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HEADER MEMBRANE PROTEIN 01-MAR-21 7E8H
TITLE CRYOEM STRUCTURE OF HUMAN KV4.2-DPP6S-KCHIP1 COMPLEX
COMPND MOL_ID: 1;
COMPND 2 MOLECULE: DIPEPTIDYL AMINOPEPTIDASE-LIKE PROTEIN 6;
COMPND 3 CHAIN: J, L;
COMPND 4 SYNONYM: DPPX,DIPEPTIDYL AMINOPEPTIDASE-RELATED PROTEIN,DIPEPTIDYL
COMPND 5 PEPTIDASE 6,DIPEPTIDYL PEPTIDASE IV-LIKE PROTEIN,DIPEPTIDYL PEPTIDASE
COMPND 6 VI,DPP VI;
COMPND 7 ENGINEERED: YES;
COMPND 8 MOL_ID: 2;
COMPND 9 MOLECULE: DIPEPTIDYL AMINOPEPTIDASE-LIKE PROTEIN 6;
COMPND 10 CHAIN: I, K;
COMPND 11 SYNONYM: DPPX,DIPEPTIDYL AMINOPEPTIDASE-RELATED PROTEIN,DIPEPTIDYL
COMPND 12 PEPTIDASE 6,DIPEPTIDYL PEPTIDASE IV-LIKE PROTEIN,DIPEPTIDYL PEPTIDASE
COMPND 13 VI,DPP VI;
COMPND 14 ENGINEERED: YES;
COMPND 15 MOL_ID: 3;
COMPND 16 MOLECULE: KV CHANNEL-INTERACTING PROTEIN 1;
COMPND 17 CHAIN: F, H;
COMPND 18 SYNONYM: KCHIP1,A-TYPE POTASSIUM CHANNEL MODULATORY PROTEIN 1,
COMPND 19 POTASSIUM CHANNEL-INTERACTING PROTEIN 1,VESICLE APC-BINDING PROTEIN;
COMPND 20 ENGINEERED: YES;
COMPND 21 MOL_ID: 4;
COMPND 22 MOLECULE: POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY D MEMBER 2;
COMPND 23 CHAIN: B, A, D, C;
COMPND 24 SYNONYM: VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT KV4.2;
COMPND 25 ENGINEERED: YES;
COMPND 26 MOL_ID: 5;
COMPND 27 MOLECULE: KV CHANNEL-INTERACTING PROTEIN 1;
COMPND 28 CHAIN: E, G;
COMPND 29 SYNONYM: KCHIP1,A-TYPE POTASSIUM CHANNEL MODULATORY PROTEIN 1,
COMPND 30 POTASSIUM CHANNEL-INTERACTING PROTEIN 1,VESICLE APC-BINDING PROTEIN;
COMPND 31 ENGINEERED: YES
SOURCE MOL_ID: 1;
SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 3 ORGANISM_COMMON: HUMAN;
SOURCE 4 ORGANISM_TAXID: 9606;
SOURCE 5 GENE: DPP6;
SOURCE 6 EXPRESSION_SYSTEM: HOMO SAPIENS;
SOURCE 7 EXPRESSION_SYSTEM_TAXID: 9606;
SOURCE 8 MOL_ID: 2;
SOURCE 9 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 10 ORGANISM_COMMON: HUMAN;
SOURCE 11 ORGANISM_TAXID: 9606;
SOURCE 12 GENE: DPP6;
SOURCE 13 EXPRESSION_SYSTEM: HOMO SAPIENS;
SOURCE 14 EXPRESSION_SYSTEM_TAXID: 9606;
SOURCE 15 MOL_ID: 3;
SOURCE 16 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 17 ORGANISM_COMMON: HUMAN;
SOURCE 18 ORGANISM_TAXID: 9606;
SOURCE 19 GENE: KCNIP1, KCHIP1, VABP;
SOURCE 20 EXPRESSION_SYSTEM: HOMO SAPIENS;
SOURCE 21 EXPRESSION_SYSTEM_TAXID: 9606;
SOURCE 22 MOL_ID: 4;
SOURCE 23 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 24 ORGANISM_COMMON: HUMAN;
SOURCE 25 ORGANISM_TAXID: 9606;
SOURCE 26 GENE: KCND2, KIAA1044;
SOURCE 27 EXPRESSION_SYSTEM: HOMO SAPIENS;
SOURCE 28 EXPRESSION_SYSTEM_TAXID: 9606;
SOURCE 29 MOL_ID: 5;
SOURCE 30 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 31 ORGANISM_COMMON: HUMAN;
SOURCE 32 ORGANISM_TAXID: 9606;
SOURCE 33 GENE: KCNIP1, KCHIP1, VABP;
SOURCE 34 EXPRESSION_SYSTEM: HOMO SAPIENS;
SOURCE 35 EXPRESSION_SYSTEM_TAXID: 9606
KEYWDS MEMBRANE PROTEIN
EXPDTA ELECTRON MICROSCOPY
AUTHOR Y.KISE,O.NUREKI
REVDAT 1 13-OCT-21 7E8H 0
JRNL AUTH Y.KISE,G.KASUYA,H.H.OKAMOTO,D.YAMANOUCHI,K.KOBAYASHI,
JRNL AUTH 2 T.KUSAKIZAKO,T.NISHIZAWA,K.NAKAJO,O.NUREKI
JRNL TITL STRUCTURAL BASIS OF GATING MODULATION OF KV4 CHANNEL
JRNL TITL 2 COMPLEXES.
JRNL REF NATURE 2021
JRNL REFN ESSN 1476-4687
JRNL PMID 34552243
JRNL DOI 10.1038/S41586-021-03935-Z
REMARK 2
REMARK 2 RESOLUTION. 4.50 ANGSTROMS.
REMARK 3
REMARK 3 REFINEMENT.
REMARK 3 SOFTWARE PACKAGES : NULL
REMARK 3 RECONSTRUCTION SCHEMA : NULL
REMARK 3
REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT
REMARK 3 PDB ENTRY : NULL
REMARK 3 REFINEMENT SPACE : NULL
REMARK 3 REFINEMENT PROTOCOL : NULL
REMARK 3 REFINEMENT TARGET : NULL
REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL
REMARK 3
REMARK 3 FITTING PROCEDURE : NULL
REMARK 3
REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS
REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 4.500
REMARK 3 NUMBER OF PARTICLES : 139524
REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE
REMARK 3 CORRECTION
REMARK 3
REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL
REMARK 3
REMARK 3 OTHER DETAILS: NULL
REMARK 4
REMARK 4 7E8H COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 02-MAR-21.
REMARK 100 THE DEPOSITION ID IS D_1300020969.
REMARK 245
REMARK 245 EXPERIMENTAL DETAILS
REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE
REMARK 245 SPECIMEN TYPE : NULL
REMARK 245
REMARK 245 ELECTRON MICROSCOPE SAMPLE
REMARK 245 SAMPLE TYPE : PARTICLE
REMARK 245 PARTICLE TYPE : POINT
REMARK 245 NAME OF SAMPLE : HUMAN KV4.2-DPP6S-KCHIP1
REMARK 245 COMPLEX
REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL
REMARK 245 SAMPLE SUPPORT DETAILS : NULL
REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL
REMARK 245 SAMPLE BUFFER : NULL
REMARK 245 PH : 8.00
REMARK 245 SAMPLE DETAILS : NULL
REMARK 245
REMARK 245 DATA ACQUISITION
REMARK 245 DATE OF EXPERIMENT : NULL
REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL
REMARK 245 TEMPERATURE (KELVIN) : NULL
REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS
REMARK 245 DETECTOR TYPE : GATAN K3 BIOQUANTUM (6K X
REMARK 245 4K)
REMARK 245 MINIMUM DEFOCUS (NM) : NULL
REMARK 245 MAXIMUM DEFOCUS (NM) : NULL
REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 NOMINAL CS : NULL
REMARK 245 IMAGING MODE : BRIGHT FIELD
REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 4800.00
REMARK 245 ILLUMINATION MODE : FLOOD BEAM
REMARK 245 NOMINAL MAGNIFICATION : NULL
REMARK 245 CALIBRATED MAGNIFICATION : NULL
REMARK 245 SOURCE : FIELD EMISSION GUN
REMARK 245 ACCELERATION VOLTAGE (KV) : 300
REMARK 245 IMAGING DETAILS : NULL
REMARK 247
REMARK 247 ELECTRON MICROSCOPY
REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON
REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE
REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES
REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION
REMARK 247 OF THE STRUCTURE FACTORS.
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DODECAMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: J, I, F, B, E, A, L, K, H, D,
REMARK 350 AND CHAINS: G, C
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465 M RES C SSSEQI
REMARK 465 PRO J 302
REMARK 465 ASP F 187
REMARK 465 GLY F 188
REMARK 465 ILE F 189
REMARK 465 VAL F 190
REMARK 465 GLY B 158
REMARK 465 GLU B 159
REMARK 465 SER B 160
REMARK 465 ALA B 161
REMARK 465 LEU B 162
REMARK 465 PRO B 163
REMARK 465 THR B 164
REMARK 465 MET B 165
REMARK 465 THR B 166
REMARK 465 LEU B 219
REMARK 465 PRO B 220
REMARK 465 CYS B 221
REMARK 465 GLY B 222
REMARK 465 GLU B 223
REMARK 465 GLY B 451
REMARK 465 LEU B 452
REMARK 465 LEU B 453
REMARK 465 SER B 454
REMARK 465 ASN B 455
REMARK 465 GLN B 456
REMARK 465 LEU B 457
REMARK 465 GLN B 458
REMARK 465 SER B 459
REMARK 465 SER B 460
REMARK 465 GLU B 461
REMARK 465 ASP B 462
REMARK 465 GLU B 463
REMARK 465 GLN B 464
REMARK 465 ALA B 465
REMARK 465 PHE B 466
REMARK 465 VAL B 467
REMARK 465 SER B 468
REMARK 465 LYS B 469
REMARK 465 SER B 470
REMARK 465 GLY B 471
REMARK 465 ASP E 187
REMARK 465 GLY E 188
REMARK 465 ILE E 189
REMARK 465 VAL E 190
REMARK 465 GLY A 158
REMARK 465 GLU A 159
REMARK 465 SER A 160
REMARK 465 ALA A 161
REMARK 465 LEU A 162
REMARK 465 PRO A 163
REMARK 465 THR A 164
REMARK 465 MET A 165
REMARK 465 THR A 166
REMARK 465 PRO A 220
REMARK 465 CYS A 221
REMARK 465 GLY A 222
REMARK 465 GLU A 223
REMARK 465 GLY A 451
REMARK 465 LEU A 452
REMARK 465 LEU A 453
REMARK 465 SER A 454
REMARK 465 ASN A 455
REMARK 465 GLN A 456
REMARK 465 LEU A 457
REMARK 465 GLN A 458
REMARK 465 SER A 459
REMARK 465 SER A 460
REMARK 465 GLU A 461
REMARK 465 ASP A 462
REMARK 465 GLU A 463
REMARK 465 GLN A 464
REMARK 465 ALA A 465
REMARK 465 PHE A 466
REMARK 465 VAL A 467
REMARK 465 SER A 468
REMARK 465 LYS A 469
REMARK 465 SER A 470
