longtext: 6xs3-pdb

content
HEADER    LIPID BINDING PROTEIN                   14-JUL-20   6XS3
TITLE     X-RAY STRUCTURE OF THE MONOCLINIC CRYSTAL FORM AT 2.48 A RESOLUTION OF
TITLE    2 LIPASE FROM THERMOMYCES (HUMICOLA) LANUGINOSA AT 298 K
CAVEAT     6XS3    LTV A 304 HAS WRONG CHIRALITY AT ATOM C19 LTV F 304 HAS
CAVEAT   2 6XS3    WRONG CHIRALITY AT ATOM C19
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: LIPASE;
COMPND   3 CHAIN: A, B, C, E, D, F;
COMPND   4 SYNONYM: TRIACYLGLYCEROL LIPASE;
COMPND   5 EC: 3.1.1.3;
COMPND   6 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: THERMOMYCES LANUGINOSUS;
SOURCE   3 ORGANISM_TAXID: 5541;
SOURCE   4 GENE: LIP;
SOURCE   5 EXPRESSION_SYSTEM: ASPERGILLUS ACULEATINUS;
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 487661
KEYWDS    SUBSTRATE COMPLEX, DIACYLGLYCEROL, COVALENT INTERMEDIATE, INTERFACIAL
KEYWDS   2 ACTIVATION, LIPID BINDING PROTEIN
EXPDTA    X-RAY DIFFRACTION
AUTHOR    A.MCPHERSON
REVDAT   1   14-OCT-20 6XS3    0
JRNL        AUTH   A.MCPHERSON,S.B.LARSON,A.KALASKY
JRNL        TITL   THE CRYSTAL STRUCTURES OF THERMOMYCES (HUMICOLA) LANUGINOSA
JRNL        TITL 2 LIPASE IN COMPLEX WITH ENZYMATIC REACTANTS
JRNL        REF    CURRENT ENZYME INHIBITION     V.  16       2020
JRNL        DOI    10.2174/1573408016999200511090910
REMARK   2
REMARK   2 RESOLUTION.    2.48 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX 1.18.2_3874
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : ML
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.48
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 51.27
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.340
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.5
REMARK   3   NUMBER OF REFLECTIONS             : 61661
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.180
REMARK   3   R VALUE            (WORKING SET) : 0.178
REMARK   3   FREE R VALUE                     : 0.213
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.910
REMARK   3   FREE R VALUE TEST SET COUNT      : 3025
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 51.2700 -  6.9500    1.00     2751   151  0.1576 0.1671
REMARK   3     2  6.9400 -  5.5100    1.00     2717   131  0.1512 0.1756
REMARK   3     3  5.5100 -  4.8200    1.00     2703   126  0.1293 0.1529
REMARK   3     4  4.8200 -  4.3800    1.00     2711   145  0.1150 0.1685
REMARK   3     5  4.3800 -  4.0600    1.00     2682   133  0.1296 0.1598
REMARK   3     6  4.0600 -  3.8300    1.00     2685   128  0.1390 0.1961
REMARK   3     7  3.8200 -  3.6300    1.00     2685   125  0.1425 0.1722
REMARK   3     8  3.6300 -  3.4800    1.00     2704   124  0.1533 0.1730
REMARK   3     9  3.4800 -  3.3400    1.00     2658   144  0.1754 0.2186
REMARK   3    10  3.3400 -  3.2300    1.00     2675   137  0.1776 0.2365
REMARK   3    11  3.2300 -  3.1300    1.00     2653   141  0.1885 0.2323
REMARK   3    12  3.1300 -  3.0400    1.00     2677   134  0.1940 0.2304
REMARK   3    13  3.0400 -  2.9600    1.00     2650   153  0.2044 0.2411
REMARK   3    14  2.9600 -  2.8800    1.00     2672   143  0.2086 0.2606
REMARK   3    15  2.8800 -  2.8200    1.00     2652   137  0.2263 0.2445
REMARK   3    16  2.8200 -  2.7600    1.00     2647   147  0.2353 0.2610
REMARK   3    17  2.7600 -  2.7000    1.00     2648   142  0.2467 0.2887
REMARK   3    18  2.7000 -  2.6500    0.99     2659   147  0.2594 0.2883
REMARK   3    19  2.6500 -  2.6000    0.99     2627   135  0.2688 0.3072
REMARK   3    20  2.6000 -  2.5600    0.99     2683   121  0.2791 0.3290
REMARK   3    21  2.5600 -  2.5200    0.98     2564   150  0.2958 0.2762
REMARK   3    22  2.5200 -  2.4800    0.94     2533   131  0.3140 0.3480
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL
REMARK   3   SOLVENT RADIUS     : 1.11
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.320
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 21.190
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 26.00
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 36.12
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :   NULL           NULL
REMARK   3   ANGLE     :   NULL           NULL
REMARK   3   CHIRALITY :   NULL           NULL
REMARK   3   PLANARITY :   NULL           NULL
REMARK   3   DIHEDRAL  :   NULL           NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: STRUCTURE WAS REFINED TO CONVERGENCE
REMARK   3  WITH REFMAC5 IN CCP4, THEN FIVE RUNS THROUGH PHENIX REFINE USING
REMARK   3  ISOTROPIC B VALUES AND NO TLS.
REMARK   4
REMARK   4 6XS3 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 15-JUL-20.
REMARK 100 THE DEPOSITION ID IS D_1000250658.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 20-JUN-17
REMARK 200  TEMPERATURE           (KELVIN) : 298
REMARK 200  PH                             : 6.0 - 7.0
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : N
REMARK 200  RADIATION SOURCE               : ROTATING ANODE
REMARK 200  BEAMLINE                       : NULL
REMARK 200  X-RAY GENERATOR MODEL          : RIGAKU MICROMAX-007 HF
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.5419
REMARK 200  MONOCHROMATOR                  : OSMIC MIRRORS
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : OXFORD RUBY CCD
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : MOSFLM
REMARK 200  DATA SCALING SOFTWARE          : AIMLESS
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 81074
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.480
REMARK 200  RESOLUTION RANGE LOW       (A) : 75.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 100.0
REMARK 200  DATA REDUNDANCY                : 9.600
REMARK 200  R MERGE                    (I) : 0.29200
REMARK 200  R SYM                      (I) : 0.28700
REMARK 200   FOR THE DATA SET  : 7.1000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.48
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.55
REMARK 200  COMPLETENESS FOR SHELL     (%) : 96.2
REMARK 200  DATA REDUNDANCY IN SHELL       : 3.90
REMARK 200  R MERGE FOR SHELL          (I) : 1.02000
REMARK 200  R SYM FOR SHELL            (I) : 1.01000
REMARK 200   FOR SHELL         : 1.300
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: 4EA6
REMARK 200
REMARK 200 REMARK: CUBE SHAPED BLOCKS
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 46.91
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.32
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: CXRYSTALS WERE GROWN BY SITTING DROP
REMARK 280  IN CRYSCHEM PLATES USING 0.6 ML RESERVOIRS OF 20% PEG 3350 IN
REMARK 280  0.1M MES BUFFER. THE DROPS WERE 6 UL COMPOSED OF EQUAL AMOUNTS
REMARK 280  OF PROTEIN AT 30 MG/ML IN WATER WITH THE RESERVOIR SOLUTION.
