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HEADER IMMUNE SYSTEM, HYDROLASE 28-JUL-20 7JKQ
TITLE HUMAN DPP9-CARD8 COMPLEX
COMPND MOL_ID: 1;
COMPND 2 MOLECULE: DIPEPTIDYL PEPTIDASE 9;
COMPND 3 CHAIN: A, D;
COMPND 4 SYNONYM: DP9,DIPEPTIDYL PEPTIDASE IV-RELATED PROTEIN 2,DPRP-2,
COMPND 5 DIPEPTIDYL PEPTIDASE IX,DPP IX,DIPEPTIDYL PEPTIDASE-LIKE PROTEIN 9,
COMPND 6 DPLP9,DPP9;
COMPND 7 EC: 3.4.14.5;
COMPND 8 ENGINEERED: YES;
COMPND 9 MOL_ID: 2;
COMPND 10 MOLECULE: CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 8;
COMPND 11 CHAIN: B, C;
COMPND 12 SYNONYM: APOPTOTIC PROTEIN NDPP1,CARD-INHIBITOR OF NF-KAPPA-B-
COMPND 13 ACTIVATING LIGAND,CARDINAL,DACAR,TUMOR UP-REGULATED CARD-CONTAINING
COMPND 14 ANTAGONIST OF CASP9,TUCAN,CARD8;
COMPND 15 ENGINEERED: YES
SOURCE MOL_ID: 1;
SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 3 ORGANISM_COMMON: HUMAN;
SOURCE 4 ORGANISM_TAXID: 9606;
SOURCE 5 GENE: DPP9, DPRP2;
SOURCE 6 EXPRESSION_SYSTEM: HOMO SAPIENS;
SOURCE 7 EXPRESSION_SYSTEM_COMMON: HUMAN;
SOURCE 8 EXPRESSION_SYSTEM_TAXID: 9606;
SOURCE 9 EXPRESSION_SYSTEM_CELL_LINE: HEK293;
SOURCE 10 MOL_ID: 2;
SOURCE 11 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 12 ORGANISM_COMMON: HUMAN;
SOURCE 13 ORGANISM_TAXID: 9606;
SOURCE 14 GENE: CARD8, KIAA0955, NDPP1;
SOURCE 15 EXPRESSION_SYSTEM: HOMO SAPIENS;
SOURCE 16 EXPRESSION_SYSTEM_COMMON: HUMAN;
SOURCE 17 EXPRESSION_SYSTEM_TAXID: 9606;
SOURCE 18 EXPRESSION_SYSTEM_CELL_LINE: HEK293
KEYWDS CARD8, DPP9, INFLAMMASOME, VAL-BOROPRO (VBP), TALABOSTAT, INNATE
KEYWDS 2 IMMUNITY, IMMUNE SYSTEM, HYDROLASE
EXPDTA ELECTRON MICROSCOPY
AUTHOR H.SHARIF,L.R.HOLLINGSWORTH
REVDAT 1 26-MAY-21 7JKQ 0
JRNL AUTH H.SHARIF,L.R.HOLLINGSWORTH
JRNL TITL HUMAN DPP9-CARD8 COMPLEX
JRNL REF TO BE PUBLISHED
JRNL REFN
REMARK 2
REMARK 2 RESOLUTION. 3.30 ANGSTROMS.
REMARK 3
REMARK 3 REFINEMENT.
REMARK 3 SOFTWARE PACKAGES : SERIALEM, CTFFIND, PHENIX, RELION,
REMARK 3 RELION, RELION, RELION, PHENIX
REMARK 3 RECONSTRUCTION SCHEMA : FOURIER SPACE
REMARK 3
REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT
REMARK 3 PDB ENTRY : 6EOQ
REMARK 3 REFINEMENT SPACE : NULL
REMARK 3 REFINEMENT PROTOCOL : OTHER
REMARK 3 REFINEMENT TARGET : NULL
REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL
REMARK 3
REMARK 3 FITTING PROCEDURE : NULL
REMARK 3
REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS
REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.300
REMARK 3 NUMBER OF PARTICLES : 120998
REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE
REMARK 3 CORRECTION
REMARK 3
REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL
REMARK 3
REMARK 3 OTHER DETAILS: NULL
REMARK 4
REMARK 4 7JKQ COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 29-JUL-20.
REMARK 100 THE DEPOSITION ID IS D_1000250996.
REMARK 245
REMARK 245 EXPERIMENTAL DETAILS
REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE
REMARK 245 SPECIMEN TYPE : NULL
REMARK 245
REMARK 245 ELECTRON MICROSCOPE SAMPLE
REMARK 245 SAMPLE TYPE : PARTICLE
REMARK 245 PARTICLE TYPE : POINT
REMARK 245 NAME OF SAMPLE : DPP9-CARD8 COMPLEX
REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 0.50
REMARK 245 SAMPLE SUPPORT DETAILS : NULL
REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL
REMARK 245 SAMPLE BUFFER : NULL
REMARK 245 PH : 7.50
REMARK 245 SAMPLE DETAILS : NULL
REMARK 245
REMARK 245 DATA ACQUISITION
REMARK 245 DATE OF EXPERIMENT : NULL
REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : 2488
REMARK 245 TEMPERATURE (KELVIN) : NULL
REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS
REMARK 245 DETECTOR TYPE : GATAN K3 BIOQUANTUM (6K X
REMARK 245 4K)
REMARK 245 MINIMUM DEFOCUS (NM) : -800.00
REMARK 245 MAXIMUM DEFOCUS (NM) : 2200.00
REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 NOMINAL CS : 2.70
REMARK 245 IMAGING MODE : OTHER
REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 6499.00
REMARK 245 ILLUMINATION MODE : SPOT SCAN
REMARK 245 NOMINAL MAGNIFICATION : NULL
REMARK 245 CALIBRATED MAGNIFICATION : 10500
REMARK 245 SOURCE : OTHER
REMARK 245 ACCELERATION VOLTAGE (KV) : 300
REMARK 245 IMAGING DETAILS : NULL
REMARK 247
REMARK 247 ELECTRON MICROSCOPY
REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON
REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE
REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES
REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION
REMARK 247 OF THE STRUCTURE FACTORS.