REMARK 465 GLY A 471
REMARK 465 PRO L 302
REMARK 465 ASP H 187
REMARK 465 GLY H 188
REMARK 465 ILE H 189
REMARK 465 VAL H 190
REMARK 465 GLY D 158
REMARK 465 GLU D 159
REMARK 465 SER D 160
REMARK 465 ALA D 161
REMARK 465 LEU D 162
REMARK 465 PRO D 163
REMARK 465 THR D 164
REMARK 465 MET D 165
REMARK 465 THR D 166
REMARK 465 LEU D 219
REMARK 465 PRO D 220
REMARK 465 CYS D 221
REMARK 465 GLY D 222
REMARK 465 GLU D 223
REMARK 465 GLY D 451
REMARK 465 LEU D 452
REMARK 465 LEU D 453
REMARK 465 SER D 454
REMARK 465 ASN D 455
REMARK 465 GLN D 456
REMARK 465 LEU D 457
REMARK 465 GLN D 458
REMARK 465 SER D 459
REMARK 465 SER D 460
REMARK 465 GLU D 461
REMARK 465 ASP D 462
REMARK 465 GLU D 463
REMARK 465 GLN D 464
REMARK 465 ALA D 465
REMARK 465 PHE D 466
REMARK 465 VAL D 467
REMARK 465 SER D 468
REMARK 465 LYS D 469
REMARK 465 SER D 470
REMARK 465 GLY D 471
REMARK 465 ASP G 187
REMARK 465 GLY G 188
REMARK 465 ILE G 189
REMARK 465 VAL G 190
REMARK 465 GLY C 158
REMARK 465 GLU C 159
REMARK 465 SER C 160
REMARK 465 ALA C 161
REMARK 465 LEU C 162
REMARK 465 PRO C 163
REMARK 465 THR C 164
REMARK 465 MET C 165
REMARK 465 THR C 166
REMARK 465 PRO C 220
REMARK 465 CYS C 221
REMARK 465 GLY C 222
REMARK 465 GLU C 223
REMARK 465 GLY C 451
REMARK 465 LEU C 452
REMARK 465 LEU C 453
REMARK 465 SER C 454
REMARK 465 ASN C 455
REMARK 465 GLN C 456
REMARK 465 LEU C 457
REMARK 465 GLN C 458
REMARK 465 SER C 459
REMARK 465 SER C 460
REMARK 465 GLU C 461
REMARK 465 ASP C 462
REMARK 465 GLU C 463
REMARK 465 GLN C 464
REMARK 465 ALA C 465
REMARK 465 PHE C 466
REMARK 465 VAL C 467
REMARK 465 SER C 468
REMARK 465 LYS C 469
REMARK 465 SER C 470
REMARK 465 GLY C 471
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE
REMARK 500 OH TYR K 654 O THR K 708 2.09
REMARK 500 OH TYR I 654 O THR I 708 2.09
REMARK 500 O HIS E 92 ND2 ASN E 96 2.10
REMARK 500 O MET B 238 OG1 THR B 241 2.11
REMARK 500 O MET D 238 OG1 THR D 241 2.12
REMARK 500 O LYS G 167 OG1 THR G 170 2.16
REMARK 500 O LEU C 277 OG1 THR C 280 2.16
REMARK 500 O LEU A 277 OG1 THR A 280 2.16
REMARK 500 O LYS E 167 OG1 THR E 170 2.16
REMARK 500 OG SER L 160 O GLY L 165 2.17
REMARK 500 OG SER J 160 O GLY J 165 2.17
REMARK 500 OD1 ASN I 289 OG SER I 688 2.19
REMARK 500 OD1 ASN K 289 OG SER K 688 2.19
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500 M RES CSSEQI PSI PHI
REMARK 500 GLU J 85 48.68 38.54
REMARK 500 ARG J 97 -175.20 -69.57
REMARK 500 ASN J 111 47.37 33.71
REMARK 500 GLU J 118 -166.24 -123.80
REMARK 500 ALA J 366 -63.49 -94.66
REMARK 500 TRP J 367 -178.87 -170.74
REMARK 500 LYS J 383 130.44 -36.85
REMARK 500 GLN J 392 19.81 56.68
REMARK 500 ILE J 418 -62.21 -90.25
REMARK 500 CYS J 468 -95.90 54.87
REMARK 500 MET J 485 -5.96 73.64
REMARK 500 ASP J 540 -124.17 55.47
REMARK 500 GLU J 577 32.85 -96.95
REMARK 500 TYR J 638 1.10 -69.64
REMARK 500 ASP J 650 -132.55 57.57
REMARK 500 LEU J 660 71.87 -110.42
REMARK 500 GLN J 667 53.78 -90.33
REMARK 500 ARG J 703 -0.66 70.00
REMARK 500 ALA J 716 -70.74 -65.34
REMARK 500 LEU J 717 59.76 36.49
REMARK 500 ALA J 729 36.62 -99.07
REMARK 500 ASP J 759 60.42 64.84
REMARK 500 HIS I 82 54.26 -92.61
REMARK 500 ASN I 111 46.79 34.20
REMARK 500 ARG I 136 48.14 39.48
REMARK 500 PRO I 147 -176.93 -68.71
REMARK 500 TYR I 149 -65.13 -96.52
REMARK 500 GLN I 150 -52.83 -123.28
REMARK 500 THR I 154 -164.21 -78.88
REMARK 500 HIS I 164 173.96 179.65
REMARK 500 ASP I 166 72.31 51.94
REMARK 500 GLU I 174 28.69 46.10
REMARK 500 SER I 215 15.06 -140.86
REMARK 500 ASN I 224 117.22 -160.08
REMARK 500 ILE I 235 -53.33 -124.27
REMARK 500 LYS I 237 9.89 59.12
REMARK 500 ALA I 366 -61.96 -95.18
REMARK 500 ASN I 414 30.88 -97.59
REMARK 500 THR I 443 31.19 -93.67
REMARK 500 LEU I 466 -51.59 -120.08
REMARK 500 SER I 467 -62.80 -103.81
REMARK 500 CYS I 468 60.95 35.98
REMARK 500 SER I 482 -169.62 -77.66
REMARK 500 GLU I 493 27.53 49.24
REMARK 500 ASP I 540 -133.13 59.01
REMARK 500 ASP I 541 31.15 -98.97
REMARK 500 ALA I 552 -4.70 68.59
REMARK 500 ARG I 616 9.59 59.82
REMARK 500 ASP I 650 -133.36 55.92
REMARK 500 LEU I 660 78.86 -109.99
REMARK 500
REMARK 500 THIS ENTRY HAS 171 RAMACHANDRAN OUTLIERS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: EMD-31019 RELATED DB: EMDB
REMARK 900 MEMBRANE PROTEIN
DBREF 7E8H J 32 787 UNP P42658 DPP6_HUMAN 94 849
DBREF 7E8H I 32 787 UNP P42658 DPP6_HUMAN 94 849
DBREF 7E8H F 37 216 UNP Q9NZI2 KCIP1_HUMAN 48 227
DBREF 7E8H B 2 495 UNP Q9NZV8 KCND2_HUMAN 2 495
DBREF 7E8H E 36 216 UNP Q9NZI2 KCIP1_HUMAN 47 227
DBREF 7E8H A 2 495 UNP Q9NZV8 KCND2_HUMAN 2 495
DBREF 7E8H L 32 787 UNP P42658 DPP6_HUMAN 94 849
DBREF 7E8H K 32 787 UNP P42658 DPP6_HUMAN 94 849
DBREF 7E8H H 37 216 UNP Q9NZI2 KCIP1_HUMAN 48 227
DBREF 7E8H D 2 495 UNP Q9NZV8 KCND2_HUMAN 2 495
DBREF 7E8H G 36 216 UNP Q9NZI2 KCIP1_HUMAN 47 227
DBREF 7E8H C 2 495 UNP Q9NZV8 KCND2_HUMAN 2 495
SEQADV 7E8H ALA J 31 UNP P42658 EXPRESSION TAG
SEQADV 7E8H ALA I 28 UNP P42658 EXPRESSION TAG
SEQADV 7E8H ALA I 29 UNP P42658 EXPRESSION TAG
SEQADV 7E8H ALA I 30 UNP P42658 EXPRESSION TAG
SEQADV 7E8H ALA I 31 UNP P42658 EXPRESSION TAG
SEQADV 7E8H SER B 450 UNP Q9NZV8 ASN 450 CONFLICT
SEQADV 7E8H SER A 450 UNP Q9NZV8 ASN 450 CONFLICT
SEQADV 7E8H ALA L 31 UNP P42658 EXPRESSION TAG
SEQADV 7E8H ALA K 28 UNP P42658 EXPRESSION TAG
SEQADV 7E8H ALA K 29 UNP P42658 EXPRESSION TAG
SEQADV 7E8H ALA K 30 UNP P42658 EXPRESSION TAG
SEQADV 7E8H ALA K 31 UNP P42658 EXPRESSION TAG
SEQADV 7E8H SER D 450 UNP Q9NZV8 ASN 450 CONFLICT
SEQADV 7E8H SER C 450 UNP Q9NZV8 ASN 450 CONFLICT
SEQRES 1 J 757 ALA LYS GLY ILE ALA ILE ALA LEU LEU VAL ILE LEU VAL
SEQRES 2 J 757 ILE CYS SER LEU ILE VAL THR SER VAL ILE LEU LEU THR
SEQRES 3 J 757 PRO ALA GLU ASP ASN SER LEU SER GLN LYS LYS LYS VAL
SEQRES 4 J 757 THR VAL GLU ASP LEU PHE SER GLU ASP PHE LYS ILE HIS
SEQRES 5 J 757 ASP PRO GLU ALA LYS TRP ILE SER ASP THR GLU PHE ILE
SEQRES 6 J 757 TYR ARG GLU GLN LYS GLY THR VAL ARG LEU TRP ASN VAL
SEQRES 7 J 757 GLU THR ASN THR SER THR VAL LEU ILE GLU GLY LYS LYS
SEQRES 8 J 757 ILE GLU SER LEU ARG ALA ILE ARG TYR GLU ILE SER PRO
SEQRES 9 J 757 ASP ARG GLU TYR ALA LEU PHE SER TYR ASN VAL GLU PRO
SEQRES 10 J 757 ILE TYR GLN HIS SER TYR THR GLY TYR TYR VAL LEU SER
SEQRES 11 J 757 LYS ILE PRO HIS GLY ASP PRO GLN SER LEU ASP PRO PRO
SEQRES 12 J 757 GLU VAL SER ASN ALA LYS LEU GLN TYR ALA GLY TRP GLY
SEQRES 13 J 757 PRO LYS GLY GLN GLN LEU ILE PHE ILE PHE GLU ASN ASN
SEQRES 14 J 757 ILE TYR TYR CYS ALA HIS VAL GLY LYS GLN ALA ILE ARG
SEQRES 15 J 757 VAL VAL SER THR GLY LYS GLU GLY VAL ILE TYR ASN GLY
SEQRES 16 J 757 LEU SER ASP TRP LEU TYR GLU GLU GLU ILE LEU LYS THR
SEQRES 17 J 757 HIS ILE ALA HIS TRP TRP SER PRO ASP GLY THR ARG LEU
SEQRES 18 J 757 ALA TYR ALA ALA ILE ASN ASP SER ARG VAL PRO ILE MET
SEQRES 19 J 757 GLU LEU PRO THR TYR THR GLY SER ILE TYR PRO THR VAL
SEQRES 20 J 757 LYS PRO TYR HIS TYR PRO LYS ALA GLY SER GLU ASN PRO
SEQRES 21 J 757 SER ILE SER LEU HIS VAL ILE GLY LEU ASN GLY PRO THR
SEQRES 22 J 757 HIS ASP LEU GLU MET MET PRO PRO ASP ASP PRO ARG MET
SEQRES 23 J 757 ARG GLU TYR TYR ILE THR MET VAL LYS TRP ALA THR SER
SEQRES 24 J 757 THR LYS VAL ALA VAL THR TRP LEU ASN ARG ALA GLN ASN
SEQRES 25 J 757 VAL SER ILE LEU THR LEU CYS ASP ALA THR THR GLY VAL
SEQRES 26 J 757 CYS THR LYS LYS HIS GLU ASP GLU SER GLU ALA TRP LEU
SEQRES 27 J 757 HIS ARG GLN ASN GLU GLU PRO VAL PHE SER LYS ASP GLY
SEQRES 28 J 757 ARG LYS PHE PHE PHE ILE ARG ALA ILE PRO GLN GLY GLY
SEQRES 29 J 757 ARG GLY LYS PHE TYR HIS ILE THR VAL SER SER SER GLN
SEQRES 30 J 757 PRO ASN SER SER ASN ASP ASN ILE GLN SER ILE THR SER
SEQRES 31 J 757 GLY ASP TRP ASP VAL THR LYS ILE LEU ALA TYR ASP GLU
SEQRES 32 J 757 LYS GLY ASN LYS ILE TYR PHE LEU SER THR GLU ASP LEU
