longtext: 6zth-pdb

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HEADER    HYDROLASE                               20-JUL-20   6ZTH
TITLE     PHOSPHOLIPASE PLAB FROM LEGIONELLA PNEUMOPHILA
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: PLAB PHOSPHOLIPASE;
COMPND   3 CHAIN: A, B, C, D;
COMPND   4 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: LEGIONELLA PNEUMOPHILA;
SOURCE   3 ORGANISM_TAXID: 446;
SOURCE   4 GENE: PLAB, NCTC12000_01733;
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 562
KEYWDS    PHOSPHOLIPASE, ALPHA/BETA HYDROLASE, VIRULENCE, INFECTIOUS DISEASE,
KEYWDS   2 HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    M.G.DIWO,A.FLIEGER,W.BLANKENFELDT
REVDAT   1   02-JUN-21 6ZTH    0
JRNL        AUTH   M.DIWO,W.MICHEL,P.AURASS,K.KUHLE-KEINDORF,J.PIPPEL,
JRNL        AUTH 2 J.KRAUSZE,S.WAMP,C.LANG,W.BLANKENFELDT,A.FLIEGER
JRNL        TITL   NAD(H)-MEDIATED TETRAMERIZATION CONTROLS THE ACTIVITY OF
JRNL        TITL 2 LEGIONELLA PNEUMOPHILA PHOSPHOLIPASE PLAB
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   1
REMARK   1 REFERENCE 1
REMARK   1  AUTH   M.DIWO,W.MICHEL,P.AURASS,K.KUHLE-KEINDORF,J.PIPPEL,
REMARK   1  AUTH 2 J.KRAUSZE,C.LANG,W.BLANKENFELDT,A.FLIEGER
REMARK   1  TITL   NAD(H)-MEDIATED TETRAMERIZATION CONTROLS THE ACTIVITY OF
REMARK   1  TITL 2 LEGIONELLA PNEUMOPHILA PHOSPHOLIPASE PLAB
REMARK   1  REF    BIORXIV                                    2020
REMARK   1  REFN
REMARK   1  DOI    10.1101/2020.09.01.246603
REMARK   2
REMARK   2 RESOLUTION.    2.30 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX DEV_3922
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : ML
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.30
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 49.24
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.340
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.7
REMARK   3   NUMBER OF REFLECTIONS             : 104627
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.366
REMARK   3   R VALUE            (WORKING SET) : 0.364
REMARK   3   FREE R VALUE                     : 0.413
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.010
REMARK   3   FREE R VALUE TEST SET COUNT      : 5247
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 49.2400 -  7.1400    0.98     3337   177  0.4016 0.4210
REMARK   3     2  7.1400 -  5.6700    1.00     3335   175  0.3900 0.3637
REMARK   3     3  5.6700 -  4.9500    1.00     3319   175  0.3546 0.3833
REMARK   3     4  4.9500 -  4.5000    1.00     3320   174  0.3466 0.4029
REMARK   3     5  4.5000 -  4.1800    1.00     3359   177  0.3305 0.4122
REMARK   3     6  4.1800 -  3.9300    1.00     3325   175  0.3377 0.3824
REMARK   3     7  3.9300 -  3.7400    1.00     3280   172  0.3471 0.3676
REMARK   3     8  3.7400 -  3.5700    1.00     3331   177  0.3439 0.4015
REMARK   3     9  3.5700 -  3.4400    1.00     3308   173  0.3472 0.3969
REMARK   3    10  3.4400 -  3.3200    1.00     3324   175  0.3585 0.4069
REMARK   3    11  3.3200 -  3.2100    1.00     3333   175  0.3570 0.4423
REMARK   3    12  3.2100 -  3.1200    1.00     3290   174  0.3624 0.4078
REMARK   3    13  3.1200 -  3.0400    1.00     3322   174  0.3627 0.4271
REMARK   3    14  3.0400 -  2.9700    1.00     3346   176  0.3783 0.4288
REMARK   3    15  2.9700 -  2.9000    1.00     3302   174  0.3688 0.4514
REMARK   3    16  2.9000 -  2.8400    0.99     3287   172  0.3714 0.4728
REMARK   3    17  2.8400 -  2.7800    1.00     3311   176  0.3685 0.4294
REMARK   3    18  2.7800 -  2.7300    1.00     3302   173  0.3907 0.5117
REMARK   3    19  2.7300 -  2.6800    1.00     3296   174  0.3748 0.4236
REMARK   3    20  2.6800 -  2.6300    1.00     3326   175  0.3760 0.4462
REMARK   3    21  2.6300 -  2.5900    1.00     3308   173  0.3835 0.4377
REMARK   3    22  2.5900 -  2.5500    1.00     3329   177  0.3759 0.4072
REMARK   3    23  2.5500 -  2.5100    1.00     3290   173  0.3698 0.4724
REMARK   3    24  2.5100 -  2.4800    1.00     3335   170  0.3787 0.4149
REMARK   3    25  2.4800 -  2.4400    1.00     3281   166  0.3817 0.4139
REMARK   3    26  2.4400 -  2.4100    1.00     3337   186  0.3776 0.3694
REMARK   3    27  2.4100 -  2.3800    1.00     3280   177  0.3824 0.4382
REMARK   3    28  2.3800 -  2.3500    1.00     3308   182  0.3819 0.3837
REMARK   3    29  2.3500 -  2.3300    1.00     3290   187  0.3837 0.4302
REMARK   3    30  2.3300 -  2.3000    1.00     3269   163  0.3851 0.4089
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL
REMARK   3   SOLVENT RADIUS     : 1.11
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.440
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 46.260
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 40.26
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :   NULL           NULL
REMARK   3   ANGLE     :   NULL           NULL
REMARK   3   CHIRALITY :   NULL           NULL
REMARK   3   PLANARITY :   NULL           NULL
REMARK   3   DIHEDRAL  :   NULL           NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : 17
REMARK   3   TLS GROUP : 1
REMARK   3    SELECTION: CHAIN 'D' AND (RESID 335 THROUGH 389 )
REMARK   3    ORIGIN FOR THE GROUP (A): -37.1292  -9.8213 -14.8392
REMARK   3    T TENSOR
REMARK   3      T11:   0.5424 T22:   0.5112
REMARK   3      T33:   0.3257 T12:   0.2414
REMARK   3      T13:  -0.0564 T23:  -0.0499
REMARK   3    L TENSOR
REMARK   3      L11:   0.5883 L22:   0.7370
REMARK   3      L33:   2.2642 L12:   0.3378
REMARK   3      L13:   0.1205 L23:  -0.2868
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0387 S12:   0.4011 S13:  -0.1686
REMARK   3      S21:  -0.0780 S22:  -0.1438 S23:  -0.2315
REMARK   3      S31:   0.1532 S32:   0.5511 S33:   0.0931
REMARK   3   TLS GROUP : 2
REMARK   3    SELECTION: CHAIN 'D' AND (RESID 390 THROUGH 423 )
REMARK   3    ORIGIN FOR THE GROUP (A): -40.7269   0.9709 -16.8102
REMARK   3    T TENSOR
REMARK   3      T11:   0.2115 T22:   0.4364
REMARK   3      T33:   0.4243 T12:   0.0519
REMARK   3      T13:  -0.0734 T23:  -0.0965
REMARK   3    L TENSOR
REMARK   3      L11:   0.1778 L22:   0.6569
REMARK   3      L33:   3.9450 L12:  -0.2262
REMARK   3      L13:  -0.2742 L23:  -0.6863
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0634 S12:  -0.0956 S13:   0.0767
REMARK   3      S21:  -0.0461 S22:   0.0530 S23:  -0.1572
REMARK   3      S31:  -0.0812 S32:   0.2663 S33:   0.0741
REMARK   3   TLS GROUP : 3
REMARK   3    SELECTION: CHAIN 'D' AND (RESID 424 THROUGH 474 )
REMARK   3    ORIGIN FOR THE GROUP (A): -45.3039   2.4767 -28.5478
REMARK   3    T TENSOR
REMARK   3      T11:   0.3748 T22:   0.4873
REMARK   3      T33:   0.3850 T12:   0.2217
REMARK   3      T13:   0.0335 T23:  -0.1046
REMARK   3    L TENSOR
REMARK   3      L11:   0.2092 L22:   0.6646
REMARK   3      L33:   2.2750 L12:   0.2406
REMARK   3      L13:  -0.4666 L23:  -0.7044
REMARK   3    S TENSOR
REMARK   3      S11:   0.0815 S12:   0.0574 S13:  -0.0484
REMARK   3      S21:  -0.0290 S22:  -0.0814 S23:   0.2171
REMARK   3      S31:  -0.0771 S32:  -0.1023 S33:  -0.0669
REMARK   3   TLS GROUP : 4
REMARK   3    SELECTION: CHAIN 'A' AND (RESID -2 THROUGH 74 )
REMARK   3    ORIGIN FOR THE GROUP (A):  -0.8549 -47.0127 -52.2784
REMARK   3    T TENSOR
REMARK   3      T11:   0.3744 T22:   0.3844
REMARK   3      T33:   0.4758 T12:   0.2173
REMARK   3      T13:  -0.0893 T23:  -0.1438
REMARK   3    L TENSOR
REMARK   3      L11:   0.7856 L22:   1.0477
REMARK   3      L33:   0.8421 L12:  -0.4816
REMARK   3      L13:  -0.4920 L23:   0.3168
REMARK   3    S TENSOR
REMARK   3      S11:   0.0872 S12:   0.1434 S13:  -0.0073
REMARK   3      S21:  -0.2414 S22:  -0.0946 S23:  -0.1241
REMARK   3      S31:  -0.0639 S32:  -0.0282 S33:   0.0383
REMARK   3   TLS GROUP : 5
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 75 THROUGH 207 )
REMARK   3    ORIGIN FOR THE GROUP (A):  -5.9039 -32.1616 -54.9633
REMARK   3    T TENSOR
REMARK   3      T11:   0.2862 T22:   0.3782
REMARK   3      T33:   0.2921 T12:   0.2195
REMARK   3      T13:   0.0015 T23:  -0.1658
REMARK   3    L TENSOR
REMARK   3      L11:   0.5676 L22:   0.7214
REMARK   3      L33:   0.4412 L12:  -0.0891
REMARK   3      L13:   0.1145 L23:   0.2327
REMARK   3    S TENSOR
REMARK   3      S11:   0.1076 S12:  -0.0162 S13:  -0.0197