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465 M RES C SSSEQI
REMARK 465 MET A 1
REMARK 465 ALA A 2
REMARK 465 THR A 3
REMARK 465 THR A 4
REMARK 465 GLY A 5
REMARK 465 THR A 6
REMARK 465 PRO A 7
REMARK 465 THR A 8
REMARK 465 ALA A 9
REMARK 465 ASP A 10
REMARK 465 ARG A 11
REMARK 465 GLY A 12
REMARK 465 ASP A 13
REMARK 465 ALA A 14
REMARK 465 ALA A 15
REMARK 465 ALA A 16
REMARK 465 THR A 17
REMARK 465 HIS A 117
REMARK 465 HIS A 118
REMARK 465 GLY A 119
REMARK 465 VAL A 120
REMARK 465 TYR A 121
REMARK 465 SER A 122
REMARK 465 ARG A 123
REMARK 465 GLU A 124
REMARK 465 GLU A 125
REMARK 465 GLU A 126
REMARK 465 LEU A 127
REMARK 465 LEU A 128
REMARK 465 ARG A 129
REMARK 465 GLU A 130
REMARK 465 ARG A 131
REMARK 465 LYS A 132
REMARK 465 ARG A 133
REMARK 465 LEU A 134
REMARK 465 GLY A 135
REMARK 465 MET B 1
REMARK 465 GLU B 2
REMARK 465 LYS B 3
REMARK 465 LYS B 4
REMARK 465 GLU B 5
REMARK 465 CYS B 6
REMARK 465 PRO B 7
REMARK 465 GLU B 8
REMARK 465 LYS B 9
REMARK 465 SER B 10
REMARK 465 SER B 11
REMARK 465 SER B 12
REMARK 465 SER B 13
REMARK 465 GLU B 14
REMARK 465 GLU B 15
REMARK 465 GLU B 16
REMARK 465 LEU B 17
REMARK 465 PRO B 18
REMARK 465 ARG B 19
REMARK 465 ARG B 20
REMARK 465 ASP B 21
REMARK 465 SER B 22
REMARK 465 GLY B 23
REMARK 465 SER B 24
REMARK 465 SER B 25
REMARK 465 ARG B 26
REMARK 465 ASN B 27
REMARK 465 ILE B 28
REMARK 465 ASP B 29
REMARK 465 ALA B 30
REMARK 465 SER B 31
REMARK 465 LYS B 32
REMARK 465 LEU B 33
REMARK 465 ILE B 34
REMARK 465 ARG B 35
REMARK 465 LEU B 36
REMARK 465 GLN B 37
REMARK 465 GLY B 38
REMARK 465 SER B 39
REMARK 465 ARG B 40
REMARK 465 LYS B 41
REMARK 465 LEU B 42
REMARK 465 LEU B 43
REMARK 465 VAL B 44
REMARK 465 ASP B 45
REMARK 465 ASN B 46
REMARK 465 SER B 47
REMARK 465 ILE B 48
REMARK 465 ARG B 49
REMARK 465 GLU B 50
REMARK 465 LEU B 51
REMARK 465 GLN B 52
REMARK 465 TYR B 53
REMARK 465 THR B 54
REMARK 465 LYS B 55
REMARK 465 THR B 56
REMARK 465 GLY B 57
REMARK 465 ILE B 58
REMARK 465 PHE B 59
REMARK 465 PHE B 60
REMARK 465 GLN B 61
REMARK 465 ALA B 62
REMARK 465 GLU B 63
REMARK 465 ALA B 64
REMARK 465 CYS B 65
REMARK 465 VAL B 66
REMARK 465 THR B 67
REMARK 465 ASN B 68
REMARK 465 ASP B 69
REMARK 465 THR B 70
REMARK 465 VAL B 71
REMARK 465 TYR B 72
REMARK 465 ARG B 73
REMARK 465 GLU B 74
REMARK 465 LEU B 75
REMARK 465 PRO B 76
REMARK 465 CYS B 77
REMARK 465 VAL B 78
REMARK 465 SER B 79
REMARK 465 GLU B 80
REMARK 465 THR B 81
REMARK 465 LEU B 82
REMARK 465 CYS B 83
REMARK 465 ASP B 84
REMARK 465 ILE B 85
REMARK 465 SER B 86
REMARK 465 HIS B 87
REMARK 465 PHE B 88
REMARK 465 PHE B 89
REMARK 465 GLN B 90
REMARK 465 GLU B 91
REMARK 465 ASP B 92
REMARK 465 ASP B 93
REMARK 465 GLU B 94
REMARK 465 THR B 95
REMARK 465 GLU B 96
REMARK 465 ALA B 97
REMARK 465 GLU B 98
REMARK 465 PRO B 99
REMARK 465 LEU B 100
REMARK 465 LEU B 101
REMARK 465 PHE B 102
REMARK 465 ARG B 103
REMARK 465 ALA B 104
REMARK 465 VAL B 105
REMARK 465 PRO B 106
REMARK 465 GLU B 107
REMARK 465 CYS B 108
REMARK 465 GLN B 109
REMARK 465 LEU B 110
REMARK 465 SER B 111
REMARK 465 GLY B 112
REMARK 465 GLY B 113
REMARK 465 ASP B 114
REMARK 465 ILE B 115
REMARK 465 PRO B 116
REMARK 465 SER B 117
REMARK 465 VAL B 118
REMARK 465 SER B 119
REMARK 465 GLU B 120
REMARK 465 GLU B 121
REMARK 465 GLN B 122
REMARK 465 GLU B 123
REMARK 465 SER B 124
REMARK 465 SER B 125
REMARK 465 GLU B 126
REMARK 465 GLY B 127
REMARK 465 GLN B 128
REMARK 465 ASP B 129
REMARK 465 SER B 130
REMARK 465 GLY B 131
REMARK 465 ASP B 132
REMARK 465 ILE B 133
REMARK 465 CYS B 134
REMARK 465 SER B 135
REMARK 465 GLU B 136
REMARK 465 GLU B 137
REMARK 465 ASN B 138
REMARK 465 GLN B 139
REMARK 465 ILE B 140
REMARK 465 VAL B 141
REMARK 465 SER B 142
REMARK 465 SER B 143
REMARK 465 TYR B 144
REMARK 465 ALA B 145
REMARK 465 SER B 146
REMARK 465 LYS B 147
REMARK 465 VAL B 148
REMARK 465 CYS B 149
REMARK 465 PHE B 150
REMARK 465 GLU B 151
REMARK 465 ILE B 152
REMARK 465 GLU B 153
REMARK 465 GLU B 154
REMARK 465 ASP B 155
