LEU GLN ILE TYR PRO ASN GLU ARG HIS SER ILE ARG
SEQRES 68 A 891 CYS PRO GLU SER GLY GLU HIS TYR GLU VAL THR LEU LEU
SEQRES 69 A 891 HIS PHE LEU GLN GLU TYR LEU
SEQRES 1 D 891 MET SER TYR TYR HIS HIS HIS HIS HIS HIS ASP TYR ASP
SEQRES 2 D 891 ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY ALA MET
SEQRES 3 D 891 GLY SER MET ALA THR THR GLY THR PRO THR ALA ASP ARG
SEQRES 4 D 891 GLY ASP ALA ALA ALA THR ASP ASP PRO ALA ALA ARG PHE
SEQRES 5 D 891 GLN VAL GLN LYS HIS SER TRP ASP GLY LEU ARG SER ILE
SEQRES 6 D 891 ILE HIS GLY SER ARG LYS TYR SER GLY LEU ILE VAL ASN
SEQRES 7 D 891 LYS ALA PRO HIS ASP PHE GLN PHE VAL GLN LYS THR ASP
SEQRES 8 D 891 GLU SER GLY PRO HIS SER HIS ARG LEU TYR TYR LEU GLY
SEQRES 9 D 891 MET PRO TYR GLY SER ARG GLU ASN SER LEU LEU TYR SER
SEQRES 10 D 891 GLU ILE PRO LYS LYS VAL ARG LYS GLU ALA LEU LEU LEU
SEQRES 11 D 891 LEU SER TRP LYS GLN MET LEU ASP HIS PHE GLN ALA THR
SEQRES 12 D 891 PRO HIS HIS GLY VAL TYR SER ARG GLU GLU GLU LEU LEU
SEQRES 13 D 891 ARG GLU ARG LYS ARG LEU GLY VAL PHE GLY ILE THR SER
SEQRES 14 D 891 TYR ASP PHE HIS SER GLU SER GLY LEU PHE LEU PHE GLN
SEQRES 15 D 891 ALA SER ASN SER LEU PHE HIS CYS ARG ASP GLY GLY LYS
SEQRES 16 D 891 ASN GLY PHE MET VAL SER PRO MET LYS PRO LEU GLU ILE
SEQRES 17 D 891 LYS THR GLN CYS SER GLY PRO ARG MET ASP PRO LYS ILE
SEQRES 18 D 891 CYS PRO ALA ASP PRO ALA PHE PHE SER PHE ILE ASN ASN
SEQRES 19 D 891 SER ASP LEU TRP VAL ALA ASN ILE GLU THR GLY GLU GLU
SEQRES 20 D 891 ARG ARG LEU THR PHE CYS HIS GLN GLY LEU SER ASN VAL
SEQRES 21 D 891 LEU ASP ASP PRO LYS SER ALA GLY VAL ALA THR PHE VAL
SEQRES 22 D 891 ILE GLN GLU GLU PHE ASP ARG PHE THR GLY TYR TRP TRP
SEQRES 23 D 891 CYS PRO THR ALA SER TRP GLU GLY SER GLU GLY LEU LYS
SEQRES 24 D 891 THR LEU ARG ILE LEU TYR GLU GLU VAL ASP GLU SER GLU
SEQRES 25 D 891 VAL GLU VAL ILE HIS VAL PRO SER PRO ALA LEU GLU GLU
SEQRES 26 D 891 ARG LYS THR ASP SER TYR ARG TYR PRO ARG THR GLY SER
SEQRES 27 D 891 LYS ASN PRO LYS ILE ALA LEU LYS LEU ALA GLU PHE GLN
SEQRES 28 D 891 THR ASP SER GLN GLY LYS ILE VAL SER THR GLN GLU LYS
SEQRES 29 D 891 GLU LEU VAL GLN PRO PHE SER SER LEU PHE PRO LYS VAL
SEQRES 30 D 891 GLU TYR ILE ALA ARG ALA GLY TRP THR ARG ASP GLY LYS
SEQRES 31 D 891 TYR ALA TRP ALA MET PHE LEU ASP ARG PRO GLN GLN TRP
SEQRES 32 D 891 LEU GLN LEU VAL LEU LEU PRO PRO ALA LEU PHE ILE PRO
SEQRES 33 D 891 SER THR GLU ASN GLU GLU GLN ARG LEU ALA SER ALA ARG
SEQRES 34 D 891 ALA VAL PRO ARG ASN VAL GLN PRO TYR VAL VAL TYR GLU
SEQRES 35 D 891 GLU VAL THR ASN VAL TRP ILE ASN VAL HIS ASP ILE PHE
SEQRES 36 D 891 TYR PRO PHE PRO GLN SER GLU GLY GLU ASP GLU LEU CYS
SEQRES 37 D 891 PHE LEU ARG ALA ASN GLU CYS LYS THR GLY PHE CYS HIS
SEQRES 38 D 891 LEU TYR LYS VAL THR ALA VAL LEU LYS SER GLN GLY TYR
SEQRES 39 D 891 ASP TRP SER GLU PRO PHE SER PRO GLY GLU ASP GLU PHE
SEQRES 40 D 891 LYS CYS PRO ILE LYS GLU GLU ILE ALA LEU THR SER GLY
SEQRES 41 D 891 GLU TRP GLU VAL LEU ALA ARG HIS GLY SER LYS ILE TRP
SEQRES 42 D 891 VAL ASN GLU GLU THR LYS LEU VAL TYR PHE GLN GLY THR
SEQRES 43 D 891 LYS ASP THR PRO LEU GLU HIS HIS LEU TYR VAL VAL SER
SEQRES 44 D 891 TYR GLU ALA ALA GLY GLU ILE VAL ARG LEU THR THR PRO
SEQRES 45 D 891 GLY PHE SER HIS SER CYS SER MET SER GLN ASN PHE ASP
SEQRES 46 D 891 MET PHE VAL SER HIS TYR SER SER VAL SER THR PRO PRO
SEQRES 47 D 891 CYS VAL HIS VAL TYR LYS LEU SER GLY PRO ASP ASP ASP
SEQRES 48 D 891 PRO LEU HIS LYS GLN PRO ARG PHE TRP ALA SER MET MET
SEQRES 49 D 891 GLU ALA ALA SER CYS PRO PRO ASP TYR VAL PRO PRO GLU
SEQRES 50 D 891 ILE PHE HIS PHE HIS THR ARG SER ASP VAL ARG LEU TYR
SEQRES 51 D 891 GLY MET ILE TYR LYS PRO HIS ALA LEU GLN PRO GLY LYS