SEQRES 33 J 757 PRO ARG ARG ARG GLN LEU TYR SER ALA ASN THR VAL GLY
SEQRES 34 J 757 ASN PHE ASN ARG GLN CYS LEU SER CYS ASP LEU VAL GLU
SEQRES 35 J 757 ASN CYS THR TYR PHE SER ALA SER PHE SER HIS SER MET
SEQRES 36 J 757 ASP PHE PHE LEU LEU LYS CYS GLU GLY PRO GLY VAL PRO
SEQRES 37 J 757 MET VAL THR VAL HIS ASN THR THR ASP LYS LYS LYS MET
SEQRES 38 J 757 PHE ASP LEU GLU THR ASN GLU HIS VAL LYS LYS ALA ILE
SEQRES 39 J 757 ASN ASP ARG GLN MET PRO LYS VAL GLU TYR ARG ASP ILE
SEQRES 40 J 757 GLU ILE ASP ASP TYR ASN LEU PRO MET GLN ILE LEU LYS
SEQRES 41 J 757 PRO ALA THR PHE THR ASP THR THR HIS TYR PRO LEU LEU
SEQRES 42 J 757 LEU VAL VAL ASP GLY THR PRO GLY SER GLN SER VAL ALA
SEQRES 43 J 757 GLU LYS PHE GLU VAL SER TRP GLU THR VAL MET VAL SER
SEQRES 44 J 757 SER HIS GLY ALA VAL VAL VAL LYS CYS ASP GLY ARG GLY
SEQRES 45 J 757 SER GLY PHE GLN GLY THR LYS LEU LEU HIS GLU VAL ARG
SEQRES 46 J 757 ARG ARG LEU GLY LEU LEU GLU GLU LYS ASP GLN MET GLU
SEQRES 47 J 757 ALA VAL ARG THR MET LEU LYS GLU GLN TYR ILE ASP ARG
SEQRES 48 J 757 THR ARG VAL ALA VAL PHE GLY LYS ASP TYR GLY GLY TYR
SEQRES 49 J 757 LEU SER THR TYR ILE LEU PRO ALA LYS GLY GLU ASN GLN
SEQRES 50 J 757 GLY GLN THR PHE THR CYS GLY SER ALA LEU SER PRO ILE
SEQRES 51 J 757 THR ASP PHE LYS LEU TYR ALA SER ALA PHE SER GLU ARG
SEQRES 52 J 757 TYR LEU GLY LEU HIS GLY LEU ASP ASN ARG ALA TYR GLU
SEQRES 53 J 757 MET THR LYS VAL ALA HIS ARG VAL SER ALA LEU GLU GLU
SEQRES 54 J 757 GLN GLN PHE LEU ILE ILE HIS PRO THR ALA ASP GLU LYS
SEQRES 55 J 757 ILE HIS PHE GLN HIS THR ALA GLU LEU ILE THR GLN LEU
SEQRES 56 J 757 ILE ARG GLY LYS ALA ASN TYR SER LEU GLN ILE TYR PRO
SEQRES 57 J 757 ASP GLU SER HIS TYR PHE THR SER SER SER LEU LYS GLN
SEQRES 58 J 757 HIS LEU TYR ARG SER ILE ILE ASN PHE PHE VAL GLU CYS
SEQRES 59 J 757 PHE ARG ILE
SEQRES 1 I 760 ALA ALA ALA ALA LYS GLY ILE ALA ILE ALA LEU LEU VAL
SEQRES 2 I 760 ILE LEU VAL ILE CYS SER LEU ILE VAL THR SER VAL ILE
SEQRES 3 I 760 LEU LEU THR PRO ALA GLU ASP ASN SER LEU SER GLN LYS
SEQRES 4 I 760 LYS LYS VAL THR VAL GLU ASP LEU PHE SER GLU ASP PHE
SEQRES 5 I 760 LYS ILE HIS ASP PRO GLU ALA LYS TRP ILE SER ASP THR
SEQRES 6 I 760 GLU PHE ILE TYR ARG GLU GLN LYS GLY THR VAL ARG LEU
SEQRES 7 I 760 TRP ASN VAL GLU THR ASN THR SER THR VAL LEU ILE GLU
SEQRES 8 I 760 GLY LYS LYS ILE GLU SER LEU ARG ALA ILE ARG TYR GLU
SEQRES 9 I 760 ILE SER PRO ASP ARG GLU TYR ALA LEU PHE SER TYR ASN
SEQRES 10 I 760 VAL GLU PRO ILE TYR GLN HIS SER TYR THR GLY TYR TYR
SEQRES 11 I 760 VAL LEU SER LYS ILE PRO HIS GLY ASP PRO GLN SER LEU
SEQRES 12 I 760 ASP PRO PRO GLU VAL SER ASN ALA LYS LEU GLN TYR ALA
SEQRES 13 I 760 GLY TRP GLY PRO LYS GLY GLN GLN LEU ILE PHE ILE PHE
SEQRES 14 I 760 GLU ASN ASN ILE TYR TYR CYS ALA HIS VAL GLY LYS GLN
SEQRES 15 I 760 ALA ILE ARG VAL VAL SER THR GLY LYS GLU GLY VAL ILE
SEQRES 16 I 760 TYR ASN GLY LEU SER ASP TRP LEU TYR GLU GLU GLU ILE
SEQRES 17 I 760 LEU LYS THR HIS ILE ALA HIS TRP TRP SER PRO ASP GLY
SEQRES 18 I 760 THR ARG LEU ALA TYR ALA ALA ILE ASN ASP SER ARG VAL
SEQRES 19 I 760 PRO ILE MET GLU LEU PRO THR TYR THR GLY SER ILE TYR
SEQRES 20 I 760 PRO THR VAL LYS PRO TYR HIS TYR PRO LYS ALA GLY SER
SEQRES 21 I 760 GLU ASN PRO SER ILE SER LEU HIS VAL ILE GLY LEU ASN
SEQRES 22 I 760 GLY PRO THR HIS ASP LEU GLU MET MET PRO PRO ASP ASP
SEQRES 23 I 760 PRO ARG MET ARG GLU TYR TYR ILE THR MET VAL LYS TRP
SEQRES 24 I 760 ALA THR SER THR LYS VAL ALA VAL THR TRP LEU ASN ARG
SEQRES 25 I 760 ALA GLN ASN VAL SER ILE LEU THR LEU CYS ASP ALA THR
SEQRES 26 I 760 THR GLY VAL CYS THR LYS LYS HIS GLU ASP GLU SER GLU
SEQRES 27 I 760 ALA TRP LEU HIS ARG GLN ASN GLU GLU PRO VAL PHE SER
SEQRES 28 I 760 LYS ASP GLY ARG LYS PHE PHE PHE ILE ARG ALA ILE PRO
SEQRES 29 I 760 GLN GLY GLY ARG GLY LYS PHE TYR HIS ILE THR VAL SER
SEQRES 30 I 760 SER SER GLN PRO ASN SER SER ASN ASP ASN ILE GLN SER
SEQRES 31 I 760 ILE THR SER GLY ASP TRP ASP VAL THR LYS ILE LEU ALA
SEQRES 32 I 760 TYR ASP GLU LYS GLY ASN LYS ILE TYR PHE LEU SER THR
SEQRES 33 I 760 GLU ASP LEU PRO ARG ARG ARG GLN LEU TYR SER ALA ASN
SEQRES 34 I 760 THR VAL GLY ASN PHE ASN ARG GLN CYS LEU SER CYS ASP
SEQRES 35 I 760 LEU VAL GLU ASN CYS THR TYR PHE SER ALA SER PHE SER
SEQRES 36 I 760 HIS SER MET ASP PHE PHE LEU LEU LYS CYS GLU GLY PRO
SEQRES 37 I 760 GLY VAL PRO MET VAL THR VAL HIS ASN THR THR ASP LYS
SEQRES 38 I 760 LYS LYS MET PHE ASP LEU GLU THR ASN GLU HIS VAL LYS
SEQRES 39 I 760 LYS ALA ILE ASN ASP ARG GLN MET PRO LYS VAL GLU TYR
SEQRES 40 I 760 ARG ASP ILE GLU ILE ASP ASP TYR ASN LEU PRO MET GLN
SEQRES 41 I 760 ILE LEU LYS PRO ALA THR PHE THR ASP THR THR HIS TYR
SEQRES 42 I 760 PRO LEU LEU LEU VAL VAL ASP GLY THR PRO GLY SER GLN
SEQRES 43 I 760 SER VAL ALA GLU LYS PHE GLU VAL SER TRP GLU THR VAL
SEQRES 44 I 760 MET VAL SER SER HIS GLY ALA VAL VAL VAL LYS CYS ASP
SEQRES 45 I 760 GLY ARG GLY SER GLY PHE GLN GLY THR LYS LEU LEU HIS
SEQRES 46 I 760 GLU VAL ARG ARG ARG LEU GLY LEU LEU GLU GLU LYS ASP
SEQRES 47 I 760 GLN MET GLU ALA VAL ARG THR MET LEU LYS GLU GLN TYR
SEQRES 48 I 760 ILE ASP ARG THR ARG VAL ALA VAL PHE GLY LYS ASP TYR
SEQRES 49 I 760 GLY GLY TYR LEU SER THR TYR ILE LEU PRO ALA LYS GLY
SEQRES 50 I 760 GLU ASN GLN GLY GLN THR PHE THR CYS GLY SER ALA LEU
SEQRES 51 I 760 SER PRO ILE THR ASP PHE LYS LEU TYR ALA SER ALA PHE
SEQRES 52 I 760 SER GLU ARG TYR LEU GLY LEU HIS GLY LEU ASP ASN ARG
SEQRES 53 I 760 ALA TYR GLU MET THR LYS VAL ALA HIS ARG VAL SER ALA
SEQRES 54 I 760 LEU GLU GLU GLN GLN PHE LEU ILE ILE HIS PRO THR ALA
SEQRES 55 I 760 ASP GLU LYS ILE HIS PHE GLN HIS THR ALA GLU LEU ILE
SEQRES 56 I 760 THR GLN LEU ILE ARG GLY LYS ALA ASN TYR SER LEU GLN
SEQRES 57 I 760 ILE TYR PRO ASP GLU SER HIS TYR PHE THR SER SER SER
SEQRES 58 I 760 LEU LYS GLN HIS LEU TYR ARG SER ILE ILE ASN PHE PHE
SEQRES 59 I 760 VAL GLU CYS PHE ARG ILE
SEQRES 1 F 180 GLU GLY LEU GLU GLN LEU GLU ALA GLN THR ASN PHE THR
SEQRES 2 F 180 LYS ARG GLU LEU GLN VAL LEU TYR ARG GLY PHE LYS ASN
SEQRES 3 F 180 GLU CYS PRO SER GLY VAL VAL ASN GLU ASP THR PHE LYS
SEQRES 4 F 180 GLN ILE TYR ALA GLN PHE PHE PRO HIS GLY ASP ALA SER
SEQRES 5 F 180 THR TYR ALA HIS TYR LEU PHE ASN ALA PHE ASP THR THR
SEQRES 6 F 180 GLN THR GLY SER VAL LYS PHE GLU ASP PHE VAL THR ALA
SEQRES 7 F 180 LEU SER ILE LEU LEU ARG GLY THR VAL HIS GLU LYS LEU
SEQRES 8 F 180 ARG TRP THR PHE ASN LEU TYR ASP ILE ASN LYS ASP GLY
SEQRES 9 F 180 TYR ILE ASN LYS GLU GLU MET MET ASP ILE VAL LYS ALA
SEQRES 10 F 180 ILE TYR ASP MET MET GLY LYS TYR THR TYR PRO VAL LEU
SEQRES 11 F 180 LYS GLU ASP THR PRO ARG GLN HIS VAL ASP VAL PHE PHE
SEQRES 12 F 180 GLN LYS MET ASP LYS ASN LYS ASP GLY ILE VAL THR LEU
SEQRES 13 F 180 ASP GLU PHE LEU GLU SER CYS GLN GLU ASP ASP ASN ILE
SEQRES 14 F 180 MET ARG SER LEU GLN LEU PHE GLN ASN VAL MET
SEQRES 1 B 494 ALA ALA GLY VAL ALA ALA TRP LEU PRO PHE ALA ARG ALA
SEQRES 2 B 494 ALA ALA ILE GLY TRP MET PRO VAL ALA SER GLY PRO MET
SEQRES 3 B 494 PRO ALA PRO PRO ARG GLN GLU ARG LYS ARG THR GLN ASP
SEQRES 4 B 494 ALA LEU ILE VAL LEU ASN VAL SER GLY THR ARG PHE GLN
SEQRES 5 B 494 THR TRP GLN ASP THR LEU GLU ARG TYR PRO ASP THR LEU
SEQRES 6 B 494 LEU GLY SER SER GLU ARG ASP PHE PHE TYR HIS PRO GLU
SEQRES 7 B 494 THR GLN GLN TYR PHE PHE ASP ARG ASP PRO ASP ILE PHE
SEQRES 8 B 494 ARG HIS ILE LEU ASN PHE TYR ARG THR GLY LYS LEU HIS
SEQRES 9 B 494 TYR PRO ARG HIS GLU CYS ILE SER ALA TYR ASP GLU GLU
SEQRES 10 B 494 LEU ALA PHE PHE GLY LEU ILE PRO GLU ILE ILE GLY ASP
SEQRES 11 B 494 CYS CYS TYR GLU GLU TYR LYS ASP ARG ARG ARG GLU ASN
SEQRES 12 B 494 ALA GLU ARG LEU GLN ASP ASP ALA ASP THR ASP THR ALA
SEQRES 13 B 494 GLY GLU SER ALA LEU PRO THR MET THR ALA ARG GLN ARG
SEQRES 14 B 494 VAL TRP ARG ALA PHE GLU ASN PRO HIS THR SER THR MET
SEQRES 15 B 494 ALA LEU VAL PHE TYR TYR VAL THR GLY PHE PHE ILE ALA