REMARK 465 TYR B 156
REMARK 465 LYS B 157
REMARK 465 ASN B 158
REMARK 465 ARG B 159
REMARK 465 GLN B 160
REMARK 465 PHE B 161
REMARK 465 LEU B 162
REMARK 465 GLY B 163
REMARK 465 PRO B 164
REMARK 465 GLU B 165
REMARK 465 PHE B 296
REMARK 465 SER B 297
REMARK 465 LEU B 298
REMARK 465 MET B 299
REMARK 465 GLY B 300
REMARK 465 ILE B 301
REMARK 465 LEU B 302
REMARK 465 LEU B 303
REMARK 465 PRO B 446
REMARK 465 PRO B 447
REMARK 465 PHE B 448
REMARK 465 SER B 449
REMARK 465 GLY B 450
REMARK 465 ALA B 451
REMARK 465 ALA B 452
REMARK 465 PHE B 453
REMARK 465 VAL B 454
REMARK 465 LYS B 455
REMARK 465 GLU B 456
REMARK 465 ASN B 457
REMARK 465 HIS B 458
REMARK 465 ARG B 459
REMARK 465 GLN B 460
REMARK 465 LEU B 461
REMARK 465 GLN B 462
REMARK 465 ALA B 463
REMARK 465 ARG B 464
REMARK 465 MET B 465
REMARK 465 GLY B 466
REMARK 465 ASP B 467
REMARK 465 LEU B 468
REMARK 465 LYS B 469
REMARK 465 GLY B 470
REMARK 465 VAL B 471
REMARK 465 LEU B 472
REMARK 465 ASP B 473
REMARK 465 ASP B 474
REMARK 465 LEU B 475
REMARK 465 GLN B 476
REMARK 465 ASP B 477
REMARK 465 ASN B 478
REMARK 465 GLU B 479
REMARK 465 VAL B 480
REMARK 465 LEU B 481
REMARK 465 THR B 482
REMARK 465 GLU B 483
REMARK 465 ASN B 484
REMARK 465 GLU B 485
REMARK 465 LYS B 486
REMARK 465 GLU B 487
REMARK 465 LEU B 488
REMARK 465 VAL B 489
REMARK 465 GLU B 490
REMARK 465 GLN B 491
REMARK 465 GLU B 492
REMARK 465 LYS B 493
REMARK 465 THR B 494
REMARK 465 ARG B 495
REMARK 465 GLN B 496
REMARK 465 SER B 497
REMARK 465 LYS B 498
REMARK 465 ASN B 499
REMARK 465 GLU B 500
REMARK 465 ALA B 501
REMARK 465 LEU B 502
REMARK 465 LEU B 503
REMARK 465 SER B 504
REMARK 465 MET B 505
REMARK 465 VAL B 506
REMARK 465 GLU B 507
REMARK 465 LYS B 508
REMARK 465 LYS B 509
REMARK 465 GLY B 510
REMARK 465 ASP B 511
REMARK 465 LEU B 512
REMARK 465 ALA B 513
REMARK 465 LEU B 514
REMARK 465 ASP B 515
REMARK 465 VAL B 516
REMARK 465 LEU B 517
REMARK 465 PHE B 518
REMARK 465 ARG B 519
REMARK 465 SER B 520
REMARK 465 ILE B 521
REMARK 465 SER B 522
REMARK 465 GLU B 523
REMARK 465 ARG B 524
REMARK 465 ASP B 525
REMARK 465 PRO B 526
REMARK 465 TYR B 527
REMARK 465 LEU B 528
REMARK 465 VAL B 529
REMARK 465 SER B 530
REMARK 465 TYR B 531
REMARK 465 LEU B 532
REMARK 465 ARG B 533
REMARK 465 GLN B 534
REMARK 465 GLN B 535
REMARK 465 ASN B 536
REMARK 465 LEU B 537
REMARK 465 MET C 1
REMARK 465 GLU C 2
REMARK 465 LYS C 3
REMARK 465 LYS C 4
REMARK 465 GLU C 5
REMARK 465 CYS C 6
REMARK 465 PRO C 7
REMARK 465 GLU C 8
REMARK 465 LYS C 9
REMARK 465 SER C 10
REMARK 465 SER C 11
REMARK 465 SER C 12
REMARK 465 SER C 13
REMARK 465 GLU C 14
REMARK 465 GLU C 15
REMARK 465 GLU C 16
REMARK 465 LEU C 17
REMARK 465 PRO C 18
REMARK 465 ARG C 19
REMARK 465 ARG C 20
REMARK 465 ASP C 21
REMARK 465 SER C 22
REMARK 465 GLY C 23
REMARK 465 SER C 24
REMARK 465 SER C 25
REMARK 465 ARG C 26
REMARK 465 ASN C 27
REMARK 465 ILE C 28
REMARK 465 ASP C 29
REMARK 465 ALA C 30
REMARK 465 SER C 31
REMARK 465 LYS C 32
REMARK 465 LEU C 33
REMARK 465 ILE C 34
REMARK 465 ARG C 35
REMARK 465 LEU C 36
REMARK 465 GLN C 37
REMARK 465 GLY C 38
REMARK 465 SER C 39
REMARK 465 ARG C 40
REMARK 465 LYS C 41
REMARK 465 LEU C 42
REMARK 465 LEU C 43
REMARK 465 VAL C 44
REMARK 465 ASP C 45
REMARK 465 ASN C 46
REMARK 465 SER C 47
REMARK 465 ILE C 48
REMARK 465 ARG C 49
REMARK 465 GLU C 50
REMARK 465 LEU C 51
REMARK 465 GLN C 52
REMARK 465 TYR C 53
REMARK 465 THR C 54
REMARK 465 LYS C 55
REMARK 465 THR C 56
REMARK 465 GLY C 57
REMARK 465 ILE C 58
REMARK 465 PHE C 59
REMARK 465 PHE C 60
REMARK 465 GLN C 61
REMARK 465 ALA C 62
REMARK 465 GLU C 63
REMARK 465 ALA C 64
REMARK 465 CYS C 65
REMARK 465 VAL C 66
REMARK 465 THR C 67
REMARK 465 ASN C 68
REMARK 465 ASP C 69
REMARK 465 THR C 70
REMARK 465 VAL C 71
REMARK 465 TYR C 72
REMARK 465 ARG C 73
REMARK 465 GLU C 74
REMARK 465 LEU C 75
REMARK 465 PRO C 76
REMARK 465 CYS C 77
REMARK 465 VAL C 78
REMARK 465 SER C 79
REMARK 465 GLU C 80
REMARK 465 THR C 81
REMARK 465 LEU C 82