REMARK   3      S21:  -0.1249 S22:  -0.0652 S23:   0.0252
REMARK   3      S31:   0.1888 S32:   0.0505 S33:   0.0594
REMARK   3   TLS GROUP : 6
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 208 THROUGH 362 )
REMARK   3    ORIGIN FOR THE GROUP (A):  -5.6429 -24.6911 -65.8591
REMARK   3    T TENSOR
REMARK   3      T11:   0.2410 T22:   0.4675
REMARK   3      T33:   0.2827 T12:   0.2402
REMARK   3      T13:   0.0502 T23:  -0.0977
REMARK   3    L TENSOR
REMARK   3      L11:   0.2929 L22:   0.4771
REMARK   3      L33:   0.1010 L12:  -0.1906
REMARK   3      L13:   0.0920 L23:   0.1751
REMARK   3    S TENSOR
REMARK   3      S11:   0.0521 S12:   0.3897 S13:  -0.1264
REMARK   3      S21:  -0.1450 S22:   0.0905 S23:  -0.0671
REMARK   3      S31:   0.0654 S32:   0.0994 S33:   0.0130
REMARK   3   TLS GROUP : 7
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 363 THROUGH 474 )
REMARK   3    ORIGIN FOR THE GROUP (A):  -7.6028  -2.0987 -53.1113
REMARK   3    T TENSOR
REMARK   3      T11:   0.2058 T22:   0.2962
REMARK   3      T33:   0.3044 T12:   0.1554
REMARK   3      T13:   0.0198 T23:  -0.0690
REMARK   3    L TENSOR
REMARK   3      L11:   0.3557 L22:   1.3012
REMARK   3      L33:   1.8879 L12:   0.0418
REMARK   3      L13:   0.3669 L23:   0.9910
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0757 S12:   0.0158 S13:   0.0821
REMARK   3      S21:  -0.2223 S22:  -0.0894 S23:   0.0133
REMARK   3      S31:  -0.4917 S32:   0.2506 S33:  -0.0366
REMARK   3   TLS GROUP : 8
REMARK   3    SELECTION: CHAIN 'B' AND (RESID 0 THROUGH 121 )
REMARK   3    ORIGIN FOR THE GROUP (A):   0.7845   9.9209 -22.3798
REMARK   3    T TENSOR
REMARK   3      T11:   0.5719 T22:   0.4402
REMARK   3      T33:   0.2923 T12:   0.2617
REMARK   3      T13:  -0.0262 T23:  -0.1895
REMARK   3    L TENSOR
REMARK   3      L11:   0.7669 L22:   0.0502
REMARK   3      L33:   0.4103 L12:   0.1475
REMARK   3      L13:   0.2060 L23:  -0.0639
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0569 S12:   0.1379 S13:   0.2702
REMARK   3      S21:  -0.0570 S22:  -0.0545 S23:   0.1097
REMARK   3      S31:  -0.2405 S32:   0.0341 S33:  -0.4289
REMARK   3   TLS GROUP : 9
REMARK   3    SELECTION: CHAIN 'B' AND (RESID 122 THROUGH 245 )
REMARK   3    ORIGIN FOR THE GROUP (A):  -7.1042  -8.0780 -17.9537
REMARK   3    T TENSOR
REMARK   3      T11:   0.3166 T22:   0.3746
REMARK   3      T33:   0.3181 T12:   0.1268
REMARK   3      T13:   0.0093 T23:  -0.2168
REMARK   3    L TENSOR
REMARK   3      L11:   0.7162 L22:   0.5322
REMARK   3      L33:   0.8602 L12:   0.4512
REMARK   3      L13:  -0.4498 L23:  -0.0194
REMARK   3    S TENSOR
REMARK   3      S11:   0.0577 S12:   0.1848 S13:   0.0765
REMARK   3      S21:   0.1857 S22:   0.0015 S23:  -0.2630
REMARK   3      S31:   0.0100 S32:  -0.2536 S33:   0.0354
REMARK   3   TLS GROUP : 10
REMARK   3    SELECTION: CHAIN 'B' AND (RESID 246 THROUGH 404 )
REMARK   3    ORIGIN FOR THE GROUP (A):  -8.4186 -10.0642  -8.4179
REMARK   3    T TENSOR
REMARK   3      T11:   0.4140 T22:   0.3101
REMARK   3      T33:   0.2520 T12:   0.1708
REMARK   3      T13:  -0.0466 T23:  -0.0865
REMARK   3    L TENSOR
REMARK   3      L11:   0.5577 L22:   0.8992
REMARK   3      L33:   0.8210 L12:   0.5938
REMARK   3      L13:  -0.1162 L23:   0.0601
REMARK   3    S TENSOR
REMARK   3      S11:   0.0026 S12:  -0.1113 S13:   0.0625
REMARK   3      S21:   0.0120 S22:  -0.0847 S23:   0.1057
REMARK   3      S31:  -0.1424 S32:  -0.1116 S33:   0.0055
REMARK   3   TLS GROUP : 11
REMARK   3    SELECTION: CHAIN 'B' AND (RESID 405 THROUGH 474 )
REMARK   3    ORIGIN FOR THE GROUP (A):  -5.4818 -36.8355 -29.1011
REMARK   3    T TENSOR
REMARK   3      T11:   0.4542 T22:   0.4056
REMARK   3      T33:   0.4787 T12:   0.1762
REMARK   3      T13:   0.0343 T23:  -0.0767
REMARK   3    L TENSOR
REMARK   3      L11:   0.4656 L22:   0.4554
REMARK   3      L33:   2.1982 L12:  -0.1453
REMARK   3      L13:  -0.1389 L23:   0.8071
REMARK   3    S TENSOR
REMARK   3      S11:  -0.1031 S12:   0.0616 S13:  -0.0889
REMARK   3      S21:   0.0739 S22:  -0.1075 S23:   0.0287
REMARK   3      S31:  -0.0310 S32:  -0.0531 S33:   0.1160
REMARK   3   TLS GROUP : 12
REMARK   3    SELECTION: CHAIN 'C' AND (RESID 0 THROUGH 98 )
REMARK   3    ORIGIN FOR THE GROUP (A): -48.6378  11.8602 -52.1045
REMARK   3    T TENSOR
REMARK   3      T11:   0.3188 T22:   0.5000
REMARK   3      T33:   0.4354 T12:   0.2515
REMARK   3      T13:  -0.0420 T23:  -0.1368
REMARK   3    L TENSOR
REMARK   3      L11:   0.6142 L22:   1.8430
REMARK   3      L33:   1.1903 L12:  -0.1247
REMARK   3      L13:  -0.8351 L23:   0.2510
REMARK   3    S TENSOR
REMARK   3      S11:   0.0143 S12:   0.0844 S13:   0.0022
REMARK   3      S21:  -0.1086 S22:   0.0024 S23:   0.2740
REMARK   3      S31:  -0.4288 S32:  -0.2007 S33:  -0.1355
REMARK   3   TLS GROUP : 13
REMARK   3    SELECTION: CHAIN 'C' AND (RESID 99 THROUGH 324 )
REMARK   3    ORIGIN FOR THE GROUP (A): -42.7709  -2.4409 -62.2871
REMARK   3    T TENSOR
REMARK   3      T11:   0.3125 T22:   0.3678
REMARK   3      T33:   0.2560 T12:   0.1537
REMARK   3      T13:  -0.0068 T23:  -0.0707
REMARK   3    L TENSOR
REMARK   3      L11:   0.7469 L22:   1.4226
REMARK   3      L33:   0.2691 L12:   0.2761
REMARK   3      L13:   0.1248 L23:  -0.2471
REMARK   3    S TENSOR
REMARK   3      S11:   0.0401 S12:   0.2646 S13:   0.1044
REMARK   3      S21:  -0.0594 S22:   0.0001 S23:   0.0851
REMARK   3      S31:  -0.0569 S32:  -0.1777 S33:  -0.0562
REMARK   3   TLS GROUP : 14
REMARK   3    SELECTION: CHAIN 'C' AND (RESID 325 THROUGH 474 )
REMARK   3    ORIGIN FOR THE GROUP (A): -40.8021 -29.6869 -54.0568
REMARK   3    T TENSOR
REMARK   3      T11:   0.2195 T22:   0.3832
REMARK   3      T33:   0.3551 T12:   0.1502
REMARK   3      T13:  -0.0238 T23:  -0.0872
REMARK   3    L TENSOR
REMARK   3      L11:   0.1870 L22:   0.3354
REMARK   3      L33:   1.1197 L12:   0.0434
REMARK   3      L13:   0.0110 L23:  -0.3683
REMARK   3    S TENSOR
REMARK   3      S11:   0.0247 S12:   0.0724 S13:   0.0029
REMARK   3      S21:  -0.0237 S22:   0.0089 S23:  -0.0390
REMARK   3      S31:   0.3517 S32:  -0.2015 S33:   0.0232
REMARK   3   TLS GROUP : 15
REMARK   3    SELECTION: CHAIN 'D' AND (RESID -2 THROUGH 113 )
REMARK   3    ORIGIN FOR THE GROUP (A): -50.0857 -43.6752 -22.6434
REMARK   3    T TENSOR
REMARK   3      T11:   0.5042 T22:   0.5345
REMARK   3      T33:   0.3694 T12:   0.2063
REMARK   3      T13:  -0.0138 T23:  -0.1377
REMARK   3    L TENSOR
REMARK   3      L11:   1.7205 L22:   1.8153
REMARK   3      L33:   2.0106 L12:   0.0568
REMARK   3      L13:  -0.8836 L23:  -0.2571
REMARK   3    S TENSOR
REMARK   3      S11:  -0.1372 S12:   0.2158 S13:  -0.2468
REMARK   3      S21:   0.0807 S22:   0.0018 S23:   0.0541
REMARK   3      S31:   0.4144 S32:  -0.1456 S33:   0.1645
REMARK   3   TLS GROUP : 16
REMARK   3    SELECTION: CHAIN 'D' AND (RESID 114 THROUGH 207 )
REMARK   3    ORIGIN FOR THE GROUP (A): -37.8845 -30.0307 -18.5353
REMARK   3    T TENSOR
REMARK   3      T11:   0.3048 T22:   0.3588
REMARK   3      T33:   0.3762 T12:   0.2021
REMARK   3      T13:  -0.0777 T23:  -0.1084
REMARK   3    L TENSOR
REMARK   3      L11:   0.5962 L22:   0.3578
REMARK   3      L33:   0.5260 L12:   0.4260
REMARK   3      L13:   0.0519 L23:   0.1807
REMARK   3    S TENSOR
REMARK   3      S11:   0.1090 S12:   0.1449 S13:  -0.1439
REMARK   3      S21:  -0.3081 S22:  -0.0331 S23:   0.0517
REMARK   3      S31:  -0.1255 S32:   0.1233 S33:   0.0336
REMARK   3   TLS GROUP : 17
REMARK   3    SELECTION: CHAIN 'D' AND (RESID 208 THROUGH 334 )
REMARK   3    ORIGIN FOR THE GROUP (A): -44.2947 -28.9097  -7.7664
REMARK   3    T TENSOR
REMARK   3      T11:   0.4032 T22:   0.2872
REMARK   3      T33:   0.2511 T12:   0.1368
REMARK   3      T13:   0.0220 T23:  -0.0251
REMARK   3    L TENSOR
REMARK   3      L11:   0.6486 L22:   0.6964
REMARK   3      L33:   0.9529 L12:   0.3769
REMARK   3      L13:   0.1510 L23:   0.0347
REMARK   3    S TENSOR
REMARK   3      S11:   0.1304 S12:   0.0583 S13:  -0.0529
REMARK   3      S21:   0.0269 S22:  -0.1051 S23:   0.0196
REMARK   3      S31:   0.1815 S32:   0.0487 S33:  -0.0169
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 6ZTH COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 20-JUL-20.
