longtext: 7dzt-pdb

content
HEADER    HYDROLASE                               26-JAN-21   7DZT
TITLE     CYRSTAL STRUCTURE OF PETASE FROM RHIZOBACTER GUMMIPHILUS
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: DLH DOMAIN-CONTAINING PROTEIN;
COMPND   3 CHAIN: A, B;
COMPND   4 FRAGMENT: PET HYDROLASE;
COMPND   5 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: RHIZOBACTER GUMMIPHILUS;
SOURCE   3 ORGANISM_COMMON: METHYLIBIUM SP. NS21;
SOURCE   4 ORGANISM_TAXID: 946333;
SOURCE   5 STRAIN: NS21;
SOURCE   6 GENE: A4W93_05950;
SOURCE   7 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   8 EXPRESSION_SYSTEM_TAXID: 562;
SOURCE   9 EXPRESSION_SYSTEM_STRAIN: ROSETTA GAMI-B
KEYWDS    PET HYDROLASE, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    H.-Y.SAGONG,K.-J.KIM
REVDAT   1   07-JUL-21 7DZT    0
JRNL        AUTH   H.-Y.SAGONG,H.F.SON,H.SEO,H.HONG,D.LEE,K.-J.KIM
JRNL        TITL   IMPLICATIONS FOR THE PET DECOMPOSITION MECHANISM THROUGH
JRNL        TITL 2 SIMILARITY AND DISSIMILARITY BETWEEN PETASES FROM
JRNL        TITL 3 RHIZOBACTER GUMMIPHILUS AND IDEONELLA SAKAIENSIS.
JRNL        REF    J HAZARD MATER                             2021
JRNL        REFN                   ISSN 1873-3336
JRNL        DOI    10.1016/J.JHAZMAT.2021.126075
REMARK   2
REMARK   2 RESOLUTION.    2.35 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.8.0258
REMARK   3   AUTHORS     : MURSHUDOV,SKUBAK,LEBEDEV,PANNU,STEINER,
REMARK   3               : NICHOLLS,WINN,LONG,VAGIN
REMARK   3
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.35
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 32.90
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0.000
REMARK   3   COMPLETENESS FOR RANGE        (%) : 98.8
REMARK   3   NUMBER OF REFLECTIONS             : 20943
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.203
REMARK   3   R VALUE            (WORKING SET) : 0.200
REMARK   3   FREE R VALUE                     : 0.265
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.900
REMARK   3   FREE R VALUE TEST SET COUNT      : 1084
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 2.35
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 2.41
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 1467
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 94.95
REMARK   3   BIN R VALUE           (WORKING SET) : 0.2370
REMARK   3   BIN FREE R VALUE SET COUNT          : 75
REMARK   3   BIN FREE R VALUE                    : 0.3320
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 3990
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 0
REMARK   3   SOLVENT ATOMS            : 125
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 36.91
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : -1.05000
REMARK   3    B22 (A**2) : -1.37000
REMARK   3    B33 (A**2) : 2.42000
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : 0.00000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): 0.459
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.282
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.208
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 8.958
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.945
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.898
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A):  4092 ; 0.007 ; 0.013
REMARK   3   BOND LENGTHS OTHERS               (A):  3610 ; 0.001 ; 0.017
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES):  5570 ; 1.548 ; 1.642
REMARK   3   BOND ANGLES OTHERS          (DEGREES):  8406 ; 1.259 ; 1.569
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):   532 ; 7.506 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   192 ;32.821 ;21.667
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):   614 ;14.457 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):    26 ;17.278 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):   538 ; 0.066 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A):  4686 ; 0.006 ; 0.020
REMARK   3   GENERAL PLANES OTHERS             (A):   872 ; 0.001 ; 0.020
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN ANGLE OTHER ATOMS   (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN ANGLE OTHER ATOMS   (A**2):  NULL ;  NULL ;  NULL
REMARK   3   LONG RANGE B REFINED ATOMS     (A**2):  NULL ;  NULL ;  NULL
REMARK   3   LONG RANGE B OTHER ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : MASK
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.20
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE RIDING
REMARK   3  POSITIONS U VALUES : REFINED INDIVIDUALLY
REMARK   4
REMARK   4 7DZT COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 28-JAN-21.