SEQRES 16 B 494 VAL SER VAL ILE ALA ASN VAL VAL GLU THR VAL PRO CYS
SEQRES 17 B 494 GLY SER SER PRO GLY HIS ILE LYS GLU LEU PRO CYS GLY
SEQRES 18 B 494 GLU ARG TYR ALA VAL ALA PHE PHE CYS LEU ASP THR ALA
SEQRES 19 B 494 CYS VAL MET ILE PHE THR VAL GLU TYR LEU LEU ARG LEU
SEQRES 20 B 494 ALA ALA ALA PRO SER ARG TYR ARG PHE VAL ARG SER VAL
SEQRES 21 B 494 MET SER ILE ILE ASP VAL VAL ALA ILE LEU PRO TYR TYR
SEQRES 22 B 494 ILE GLY LEU VAL MET THR ASP ASN GLU ASP VAL SER GLY
SEQRES 23 B 494 ALA PHE VAL THR LEU ARG VAL PHE ARG VAL PHE ARG ILE
SEQRES 24 B 494 PHE LYS PHE SER ARG HIS SER GLN GLY LEU ARG ILE LEU
SEQRES 25 B 494 GLY TYR THR LEU LYS SER CYS ALA SER GLU LEU GLY PHE
SEQRES 26 B 494 LEU LEU PHE SER LEU THR MET ALA ILE ILE ILE PHE ALA
SEQRES 27 B 494 THR VAL MET PHE TYR ALA GLU LYS GLY SER SER ALA SER
SEQRES 28 B 494 LYS PHE THR SER ILE PRO ALA ALA PHE TRP TYR THR ILE
SEQRES 29 B 494 VAL THR MET THR THR LEU GLY TYR GLY ASP MET VAL PRO
SEQRES 30 B 494 LYS THR ILE ALA GLY LYS ILE PHE GLY SER ILE CYS SER
SEQRES 31 B 494 LEU SER GLY VAL LEU VAL ILE ALA LEU PRO VAL PRO VAL
SEQRES 32 B 494 ILE VAL SER ASN PHE SER ARG ILE TYR HIS GLN ASN GLN
SEQRES 33 B 494 ARG ALA ASP LYS ARG ARG ALA GLN LYS LYS ALA ARG LEU
SEQRES 34 B 494 ALA ARG ILE ARG ALA ALA LYS SER GLY SER ALA ASN ALA
SEQRES 35 B 494 TYR MET GLN SER LYS ARG SER GLY LEU LEU SER ASN GLN
SEQRES 36 B 494 LEU GLN SER SER GLU ASP GLU GLN ALA PHE VAL SER LYS
SEQRES 37 B 494 SER GLY SER SER PHE GLU THR GLN HIS HIS HIS LEU LEU
SEQRES 38 B 494 HIS CYS LEU GLU LYS THR THR ASN HIS GLU PHE VAL ASP
SEQRES 1 E 181 PRO GLU GLY LEU GLU GLN LEU GLU ALA GLN THR ASN PHE
SEQRES 2 E 181 THR LYS ARG GLU LEU GLN VAL LEU TYR ARG GLY PHE LYS
SEQRES 3 E 181 ASN GLU CYS PRO SER GLY VAL VAL ASN GLU ASP THR PHE
SEQRES 4 E 181 LYS GLN ILE TYR ALA GLN PHE PHE PRO HIS GLY ASP ALA
SEQRES 5 E 181 SER THR TYR ALA HIS TYR LEU PHE ASN ALA PHE ASP THR
SEQRES 6 E 181 THR GLN THR GLY SER VAL LYS PHE GLU ASP PHE VAL THR
SEQRES 7 E 181 ALA LEU SER ILE LEU LEU ARG GLY THR VAL HIS GLU LYS
SEQRES 8 E 181 LEU ARG TRP THR PHE ASN LEU TYR ASP ILE ASN LYS ASP
SEQRES 9 E 181 GLY TYR ILE ASN LYS GLU GLU MET MET ASP ILE VAL LYS
SEQRES 10 E 181 ALA ILE TYR ASP MET MET GLY LYS TYR THR TYR PRO VAL
SEQRES 11 E 181 LEU LYS GLU ASP THR PRO ARG GLN HIS VAL ASP VAL PHE
SEQRES 12 E 181 PHE GLN LYS MET ASP LYS ASN LYS ASP GLY ILE VAL THR
SEQRES 13 E 181 LEU ASP GLU PHE LEU GLU SER CYS GLN GLU ASP ASP ASN
SEQRES 14 E 181 ILE MET ARG SER LEU GLN LEU PHE GLN ASN VAL MET
SEQRES 1 A 494 ALA ALA GLY VAL ALA ALA TRP LEU PRO PHE ALA ARG ALA
SEQRES 2 A 494 ALA ALA ILE GLY TRP MET PRO VAL ALA SER GLY PRO MET
SEQRES 3 A 494 PRO ALA PRO PRO ARG GLN GLU ARG LYS ARG THR GLN ASP
SEQRES 4 A 494 ALA LEU ILE VAL LEU ASN VAL SER GLY THR ARG PHE GLN
SEQRES 5 A 494 THR TRP GLN ASP THR LEU GLU ARG TYR PRO ASP THR LEU
SEQRES 6 A 494 LEU GLY SER SER GLU ARG ASP PHE PHE TYR HIS PRO GLU
SEQRES 7 A 494 THR GLN GLN TYR PHE PHE ASP ARG ASP PRO ASP ILE PHE
SEQRES 8 A 494 ARG HIS ILE LEU ASN PHE TYR ARG THR GLY LYS LEU HIS
SEQRES 9 A 494 TYR PRO ARG HIS GLU CYS ILE SER ALA TYR ASP GLU GLU
SEQRES 10 A 494 LEU ALA PHE PHE GLY LEU ILE PRO GLU ILE ILE GLY ASP
SEQRES 11 A 494 CYS CYS TYR GLU GLU TYR LYS ASP ARG ARG ARG GLU ASN
SEQRES 12 A 494 ALA GLU ARG LEU GLN ASP ASP ALA ASP THR ASP THR ALA
SEQRES 13 A 494 GLY GLU SER ALA LEU PRO THR MET THR ALA ARG GLN ARG
SEQRES 14 A 494 VAL TRP ARG ALA PHE GLU ASN PRO HIS THR SER THR MET
SEQRES 15 A 494 ALA LEU VAL PHE TYR TYR VAL THR GLY PHE PHE ILE ALA
SEQRES 16 A 494 VAL SER VAL ILE ALA ASN VAL VAL GLU THR VAL PRO CYS
SEQRES 17 A 494 GLY SER SER PRO GLY HIS ILE LYS GLU LEU PRO CYS GLY
SEQRES 18 A 494 GLU ARG TYR ALA VAL ALA PHE PHE CYS LEU ASP THR ALA
SEQRES 19 A 494 CYS VAL MET ILE PHE THR VAL GLU TYR LEU LEU ARG LEU
SEQRES 20 A 494 ALA ALA ALA PRO SER ARG TYR ARG PHE VAL ARG SER VAL
SEQRES 21 A 494 MET SER ILE ILE ASP VAL VAL ALA ILE LEU PRO TYR TYR
SEQRES 22 A 494 ILE GLY LEU VAL MET THR ASP ASN GLU ASP VAL SER GLY
SEQRES 23 A 494 ALA PHE VAL THR LEU ARG VAL PHE ARG VAL PHE ARG ILE
SEQRES 24 A 494 PHE LYS PHE SER ARG HIS SER GLN GLY LEU ARG ILE LEU
SEQRES 25 A 494 GLY TYR THR LEU LYS SER CYS ALA SER GLU LEU GLY PHE
SEQRES 26 A 494 LEU LEU PHE SER LEU THR MET ALA ILE ILE ILE PHE ALA
SEQRES 27 A 494 THR VAL MET PHE TYR ALA GLU LYS GLY SER SER ALA SER
SEQRES 28 A 494 LYS PHE THR SER ILE PRO ALA ALA PHE TRP TYR THR ILE
SEQRES 29 A 494 VAL THR MET THR THR LEU GLY TYR GLY ASP MET VAL PRO
SEQRES 30 A 494 LYS THR ILE ALA GLY LYS ILE PHE GLY SER ILE CYS SER
SEQRES 31 A 494 LEU SER GLY VAL LEU VAL ILE ALA LEU PRO VAL PRO VAL
SEQRES 32 A 494 ILE VAL SER ASN PHE SER ARG ILE TYR HIS GLN ASN GLN
SEQRES 33 A 494 ARG ALA ASP LYS ARG ARG ALA GLN LYS LYS ALA ARG LEU
SEQRES 34 A 494 ALA ARG ILE ARG ALA ALA LYS SER GLY SER ALA ASN ALA
SEQRES 35 A 494 TYR MET GLN SER LYS ARG SER GLY LEU LEU SER ASN GLN
SEQRES 36 A 494 LEU GLN SER SER GLU ASP GLU GLN ALA PHE VAL SER LYS
SEQRES 37 A 494 SER GLY SER SER PHE GLU THR GLN HIS HIS HIS LEU LEU
SEQRES 38 A 494 HIS CYS LEU GLU LYS THR THR ASN HIS GLU PHE VAL ASP
SEQRES 1 L 757 ALA LYS GLY ILE ALA ILE ALA LEU LEU VAL ILE LEU VAL
SEQRES 2 L 757 ILE CYS SER LEU ILE VAL THR SER VAL ILE LEU LEU THR
SEQRES 3 L 757 PRO ALA GLU ASP ASN SER LEU SER GLN LYS LYS LYS VAL
SEQRES 4 L 757 THR VAL GLU ASP LEU PHE SER GLU ASP PHE LYS ILE HIS
SEQRES 5 L 757 ASP PRO GLU ALA LYS TRP ILE SER ASP THR GLU PHE ILE
SEQRES 6 L 757 TYR ARG GLU GLN LYS GLY THR VAL ARG LEU TRP ASN VAL
SEQRES 7 L 757 GLU THR ASN THR SER THR VAL LEU ILE GLU GLY LYS LYS
SEQRES 8 L 757 ILE GLU SER LEU ARG ALA ILE ARG TYR GLU ILE SER PRO
SEQRES 9 L 757 ASP ARG GLU TYR ALA LEU PHE SER TYR ASN VAL GLU PRO
SEQRES 10 L 757 ILE TYR GLN HIS SER TYR THR GLY TYR TYR VAL LEU SER
SEQRES 11 L 757 LYS ILE PRO HIS GLY ASP PRO GLN SER LEU ASP PRO PRO
SEQRES 12 L 757 GLU VAL SER ASN ALA LYS LEU GLN TYR ALA GLY TRP GLY
SEQRES 13 L 757 PRO LYS GLY GLN GLN LEU ILE PHE ILE PHE GLU ASN ASN
SEQRES 14 L 757 ILE TYR TYR CYS ALA HIS VAL GLY LYS GLN ALA ILE ARG
SEQRES 15 L 757 VAL VAL SER THR GLY LYS GLU GLY VAL ILE TYR ASN GLY
SEQRES 16 L 757 LEU SER ASP TRP LEU TYR GLU GLU GLU ILE LEU LYS THR
SEQRES 17 L 757 HIS ILE ALA HIS TRP TRP SER PRO ASP GLY THR ARG LEU
SEQRES 18 L 757 ALA TYR ALA ALA ILE ASN ASP SER ARG VAL PRO ILE MET
SEQRES 19 L 757 GLU LEU PRO THR TYR THR GLY SER ILE TYR PRO THR VAL
SEQRES 20 L 757 LYS PRO TYR HIS TYR PRO LYS ALA GLY SER GLU ASN PRO
SEQRES 21 L 757 SER ILE SER LEU HIS VAL ILE GLY LEU ASN GLY PRO THR
SEQRES 22 L 757 HIS ASP LEU GLU MET MET PRO PRO ASP ASP PRO ARG MET
SEQRES 23 L 757 ARG GLU TYR TYR ILE THR MET VAL LYS TRP ALA THR SER
SEQRES 24 L 757 THR LYS VAL ALA VAL THR TRP LEU ASN ARG ALA GLN ASN
SEQRES 25 L 757 VAL SER ILE LEU THR LEU CYS ASP ALA THR THR GLY VAL
SEQRES 26 L 757 CYS THR LYS LYS HIS GLU ASP GLU SER GLU ALA TRP LEU
SEQRES 27 L 757 HIS ARG GLN ASN GLU GLU PRO VAL PHE SER LYS ASP GLY
SEQRES 28 L 757 ARG LYS PHE PHE PHE ILE ARG ALA ILE PRO GLN GLY GLY
SEQRES 29 L 757 ARG GLY LYS PHE TYR HIS ILE THR VAL SER SER SER GLN
SEQRES 30 L 757 PRO ASN SER SER ASN ASP ASN ILE GLN SER ILE THR SER
SEQRES 31 L 757 GLY ASP TRP ASP VAL THR LYS ILE LEU ALA TYR ASP GLU
SEQRES 32 L 757 LYS GLY ASN LYS ILE TYR PHE LEU SER THR GLU ASP LEU
SEQRES 33 L 757 PRO ARG ARG ARG GLN LEU TYR SER ALA ASN THR VAL GLY
SEQRES 34 L 757 ASN PHE ASN ARG GLN CYS LEU SER CYS ASP LEU VAL GLU
SEQRES 35 L 757 ASN CYS THR TYR PHE SER ALA SER PHE SER HIS SER MET
SEQRES 36 L 757 ASP PHE PHE LEU LEU LYS CYS GLU GLY PRO GLY VAL PRO
SEQRES 37 L 757 MET VAL THR VAL HIS ASN THR THR ASP LYS LYS LYS MET
SEQRES 38 L 757 PHE ASP LEU GLU THR ASN GLU HIS VAL LYS LYS ALA ILE
SEQRES 39 L 757 ASN ASP ARG GLN MET PRO LYS VAL GLU TYR ARG ASP ILE