REMARK 100 THE DEPOSITION ID IS D_1292110174.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 12-SEP-17
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : NULL
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : PETRA III, DESY
REMARK 200  BEAMLINE                       : P11
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9795
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : PIXEL
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS PILATUS 6M-F
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200  DATA SCALING SOFTWARE          : AIMLESS 0.7.4
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 104870
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.300
REMARK 200  RESOLUTION RANGE LOW       (A) : 49.240
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.9
REMARK 200  DATA REDUNDANCY                : 6.900
REMARK 200  R MERGE                    (I) : 0.24300
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 5.9000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.30
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.34
REMARK 200  COMPLETENESS FOR SHELL     (%) : 99.9
REMARK 200  DATA REDUNDANCY IN SHELL       : 6.90
REMARK 200  R MERGE FOR SHELL          (I) : 1.24600
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: SAD
REMARK 200 SOFTWARE USED: PHENIX
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 54.86
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.72
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 77.8 MM NASCN, 1.67% GLYCEROL, 5.44%
REMARK 280  PEG400, 11.6% 2-PROPANOL, 4.11% TACSIMATE , SEEDING REQUIRED,
REMARK 280  VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 292K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000       85.28900
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TETRAMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 25800 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 67910 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -74.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MSE A   -14
REMARK 465     ALA A   -13
REMARK 465     SER A   -12
REMARK 465     TRP A   -11
REMARK 465     SER A   -10
REMARK 465     HIS A    -9
REMARK 465     PRO A    -8
REMARK 465     GLN A    -7
REMARK 465     PHE A    -6
REMARK 465     GLU A    -5
REMARK 465     LYS A    -4
REMARK 465     GLY A    -3
REMARK 465     ASP A   225
REMARK 465     ASN A   226
REMARK 465     GLY A   227
REMARK 465     ALA A   426
REMARK 465     ASP A   427
REMARK 465     ILE A   428
REMARK 465     HIS A   429
REMARK 465     MSE B   -14
REMARK 465     ALA B   -13
REMARK 465     SER B   -12
REMARK 465     TRP B   -11
REMARK 465     SER B   -10
REMARK 465     HIS B    -9
REMARK 465     PRO B    -8
REMARK 465     GLN B    -7
REMARK 465     PHE B    -6
REMARK 465     GLU B    -5
REMARK 465     LYS B    -4
REMARK 465     GLY B    -3
REMARK 465     ALA B    -2
REMARK 465     GLY B    -1
REMARK 465     LEU B   425
REMARK 465     ALA B   426
REMARK 465     ASP B   427
REMARK 465     ILE B   428
REMARK 465     HIS B   429
REMARK 465     MSE C   -14
REMARK 465     ALA C   -13
REMARK 465     SER C   -12
REMARK 465     TRP C   -11
REMARK 465     SER C   -10
REMARK 465     HIS C    -9
REMARK 465     PRO C    -8
REMARK 465     GLN C    -7
REMARK 465     PHE C    -6
REMARK 465     GLU C    -5
REMARK 465     LYS C    -4
REMARK 465     GLY C    -3
REMARK 465     ALA C    -2
REMARK 465     GLY C    -1
REMARK 465     ASP C   225
REMARK 465     ASN C   226
REMARK 465     LEU C   358
REMARK 465     LEU C   425
REMARK 465     ALA C   426
REMARK 465     ASP C   427
REMARK 465     ILE C   428
REMARK 465     HIS C   429
REMARK 465     MSE D   -14
REMARK 465     ALA D   -13
REMARK 465     SER D   -12
REMARK 465     TRP D   -11
REMARK 465     SER D   -10
REMARK 465     HIS D    -9
REMARK 465     PRO D    -8
REMARK 465     GLN D    -7
REMARK 465     PHE D    -6
REMARK 465     GLU D    -5
REMARK 465     LYS D    -4
REMARK 465     GLY D    -3
REMARK 465     ASN D   226
REMARK 465     GLY D   227
REMARK 465     GLU D   228
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     THR A   0    OG1  CG2
REMARK 470     ILE A 141    CG1  CG2  CD1
REMARK 470     VAL A 179    CG1  CG2
REMARK 470     LEU A 180    CG   CD1  CD2
REMARK 470     LEU A 230    CG   CD1  CD2
REMARK 470     LEU A 277    CG   CD1  CD2
REMARK 470     LEU A 425    CG   CD1  CD2
REMARK 470     THR B   0    OG1  CG2
REMARK 470     PHE B 138    CG   CD1  CD2  CE1  CE2  CZ
REMARK 470     GLU B 139    CG   CD   OE1  OE2
REMARK 470     PHE B 310    CG   CD1  CD2  CE1  CE2  CZ
REMARK 470     LEU B 314    CG   CD1  CD2
REMARK 470     LEU B 332    CG   CD1  CD2
REMARK 470     THR C   0    OG1  CG2
REMARK 470     PHE C 137    CG   CD1  CD2  CE1  CE2  CZ
REMARK 470     GLU C 139    CG   CD   OE1  OE2
REMARK 470     GLU C 355    CG   CD   OE1  OE2
REMARK 470     LYS C 403    CG   CD   CE   NZ
REMARK 470     THR D   0    OG1  CG2
REMARK 470     ASP D  71    CG   OD1  OD2
REMARK 470     ILE D 134    CG1  CG2  CD1
REMARK 470     PHE D 137    CG   CD1  CD2  CE1  CE2  CZ
REMARK 470     ILE D 141    CG1  CG2  CD1
REMARK 470     LYS D 312    CG   CD   CE   NZ
REMARK 470     LYS D 393    CG   CD   CE   NZ
REMARK 470     HIS D 429    CG   ND1  CD2  CE1  NE2
REMARK 470     LYS D 467    CG   CD   CE   NZ
REMARK 480
REMARK 480 ZERO OCCUPANCY ATOM
REMARK 480 THE FOLLOWING RESIDUES HAVE ATOMS MODELED WITH ZERO
REMARK 480 OCCUPANCY. THE LOCATION AND PROPERTIES OF THESE ATOMS
REMARK 480 MAY NOT BE RELIABLE. (M=MODEL NUMBER; RES=RESIDUE NAME;
REMARK 480 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):
REMARK 480   M RES C SSEQI ATOMS
REMARK 480     MSE D  394   N
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   HG   SER D   424    HD12  ILE D   431              1.29
REMARK 500   OE2  GLU D   199     HE   ARG D   207              1.46
REMARK 500  HH11  ARG D   368     O    ARG D   373              1.52
REMARK 500   HZ2  LYS B   375     O    HOH B   706              1.58
REMARK 500   HD1  HIS C   433     O    HOH C   614              1.59
REMARK 500   OE2  GLU A   142     O    HOH A   601              1.94
REMARK 500   OE1  GLN B   183     O    HOH B   701              1.96
REMARK 500   NE2  GLN B   352     O    HOH B   702              1.98
REMARK 500   OD2  ASP D   286     O    HOH D   601              1.99
REMARK 500   O    GLN C   188     O    HOH C   601              2.01
REMARK 500   OD1  ASN B   297     NZ   LYS B   300              2.03
REMARK 500   OD1  ASP D   474     O    HOH D   602              2.04
REMARK 500   O    THR D   197     O    HOH D   603              2.04
REMARK 500   O    ILE B   431     O    HOH B   703              2.05
REMARK 500   O    TYR B   196     O    HOH B   704              2.05
REMARK 500   OD2  ASP B   383     O    HOH B   705              2.06
REMARK 500   O    HOH C   726     O    HOH C   732              2.06
REMARK 500   O    GLN B   281     NZ   LYS B   283              2.06
REMARK 500   OG   SER D   129     O    HOH D   604              2.08
REMARK 500   O    HOH B   739     O    HOH B   772              2.09
REMARK 500   O    LYS D   100     O    HOH D   605              2.09
REMARK 500   O    THR A   437     O    HOH A   602              2.11
REMARK 500   OD2  ASP A    62     NH1  ARG A    66              2.11
REMARK 500   OG   SER D   129     O    HOH D   606              2.12
REMARK 500   O    HOH B   727     O    HOH B   793              2.12
REMARK 500   OD1  ASN A   338     O    HOH A   603              2.13
REMARK 500   O    GLN C   395     O    HOH C   602              2.13
REMARK 500   O    ALA A   124     O    HOH A   604              2.14
REMARK 500   O    VAL B   208     OG1  THR B   211              2.14
REMARK 500   OD1  ASN D   162     O    HOH D   607              2.15
REMARK 500   OG   SER D    47     O    HOH D   608              2.15
REMARK 500   O    ASP D   420     O    HOH D   609              2.15
REMARK 500   OD1  ASP A   410     O    HOH A   605              2.15
REMARK 500   O    HOH B   802     O    HOH B   804              2.15
REMARK 500   OE1  GLN A   411     O    HOH A   605              2.15
REMARK 500   O    HOH D   609     O    HOH D   677              2.16
REMARK 500   NZ   LYS B   375     O    HOH B   706              2.16
REMARK 500   NZ   LYS D   472     O    HOH D   602              2.16
REMARK 500   OE2  GLU D   407     O    HOH D   610              2.16
REMARK 500   NZ   LYS C   145     O    HOH C   603              2.17
REMARK 500   OE2  GLU A   294     O    HOH A   606              2.17
REMARK 500   O    MSE C   213     O    HOH C   604              2.17
REMARK 500   OE1  GLU B   436     O    HOH B   707              2.18
REMARK 500   NH1  ARG B   401     O    HOH B   708              2.19
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS
REMARK 500
REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC
REMARK 500 SYMMETRY ARE IN CLOSE CONTACT.  AN ATOM LOCATED WITHIN 0.15
REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A
REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375
REMARK 500 INSTEAD OF REMARK 500.  ATOMS WITH NON-BLANK ALTERNATE
REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS.