REMARK 100 THE DEPOSITION ID IS D_1300020508.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 23-MAY-20
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 5.0
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : PAL/PLS
REMARK 200  BEAMLINE                       : 7A (6B, 6C1)
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.97934
REMARK 200  MONOCHROMATOR                  : DOUBLE CRYSTAL MONOCHROMATOR
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 270
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000
REMARK 200  DATA SCALING SOFTWARE          : HKL-2000
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 22066
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.350
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.2
REMARK 200  DATA REDUNDANCY                : 6.500
REMARK 200  R MERGE                    (I) : 0.11400
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 19.2000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.35
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.39
REMARK 200  COMPLETENESS FOR SHELL     (%) : 100.0
REMARK 200  DATA REDUNDANCY IN SHELL       : 6.70
REMARK 200  R MERGE FOR SHELL          (I) : 0.28900
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: MOLREP
REMARK 200 STARTING MODEL: 5XJH
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 46.75
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.31
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: PEG 3350, BIS-TRIS, PH 5.0,
REMARK 280  EVAPORATION, TEMPERATURE 298K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: C 2 2 21
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,-Y,Z+1/2
REMARK 290       3555   -X,Y,-Z+1/2
REMARK 290       4555   X,-Y,-Z
REMARK 290       5555   X+1/2,Y+1/2,Z
REMARK 290       6555   -X+1/2,-Y+1/2,Z+1/2
REMARK 290       7555   -X+1/2,Y+1/2,-Z+1/2
REMARK 290       8555   X+1/2,-Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000      100.35650
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000      100.35650
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   5  1.000000  0.000000  0.000000       34.63350
REMARK 290   SMTRY2   5  0.000000  1.000000  0.000000       37.75600
REMARK 290   SMTRY3   5  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   6 -1.000000  0.000000  0.000000       34.63350
REMARK 290   SMTRY2   6  0.000000 -1.000000  0.000000       37.75600
REMARK 290   SMTRY3   6  0.000000  0.000000  1.000000      100.35650
REMARK 290   SMTRY1   7 -1.000000  0.000000  0.000000       34.63350
REMARK 290   SMTRY2   7  0.000000  1.000000  0.000000       37.75600
REMARK 290   SMTRY3   7  0.000000  0.000000 -1.000000      100.35650
REMARK 290   SMTRY1   8  1.000000  0.000000  0.000000       34.63350
REMARK 290   SMTRY2   8  0.000000 -1.000000  0.000000       37.75600
REMARK 290   SMTRY3   8  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     GLU A   294
REMARK 465     GLU B   294
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    THR A  86      -12.20     75.35
REMARK 500    SER A 158     -123.66     57.15
REMARK 500    GLN A 185       50.41   -112.07
REMARK 500    ALA A 206       69.93   -117.38
REMARK 500    HIS A 211      -95.30   -131.56
REMARK 500    ASP B  35      134.76    -36.98
REMARK 500    THR B  86      -11.64     76.94
REMARK 500    TYR B 144      121.01    -32.17
REMARK 500    ASP B 148       96.98    -67.20
REMARK 500    SER B 158     -119.60     66.37
REMARK 500    HIS B 211      -86.60   -122.17
REMARK 500
REMARK 500 REMARK: NULL