REMARK 465 CYS C 83
REMARK 465 ASP C 84
REMARK 465 ILE C 85
REMARK 465 SER C 86
REMARK 465 HIS C 87
REMARK 465 PHE C 88
REMARK 465 PHE C 89
REMARK 465 GLN C 90
REMARK 465 GLU C 91
REMARK 465 ASP C 92
REMARK 465 ASP C 93
REMARK 465 GLU C 94
REMARK 465 THR C 95
REMARK 465 GLU C 96
REMARK 465 ALA C 97
REMARK 465 GLU C 98
REMARK 465 PRO C 99
REMARK 465 LEU C 100
REMARK 465 LEU C 101
REMARK 465 PHE C 102
REMARK 465 ARG C 103
REMARK 465 ALA C 104
REMARK 465 VAL C 105
REMARK 465 PRO C 106
REMARK 465 GLU C 107
REMARK 465 CYS C 108
REMARK 465 GLN C 109
REMARK 465 LEU C 110
REMARK 465 SER C 111
REMARK 465 GLY C 112
REMARK 465 GLY C 113
REMARK 465 ASP C 114
REMARK 465 ILE C 115
REMARK 465 PRO C 116
REMARK 465 SER C 117
REMARK 465 VAL C 118
REMARK 465 SER C 119
REMARK 465 GLU C 120
REMARK 465 GLU C 121
REMARK 465 GLN C 122
REMARK 465 GLU C 123
REMARK 465 SER C 124
REMARK 465 SER C 125
REMARK 465 GLU C 126
REMARK 465 GLY C 127
REMARK 465 GLN C 128
REMARK 465 ASP C 129
REMARK 465 SER C 130
REMARK 465 GLY C 131
REMARK 465 ASP C 132
REMARK 465 ILE C 133
REMARK 465 CYS C 134
REMARK 465 SER C 135
REMARK 465 GLU C 136
REMARK 465 GLU C 137
REMARK 465 ASN C 138
REMARK 465 GLN C 139
REMARK 465 ILE C 140
REMARK 465 VAL C 141
REMARK 465 SER C 142
REMARK 465 SER C 143
REMARK 465 TYR C 144
REMARK 465 ALA C 145
REMARK 465 SER C 146
REMARK 465 LYS C 147
REMARK 465 VAL C 148
REMARK 465 CYS C 149
REMARK 465 PHE C 150
REMARK 465 GLU C 151
REMARK 465 ILE C 152
REMARK 465 GLU C 153
REMARK 465 GLU C 154
REMARK 465 ASP C 155
REMARK 465 TYR C 156
REMARK 465 LYS C 157
REMARK 465 ASN C 158
REMARK 465 ARG C 159
REMARK 465 GLN C 160
REMARK 465 PHE C 161
REMARK 465 LEU C 162
REMARK 465 GLY C 163
REMARK 465 PRO C 164
REMARK 465 GLU C 165
REMARK 465 GLY C 166
REMARK 465 ASN C 167
REMARK 465 VAL C 168
REMARK 465 ASP C 169
REMARK 465 VAL C 170
REMARK 465 GLU C 171
REMARK 465 LEU C 172
REMARK 465 ILE C 173
REMARK 465 ASP C 174
REMARK 465 LYS C 175
REMARK 465 SER C 176
REMARK 465 THR C 177
REMARK 465 ASN C 178
REMARK 465 ARG C 179
REMARK 465 TYR C 180
REMARK 465 SER C 181
REMARK 465 VAL C 182
REMARK 465 TRP C 183
REMARK 465 PHE C 184
REMARK 465 PRO C 185
REMARK 465 THR C 186
REMARK 465 ALA C 187
REMARK 465 GLY C 188
REMARK 465 TRP C 189
REMARK 465 TYR C 190
REMARK 465 LEU C 191
REMARK 465 TRP C 192
REMARK 465 SER C 193
REMARK 465 ALA C 194
REMARK 465 THR C 195
REMARK 465 GLY C 196
REMARK 465 LEU C 197
REMARK 465 GLY C 198
REMARK 465 PHE C 199
REMARK 465 LEU C 200
REMARK 465 VAL C 201
REMARK 465 ARG C 202
REMARK 465 ASP C 203
REMARK 465 GLU C 204
REMARK 465 VAL C 205
REMARK 465 THR C 206
REMARK 465 VAL C 207
REMARK 465 THR C 208
REMARK 465 ILE C 209
REMARK 465 ALA C 210
REMARK 465 PHE C 211
REMARK 465 GLY C 212
REMARK 465 SER C 213
REMARK 465 TRP C 214
REMARK 465 SER C 215
REMARK 465 GLN C 216
REMARK 465 HIS C 217
REMARK 465 LEU C 218
REMARK 465 ALA C 219
REMARK 465 LEU C 220
REMARK 465 ASP C 221
REMARK 465 LEU C 222
REMARK 465 GLN C 223
REMARK 465 HIS C 224
REMARK 465 HIS C 225
REMARK 465 GLU C 226
REMARK 465 GLN C 227
REMARK 465 TRP C 228
REMARK 465 LEU C 229
REMARK 465 VAL C 230
REMARK 465 GLY C 231
REMARK 465 GLY C 232
REMARK 465 PRO C 233
REMARK 465 LEU C 234
REMARK 465 PHE C 235
REMARK 465 ASP C 236
REMARK 465 VAL C 237
REMARK 465 THR C 238
REMARK 465 ALA C 239
REMARK 465 GLU C 240
REMARK 465 PRO C 241
REMARK 465 GLU C 242
REMARK 465 GLU C 243
REMARK 465 ALA C 244
REMARK 465 VAL C 245
REMARK 465 ALA C 246
REMARK 465 GLU C 247
REMARK 465 ILE C 248
REMARK 465 HIS C 249
REMARK 465 LEU C 250
REMARK 465 PRO C 251
REMARK 465 HIS C 252
REMARK 465 PHE C 253
REMARK 465 ILE C 254
REMARK 465 SER C 255
REMARK 465 LEU C 256
REMARK 465 GLN C 257
REMARK 465 ALA C 258
REMARK 465 GLY C 259
REMARK 465 GLU C 260
REMARK 465 VAL C 261
REMARK 465 ASP C 262
REMARK 465 VAL C 263
REMARK 465 SER C 264
REMARK 465 TRP C 265
REMARK 465 PHE C 266
REMARK 465 LEU C 267
REMARK 465 VAL C 268
REMARK 465 ALA C 269
REMARK 465 HIS C 270
REMARK 465 PHE C 271