REMARK 280  TEMPERATURE WAS 298 K AND CRYSTALS APPEARED AFTER ABOUT TWO
REMARK 280  WEEKS, PH 6.5, VAPOR DIFFUSION, SITTING DROP
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000       45.68300
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TRIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 6360 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 29450 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -57.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, D, F
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TRIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 6730 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 29160 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -69.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B, C, E
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A   -21
REMARK 465     ARG A   -20
REMARK 465     SER A   -19
REMARK 465     SER A   -18
REMARK 465     LEU A   -17
REMARK 465     VAL A   -16
REMARK 465     LEU A   -15
REMARK 465     PHE A   -14
REMARK 465     PHE A   -13
REMARK 465     VAL A   -12
REMARK 465     SER A   -11
REMARK 465     ALA A   -10
REMARK 465     TRP A    -9
REMARK 465     THR A    -8
REMARK 465     ALA A    -7
REMARK 465     LEU A    -6
REMARK 465     ALA A    -5
REMARK 465     SER A    -4
REMARK 465     PRO A    -3
REMARK 465     ILE A    -2
REMARK 465     ARG A    -1
REMARK 465     ARG A     0
REMARK 465     MET B   -21
REMARK 465     ARG B   -20
REMARK 465     SER B   -19
REMARK 465     SER B   -18
REMARK 465     LEU B   -17
REMARK 465     VAL B   -16
REMARK 465     LEU B   -15
REMARK 465     PHE B   -14
REMARK 465     PHE B   -13
REMARK 465     VAL B   -12
REMARK 465     SER B   -11
REMARK 465     ALA B   -10
REMARK 465     TRP B    -9
REMARK 465     THR B    -8
REMARK 465     ALA B    -7
REMARK 465     LEU B    -6
REMARK 465     ALA B    -5
REMARK 465     SER B    -4
REMARK 465     PRO B    -3
REMARK 465     ILE B    -2
REMARK 465     ARG B    -1
REMARK 465     ARG B     0
REMARK 465     MET C   -21
REMARK 465     ARG C   -20
REMARK 465     SER C   -19
REMARK 465     SER C   -18
REMARK 465     LEU C   -17
REMARK 465     VAL C   -16
REMARK 465     LEU C   -15
REMARK 465     PHE C   -14
REMARK 465     PHE C   -13
REMARK 465     VAL C   -12
REMARK 465     SER C   -11
REMARK 465     ALA C   -10
REMARK 465     TRP C    -9
REMARK 465     THR C    -8
REMARK 465     ALA C    -7
REMARK 465     LEU C    -6
REMARK 465     ALA C    -5
REMARK 465     SER C    -4
REMARK 465     PRO C    -3
REMARK 465     ILE C    -2
REMARK 465     ARG C    -1
REMARK 465     ARG C     0
REMARK 465     MET E   -21
REMARK 465     ARG E   -20
REMARK 465     SER E   -19
REMARK 465     SER E   -18
REMARK 465     LEU E   -17
REMARK 465     VAL E   -16
REMARK 465     LEU E   -15
REMARK 465     PHE E   -14
REMARK 465     PHE E   -13
REMARK 465     VAL E   -12
REMARK 465     SER E   -11
REMARK 465     ALA E   -10
REMARK 465     TRP E    -9
REMARK 465     THR E    -8
REMARK 465     ALA E    -7
REMARK 465     LEU E    -6
REMARK 465     ALA E    -5
REMARK 465     SER E    -4
REMARK 465     PRO E    -3
REMARK 465     ILE E    -2
REMARK 465     ARG E    -1
REMARK 465     ARG E     0
REMARK 465     MET D   -21
REMARK 465     ARG D   -20
REMARK 465     SER D   -19
REMARK 465     SER D   -18
REMARK 465     LEU D   -17
REMARK 465     VAL D   -16
REMARK 465     LEU D   -15
REMARK 465     PHE D   -14
REMARK 465     PHE D   -13
REMARK 465     VAL D   -12
REMARK 465     SER D   -11
REMARK 465     ALA D   -10
REMARK 465     TRP D    -9
REMARK 465     THR D    -8
REMARK 465     ALA D    -7
REMARK 465     LEU D    -6
REMARK 465     ALA D    -5
REMARK 465     SER D    -4
REMARK 465     PRO D    -3
REMARK 465     ILE D    -2
REMARK 465     ARG D    -1
REMARK 465     ARG D     0
REMARK 465     MET F   -21
REMARK 465     ARG F   -20
REMARK 465     SER F   -19
REMARK 465     SER F   -18
REMARK 465     LEU F   -17
REMARK 465     VAL F   -16
REMARK 465     LEU F   -15
REMARK 465     PHE F   -14
REMARK 465     PHE F   -13
REMARK 465     VAL F   -12
REMARK 465     SER F   -11
REMARK 465     ALA F   -10
REMARK 465     TRP F    -9
REMARK 465     THR F    -8
REMARK 465     ALA F    -7
REMARK 465     LEU F    -6
REMARK 465     ALA F    -5
REMARK 465     SER F    -4
REMARK 465     PRO F    -3
REMARK 465     ILE F    -2
REMARK 465     ARG F    -1
REMARK 465     ARG F     0
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     ALA A 173    CB
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   HG   SER E    83    HD21  ASN E    92              1.21
REMARK 500   H    ARG D   209     O    HOH D   405              1.36
REMARK 500   HG   SER D   224     O    HOH D   403              1.43
REMARK 500   H    SER C    83     O1   OCA C   301              1.45
REMARK 500   HZ1  LYS A    98     CG   ASP A   111              1.56
REMARK 500   HE   ARG D    84     O    HOH D   408              1.57
REMARK 500   O    PHE A    95     HH   TYR A   213              1.58
REMARK 500   OG   SER F   146     C1   OCA F   301              1.58
REMARK 500   OG   SER C   146     C1   OCA C   301              1.60
REMARK 500   OE1  GLU D    87     O    HOH D   401              1.60
REMARK 500   O    HOH B   447     O    HOH B   469              1.74
REMARK 500   OG   SER E   146     C1   OCA E   301              1.76
REMARK 500   O    HOH A   401     O    HOH A   414              1.83
REMARK 500   C5   OCA B   301     C32  LTV B   306              1.84
REMARK 500   OD1  ASP A    57     O    HOH A   401              1.90
REMARK 500   OG   SER A   146     C2   OCA A   301              1.92
