longtext: 7b5v-pdb

content
HEADER    HYDROLASE                               07-DEC-20   7B5V
TITLE     THE CARBOHYDRATE BINDING MODULE FAMILY 48 (CBM48) AND CARBOXY-TERMINAL
TITLE    2 CARBOHYDRATE ESTERASE FAMILY 1 (CE1) DOMAINS OF THE MULTIDOMAIN
TITLE    3 ESTERASE DMCE1B FROM DYSGONOMONAS MOSSII
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: CARBOHYDRATE ESTERASE FAMILY 1 PROTEIN WITH AN N-TERMINAL
COMPND   3 CARBOHYDRATE BINDING MODULE FAMILY 48;
COMPND   4 CHAIN: A, B;
COMPND   5 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: DYSGONOMONAS MOSSII DSM 22836;
SOURCE   3 ORGANISM_TAXID: 742767;
SOURCE   4 GENE: HMPREF9456_02279;
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3);
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 469008;
SOURCE   7 EXPRESSION_SYSTEM_PLASMID: PET28A
KEYWDS    CARBOHYDRATE ESTERASE, CE1, CBM48, CARBOHYDRATE BINDING MODULE, CBM,
KEYWDS   2 CE, PUL, LIGNIN, XYLAN, FERULATE, FEROUYL ESTERASE, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    S.MAZURKEWICH,C.KMEZIK,G.BRANDEN,J.LARSBRINK
REVDAT   1   10-MAR-21 7B5V    0
JRNL        AUTH   C.KMEZIK,S.MAZURKEWICH,T.MEENTS,L.S.MCKEE,A.IDSTROM,
JRNL        AUTH 2 M.ARMENI,O.SAVOLAINEN,G.BRANDEN,J.LARSBRINK
JRNL        TITL   A POLYSACCHARIDE UTILIZATION LOCUS FROM THE GUT BACTERIUM
JRNL        TITL 2 DYSGONOMONAS MOSSII ENCODES FUNCTIONALLY DISTINCT
JRNL        TITL 3 CARBOHYDRATE ESTERASES
JRNL        REF    J.BIOL.CHEM.                               2021
JRNL        REFN                   ESSN 1083-351X
JRNL        DOI    10.1016/J.JBC.2021.100500
REMARK   2
REMARK   2 RESOLUTION.    1.70 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX 1.15.2_3472
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : GEOSTD + MONOMER LIBRARY + CDL V1.2
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.70
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 42.08
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.340
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.5
REMARK   3   NUMBER OF REFLECTIONS             : 94391
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.172
REMARK   3   R VALUE            (WORKING SET) : 0.168
REMARK   3   FREE R VALUE                     : 0.211
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 7.500
REMARK   3   FREE R VALUE TEST SET COUNT      : 7079
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 42.0800 -  5.2700    0.99     3004   244  0.1367 0.2040
REMARK   3     2  5.2700 -  4.1800    1.00     2967   241  0.1048 0.1611
REMARK   3     3  4.1800 -  3.6500    1.00     2918   236  0.1286 0.1416
REMARK   3     4  3.6500 -  3.3200    1.00     2968   241  0.1510 0.2112
REMARK   3     5  3.3200 -  3.0800    1.00     2938   238  0.1678 0.2020
REMARK   3     6  3.0800 -  2.9000    1.00     2922   238  0.1810 0.2208
REMARK   3     7  2.9000 -  2.7500    1.00     2916   235  0.1833 0.2336
REMARK   3     8  2.7500 -  2.6300    1.00     2908   236  0.1847 0.2200
REMARK   3     9  2.6300 -  2.5300    1.00     2956   240  0.1893 0.2195
REMARK   3    10  2.5300 -  2.4500    1.00     2901   236  0.1839 0.2104
REMARK   3    11  2.4500 -  2.3700    1.00     2918   236  0.1790 0.2155
REMARK   3    12  2.3700 -  2.3000    1.00     2973   242  0.1758 0.2304
REMARK   3    13  2.3000 -  2.2400    1.00     2884   233  0.1805 0.2094
REMARK   3    14  2.2400 -  2.1900    1.00     2922   237  0.1793 0.2228
REMARK   3    15  2.1900 -  2.1400    1.00     2918   238  0.1747 0.2209
REMARK   3    16  2.1400 -  2.0900    1.00     2932   237  0.1787 0.2327
REMARK   3    17  2.0900 -  2.0500    1.00     2900   235  0.1784 0.2101
REMARK   3    18  2.0500 -  2.0100    1.00     2931   237  0.1845 0.2322
REMARK   3    19  2.0100 -  1.9700    1.00     2918   237  0.1968 0.2298
REMARK   3    20  1.9700 -  1.9400    1.00     2874   234  0.2156 0.2458
REMARK   3    21  1.9400 -  1.9100    1.00     2959   239  0.2405 0.2867
REMARK   3    22  1.9100 -  1.8800    1.00     2863   232  0.2338 0.2943