REMARK 500
REMARK 500 DISTANCE CUTOFF:
REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS
REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI  SSYMOP   DISTANCE
REMARK 500   O    HOH B   790     O    HOH D   652     1655     2.15
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION
REMARK 500    SER D 424   CB    SER D 424   OG     -0.312
REMARK 500    ILE D 431   CG1   ILE D 431   CD1    -0.595
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    ILE D 431   CB  -  CG1 -  CD1 ANGL. DEV. =  18.3 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    THR A   0      161.27    126.16
REMARK 500    ASP A  34       74.76   -108.48
REMARK 500    SER A  85     -128.09     56.41
REMARK 500    PHE A  99       26.72   -151.78
REMARK 500    ASN A 102       60.04   -150.32
REMARK 500    ALA A 115       61.21     39.67
REMARK 500    ALA A 117       60.80    -69.33
REMARK 500    ASP A 169       73.60   -158.57
REMARK 500    VAL A 205      -57.01   -134.64
REMARK 500    ILE A 256       21.82   -145.09
REMARK 500    LYS A 283       24.60   -141.76
REMARK 500    ASN A 323     -153.04   -100.65
REMARK 500    PRO A 351      -73.74    -36.27
REMARK 500    TYR A 353       79.85     65.00
REMARK 500    ALA A 412     -106.99    -23.05
REMARK 500    LEU A 413      -56.34     63.50
REMARK 500    SER A 424      171.32     94.56
REMARK 500    ASP B  34       66.59   -105.32
REMARK 500    ILE B  69       30.52   -145.53
REMARK 500    ARG B  78      145.24     66.78
REMARK 500    SER B  85     -126.46     59.83
REMARK 500    PHE B  99       31.19   -152.19
REMARK 500    PHE B 137      -60.70   -123.43
REMARK 500    PHE B 138      125.81     68.05
REMARK 500    GLU B 139      -25.28    149.87
REMARK 500    GLU B 142      -85.90    -97.16
REMARK 500    VAL B 205      -65.65   -142.51
REMARK 500    ASP B 225     -132.72     53.10
REMARK 500    ASN B 226       38.32    -90.16
REMARK 500    SER B 229      -62.17    161.29
REMARK 500    LEU B 230     -108.51     81.12
REMARK 500    ILE B 256       25.64   -141.02
REMARK 500    LYS B 283       23.22   -143.24
REMARK 500    LEU B 314       -8.40    -59.48
REMARK 500    ASP B 335        5.87    -68.22
REMARK 500    ASN C  15       -8.15    -56.38
REMARK 500    ASP C  34       57.05   -104.68
REMARK 500    ARG C  78      146.23     63.12
REMARK 500    SER C  85     -133.12     59.56
REMARK 500    PHE C  99       34.54   -142.79
REMARK 500    ASN C 102       82.16   -155.24
REMARK 500    PHE C 138      132.45    -12.77
REMARK 500    GLU C 139      -36.65   -167.86
REMARK 500    ILE C 141      111.08     66.17
REMARK 500    GLU C 142      -68.10   -135.99
REMARK 500    ASP C 169       76.03   -161.21
REMARK 500    VAL C 205      -48.85   -137.37
REMARK 500    GLU C 228     -135.42   -140.53
REMARK 500    SER C 229      -70.89     79.59
REMARK 500    LEU C 230     -129.27     76.95
REMARK 500
REMARK 500 THIS ENTRY HAS      75 RAMACHANDRAN OUTLIERS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS
REMARK 500
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.
REMARK 500                                 MODEL     OMEGA
REMARK 500 SER A  423     SER A  424                  149.20
REMARK 500 LEU C  230     VAL C  231                 -149.92
REMARK 500 SER D  424     LEU D  425                 -148.27
REMARK 500
REMARK 500 REMARK: NULL
REMARK 525
REMARK 525 SOLVENT
REMARK 525
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 525 NUMBER; I=INSERTION CODE):
REMARK 525
REMARK 525  M RES CSSEQI
REMARK 525    HOH A 730        DISTANCE =  6.09 ANGSTROMS
REMARK 525    HOH A 731        DISTANCE =  6.29 ANGSTROMS
REMARK 525    HOH B 817        DISTANCE =  6.04 ANGSTROMS
REMARK 525    HOH B 818        DISTANCE =  6.61 ANGSTROMS
REMARK 525    HOH B 819        DISTANCE =  6.70 ANGSTROMS
REMARK 525    HOH B 820        DISTANCE =  7.00 ANGSTROMS
REMARK 525    HOH B 821        DISTANCE =  7.56 ANGSTROMS
REMARK 525    HOH B 822        DISTANCE =  7.59 ANGSTROMS
REMARK 525    HOH B 823        DISTANCE =  8.36 ANGSTROMS
REMARK 525    HOH B 824        DISTANCE =  8.51 ANGSTROMS
REMARK 525    HOH B 825        DISTANCE =  9.10 ANGSTROMS
REMARK 525    HOH C 734        DISTANCE =  5.81 ANGSTROMS
REMARK 525    HOH C 735        DISTANCE =  5.91 ANGSTROMS
REMARK 525    HOH C 736        DISTANCE =  5.96 ANGSTROMS
REMARK 525    HOH C 737        DISTANCE =  6.28 ANGSTROMS
REMARK 525    HOH C 738        DISTANCE =  6.46 ANGSTROMS
REMARK 525    HOH C 739        DISTANCE =  6.66 ANGSTROMS
REMARK 525    HOH C 740        DISTANCE =  6.70 ANGSTROMS
REMARK 525    HOH C 741        DISTANCE =  6.88 ANGSTROMS
REMARK 525    HOH C 742        DISTANCE =  6.99 ANGSTROMS
REMARK 525    HOH C 743        DISTANCE =  7.49 ANGSTROMS
REMARK 525    HOH C 744        DISTANCE =  7.93 ANGSTROMS
REMARK 525    HOH C 745        DISTANCE =  8.12 ANGSTROMS
REMARK 525    HOH C 746        DISTANCE =  8.53 ANGSTROMS
REMARK 525    HOH C 747        DISTANCE =  9.81 ANGSTROMS
REMARK 525    HOH C 748        DISTANCE = 10.11 ANGSTROMS
REMARK 525    HOH D 732        DISTANCE =  6.12 ANGSTROMS
REMARK 525    HOH D 733        DISTANCE =  6.13 ANGSTROMS
REMARK 525    HOH D 734        DISTANCE =  6.26 ANGSTROMS
REMARK 525    HOH D 735        DISTANCE =  6.30 ANGSTROMS
REMARK 525    HOH D 736        DISTANCE =  6.34 ANGSTROMS
REMARK 525    HOH D 737        DISTANCE =  6.41 ANGSTROMS
REMARK 525    HOH D 738        DISTANCE =  8.59 ANGSTROMS
REMARK 525    HOH D 739        DISTANCE = 10.09 ANGSTROMS
DBREF1 6ZTH A    1   474  UNP                  A0A378K488_LEGPN
DBREF2 6ZTH A     A0A378K488                          1         474
DBREF1 6ZTH B    1   474  UNP                  A0A378K488_LEGPN
DBREF2 6ZTH B     A0A378K488                          1         474
DBREF1 6ZTH C    1   474  UNP                  A0A378K488_LEGPN
DBREF2 6ZTH C     A0A378K488                          1         474
DBREF1 6ZTH D    1   474  UNP                  A0A378K488_LEGPN
DBREF2 6ZTH D     A0A378K488                          1         474
SEQADV 6ZTH MSE A  -14  UNP  A0A378K48           INITIATING METHIONINE
SEQADV 6ZTH ALA A  -13  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH SER A  -12  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH TRP A  -11  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH SER A  -10  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH HIS A   -9  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH PRO A   -8  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH GLN A   -7  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH PHE A   -6  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH GLU A   -5  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH LYS A   -4  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH GLY A   -3  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH ALA A   -2  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH GLY A   -1  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH THR A    0  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH ASN A  203  UNP  A0A378K48 ASP   203 CONFLICT
SEQADV 6ZTH MSE B  -14  UNP  A0A378K48           INITIATING METHIONINE
SEQADV 6ZTH ALA B  -13  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH SER B  -12  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH TRP B  -11  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH SER B  -10  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH HIS B   -9  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH PRO B   -8  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH GLN B   -7  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH PHE B   -6  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH GLU B   -5  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH LYS B   -4  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH GLY B   -3  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH ALA B   -2  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH GLY B   -1  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH THR B    0  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH ASN B  203  UNP  A0A378K48 ASP   203 CONFLICT
SEQADV 6ZTH MSE C  -14  UNP  A0A378K48           INITIATING METHIONINE
SEQADV 6ZTH ALA C  -13  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH SER C  -12  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH TRP C  -11  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH SER C  -10  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH HIS C   -9  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH PRO C   -8  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH GLN C   -7  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH PHE C   -6  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH GLU C   -5  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH LYS C   -4  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH GLY C   -3  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH ALA C   -2  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH GLY C   -1  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH THR C    0  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH ASN C  203  UNP  A0A378K48 ASP   203 CONFLICT