REMARK 500   OG   SER F   146     O1   OCA F   301              1.92
REMARK 500   NE2  HIS E   258     O1   OCA E   301              1.93
REMARK 500   OG   SER E   146     NE2  HIS E   258              2.02
REMARK 500   O    HOH E   411     O    HOH E   423              2.02
REMARK 500   O    THR B   244     O    HOH B   401              2.03
REMARK 500   O    HOH F   401     O    HOH F   416              2.03
REMARK 500   OG   SER A    83     O1   OCA A   301              2.04
REMARK 500   OG   SER C   146     O1   OCA C   301              2.04
REMARK 500   O    HOH B   407     O    HOH B   435              2.07
REMARK 500   O    ALA B    30     O    HOH B   402              2.07
REMARK 500   O    HOH A   410     O    HOH A   414              2.07
REMARK 500   O3   PO4 A   305     O    HOH A   402              2.08
REMARK 500   OD1  ASP B    96     CD2  LEU C   227              2.08
REMARK 500   OD1  ASP B    57     O    HOH B   403              2.08
REMARK 500   OE1  GLU D    45     O    HOH D   402              2.09
REMARK 500   OG1  THR A    37     O    HOH A   403              2.10
REMARK 500   OD1  ASP F    57     O    HOH F   401              2.10
REMARK 500   O    HOH A   401     O    HOH A   404              2.11
REMARK 500   OXT  LEU C   269     O    HOH C   401              2.11
REMARK 500   OG   SER D   224     O    HOH D   403              2.11
REMARK 500   OG   SER B   146     O1   OCA B   301              2.11
REMARK 500   OG   SER D   146     O1   OCA D   301              2.12
REMARK 500   NZ   LYS A    98     OD1  ASP A   111              2.12
REMARK 500   O    HOH E   445     O    HOH E   448              2.12
REMARK 500   OD1  ASP B    57     O    HOH B   404              2.13
REMARK 500   O    SER D   214     O    HOH D   404              2.15
REMARK 500   O4   PO4 D   305     O    HOH D   401              2.15
REMARK 500   OXT  LEU F   269     O    HOH F   402              2.16
REMARK 500   O    HOH B   403     O    HOH B   404              2.17
REMARK 500   OE2  GLU F    45     O    HOH F   403              2.19
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    ARG A  84      -38.20   -135.50
REMARK 500    SER A 146     -123.75     62.48
REMARK 500    THR A 199     -118.72     32.92
REMARK 500    PHE A 262      -39.75     73.72
REMARK 500    ASN B  39       31.29    -92.47
REMARK 500    CYS B  41       59.87   -147.50
REMARK 500    ARG B  84      -48.19   -144.18
REMARK 500    SER B 146     -130.03     61.85
REMARK 500    THR B 199     -117.85     34.46
REMARK 500    ASN B 251     -164.18    -77.43
REMARK 500    PHE B 262      -40.23     72.28
REMARK 500    ASP C  27       33.61   -141.51
REMARK 500    ASN C  39       31.82    -97.20
REMARK 500    ASP C  62       62.13     64.54
REMARK 500    ARG C  84      -42.00   -139.04
REMARK 500    SER C 146     -121.35     52.60
REMARK 500    THR C 199     -115.07     29.36
REMARK 500    PHE C 262      -42.33     75.52
REMARK 500    ASN E  39       35.05    -98.26
REMARK 500    ARG E  84      -47.08   -144.33
REMARK 500    SER E 146     -126.52     61.42
REMARK 500    THR E 199     -120.62     32.52
REMARK 500    PHE E 262      -33.13     73.09
REMARK 500    ASP D  27       35.69   -142.32
REMARK 500    CYS D  41       59.30   -145.16
REMARK 500    ARG D  84      -43.73   -146.39
REMARK 500    HIS D 110      126.05    -38.77
REMARK 500    SER D 146     -132.39     58.87
REMARK 500    THR D 199     -118.33     32.82
REMARK 500    ASN D 251     -167.08   -112.38
REMARK 500    PHE D 262      -43.89     68.80
REMARK 500    ASP F  27       71.54   -153.93
REMARK 500    CYS F  41       58.70   -144.59
REMARK 500    ARG F  84      -44.46   -139.08
REMARK 500    SER F 146     -125.61     58.87
REMARK 500    THR F 199     -117.33     33.59
REMARK 500    PRO F 250       46.48    -83.80
REMARK 500    PHE F 262      -30.25     74.12
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: PLANAR GROUPS
REMARK 500
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS
REMARK 500 AN RMSD GREATER THAN THIS VALUE
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500  M RES CSSEQI        RMS     TYPE
REMARK 500    ARG A 108         0.29    SIDE CHAIN
REMARK 500    ARG D 118         0.19    SIDE CHAIN
REMARK 500
REMARK 500 REMARK: NULL
REMARK 525
REMARK 525 SOLVENT
REMARK 525
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 525 NUMBER; I=INSERTION CODE):
REMARK 525
REMARK 525  M RES CSSEQI
REMARK 525    HOH F 481        DISTANCE =  8.68 ANGSTROMS
REMARK 610
REMARK 610 MISSING HETEROATOM
REMARK 610 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 610 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 610 I=INSERTION CODE):
REMARK 610   M RES C SSEQI
REMARK 610     LTV A  304
REMARK 610     LTV B  306
REMARK 610     OCA C  301
REMARK 610     NAG C  304
REMARK 610     LTV C  305
REMARK 610     OCA E  301
REMARK 610     NAG E  303
REMARK 610     LTV E  304
REMARK 610     OCA F  301
REMARK 610     NAG F  303
REMARK 610     LTV F  304
REMARK 620
REMARK 620 METAL COORDINATION
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA A 302  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 GLU A  45   O
REMARK 620 2 ALA A  47   O    71.7
REMARK 620 N                    1
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA B 303  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 GLU B  45   O
REMARK 620 2 ALA B  47   O    71.1
REMARK 620 3 HOH B 410   O    85.2  59.9
REMARK 620 4 HOH B 425   O    77.4  71.3 131.2
REMARK 620 5 HOH B 448   O    94.7 137.8 161.0  66.8
REMARK 620 6 HOH B 450   O   146.5  81.7  98.0  75.7  92.6
REMARK 620 N                    1     2     3     4     5