SEQRES 52 D 891 LYS HIS PRO THR VAL LEU PHE VAL TYR GLY GLY PRO GLN
SEQRES 53 D 891 VAL GLN LEU VAL ASN ASN SER PHE LYS GLY ILE LYS TYR
SEQRES 54 D 891 LEU ARG LEU ASN THR LEU ALA SER LEU GLY TYR ALA VAL
SEQRES 55 D 891 VAL VAL ILE ASP GLY ARG GLY SER CYS GLN ARG GLY LEU
SEQRES 56 D 891 ARG PHE GLU GLY ALA LEU LYS ASN GLN MET GLY GLN VAL
SEQRES 57 D 891 GLU ILE GLU ASP GLN VAL GLU GLY LEU GLN PHE VAL ALA
SEQRES 58 D 891 GLU LYS TYR GLY PHE ILE ASP LEU SER ARG VAL ALA ILE
SEQRES 59 D 891 HIS GLY TRP SER TYR GLY GLY PHE LEU SER LEU MET GLY
SEQRES 60 D 891 LEU ILE HIS LYS PRO GLN VAL PHE LYS VAL ALA ILE ALA
SEQRES 61 D 891 GLY ALA PRO VAL THR VAL TRP MET ALA TYR ASP THR GLY
SEQRES 62 D 891 TYR THR GLU ARG TYR MET ASP VAL PRO GLU ASN ASN GLN
SEQRES 63 D 891 HIS GLY TYR GLU ALA GLY SER VAL ALA LEU HIS VAL GLU
SEQRES 64 D 891 LYS LEU PRO ASN GLU PRO ASN ARG LEU LEU ILE LEU HIS
SEQRES 65 D 891 GLY PHE LEU ASP GLU ASN VAL HIS PHE PHE HIS THR ASN
SEQRES 66 D 891 PHE LEU VAL SER GLN LEU ILE ARG ALA GLY LYS PRO TYR
SEQRES 67 D 891 GLN LEU GLN ILE TYR PRO ASN GLU ARG HIS SER ILE ARG
SEQRES 68 D 891 CYS PRO GLU SER GLY GLU HIS TYR GLU VAL THR LEU LEU
SEQRES 69 D 891 HIS PHE LEU GLN GLU TYR LEU
SEQRES 1 E 1473 MET ALA GLY GLY ALA TRP GLY ARG LEU ALA CYS TYR LEU
SEQRES 2 E 1473 GLU PHE LEU LYS LYS GLU GLU LEU LYS GLU PHE GLN LEU
SEQRES 3 E 1473 LEU LEU ALA ASN LYS ALA HIS SER ARG SER SER SER GLY
SEQRES 4 E 1473 GLU THR PRO ALA GLN PRO GLU LYS THR SER GLY MET GLU
SEQRES 5 E 1473 VAL ALA SER TYR LEU VAL ALA GLN TYR GLY GLU GLN ARG
SEQRES 6 E 1473 ALA TRP ASP LEU ALA LEU HIS THR TRP GLU GLN MET GLY
SEQRES 7 E 1473 LEU ARG SER LEU CYS ALA GLN ALA GLN GLU GLY ALA GLY
SEQRES 8 E 1473 HIS SER PRO SER PHE PRO TYR SER PRO SER GLU PRO HIS
SEQRES 9 E 1473 LEU GLY SER PRO SER GLN PRO THR SER THR ALA VAL LEU
SEQRES 10 E 1473 MET PRO TRP ILE HIS GLU LEU PRO ALA GLY CYS THR GLN
SEQRES 11 E 1473 GLY SER GLU ARG ARG VAL LEU ARG GLN LEU PRO ASP THR
SEQRES 12 E 1473 SER GLY ARG ARG TRP ARG GLU ILE SER ALA SER LEU LEU
SEQRES 13 E 1473 TYR GLN ALA LEU PRO SER SER PRO ASP HIS GLU SER PRO
SEQRES 14 E 1473 SER GLN GLU SER PRO ASN ALA PRO THR SER THR ALA VAL
SEQRES 15 E 1473 LEU GLY SER TRP GLY SER PRO PRO GLN PRO SER LEU ALA
SEQRES 16 E 1473 PRO ARG GLU GLN GLU ALA PRO GLY THR GLN TRP PRO LEU
SEQRES 17 E 1473 ASP GLU THR SER GLY ILE TYR TYR THR GLU ILE ARG GLU
SEQRES 18 E 1473 ARG GLU ARG GLU LYS SER GLU LYS GLY ARG PRO PRO TRP
SEQRES 19 E 1473 ALA ALA VAL VAL GLY THR PRO PRO GLN ALA HIS THR SER
SEQRES 20 E 1473 LEU GLN PRO HIS HIS HIS PRO TRP GLU PRO SER VAL ARG
SEQRES 21 E 1473 GLU SER LEU CYS SER THR TRP PRO TRP LYS ASN GLU ASP
SEQRES 22 E 1473 PHE ASN GLN LYS PHE THR GLN LEU LEU LEU LEU GLN ARG
SEQRES 23 E 1473 PRO HIS PRO ARG SER GLN ASP PRO LEU VAL LYS ARG SER
SEQRES 24 E 1473 TRP PRO ASP TYR VAL GLU GLU ASN ARG GLY HIS LEU ILE
SEQRES 25 E 1473 GLU ILE ARG ASP LEU PHE GLY PRO GLY LEU ASP THR GLN
SEQRES 26 E 1473 GLU PRO ARG ILE VAL ILE LEU GLN GLY ALA ALA GLY ILE
SEQRES 27 E 1473 GLY LYS SER THR LEU ALA ARG GLN VAL LYS GLU ALA TRP
SEQRES 28 E 1473 GLY ARG GLY GLN LEU TYR GLY ASP ARG PHE GLN HIS VAL
SEQRES 29 E 1473 PHE TYR PHE SER CYS ARG GLU LEU ALA GLN SER LYS VAL
SEQRES 30 E 1473 VAL SER LEU ALA GLU LEU ILE GLY LYS ASP GLY THR ALA
SEQRES 31 E 1473 THR PRO ALA PRO ILE ARG GLN ILE LEU SER ARG PRO GLU
SEQRES 32 E 1473 ARG LEU LEU PHE ILE LEU ASP GLY VAL ASP GLU PRO GLY
SEQRES 33 E 1473 TRP VAL LEU GLN GLU PRO SER SER GLU LEU CYS LEU HIS
SEQRES 34 E 1473 TRP SER GLN PRO GLN PRO ALA ASP ALA LEU LEU GLY SER
SEQRES 35 E 1473 LEU LEU GLY LYS THR ILE LEU PRO GLU ALA SER PHE LEU
SEQRES 36 E 1473 ILE THR ALA ARG THR THR ALA LEU GLN ASN LEU ILE PRO