SEQADV 6ZTH MSE D  -14  UNP  A0A378K48           INITIATING METHIONINE
SEQADV 6ZTH ALA D  -13  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH SER D  -12  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH TRP D  -11  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH SER D  -10  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH HIS D   -9  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH PRO D   -8  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH GLN D   -7  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH PHE D   -6  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH GLU D   -5  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH LYS D   -4  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH GLY D   -3  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH ALA D   -2  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH GLY D   -1  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH THR D    0  UNP  A0A378K48           EXPRESSION TAG
SEQADV 6ZTH ASN D  203  UNP  A0A378K48 ASP   203 CONFLICT
SEQRES   1 A  489  MSE ALA SER TRP SER HIS PRO GLN PHE GLU LYS GLY ALA
SEQRES   2 A  489  GLY THR MSE ILE VAL ILE PHE VAL HIS GLY TRP SER VAL
SEQRES   3 A  489  THR HIS THR ASN THR TYR GLY GLU LEU PRO GLN TRP LEU
SEQRES   4 A  489  GLU ASN GLN SER LYS GLN GLY LYS LEU ASP ILE GLN VAL
SEQRES   5 A  489  GLY ASN ILE TYR LEU GLY ARG TYR ILE SER PHE ASP ASP
SEQRES   6 A  489  THR VAL THR VAL ASP ASP ILE ALA ARG ALA PHE ASP GLN
SEQRES   7 A  489  ALA VAL ARG ASP GLU ILE ALA ASP LYS LEU ARG ASP GLY
SEQRES   8 A  489  GLN ARG PHE ALA CYS ILE THR HIS SER THR GLY GLY PRO
SEQRES   9 A  489  ILE VAL ARG LYS TRP MSE ASP LEU TYR PHE LYS ASN ASN
SEQRES  10 A  489  LEU ALA LYS CYS PRO LEU SER HIS LEU ILE MSE LEU ALA
SEQRES  11 A  489  PRO ALA ASN HIS GLY SER ALA LEU ALA GLN LEU GLY LYS
SEQRES  12 A  489  SER ARG LEU GLY ARG ILE LYS SER PHE PHE GLU GLY ILE
SEQRES  13 A  489  GLU PRO GLY LYS CYS VAL LEU ASP TRP LEU GLU LEU GLY
SEQRES  14 A  489  SER ASP MSE SER TRP GLN LEU ASN GLU SER TRP LEU ASP
SEQRES  15 A  489  TYR ASP CYS THR ALA ASN GLY VAL TYR SER PHE VAL LEU
SEQRES  16 A  489  THR GLY GLN LYS ILE ASP ARG GLN PHE TYR ASP ALA VAL
SEQRES  17 A  489  ASN SER TYR THR GLY GLU SER GLY SER ASN GLY VAL VAL
SEQRES  18 A  489  ARG VAL ALA ALA THR ASN MSE ASN TYR SER LEU LEU LYS
SEQRES  19 A  489  LEU HIS GLN GLU GLY ASP ASN GLY GLU SER LEU VAL VAL
SEQRES  20 A  489  ALA LYS MSE THR ARG THR GLN PRO MSE ALA PHE GLY VAL
SEQRES  21 A  489  LEU PRO GLY LEU SER HIS SER GLY LYS ASN ILE GLY ILE
SEQRES  22 A  489  ILE ARG SER ILE THR MSE ALA ASN ALA ALA THR HIS PRO
SEQRES  23 A  489  THR ALA ILE TRP ILE LEU ARG CYS LEU GLN VAL LYS SER
SEQRES  24 A  489  ARG ASP SER TYR ASN LYS LEU VAL LYS GLU LEU ASP ASN
SEQRES  25 A  489  ILE THR LYS GLU THR GLN LYS ASN GLU HIS LYS GLU PHE
SEQRES  26 A  489  VAL LYS THR LEU VAL PHE THR ARG GLU TYR ILE THR ASN
SEQRES  27 A  489  ARG TYR SER MSE ILE ILE PHE ARG LEU ILE ASP ASP ARG
SEQRES  28 A  489  GLY ASN HIS LEU ILE ASP TYR ASP LEU TYR LEU THR ALA
SEQRES  29 A  489  GLY PRO GLN TYR SER GLU GLN ALA LEU PRO ALA GLY PHE
SEQRES  30 A  489  PHE VAL ASP ARG GLN ARG ASN LEU ASN ASN ARG GLY LYS
SEQRES  31 A  489  LEU THR TYR PHE LEU ASP TYR ASP ILE MSE GLU GLY GLY
SEQRES  32 A  489  ILE ASN THR PRO LYS MSE GLN GLY ASN LEU GLY PHE ARG
SEQRES  33 A  489  VAL LYS ALA TYR PRO GLU SER SER ASP GLN ALA LEU ALA
SEQRES  34 A  489  TYR TYR ARG LEU LEU ASP PHE HIS SER SER LEU ALA ASP
SEQRES  35 A  489  ILE HIS LYS ILE LEU HIS PRO ASN GLU THR VAL MSE VAL
SEQRES  36 A  489  GLU ILE MSE LEU GLN ARG ARG VAL ASP ARG THR VAL PHE
SEQRES  37 A  489  ARG ILE SER ASN ASN LEU THR PRO ALA LYS ILE SER GLY
SEQRES  38 A  489  LYS PRO THR GLY LYS LYS ILE ASP
SEQRES   1 B  489  MSE ALA SER TRP SER HIS PRO GLN PHE GLU LYS GLY ALA
SEQRES   2 B  489  GLY THR MSE ILE VAL ILE PHE VAL HIS GLY TRP SER VAL
SEQRES   3 B  489  THR HIS THR ASN THR TYR GLY GLU LEU PRO GLN TRP LEU
SEQRES   4 B  489  GLU ASN GLN SER LYS GLN GLY LYS LEU ASP ILE GLN VAL
SEQRES   5 B  489  GLY ASN ILE TYR LEU GLY ARG TYR ILE SER PHE ASP ASP
SEQRES   6 B  489  THR VAL THR VAL ASP ASP ILE ALA ARG ALA PHE ASP GLN
SEQRES   7 B  489  ALA VAL ARG ASP GLU ILE ALA ASP LYS LEU ARG ASP GLY
SEQRES   8 B  489  GLN ARG PHE ALA CYS ILE THR HIS SER THR GLY GLY PRO
SEQRES   9 B  489  ILE VAL ARG LYS TRP MSE ASP LEU TYR PHE LYS ASN ASN
SEQRES  10 B  489  LEU ALA LYS CYS PRO LEU SER HIS LEU ILE MSE LEU ALA
SEQRES  11 B  489  PRO ALA ASN HIS GLY SER ALA LEU ALA GLN LEU GLY LYS
SEQRES  12 B  489  SER ARG LEU GLY ARG ILE LYS SER PHE PHE GLU GLY ILE
SEQRES  13 B  489  GLU PRO GLY LYS CYS VAL LEU ASP TRP LEU GLU LEU GLY
SEQRES  14 B  489  SER ASP MSE SER TRP GLN LEU ASN GLU SER TRP LEU ASP
SEQRES  15 B  489  TYR ASP CYS THR ALA ASN GLY VAL TYR SER PHE VAL LEU
SEQRES  16 B  489  THR GLY GLN LYS ILE ASP ARG GLN PHE TYR ASP ALA VAL
SEQRES  17 B  489  ASN SER TYR THR GLY GLU SER GLY SER ASN GLY VAL VAL
SEQRES  18 B  489  ARG VAL ALA ALA THR ASN MSE ASN TYR SER LEU LEU LYS
SEQRES  19 B  489  LEU HIS GLN GLU GLY ASP ASN GLY GLU SER LEU VAL VAL
SEQRES  20 B  489  ALA LYS MSE THR ARG THR GLN PRO MSE ALA PHE GLY VAL
SEQRES  21 B  489  LEU PRO GLY LEU SER HIS SER GLY LYS ASN ILE GLY ILE
SEQRES  22 B  489  ILE ARG SER ILE THR MSE ALA ASN ALA ALA THR HIS PRO
SEQRES  23 B  489  THR ALA ILE TRP ILE LEU ARG CYS LEU GLN VAL LYS SER
SEQRES  24 B  489  ARG ASP SER TYR ASN LYS LEU VAL LYS GLU LEU ASP ASN
SEQRES  25 B  489  ILE THR LYS GLU THR GLN LYS ASN GLU HIS LYS GLU PHE
SEQRES  26 B  489  VAL LYS THR LEU VAL PHE THR ARG GLU TYR ILE THR ASN
SEQRES  27 B  489  ARG TYR SER MSE ILE ILE PHE ARG LEU ILE ASP ASP ARG
SEQRES  28 B  489  GLY ASN HIS LEU ILE ASP TYR ASP LEU TYR LEU THR ALA
SEQRES  29 B  489  GLY PRO GLN TYR SER GLU GLN ALA LEU PRO ALA GLY PHE
SEQRES  30 B  489  PHE VAL ASP ARG GLN ARG ASN LEU ASN ASN ARG GLY LYS
SEQRES  31 B  489  LEU THR TYR PHE LEU ASP TYR ASP ILE MSE GLU GLY GLY
SEQRES  32 B  489  ILE ASN THR PRO LYS MSE GLN GLY ASN LEU GLY PHE ARG
SEQRES  33 B  489  VAL LYS ALA TYR PRO GLU SER SER ASP GLN ALA LEU ALA
SEQRES  34 B  489  TYR TYR ARG LEU LEU ASP PHE HIS SER SER LEU ALA ASP
SEQRES  35 B  489  ILE HIS LYS ILE LEU HIS PRO ASN GLU THR VAL MSE VAL
SEQRES  36 B  489  GLU ILE MSE LEU GLN ARG ARG VAL ASP ARG THR VAL PHE
SEQRES  37 B  489  ARG ILE SER ASN ASN LEU THR PRO ALA LYS ILE SER GLY
SEQRES  38 B  489  LYS PRO THR GLY LYS LYS ILE ASP
SEQRES   1 C  489  MSE ALA SER TRP SER HIS PRO GLN PHE GLU LYS GLY ALA
SEQRES   2 C  489  GLY THR MSE ILE VAL ILE PHE VAL HIS GLY TRP SER VAL
SEQRES   3 C  489  THR HIS THR ASN THR TYR GLY GLU LEU PRO GLN TRP LEU
SEQRES   4 C  489  GLU ASN GLN SER LYS GLN GLY LYS LEU ASP ILE GLN VAL
SEQRES   5 C  489  GLY ASN ILE TYR LEU GLY ARG TYR ILE SER PHE ASP ASP
SEQRES   6 C  489  THR VAL THR VAL ASP ASP ILE ALA ARG ALA PHE ASP GLN
SEQRES   7 C  489  ALA VAL ARG ASP GLU ILE ALA ASP LYS LEU ARG ASP GLY
SEQRES   8 C  489  GLN ARG PHE ALA CYS ILE THR HIS SER THR GLY GLY PRO
SEQRES   9 C  489  ILE VAL ARG LYS TRP MSE ASP LEU TYR PHE LYS ASN ASN
SEQRES  10 C  489  LEU ALA LYS CYS PRO LEU SER HIS LEU ILE MSE LEU ALA
SEQRES  11 C  489  PRO ALA ASN HIS GLY SER ALA LEU ALA GLN LEU GLY LYS
SEQRES  12 C  489  SER ARG LEU GLY ARG ILE LYS SER PHE PHE GLU GLY ILE
SEQRES  13 C  489  GLU PRO GLY LYS CYS VAL LEU ASP TRP LEU GLU LEU GLY
SEQRES  14 C  489  SER ASP MSE SER TRP GLN LEU ASN GLU SER TRP LEU ASP
SEQRES  15 C  489  TYR ASP CYS THR ALA ASN GLY VAL TYR SER PHE VAL LEU
SEQRES  16 C  489  THR GLY GLN LYS ILE ASP ARG GLN PHE TYR ASP ALA VAL
SEQRES  17 C  489  ASN SER TYR THR GLY GLU SER GLY SER ASN GLY VAL VAL
SEQRES  18 C  489  ARG VAL ALA ALA THR ASN MSE ASN TYR SER LEU LEU LYS
SEQRES  19 C  489  LEU HIS GLN GLU GLY ASP ASN GLY GLU SER LEU VAL VAL
SEQRES  20 C  489  ALA LYS MSE THR ARG THR GLN PRO MSE ALA PHE GLY VAL
SEQRES  21 C  489  LEU PRO GLY LEU SER HIS SER GLY LYS ASN ILE GLY ILE
SEQRES  22 C  489  ILE ARG SER ILE THR MSE ALA ASN ALA ALA THR HIS PRO
SEQRES  23 C  489  THR ALA ILE TRP ILE LEU ARG CYS LEU GLN VAL LYS SER
SEQRES  24 C  489  ARG ASP SER TYR ASN LYS LEU VAL LYS GLU LEU ASP ASN
SEQRES  25 C  489  ILE THR LYS GLU THR GLN LYS ASN GLU HIS LYS GLU PHE
SEQRES  26 C  489  VAL LYS THR LEU VAL PHE THR ARG GLU TYR ILE THR ASN
SEQRES  27 C  489  ARG TYR SER MSE ILE ILE PHE ARG LEU ILE ASP ASP ARG
SEQRES  28 C  489  GLY ASN HIS LEU ILE ASP TYR ASP LEU TYR LEU THR ALA
SEQRES  29 C  489  GLY PRO GLN TYR SER GLU GLN ALA LEU PRO ALA GLY PHE
SEQRES  30 C  489  PHE VAL ASP ARG GLN ARG ASN LEU ASN ASN ARG GLY LYS
SEQRES  31 C  489  LEU THR TYR PHE LEU ASP TYR ASP ILE MSE GLU GLY GLY
SEQRES  32 C  489  ILE ASN THR PRO LYS MSE GLN GLY ASN LEU GLY PHE ARG
SEQRES  33 C  489  VAL LYS ALA TYR PRO GLU SER SER ASP GLN ALA LEU ALA
SEQRES  34 C  489  TYR TYR ARG LEU LEU ASP PHE HIS SER SER LEU ALA ASP
SEQRES  35 C  489  ILE HIS LYS ILE LEU HIS PRO ASN GLU THR VAL MSE VAL
SEQRES  36 C  489  GLU ILE MSE LEU GLN ARG ARG VAL ASP ARG THR VAL PHE
SEQRES  37 C  489  ARG ILE SER ASN ASN LEU THR PRO ALA LYS ILE SER GLY
SEQRES  38 C  489  LYS PRO THR GLY LYS LYS ILE ASP