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA B 304  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 ASP B  62   OD2
REMARK 620 2 HOH B 403   O    55.7
REMARK 620 3 HOH B 404   O   108.1  55.6
REMARK 620 4 HOH B 406   O    63.4  59.3  66.2
REMARK 620 5 HOH B 467   O   121.9 158.9 129.7 141.2
REMARK 620 N                    1     2     3     4
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA C 302  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 GLU C  45   O
REMARK 620 2 ALA C  47   O    74.9
REMARK 620 3 HOH C 409   O    96.9  62.4
REMARK 620 4 HOH C 433   O   147.9  83.1  93.0
REMARK 620 5 HOH C 452   O    89.7  69.7 127.7  60.5
REMARK 620 6 HOH C 473   O    94.2 145.6 152.0  91.0  77.8
REMARK 620 N                    1     2     3     4     5
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA C 303  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 HOH C 405   O
REMARK 620 2 HOH C 466   O    53.0
REMARK 620 3 HOH C 475   O   114.6  67.0
REMARK 620 4 HOH C 479   O   119.1 129.7 118.1
REMARK 620 N                    1     2     3
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA E 302  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 ASN E  33   OD1
REMARK 620 2 GLU E  45   O   157.5
REMARK 620 3 ALA E  47   O   126.2  65.9
REMARK 620 N                    1     2
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA D 302  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 GLU D  45   O
REMARK 620 2 ALA D  47   O    69.4
REMARK 620 3 HOH D 426   O    76.4  72.3
REMARK 620 N                    1     2
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA F 302  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 GLU F  45   O
REMARK 620 2 ALA F  47   O    76.4
REMARK 620 3 HOH F 417   O    88.6  80.9
REMARK 620 N                    1     2
DBREF  6XS3 A  -21   269  UNP    O59952   LIP_THELA        1    291
DBREF  6XS3 B  -21   269  UNP    O59952   LIP_THELA        1    291
DBREF  6XS3 C  -21   269  UNP    O59952   LIP_THELA        1    291
DBREF  6XS3 E  -21   269  UNP    O59952   LIP_THELA        1    291
DBREF  6XS3 D  -21   269  UNP    O59952   LIP_THELA        1    291
DBREF  6XS3 F  -21   269  UNP    O59952   LIP_THELA        1    291
SEQRES   1 A  291  MET ARG SER SER LEU VAL LEU PHE PHE VAL SER ALA TRP
SEQRES   2 A  291  THR ALA LEU ALA SER PRO ILE ARG ARG GLU VAL SER GLN
SEQRES   3 A  291  ASP LEU PHE ASN GLN PHE ASN LEU PHE ALA GLN TYR SER
SEQRES   4 A  291  ALA ALA ALA TYR CYS GLY LYS ASN ASN ASP ALA PRO ALA
SEQRES   5 A  291  GLY THR ASN ILE THR CYS THR GLY ASN ALA CYS PRO GLU
SEQRES   6 A  291  VAL GLU LYS ALA ASP ALA THR PHE LEU TYR SER PHE GLU
SEQRES   7 A  291  ASP SER GLY VAL GLY ASP VAL THR GLY PHE LEU ALA LEU
SEQRES   8 A  291  ASP ASN THR ASN LYS LEU ILE VAL LEU SER PHE ARG GLY
SEQRES   9 A  291  SER ARG SER ILE GLU ASN TRP ILE GLY ASN LEU ASN PHE
SEQRES  10 A  291  ASP LEU LYS GLU ILE ASN ASP ILE CYS SER GLY CYS ARG
SEQRES  11 A  291  GLY HIS ASP GLY PHE THR SER SER TRP ARG SER VAL ALA
SEQRES  12 A  291  ASP THR LEU ARG GLN LYS VAL GLU ASP ALA VAL ARG GLU
SEQRES  13 A  291  HIS PRO ASP TYR ARG VAL VAL PHE THR GLY HIS SER LEU
SEQRES  14 A  291  GLY GLY ALA LEU ALA THR VAL ALA GLY ALA ASP LEU ARG
SEQRES  15 A  291  GLY ASN GLY TYR ASP ILE ASP VAL PHE SER TYR GLY ALA
SEQRES  16 A  291  PRO ARG VAL GLY ASN ARG ALA PHE ALA GLU PHE LEU THR
SEQRES  17 A  291  VAL GLN THR GLY GLY THR LEU TYR ARG ILE THR HIS THR
SEQRES  18 A  291  ASN ASP ILE VAL PRO ARG LEU PRO PRO ARG GLU PHE GLY
SEQRES  19 A  291  TYR SER HIS SER SER PRO GLU TYR TRP ILE LYS SER GLY
SEQRES  20 A  291  THR LEU VAL PRO VAL THR ARG ASN ASP ILE VAL LYS ILE
SEQRES  21 A  291  GLU GLY ILE ASP ALA THR GLY GLY ASN ASN GLN PRO ASN
SEQRES  22 A  291  ILE PRO ASP ILE PRO ALA HIS LEU TRP TYR PHE GLY LEU
SEQRES  23 A  291  ILE GLY THR CYS LEU
SEQRES   1 B  291  MET ARG SER SER LEU VAL LEU PHE PHE VAL SER ALA TRP
SEQRES   2 B  291  THR ALA LEU ALA SER PRO ILE ARG ARG GLU VAL SER GLN
SEQRES   3 B  291  ASP LEU PHE ASN GLN PHE ASN LEU PHE ALA GLN TYR SER
SEQRES   4 B  291  ALA ALA ALA TYR CYS GLY LYS ASN ASN ASP ALA PRO ALA
SEQRES   5 B  291  GLY THR ASN ILE THR CYS THR GLY ASN ALA CYS PRO GLU
SEQRES   6 B  291  VAL GLU LYS ALA ASP ALA THR PHE LEU TYR SER PHE GLU
SEQRES   7 B  291  ASP SER GLY VAL GLY ASP VAL THR GLY PHE LEU ALA LEU
SEQRES   8 B  291  ASP ASN THR ASN LYS LEU ILE VAL LEU SER PHE ARG GLY
SEQRES   9 B  291  SER ARG SER ILE GLU ASN TRP ILE GLY ASN LEU ASN PHE
SEQRES  10 B  291  ASP LEU LYS GLU ILE ASN ASP ILE CYS SER GLY CYS ARG
SEQRES  11 B  291  GLY HIS ASP GLY PHE THR SER SER TRP ARG SER VAL ALA
SEQRES  12 B  291  ASP THR LEU ARG GLN LYS VAL GLU ASP ALA VAL ARG GLU
SEQRES  13 B  291  HIS PRO ASP TYR ARG VAL VAL PHE THR GLY HIS SER LEU
SEQRES  14 B  291  GLY GLY ALA LEU ALA THR VAL ALA GLY ALA ASP LEU ARG
SEQRES  15 B  291  GLY ASN GLY TYR ASP ILE ASP VAL PHE SER TYR GLY ALA
SEQRES  16 B  291  PRO ARG VAL GLY ASN ARG ALA PHE ALA GLU PHE LEU THR
SEQRES  17 B  291  VAL GLN THR GLY GLY THR LEU TYR ARG ILE THR HIS THR
SEQRES  18 B  291  ASN ASP ILE VAL PRO ARG LEU PRO PRO ARG GLU PHE GLY
SEQRES  19 B  291  TYR SER HIS SER SER PRO GLU TYR TRP ILE LYS SER GLY
SEQRES  20 B  291  THR LEU VAL PRO VAL THR ARG ASN ASP ILE VAL LYS ILE
SEQRES  21 B  291  GLU GLY ILE ASP ALA THR GLY GLY ASN ASN GLN PRO ASN
SEQRES  22 B  291  ILE PRO ASP ILE PRO ALA HIS LEU TRP TYR PHE GLY LEU
SEQRES  23 B  291  ILE GLY THR CYS LEU
SEQRES   1 C  291  MET ARG SER SER LEU VAL LEU PHE PHE VAL SER ALA TRP
SEQRES   2 C  291  THR ALA LEU ALA SER PRO ILE ARG ARG GLU VAL SER GLN
SEQRES   3 C  291  ASP LEU PHE ASN GLN PHE ASN LEU PHE ALA GLN TYR SER