SEQRES 37 E 1473 SER LEU GLU GLN ALA ARG TRP VAL GLU VAL LEU GLY PHE
SEQRES 38 E 1473 SER GLU SER SER ARG LYS GLU TYR PHE TYR ARG TYR PHE
SEQRES 39 E 1473 THR ASP GLU ARG GLN ALA ILE ARG ALA PHE ARG LEU VAL
SEQRES 40 E 1473 LYS SER ASN LYS GLU LEU TRP ALA LEU CYS LEU VAL PRO
SEQRES 41 E 1473 TRP VAL SER TRP LEU ALA CYS THR CYS LEU MET GLN GLN
SEQRES 42 E 1473 MET LYS ARG LYS GLU LYS LEU THR LEU THR SER LYS THR
SEQRES 43 E 1473 THR THR THR LEU CYS LEU HIS TYR LEU ALA GLN ALA LEU
SEQRES 44 E 1473 GLN ALA GLN PRO LEU GLY PRO GLN LEU ARG ASP LEU CYS
SEQRES 45 E 1473 SER LEU ALA ALA GLU GLY ILE TRP GLN LYS LYS THR LEU
SEQRES 46 E 1473 PHE SER PRO ASP ASP LEU ARG LYS HIS GLY LEU ASP GLY
SEQRES 47 E 1473 ALA ILE ILE SER THR PHE LEU LYS MET GLY ILE LEU GLN
SEQRES 48 E 1473 GLU HIS PRO ILE PRO LEU SER TYR SER PHE ILE HIS LEU
SEQRES 49 E 1473 CYS PHE GLN GLU PHE PHE ALA ALA MET SER TYR VAL LEU
SEQRES 50 E 1473 GLU ASP GLU LYS GLY ARG GLY LYS HIS SER ASN CYS ILE
SEQRES 51 E 1473 ILE ASP LEU GLU LYS THR LEU GLU ALA TYR GLY ILE HIS
SEQRES 52 E 1473 GLY LEU PHE GLY ALA SER THR THR ARG PHE LEU LEU GLY
SEQRES 53 E 1473 LEU LEU SER ASP GLU GLY GLU ARG GLU MET GLU ASN ILE
SEQRES 54 E 1473 PHE HIS CYS ARG LEU SER GLN GLY ARG ASN LEU MET GLN
SEQRES 55 E 1473 TRP VAL PRO SER LEU GLN LEU LEU LEU GLN PRO HIS SER
SEQRES 56 E 1473 LEU GLU SER LEU HIS CYS LEU TYR GLU THR ARG ASN LYS
SEQRES 57 E 1473 THR PHE LEU THR GLN VAL MET ALA HIS PHE GLU GLU MET
SEQRES 58 E 1473 GLY MET CYS VAL GLU THR ASP MET GLU LEU LEU VAL CYS
SEQRES 59 E 1473 THR PHE CYS ILE LYS PHE SER ARG HIS VAL LYS LYS LEU
SEQRES 60 E 1473 GLN LEU ILE GLU GLY ARG GLN HIS ARG SER THR TRP SER
SEQRES 61 E 1473 PRO THR MET VAL VAL LEU PHE ARG TRP VAL PRO VAL THR
SEQRES 62 E 1473 ASP ALA TYR TRP GLN ILE LEU PHE SER VAL LEU LYS VAL
SEQRES 63 E 1473 THR ARG ASN LEU LYS GLU LEU ASP LEU SER GLY ASN SER
SEQRES 64 E 1473 LEU SER HIS SER ALA VAL LYS SER LEU CYS LYS THR LEU
SEQRES 65 E 1473 ARG ARG PRO ARG CYS LEU LEU GLU THR LEU ARG LEU ALA
SEQRES 66 E 1473 GLY CYS GLY LEU THR ALA GLU ASP CYS LYS ASP LEU ALA
SEQRES 67 E 1473 PHE GLY LEU ARG ALA ASN GLN THR LEU THR GLU LEU ASP
SEQRES 68 E 1473 LEU SER PHE ASN VAL LEU THR ASP ALA GLY ALA LYS HIS
SEQRES 69 E 1473 LEU CYS GLN ARG LEU ARG GLN PRO SER CYS LYS LEU GLN
SEQRES 70 E 1473 ARG LEU GLN LEU VAL SER CYS GLY LEU THR SER ASP CYS
SEQRES 71 E 1473 CYS GLN ASP LEU ALA SER VAL LEU SER ALA SER PRO SER
SEQRES 72 E 1473 LEU LYS GLU LEU ASP LEU GLN GLN ASN ASN LEU ASP ASP
SEQRES 73 E 1473 VAL GLY VAL ARG LEU LEU CYS GLU GLY LEU ARG HIS PRO
SEQRES 74 E 1473 ALA CYS LYS LEU ILE ARG LEU GLY LEU ASP GLN THR THR
SEQRES 75 E 1473 LEU SER ASP GLU MET ARG GLN GLU LEU ARG ALA LEU GLU
SEQRES 76 E 1473 GLN GLU LYS PRO GLN LEU LEU ILE PHE SER ARG ARG LYS
SEQRES 77 E 1473 PRO SER VAL MET THR PRO THR GLU GLY LEU ASP THR GLY
SEQRES 78 E 1473 GLU MET SER ASN SER THR SER SER LEU LYS ARG GLN ARG
SEQRES 79 E 1473 LEU GLY SER GLU ARG ALA ALA SER HIS VAL ALA GLN ALA
SEQRES 80 E 1473 ASN LEU LYS LEU LEU ASP VAL SER LYS ILE PHE PRO ILE
SEQRES 81 E 1473 ALA GLU ILE ALA GLU GLU SER SER PRO GLU VAL VAL PRO
SEQRES 82 E 1473 VAL GLU LEU LEU CYS VAL PRO SER PRO ALA SER GLN GLY
SEQRES 83 E 1473 ASP LEU HIS THR LYS PRO LEU GLY THR ASP ASP ASP PHE
SEQRES 84 E 1473 TRP GLY PRO THR GLY PRO VAL ALA THR GLU VAL VAL ASP
SEQRES 85 E 1473 LYS GLU LYS ASN LEU TYR ARG VAL HIS PHE PRO VAL ALA
SEQRES 86 E 1473 GLY SER TYR ARG TRP PRO ASN THR GLY LEU CYS PHE VAL
SEQRES 87 E 1473 MET ARG GLU ALA VAL THR VAL GLU ILE GLU PHE CYS VAL
SEQRES 88 E 1473 TRP ASP GLN PHE LEU GLY GLU ILE ASN PRO GLN HIS SER
SEQRES 89 E 1473 TRP MET VAL ALA GLY PRO LEU LEU ASP ILE LYS ALA GLU