REMARK   3    23  1.8800 -  1.8500    1.00     2939   238  0.2374 0.2656
REMARK   3    24  1.8500 -  1.8300    1.00     2887   234  0.2481 0.2670
REMARK   3    25  1.8300 -  1.8000    1.00     2930   238  0.2609 0.2953
REMARK   3    26  1.8000 -  1.7800    1.00     2917   236  0.2819 0.2998
REMARK   3    27  1.7800 -  1.7600    1.00     2919   237  0.2938 0.3335
REMARK   3    28  1.7600 -  1.7400    1.00     2858   232  0.3128 0.2982
REMARK   3    29  1.7400 -  1.7200    1.00     2944   239  0.3259 0.3703
REMARK   3    30  1.7200 -  1.7000    0.87     2528   203  0.4008 0.4179
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL
REMARK   3   SOLVENT RADIUS     : 1.11
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.224
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 24.268
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 28.15
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 34.64
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :  0.007           5777
REMARK   3   ANGLE     :  0.875           7827
REMARK   3   CHIRALITY :  0.061            814
REMARK   3   PLANARITY :  0.005           1030
REMARK   3   DIHEDRAL  : 20.040           2118
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 7B5V COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 07-DEC-20.
REMARK 100 THE DEPOSITION ID IS D_1292112713.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 27-MAR-20
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 5
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : MAX IV
REMARK 200  BEAMLINE                       : BIOMAX
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.97625
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : PIXEL
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS EIGER X 16M
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200  DATA SCALING SOFTWARE          : XSCALE
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 94462
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.697
REMARK 200  RESOLUTION RANGE LOW       (A) : 42.080
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.6
REMARK 200  DATA REDUNDANCY                : 6.800
REMARK 200  R MERGE                    (I) : NULL
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 9.3400
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.70
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.76
REMARK 200  COMPLETENESS FOR SHELL     (%) : 96.9
REMARK 200  DATA REDUNDANCY IN SHELL       : 6.70
REMARK 200  R MERGE FOR SHELL          (I) : NULL
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 0.890
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: AUTO-RICKSHAW, MORDA
REMARK 200 STARTING MODEL: 6NE9
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 50.96
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.51
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: JCSG - B9 - 0.1 M CITRATE PH 5, 20%
REMARK 280  PEG 6000, VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 293K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: C 1 2 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,Y,-Z
REMARK 290       3555   X+1/2,Y+1/2,Z
REMARK 290       4555   -X+1/2,Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   3  1.000000  0.000000  0.000000       51.98100
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       40.48300
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   4 -1.000000  0.000000  0.000000       51.98100
REMARK 290   SMTRY2   4  0.000000  1.000000  0.000000       40.48300
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 3910 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 28330 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -18.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 375
REMARK 375 SPECIAL POSITION
REMARK 375 THE FOLLOWING ATOMS ARE FOUND TO BE WITHIN 0.15 ANGSTROMS
REMARK 375 OF A SYMMETRY RELATED ATOM AND ARE ASSUMED TO BE ON SPECIAL
REMARK 375 POSITIONS.
REMARK 375
REMARK 375 ATOM RES CSSEQI
REMARK 375      HOH B 809  LIES ON A SPECIAL POSITION.