SEQRES   4 C  291  ALA ALA ALA TYR CYS GLY LYS ASN ASN ASP ALA PRO ALA
SEQRES   5 C  291  GLY THR ASN ILE THR CYS THR GLY ASN ALA CYS PRO GLU
SEQRES   6 C  291  VAL GLU LYS ALA ASP ALA THR PHE LEU TYR SER PHE GLU
SEQRES   7 C  291  ASP SER GLY VAL GLY ASP VAL THR GLY PHE LEU ALA LEU
SEQRES   8 C  291  ASP ASN THR ASN LYS LEU ILE VAL LEU SER PHE ARG GLY
SEQRES   9 C  291  SER ARG SER ILE GLU ASN TRP ILE GLY ASN LEU ASN PHE
SEQRES  10 C  291  ASP LEU LYS GLU ILE ASN ASP ILE CYS SER GLY CYS ARG
SEQRES  11 C  291  GLY HIS ASP GLY PHE THR SER SER TRP ARG SER VAL ALA
SEQRES  12 C  291  ASP THR LEU ARG GLN LYS VAL GLU ASP ALA VAL ARG GLU
SEQRES  13 C  291  HIS PRO ASP TYR ARG VAL VAL PHE THR GLY HIS SER LEU
SEQRES  14 C  291  GLY GLY ALA LEU ALA THR VAL ALA GLY ALA ASP LEU ARG
SEQRES  15 C  291  GLY ASN GLY TYR ASP ILE ASP VAL PHE SER TYR GLY ALA
SEQRES  16 C  291  PRO ARG VAL GLY ASN ARG ALA PHE ALA GLU PHE LEU THR
SEQRES  17 C  291  VAL GLN THR GLY GLY THR LEU TYR ARG ILE THR HIS THR
SEQRES  18 C  291  ASN ASP ILE VAL PRO ARG LEU PRO PRO ARG GLU PHE GLY
SEQRES  19 C  291  TYR SER HIS SER SER PRO GLU TYR TRP ILE LYS SER GLY
SEQRES  20 C  291  THR LEU VAL PRO VAL THR ARG ASN ASP ILE VAL LYS ILE
SEQRES  21 C  291  GLU GLY ILE ASP ALA THR GLY GLY ASN ASN GLN PRO ASN
SEQRES  22 C  291  ILE PRO ASP ILE PRO ALA HIS LEU TRP TYR PHE GLY LEU
SEQRES  23 C  291  ILE GLY THR CYS LEU
SEQRES   1 E  291  MET ARG SER SER LEU VAL LEU PHE PHE VAL SER ALA TRP
SEQRES   2 E  291  THR ALA LEU ALA SER PRO ILE ARG ARG GLU VAL SER GLN
SEQRES   3 E  291  ASP LEU PHE ASN GLN PHE ASN LEU PHE ALA GLN TYR SER
SEQRES   4 E  291  ALA ALA ALA TYR CYS GLY LYS ASN ASN ASP ALA PRO ALA
SEQRES   5 E  291  GLY THR ASN ILE THR CYS THR GLY ASN ALA CYS PRO GLU
SEQRES   6 E  291  VAL GLU LYS ALA ASP ALA THR PHE LEU TYR SER PHE GLU
SEQRES   7 E  291  ASP SER GLY VAL GLY ASP VAL THR GLY PHE LEU ALA LEU
SEQRES   8 E  291  ASP ASN THR ASN LYS LEU ILE VAL LEU SER PHE ARG GLY
SEQRES   9 E  291  SER ARG SER ILE GLU ASN TRP ILE GLY ASN LEU ASN PHE
SEQRES  10 E  291  ASP LEU LYS GLU ILE ASN ASP ILE CYS SER GLY CYS ARG
SEQRES  11 E  291  GLY HIS ASP GLY PHE THR SER SER TRP ARG SER VAL ALA
SEQRES  12 E  291  ASP THR LEU ARG GLN LYS VAL GLU ASP ALA VAL ARG GLU
SEQRES  13 E  291  HIS PRO ASP TYR ARG VAL VAL PHE THR GLY HIS SER LEU
SEQRES  14 E  291  GLY GLY ALA LEU ALA THR VAL ALA GLY ALA ASP LEU ARG
SEQRES  15 E  291  GLY ASN GLY TYR ASP ILE ASP VAL PHE SER TYR GLY ALA
SEQRES  16 E  291  PRO ARG VAL GLY ASN ARG ALA PHE ALA GLU PHE LEU THR
SEQRES  17 E  291  VAL GLN THR GLY GLY THR LEU TYR ARG ILE THR HIS THR
SEQRES  18 E  291  ASN ASP ILE VAL PRO ARG LEU PRO PRO ARG GLU PHE GLY
SEQRES  19 E  291  TYR SER HIS SER SER PRO GLU TYR TRP ILE LYS SER GLY
SEQRES  20 E  291  THR LEU VAL PRO VAL THR ARG ASN ASP ILE VAL LYS ILE
SEQRES  21 E  291  GLU GLY ILE ASP ALA THR GLY GLY ASN ASN GLN PRO ASN
SEQRES  22 E  291  ILE PRO ASP ILE PRO ALA HIS LEU TRP TYR PHE GLY LEU
SEQRES  23 E  291  ILE GLY THR CYS LEU
SEQRES   1 D  291  MET ARG SER SER LEU VAL LEU PHE PHE VAL SER ALA TRP
SEQRES   2 D  291  THR ALA LEU ALA SER PRO ILE ARG ARG GLU VAL SER GLN
SEQRES   3 D  291  ASP LEU PHE ASN GLN PHE ASN LEU PHE ALA GLN TYR SER
SEQRES   4 D  291  ALA ALA ALA TYR CYS GLY LYS ASN ASN ASP ALA PRO ALA
SEQRES   5 D  291  GLY THR ASN ILE THR CYS THR GLY ASN ALA CYS PRO GLU
SEQRES   6 D  291  VAL GLU LYS ALA ASP ALA THR PHE LEU TYR SER PHE GLU
SEQRES   7 D  291  ASP SER GLY VAL GLY ASP VAL THR GLY PHE LEU ALA LEU
SEQRES   8 D  291  ASP ASN THR ASN LYS LEU ILE VAL LEU SER PHE ARG GLY
SEQRES   9 D  291  SER ARG SER ILE GLU ASN TRP ILE GLY ASN LEU ASN PHE
SEQRES  10 D  291  ASP LEU LYS GLU ILE ASN ASP ILE CYS SER GLY CYS ARG
SEQRES  11 D  291  GLY HIS ASP GLY PHE THR SER SER TRP ARG SER VAL ALA
SEQRES  12 D  291  ASP THR LEU ARG GLN LYS VAL GLU ASP ALA VAL ARG GLU
SEQRES  13 D  291  HIS PRO ASP TYR ARG VAL VAL PHE THR GLY HIS SER LEU
SEQRES  14 D  291  GLY GLY ALA LEU ALA THR VAL ALA GLY ALA ASP LEU ARG
SEQRES  15 D  291  GLY ASN GLY TYR ASP ILE ASP VAL PHE SER TYR GLY ALA
SEQRES  16 D  291  PRO ARG VAL GLY ASN ARG ALA PHE ALA GLU PHE LEU THR
SEQRES  17 D  291  VAL GLN THR GLY GLY THR LEU TYR ARG ILE THR HIS THR
SEQRES  18 D  291  ASN ASP ILE VAL PRO ARG LEU PRO PRO ARG GLU PHE GLY
SEQRES  19 D  291  TYR SER HIS SER SER PRO GLU TYR TRP ILE LYS SER GLY
SEQRES  20 D  291  THR LEU VAL PRO VAL THR ARG ASN ASP ILE VAL LYS ILE
SEQRES  21 D  291  GLU GLY ILE ASP ALA THR GLY GLY ASN ASN GLN PRO ASN
SEQRES  22 D  291  ILE PRO ASP ILE PRO ALA HIS LEU TRP TYR PHE GLY LEU
SEQRES  23 D  291  ILE GLY THR CYS LEU
SEQRES   1 F  291  MET ARG SER SER LEU VAL LEU PHE PHE VAL SER ALA TRP
SEQRES   2 F  291  THR ALA LEU ALA SER PRO ILE ARG ARG GLU VAL SER GLN
SEQRES   3 F  291  ASP LEU PHE ASN GLN PHE ASN LEU PHE ALA GLN TYR SER
SEQRES   4 F  291  ALA ALA ALA TYR CYS GLY LYS ASN ASN ASP ALA PRO ALA
SEQRES   5 F  291  GLY THR ASN ILE THR CYS THR GLY ASN ALA CYS PRO GLU
SEQRES   6 F  291  VAL GLU LYS ALA ASP ALA THR PHE LEU TYR SER PHE GLU
SEQRES   7 F  291  ASP SER GLY VAL GLY ASP VAL THR GLY PHE LEU ALA LEU
SEQRES   8 F  291  ASP ASN THR ASN LYS LEU ILE VAL LEU SER PHE ARG GLY
SEQRES   9 F  291  SER ARG SER ILE GLU ASN TRP ILE GLY ASN LEU ASN PHE
SEQRES  10 F  291  ASP LEU LYS GLU ILE ASN ASP ILE CYS SER GLY CYS ARG
SEQRES  11 F  291  GLY HIS ASP GLY PHE THR SER SER TRP ARG SER VAL ALA
SEQRES  12 F  291  ASP THR LEU ARG GLN LYS VAL GLU ASP ALA VAL ARG GLU
SEQRES  13 F  291  HIS PRO ASP TYR ARG VAL VAL PHE THR GLY HIS SER LEU
SEQRES  14 F  291  GLY GLY ALA LEU ALA THR VAL ALA GLY ALA ASP LEU ARG
SEQRES  15 F  291  GLY ASN GLY TYR ASP ILE ASP VAL PHE SER TYR GLY ALA