SEQRES 90 E 1473 PRO GLY ALA VAL GLU ALA VAL HIS LEU PRO HIS PHE VAL
SEQRES 91 E 1473 ALA LEU GLN GLY GLY HIS VAL ASP THR SER LEU PHE GLN
SEQRES 92 E 1473 MET ALA HIS PHE LYS GLU GLU GLY MET LEU LEU GLU LYS
SEQRES 93 E 1473 PRO ALA ARG VAL GLU LEU HIS HIS ILE VAL LEU GLU ASN
SEQRES 94 E 1473 PRO SER PHE SER PRO LEU GLY VAL LEU LEU LYS MET ILE
SEQRES 95 E 1473 HIS ASN ALA LEU ARG PHE ILE PRO VAL THR SER VAL VAL
SEQRES 96 E 1473 LEU LEU TYR HIS ARG VAL HIS PRO GLU GLU VAL THR PHE
SEQRES 97 E 1473 HIS LEU TYR LEU ILE PRO SER ASP CYS SER ILE ARG LYS
SEQRES 98 E 1473 ALA ILE ASP ASP LEU GLU MET LYS PHE GLN PHE VAL ARG
SEQRES 99 E 1473 ILE HIS LYS PRO PRO PRO LEU THR PRO LEU TYR MET GLY
SEQRES 100 E 1473 CYS ARG TYR THR VAL SER GLY SER GLY SER GLY MET LEU
SEQRES 101 E 1473 GLU ILE LEU PRO LYS GLU LEU GLU LEU CYS TYR ARG SER
SEQRES 102 E 1473 PRO GLY GLU ASP GLN LEU PHE SER GLU PHE TYR VAL GLY
SEQRES 103 E 1473 HIS LEU GLY SER GLY ILE ARG LEU GLN VAL LYS ASP LYS
SEQRES 104 E 1473 LYS ASP GLU THR LEU VAL TRP GLU ALA LEU VAL LYS PRO
SEQRES 105 E 1473 GLY ASP LEU MET PRO ALA THR THR LEU ILE PRO PRO ALA
SEQRES 106 E 1473 ARG ILE ALA VAL PRO SER PRO LEU ASP ALA PRO GLN LEU
SEQRES 107 E 1473 LEU HIS PHE VAL ASP GLN TYR ARG GLU GLN LEU ILE ALA
SEQRES 108 E 1473 ARG VAL THR SER VAL GLU VAL VAL LEU ASP LYS LEU HIS
SEQRES 109 E 1473 GLY GLN VAL LEU SER GLN GLU GLN TYR GLU ARG VAL LEU
SEQRES 110 E 1473 ALA GLU ASN THR ARG PRO SER GLN MET ARG LYS LEU PHE
SEQRES 111 E 1473 SER LEU SER GLN SER TRP ASP ARG LYS CYS LYS ASP GLY
SEQRES 112 E 1473 LEU TYR GLN ALA LEU LYS GLU THR HIS PRO HIS LEU ILE
SEQRES 113 E 1473 MET GLU LEU TRP GLU LYS GLY SER LYS LYS GLY LEU LEU
SEQRES 114 E 1473 PRO LEU SER SER
SEQRES 1 F 1473 MET ALA GLY GLY ALA TRP GLY ARG LEU ALA CYS TYR LEU
SEQRES 2 F 1473 GLU PHE LEU LYS LYS GLU GLU LEU LYS GLU PHE GLN LEU
SEQRES 3 F 1473 LEU LEU ALA ASN LYS ALA HIS SER ARG SER SER SER GLY
SEQRES 4 F 1473 GLU THR PRO ALA GLN PRO GLU LYS THR SER GLY MET GLU
SEQRES 5 F 1473 VAL ALA SER TYR LEU VAL ALA GLN TYR GLY GLU GLN ARG
SEQRES 6 F 1473 ALA TRP ASP LEU ALA LEU HIS THR TRP GLU GLN MET GLY
SEQRES 7 F 1473 LEU ARG SER LEU CYS ALA GLN ALA GLN GLU GLY ALA GLY
SEQRES 8 F 1473 HIS SER PRO SER PHE PRO TYR SER PRO SER GLU PRO HIS
SEQRES 9 F 1473 LEU GLY SER PRO SER GLN PRO THR SER THR ALA VAL LEU
SEQRES 10 F 1473 MET PRO TRP ILE HIS GLU LEU PRO ALA GLY CYS THR GLN
SEQRES 11 F 1473 GLY SER GLU ARG ARG VAL LEU ARG GLN LEU PRO ASP THR
SEQRES 12 F 1473 SER GLY ARG ARG TRP ARG GLU ILE SER ALA SER LEU LEU
SEQRES 13 F 1473 TYR GLN ALA LEU PRO SER SER PRO ASP HIS GLU SER PRO
SEQRES 14 F 1473 SER GLN GLU SER PRO ASN ALA PRO THR SER THR ALA VAL
SEQRES 15 F 1473 LEU GLY SER TRP GLY SER PRO PRO GLN PRO SER LEU ALA
SEQRES 16 F 1473 PRO ARG GLU GLN GLU ALA PRO GLY THR GLN TRP PRO LEU
SEQRES 17 F 1473 ASP GLU THR SER GLY ILE TYR TYR THR GLU ILE ARG GLU
SEQRES 18 F 1473 ARG GLU ARG GLU LYS SER GLU LYS GLY ARG PRO PRO TRP
SEQRES 19 F 1473 ALA ALA VAL VAL GLY THR PRO PRO GLN ALA HIS THR SER
SEQRES 20 F 1473 LEU GLN PRO HIS HIS HIS PRO TRP GLU PRO SER VAL ARG
SEQRES 21 F 1473 GLU SER LEU CYS SER THR TRP PRO TRP LYS ASN GLU ASP
SEQRES 22 F 1473 PHE ASN GLN LYS PHE THR GLN LEU LEU LEU LEU GLN ARG
SEQRES 23 F 1473 PRO HIS PRO ARG SER GLN ASP PRO LEU VAL LYS ARG SER
SEQRES 24 F 1473 TRP PRO ASP TYR VAL GLU GLU ASN ARG GLY HIS LEU ILE
SEQRES 25 F 1473 GLU ILE ARG ASP LEU PHE GLY PRO GLY LEU ASP THR GLN
SEQRES 26 F 1473 GLU PRO ARG ILE VAL ILE LEU GLN GLY ALA ALA GLY ILE
SEQRES 27 F 1473 GLY LYS SER THR LEU ALA ARG GLN VAL LYS GLU ALA TRP
SEQRES 28 F 1473 GLY ARG GLY GLN LEU TYR GLY ASP ARG PHE GLN HIS VAL
SEQRES 29 F 1473 PHE TYR PHE SER CYS ARG GLU LEU ALA GLN SER LYS VAL