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A   271
REMARK 465     GLY A   272
REMARK 465     SER A   273
REMARK 465     SER A   274
REMARK 465     HIS A   275
REMARK 465     HIS A   276
REMARK 465     HIS A   277
REMARK 465     HIS A   278
REMARK 465     HIS A   279
REMARK 465     HIS A   280
REMARK 465     SER A   281
REMARK 465     SER A   282
REMARK 465     GLU A   283
REMARK 465     ASN A   284
REMARK 465     LEU A   285
REMARK 465     TYR A   286
REMARK 465     PHE A   287
REMARK 465     GLN A   288
REMARK 465     GLY A   289
REMARK 465     HIS A   290
REMARK 465     SER A   291
REMARK 465     GLU A   292
REMARK 465     GLU A   293
REMARK 465     SER A   495
REMARK 465     ALA A   496
REMARK 465     ASN A   497
REMARK 465     SER A   498
REMARK 465     PRO A   499
REMARK 465     GLN A   500
REMARK 465     GLY A   501
REMARK 465     LEU A   502
REMARK 465     ARG A   503
REMARK 465     GLY A   504
REMARK 465     LEU A   505
REMARK 465     ILE A   571
REMARK 465     GLU A   572
REMARK 465     MET B   271
REMARK 465     GLY B   272
REMARK 465     SER B   273
REMARK 465     SER B   274
REMARK 465     HIS B   275
REMARK 465     HIS B   276
REMARK 465     HIS B   277
REMARK 465     HIS B   278
REMARK 465     HIS B   279
REMARK 465     HIS B   280
REMARK 465     SER B   281
REMARK 465     SER B   282
REMARK 465     GLU B   283
REMARK 465     ASN B   284
REMARK 465     LEU B   285
REMARK 465     TYR B   286
REMARK 465     PHE B   287
REMARK 465     GLN B   288
REMARK 465     GLY B   289
REMARK 465     HIS B   290
REMARK 465     SER B   291
REMARK 465     SER B   494
REMARK 465     SER B   495
REMARK 465     ALA B   496
REMARK 465     ASN B   497
REMARK 465     SER B   498
REMARK 465     PRO B   499
REMARK 465     GLN B   500
REMARK 465     GLY B   501
REMARK 465     LEU B   502
REMARK 465     ARG B   503
REMARK 465     GLY B   504
REMARK 465     LEU B   505
REMARK 465     PHE B   506
REMARK 465     GLN B   507
REMARK 465     ASN B   508
REMARK 465     GLU B   572
REMARK 465     GLN B   573
REMARK 480
REMARK 480 ZERO OCCUPANCY ATOM
REMARK 480 THE FOLLOWING RESIDUES HAVE ATOMS MODELED WITH ZERO
REMARK 480 OCCUPANCY. THE LOCATION AND PROPERTIES OF THESE ATOMS
REMARK 480 MAY NOT BE RELIABLE. (M=MODEL NUMBER; RES=RESIDUE NAME;
REMARK 480 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):
REMARK 480   M RES C SSEQI ATOMS
REMARK 480     GLU B  292   CB
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    GLU A 295      -41.06   -142.52
REMARK 500    ALA A 324       64.52   -159.92
REMARK 500    GLU A 343     -152.27   -122.63
REMARK 500    ASP A 397       21.24   -144.04
REMARK 500    ASN A 459      -81.99   -103.77
REMARK 500    ASP A 484     -169.76   -111.58
REMARK 500    GLU A 518      -54.48   -124.08