REMARK 465 LYS C 272
REMARK 465 ASN C 273
REMARK 465 GLU C 274
REMARK 465 GLY C 275
REMARK 465 MET C 276
REMARK 465 VAL C 277
REMARK 465 LEU C 278
REMARK 465 GLU C 279
REMARK 465 HIS C 280
REMARK 465 PRO C 281
REMARK 465 ALA C 282
REMARK 465 ARG C 283
REMARK 465 VAL C 284
REMARK 465 GLU C 285
REMARK 465 PRO C 286
REMARK 465 PHE C 287
REMARK 465 TYR C 288
REMARK 465 ALA C 289
REMARK 465 VAL C 290
REMARK 465 LEU C 291
REMARK 465 GLU C 292
REMARK 465 SER C 293
REMARK 465 PRO C 294
REMARK 465 SER C 295
REMARK 465 PHE C 296
REMARK 465 SER C 297
REMARK 465 LEU C 298
REMARK 465 MET C 299
REMARK 465 GLY C 300
REMARK 465 ILE C 301
REMARK 465 LEU C 302
REMARK 465 LEU C 303
REMARK 465 ARG C 304
REMARK 465 ILE C 305
REMARK 465 ALA C 306
REMARK 465 SER C 307
REMARK 465 GLY C 308
REMARK 465 THR C 309
REMARK 465 ARG C 310
REMARK 465 LEU C 311
REMARK 465 SER C 312
REMARK 465 ILE C 313
REMARK 465 PRO C 314
REMARK 465 ILE C 315
REMARK 465 THR C 316
REMARK 465 SER C 317
REMARK 465 ASN C 318
REMARK 465 THR C 319
REMARK 465 PRO C 447
REMARK 465 PHE C 448
REMARK 465 SER C 449
REMARK 465 GLY C 450
REMARK 465 ALA C 451
REMARK 465 ALA C 452
REMARK 465 PHE C 453
REMARK 465 VAL C 454
REMARK 465 LYS C 455
REMARK 465 GLU C 456
REMARK 465 ASN C 457
REMARK 465 HIS C 458
REMARK 465 ARG C 459
REMARK 465 GLN C 460
REMARK 465 LEU C 461
REMARK 465 GLN C 462
REMARK 465 ALA C 463
REMARK 465 ARG C 464
REMARK 465 MET C 465
REMARK 465 GLY C 466
REMARK 465 ASP C 467
REMARK 465 LEU C 468
REMARK 465 LYS C 469
REMARK 465 GLY C 470
REMARK 465 VAL C 471
REMARK 465 LEU C 472
REMARK 465 ASP C 473
REMARK 465 ASP C 474
REMARK 465 LEU C 475
REMARK 465 GLN C 476
REMARK 465 ASP C 477
REMARK 465 ASN C 478
REMARK 465 GLU C 479
REMARK 465 VAL C 480
REMARK 465 LEU C 481
REMARK 465 THR C 482
REMARK 465 GLU C 483
REMARK 465 ASN C 484
REMARK 465 GLU C 485
REMARK 465 LYS C 486
REMARK 465 GLU C 487
REMARK 465 LEU C 488
REMARK 465 VAL C 489
REMARK 465 GLU C 490
REMARK 465 GLN C 491
REMARK 465 GLU C 492
REMARK 465 LYS C 493
REMARK 465 THR C 494
REMARK 465 ARG C 495
REMARK 465 GLN C 496
REMARK 465 SER C 497
REMARK 465 LYS C 498
REMARK 465 ASN C 499
REMARK 465 GLU C 500
REMARK 465 ALA C 501
REMARK 465 LEU C 502
REMARK 465 LEU C 503
REMARK 465 SER C 504
REMARK 465 MET C 505
REMARK 465 VAL C 506
REMARK 465 GLU C 507
REMARK 465 LYS C 508
REMARK 465 LYS C 509
REMARK 465 GLY C 510
REMARK 465 ASP C 511
REMARK 465 LEU C 512
REMARK 465 ALA C 513
REMARK 465 LEU C 514
REMARK 465 ASP C 515
REMARK 465 VAL C 516
REMARK 465 LEU C 517
REMARK 465 PHE C 518
REMARK 465 ARG C 519
REMARK 465 SER C 520
REMARK 465 ILE C 521
REMARK 465 SER C 522
REMARK 465 GLU C 523
REMARK 465 ARG C 524
REMARK 465 ASP C 525
REMARK 465 PRO C 526
REMARK 465 TYR C 527
REMARK 465 LEU C 528
REMARK 465 VAL C 529
REMARK 465 SER C 530
REMARK 465 TYR C 531
REMARK 465 LEU C 532
REMARK 465 ARG C 533
REMARK 465 GLN C 534
REMARK 465 GLN C 535
REMARK 465 ASN C 536
REMARK 465 LEU C 537
REMARK 465 MET D 1
REMARK 465 ALA D 2
REMARK 465 THR D 3
REMARK 465 THR D 4
REMARK 465 GLY D 5
REMARK 465 THR D 6
REMARK 465 PRO D 7
REMARK 465 THR D 8
REMARK 465 ALA D 9
REMARK 465 ASP D 10
REMARK 465 ARG D 11
REMARK 465 GLY D 12
REMARK 465 ASP D 13
REMARK 465 ALA D 14
REMARK 465 ALA D 15
REMARK 465 ALA D 16
REMARK 465 THR D 17
REMARK 465 THR D 115
REMARK 465 PRO D 116
REMARK 465 HIS D 117
REMARK 465 HIS D 118
REMARK 465 GLY D 119
REMARK 465 VAL D 120
REMARK 465 TYR D 121
REMARK 465 SER D 122
REMARK 465 ARG D 123
REMARK 465 GLU D 124
REMARK 465 GLU D 125
REMARK 465 GLU D 126
REMARK 465 LEU D 127
REMARK 465 LEU D 128
REMARK 465 ARG D 129
REMARK 465 GLU D 130
REMARK 465 ARG D 131
REMARK 465 LYS D 132
REMARK 465 ARG D 133
REMARK 465 LEU D 134
REMARK 465 GLY D 135
REMARK 465 VAL D 136
REMARK 465 PHE D 137
REMARK 465 GLY D 138
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470 M RES CSSEQI ATOMS
REMARK 470 ASP A 18 CG OD1 OD2
REMARK 470 GLU A 64 CG CD OE1 OE2
REMARK 470 LEU A 233 CG CD1 CD2
REMARK 470 ASP A 234 CG OD1 OD2