DBREF1 7DZT A   27   292  UNP                  A0A1W6L588_9BURK
DBREF2 7DZT A     A0A1W6L588                         27         292
DBREF1 7DZT B   27   292  UNP                  A0A1W6L588_9BURK
DBREF2 7DZT B     A0A1W6L588                         27         292
SEQADV 7DZT LEU A  293  UNP  A0A1W6L58           EXPRESSION TAG
SEQADV 7DZT GLU A  294  UNP  A0A1W6L58           EXPRESSION TAG
SEQADV 7DZT LEU B  293  UNP  A0A1W6L58           EXPRESSION TAG
SEQADV 7DZT GLU B  294  UNP  A0A1W6L58           EXPRESSION TAG
SEQRES   1 A  268  THR ASN PRO TYR GLN ARG GLY PRO ASP PRO THR VAL SER
SEQRES   2 A  268  SER LEU GLU ALA THR ARG GLY PRO PHE SER THR SER SER
SEQRES   3 A  268  PHE THR VAL SER ARG PRO SER GLY TYR GLY ALA GLY THR
SEQRES   4 A  268  VAL TYR TYR PRO THR ASN ALA GLY GLY LYS VAL GLY ALA
SEQRES   5 A  268  ILE ALA VAL VAL PRO GLY TYR THR ALA ARG GLN SER SER
SEQRES   6 A  268  ILE ASN TRP TRP GLY PRO ARG LEU ALA SER HIS GLY PHE
SEQRES   7 A  268  VAL VAL ILE THR ILE ASP THR ASN SER THR LEU ASP GLN
SEQRES   8 A  268  PRO SER SER ARG SER SER GLN GLN MET ALA ALA LEU ARG
SEQRES   9 A  268  GLN VAL VAL SER LEU ALA GLY THR SER SER SER PRO ILE
SEQRES  10 A  268  TYR ASN LYS VAL ASP THR ALA ARG LEU GLY VAL MET GLY
SEQRES  11 A  268  TRP SER MET GLY GLY GLY GLY SER LEU ILE SER ALA LYS
SEQRES  12 A  268  ASN ASN PRO SER LEU ARG ALA ALA ALA PRO GLN ALA PRO
SEQRES  13 A  268  TRP ALA GLN GLU SER PHE SER SER VAL THR VAL PRO THR
SEQRES  14 A  268  LEU ILE VAL SER CYS GLU ASN ASP SER ILE ALA PRO ASN
SEQRES  15 A  268  SER SER HIS SER PHE PRO PHE TYR ASN GLN MET THR ARG
SEQRES  16 A  268  ASN LYS LYS ALA ASN LEU VAL ILE ASN GLY GLY SER HIS
SEQRES  17 A  268  SER CYS ALA ASN SER GLY ASN SER ASP ALA GLY LEU ILE
SEQRES  18 A  268  GLY LYS TYR GLY VAL ALA TRP MET LYS ARG PHE MET ASP
SEQRES  19 A  268  ASP ASP THR ARG TYR SER LYS PHE LEU CYS GLY ALA GLU
SEQRES  20 A  268  HIS GLN ALA ASP LEU SER LYS ARG ALA VAL GLU ALA TYR
SEQRES  21 A  268  LYS GLU ASN CYS PRO TYR LEU GLU
SEQRES   1 B  268  THR ASN PRO TYR GLN ARG GLY PRO ASP PRO THR VAL SER
SEQRES   2 B  268  SER LEU GLU ALA THR ARG GLY PRO PHE SER THR SER SER
SEQRES   3 B  268  PHE THR VAL SER ARG PRO SER GLY TYR GLY ALA GLY THR
SEQRES   4 B  268  VAL TYR TYR PRO THR ASN ALA GLY GLY LYS VAL GLY ALA
SEQRES   5 B  268  ILE ALA VAL VAL PRO GLY TYR THR ALA ARG GLN SER SER
SEQRES   6 B  268  ILE ASN TRP TRP GLY PRO ARG LEU ALA SER HIS GLY PHE
SEQRES   7 B  268  VAL VAL ILE THR ILE ASP THR ASN SER THR LEU ASP GLN
SEQRES   8 B  268  PRO SER SER ARG SER SER GLN GLN MET ALA ALA LEU ARG
SEQRES   9 B  268  GLN VAL VAL SER LEU ALA GLY THR SER SER SER PRO ILE
SEQRES  10 B  268  TYR ASN LYS VAL ASP THR ALA ARG LEU GLY VAL MET GLY
SEQRES  11 B  268  TRP SER MET GLY GLY GLY GLY SER LEU ILE SER ALA LYS
SEQRES  12 B  268  ASN ASN PRO SER LEU ARG ALA ALA ALA PRO GLN ALA PRO
SEQRES  13 B  268  TRP ALA GLN GLU SER PHE SER SER VAL THR VAL PRO THR
SEQRES  14 B  268  LEU ILE VAL SER CYS GLU ASN ASP SER ILE ALA PRO ASN
SEQRES  15 B  268  SER SER HIS SER PHE PRO PHE TYR ASN GLN MET THR ARG
SEQRES  16 B  268  ASN LYS LYS ALA ASN LEU VAL ILE ASN GLY GLY SER HIS
SEQRES  17 B  268  SER CYS ALA ASN SER GLY ASN SER ASP ALA GLY LEU ILE
SEQRES  18 B  268  GLY LYS TYR GLY VAL ALA TRP MET LYS ARG PHE MET ASP
SEQRES  19 B  268  ASP ASP THR ARG TYR SER LYS PHE LEU CYS GLY ALA GLU
SEQRES  20 B  268  HIS GLN ALA ASP LEU SER LYS ARG ALA VAL GLU ALA TYR
SEQRES  21 B  268  LYS GLU ASN CYS PRO TYR LEU GLU
FORMUL   3  HOH   *125(H2 O)
HELIX    1 AA1 THR A   37  ALA A   43  1                                   7