SEQRES 40 L 757 GLU ILE ASP ASP TYR ASN LEU PRO MET GLN ILE LEU LYS
SEQRES 41 L 757 PRO ALA THR PHE THR ASP THR THR HIS TYR PRO LEU LEU
SEQRES 42 L 757 LEU VAL VAL ASP GLY THR PRO GLY SER GLN SER VAL ALA
SEQRES 43 L 757 GLU LYS PHE GLU VAL SER TRP GLU THR VAL MET VAL SER
SEQRES 44 L 757 SER HIS GLY ALA VAL VAL VAL LYS CYS ASP GLY ARG GLY
SEQRES 45 L 757 SER GLY PHE GLN GLY THR LYS LEU LEU HIS GLU VAL ARG
SEQRES 46 L 757 ARG ARG LEU GLY LEU LEU GLU GLU LYS ASP GLN MET GLU
SEQRES 47 L 757 ALA VAL ARG THR MET LEU LYS GLU GLN TYR ILE ASP ARG
SEQRES 48 L 757 THR ARG VAL ALA VAL PHE GLY LYS ASP TYR GLY GLY TYR
SEQRES 49 L 757 LEU SER THR TYR ILE LEU PRO ALA LYS GLY GLU ASN GLN
SEQRES 50 L 757 GLY GLN THR PHE THR CYS GLY SER ALA LEU SER PRO ILE
SEQRES 51 L 757 THR ASP PHE LYS LEU TYR ALA SER ALA PHE SER GLU ARG
SEQRES 52 L 757 TYR LEU GLY LEU HIS GLY LEU ASP ASN ARG ALA TYR GLU
SEQRES 53 L 757 MET THR LYS VAL ALA HIS ARG VAL SER ALA LEU GLU GLU
SEQRES 54 L 757 GLN GLN PHE LEU ILE ILE HIS PRO THR ALA ASP GLU LYS
SEQRES 55 L 757 ILE HIS PHE GLN HIS THR ALA GLU LEU ILE THR GLN LEU
SEQRES 56 L 757 ILE ARG GLY LYS ALA ASN TYR SER LEU GLN ILE TYR PRO
SEQRES 57 L 757 ASP GLU SER HIS TYR PHE THR SER SER SER LEU LYS GLN
SEQRES 58 L 757 HIS LEU TYR ARG SER ILE ILE ASN PHE PHE VAL GLU CYS
SEQRES 59 L 757 PHE ARG ILE
SEQRES 1 K 760 ALA ALA ALA ALA LYS GLY ILE ALA ILE ALA LEU LEU VAL
SEQRES 2 K 760 ILE LEU VAL ILE CYS SER LEU ILE VAL THR SER VAL ILE
SEQRES 3 K 760 LEU LEU THR PRO ALA GLU ASP ASN SER LEU SER GLN LYS
SEQRES 4 K 760 LYS LYS VAL THR VAL GLU ASP LEU PHE SER GLU ASP PHE
SEQRES 5 K 760 LYS ILE HIS ASP PRO GLU ALA LYS TRP ILE SER ASP THR
SEQRES 6 K 760 GLU PHE ILE TYR ARG GLU GLN LYS GLY THR VAL ARG LEU
SEQRES 7 K 760 TRP ASN VAL GLU THR ASN THR SER THR VAL LEU ILE GLU
SEQRES 8 K 760 GLY LYS LYS ILE GLU SER LEU ARG ALA ILE ARG TYR GLU
SEQRES 9 K 760 ILE SER PRO ASP ARG GLU TYR ALA LEU PHE SER TYR ASN
SEQRES 10 K 760 VAL GLU PRO ILE TYR GLN HIS SER TYR THR GLY TYR TYR
SEQRES 11 K 760 VAL LEU SER LYS ILE PRO HIS GLY ASP PRO GLN SER LEU
SEQRES 12 K 760 ASP PRO PRO GLU VAL SER ASN ALA LYS LEU GLN TYR ALA
SEQRES 13 K 760 GLY TRP GLY PRO LYS GLY GLN GLN LEU ILE PHE ILE PHE
SEQRES 14 K 760 GLU ASN ASN ILE TYR TYR CYS ALA HIS VAL GLY LYS GLN
SEQRES 15 K 760 ALA ILE ARG VAL VAL SER THR GLY LYS GLU GLY VAL ILE
SEQRES 16 K 760 TYR ASN GLY LEU SER ASP TRP LEU TYR GLU GLU GLU ILE
SEQRES 17 K 760 LEU LYS THR HIS ILE ALA HIS TRP TRP SER PRO ASP GLY
SEQRES 18 K 760 THR ARG LEU ALA TYR ALA ALA ILE ASN ASP SER ARG VAL
SEQRES 19 K 760 PRO ILE MET GLU LEU PRO THR TYR THR GLY SER ILE TYR
SEQRES 20 K 760 PRO THR VAL LYS PRO TYR HIS TYR PRO LYS ALA GLY SER
SEQRES 21 K 760 GLU ASN PRO SER ILE SER LEU HIS VAL ILE GLY LEU ASN
SEQRES 22 K 760 GLY PRO THR HIS ASP LEU GLU MET MET PRO PRO ASP ASP
SEQRES 23 K 760 PRO ARG MET ARG GLU TYR TYR ILE THR MET VAL LYS TRP
SEQRES 24 K 760 ALA THR SER THR LYS VAL ALA VAL THR TRP LEU ASN ARG
SEQRES 25 K 760 ALA GLN ASN VAL SER ILE LEU THR LEU CYS ASP ALA THR
SEQRES 26 K 760 THR GLY VAL CYS THR LYS LYS HIS GLU ASP GLU SER GLU
SEQRES 27 K 760 ALA TRP LEU HIS ARG GLN ASN GLU GLU PRO VAL PHE SER
SEQRES 28 K 760 LYS ASP GLY ARG LYS PHE PHE PHE ILE ARG ALA ILE PRO
SEQRES 29 K 760 GLN GLY GLY ARG GLY LYS PHE TYR HIS ILE THR VAL SER
SEQRES 30 K 760 SER SER GLN PRO ASN SER SER ASN ASP ASN ILE GLN SER
SEQRES 31 K 760 ILE THR SER GLY ASP TRP ASP VAL THR LYS ILE LEU ALA
SEQRES 32 K 760 TYR ASP GLU LYS GLY ASN LYS ILE TYR PHE LEU SER THR
SEQRES 33 K 760 GLU ASP LEU PRO ARG ARG ARG GLN LEU TYR SER ALA ASN
SEQRES 34 K 760 THR VAL GLY ASN PHE ASN ARG GLN CYS LEU SER CYS ASP
SEQRES 35 K 760 LEU VAL GLU ASN CYS THR TYR PHE SER ALA SER PHE SER
SEQRES 36 K 760 HIS SER MET ASP PHE PHE LEU LEU LYS CYS GLU GLY PRO
SEQRES 37 K 760 GLY VAL PRO MET VAL THR VAL HIS ASN THR THR ASP LYS
SEQRES 38 K 760 LYS LYS MET PHE ASP LEU GLU THR ASN GLU HIS VAL LYS
SEQRES 39 K 760 LYS ALA ILE ASN ASP ARG GLN MET PRO LYS VAL GLU TYR
SEQRES 40 K 760 ARG ASP ILE GLU ILE ASP ASP TYR ASN LEU PRO MET GLN
SEQRES 41 K 760 ILE LEU LYS PRO ALA THR PHE THR ASP THR THR HIS TYR
SEQRES 42 K 760 PRO LEU LEU LEU VAL VAL ASP GLY THR PRO GLY SER GLN
SEQRES 43 K 760 SER VAL ALA GLU LYS PHE GLU VAL SER TRP GLU THR VAL
SEQRES 44 K 760 MET VAL SER SER HIS GLY ALA VAL VAL VAL LYS CYS ASP
SEQRES 45 K 760 GLY ARG GLY SER GLY PHE GLN GLY THR LYS LEU LEU HIS
SEQRES 46 K 760 GLU VAL ARG ARG ARG LEU GLY LEU LEU GLU GLU LYS ASP
SEQRES 47 K 760 GLN MET GLU ALA VAL ARG THR MET LEU LYS GLU GLN TYR
SEQRES 48 K 760 ILE ASP ARG THR ARG VAL ALA VAL PHE GLY LYS ASP TYR
SEQRES 49 K 760 GLY GLY TYR LEU SER THR TYR ILE LEU PRO ALA LYS GLY
SEQRES 50 K 760 GLU ASN GLN GLY GLN THR PHE THR CYS GLY SER ALA LEU
SEQRES 51 K 760 SER PRO ILE THR ASP PHE LYS LEU TYR ALA SER ALA PHE
SEQRES 52 K 760 SER GLU ARG TYR LEU GLY LEU HIS GLY LEU ASP ASN ARG
SEQRES 53 K 760 ALA TYR GLU MET THR LYS VAL ALA HIS ARG VAL SER ALA
SEQRES 54 K 760 LEU GLU GLU GLN GLN PHE LEU ILE ILE HIS PRO THR ALA
SEQRES 55 K 760 ASP GLU LYS ILE HIS PHE GLN HIS THR ALA GLU LEU ILE
SEQRES 56 K 760 THR GLN LEU ILE ARG GLY LYS ALA ASN TYR SER LEU GLN
SEQRES 57 K 760 ILE TYR PRO ASP GLU SER HIS TYR PHE THR SER SER SER
SEQRES 58 K 760 LEU LYS GLN HIS LEU TYR ARG SER ILE ILE ASN PHE PHE
SEQRES 59 K 760 VAL GLU CYS PHE ARG ILE
SEQRES 1 H 180 GLU GLY LEU GLU GLN LEU GLU ALA GLN THR ASN PHE THR
SEQRES 2 H 180 LYS ARG GLU LEU GLN VAL LEU TYR ARG GLY PHE LYS ASN
SEQRES 3 H 180 GLU CYS PRO SER GLY VAL VAL ASN GLU ASP THR PHE LYS
SEQRES 4 H 180 GLN ILE TYR ALA GLN PHE PHE PRO HIS GLY ASP ALA SER
SEQRES 5 H 180 THR TYR ALA HIS TYR LEU PHE ASN ALA PHE ASP THR THR
SEQRES 6 H 180 GLN THR GLY SER VAL LYS PHE GLU ASP PHE VAL THR ALA
SEQRES 7 H 180 LEU SER ILE LEU LEU ARG GLY THR VAL HIS GLU LYS LEU
SEQRES 8 H 180 ARG TRP THR PHE ASN LEU TYR ASP ILE ASN LYS ASP GLY
SEQRES 9 H 180 TYR ILE ASN LYS GLU GLU MET MET ASP ILE VAL LYS ALA
SEQRES 10 H 180 ILE TYR ASP MET MET GLY LYS TYR THR TYR PRO VAL LEU
SEQRES 11 H 180 LYS GLU ASP THR PRO ARG GLN HIS VAL ASP VAL PHE PHE
SEQRES 12 H 180 GLN LYS MET ASP LYS ASN LYS ASP GLY ILE VAL THR LEU
SEQRES 13 H 180 ASP GLU PHE LEU GLU SER CYS GLN GLU ASP ASP ASN ILE
SEQRES 14 H 180 MET ARG SER LEU GLN LEU PHE GLN ASN VAL MET
SEQRES 1 D 494 ALA ALA GLY VAL ALA ALA TRP LEU PRO PHE ALA ARG ALA
SEQRES 2 D 494 ALA ALA ILE GLY TRP MET PRO VAL ALA SER GLY PRO MET
SEQRES 3 D 494 PRO ALA PRO PRO ARG GLN GLU ARG LYS ARG THR GLN ASP
SEQRES 4 D 494 ALA LEU ILE VAL LEU ASN VAL SER GLY THR ARG PHE GLN
SEQRES 5 D 494 THR TRP GLN ASP THR LEU GLU ARG TYR PRO ASP THR LEU
SEQRES 6 D 494 LEU GLY SER SER GLU ARG ASP PHE PHE TYR HIS PRO GLU
SEQRES 7 D 494 THR GLN GLN TYR PHE PHE ASP ARG ASP PRO ASP ILE PHE
SEQRES 8 D 494 ARG HIS ILE LEU ASN PHE TYR ARG THR GLY LYS LEU HIS
SEQRES 9 D 494 TYR PRO ARG HIS GLU CYS ILE SER ALA TYR ASP GLU GLU
SEQRES 10 D 494 LEU ALA PHE PHE GLY LEU ILE PRO GLU ILE ILE GLY ASP
SEQRES 11 D 494 CYS CYS TYR GLU GLU TYR LYS ASP ARG ARG ARG GLU ASN
SEQRES 12 D 494 ALA GLU ARG LEU GLN ASP ASP ALA ASP THR ASP THR ALA
SEQRES 13 D 494 GLY GLU SER ALA LEU PRO THR MET THR ALA ARG GLN ARG
SEQRES 14 D 494 VAL TRP ARG ALA PHE GLU ASN PRO HIS THR SER THR MET
SEQRES 15 D 494 ALA LEU VAL PHE TYR TYR VAL THR GLY PHE PHE ILE ALA
SEQRES 16 D 494 VAL SER VAL ILE ALA ASN VAL VAL GLU THR VAL PRO CYS
SEQRES 17 D 494 GLY SER SER PRO GLY HIS ILE LYS GLU LEU PRO CYS GLY
SEQRES 18 D 494 GLU ARG TYR ALA VAL ALA PHE PHE CYS LEU ASP THR ALA
SEQRES 19 D 494 CYS VAL MET ILE PHE THR VAL GLU TYR LEU LEU ARG LEU
SEQRES 20 D 494 ALA ALA ALA PRO SER ARG TYR ARG PHE VAL ARG SER VAL
SEQRES 21 D 494 MET SER ILE ILE ASP VAL VAL ALA ILE LEU PRO TYR TYR