REMARK 470 GLU A 265 CG CD OE1 OE2
REMARK 470 PHE B 211 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 ARG B 304 CG CD NE CZ NH1 NH2
REMARK 470 ILE B 305 CG1 CG2 CD1
REMARK 470 ILE B 315 CG1 CG2 CD1
REMARK 470 ASP D 18 CG OD1 OD2
REMARK 470 GLU D 64 CG CD OE1 OE2
REMARK 470 ILE D 139 CG1 CG2 CD1
REMARK 470 LEU D 233 CG CD1 CD2
REMARK 470 ASP D 234 CG OD1 OD2
REMARK 470 GLU D 265 CG CD OE1 OE2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3
REMARK 500 LEU A 378 CB - CG - CD1 ANGL. DEV. = -11.6 DEGREES
REMARK 500 LEU A 803 CA - CB - CG ANGL. DEV. = 17.0 DEGREES
REMARK 500 ASP B 221 CB - CG - OD2 ANGL. DEV. = 6.9 DEGREES
REMARK 500 LEU C 334 CA - CB - CG ANGL. DEV. = 14.6 DEGREES
REMARK 500 PRO D 198 C - N - CD ANGL. DEV. = -12.7 DEGREES
REMARK 500 LYS D 336 N - CA - CB ANGL. DEV. = -10.8 DEGREES
REMARK 500 LEU D 664 CA - CB - CG ANGL. DEV. = -14.4 DEGREES
REMARK 500 ASP D 763 CB - CG - OD2 ANGL. DEV. = 6.2 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500 M RES CSSEQI PSI PHI
REMARK 500 TYR A 79 -9.18 74.10
REMARK 500 ALA A 155 -157.06 -141.15
REMARK 500 SER A 156 93.86 -65.10
REMARK 500 ASP A 164 116.30 -160.95
REMARK 500 ASP A 190 72.02 50.28
REMARK 500 GLU A 268 -52.26 -125.29
REMARK 500 ALA A 316 149.69 -170.98
REMARK 500 GLN A 334 120.61 -170.01
REMARK 500 TRP A 375 49.63 -140.31
REMARK 500 VAL A 419 -74.22 -105.95
REMARK 500 PHE A 427 -68.82 -122.48
REMARK 500 TYR A 428 101.65 45.32
REMARK 500 ASP A 437 -162.42 -160.58
REMARK 500 GLU A 438 71.28 61.10
REMARK 500 GLU A 493 38.67 -98.32
REMARK 500 GLN A 696 34.05 -144.74
REMARK 500 SER A 730 -57.38 -25.45
REMARK 500 ASN A 777 63.91 -103.25
REMARK 500 ASN A 810 -66.34 -95.85
REMARK 500 ARG A 839 -74.76 -84.01
REMARK 500 HIS A 840 -55.33 -122.28
REMARK 500 TYR B 190 71.93 58.18
REMARK 500 ASP B 203 -168.74 -161.14
REMARK 500 LEU B 220 -7.34 70.81
REMARK 500 GLU B 242 65.06 60.67
REMARK 500 SER B 293 74.78 53.07
REMARK 500 ARG B 310 118.37 -162.70
REMARK 500 TYR B 322 70.49 58.01
REMARK 500 TYR B 335 47.59 38.55
REMARK 500 SER B 372 40.04 -104.37
REMARK 500 TYR B 374 -167.52 -124.69
REMARK 500 LYS B 390 -166.64 -120.91
REMARK 500 ARG B 394 49.17 38.83
REMARK 500 PHE B 405 -30.51 -135.88
REMARK 500 LEU B 416 -1.19 69.07
REMARK 500 ALA B 442 40.28 -104.01
REMARK 500 LYS C 404 49.60 -89.66
REMARK 500 LEU C 416 -5.37 69.59
REMARK 500 ASP D 63 -30.41 -135.75
REMARK 500 ASP D 110 62.89 -100.38
REMARK 500 SER D 156 -15.85 69.94
REMARK 500 ASN D 157 -17.78 -145.17
REMARK 500 GLU D 268 -56.35 -123.81
REMARK 500 GLU D 282 39.36 -95.81
REMARK 500 ALA D 316 148.75 -171.51
REMARK 500 TRP D 375 51.32 -140.58
REMARK 500 VAL D 419 -70.90 -104.58
REMARK 500 GLN D 432 40.55 -102.88
REMARK 500 GLU D 436 64.39 -69.11
REMARK 500 ASP D 437 -168.56 -169.85
REMARK 500
REMARK 500 THIS ENTRY HAS 56 RAMACHANDRAN OUTLIERS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS
REMARK 500
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH
REMARK 500 CIS AND TRANS CONFORMATION. CIS BONDS, IF ANY, ARE LISTED
REMARK 500 ON CISPEP RECORDS. TRANS IS DEFINED AS 180 +/- 30 AND
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.
REMARK 500 MODEL OMEGA
REMARK 500 ALA A 599 SER A 600 -146.61
REMARK 500 TRP A 729 SER A 730 -124.38
REMARK 500 SER B 362 PRO B 363 -147.49
REMARK 500 SER C 392 TYR C 393 149.94
REMARK 500 TRP D 729 SER D 730 -123.85
REMARK 500
REMARK 500 REMARK: NULL
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: EMD-22367 RELATED DB: EMDB
REMARK 900 RELATED ID: EMD-22974 RELATED DB: EMDB
DBREF 7JKQ A 1 863 UNP Q86TI2 DPP9_HUMAN 1 863
DBREF 7JKQ B 1 537 UNP Q9Y2G2 CARD8_HUMAN 1 537
DBREF 7JKQ C 1 537 UNP Q9Y2G2 CARD8_HUMAN 1 537
DBREF 7JKQ D 1 863 UNP Q86TI2 DPP9_HUMAN 1 863
SEQRES 1 A 863 MET ALA THR THR GLY THR PRO THR ALA ASP ARG GLY ASP
SEQRES 2 A 863 ALA ALA ALA THR ASP ASP PRO ALA ALA ARG PHE GLN VAL
SEQRES 3 A 863 GLN LYS HIS SER TRP ASP GLY LEU ARG SER ILE ILE HIS
SEQRES 4 A 863 GLY SER ARG LYS TYR SER GLY LEU ILE VAL ASN LYS ALA