REMARK 500    SER A 542     -119.83     47.32
REMARK 500    ASN A 555       48.02   -142.81
REMARK 500    SER A 637     -150.63   -115.99
REMARK 500    ALA B 324       64.64   -157.88
REMARK 500    GLU B 345       30.03    -91.83
REMARK 500    ASP B 397       20.66   -146.76
REMARK 500    ASN B 459      -83.98   -103.79
REMARK 500    ASP B 484     -167.67   -116.60
REMARK 500    GLU B 518      -59.87   -123.60
REMARK 500    SER B 542     -122.15     49.25
REMARK 500    SER B 637     -151.53   -119.47
REMARK 500
REMARK 500 REMARK: NULL
REMARK 525
REMARK 525 SOLVENT
REMARK 525
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 525 NUMBER; I=INSERTION CODE):
REMARK 525
REMARK 525  M RES CSSEQI
REMARK 525    HOH B1134        DISTANCE =  6.37 ANGSTROMS
REMARK 525    HOH B1135        DISTANCE =  6.56 ANGSTROMS
REMARK 525    HOH B1136        DISTANCE =  6.89 ANGSTROMS
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue CL A 701
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue PEG A 702
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO B 701
DBREF  7B5V A  292   656  UNP    F8X1N1   F8X1N1_9BACT   292    656
DBREF  7B5V B  292   656  UNP    F8X1N1   F8X1N1_9BACT   292    656
SEQADV 7B5V MET A  271  UNP  F8X1N1              INITIATING METHIONINE
SEQADV 7B5V GLY A  272  UNP  F8X1N1              EXPRESSION TAG
SEQADV 7B5V SER A  273  UNP  F8X1N1              EXPRESSION TAG
SEQADV 7B5V SER A  274  UNP  F8X1N1              EXPRESSION TAG
SEQADV 7B5V HIS A  275  UNP  F8X1N1              EXPRESSION TAG
SEQADV 7B5V HIS A  276  UNP  F8X1N1              EXPRESSION TAG
SEQADV 7B5V HIS A  277  UNP  F8X1N1              EXPRESSION TAG
SEQADV 7B5V HIS A  278  UNP  F8X1N1              EXPRESSION TAG
SEQADV 7B5V HIS A  279  UNP  F8X1N1              EXPRESSION TAG
SEQADV 7B5V HIS A  280  UNP  F8X1N1              EXPRESSION TAG
SEQADV 7B5V SER A  281  UNP  F8X1N1              EXPRESSION TAG
SEQADV 7B5V SER A  282  UNP  F8X1N1              EXPRESSION TAG
SEQADV 7B5V GLU A  283  UNP  F8X1N1              EXPRESSION TAG
SEQADV 7B5V ASN A  284  UNP  F8X1N1              EXPRESSION TAG
SEQADV 7B5V LEU A  285  UNP  F8X1N1              EXPRESSION TAG
SEQADV 7B5V TYR A  286  UNP  F8X1N1              EXPRESSION TAG
SEQADV 7B5V PHE A  287  UNP  F8X1N1              EXPRESSION TAG
SEQADV 7B5V GLN A  288  UNP  F8X1N1              EXPRESSION TAG
SEQADV 7B5V GLY A  289  UNP  F8X1N1              EXPRESSION TAG
SEQADV 7B5V HIS A  290  UNP  F8X1N1              EXPRESSION TAG
SEQADV 7B5V SER A  291  UNP  F8X1N1              EXPRESSION TAG
SEQADV 7B5V MET B  271  UNP  F8X1N1              INITIATING METHIONINE
SEQADV 7B5V GLY B  272  UNP  F8X1N1              EXPRESSION TAG
SEQADV 7B5V SER B  273  UNP  F8X1N1              EXPRESSION TAG