SEQRES 22 D 494 ILE GLY LEU VAL MET THR ASP ASN GLU ASP VAL SER GLY
SEQRES 23 D 494 ALA PHE VAL THR LEU ARG VAL PHE ARG VAL PHE ARG ILE
SEQRES 24 D 494 PHE LYS PHE SER ARG HIS SER GLN GLY LEU ARG ILE LEU
SEQRES 25 D 494 GLY TYR THR LEU LYS SER CYS ALA SER GLU LEU GLY PHE
SEQRES 26 D 494 LEU LEU PHE SER LEU THR MET ALA ILE ILE ILE PHE ALA
SEQRES 27 D 494 THR VAL MET PHE TYR ALA GLU LYS GLY SER SER ALA SER
SEQRES 28 D 494 LYS PHE THR SER ILE PRO ALA ALA PHE TRP TYR THR ILE
SEQRES 29 D 494 VAL THR MET THR THR LEU GLY TYR GLY ASP MET VAL PRO
SEQRES 30 D 494 LYS THR ILE ALA GLY LYS ILE PHE GLY SER ILE CYS SER
SEQRES 31 D 494 LEU SER GLY VAL LEU VAL ILE ALA LEU PRO VAL PRO VAL
SEQRES 32 D 494 ILE VAL SER ASN PHE SER ARG ILE TYR HIS GLN ASN GLN
SEQRES 33 D 494 ARG ALA ASP LYS ARG ARG ALA GLN LYS LYS ALA ARG LEU
SEQRES 34 D 494 ALA ARG ILE ARG ALA ALA LYS SER GLY SER ALA ASN ALA
SEQRES 35 D 494 TYR MET GLN SER LYS ARG SER GLY LEU LEU SER ASN GLN
SEQRES 36 D 494 LEU GLN SER SER GLU ASP GLU GLN ALA PHE VAL SER LYS
SEQRES 37 D 494 SER GLY SER SER PHE GLU THR GLN HIS HIS HIS LEU LEU
SEQRES 38 D 494 HIS CYS LEU GLU LYS THR THR ASN HIS GLU PHE VAL ASP
SEQRES 1 G 181 PRO GLU GLY LEU GLU GLN LEU GLU ALA GLN THR ASN PHE
SEQRES 2 G 181 THR LYS ARG GLU LEU GLN VAL LEU TYR ARG GLY PHE LYS
SEQRES 3 G 181 ASN GLU CYS PRO SER GLY VAL VAL ASN GLU ASP THR PHE
SEQRES 4 G 181 LYS GLN ILE TYR ALA GLN PHE PHE PRO HIS GLY ASP ALA
SEQRES 5 G 181 SER THR TYR ALA HIS TYR LEU PHE ASN ALA PHE ASP THR
SEQRES 6 G 181 THR GLN THR GLY SER VAL LYS PHE GLU ASP PHE VAL THR
SEQRES 7 G 181 ALA LEU SER ILE LEU LEU ARG GLY THR VAL HIS GLU LYS
SEQRES 8 G 181 LEU ARG TRP THR PHE ASN LEU TYR ASP ILE ASN LYS ASP
SEQRES 9 G 181 GLY TYR ILE ASN LYS GLU GLU MET MET ASP ILE VAL LYS
SEQRES 10 G 181 ALA ILE TYR ASP MET MET GLY LYS TYR THR TYR PRO VAL
SEQRES 11 G 181 LEU LYS GLU ASP THR PRO ARG GLN HIS VAL ASP VAL PHE
SEQRES 12 G 181 PHE GLN LYS MET ASP LYS ASN LYS ASP GLY ILE VAL THR
SEQRES 13 G 181 LEU ASP GLU PHE LEU GLU SER CYS GLN GLU ASP ASP ASN
SEQRES 14 G 181 ILE MET ARG SER LEU GLN LEU PHE GLN ASN VAL MET
SEQRES 1 C 494 ALA ALA GLY VAL ALA ALA TRP LEU PRO PHE ALA ARG ALA
SEQRES 2 C 494 ALA ALA ILE GLY TRP MET PRO VAL ALA SER GLY PRO MET
SEQRES 3 C 494 PRO ALA PRO PRO ARG GLN GLU ARG LYS ARG THR GLN ASP
SEQRES 4 C 494 ALA LEU ILE VAL LEU ASN VAL SER GLY THR ARG PHE GLN
SEQRES 5 C 494 THR TRP GLN ASP THR LEU GLU ARG TYR PRO ASP THR LEU
SEQRES 6 C 494 LEU GLY SER SER GLU ARG ASP PHE PHE TYR HIS PRO GLU
SEQRES 7 C 494 THR GLN GLN TYR PHE PHE ASP ARG ASP PRO ASP ILE PHE
SEQRES 8 C 494 ARG HIS ILE LEU ASN PHE TYR ARG THR GLY LYS LEU HIS
SEQRES 9 C 494 TYR PRO ARG HIS GLU CYS ILE SER ALA TYR ASP GLU GLU
SEQRES 10 C 494 LEU ALA PHE PHE GLY LEU ILE PRO GLU ILE ILE GLY ASP
SEQRES 11 C 494 CYS CYS TYR GLU GLU TYR LYS ASP ARG ARG ARG GLU ASN
SEQRES 12 C 494 ALA GLU ARG LEU GLN ASP ASP ALA ASP THR ASP THR ALA
SEQRES 13 C 494 GLY GLU SER ALA LEU PRO THR MET THR ALA ARG GLN ARG
SEQRES 14 C 494 VAL TRP ARG ALA PHE GLU ASN PRO HIS THR SER THR MET
SEQRES 15 C 494 ALA LEU VAL PHE TYR TYR VAL THR GLY PHE PHE ILE ALA
SEQRES 16 C 494 VAL SER VAL ILE ALA ASN VAL VAL GLU THR VAL PRO CYS
SEQRES 17 C 494 GLY SER SER PRO GLY HIS ILE LYS GLU LEU PRO CYS GLY
SEQRES 18 C 494 GLU ARG TYR ALA VAL ALA PHE PHE CYS LEU ASP THR ALA
SEQRES 19 C 494 CYS VAL MET ILE PHE THR VAL GLU TYR LEU LEU ARG LEU
SEQRES 20 C 494 ALA ALA ALA PRO SER ARG TYR ARG PHE VAL ARG SER VAL
SEQRES 21 C 494 MET SER ILE ILE ASP VAL VAL ALA ILE LEU PRO TYR TYR
SEQRES 22 C 494 ILE GLY LEU VAL MET THR ASP ASN GLU ASP VAL SER GLY
SEQRES 23 C 494 ALA PHE VAL THR LEU ARG VAL PHE ARG VAL PHE ARG ILE
SEQRES 24 C 494 PHE LYS PHE SER ARG HIS SER GLN GLY LEU ARG ILE LEU
SEQRES 25 C 494 GLY TYR THR LEU LYS SER CYS ALA SER GLU LEU GLY PHE
SEQRES 26 C 494 LEU LEU PHE SER LEU THR MET ALA ILE ILE ILE PHE ALA
SEQRES 27 C 494 THR VAL MET PHE TYR ALA GLU LYS GLY SER SER ALA SER
SEQRES 28 C 494 LYS PHE THR SER ILE PRO ALA ALA PHE TRP TYR THR ILE
SEQRES 29 C 494 VAL THR MET THR THR LEU GLY TYR GLY ASP MET VAL PRO
SEQRES 30 C 494 LYS THR ILE ALA GLY LYS ILE PHE GLY SER ILE CYS SER
SEQRES 31 C 494 LEU SER GLY VAL LEU VAL ILE ALA LEU PRO VAL PRO VAL
SEQRES 32 C 494 ILE VAL SER ASN PHE SER ARG ILE TYR HIS GLN ASN GLN
SEQRES 33 C 494 ARG ALA ASP LYS ARG ARG ALA GLN LYS LYS ALA ARG LEU
SEQRES 34 C 494 ALA ARG ILE ARG ALA ALA LYS SER GLY SER ALA ASN ALA
SEQRES 35 C 494 TYR MET GLN SER LYS ARG SER GLY LEU LEU SER ASN GLN
SEQRES 36 C 494 LEU GLN SER SER GLU ASP GLU GLN ALA PHE VAL SER LYS
SEQRES 37 C 494 SER GLY SER SER PHE GLU THR GLN HIS HIS HIS LEU LEU
SEQRES 38 C 494 HIS CYS LEU GLU LYS THR THR ASN HIS GLU PHE VAL ASP
HELIX 1 AA1 ALA J 31 THR J 56 1 26
HELIX 2 AA2 THR J 70 SER J 76 1 7
HELIX 3 AA3 GLU J 77 LYS J 80 5 4
HELIX 4 AA4 GLU J 118 SER J 124 5 7
HELIX 5 AA5 ASP J 228 GLU J 234 1 7
HELIX 6 AA6 ASN J 517 ASP J 526 1 10
HELIX 7 AA7 SER J 582 GLY J 592 1 11
HELIX 8 AA8 GLY J 607 VAL J 614 1 8
HELIX 9 AA9 LEU J 621 LYS J 635 1 15
HELIX 10 AB1 ASP J 650 ILE J 659 1 10
HELIX 11 AB2 ASP J 682 TYR J 686 5 5
HELIX 12 AB3 ALA J 687 GLY J 696 1 10
HELIX 13 AB4 ALA J 704 THR J 708 5 5
HELIX 14 AB5 ALA J 711 SER J 715 5 5
HELIX 15 AB6 HIS J 734 LYS J 749 1 16
HELIX 16 AB7 SER J 766 CYS J 784 1 19
HELIX 17 AB8 ALA I 29 LEU I 54 1 26
HELIX 18 AB9 THR I 70 SER I 76 1 7
HELIX 19 AC1 GLU I 118 SER I 124 5 7
HELIX 20 AC2 ASP I 228 GLU I 234 1 7
HELIX 21 AC3 ASN I 517 ARG I 527 1 11
HELIX 22 AC4 SER I 582 SER I 590 1 9
HELIX 23 AC5 GLY I 607 GLU I 613 1 7
HELIX 24 AC6 LEU I 620 LYS I 635 1 16
HELIX 25 AC7 ASP I 650 ILE I 659 1 10
HELIX 26 AC8 ASP I 682 TYR I 686 5 5
HELIX 27 AC9 ALA I 687 GLY I 696 1 10
HELIX 28 AD1 HIS I 712 ALA I 716 5 5
HELIX 29 AD2 HIS I 734 LYS I 749 1 16
HELIX 30 AD3 SER I 766 ARG I 786 1 21
HELIX 31 AD4 THR F 49 CYS F 64 1 16
HELIX 32 AD5 ASN F 70 PHE F 82 1 13
HELIX 33 AD6 SER F 88 ASP F 99 1 12
HELIX 34 AD7 THR F 100 THR F 103 5 4
HELIX 35 AD8 LYS F 107 ARG F 120 1 14
HELIX 36 AD9 THR F 122 ASP F 135 1 14
HELIX 37 AE1 ASN F 143 ASP F 156 1 14
HELIX 38 AE2 GLU F 168 MET F 182 1 15
HELIX 39 AE3 LEU F 192 ASP F 202 1 11
HELIX 40 AE4 ASP F 202 SER F 208 1 7
HELIX 41 AE5 LEU F 209 ASN F 214 1 6
HELIX 42 AE6 VAL B 5 ALA B 7 5 3
HELIX 43 AE7 TRP B 8 MET B 20 1 13
HELIX 44 AE8 GLN B 56 ARG B 61 1 6
HELIX 45 AE9 SER B 70 PHE B 74 5 5
HELIX 46 AF1 ASP B 90 GLY B 102 1 13
HELIX 47 AF2 CYS B 111 PHE B 122 1 12
HELIX 48 AF3 ILE B 125 ILE B 129 5 5
HELIX 49 AF4 GLY B 130 ALA B 152 1 23
HELIX 50 AF5 GLN B 169 ASN B 177 1 9
HELIX 51 AF6 SER B 181 VAL B 207 1 27
HELIX 52 AF7 VAL B 207 SER B 212 1 6
HELIX 53 AF8 ALA B 228 ALA B 250 1 23
HELIX 54 AF9 TYR B 255 SER B 260 1 6
HELIX 55 AG1 SER B 260 GLU B 283 1 24
HELIX 56 AG2 ALA B 288 ARG B 296 1 9
HELIX 57 AG3 PHE B 298 PHE B 303 1 6
HELIX 58 AG4 SER B 307 CYS B 320 1 14
HELIX 59 AG5 CYS B 320 LYS B 347 1 28
HELIX 60 AG6 SER B 356 THR B 369 1 14
HELIX 61 AG7 THR B 380 LEU B 400 1 21
HELIX 62 AG8 PRO B 401 SER B 450 1 50
HELIX 63 AG9 SER B 473 ASN B 490 1 18
HELIX 64 AH1 THR E 49 CYS E 64 1 16
HELIX 65 AH2 GLU E 71 GLN E 80 1 10
HELIX 66 AH3 ALA E 87 ASP E 99 1 13
HELIX 67 AH4 THR E 100 THR E 103 5 4
HELIX 68 AH5 PHE E 108 GLY E 121 1 14
HELIX 69 AH6 THR E 122 ASP E 135 1 14
HELIX 70 AH7 MET E 147 ASP E 156 1 10
HELIX 71 AH8 MET E 157 GLY E 159 5 3
HELIX 72 AH9 ASP E 169 MET E 182 1 14
HELIX 73 AI1 LEU E 192 GLN E 200 1 9
HELIX 74 AI2 ASP E 202 ASN E 214 1 13
HELIX 75 AI3 VAL A 5 ALA A 7 5 3
HELIX 76 AI4 TRP A 8 GLY A 18 1 11
HELIX 77 AI5 GLN A 56 GLU A 60 1 5
HELIX 78 AI6 ASP A 88 GLY A 102 1 15
HELIX 79 AI7 CYS A 111 PHE A 122 1 12
HELIX 80 AI8 CYS A 133 ALA A 152 1 20
HELIX 81 AI9 ARG A 168 ASN A 177 1 10
HELIX 82 AJ1 SER A 181 GLU A 205 1 25