SEQRES 30 F 1473 VAL SER LEU ALA GLU LEU ILE GLY LYS ASP GLY THR ALA
SEQRES 31 F 1473 THR PRO ALA PRO ILE ARG GLN ILE LEU SER ARG PRO GLU
SEQRES 32 F 1473 ARG LEU LEU PHE ILE LEU ASP GLY VAL ASP GLU PRO GLY
SEQRES 33 F 1473 TRP VAL LEU GLN GLU PRO SER SER GLU LEU CYS LEU HIS
SEQRES 34 F 1473 TRP SER GLN PRO GLN PRO ALA ASP ALA LEU LEU GLY SER
SEQRES 35 F 1473 LEU LEU GLY LYS THR ILE LEU PRO GLU ALA SER PHE LEU
SEQRES 36 F 1473 ILE THR ALA ARG THR THR ALA LEU GLN ASN LEU ILE PRO
SEQRES 37 F 1473 SER LEU GLU GLN ALA ARG TRP VAL GLU VAL LEU GLY PHE
SEQRES 38 F 1473 SER GLU SER SER ARG LYS GLU TYR PHE TYR ARG TYR PHE
SEQRES 39 F 1473 THR ASP GLU ARG GLN ALA ILE ARG ALA PHE ARG LEU VAL
SEQRES 40 F 1473 LYS SER ASN LYS GLU LEU TRP ALA LEU CYS LEU VAL PRO
SEQRES 41 F 1473 TRP VAL SER TRP LEU ALA CYS THR CYS LEU MET GLN GLN
SEQRES 42 F 1473 MET LYS ARG LYS GLU LYS LEU THR LEU THR SER LYS THR
SEQRES 43 F 1473 THR THR THR LEU CYS LEU HIS TYR LEU ALA GLN ALA LEU
SEQRES 44 F 1473 GLN ALA GLN PRO LEU GLY PRO GLN LEU ARG ASP LEU CYS
SEQRES 45 F 1473 SER LEU ALA ALA GLU GLY ILE TRP GLN LYS LYS THR LEU
SEQRES 46 F 1473 PHE SER PRO ASP ASP LEU ARG LYS HIS GLY LEU ASP GLY
SEQRES 47 F 1473 ALA ILE ILE SER THR PHE LEU LYS MET GLY ILE LEU GLN
SEQRES 48 F 1473 GLU HIS PRO ILE PRO LEU SER TYR SER PHE ILE HIS LEU
SEQRES 49 F 1473 CYS PHE GLN GLU PHE PHE ALA ALA MET SER TYR VAL LEU
SEQRES 50 F 1473 GLU ASP GLU LYS GLY ARG GLY LYS HIS SER ASN CYS ILE
SEQRES 51 F 1473 ILE ASP LEU GLU LYS THR LEU GLU ALA TYR GLY ILE HIS
SEQRES 52 F 1473 GLY LEU PHE GLY ALA SER THR THR ARG PHE LEU LEU GLY
SEQRES 53 F 1473 LEU LEU SER ASP GLU GLY GLU ARG GLU MET GLU ASN ILE
SEQRES 54 F 1473 PHE HIS CYS ARG LEU SER GLN GLY ARG ASN LEU MET GLN
SEQRES 55 F 1473 TRP VAL PRO SER LEU GLN LEU LEU LEU GLN PRO HIS SER
SEQRES 56 F 1473 LEU GLU SER LEU HIS CYS LEU TYR GLU THR ARG ASN LYS
SEQRES 57 F 1473 THR PHE LEU THR GLN VAL MET ALA HIS PHE GLU GLU MET
SEQRES 58 F 1473 GLY MET CYS VAL GLU THR ASP MET GLU LEU LEU VAL CYS
SEQRES 59 F 1473 THR PHE CYS ILE LYS PHE SER ARG HIS VAL LYS LYS LEU
SEQRES 60 F 1473 GLN LEU ILE GLU GLY ARG GLN HIS ARG SER THR TRP SER
SEQRES 61 F 1473 PRO THR MET VAL VAL LEU PHE ARG TRP VAL PRO VAL THR
SEQRES 62 F 1473 ASP ALA TYR TRP GLN ILE LEU PHE SER VAL LEU LYS VAL
SEQRES 63 F 1473 THR ARG ASN LEU LYS GLU LEU ASP LEU SER GLY ASN SER
SEQRES 64 F 1473 LEU SER HIS SER ALA VAL LYS SER LEU CYS LYS THR LEU
SEQRES 65 F 1473 ARG ARG PRO ARG CYS LEU LEU GLU THR LEU ARG LEU ALA
SEQRES 66 F 1473 GLY CYS GLY LEU THR ALA GLU ASP CYS LYS ASP LEU ALA
SEQRES 67 F 1473 PHE GLY LEU ARG ALA ASN GLN THR LEU THR GLU LEU ASP
SEQRES 68 F 1473 LEU SER PHE ASN VAL LEU THR ASP ALA GLY ALA LYS HIS
SEQRES 69 F 1473 LEU CYS GLN ARG LEU ARG GLN PRO SER CYS LYS LEU GLN
SEQRES 70 F 1473 ARG LEU GLN LEU VAL SER CYS GLY LEU THR SER ASP CYS
SEQRES 71 F 1473 CYS GLN ASP LEU ALA SER VAL LEU SER ALA SER PRO SER
SEQRES 72 F 1473 LEU LYS GLU LEU ASP LEU GLN GLN ASN ASN LEU ASP ASP
SEQRES 73 F 1473 VAL GLY VAL ARG LEU LEU CYS GLU GLY LEU ARG HIS PRO
SEQRES 74 F 1473 ALA CYS LYS LEU ILE ARG LEU GLY LEU ASP GLN THR THR
SEQRES 75 F 1473 LEU SER ASP GLU MET ARG GLN GLU LEU ARG ALA LEU GLU
SEQRES 76 F 1473 GLN GLU LYS PRO GLN LEU LEU ILE PHE SER ARG ARG LYS
SEQRES 77 F 1473 PRO SER VAL MET THR PRO THR GLU GLY LEU ASP THR GLY
SEQRES 78 F 1473 GLU MET SER ASN SER THR SER SER LEU LYS ARG GLN ARG
SEQRES 79 F 1473 LEU GLY SER GLU ARG ALA ALA SER HIS VAL ALA GLN ALA
SEQRES 80 F 1473 ASN LEU LYS LEU LEU ASP VAL SER LYS ILE PHE PRO ILE
SEQRES 81 F 1473 ALA GLU ILE ALA GLU GLU SER SER PRO GLU VAL VAL PRO
SEQRES 82 F 1473 VAL GLU LEU LEU CYS VAL PRO SER PRO ALA SER GLN GLY