SEQADV 7B5V SER B  274  UNP  F8X1N1              EXPRESSION TAG
SEQADV 7B5V HIS B  275  UNP  F8X1N1              EXPRESSION TAG
SEQADV 7B5V HIS B  276  UNP  F8X1N1              EXPRESSION TAG
SEQADV 7B5V HIS B  277  UNP  F8X1N1              EXPRESSION TAG
SEQADV 7B5V HIS B  278  UNP  F8X1N1              EXPRESSION TAG
SEQADV 7B5V HIS B  279  UNP  F8X1N1              EXPRESSION TAG
SEQADV 7B5V HIS B  280  UNP  F8X1N1              EXPRESSION TAG
SEQADV 7B5V SER B  281  UNP  F8X1N1              EXPRESSION TAG
SEQADV 7B5V SER B  282  UNP  F8X1N1              EXPRESSION TAG
SEQADV 7B5V GLU B  283  UNP  F8X1N1              EXPRESSION TAG
SEQADV 7B5V ASN B  284  UNP  F8X1N1              EXPRESSION TAG
SEQADV 7B5V LEU B  285  UNP  F8X1N1              EXPRESSION TAG
SEQADV 7B5V TYR B  286  UNP  F8X1N1              EXPRESSION TAG
SEQADV 7B5V PHE B  287  UNP  F8X1N1              EXPRESSION TAG
SEQADV 7B5V GLN B  288  UNP  F8X1N1              EXPRESSION TAG
SEQADV 7B5V GLY B  289  UNP  F8X1N1              EXPRESSION TAG
SEQADV 7B5V HIS B  290  UNP  F8X1N1              EXPRESSION TAG
SEQADV 7B5V SER B  291  UNP  F8X1N1              EXPRESSION TAG
SEQRES   1 A  386  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLU
SEQRES   2 A  386  ASN LEU TYR PHE GLN GLY HIS SER GLU GLU ALA GLU VAL
SEQRES   3 A  386  GLY ILE SER ALA SER THR ASN ILE PRO GLY ALA GLN TYR
SEQRES   4 A  386  PRO GLN ILE LEU SER GLY ASN ARG VAL LEU PHE ARG ILE
SEQRES   5 A  386  LYS ALA PRO ASP ALA LYS ARG VAL GLN VAL ASP LEU GLY
SEQRES   6 A  386  LYS LYS TYR ASP MET VAL ARG GLU GLU GLU GLY SER TRP
SEQRES   7 A  386  ALA ILE THR THR ASP PRO ILE VAL GLU GLY PHE HIS TYR
SEQRES   8 A  386  TYR SER ILE LEU ILE ASP GLY VAL ALA VAL CYS ASP PRO
SEQRES   9 A  386  ALA SER ARG THR PHE TYR GLY MET SER ARG MET ALA SER
SEQRES  10 A  386  GLY ILE GLU ILE PRO GLU GLU GLY VAL ASP TYR TYR ASN
SEQRES  11 A  386  LEU LYS ASN VAL PRO HIS GLY GLN ILE ARG GLN ILE ARG
SEQRES  12 A  386  TYR PHE SER ASP VAL THR LYS ALA TRP ARG ARG ALA PHE
SEQRES  13 A  386  VAL TYR THR PRO ALA GLY TYR ASP ALA ASN THR SER GLN
SEQRES  14 A  386  ARG TYR PRO VAL LEU TYR LEU GLN HIS GLY GLY GLY GLU
SEQRES  15 A  386  ASP GLU THR GLY TRP PRO ASN GLN GLY LYS MET ASP ALA
SEQRES  16 A  386  ILE ILE ASP ASN LEU ILE ALA GLU GLY LYS ALA LYS PRO
SEQRES  17 A  386  MET ILE VAL VAL MET ASP ASN GLY TYR ALA VAL ASP PRO
SEQRES  18 A  386  SER ALA SER SER ALA ASN SER PRO GLN GLY LEU ARG GLY
SEQRES  19 A  386  LEU PHE GLN ASN SER ALA LEU GLU LYS VAL PHE ILE ASN
SEQRES  20 A  386  GLU ILE ILE PRO LEU VAL ASP LYS GLU PHE ARG THR ILE
SEQRES  21 A  386  ALA ASP ARG ASP HIS ARG ALA MET ALA GLY LEU SER MET
SEQRES  22 A  386  GLY GLY PHE GLN ALA PHE GLN ILE ALA MET THR ASN LEU