HELIX 83 AJ2 ALA A 228 ALA A 251 1 24
HELIX 84 AJ3 SER A 253 ARG A 259 1 7
HELIX 85 AJ4 SER A 260 ASP A 281 1 22
HELIX 86 AJ5 ALA A 288 ARG A 296 1 9
HELIX 87 AJ6 VAL A 297 ARG A 305 5 9
HELIX 88 AJ7 SER A 307 CYS A 320 1 14
HELIX 89 AJ8 ALA A 321 GLU A 346 1 26
HELIX 90 AJ9 SER A 356 THR A 369 1 14
HELIX 91 AK1 THR A 380 LEU A 400 1 21
HELIX 92 AK2 PRO A 401 SER A 450 1 50
HELIX 93 AK3 SER A 473 THR A 489 1 17
HELIX 94 AK4 LYS L 32 THR L 56 1 25
HELIX 95 AK5 THR L 70 SER L 76 1 7
HELIX 96 AK6 GLU L 77 LYS L 80 5 4
HELIX 97 AK7 GLU L 118 SER L 124 5 7
HELIX 98 AK8 ASP L 228 GLU L 234 1 7
HELIX 99 AK9 ASN L 517 ASP L 526 1 10
HELIX 100 AL1 SER L 582 GLY L 592 1 11
HELIX 101 AL2 GLY L 607 VAL L 614 1 8
HELIX 102 AL3 LEU L 621 LYS L 635 1 15
HELIX 103 AL4 ASP L 650 ILE L 659 1 10
HELIX 104 AL5 ASP L 682 TYR L 686 5 5
HELIX 105 AL6 ALA L 687 GLY L 696 1 10
HELIX 106 AL7 ALA L 704 THR L 708 5 5
HELIX 107 AL8 ALA L 711 SER L 715 5 5
HELIX 108 AL9 HIS L 734 LYS L 749 1 16
HELIX 109 AM1 SER L 766 CYS L 784 1 19
HELIX 110 AM2 ALA K 29 LEU K 54 1 26
HELIX 111 AM3 THR K 70 SER K 76 1 7
HELIX 112 AM4 GLU K 118 SER K 124 5 7
HELIX 113 AM5 ASP K 228 GLU K 234 1 7
HELIX 114 AM6 ASN K 517 ARG K 527 1 11
HELIX 115 AM7 SER K 582 SER K 590 1 9
HELIX 116 AM8 GLY K 607 GLU K 613 1 7
HELIX 117 AM9 LEU K 620 LYS K 635 1 16
HELIX 118 AN1 ASP K 650 ILE K 659 1 10
HELIX 119 AN2 ASP K 682 TYR K 686 5 5
HELIX 120 AN3 ALA K 687 GLY K 696 1 10
HELIX 121 AN4 HIS K 712 ALA K 716 5 5
HELIX 122 AN5 HIS K 734 LYS K 749 1 16
HELIX 123 AN6 SER K 766 ARG K 786 1 21
HELIX 124 AN7 THR H 49 CYS H 64 1 16
HELIX 125 AN8 ASN H 70 PHE H 82 1 13
HELIX 126 AN9 SER H 88 ASP H 99 1 12
HELIX 127 AO1 THR H 100 THR H 103 5 4
HELIX 128 AO2 LYS H 107 ARG H 120 1 14
HELIX 129 AO3 THR H 122 ASP H 135 1 14
HELIX 130 AO4 ASN H 143 ASP H 156 1 14
HELIX 131 AO5 GLU H 168 MET H 182 1 15
HELIX 132 AO6 LEU H 192 ASP H 202 1 11
HELIX 133 AO7 ASP H 202 SER H 208 1 7
HELIX 134 AO8 LEU H 209 ASN H 214 1 6
HELIX 135 AO9 VAL D 5 ALA D 7 5 3
HELIX 136 AP1 TRP D 8 MET D 20 1 13
HELIX 137 AP2 GLN D 56 ARG D 61 1 6
HELIX 138 AP3 SER D 70 PHE D 74 5 5
HELIX 139 AP4 ASP D 90 GLY D 102 1 13
HELIX 140 AP5 CYS D 111 PHE D 122 1 12
HELIX 141 AP6 ILE D 125 ILE D 129 5 5
HELIX 142 AP7 GLY D 130 ALA D 152 1 23
HELIX 143 AP8 GLN D 169 ASN D 177 1 9
HELIX 144 AP9 SER D 181 VAL D 207 1 27
HELIX 145 AQ1 VAL D 207 SER D 212 1 6
HELIX 146 AQ2 ALA D 228 ALA D 250 1 23
HELIX 147 AQ3 TYR D 255 SER D 260 1 6
HELIX 148 AQ4 SER D 260 GLU D 283 1 24
HELIX 149 AQ5 ALA D 288 ARG D 296 1 9
HELIX 150 AQ6 PHE D 298 PHE D 303 1 6
HELIX 151 AQ7 SER D 307 CYS D 320 1 14
HELIX 152 AQ8 CYS D 320 LYS D 347 1 28
HELIX 153 AQ9 SER D 356 THR D 369 1 14
HELIX 154 AR1 THR D 380 LEU D 400 1 21
HELIX 155 AR2 PRO D 401 SER D 450 1 50
HELIX 156 AR3 SER D 473 ASN D 490 1 18
HELIX 157 AR4 THR G 49 CYS G 64 1 16
HELIX 158 AR5 GLU G 71 GLN G 80 1 10
HELIX 159 AR6 ALA G 87 ASP G 99 1 13
HELIX 160 AR7 THR G 100 THR G 103 5 4
HELIX 161 AR8 PHE G 108 GLY G 121 1 14
HELIX 162 AR9 THR G 122 ASP G 135 1 14
HELIX 163 AS1 MET G 147 ASP G 156 1 10
HELIX 164 AS2 MET G 157 GLY G 159 5 3
HELIX 165 AS3 ASP G 169 MET G 182 1 14
HELIX 166 AS4 LEU G 192 GLN G 200 1 9
HELIX 167 AS5 ASP G 202 ASN G 214 1 13
HELIX 168 AS6 VAL C 5 ALA C 7 5 3
HELIX 169 AS7 TRP C 8 GLY C 18 1 11
HELIX 170 AS8 GLN C 56 GLU C 60 1 5
HELIX 171 AS9 ASP C 88 GLY C 102 1 15
HELIX 172 AT1 CYS C 111 PHE C 122 1 12
HELIX 173 AT2 CYS C 133 ALA C 152 1 20
HELIX 174 AT3 ARG C 168 ASN C 177 1 10
HELIX 175 AT4 SER C 181 GLU C 205 1 25
HELIX 176 AT5 ALA C 228 ALA C 251 1 24
HELIX 177 AT6 SER C 253 ARG C 259 1 7
HELIX 178 AT7 SER C 260 ASP C 281 1 22
HELIX 179 AT8 ALA C 288 ARG C 296 1 9
HELIX 180 AT9 VAL C 297 ARG C 305 5 9
HELIX 181 AU1 SER C 307 CYS C 320 1 14
HELIX 182 AU2 ALA C 321 GLU C 346 1 26
HELIX 183 AU3 SER C 356 THR C 369 1 14
HELIX 184 AU4 THR C 380 LEU C 400 1 21
HELIX 185 AU5 PRO C 401 SER C 450 1 50
HELIX 186 AU6 SER C 473 THR C 489 1 17
SHEET 1 AA1 2 VAL J 103 ASN J 107 0
SHEET 2 AA1 2 THR J 112 ILE J 117 -1 O THR J 114 N LEU J 105
SHEET 1 AA2 4 ARG J 129 ILE J 132 0
SHEET 2 AA2 4 TYR J 138 GLU J 146 -1 O SER J 142 N ARG J 129
SHEET 3 AA2 4 THR J 154 LYS J 161 -1 O VAL J 158 N PHE J 141
SHEET 4 AA2 4 GLN J 168 SER J 169 -1 O GLN J 168 N LEU J 159
SHEET 1 AA3 2 LEU J 192 ILE J 195 0
SHEET 2 AA3 2 ILE J 200 CYS J 203 -1 O CYS J 203 N LEU J 192
SHEET 1 AA4 6 ASP J 305 GLU J 307 0
SHEET 2 AA4 6 SER J 291 GLY J 298 -1 N VAL J 296 O LEU J 306
SHEET 3 AA4 6 ARG J 250 ASN J 257 -1 N ASN J 257 O SER J 291
SHEET 4 AA4 6 ILE J 240 TRP J 244 -1 N TRP J 243 O ALA J 252
SHEET 5 AA4 6 ILE J 222 LEU J 226 -1 N GLY J 225 O ALA J 241
SHEET 6 AA4 6 ARG J 250 ASN J 257 -1 O ILE J 256 N TYR J 223
SHEET 1 AA5 2 ILE J 263 LEU J 266 0
SHEET 2 AA5 2 LYS J 278 HIS J 281 -1 O TYR J 280 N MET J 264
SHEET 1 AA6 4 TYR J 319 LYS J 325 0
SHEET 2 AA6 4 LYS J 331 ASN J 338 -1 O ALA J 333 N LYS J 325
SHEET 3 AA6 4 VAL J 343 ASP J 350 -1 O THR J 347 N VAL J 334
SHEET 4 AA6 4 CYS J 356 GLU J 363 -1 O THR J 357 N LEU J 348
SHEET 1 AA7 2 PHE J 384 ILE J 390 0
SHEET 2 AA7 2 PHE J 398 SER J 404 -1 O HIS J 400 N ARG J 388
SHEET 1 AA8 4 VAL J 425 ASP J 432 0
SHEET 2 AA8 4 LYS J 437 SER J 442 -1 O TYR J 439 N ALA J 430
SHEET 3 AA8 4 GLN J 451 ALA J 455 -1 O TYR J 453 N PHE J 440
SHEET 4 AA8 4 GLN J 464 CYS J 465 -1 O GLN J 464 N SER J 454
SHEET 1 AA9 4 SER J 478 PHE J 481 0
SHEET 2 AA9 4 PHE J 487 LYS J 491 -1 O LEU J 489 N SER J 480
SHEET 3 AA9 4 VAL J 500 ASN J 504 -1 O HIS J 503 N PHE J 488
SHEET 4 AA9 4 LYS J 510 GLU J 515 -1 O GLU J 515 N VAL J 500
SHEET 1 AB1 8 LYS J 531 TYR J 534 0
SHEET 2 AB1 8 MET J 546 LYS J 550 -1 O ILE J 548 N GLU J 533
SHEET 3 AB1 8 VAL J 595 CYS J 598 -1 O LYS J 597 N GLN J 547
SHEET 4 AB1 8 LEU J 562 VAL J 566 1 N VAL J 565 O VAL J 596
SHEET 5 AB1 8 VAL J 644 GLY J 648 1 O PHE J 647 N VAL J 566
SHEET 6 AB1 8 CYS J 673 LEU J 677 1 O CYS J 673 N VAL J 646
SHEET 7 AB1 8 GLN J 721 PRO J 727 1 O GLN J 721 N GLY J 674
SHEET 8 AB1 8 GLN J 755 TYR J 757 1 O GLN J 755 N ILE J 724
SHEET 1 AB2 2 ILE J 537 ILE J 539 0
SHEET 2 AB2 2 TYR J 542 LEU J 544 -1 O TYR J 542 N ILE J 539
SHEET 1 AB3 2 ARG I 104 ASN I 107 0
SHEET 2 AB3 2 THR I 112 VAL I 115 -1 O THR I 112 N ASN I 107
SHEET 1 AB4 4 ARG I 129 ILE I 132 0
SHEET 2 AB4 4 TYR I 138 TYR I 143 -1 O SER I 142 N ARG I 129
SHEET 3 AB4 4 TYR I 156 LYS I 161 -1 O TYR I 156 N TYR I 143
SHEET 4 AB4 4 GLN I 168 SER I 169 -1 O GLN I 168 N LEU I 159
SHEET 1 AB5 3 LEU I 192 ILE I 195 0
SHEET 2 AB5 3 ILE I 200 CYS I 203 -1 O CYS I 203 N LEU I 192
SHEET 3 AB5 3 ILE I 211 VAL I 214 -1 O VAL I 214 N ILE I 200
SHEET 1 AB6 3 ILE I 222 ASN I 224 0
SHEET 2 AB6 3 ARG I 250 ASN I 257 -1 O ILE I 256 N TYR I 223
SHEET 3 AB6 3 HIS I 242 TRP I 244 -1 N TRP I 243 O ALA I 252
SHEET 1 AB7 4 ILE I 222 ASN I 224 0
SHEET 2 AB7 4 ARG I 250 ASN I 257 -1 O ILE I 256 N TYR I 223
SHEET 3 AB7 4 SER I 291 GLY I 298 -1 O HIS I 295 N TYR I 253
SHEET 4 AB7 4 LEU I 306 MET I 308 -1 O MET I 308 N LEU I 294
SHEET 1 AB8 2 ILE I 263 LEU I 266 0
SHEET 2 AB8 2 LYS I 278 HIS I 281 -1 O TYR I 280 N MET I 264
SHEET 1 AB9 4 TYR I 319 TRP I 326 0
SHEET 2 AB9 4 LYS I 331 ASN I 338 -1 O ALA I 333 N LYS I 325
SHEET 3 AB9 4 VAL I 343 ASP I 350 -1 O CYS I 349 N VAL I 332
SHEET 4 AB9 4 CYS I 356 GLU I 363 -1 O THR I 357 N LEU I 348
SHEET 1 AC1 2 PHE I 384 ILE I 390 0
SHEET 2 AC1 2 PHE I 398 SER I 404 -1 O HIS I 400 N ARG I 388
SHEET 1 AC2 4 LYS I 427 ASP I 432 0
SHEET 2 AC2 4 LYS I 437 LEU I 446 -1 O LEU I 441 N LYS I 427
SHEET 3 AC2 4 ARG I 449 ALA I 455 -1 O GLN I 451 N SER I 442
SHEET 4 AC2 4 GLN I 464 CYS I 465 -1 O GLN I 464 N SER I 454
SHEET 1 AC3 4 SER I 478 PHE I 481 0
SHEET 2 AC3 4 PHE I 487 LYS I 491 -1 O LEU I 489 N SER I 480