SEQRES 5 A 863 PRO HIS ASP PHE GLN PHE VAL GLN LYS THR ASP GLU SER
SEQRES 6 A 863 GLY PRO HIS SER HIS ARG LEU TYR TYR LEU GLY MET PRO
SEQRES 7 A 863 TYR GLY SER ARG GLU ASN SER LEU LEU TYR SER GLU ILE
SEQRES 8 A 863 PRO LYS LYS VAL ARG LYS GLU ALA LEU LEU LEU LEU SER
SEQRES 9 A 863 TRP LYS GLN MET LEU ASP HIS PHE GLN ALA THR PRO HIS
SEQRES 10 A 863 HIS GLY VAL TYR SER ARG GLU GLU GLU LEU LEU ARG GLU
SEQRES 11 A 863 ARG LYS ARG LEU GLY VAL PHE GLY ILE THR SER TYR ASP
SEQRES 12 A 863 PHE HIS SER GLU SER GLY LEU PHE LEU PHE GLN ALA SER
SEQRES 13 A 863 ASN SER LEU PHE HIS CYS ARG ASP GLY GLY LYS ASN GLY
SEQRES 14 A 863 PHE MET VAL SER PRO MET LYS PRO LEU GLU ILE LYS THR
SEQRES 15 A 863 GLN CYS SER GLY PRO ARG MET ASP PRO LYS ILE CYS PRO
SEQRES 16 A 863 ALA ASP PRO ALA PHE PHE SER PHE ILE ASN ASN SER ASP
SEQRES 17 A 863 LEU TRP VAL ALA ASN ILE GLU THR GLY GLU GLU ARG ARG
SEQRES 18 A 863 LEU THR PHE CYS HIS GLN GLY LEU SER ASN VAL LEU ASP
SEQRES 19 A 863 ASP PRO LYS SER ALA GLY VAL ALA THR PHE VAL ILE GLN
SEQRES 20 A 863 GLU GLU PHE ASP ARG PHE THR GLY TYR TRP TRP CYS PRO
SEQRES 21 A 863 THR ALA SER TRP GLU GLY SER GLU GLY LEU LYS THR LEU
SEQRES 22 A 863 ARG ILE LEU TYR GLU GLU VAL ASP GLU SER GLU VAL GLU
SEQRES 23 A 863 VAL ILE HIS VAL PRO SER PRO ALA LEU GLU GLU ARG LYS
SEQRES 24 A 863 THR ASP SER TYR ARG TYR PRO ARG THR GLY SER LYS ASN
SEQRES 25 A 863 PRO LYS ILE ALA LEU LYS LEU ALA GLU PHE GLN THR ASP
SEQRES 26 A 863 SER GLN GLY LYS ILE VAL SER THR GLN GLU LYS GLU LEU
SEQRES 27 A 863 VAL GLN PRO PHE SER SER LEU PHE PRO LYS VAL GLU TYR
SEQRES 28 A 863 ILE ALA ARG ALA GLY TRP THR ARG ASP GLY LYS TYR ALA
SEQRES 29 A 863 TRP ALA MET PHE LEU ASP ARG PRO GLN GLN TRP LEU GLN
SEQRES 30 A 863 LEU VAL LEU LEU PRO PRO ALA LEU PHE ILE PRO SER THR
SEQRES 31 A 863 GLU ASN GLU GLU GLN ARG LEU ALA SER ALA ARG ALA VAL
SEQRES 32 A 863 PRO ARG ASN VAL GLN PRO TYR VAL VAL TYR GLU GLU VAL
SEQRES 33 A 863 THR ASN VAL TRP ILE ASN VAL HIS ASP ILE PHE TYR PRO
SEQRES 34 A 863 PHE PRO GLN SER GLU GLY GLU ASP GLU LEU CYS PHE LEU
SEQRES 35 A 863 ARG ALA ASN GLU CYS LYS THR GLY PHE CYS HIS LEU TYR
SEQRES 36 A 863 LYS VAL THR ALA VAL LEU LYS SER GLN GLY TYR ASP TRP
SEQRES 37 A 863 SER GLU PRO PHE SER PRO GLY GLU ASP GLU PHE LYS CYS
SEQRES 38 A 863 PRO ILE LYS GLU GLU ILE ALA LEU THR SER GLY GLU TRP
SEQRES 39 A 863 GLU VAL LEU ALA ARG HIS GLY SER LYS ILE TRP VAL ASN
SEQRES 40 A 863 GLU GLU THR LYS LEU VAL TYR PHE GLN GLY THR LYS ASP
SEQRES 41 A 863 THR PRO LEU GLU HIS HIS LEU TYR VAL VAL SER TYR GLU
SEQRES 42 A 863 ALA ALA GLY GLU ILE VAL ARG LEU THR THR PRO GLY PHE
SEQRES 43 A 863 SER HIS SER CYS SER MET SER GLN ASN PHE ASP MET PHE
SEQRES 44 A 863 VAL SER HIS TYR SER SER VAL SER THR PRO PRO CYS VAL
SEQRES 45 A 863 HIS VAL TYR LYS LEU SER GLY PRO ASP ASP ASP PRO LEU
SEQRES 46 A 863 HIS LYS GLN PRO ARG PHE TRP ALA SER MET MET GLU ALA
SEQRES 47 A 863 ALA SER CYS PRO PRO ASP TYR VAL PRO PRO GLU ILE PHE
SEQRES 48 A 863 HIS PHE HIS THR ARG SER ASP VAL ARG LEU TYR GLY MET
SEQRES 49 A 863 ILE TYR LYS PRO HIS ALA LEU GLN PRO GLY LYS LYS HIS
SEQRES 50 A 863 PRO THR VAL LEU PHE VAL TYR GLY GLY PRO GLN VAL GLN
SEQRES 51 A 863 LEU VAL ASN ASN SER PHE LYS GLY ILE LYS TYR LEU ARG
SEQRES 52 A 863 LEU ASN THR LEU ALA SER LEU GLY TYR ALA VAL VAL VAL
SEQRES 53 A 863 ILE ASP GLY ARG GLY SER CYS GLN ARG GLY LEU ARG PHE
SEQRES 54 A 863 GLU GLY ALA LEU LYS ASN GLN MET GLY GLN VAL GLU ILE
SEQRES 55 A 863 GLU ASP GLN VAL GLU GLY LEU GLN PHE VAL ALA GLU LYS
SEQRES 56 A 863 TYR GLY PHE ILE ASP LEU SER ARG VAL ALA ILE HIS GLY
SEQRES 57 A 863 TRP SER TYR GLY GLY PHE LEU SER LEU MET GLY LEU ILE
SEQRES 58 A 863 HIS LYS PRO GLN VAL PHE LYS VAL ALA ILE ALA GLY ALA
SEQRES 59 A 863 PRO VAL THR VAL TRP MET ALA TYR ASP THR GLY TYR THR
SEQRES 60 A 863 GLU ARG TYR MET ASP VAL PRO GLU ASN ASN GLN HIS GLY
SEQRES 61 A 863 TYR GLU ALA GLY SER VAL ALA LEU HIS VAL GLU LYS LEU
SEQRES 62 A 863 PRO ASN GLU PRO ASN ARG LEU LEU ILE LEU HIS GLY PHE