SEQRES  23 A  386  ASP LYS PHE ALA TYR VAL GLY GLY PHE SER GLY GLY GLY
SEQRES  24 A  386  ILE ILE GLU GLN GLY GLY ASP PHE SER LYS MET TYR ASN
SEQRES  25 A  386  ASN VAL TRP SER ASP VAL ASP THR PHE ASN LYS ARG VAL
SEQRES  26 A  386  LYS LEU ILE TYR LEU SER ILE GLY THR ALA GLU PRO THR
SEQRES  27 A  386  ASN MET TYR GLN THR VAL ASN ASN PHE HIS LYS GLU PHE
SEQRES  28 A  386  GLU LYS ALA GLY ILE LYS HIS VAL TYR TYR GLU SER PRO
SEQRES  29 A  386  GLY THR SER HIS GLU TRP LEU THR TRP ARG ARG SER LEU
SEQRES  30 A  386  ASN GLN PHE ALA GLU LEU LEU PHE LYS
SEQRES   1 B  386  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLU
SEQRES   2 B  386  ASN LEU TYR PHE GLN GLY HIS SER GLU GLU ALA GLU VAL
SEQRES   3 B  386  GLY ILE SER ALA SER THR ASN ILE PRO GLY ALA GLN TYR
SEQRES   4 B  386  PRO GLN ILE LEU SER GLY ASN ARG VAL LEU PHE ARG ILE
SEQRES   5 B  386  LYS ALA PRO ASP ALA LYS ARG VAL GLN VAL ASP LEU GLY
SEQRES   6 B  386  LYS LYS TYR ASP MET VAL ARG GLU GLU GLU GLY SER TRP
SEQRES   7 B  386  ALA ILE THR THR ASP PRO ILE VAL GLU GLY PHE HIS TYR
SEQRES   8 B  386  TYR SER ILE LEU ILE ASP GLY VAL ALA VAL CYS ASP PRO
SEQRES   9 B  386  ALA SER ARG THR PHE TYR GLY MET SER ARG MET ALA SER
SEQRES  10 B  386  GLY ILE GLU ILE PRO GLU GLU GLY VAL ASP TYR TYR ASN
SEQRES  11 B  386  LEU LYS ASN VAL PRO HIS GLY GLN ILE ARG GLN ILE ARG
SEQRES  12 B  386  TYR PHE SER ASP VAL THR LYS ALA TRP ARG ARG ALA PHE
SEQRES  13 B  386  VAL TYR THR PRO ALA GLY TYR ASP ALA ASN THR SER GLN
SEQRES  14 B  386  ARG TYR PRO VAL LEU TYR LEU GLN HIS GLY GLY GLY GLU
SEQRES  15 B  386  ASP GLU THR GLY TRP PRO ASN GLN GLY LYS MET ASP ALA
SEQRES  16 B  386  ILE ILE ASP ASN LEU ILE ALA GLU GLY LYS ALA LYS PRO
SEQRES  17 B  386  MET ILE VAL VAL MET ASP ASN GLY TYR ALA VAL ASP PRO
SEQRES  18 B  386  SER ALA SER SER ALA ASN SER PRO GLN GLY LEU ARG GLY
SEQRES  19 B  386  LEU PHE GLN ASN SER ALA LEU GLU LYS VAL PHE ILE ASN
SEQRES  20 B  386  GLU ILE ILE PRO LEU VAL ASP LYS GLU PHE ARG THR ILE
SEQRES  21 B  386  ALA ASP ARG ASP HIS ARG ALA MET ALA GLY LEU SER MET
SEQRES  22 B  386  GLY GLY PHE GLN ALA PHE GLN ILE ALA MET THR ASN LEU
SEQRES  23 B  386  ASP LYS PHE ALA TYR VAL GLY GLY PHE SER GLY GLY GLY
SEQRES  24 B  386  ILE ILE GLU GLN GLY GLY ASP PHE SER LYS MET TYR ASN
SEQRES  25 B  386  ASN VAL TRP SER ASP VAL ASP THR PHE ASN LYS ARG VAL
SEQRES  26 B  386  LYS LEU ILE TYR LEU SER ILE GLY THR ALA GLU PRO THR
SEQRES  27 B  386  ASN MET TYR GLN THR VAL ASN ASN PHE HIS LYS GLU PHE
SEQRES  28 B  386  GLU LYS ALA GLY ILE LYS HIS VAL TYR TYR GLU SER PRO
SEQRES  29 B  386  GLY THR SER HIS GLU TRP LEU THR TRP ARG ARG SER LEU
SEQRES  30 B  386  ASN GLN PHE ALA GLU LEU LEU PHE LYS
HET     CL  A 701       1
HET    PEG  A 702       7
HET    EDO  B 701       4