SEQRES 83 F 1473 ASP LEU HIS THR LYS PRO LEU GLY THR ASP ASP ASP PHE
SEQRES 84 F 1473 TRP GLY PRO THR GLY PRO VAL ALA THR GLU VAL VAL ASP
SEQRES 85 F 1473 LYS GLU LYS ASN LEU TYR ARG VAL HIS PHE PRO VAL ALA
SEQRES 86 F 1473 GLY SER TYR ARG TRP PRO ASN THR GLY LEU CYS PHE VAL
SEQRES 87 F 1473 MET ARG GLU ALA VAL THR VAL GLU ILE GLU PHE CYS VAL
SEQRES 88 F 1473 TRP ASP GLN PHE LEU GLY GLU ILE ASN PRO GLN HIS SER
SEQRES 89 F 1473 TRP MET VAL ALA GLY PRO LEU LEU ASP ILE LYS ALA GLU
SEQRES 90 F 1473 PRO GLY ALA VAL GLU ALA VAL HIS LEU PRO HIS PHE VAL
SEQRES 91 F 1473 ALA LEU GLN GLY GLY HIS VAL ASP THR SER LEU PHE GLN
SEQRES 92 F 1473 MET ALA HIS PHE LYS GLU GLU GLY MET LEU LEU GLU LYS
SEQRES 93 F 1473 PRO ALA ARG VAL GLU LEU HIS HIS ILE VAL LEU GLU ASN
SEQRES 94 F 1473 PRO SER PHE SER PRO LEU GLY VAL LEU LEU LYS MET ILE
SEQRES 95 F 1473 HIS ASN ALA LEU ARG PHE ILE PRO VAL THR SER VAL VAL
SEQRES 96 F 1473 LEU LEU TYR HIS ARG VAL HIS PRO GLU GLU VAL THR PHE
SEQRES 97 F 1473 HIS LEU TYR LEU ILE PRO SER ASP CYS SER ILE ARG LYS
SEQRES 98 F 1473 ALA ILE ASP ASP LEU GLU MET LYS PHE GLN PHE VAL ARG
SEQRES 99 F 1473 ILE HIS LYS PRO PRO PRO LEU THR PRO LEU TYR MET GLY
SEQRES 100 F 1473 CYS ARG TYR THR VAL SER GLY SER GLY SER GLY MET LEU
SEQRES 101 F 1473 GLU ILE LEU PRO LYS GLU LEU GLU LEU CYS TYR ARG SER
SEQRES 102 F 1473 PRO GLY GLU ASP GLN LEU PHE SER GLU PHE TYR VAL GLY
SEQRES 103 F 1473 HIS LEU GLY SER GLY ILE ARG LEU GLN VAL LYS ASP LYS
SEQRES 104 F 1473 LYS ASP GLU THR LEU VAL TRP GLU ALA LEU VAL LYS PRO
SEQRES 105 F 1473 GLY ASP LEU MET PRO ALA THR THR LEU ILE PRO PRO ALA
SEQRES 106 F 1473 ARG ILE ALA VAL PRO SER PRO LEU ASP ALA PRO GLN LEU
SEQRES 107 F 1473 LEU HIS PHE VAL ASP GLN TYR ARG GLU GLN LEU ILE ALA
SEQRES 108 F 1473 ARG VAL THR SER VAL GLU VAL VAL LEU ASP LYS LEU HIS
SEQRES 109 F 1473 GLY GLN VAL LEU SER GLN GLU GLN TYR GLU ARG VAL LEU
SEQRES 110 F 1473 ALA GLU ASN THR ARG PRO SER GLN MET ARG LYS LEU PHE
SEQRES 111 F 1473 SER LEU SER GLN SER TRP ASP ARG LYS CYS LYS ASP GLY
SEQRES 112 F 1473 LEU TYR GLN ALA LEU LYS GLU THR HIS PRO HIS LEU ILE
SEQRES 113 F 1473 MET GLU LEU TRP GLU LYS GLY SER LYS LYS GLY LEU LEU
SEQRES 114 F 1473 PRO LEU SER SER
HET GK2 A 901 15
HET GK2 D 901 15
HETNAM GK2 [(2~{R})-1-[(2~{R})-2-AZANYL-3-METHYL-
HETNAM 2 GK2 BUTANOYL]PYRROLIDIN-2-YL]BORONIC ACID
FORMUL 5 GK2 2(C9 H19 B N2 O3)
HELIX 1 AA1 ASP A 19 ARG A 23 5 5
HELIX 2 AA2 SER A 30 ARG A 42 1 13
HELIX 3 AA3 TYR A 44 VAL A 49 1 6
HELIX 4 AA4 PRO A 116 VAL A 120 5 5
HELIX 5 AA5 SER A 122 LYS A 132 1 11
HELIX 6 AA6 THR A 243 GLU A 249 1 7
HELIX 7 AA7 ALA A 294 ARG A 298 5 5
HELIX 8 AA8 PRO A 341 PHE A 346 1 6
HELIX 9 AA9 PRO A 382 ALA A 384 5 3
HELIX 10 AB1 ASN A 392 VAL A 403 1 12
HELIX 11 AB2 TYR A 661 GLY A 671 1 11
HELIX 12 AB3 GLY A 686 GLY A 691 1 6
HELIX 13 AB4 ALA A 692 LYS A 694 5 3
HELIX 14 AB5 VAL A 700 TYR A 716 1 17
HELIX 15 AB6 SER A 730 LYS A 743 1 14
HELIX 16 AB7 VAL A 758 TYR A 762 5 5
HELIX 17 AB8 ASP A 763 ASP A 772 1 10
HELIX 18 AB9 ASN A 777 GLY A 784 1 8
HELIX 19 AC1 SER A 785 LEU A 793 5 9
HELIX 20 AC2 HIS A 812 GLY A 827 1 16
HELIX 21 AC3 CYS A 844 LEU A 863 1 20
HELIX 22 AC4 SER D 30 ARG D 42 1 13
HELIX 23 AC5 TYR D 44 VAL D 49 1 6
HELIX 24 AC6 PRO D 116 VAL D 120 5 5
HELIX 25 AC7 SER D 122 ARG D 133 1 12
HELIX 26 AC8 THR D 243 PHE D 250 1 8
HELIX 27 AC9 ALA D 294 ARG D 298 5 5
HELIX 28 AD1 PRO D 341 PHE D 346 1 6
HELIX 29 AD2 PRO D 382 ALA D 384 5 3
HELIX 30 AD3 ASN D 392 VAL D 403 1 12
HELIX 31 AD4 ASP D 583 LYS D 587 5 5
HELIX 32 AD5 TYR D 661 GLY D 671 1 11
HELIX 33 AD6 GLY D 686 GLY D 691 1 6
HELIX 34 AD7 ALA D 692 LYS D 694 5 3
HELIX 35 AD8 VAL D 700 TYR D 716 1 17