SHEET 3 AC3 4 VAL I 500 ASN I 504 -1 O HIS I 503 N PHE I 488
SHEET 4 AC3 4 PHE I 512 GLU I 515 -1 O GLU I 515 N VAL I 500
SHEET 1 AC4 8 LYS I 531 GLU I 533 0
SHEET 2 AC4 8 MET I 546 LYS I 550 -1 O ILE I 548 N GLU I 533
SHEET 3 AC4 8 VAL I 594 CYS I 598 -1 O LYS I 597 N GLN I 547
SHEET 4 AC4 8 TYR I 560 VAL I 566 1 N LEU I 563 O VAL I 594
SHEET 5 AC4 8 ILE I 639 GLY I 648 1 O ASP I 640 N TYR I 560
SHEET 6 AC4 8 CYS I 673 LEU I 677 1 N CYS I 673 O VAL I 644
SHEET 7 AC4 8 GLN I 721 PRO I 727 1 O GLN I 721 N GLY I 674
SHEET 8 AC4 8 TYR I 752 TYR I 757 1 O GLN I 755 N HIS I 726
SHEET 1 AC5 2 ILE I 537 ILE I 539 0
SHEET 2 AC5 2 TYR I 542 LEU I 544 -1 O TYR I 542 N ILE I 539
SHEET 1 AC6 4 ARG B 51 TRP B 55 0
SHEET 2 AC6 4 LEU B 42 VAL B 47 -1 N ILE B 43 O THR B 54
SHEET 3 AC6 4 GLN B 82 PHE B 85 1 O TYR B 83 N VAL B 44
SHEET 4 AC6 4 TYR B 76 HIS B 77 -1 N HIS B 77 O GLN B 82
SHEET 1 AC7 2 VAL E 68 ASN E 70 0
SHEET 2 AC7 2 SER E 105 LYS E 107 -1 O VAL E 106 N VAL E 69
SHEET 1 AC8 2 LEU A 42 ILE A 43 0
SHEET 2 AC8 2 THR A 54 TRP A 55 -1 O THR A 54 N ILE A 43
SHEET 1 AC9 3 THR A 50 ARG A 51 0
SHEET 2 AC9 3 LEU A 45 VAL A 47 -1 N VAL A 47 O THR A 50
SHEET 3 AC9 3 TYR A 83 PHE A 85 1 O TYR A 83 N ASN A 46
SHEET 1 AD1 2 VAL L 103 ASN L 107 0
SHEET 2 AD1 2 THR L 112 ILE L 117 -1 O THR L 114 N LEU L 105
SHEET 1 AD2 4 ARG L 129 ILE L 132 0
SHEET 2 AD2 4 TYR L 138 GLU L 146 -1 O SER L 142 N ARG L 129
SHEET 3 AD2 4 THR L 154 LYS L 161 -1 O VAL L 158 N PHE L 141
SHEET 4 AD2 4 GLN L 168 SER L 169 -1 O GLN L 168 N LEU L 159
SHEET 1 AD3 2 LEU L 192 ILE L 195 0
SHEET 2 AD3 2 ILE L 200 CYS L 203 -1 O CYS L 203 N LEU L 192
SHEET 1 AD4 6 ASP L 305 GLU L 307 0
SHEET 2 AD4 6 SER L 291 GLY L 298 -1 N VAL L 296 O LEU L 306
SHEET 3 AD4 6 ARG L 250 ASN L 257 -1 N ASN L 257 O SER L 291
SHEET 4 AD4 6 ILE L 240 TRP L 244 -1 N TRP L 243 O ALA L 252
SHEET 5 AD4 6 ILE L 222 LEU L 226 -1 N GLY L 225 O ALA L 241
SHEET 6 AD4 6 ARG L 250 ASN L 257 -1 O ILE L 256 N TYR L 223
SHEET 1 AD5 2 ILE L 263 LEU L 266 0
SHEET 2 AD5 2 LYS L 278 HIS L 281 -1 O TYR L 280 N MET L 264
SHEET 1 AD6 4 TYR L 319 LYS L 325 0
SHEET 2 AD6 4 LYS L 331 ASN L 338 -1 O ALA L 333 N LYS L 325
SHEET 3 AD6 4 VAL L 343 ASP L 350 -1 O THR L 347 N VAL L 334
SHEET 4 AD6 4 CYS L 356 GLU L 363 -1 O THR L 357 N LEU L 348
SHEET 1 AD7 2 PHE L 384 ILE L 390 0
SHEET 2 AD7 2 PHE L 398 SER L 404 -1 O HIS L 400 N ARG L 388
SHEET 1 AD8 4 VAL L 425 ASP L 432 0
SHEET 2 AD8 4 LYS L 437 SER L 442 -1 O TYR L 439 N ALA L 430
SHEET 3 AD8 4 GLN L 451 ALA L 455 -1 O TYR L 453 N PHE L 440
SHEET 4 AD8 4 GLN L 464 CYS L 465 -1 O GLN L 464 N SER L 454
SHEET 1 AD9 4 SER L 478 PHE L 481 0
SHEET 2 AD9 4 PHE L 487 LYS L 491 -1 O LEU L 489 N SER L 480
SHEET 3 AD9 4 VAL L 500 ASN L 504 -1 O HIS L 503 N PHE L 488
SHEET 4 AD9 4 LYS L 510 GLU L 515 -1 O GLU L 515 N VAL L 500
SHEET 1 AE1 8 LYS L 531 TYR L 534 0
SHEET 2 AE1 8 MET L 546 LYS L 550 -1 O ILE L 548 N GLU L 533
SHEET 3 AE1 8 VAL L 595 CYS L 598 -1 O LYS L 597 N GLN L 547
SHEET 4 AE1 8 LEU L 562 VAL L 566 1 N VAL L 565 O VAL L 596
SHEET 5 AE1 8 VAL L 644 GLY L 648 1 O PHE L 647 N VAL L 566
SHEET 6 AE1 8 CYS L 673 LEU L 677 1 O CYS L 673 N VAL L 646
SHEET 7 AE1 8 GLN L 721 PRO L 727 1 O GLN L 721 N GLY L 674
SHEET 8 AE1 8 GLN L 755 TYR L 757 1 O GLN L 755 N ILE L 724
SHEET 1 AE2 2 ILE L 537 ILE L 539 0
SHEET 2 AE2 2 TYR L 542 LEU L 544 -1 O TYR L 542 N ILE L 539
SHEET 1 AE3 2 ARG K 104 ASN K 107 0
SHEET 2 AE3 2 THR K 112 VAL K 115 -1 O THR K 112 N ASN K 107
SHEET 1 AE4 4 ARG K 129 ILE K 132 0
SHEET 2 AE4 4 TYR K 138 TYR K 143 -1 O SER K 142 N ARG K 129
SHEET 3 AE4 4 TYR K 156 LYS K 161 -1 O TYR K 156 N TYR K 143
SHEET 4 AE4 4 GLN K 168 SER K 169 -1 O GLN K 168 N LEU K 159
SHEET 1 AE5 3 LEU K 192 ILE K 195 0
SHEET 2 AE5 3 ILE K 200 CYS K 203 -1 O CYS K 203 N LEU K 192
SHEET 3 AE5 3 ILE K 211 VAL K 214 -1 O VAL K 214 N ILE K 200
SHEET 1 AE6 3 ILE K 222 ASN K 224 0
SHEET 2 AE6 3 ARG K 250 ASN K 257 -1 O ILE K 256 N TYR K 223
SHEET 3 AE6 3 HIS K 242 TRP K 244 -1 N TRP K 243 O ALA K 252
SHEET 1 AE7 4 ILE K 222 ASN K 224 0
SHEET 2 AE7 4 ARG K 250 ASN K 257 -1 O ILE K 256 N TYR K 223
SHEET 3 AE7 4 SER K 291 GLY K 298 -1 O HIS K 295 N TYR K 253
SHEET 4 AE7 4 LEU K 306 MET K 308 -1 O MET K 308 N LEU K 294
SHEET 1 AE8 2 ILE K 263 LEU K 266 0
SHEET 2 AE8 2 LYS K 278 HIS K 281 -1 O TYR K 280 N MET K 264
SHEET 1 AE9 4 TYR K 319 TRP K 326 0
SHEET 2 AE9 4 LYS K 331 ASN K 338 -1 O ALA K 333 N LYS K 325
SHEET 3 AE9 4 VAL K 343 ASP K 350 -1 O CYS K 349 N VAL K 332
SHEET 4 AE9 4 CYS K 356 GLU K 363 -1 O THR K 357 N LEU K 348
SHEET 1 AF1 2 PHE K 384 ILE K 390 0
SHEET 2 AF1 2 PHE K 398 SER K 404 -1 O HIS K 400 N ARG K 388
SHEET 1 AF2 4 LYS K 427 ASP K 432 0
SHEET 2 AF2 4 LYS K 437 LEU K 446 -1 O LEU K 441 N LYS K 427
SHEET 3 AF2 4 ARG K 449 ALA K 455 -1 O GLN K 451 N SER K 442
SHEET 4 AF2 4 GLN K 464 CYS K 465 -1 O GLN K 464 N SER K 454
SHEET 1 AF3 4 SER K 478 PHE K 481 0
SHEET 2 AF3 4 PHE K 487 LYS K 491 -1 O LEU K 489 N SER K 480
SHEET 3 AF3 4 VAL K 500 ASN K 504 -1 O HIS K 503 N PHE K 488
SHEET 4 AF3 4 PHE K 512 GLU K 515 -1 O GLU K 515 N VAL K 500
SHEET 1 AF4 8 LYS K 531 GLU K 533 0
SHEET 2 AF4 8 MET K 546 LYS K 550 -1 O ILE K 548 N GLU K 533
SHEET 3 AF4 8 VAL K 594 CYS K 598 -1 O LYS K 597 N GLN K 547
SHEET 4 AF4 8 TYR K 560 VAL K 566 1 N LEU K 563 O VAL K 594
SHEET 5 AF4 8 ILE K 639 GLY K 648 1 O ASP K 640 N TYR K 560
SHEET 6 AF4 8 CYS K 673 LEU K 677 1 N CYS K 673 O VAL K 644
SHEET 7 AF4 8 GLN K 721 PRO K 727 1 O GLN K 721 N GLY K 674
SHEET 8 AF4 8 TYR K 752 TYR K 757 1 O GLN K 755 N HIS K 726
SHEET 1 AF5 2 ILE K 537 ILE K 539 0
SHEET 2 AF5 2 TYR K 542 LEU K 544 -1 O TYR K 542 N ILE K 539
SHEET 1 AF6 4 ARG D 51 TRP D 55 0
SHEET 2 AF6 4 LEU D 42 VAL D 47 -1 N ILE D 43 O THR D 54
SHEET 3 AF6 4 GLN D 82 PHE D 85 1 O TYR D 83 N VAL D 44
SHEET 4 AF6 4 TYR D 76 HIS D 77 -1 N HIS D 77 O GLN D 82
SHEET 1 AF7 2 VAL G 68 ASN G 70 0
SHEET 2 AF7 2 SER G 105 LYS G 107 -1 O VAL G 106 N VAL G 69
SHEET 1 AF8 2 LEU C 42 ILE C 43 0
SHEET 2 AF8 2 THR C 54 TRP C 55 -1 O THR C 54 N ILE C 43
SHEET 1 AF9 3 THR C 50 ARG C 51 0
SHEET 2 AF9 3 LEU C 45 VAL C 47 -1 N VAL C 47 O THR C 50
SHEET 3 AF9 3 TYR C 83 PHE C 85 1 O TYR C 83 N ASN C 46
SSBOND 1 CYS J 349 CYS J 356 1555 1555 2.03
SSBOND 2 CYS J 465 CYS J 468 1555 1555 2.03
SSBOND 3 CYS J 474 CYS J 492 1555 1555 2.03
SSBOND 4 CYS J 673 CYS J 784 1555 1555 2.03
SSBOND 5 CYS I 349 CYS I 356 1555 1555 2.03
SSBOND 6 CYS I 465 CYS I 468 1555 1555 2.04
SSBOND 7 CYS I 474 CYS I 492 1555 1555 2.03
SSBOND 8 CYS I 673 CYS I 784 1555 1555 2.03
SSBOND 9 CYS L 349 CYS L 356 1555 1555 2.03
SSBOND 10 CYS L 465 CYS L 468 1555 1555 2.03
SSBOND 11 CYS L 474 CYS L 492 1555 1555 2.03
SSBOND 12 CYS L 673 CYS L 784 1555 1555 2.03
SSBOND 13 CYS K 349 CYS K 356 1555 1555 2.03
SSBOND 14 CYS K 465 CYS K 468 1555 1555 2.04
SSBOND 15 CYS K 474 CYS K 492 1555 1555 2.03
SSBOND 16 CYS K 673 CYS K 784 1555 1555 2.03
CISPEP 1 GLY J 494 PRO J 495 0 0.79
CISPEP 2 GLY I 494 PRO I 495 0 -2.19
CISPEP 3 GLY L 494 PRO L 495 0 0.72
CISPEP 4 GLY K 494 PRO K 495 0 -2.24
CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1
ORIGX1 1.000000 0.000000 0.000000 0.00000
ORIGX2 0.000000 1.000000 0.000000 0.00000
ORIGX3 0.000000 0.000000 1.000000 0.00000
SCALE1 1.000000 0.000000 0.000000 0.00000
SCALE2 0.000000 1.000000 0.000000 0.00000
SCALE3 0.000000 0.000000 1.000000 0.00000
TER 6072 ILE J 787
TER 12166 ILE I 787
TER 13626 MET F 216
TER 17302 ASP B 495
TER 18769 MET E 216
TER 22453 ASP A 495
TER 28525 ILE L 787
TER 34619 ILE K 787
TER 36079 MET H 216
TER 39755 ASP D 495
TER 41222 MET G 216
TER 44906 ASP C 495
MASTER 354 0 0 186 186 0 0 644894 12 32 444
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