HETNAM      CL CHLORIDE ION
HETNAM     PEG DI(HYDROXYETHYL)ETHER
HETNAM     EDO 1,2-ETHANEDIOL
HETSYN     EDO ETHYLENE GLYCOL
FORMUL   3   CL    CL 1-
FORMUL   4  PEG    C4 H10 O3
FORMUL   5  EDO    C2 H6 O2
FORMUL   6  HOH   *648(H2 O)
HELIX    1 AA1 SER A  314  ASN A  316  5                                   3
HELIX    2 AA2 LYS A  462  GLU A  473  1                                  12
HELIX    3 AA3 ASN A  508  GLU A  518  1                                  11
HELIX    4 AA4 GLU A  518  PHE A  527  1                                  10
HELIX    5 AA5 ASP A  532  ASP A  534  5                                   3
HELIX    6 AA6 SER A  542  THR A  554  1                                  13
HELIX    7 AA7 ASP A  576  SER A  578  5                                   3
HELIX    8 AA8 LYS A  579  VAL A  584  1                                   6
HELIX    9 AA9 ASP A  587  VAL A  595  1                                   9
HELIX   10 AB1 PRO A  607  GLY A  625  1                                  19
HELIX   11 AB2 GLU A  639  LEU A  654  1                                  16
HELIX   12 AB3 LYS B  462  GLU B  473  1                                  12
HELIX   13 AB4 ALA B  510  GLU B  518  1                                   9
HELIX   14 AB5 GLU B  518  PHE B  527  1                                  10
HELIX   15 AB6 ASP B  532  ASP B  534  5                                   3
HELIX   16 AB7 SER B  542  THR B  554  1                                  13
HELIX   17 AB8 ASP B  576  SER B  578  5                                   3
HELIX   18 AB9 LYS B  579  VAL B  584  1                                   6
HELIX   19 AC1 ASP B  587  VAL B  595  1                                   9
HELIX   20 AC2 PRO B  607  GLY B  625  1                                  19
HELIX   21 AC3 GLU B  639  LEU B  654  1                                  16
SHEET    1 AA1 5 ILE A 298  SER A 299  0
SHEET    2 AA1 5 GLN A 311  ILE A 312 -1  O  ILE A 312   N  ILE A 298
SHEET    3 AA1 5 VAL A 318  LYS A 323 -1  O  LEU A 319   N  GLN A 311
SHEET    4 AA1 5 SER A 347  THR A 351 -1  O  TRP A 348   N  ILE A 322
SHEET    5 AA1 5 VAL A 341  ARG A 342 -1  N  VAL A 341   O  ALA A 349
SHEET    1 AA2 4 LYS A 337  ASP A 339  0
SHEET    2 AA2 4 VAL A 330  ASP A 333 -1  N  VAL A 332   O  TYR A 338
SHEET    3 AA2 4 GLY A 358  ILE A 366 -1  O  SER A 363   N  ASP A 333
SHEET    4 AA2 4 VAL A 369  VAL A 371 -1  O  VAL A 371   N  ILE A 364
SHEET    1 AA3 5 LYS A 337  ASP A 339  0
SHEET    2 AA3 5 VAL A 330  ASP A 333 -1  N  VAL A 332   O  TYR A 338
SHEET    3 AA3 5 GLY A 358  ILE A 366 -1  O  SER A 363   N  ASP A 333
SHEET    4 AA3 5 ARG A 384  ILE A 391 -1  O  ILE A 391   N  GLY A 358
SHEET    5 AA3 5 THR A 378  GLY A 381 -1  N  PHE A 379   O  ALA A 386