HELIX 36 AD9 SER D 730 LYS D 743 1 14
HELIX 37 AE1 VAL D 758 TYR D 762 5 5
HELIX 38 AE2 ASP D 763 MET D 771 1 9
HELIX 39 AE3 ASN D 777 GLY D 784 1 8
HELIX 40 AE4 SER D 785 LEU D 793 5 9
HELIX 41 AE5 PHE D 813 GLY D 827 1 15
HELIX 42 AE6 CYS D 844 LEU D 863 1 20
HELIX 43 AE7 VAL E 1131 ILE E 1139 1 9
HELIX 44 AE8 ASP F 1256 PHE F 1270 1 15
SHEET 1 AA1 4 HIS A 54 GLN A 60 0
SHEET 2 AA1 4 HIS A 68 GLY A 76 -1 O LEU A 75 N HIS A 54
SHEET 3 AA1 4 SER A 85 PRO A 92 -1 O LEU A 87 N TYR A 74
SHEET 4 AA1 4 LYS A 106 GLN A 107 -1 O LYS A 106 N TYR A 88
SHEET 1 AA2 3 LEU A 100 LEU A 102 0
SHEET 2 AA2 3 GLY E1191 GLU E1195 -1 O LEU E1194 N LEU A 100
SHEET 3 AA2 3 MET E1184 LYS E1188 -1 N MET E1184 O GLU E1195
SHEET 1 AA3 4 TYR A 142 HIS A 145 0
SHEET 2 AA3 4 LEU A 150 ALA A 155 -1 O LEU A 152 N ASP A 143
SHEET 3 AA3 4 SER A 158 ARG A 163 -1 O CYS A 162 N PHE A 151
SHEET 4 AA3 4 LEU A 178 ILE A 180 -1 O ILE A 180 N LEU A 159
SHEET 1 AA4 4 ARG A 188 ILE A 193 0
SHEET 2 AA4 4 PHE A 200 ASN A 205 -1 O ILE A 204 N MET A 189
SHEET 3 AA4 4 ASP A 208 ASN A 213 -1 O TRP A 210 N PHE A 203
SHEET 4 AA4 4 GLU A 219 ARG A 221 -1 O ARG A 220 N VAL A 211
SHEET 1 AA5 3 LYS A 237 ALA A 239 0
SHEET 2 AA5 3 LYS A 271 ASP A 281 -1 O VAL A 280 N SER A 238
SHEET 3 AA5 3 SER A 263 TRP A 264 -1 N SER A 263 O THR A 272
SHEET 1 AA6 5 TYR A 256 TRP A 258 0
SHEET 2 AA6 5 LYS A 271 ASP A 281 -1 O LEU A 276 N TRP A 257
SHEET 3 AA6 5 LYS A 314 THR A 324 -1 O ALA A 320 N ILE A 275
SHEET 4 AA6 5 ILE A 330 LEU A 338 -1 O GLN A 334 N GLU A 321
SHEET 5 AA6 5 PHE A 386 PRO A 388 -1 O ILE A 387 N GLU A 337
SHEET 1 AA7 2 VAL A 287 PRO A 291 0
SHEET 2 AA7 2 THR A 300 ARG A 304 -1 O ASP A 301 N VAL A 290
SHEET 1 AA8 4 TYR A 351 TRP A 357 0
SHEET 2 AA8 4 ALA A 364 LEU A 369 -1 O TRP A 365 N GLY A 356
SHEET 3 AA8 4 TRP A 375 LEU A 381 -1 O GLN A 377 N PHE A 368
SHEET 4 AA8 4 TYR A 410 VAL A 416 -1 O GLU A 415 N LEU A 376
SHEET 1 AA9 3 CYS A 440 ASN A 445 0
SHEET 2 AA9 3 HIS A 453 ALA A 459 -1 O VAL A 457 N PHE A 441
SHEET 3 AA9 3 ILE A 483 ALA A 488 -1 O LYS A 484 N THR A 458
SHEET 1 AB1 4 TRP A 505 ASN A 507 0
SHEET 2 AB1 4 LEU A 512 GLY A 517 -1 O TYR A 514 N TRP A 505
SHEET 3 AB1 4 HIS A 526 SER A 531 -1 O VAL A 530 N VAL A 513
SHEET 4 AB1 4 VAL A 539 ARG A 540 -1 O VAL A 539 N VAL A 529
SHEET 1 AB2 4 SER A 547 MET A 552 0
SHEET 2 AB2 4 MET A 558 SER A 564 -1 O SER A 564 N SER A 547
SHEET 3 AB2 4 CYS A 571 SER A 578 -1 O HIS A 573 N SER A 561
SHEET 4 AB2 4 GLN A 588 MET A 596 -1 O ALA A 593 N VAL A 574
SHEET 1 AB3 8 GLU A 609 HIS A 614 0
SHEET 2 AB3 8 ARG A 620 TYR A 626 -1 O ILE A 625 N GLU A 609
SHEET 3 AB3 8 ALA A 673 ILE A 677 -1 O VAL A 676 N MET A 624
SHEET 4 AB3 8 HIS A 637 PHE A 642 1 N VAL A 640 O ALA A 673
SHEET 5 AB3 8 ILE A 719 TRP A 729 1 O ALA A 725 N LEU A 641
SHEET 6 AB3 8 VAL A 749 GLY A 753 1 O ILE A 751 N ILE A 726
SHEET 7 AB3 8 LEU A 800 GLY A 805 1 O LEU A 803 N ALA A 752
SHEET 8 AB3 8 GLN A 831 TYR A 835 1 O GLN A 831 N ILE A 802
SHEET 1 AB4 4 HIS D 54 GLN D 60 0
SHEET 2 AB4 4 HIS D 68 GLY D 76 -1 O LEU D 75 N HIS D 54
SHEET 3 AB4 4 SER D 85 PRO D 92 -1 O LEU D 87 N TYR D 74
SHEET 4 AB4 4 LYS D 106 GLN D 107 -1 O LYS D 106 N TYR D 88
SHEET 1 AB5 4 TYR D 142 HIS D 145 0
SHEET 2 AB5 4 LEU D 150 GLN D 154 -1 O LEU D 152 N ASP D 143
SHEET 3 AB5 4 LEU D 159 CYS D 162 -1 O CYS D 162 N PHE D 151
SHEET 4 AB5 4 LEU D 178 ILE D 180 -1 O ILE D 180 N LEU D 159
SHEET 1 AB6 4 MET D 189 ILE D 193 0
SHEET 2 AB6 4 PHE D 200 ASN D 205 -1 O ILE D 204 N MET D 189
SHEET 3 AB6 4 ASP D 208 ASN D 213 -1 O TRP D 210 N PHE D 203
SHEET 4 AB6 4 GLU D 219 ARG D 221 -1 O ARG D 220 N VAL D 211
SHEET 1 AB7 5 LYS D 237 ALA D 239 0