SEQRES  16 F  291  PRO ARG VAL GLY ASN ARG ALA PHE ALA GLU PHE LEU THR
SEQRES  17 F  291  VAL GLN THR GLY GLY THR LEU TYR ARG ILE THR HIS THR
SEQRES  18 F  291  ASN ASP ILE VAL PRO ARG LEU PRO PRO ARG GLU PHE GLY
SEQRES  19 F  291  TYR SER HIS SER SER PRO GLU TYR TRP ILE LYS SER GLY
SEQRES  20 F  291  THR LEU VAL PRO VAL THR ARG ASN ASP ILE VAL LYS ILE
SEQRES  21 F  291  GLU GLY ILE ASP ALA THR GLY GLY ASN ASN GLN PRO ASN
SEQRES  22 F  291  ILE PRO ASP ILE PRO ALA HIS LEU TRP TYR PHE GLY LEU
SEQRES  23 F  291  ILE GLY THR CYS LEU
HET    OCA  A 301       9
HET     CA  A 302       1
HET    NAG  A 303      27
HET    LTV  A 304      36
HET    PO4  A 305       5
HET    OCA  B 301       9
HET    PO4  B 302       5
HET     CA  B 303       1
HET     CA  B 304       1
HET    NAG  B 305      27
HET    LTV  B 306      43
HET    PO4  B 307       5
HET    OCA  C 301       9
HET     CA  C 302       1
HET     CA  C 303       1
HET    NAG  C 304      27
HET    LTV  C 305      41
HET    OCA  E 301       9
HET     CA  E 302       1
HET    NAG  E 303      27
HET    LTV  E 304      48
HET    PO4  E 305       5
HET    OCA  D 301       9
HET     CA  D 302       1
HET    NAG  D 303      27
HET    LTV  D 304      51
HET    PO4  D 305       5
HET    OCA  F 301       7
HET     CA  F 302       1
HET    NAG  F 303      27
HET    LTV  F 304      42
HETNAM     OCA OCTANOIC ACID (CAPRYLIC ACID)
HETNAM      CA CALCIUM ION
HETNAM     NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE
HETNAM     LTV 2-HYDROXY-3-(OCTADECANOYLOXY)PROPYL PENTACOSANOATE
HETNAM     PO4 PHOSPHATE ION
HETSYN     NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA-
HETSYN   2 NAG  D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO-
HETSYN   3 NAG  2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE
FORMUL   7  OCA    6(C8 H16 O2)
FORMUL   8   CA    8(CA 2+)
FORMUL   9  NAG    6(C8 H15 N O6)
FORMUL  10  LTV    6(C46 H90 O5)
FORMUL  11  PO4    5(O4 P 3-)
FORMUL  38  HOH   *428(H2 O)
HELIX    1 AA1 SER A    3  ALA A   20  1                                  18
HELIX    2 AA2 TYR A   21  ASN A   26  5                                   6
HELIX    3 AA3 CYS A   41  ALA A   47  1                                   7
HELIX    4 AA4 SER A   85  LEU A   93  1                                   9
HELIX    5 AA5 ASP A  111  HIS A  135  1                                  25
HELIX    6 AA6 SER A  146  ARG A  160  1                                  15
HELIX    7 AA7 ASN A  178  GLN A  188  1                                  11
HELIX    8 AA8 ILE A  202  LEU A  206  5                                   5
HELIX    9 AA9 PRO A  208  GLY A  212  5                                   5
HELIX   10 AB1 THR A  231  ASN A  233  5                                   3
HELIX   11 AB2 ILE A  255  TRP A  260  5                                   6
HELIX   12 AB3 SER B    3  ALA B   20  1                                  18
HELIX   13 AB4 TYR B   21  ASN B   26  5                                   6
HELIX   14 AB5 CYS B   41  ALA B   47  1                                   7
HELIX   15 AB6 SER B   85  LEU B   93  1                                   9
HELIX   16 AB7 ASP B  111  HIS B  135  1                                  25
HELIX   17 AB8 SER B  146  ARG B  160  1                                  15
HELIX   18 AB9 ASN B  178  GLN B  188  1                                  11
HELIX   19 AC1 ILE B  202  LEU B  206  5                                   5
HELIX   20 AC2 PRO B  208  GLY B  212  5                                   5
HELIX   21 AC3 THR B  231  ASN B  233  5                                   3
HELIX   22 AC4 ILE B  255  TRP B  260  5                                   6
HELIX   23 AC5 SER C    3  ALA C   20  1                                  18
HELIX   24 AC6 TYR C   21  ASN C   26  5                                   6
HELIX   25 AC7 CYS C   41  ALA C   47  1                                   7
HELIX   26 AC8 SER C   85  ASN C   94  1                                  10
HELIX   27 AC9 ASP C  111  SER C  119  1                                   9
HELIX   28 AD1 VAL C  120  HIS C  135  1                                  16
HELIX   29 AD2 SER C  146  ARG C  160  1                                  15
HELIX   30 AD3 ASN C  178  GLN C  188  1                                  11
HELIX   31 AD4 ILE C  202  LEU C  206  5                                   5
HELIX   32 AD5 PRO C  208  GLY C  212  5                                   5
HELIX   33 AD6 THR C  231  ASN C  233  5                                   3
HELIX   34 AD7 ILE C  255  TRP C  260  5                                   6
HELIX   35 AD8 SER E    3  ALA E   20  1                                  18
HELIX   36 AD9 TYR E   21  ASP E   27  5                                   7
HELIX   37 AE1 CYS E   41  ALA E   47  1                                   7
HELIX   38 AE2 SER E   85  LEU E   93  1                                   9
HELIX   39 AE3 ASP E  111  HIS E  135  1                                  25
HELIX   40 AE4 SER E  146  ARG E  160  1                                  15
HELIX   41 AE5 ASN E  178  GLN E  188  1                                  11
HELIX   42 AE6 ILE E  202  LEU E  206  5                                   5
HELIX   43 AE7 PRO E  208  GLY E  212  5                                   5
HELIX   44 AE8 THR E  231  ASN E  233  5                                   3
HELIX   45 AE9 ILE E  255  TRP E  260  5                                   6
HELIX   46 AF1 SER D    3  ALA D   20  1                                  18
HELIX   47 AF2 TYR D   21  ASN D   26  5                                   6