SEQRES   1 D  489  MSE ALA SER TRP SER HIS PRO GLN PHE GLU LYS GLY ALA
SEQRES   2 D  489  GLY THR MSE ILE VAL ILE PHE VAL HIS GLY TRP SER VAL
SEQRES   3 D  489  THR HIS THR ASN THR TYR GLY GLU LEU PRO GLN TRP LEU
SEQRES   4 D  489  GLU ASN GLN SER LYS GLN GLY LYS LEU ASP ILE GLN VAL
SEQRES   5 D  489  GLY ASN ILE TYR LEU GLY ARG TYR ILE SER PHE ASP ASP
SEQRES   6 D  489  THR VAL THR VAL ASP ASP ILE ALA ARG ALA PHE ASP GLN
SEQRES   7 D  489  ALA VAL ARG ASP GLU ILE ALA ASP LYS LEU ARG ASP GLY
SEQRES   8 D  489  GLN ARG PHE ALA CYS ILE THR HIS SER THR GLY GLY PRO
SEQRES   9 D  489  ILE VAL ARG LYS TRP MSE ASP LEU TYR PHE LYS ASN ASN
SEQRES  10 D  489  LEU ALA LYS CYS PRO LEU SER HIS LEU ILE MSE LEU ALA
SEQRES  11 D  489  PRO ALA ASN HIS GLY SER ALA LEU ALA GLN LEU GLY LYS
SEQRES  12 D  489  SER ARG LEU GLY ARG ILE LYS SER PHE PHE GLU GLY ILE
SEQRES  13 D  489  GLU PRO GLY LYS CYS VAL LEU ASP TRP LEU GLU LEU GLY
SEQRES  14 D  489  SER ASP MSE SER TRP GLN LEU ASN GLU SER TRP LEU ASP
SEQRES  15 D  489  TYR ASP CYS THR ALA ASN GLY VAL TYR SER PHE VAL LEU
SEQRES  16 D  489  THR GLY GLN LYS ILE ASP ARG GLN PHE TYR ASP ALA VAL
SEQRES  17 D  489  ASN SER TYR THR GLY GLU SER GLY SER ASN GLY VAL VAL
SEQRES  18 D  489  ARG VAL ALA ALA THR ASN MSE ASN TYR SER LEU LEU LYS
SEQRES  19 D  489  LEU HIS GLN GLU GLY ASP ASN GLY GLU SER LEU VAL VAL
SEQRES  20 D  489  ALA LYS MSE THR ARG THR GLN PRO MSE ALA PHE GLY VAL
SEQRES  21 D  489  LEU PRO GLY LEU SER HIS SER GLY LYS ASN ILE GLY ILE
SEQRES  22 D  489  ILE ARG SER ILE THR MSE ALA ASN ALA ALA THR HIS PRO
SEQRES  23 D  489  THR ALA ILE TRP ILE LEU ARG CYS LEU GLN VAL LYS SER
SEQRES  24 D  489  ARG ASP SER TYR ASN LYS LEU VAL LYS GLU LEU ASP ASN
SEQRES  25 D  489  ILE THR LYS GLU THR GLN LYS ASN GLU HIS LYS GLU PHE
SEQRES  26 D  489  VAL LYS THR LEU VAL PHE THR ARG GLU TYR ILE THR ASN
SEQRES  27 D  489  ARG TYR SER MSE ILE ILE PHE ARG LEU ILE ASP ASP ARG
SEQRES  28 D  489  GLY ASN HIS LEU ILE ASP TYR ASP LEU TYR LEU THR ALA
SEQRES  29 D  489  GLY PRO GLN TYR SER GLU GLN ALA LEU PRO ALA GLY PHE
SEQRES  30 D  489  PHE VAL ASP ARG GLN ARG ASN LEU ASN ASN ARG GLY LYS
SEQRES  31 D  489  LEU THR TYR PHE LEU ASP TYR ASP ILE MSE GLU GLY GLY
SEQRES  32 D  489  ILE ASN THR PRO LYS MSE GLN GLY ASN LEU GLY PHE ARG
SEQRES  33 D  489  VAL LYS ALA TYR PRO GLU SER SER ASP GLN ALA LEU ALA
SEQRES  34 D  489  TYR TYR ARG LEU LEU ASP PHE HIS SER SER LEU ALA ASP
SEQRES  35 D  489  ILE HIS LYS ILE LEU HIS PRO ASN GLU THR VAL MSE VAL
SEQRES  36 D  489  GLU ILE MSE LEU GLN ARG ARG VAL ASP ARG THR VAL PHE
SEQRES  37 D  489  ARG ILE SER ASN ASN LEU THR PRO ALA LYS ILE SER GLY
SEQRES  38 D  489  LYS PRO THR GLY LYS LYS ILE ASP
MODRES 6ZTH MSE A    1  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE A   95  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE A  113  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE A  157  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE A  213  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE A  235  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE A  241  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE A  264  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE A  327  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE A  385  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE A  394  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE A  439  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE A  443  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE B    1  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE B   95  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE B  113  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE B  157  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE B  213  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE B  235  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE B  241  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE B  264  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE B  327  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE B  385  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE B  394  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE B  439  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE B  443  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE C    1  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE C   95  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE C  113  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE C  157  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE C  213  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE C  235  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE C  241  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE C  264  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE C  327  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE C  385  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE C  394  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE C  439  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE C  443  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE D    1  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE D   95  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE D  113  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE D  157  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE D  213  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE D  235  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE D  241  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE D  264  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE D  327  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE D  385  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE D  394  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE D  439  MET  MODIFIED RESIDUE
MODRES 6ZTH MSE D  443  MET  MODIFIED RESIDUE
HET    MSE  A   1      17
HET    MSE  A  95      17
HET    MSE  A 113      17
HET    MSE  A 157      17
HET    MSE  A 213      17
HET    MSE  A 235      17
HET    MSE  A 241      17
HET    MSE  A 264      17
HET    MSE  A 327      17
HET    MSE  A 385      17
HET    MSE  A 394      17
HET    MSE  A 439      17
HET    MSE  A 443      17
HET    MSE  B   1      17
HET    MSE  B  95      17
HET    MSE  B 113      17
HET    MSE  B 157      17
HET    MSE  B 213      17
HET    MSE  B 235      17
HET    MSE  B 241      17
HET    MSE  B 264      17
HET    MSE  B 327      17
HET    MSE  B 385      17
HET    MSE  B 394      17
HET    MSE  B 439      17
HET    MSE  B 443      17
HET    MSE  C   1      17
HET    MSE  C  95      17
HET    MSE  C 113      17
HET    MSE  C 157      17
HET    MSE  C 213      17
HET    MSE  C 235      17
HET    MSE  C 241      17
HET    MSE  C 264      17
HET    MSE  C 327      17
HET    MSE  C 385      17
HET    MSE  C 394      17
HET    MSE  C 439      17
HET    MSE  C 443      17
HET    MSE  D   1      17
HET    MSE  D  95      17
HET    MSE  D 113      17
HET    MSE  D 157      17
HET    MSE  D 213      17
HET    MSE  D 235      17
HET    MSE  D 241      17
HET    MSE  D 264      17
HET    MSE  D 327      17
HET    MSE  D 385      17
HET    MSE  D 394      17
HET    MSE  D 439      17
HET    MSE  D 443      17
HET    NAD  A 501      70
HET    NAD  A 502      70
HET    NAD  B 601      70
HET    NAD  B 602      70
HET    NAD  C 501      70
HET    NAD  C 502      70
HET    NAD  D 501      70
HET    NAD  D 502      70
HETNAM     MSE SELENOMETHIONINE
HETNAM     NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE
FORMUL   1  MSE    52(C5 H11 N O2 SE)
FORMUL   5  NAD    8(C21 H27 N7 O14 P2)
FORMUL  13  HOH   *543(H2 O)
HELIX    1 AA1 HIS A   13  GLY A   18  5                                   6
HELIX    2 AA2 GLU A   19  GLN A   30  1                                  12
HELIX    3 AA3 THR A   53  ASP A   75  1                                  23
HELIX    4 AA4 THR A   86  LYS A  100  1                                  15
HELIX    5 AA5 ASN A  101  CYS A  106  5                                   6
HELIX    6 AA6 SER A  121  LEU A  126  5                                   6
HELIX    7 AA7 GLY A  127  ARG A  133  1                                   7
HELIX    8 AA8 GLY A  144  GLU A  152  1                                   9
HELIX    9 AA9 SER A  155  TRP A  165  1                                  11
HELIX   10 AB1 LEU A  166  TYR A  168  5                                   3
HELIX   11 AB2 CYS A  170  GLY A  174  5                                   5
HELIX   12 AB3 ASP A  186  TYR A  190  5                                   5
HELIX   13 AB4 ASN A  194  GLU A  199  5                                   6
HELIX   14 AB5 ARG A  207  ASN A  212  1                                   6
HELIX   15 AB6 HIS A  270  GLN A  281  1                                  12
HELIX   16 AB7 SER A  284  GLU A  306  1                                  23
HELIX   17 AB8 TYR A  382  ASN A  390  1                                   9
HELIX   18 AB9 HIS B   13  GLY B   18  5                                   6
HELIX   19 AC1 GLU B   19  LYS B   29  1                                  11