SHEET 2 AB7 5 ILE D 275 ASP D 281 -1 O VAL D 280 N SER D 238
SHEET 3 AB7 5 LYS D 314 THR D 324 -1 O LYS D 318 N TYR D 277
SHEET 4 AB7 5 LYS D 271 LEU D 273 -1 N LYS D 271 O THR D 324
SHEET 5 AB7 5 SER D 263 TRP D 264 -1 N SER D 263 O THR D 272
SHEET 1 AB8 5 TYR D 256 TRP D 258 0
SHEET 2 AB8 5 ILE D 275 ASP D 281 -1 O LEU D 276 N TRP D 257
SHEET 3 AB8 5 LYS D 314 THR D 324 -1 O LYS D 318 N TYR D 277
SHEET 4 AB8 5 ILE D 330 LEU D 338 -1 O GLN D 334 N GLU D 321
SHEET 5 AB8 5 PHE D 386 PRO D 388 -1 O ILE D 387 N GLU D 337
SHEET 1 AB9 2 VAL D 287 PRO D 291 0
SHEET 2 AB9 2 THR D 300 ARG D 304 -1 O ASP D 301 N VAL D 290
SHEET 1 AC1 4 TYR D 351 ALA D 355 0
SHEET 2 AC1 4 ALA D 364 LEU D 369 -1 O MET D 367 N ARG D 354
SHEET 3 AC1 4 TRP D 375 LEU D 381 -1 O GLN D 377 N PHE D 368
SHEET 4 AC1 4 TYR D 410 VAL D 416 -1 O GLU D 415 N LEU D 376
SHEET 1 AC2 4 PHE D 427 PRO D 429 0
SHEET 2 AC2 4 LEU D 439 ASN D 445 -1 O LEU D 442 N TYR D 428
SHEET 3 AC2 4 HIS D 453 ALA D 459 -1 O VAL D 457 N PHE D 441
SHEET 4 AC2 4 ILE D 483 ALA D 488 -1 O LYS D 484 N THR D 458
SHEET 1 AC3 4 TRP D 505 ASN D 507 0
SHEET 2 AC3 4 LEU D 512 GLY D 517 -1 O TYR D 514 N TRP D 505
SHEET 3 AC3 4 HIS D 526 SER D 531 -1 O TYR D 528 N PHE D 515
SHEET 4 AC3 4 VAL D 539 ARG D 540 -1 O VAL D 539 N VAL D 529
SHEET 1 AC4 4 SER D 547 MET D 552 0
SHEET 2 AC4 4 MET D 558 SER D 564 -1 O SER D 564 N SER D 547
SHEET 3 AC4 4 CYS D 571 SER D 578 -1 O CYS D 571 N TYR D 563
SHEET 4 AC4 4 GLN D 588 MET D 596 -1 O ALA D 593 N VAL D 574
SHEET 1 AC5 8 GLU D 609 HIS D 614 0
SHEET 2 AC5 8 ARG D 620 TYR D 626 -1 O GLY D 623 N PHE D 611
SHEET 3 AC5 8 ALA D 673 ILE D 677 -1 O VAL D 676 N MET D 624
SHEET 4 AC5 8 HIS D 637 VAL D 643 1 N VAL D 640 O ALA D 673
SHEET 5 AC5 8 ILE D 719 TRP D 729 1 O ALA D 725 N LEU D 641
SHEET 6 AC5 8 VAL D 749 GLY D 753 1 O GLY D 753 N GLY D 728
SHEET 7 AC5 8 LEU D 800 GLY D 805 1 O LEU D 803 N ALA D 752
SHEET 8 AC5 8 GLN D 831 TYR D 835 1 O GLN D 831 N ILE D 802
SHEET 1 AC6 2 TRP E1080 GLY E1081 0
SHEET 2 AC6 2 GLY E1084 PRO E1085 -1 O GLY E1084 N GLY E1081
SHEET 1 AC7 4 GLU E1089 ASP E1092 0
SHEET 2 AC7 4 LEU E1097 PHE E1102 -1 O ARG E1099 N GLU E1089
SHEET 3 AC7 4 VAL E1123 PHE E1129 -1 O ILE E1127 N TYR E1098
SHEET 4 AC7 4 LEU E1152 LYS E1155 -1 O ASP E1153 N GLU E1128
SHEET 1 AC8 4 CYS E1116 VAL E1118 0
SHEET 2 AC8 4 ALA E1163 LEU E1166 -1 O ALA E1163 N VAL E1118
SHEET 3 AC8 4 ILE E1205 VAL E1206 -1 O ILE E1205 N LEU E1166
SHEET 4 AC8 4 ARG E1199 VAL E1200 -1 N ARG E1199 O VAL E1206
SHEET 1 AC9 2 TRP E1145 VAL E1147 0
SHEET 2 AC9 2 LEU F1218 LYS F1220 -1 O LEU F1219 N MET E1146
SHEET 1 AD1 2 PRO F1230 VAL F1231 0
SHEET 2 AD1 2 LEU F1284 TYR F1285 -1 O LEU F1284 N VAL F1231
SHEET 1 AD2 3 VAL F1234 LEU F1236 0
SHEET 2 AD2 3 VAL F1246 ILE F1253 -1 O TYR F1251 N LEU F1236
SHEET 3 AD2 3 PHE F1320 GLY F1326 -1 O SER F1321 N LEU F1250
SHEET 1 AD3 2 TYR F1238 HIS F1239 0
SHEET 2 AD3 2 VAL F1273 ARG F1274 -1 O VAL F1273 N HIS F1239
SHEET 1 AD4 4 GLU F1306 GLU F1308 0
SHEET 2 AD4 4 ARG F1289 GLY F1294 -1 N TYR F1290 O LEU F1307
SHEET 3 AD4 4 ARG F1333 ASP F1338 -1 O GLN F1335 N SER F1293
SHEET 4 AD4 4 LEU F1344 LEU F1349 -1 O TRP F1346 N VAL F1336
LINK OG SER A 730 B15 GK2 A 901 1555 1555 1.41
LINK OG SER D 730 B15 GK2 D 901 1555 1555 1.40
CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1
ORIGX1 1.000000 0.000000 0.000000 0.00000
ORIGX2 0.000000 1.000000 0.000000 0.00000
ORIGX3 0.000000 0.000000 1.000000 0.00000
SCALE1 1.000000 0.000000 0.000000 0.00000
SCALE2 0.000000 1.000000 0.000000 0.00000
SCALE3 0.000000 0.000000 1.000000 0.00000
TER 6817 LEU A 863
TER 13634 LEU D 863
TER 14703 PHE E1212
TER 15809 VAL F1350
MASTER 2970 0 2 44 119 0 0 615835 4 32 366
END |