HELIX    2 AA2 ARG A   88  ASN A   93  1                                   6
HELIX    3 AA3 TRP A   94  SER A  101  1                                   8
HELIX    4 AA4 GLN A  117  GLY A  137  1                                  21
HELIX    5 AA5 SER A  158  ASN A  171  1                                  14
HELIX    6 AA6 PRO A  207  SER A  210  5                                   4
HELIX    7 AA7 HIS A  211  MET A  219  1                                   9
HELIX    8 AA8 ASP A  243  ASP A  260  1                                  18
HELIX    9 AA9 ASP A  262  ARG A  264  5                                   3
HELIX   10 AB1 TYR A  265  GLY A  271  1                                   7
HELIX   11 AB2 GLY A  271  ASP A  277  1                                   7
HELIX   12 AB3 LEU A  278  LYS A  280  5                                   3
HELIX   13 AB4 THR B   37  ALA B   43  1                                   7
HELIX   14 AB5 ARG B   88  ASN B   93  1                                   6
HELIX   15 AB6 TRP B   94  SER B  101  1                                   8
HELIX   16 AB7 GLN B  117  ALA B  136  1                                  20
HELIX   17 AB8 SER B  158  ASN B  171  1                                  14
HELIX   18 AB9 HIS B  211  MET B  219  1                                   9
HELIX   19 AC1 ASP B  243  ASP B  260  1                                  18
HELIX   20 AC2 SER B  266  GLY B  271  1                                   6
HELIX   21 AC3 GLY B  271  ALA B  276  1                                   6
SHEET    1 AA1 6 THR A  50  THR A  54  0
SHEET    2 AA1 6 ALA A  63  PRO A  69 -1  O  VAL A  66   N  PHE A  53
SHEET    3 AA1 6 VAL A 105  ASP A 110 -1  O  VAL A 106   N  TYR A  67
SHEET    4 AA1 6 VAL A  76  VAL A  82  1  N  VAL A  81   O  ILE A 107
SHEET    5 AA1 6 VAL A 147  TRP A 157  1  O  ASP A 148   N  VAL A  76
SHEET    6 AA1 6 ALA A 176  GLN A 180  1  O  GLN A 180   N  GLY A 156
SHEET    1 AA2 3 THR A 195  CYS A 200  0
SHEET    2 AA2 3 LYS A 224  ILE A 229  1  O  LEU A 227   N  SER A 199
SHEET    3 AA2 3 VAL A 283  GLU A 288 -1  O  ALA A 285   N  VAL A 228
SHEET    1 AA3 6 THR B  50  THR B  54  0
SHEET    2 AA3 6 ALA B  63  PRO B  69 -1  O  VAL B  66   N  PHE B  53
SHEET    3 AA3 6 VAL B 105  ASP B 110 -1  O  THR B 108   N  THR B  65
SHEET    4 AA3 6 VAL B  76  VAL B  82  1  N  GLY B  77   O  VAL B 105
SHEET    5 AA3 6 VAL B 147  GLY B 156  1  O  MET B 155   N  ALA B  80
SHEET    6 AA3 6 ALA B 176  ALA B 177  1  O  ALA B 176   N  VAL B 154
SHEET    1 AA4 3 THR B 195  CYS B 200  0
SHEET    2 AA4 3 LYS B 224  ILE B 229  1  O  ALA B 225   N  ILE B 197
SHEET    3 AA4 3 VAL B 283  GLU B 288 -1  O  ALA B 285   N  VAL B 228
SSBOND   1 CYS A  200    CYS A  236                          1555   1555  2.06
SSBOND   2 CYS A  270    CYS A  290                          1555   1555  2.12
SSBOND   3 CYS B  200    CYS B  236                          1555   1555  2.08
SSBOND   4 CYS B  270    CYS B  290                          1555   1555  2.03
CISPEP   1 CYS A  290    PRO A  291          0         3.59
CISPEP   2 CYS B  290    PRO B  291          0        -5.28
CRYST1   69.267   75.512  200.713  90.00  90.00  90.00 C 2 2 21     16
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.014437  0.000000  0.000000        0.00000
SCALE2      0.000000  0.013243  0.000000        0.00000
SCALE3      0.000000  0.000000  0.004982        0.00000
TER    1996      LEU A 293
TER    3992      LEU B 293
MASTER      294    0    0   21   18    0    0    6 4115    2    8   42
END