HELIX   20 AC2 THR B   53  GLY B   76  1                                  24
HELIX   21 AC3 THR B   86  LYS B  100  1                                  15
HELIX   22 AC4 ASN B  102  CYS B  106  5                                   5
HELIX   23 AC5 SER B  121  GLY B  127  5                                   7
HELIX   24 AC6 LYS B  128  ARG B  133  1                                   6
HELIX   25 AC7 GLY B  144  GLU B  152  1                                   9
HELIX   26 AC8 SER B  155  TRP B  165  1                                  11
HELIX   27 AC9 LEU B  166  TYR B  168  5                                   3
HELIX   28 AD1 CYS B  170  GLY B  174  5                                   5
HELIX   29 AD2 ASP B  186  TYR B  190  5                                   5
HELIX   30 AD3 ASN B  194  GLU B  199  5                                   6
HELIX   31 AD4 ARG B  207  ASN B  212  1                                   6
HELIX   32 AD5 ASN B  266  THR B  269  5                                   4
HELIX   33 AD6 HIS B  270  GLN B  281  1                                  12
HELIX   34 AD7 SER B  284  GLU B  306  1                                  23
HELIX   35 AD8 TYR B  382  ASN B  390  1                                   9
HELIX   36 AD9 HIS C   13  GLY C   18  5                                   6
HELIX   37 AE1 GLU C   19  GLN C   30  1                                  12
HELIX   38 AE2 THR C   53  ASP C   75  1                                  23
HELIX   39 AE3 THR C   86  PHE C   99  1                                  14
HELIX   40 AE4 ASN C  102  CYS C  106  5                                   5
HELIX   41 AE5 LEU C  123  LEU C  126  5                                   4
HELIX   42 AE6 GLY C  127  ARG C  133  1                                   7
HELIX   43 AE7 GLY C  144  GLU C  152  1                                   9
HELIX   44 AE8 SER C  155  SER C  164  1                                  10
HELIX   45 AE9 TRP C  165  TYR C  168  5                                   4
HELIX   46 AF1 CYS C  170  GLY C  174  5                                   5
HELIX   47 AF2 ASP C  186  TYR C  190  5                                   5
HELIX   48 AF3 ASN C  194  GLU C  199  5                                   6
HELIX   49 AF4 ARG C  207  ASN C  212  1                                   6
HELIX   50 AF5 ASN C  266  THR C  269  5                                   4
HELIX   51 AF6 HIS C  270  VAL C  282  1                                  13
HELIX   52 AF7 SER C  284  GLU C  306  1                                  23
HELIX   53 AF8 TYR C  382  ASN C  390  1                                   9
HELIX   54 AF9 THR C  391  GLN C  395  5                                   5
HELIX   55 AG1 HIS D   13  GLY D   18  5                                   6
HELIX   56 AG2 GLU D   19  GLN D   30  1                                  12
HELIX   57 AG3 THR D   53  ILE D   69  1                                  17
HELIX   58 AG4 ILE D   69  ASP D   75  1                                   7
HELIX   59 AG5 THR D   86  PHE D   99  1                                  14
HELIX   60 AG6 ASN D  102  CYS D  106  5                                   5
HELIX   61 AG7 SER D  121  LEU D  126  1                                   6
HELIX   62 AG8 GLY D  127  ARG D  133  1                                   7
HELIX   63 AG9 GLY D  144  GLU D  152  1                                   9
HELIX   64 AH1 SER D  155  TRP D  165  1                                  11
HELIX   65 AH2 LEU D  166  TYR D  168  5                                   3
HELIX   66 AH3 CYS D  170  GLY D  174  5                                   5
HELIX   67 AH4 ASP D  186  TYR D  190  5                                   5
HELIX   68 AH5 ASN D  194  GLU D  199  5                                   6
HELIX   69 AH6 ARG D  207  ASN D  212  1                                   6
HELIX   70 AH7 ASN D  266  THR D  269  5                                   4
HELIX   71 AH8 HIS D  270  GLN D  281  1                                  12
HELIX   72 AH9 SER D  284  GLU D  306  1                                  23
HELIX   73 AI1 SER D  354  LEU D  358  5                                   5
HELIX   74 AI2 TYR D  382  ASN D  390  1                                   9
HELIX   75 AI3 THR D  391  GLN D  395  5                                   5
SHEET    1 AA1 7 ALA A 242  LEU A 246  0
SHEET    2 AA1 7 TYR A 176  GLY A 182  1  N  VAL A 179   O  GLY A 244
SHEET    3 AA1 7 LEU A 108  LEU A 114  1  N  LEU A 111   O  PHE A 178
SHEET    4 AA1 7 ARG A  78  HIS A  84  1  N  PHE A  79   O  SER A 109
SHEET    5 AA1 7 MSE A   1  VAL A   6  1  N  ILE A   2   O  ALA A  80
SHEET    6 AA1 7 ILE A  40  TYR A  45  1  O  TYR A  41   N  VAL A   3
SHEET    7 AA1 7 PHE B 453  SER B 456 -1  O  SER B 456   N  LEU A  42
SHEET    1 AA2 6 LEU A 230  ARG A 237  0
SHEET    2 AA2 6 SER A 216  GLU A 223 -1  N  GLU A 223   O  LEU A 230
SHEET    3 AA2 6 GLU A 436  LEU A 444  1  O  MSE A 439   N  LEU A 218
SHEET    4 AA2 6 TYR A 325  ASP A 334  1  N  ILE A 333   O  LEU A 444
SHEET    5 AA2 6 LEU A 376  ASP A 381 -1  O  LEU A 376   N  PHE A 330
SHEET    6 AA2 6 PHE A 363  ARG A 368 -1  N  ASP A 365   O  PHE A 379
SHEET    1 AA3 2 LYS A 308  LYS A 312  0
SHEET    2 AA3 2 THR A 317  ILE A 321 -1  O  ARG A 318   N  VAL A 311
SHEET    1 AA4 3 TYR A 343  THR A 348  0
SHEET    2 AA4 3 LEU A 398  ALA A 404 -1  O  LYS A 403   N  ASP A 344
SHEET    3 AA4 3 LEU A 419  SER A 423 -1  O  PHE A 421   N  PHE A 400
SHEET    1 AA5 2 ALA A 414  TYR A 415  0
SHEET    2 AA5 2 ARG A 447  VAL A 448 -1  O  ARG A 447   N  TYR A 415
SHEET    1 AA6 7 PHE A 453  SER A 456  0
SHEET    2 AA6 7 ILE B  40  TYR B  45 -1  O  LEU B  42   N  SER A 456
SHEET    3 AA6 7 ILE B   2  VAL B   6  1  N  VAL B   3   O  TYR B  41
SHEET    4 AA6 7 PHE B  79  HIS B  84  1  O  ALA B  80   N  ILE B   2
SHEET    5 AA6 7 LEU B 108  LEU B 114  1  O  ILE B 112   N  CYS B  81
SHEET    6 AA6 7 TYR B 176  GLY B 182  1  O  LEU B 180   N  MSE B 113
SHEET    7 AA6 7 ALA B 242  LEU B 246  1  O  LEU B 246   N  THR B 181
SHEET    1 AA7 6 VAL B 231  ARG B 237  0
SHEET    2 AA7 6 SER B 216  GLN B 222 -1  N  LYS B 219   O  LYS B 234
SHEET    3 AA7 6 GLU B 436  LEU B 444  1  O  MSE B 443   N  LEU B 220
SHEET    4 AA7 6 TYR B 325  ASP B 334  1  N  MSE B 327   O  VAL B 438
SHEET    5 AA7 6 LYS B 375  ASP B 381 -1  O  LEU B 376   N  PHE B 330
SHEET    6 AA7 6 PHE B 363  ARG B 368 -1  N  GLN B 367   O  THR B 377
SHEET    1 AA8 2 LYS B 308  LYS B 312  0
SHEET    2 AA8 2 THR B 317  ILE B 321 -1  O  TYR B 320   N  GLU B 309
SHEET    1 AA9 3 TYR B 343  THR B 348  0
SHEET    2 AA9 3 LEU B 398  ALA B 404 -1  O  LYS B 403   N  ASP B 344
SHEET    3 AA9 3 LEU B 419  SER B 423 -1  O  PHE B 421   N  PHE B 400
SHEET    1 AB1 2 ALA B 414  TYR B 415  0
SHEET    2 AB1 2 ARG B 447  VAL B 448 -1  O  ARG B 447   N  TYR B 415
SHEET    1 AB2 7 ALA C 242  VAL C 245  0
SHEET    2 AB2 7 TYR C 176  THR C 181  1  N  VAL C 179   O  GLY C 244
SHEET    3 AB2 7 LEU C 108  LEU C 114  1  N  MSE C 113   O  LEU C 180
SHEET    4 AB2 7 PHE C  79  HIS C  84  1  N  THR C  83   O  ILE C 112
SHEET    5 AB2 7 ILE C   2  VAL C   6  1  N  ILE C   2   O  ALA C  80
SHEET    6 AB2 7 ILE C  40  TYR C  45  1  O  TYR C  41   N  VAL C   3
SHEET    7 AB2 7 PHE D 453  SER D 456 -1  O  ARG D 454   N  ARG C  44
SHEET    1 AB3 6 LEU C 230  ARG C 237  0
SHEET    2 AB3 6 SER C 216  GLU C 223 -1  N  LYS C 219   O  LYS C 234
SHEET    3 AB3 6 THR C 437  LEU C 444  1  O  GLU C 441   N  LEU C 220
SHEET    4 AB3 6 TYR C 325  ASP C 334  1  N  ILE C 329   O  VAL C 440
SHEET    5 AB3 6 LYS C 375  ASP C 381 -1  O  LEU C 376   N  PHE C 330
SHEET    6 AB3 6 PHE C 363  ARG C 368 -1  N  GLN C 367   O  THR C 377
SHEET    1 AB4 2 LYS C 308  THR C 313  0
SHEET    2 AB4 2 PHE C 316  ILE C 321 -1  O  TYR C 320   N  GLU C 309
SHEET    1 AB5 3 TYR C 343  ALA C 349  0
SHEET    2 AB5 3 LEU C 398  ALA C 404 -1  O  GLY C 399   N  THR C 348
SHEET    3 AB5 3 LEU C 419  SER C 423 -1  O  SER C 423   N  LEU C 398
SHEET    1 AB6 2 ALA C 414  TYR C 415  0
SHEET    2 AB6 2 ARG C 447  VAL C 448 -1  O  ARG C 447   N  TYR C 415
SHEET    1 AB7 7 PHE C 453  SER C 456  0
SHEET    2 AB7 7 ILE D  40  TYR D  45 -1  O  LEU D  42   N  SER C 456
SHEET    3 AB7 7 ILE D   2  VAL D   6  1  N  VAL D   3   O  TYR D  41
SHEET    4 AB7 7 PHE D  79  THR D  83  1  O  ALA D  80   N  ILE D   2
SHEET    5 AB7 7 LEU D 108  MSE D 113  1  O  ILE D 112   N  CYS D  81
SHEET    6 AB7 7 TYR D 176  GLY D 182  1  O  LEU D 180   N  MSE D 113
SHEET    7 AB7 7 ALA D 242  LEU D 246  1  O  LEU D 246   N  THR D 181
SHEET    1 AB8 6 LEU D 230  ARG D 237  0
SHEET    2 AB8 6 SER D 216  GLU D 223 -1  N  GLU D 223   O  LEU D 230
SHEET    3 AB8 6 GLU D 436  LEU D 444  1  O  MSE D 439   N  LEU D 218
SHEET    4 AB8 6 TYR D 325  ASP D 334  1  N  MSE D 327   O  VAL D 438
SHEET    5 AB8 6 LEU D 376  ASP D 381 -1  O  LEU D 376   N  PHE D 330
SHEET    6 AB8 6 PHE D 363  ARG D 368 -1  N  ASP D 365   O  PHE D 379
SHEET    1 AB9 2 LYS D 308  LYS D 312  0
SHEET    2 AB9 2 THR D 317  ILE D 321 -1  O  TYR D 320   N  GLU D 309
SHEET    1 AC1 3 LEU D 345  ALA D 349  0
SHEET    2 AC1 3 LEU D 398  VAL D 402 -1  O  GLY D 399   N  THR D 348