HELIX   48 AF3 CYS D   41  ALA D   47  1                                   7
HELIX   49 AF4 SER D   85  ASN D   94  1                                  10
HELIX   50 AF5 ASP D  111  HIS D  135  1                                  25
HELIX   51 AF6 SER D  146  ARG D  160  1                                  15
HELIX   52 AF7 ASN D  178  GLN D  188  1                                  11
HELIX   53 AF8 ILE D  202  LEU D  206  5                                   5
HELIX   54 AF9 PRO D  208  GLY D  212  5                                   5
HELIX   55 AG1 ILE D  255  TRP D  260  5                                   6
HELIX   56 AG2 SER F    3  CYS F   22  1                                  20
HELIX   57 AG3 GLY F   23  ASP F   27  5                                   5
HELIX   58 AG4 CYS F   41  ALA F   47  1                                   7
HELIX   59 AG5 SER F   85  LEU F   93  1                                   9
HELIX   60 AG6 ASP F  111  SER F  119  1                                   9
HELIX   61 AG7 VAL F  120  HIS F  135  1                                  16
HELIX   62 AG8 SER F  146  ARG F  160  1                                  15
HELIX   63 AG9 ASN F  178  GLN F  188  1                                  11
HELIX   64 AH1 ILE F  202  LEU F  206  5                                   5
HELIX   65 AH2 PRO F  208  GLY F  212  5                                   5
HELIX   66 AH3 THR F  231  ASN F  233  5                                   3
HELIX   67 AH4 ILE F  255  TRP F  260  5                                   6
SHEET    1 AA1 8 ALA A  49  SER A  58  0
SHEET    2 AA1 8 VAL A  63  ASP A  70 -1  O  LEU A  67   N  LEU A  52
SHEET    3 AA1 8 LEU A  75  PHE A  80 -1  O  VAL A  77   N  ALA A  68
SHEET    4 AA1 8 ARG A 139  HIS A 145  1  O  VAL A 141   N  ILE A  76
SHEET    5 AA1 8 ILE A 166  TYR A 171  1  O  ASP A 167   N  PHE A 142
SHEET    6 AA1 8 LEU A 193  HIS A 198  1  O  TYR A 194   N  VAL A 168
SHEET    7 AA1 8 GLU A 219  ILE A 222  1  O  TYR A 220   N  THR A 197
SHEET    8 AA1 8 ILE A 235  ILE A 238 -1  O  ILE A 238   N  GLU A 219
SHEET    1 AA2 2 LEU A  97  GLU A  99  0
SHEET    2 AA2 2 ARG A 108  HIS A 110 -1  O  GLY A 109   N  LYS A  98
SHEET    1 AA3 8 ALA B  49  SER B  58  0
SHEET    2 AA3 8 VAL B  63  ASP B  70 -1  O  LEU B  67   N  TYR B  53
SHEET    3 AA3 8 LEU B  75  PHE B  80 -1  O  VAL B  77   N  ALA B  68
SHEET    4 AA3 8 ARG B 139  HIS B 145  1  O  VAL B 141   N  ILE B  76
SHEET    5 AA3 8 ILE B 166  TYR B 171  1  O  ASP B 167   N  PHE B 142
SHEET    6 AA3 8 LEU B 193  HIS B 198  1  O  TYR B 194   N  VAL B 168
SHEET    7 AA3 8 GLU B 219  ILE B 222  1  O  ILE B 222   N  THR B 197
SHEET    8 AA3 8 ILE B 235  ILE B 238 -1  O  ILE B 238   N  GLU B 219
SHEET    1 AA4 2 LEU B  97  GLU B  99  0
SHEET    2 AA4 2 ARG B 108  HIS B 110 -1  O  GLY B 109   N  LYS B  98
SHEET    1 AA5 8 ALA C  49  SER C  58  0
SHEET    2 AA5 8 VAL C  63  ASP C  70 -1  O  LEU C  67   N  TYR C  53
SHEET    3 AA5 8 LEU C  75  PHE C  80 -1  O  VAL C  77   N  ALA C  68
SHEET    4 AA5 8 ARG C 139  HIS C 145  1  O  ARG C 139   N  ILE C  76
SHEET    5 AA5 8 ILE C 166  TYR C 171  1  O  ASP C 167   N  PHE C 142
SHEET    6 AA5 8 LEU C 193  HIS C 198  1  O  TYR C 194   N  VAL C 168
SHEET    7 AA5 8 GLU C 219  ILE C 222  1  O  TYR C 220   N  ARG C 195
SHEET    8 AA5 8 ILE C 235  ILE C 238 -1  O  ILE C 238   N  GLU C 219
SHEET    1 AA6 2 LEU C  97  GLU C  99  0
SHEET    2 AA6 2 ARG C 108  HIS C 110 -1  O  GLY C 109   N  LYS C  98
SHEET    1 AA7 8 ALA E  49  SER E  58  0
SHEET    2 AA7 8 VAL E  63  ASP E  70 -1  O  LEU E  67   N  LEU E  52
SHEET    3 AA7 8 LEU E  75  PHE E  80 -1  O  VAL E  77   N  ALA E  68
SHEET    4 AA7 8 ARG E 139  HIS E 145  1  O  ARG E 139   N  ILE E  76
SHEET    5 AA7 8 ILE E 166  TYR E 171  1  O  ASP E 167   N  PHE E 142
SHEET    6 AA7 8 LEU E 193  HIS E 198  1  O  TYR E 194   N  VAL E 168
SHEET    7 AA7 8 GLU E 219  ILE E 222  1  O  ILE E 222   N  THR E 197
SHEET    8 AA7 8 ILE E 235  ILE E 238 -1  O  VAL E 236   N  TRP E 221
SHEET    1 AA8 2 LEU E  97  GLU E  99  0
SHEET    2 AA8 2 ARG E 108  HIS E 110 -1  O  GLY E 109   N  LYS E  98
SHEET    1 AA9 8 ALA D  49  SER D  58  0
SHEET    2 AA9 8 VAL D  63  ASP D  70 -1  O  LEU D  67   N  TYR D  53
SHEET    3 AA9 8 LEU D  75  PHE D  80 -1  O  VAL D  77   N  ALA D  68
SHEET    4 AA9 8 ARG D 139  HIS D 145  1  O  THR D 143   N  LEU D  78
SHEET    5 AA9 8 ILE D 166  TYR D 171  1  O  ASP D 167   N  PHE D 142
SHEET    6 AA9 8 LEU D 193  HIS D 198  1  O  TYR D 194   N  VAL D 168
SHEET    7 AA9 8 GLU D 219  ILE D 222  1  O  ILE D 222   N  THR D 197
SHEET    8 AA9 8 ILE D 235  ILE D 238 -1  O  VAL D 236   N  TRP D 221
SHEET    1 AB1 2 LEU D  97  GLU D  99  0
SHEET    2 AB1 2 ARG D 108  HIS D 110 -1  O  GLY D 109   N  LYS D  98
SHEET    1 AB2 8 ALA F  49  SER F  58  0
SHEET    2 AB2 8 VAL F  63  ASP F  70 -1  O  LEU F  67   N  TYR F  53
SHEET    3 AB2 8 LEU F  75  PHE F  80 -1  O  VAL F  77   N  ALA F  68
SHEET    4 AB2 8 ARG F 139  HIS F 145  1  O  VAL F 141   N  ILE F  76
SHEET    5 AB2 8 ILE F 166  TYR F 171  1  O  ASP F 167   N  PHE F 142
SHEET    6 AB2 8 LEU F 193  HIS F 198  1  O  TYR F 194   N  VAL F 168
SHEET    7 AB2 8 GLU F 219  ILE F 222  1  O  ILE F 222   N  THR F 197
SHEET    8 AB2 8 ILE F 235  ILE F 238 -1  O  ILE F 238   N  GLU F 219
SHEET    1 AB3 2 LEU F  97  GLU F  99  0
SHEET    2 AB3 2 ARG F 108  HIS F 110 -1  O  GLY F 109   N  LYS F  98
SSBOND   1 CYS A   22    CYS A  268                          1555   1555  2.03
SSBOND   2 CYS A   36    CYS A   41                          1555   1555  2.03
SSBOND   3 CYS A  104    CYS A  107                          1555   1555  2.03