SHEET    1 AA416 VAL A 629  SER A 633  0
SHEET    2 AA416 LEU A 597  GLY A 603  1  N  ILE A 598   O  VAL A 629
SHEET    3 AA416 TYR A 561  PHE A 565  1  N  GLY A 564   O  TYR A 599
SHEET    4 AA416 ARG A 536  LEU A 541  1  N  GLY A 540   O  PHE A 565
SHEET    5 AA416 VAL A 443  GLN A 447  1  N  TYR A 445   O  ALA A 539
SHEET    6 AA416 ILE A 480  MET A 483  1  O  VAL A 482   N  LEU A 446
SHEET    7 AA416 ALA A 421  THR A 429 -1  N  PHE A 426   O  MET A 483
SHEET    8 AA416 GLN A 408  SER A 416 -1  N  TYR A 414   O  ARG A 423
SHEET    9 AA416 GLN B 408  PHE B 415 -1  O  GLN B 411   N  ILE A 409
SHEET   10 AA416 TRP B 422  THR B 429 -1  O  ARG B 423   N  TYR B 414
SHEET   11 AA416 ILE B 480  MET B 483 -1  O  MET B 483   N  PHE B 426
SHEET   12 AA416 VAL B 443  GLN B 447  1  N  LEU B 446   O  VAL B 482
SHEET   13 AA416 ARG B 536  LEU B 541  1  O  ALA B 539   N  TYR B 445
SHEET   14 AA416 TYR B 561  PHE B 565  1  O  PHE B 565   N  GLY B 540
SHEET   15 AA416 LEU B 597  GLY B 603  1  O  TYR B 599   N  GLY B 564
SHEET   16 AA416 VAL B 629  SER B 633  1  O  SER B 633   N  ILE B 602
SHEET    1 AA5 5 ILE B 298  SER B 299  0
SHEET    2 AA5 5 GLN B 311  ILE B 312 -1  O  ILE B 312   N  ILE B 298
SHEET    3 AA5 5 ARG B 317  LYS B 323 -1  O  LEU B 319   N  GLN B 311
SHEET    4 AA5 5 SER B 347  PRO B 354 -1  O  TRP B 348   N  ILE B 322
SHEET    5 AA5 5 VAL B 341  ARG B 342 -1  N  VAL B 341   O  ALA B 349
SHEET    1 AA6 4 LYS B 337  ASP B 339  0
SHEET    2 AA6 4 VAL B 330  ASP B 333 -1  N  VAL B 332   O  TYR B 338
SHEET    3 AA6 4 GLY B 358  ILE B 366 -1  O  LEU B 365   N  GLN B 331
SHEET    4 AA6 4 VAL B 369  VAL B 371 -1  O  VAL B 371   N  ILE B 364
SHEET    1 AA7 5 LYS B 337  ASP B 339  0
SHEET    2 AA7 5 VAL B 330  ASP B 333 -1  N  VAL B 332   O  TYR B 338
SHEET    3 AA7 5 GLY B 358  ILE B 366 -1  O  LEU B 365   N  GLN B 331
SHEET    4 AA7 5 ARG B 384  ILE B 391 -1  O  ILE B 391   N  GLY B 358
SHEET    5 AA7 5 THR B 378  GLY B 381 -1  N  PHE B 379   O  ALA B 386
CISPEP   1 TYR A  309    PRO A  310          0         4.36
CISPEP   2 TYR B  309    PRO B  310          0         5.33
SITE     1 AC1  4 GLY A 450  SER A 542  MET A 543  HOH A 997
SITE     1 AC2  7 GLY A 306  ALA A 307  GLN A 308  TYR A 309
SITE     2 AC2  7 ALA A 375  HOH A 811  HOH A 913
SITE     1 AC3  4 ASP A 326  ARG B 329  ASP B 367  GLY B 368
CRYST1  103.962   80.966  107.350  90.00 105.67  90.00 C 1 2 1       8
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.009619  0.000000  0.002698        0.00000
SCALE2      0.000000  0.012351  0.000000        0.00000
SCALE3      0.000000  0.000000  0.009675        0.00000
TER    2816      LYS A 656
TER    5624      LYS B 656
MASTER      381    0    3   21   44    0    4    6 6191    2   11   60
END