SHEET    3 AC1 3 LEU D 419  SER D 423 -1  O  SER D 423   N  LEU D 398
SHEET    1 AC2 2 ALA D 414  TYR D 415  0
SHEET    2 AC2 2 ARG D 447  VAL D 448 -1  O  ARG D 447   N  TYR D 415
LINK         C   THR A   0                 N   MSE A   1     1555   1555  1.33
LINK         C   MSE A   1                 N   ILE A   2     1555   1555  1.33
LINK         C   TRP A  94                 N   MSE A  95     1555   1555  1.33
LINK         C   MSE A  95                 N   ASP A  96     1555   1555  1.34
LINK         C   ILE A 112                 N   MSE A 113     1555   1555  1.33
LINK         C   MSE A 113                 N   LEU A 114     1555   1555  1.34
LINK         C   ASP A 156                 N   MSE A 157     1555   1555  1.33
LINK         C   MSE A 157                 N   SER A 158     1555   1555  1.34
LINK         C   ASN A 212                 N   MSE A 213     1555   1555  1.33
LINK         C   MSE A 213                 N   ASN A 214     1555   1555  1.33
LINK         C   LYS A 234                 N   MSE A 235     1555   1555  1.33
LINK         C   MSE A 235                 N   THR A 236     1555   1555  1.33
LINK         C   PRO A 240                 N   MSE A 241     1555   1555  1.33
LINK         C   MSE A 241                 N   ALA A 242     1555   1555  1.33
LINK         C   THR A 263                 N   MSE A 264     1555   1555  1.33
LINK         C   MSE A 264                 N   ALA A 265     1555   1555  1.34
LINK         C   SER A 326                 N   MSE A 327     1555   1555  1.33
LINK         C   MSE A 327                 N   ILE A 328     1555   1555  1.33
LINK         C   ILE A 384                 N   MSE A 385     1555   1555  1.33
LINK         C   MSE A 385                 N   GLU A 386     1555   1555  1.34
LINK         C   LYS A 393                 N   MSE A 394     1555   1555  1.33
LINK         C   MSE A 394                 N   GLN A 395     1555   1555  1.33
LINK         C   VAL A 438                 N   MSE A 439     1555   1555  1.33
LINK         C   MSE A 439                 N   VAL A 440     1555   1555  1.33
LINK         C   ILE A 442                 N   MSE A 443     1555   1555  1.33
LINK         C   MSE A 443                 N   LEU A 444     1555   1555  1.33
LINK         C   THR B   0                 N   MSE B   1     1555   1555  1.33
LINK         C   MSE B   1                 N   ILE B   2     1555   1555  1.33
LINK         C   TRP B  94                 N   MSE B  95     1555   1555  1.33
LINK         C   MSE B  95                 N   ASP B  96     1555   1555  1.34
LINK         C   ILE B 112                 N   MSE B 113     1555   1555  1.33
LINK         C   MSE B 113                 N   LEU B 114     1555   1555  1.33
LINK         C   ASP B 156                 N   MSE B 157     1555   1555  1.33
LINK         C   MSE B 157                 N   SER B 158     1555   1555  1.34
LINK         C   ASN B 212                 N   MSE B 213     1555   1555  1.33
LINK         C   MSE B 213                 N   ASN B 214     1555   1555  1.33
LINK         C   LYS B 234                 N   MSE B 235     1555   1555  1.33
LINK         C   MSE B 235                 N   THR B 236     1555   1555  1.33
LINK         C   PRO B 240                 N   MSE B 241     1555   1555  1.33
LINK         C   MSE B 241                 N   ALA B 242     1555   1555  1.33
LINK         C   THR B 263                 N   MSE B 264     1555   1555  1.33
LINK         C   MSE B 264                 N   ALA B 265     1555   1555  1.34
LINK         C   SER B 326                 N   MSE B 327     1555   1555  1.33
LINK         C   MSE B 327                 N   ILE B 328     1555   1555  1.33
LINK         C   ILE B 384                 N   MSE B 385     1555   1555  1.33
LINK         C   MSE B 385                 N   GLU B 386     1555   1555  1.33
LINK         C   LYS B 393                 N   MSE B 394     1555   1555  1.33
LINK         C   MSE B 394                 N   GLN B 395     1555   1555  1.33
LINK         C   VAL B 438                 N   MSE B 439     1555   1555  1.33
LINK         C   MSE B 439                 N   VAL B 440     1555   1555  1.33
LINK         C   ILE B 442                 N   MSE B 443     1555   1555  1.33
LINK         C   MSE B 443                 N   LEU B 444     1555   1555  1.33
LINK         C   THR C   0                 N   MSE C   1     1555   1555  1.33
LINK         C   MSE C   1                 N   ILE C   2     1555   1555  1.33
LINK         C   TRP C  94                 N   MSE C  95     1555   1555  1.33
LINK         C   MSE C  95                 N   ASP C  96     1555   1555  1.33
LINK         C   ILE C 112                 N   MSE C 113     1555   1555  1.33
LINK         C   MSE C 113                 N   LEU C 114     1555   1555  1.33
LINK         C   ASP C 156                 N   MSE C 157     1555   1555  1.33
LINK         C   MSE C 157                 N   SER C 158     1555   1555  1.34
LINK         C   ASN C 212                 N   MSE C 213     1555   1555  1.33
LINK         C   MSE C 213                 N   ASN C 214     1555   1555  1.33
LINK         C   LYS C 234                 N   MSE C 235     1555   1555  1.33
LINK         C   MSE C 235                 N   THR C 236     1555   1555  1.33
LINK         C   PRO C 240                 N   MSE C 241     1555   1555  1.33
LINK         C   MSE C 241                 N   ALA C 242     1555   1555  1.33
LINK         C   THR C 263                 N   MSE C 264     1555   1555  1.33
LINK         C   MSE C 264                 N   ALA C 265     1555   1555  1.33
LINK         C   SER C 326                 N   MSE C 327     1555   1555  1.33
LINK         C   MSE C 327                 N   ILE C 328     1555   1555  1.33
LINK         C   ILE C 384                 N   MSE C 385     1555   1555  1.33
LINK         C   MSE C 385                 N   GLU C 386     1555   1555  1.34
LINK         C   LYS C 393                 N   MSE C 394     1555   1555  1.33
LINK         C   MSE C 394                 N   GLN C 395     1555   1555  1.33
LINK         C   VAL C 438                 N   MSE C 439     1555   1555  1.32
LINK         C   MSE C 439                 N   VAL C 440     1555   1555  1.33
LINK         C   ILE C 442                 N   MSE C 443     1555   1555  1.33
LINK         C   MSE C 443                 N   LEU C 444     1555   1555  1.33
LINK         C   THR D   0                 N   MSE D   1     1555   1555  1.33
LINK         C   MSE D   1                 N   ILE D   2     1555   1555  1.33
LINK         C   TRP D  94                 N   MSE D  95     1555   1555  1.33
LINK         C   MSE D  95                 N   ASP D  96     1555   1555  1.34
LINK         C   ILE D 112                 N   MSE D 113     1555   1555  1.33
LINK         C   MSE D 113                 N   LEU D 114     1555   1555  1.33
LINK         C   ASP D 156                 N   MSE D 157     1555   1555  1.33
LINK         C   MSE D 157                 N   SER D 158     1555   1555  1.33
LINK         C   ASN D 212                 N   MSE D 213     1555   1555  1.33
LINK         C   MSE D 213                 N   ASN D 214     1555   1555  1.33
LINK         C   LYS D 234                 N   MSE D 235     1555   1555  1.33
LINK         C   MSE D 235                 N   THR D 236     1555   1555  1.33
LINK         C   PRO D 240                 N   MSE D 241     1555   1555  1.33
LINK         C   MSE D 241                 N   ALA D 242     1555   1555  1.33
LINK         C   THR D 263                 N   MSE D 264     1555   1555  1.33
LINK         C   MSE D 264                 N   ALA D 265     1555   1555  1.33
LINK         C   SER D 326                 N   MSE D 327     1555   1555  1.33
LINK         C   MSE D 327                 N   ILE D 328     1555   1555  1.33
LINK         C   ILE D 384                 N   MSE D 385     1555   1555  1.33
LINK         C   MSE D 385                 N   GLU D 386     1555   1555  1.33
LINK         C   LYS D 393                 N   MSE D 394     1555   1555  1.33
LINK         C   MSE D 394                 N   GLN D 395     1555   1555  1.33
LINK         C   VAL D 438                 N   MSE D 439     1555   1555  1.33
LINK         C   MSE D 439                 N   VAL D 440     1555   1555  1.33
LINK         C   ILE D 442                 N   MSE D 443     1555   1555  1.33
LINK         C   MSE D 443                 N   LEU D 444     1555   1555  1.33
CISPEP   1 TYR A  405    PRO A  406          0        -3.55
CISPEP   2 GLY B  227    GLU B  228          0         2.87
CISPEP   3 TYR B  405    PRO B  406          0        -3.71
CISPEP   4 TYR C  405    PRO C  406          0         2.72
CISPEP   5 TYR D  405    PRO D  406          0        -1.67
CRYST1   75.806  170.578   93.485  90.00  92.86  90.00 P 1 21 1      8
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.013192  0.000000  0.000659        0.00000
SCALE2      0.000000  0.005862  0.000000        0.00000
SCALE3      0.000000  0.000000  0.010710        0.00000
TER    7445      ASP A 474
TER   14863      ASP B 474
TER   22281      ASP C 474
TER   29713      ASP D 474
MASTER      841    0   60   75   80    0    0    615798    4 1548  152
END