SSBOND   4 CYS B   22    CYS B  268                          1555   1555  2.03
SSBOND   5 CYS B   36    CYS B   41                          1555   1555  2.03
SSBOND   6 CYS B  104    CYS B  107                          1555   1555  2.03
SSBOND   7 CYS C   22    CYS C  268                          1555   1555  2.03
SSBOND   8 CYS C   36    CYS C   41                          1555   1555  2.03
SSBOND   9 CYS C  104    CYS C  107                          1555   1555  2.03
SSBOND  10 CYS E   22    CYS E  268                          1555   1555  2.03
SSBOND  11 CYS E   36    CYS E   41                          1555   1555  2.03
SSBOND  12 CYS E  104    CYS E  107                          1555   1555  2.03
SSBOND  13 CYS D   22    CYS D  268                          1555   1555  2.03
SSBOND  14 CYS D   36    CYS D   41                          1555   1555  2.02
SSBOND  15 CYS D  104    CYS D  107                          1555   1555  2.04
SSBOND  16 CYS F   22    CYS F  268                          1555   1555  2.03
SSBOND  17 CYS F   36    CYS F   41                          1555   1555  2.03
SSBOND  18 CYS F  104    CYS F  107                          1555   1555  2.03
LINK         ND2 ASN A  33                 C1  NAG A 303     1555   1555  1.42
LINK         OG  SER A 146                 C1  OCA A 301     1555   1555  1.38
LINK         ND2 ASN B  33                 C1  NAG B 305     1555   1555  1.42
LINK         OG  SER B 146                 C1  OCA B 301     1555   1555  1.37
LINK         C5  OCA B 301                 C33 LTV B 306     1555   1555  1.64
LINK         O   SER E  83                 C6  OCA E 301     1555   1555  1.31
LINK         OD1 ASN D  33                 C1  NAG D 303     1555   1555  1.47
LINK         OG  SER D 146                 C1  OCA D 301     1555   1555  1.37
LINK         C5  OCA D 301                 C31 LTV D 304     1555   1555  1.49
LINK         O   GLU A  45                CA    CA A 302     1555   1555  2.56
LINK         O   ALA A  47                CA    CA A 302     1555   1555  2.56
LINK         O   GLU B  45                CA    CA B 303     1555   1555  2.53
LINK         O   ALA B  47                CA    CA B 303     1555   1555  2.60
LINK         OD2 ASP B  62                CA    CA B 304     1555   1555  3.04
LINK        CA    CA B 303                 O   HOH B 410     1555   1555  2.12
LINK        CA    CA B 303                 O   HOH B 425     1555   1555  2.59
LINK        CA    CA B 303                 O   HOH B 448     1555   1555  2.56
LINK        CA    CA B 303                 O   HOH B 450     1555   1555  2.41
LINK        CA    CA B 304                 O   HOH B 403     1555   1555  2.23
LINK        CA    CA B 304                 O   HOH B 404     1555   1555  2.41
LINK        CA    CA B 304                 O   HOH B 406     1555   1555  2.35
LINK        CA    CA B 304                 O   HOH B 467     1555   1555  2.26
LINK         O   GLU C  45                CA    CA C 302     1555   1555  2.59
LINK         O   ALA C  47                CA    CA C 302     1555   1555  2.66
LINK        CA    CA C 302                 O   HOH C 409     1555   1555  3.17
LINK        CA    CA C 302                 O   HOH C 433     1555   1555  2.70
LINK        CA    CA C 302                 O   HOH C 452     1555   1555  2.48
LINK        CA    CA C 302                 O   HOH C 473     1555   1555  2.37
LINK        CA    CA C 303                 O   HOH C 405     1555   1555  2.83
LINK        CA    CA C 303                 O   HOH C 466     1555   1555  3.08
LINK        CA    CA C 303                 O   HOH C 475     1555   1555  2.62
LINK        CA    CA C 303                 O   HOH C 479     1555   1555  2.57
LINK         OD1 ASN E  33                CA    CA E 302     1555   1555  3.12
LINK         O   GLU E  45                CA    CA E 302     1555   1555  2.82
LINK         O   ALA E  47                CA    CA E 302     1555   1555  2.97
LINK         O   GLU D  45                CA    CA D 302     1555   1555  2.90
LINK         O   ALA D  47                CA    CA D 302     1555   1555  2.65
LINK        CA    CA D 302                 O   HOH D 426     1555   1555  2.80
LINK         O   GLU F  45                CA    CA F 302     1555   1555  2.34
LINK         O   ALA F  47                CA    CA F 302     1555   1555  2.69
LINK        CA    CA F 302                 O   HOH F 417     1555   1555  2.45
CISPEP   1 LEU A  206    PRO A  207          0        -8.35
CISPEP   2 SER A  217    PRO A  218          0         0.54
CISPEP   3 LEU B  206    PRO B  207          0       -10.76
CISPEP   4 SER B  217    PRO B  218          0         2.23
CISPEP   5 LEU C  206    PRO C  207          0       -10.86
CISPEP   6 SER C  217    PRO C  218          0        -2.13
CISPEP   7 LEU E  206    PRO E  207          0       -13.03
CISPEP   8 SER E  217    PRO E  218          0         0.13
CISPEP   9 LEU D  206    PRO D  207          0       -13.99
CISPEP  10 SER D  217    PRO D  218          0        -1.72
CISPEP  11 LEU F  206    PRO F  207          0        -8.93
CISPEP  12 SER F  217    PRO F  218          0         0.71
CRYST1   78.185   91.366  124.316  90.00  94.70  90.00 P 1 21 1     12
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.012790  0.000000  0.001053        0.00000
SCALE2      0.000000  0.010945  0.000000        0.00000
SCALE3      0.000000  0.000000  0.008071        0.00000
TER    4098      LEU A 269
TER    8205      LEU B 269
TER   12346      LEU C 269
TER   16439      LEU E 269
TER   20555      LEU D 269
TER   24686      LEU F 269
MASTER      600    0   31   67   60    0    0    613283    6  586  138
END