SEQRES 63 A 863 LEU ASP GLU ASN VAL HIS PHE PHE HIS THR ASN PHE LEU
SEQRES 64 A 863 VAL SER GLN LEU ILE ARG ALA GLY LYS PRO TYR GLN LEU
SEQRES 65 A 863 GLN ILE TYR PRO ASN GLU ARG HIS SER ILE ARG CYS PRO
SEQRES 66 A 863 GLU SER GLY GLU HIS TYR GLU VAL THR LEU LEU HIS PHE
SEQRES 67 A 863 LEU GLN GLU TYR LEU
SEQRES 1 B 537 MET GLU LYS LYS GLU CYS PRO GLU LYS SER SER SER SER
SEQRES 2 B 537 GLU GLU GLU LEU PRO ARG ARG ASP SER GLY SER SER ARG
SEQRES 3 B 537 ASN ILE ASP ALA SER LYS LEU ILE ARG LEU GLN GLY SER
SEQRES 4 B 537 ARG LYS LEU LEU VAL ASP ASN SER ILE ARG GLU LEU GLN
SEQRES 5 B 537 TYR THR LYS THR GLY ILE PHE PHE GLN ALA GLU ALA CYS
SEQRES 6 B 537 VAL THR ASN ASP THR VAL TYR ARG GLU LEU PRO CYS VAL
SEQRES 7 B 537 SER GLU THR LEU CYS ASP ILE SER HIS PHE PHE GLN GLU
SEQRES 8 B 537 ASP ASP GLU THR GLU ALA GLU PRO LEU LEU PHE ARG ALA
SEQRES 9 B 537 VAL PRO GLU CYS GLN LEU SER GLY GLY ASP ILE PRO SER
SEQRES 10 B 537 VAL SER GLU GLU GLN GLU SER SER GLU GLY GLN ASP SER
SEQRES 11 B 537 GLY ASP ILE CYS SER GLU GLU ASN GLN ILE VAL SER SER
SEQRES 12 B 537 TYR ALA SER LYS VAL CYS PHE GLU ILE GLU GLU ASP TYR
SEQRES 13 B 537 LYS ASN ARG GLN PHE LEU GLY PRO GLU GLY ASN VAL ASP
SEQRES 14 B 537 VAL GLU LEU ILE ASP LYS SER THR ASN ARG TYR SER VAL
SEQRES 15 B 537 TRP PHE PRO THR ALA GLY TRP TYR LEU TRP SER ALA THR
SEQRES 16 B 537 GLY LEU GLY PHE LEU VAL ARG ASP GLU VAL THR VAL THR
SEQRES 17 B 537 ILE ALA PHE GLY SER TRP SER GLN HIS LEU ALA LEU ASP
SEQRES 18 B 537 LEU GLN HIS HIS GLU GLN TRP LEU VAL GLY GLY PRO LEU
SEQRES 19 B 537 PHE ASP VAL THR ALA GLU PRO GLU GLU ALA VAL ALA GLU
SEQRES 20 B 537 ILE HIS LEU PRO HIS PHE ILE SER LEU GLN ALA GLY GLU
SEQRES 21 B 537 VAL ASP VAL SER TRP PHE LEU VAL ALA HIS PHE LYS ASN
SEQRES 22 B 537 GLU GLY MET VAL LEU GLU HIS PRO ALA ARG VAL GLU PRO
SEQRES 23 B 537 PHE TYR ALA VAL LEU GLU SER PRO SER PHE SER LEU MET
SEQRES 24 B 537 GLY ILE LEU LEU ARG ILE ALA SER GLY THR ARG LEU SER
SEQRES 25 B 537 ILE PRO ILE THR SER ASN THR LEU ILE TYR TYR HIS PRO
SEQRES 26 B 537 HIS PRO GLU ASP ILE LYS PHE HIS LEU TYR LEU VAL PRO
SEQRES 27 B 537 SER ASP ALA LEU LEU THR LYS ALA ILE ASP ASP GLU GLU
SEQRES 28 B 537 ASP ARG PHE HIS GLY VAL ARG LEU GLN THR SER PRO PRO
SEQRES 29 B 537 MET GLU PRO LEU ASN PHE GLY SER SER TYR ILE VAL SER
SEQRES 30 B 537 ASN SER ALA ASN LEU LYS VAL MET PRO LYS GLU LEU LYS
SEQRES 31 B 537 LEU SER TYR ARG SER PRO GLY GLU ILE GLN HIS PHE SER
SEQRES 32 B 537 LYS PHE TYR ALA GLY GLN MET LYS GLU PRO ILE GLN LEU
SEQRES 33 B 537 GLU ILE THR GLU LYS ARG HIS GLY THR LEU VAL TRP ASP
SEQRES 34 B 537 THR GLU VAL LYS PRO VAL ASP LEU GLN LEU VAL ALA ALA
SEQRES 35 B 537 SER ALA PRO PRO PRO PHE SER GLY ALA ALA PHE VAL LYS
SEQRES 36 B 537 GLU ASN HIS ARG GLN LEU GLN ALA ARG MET GLY ASP LEU
SEQRES 37 B 537 LYS GLY VAL LEU ASP ASP LEU GLN ASP ASN GLU VAL LEU
SEQRES 38 B 537 THR GLU ASN GLU LYS GLU LEU VAL GLU GLN GLU LYS THR
SEQRES 39 B 537 ARG GLN SER LYS ASN GLU ALA LEU LEU SER MET VAL GLU
SEQRES 40 B 537 LYS LYS GLY ASP LEU ALA LEU ASP VAL LEU PHE ARG SER
SEQRES 41 B 537 ILE SER GLU ARG ASP PRO TYR LEU VAL SER TYR LEU ARG
SEQRES 42 B 537 GLN GLN ASN LEU
SEQRES 1 C 537 MET GLU LYS LYS GLU CYS PRO GLU LYS SER SER SER SER
SEQRES 2 C 537 GLU GLU GLU LEU PRO ARG ARG ASP SER GLY SER SER ARG
SEQRES 3 C 537 ASN ILE ASP ALA SER LYS LEU ILE ARG LEU GLN GLY SER
SEQRES 4 C 537 ARG LYS LEU LEU VAL ASP ASN SER ILE ARG GLU LEU GLN
SEQRES 5 C 537 TYR THR LYS THR GLY ILE PHE PHE GLN ALA GLU ALA CYS
SEQRES 6 C 537 VAL THR ASN ASP THR VAL TYR ARG GLU LEU PRO CYS VAL
SEQRES 7 C 537 SER GLU THR LEU CYS ASP ILE SER HIS PHE PHE GLN GLU
SEQRES 8 C 537 ASP ASP GLU THR GLU ALA GLU PRO LEU LEU PHE ARG ALA
SEQRES 9 C 537 VAL PRO GLU CYS GLN LEU SER GLY GLY ASP ILE PRO SER
SEQRES 10 C 537 VAL SER GLU GLU GLN GLU SER SER GLU GLY GLN ASP SER
SEQRES 11 C 537 GLY ASP ILE CYS SER GLU GLU ASN GLN ILE VAL SER SER
SEQRES 12 C 537 TYR ALA SER LYS VAL CYS PHE GLU ILE GLU GLU ASP TYR
SEQRES 13 C 537 LYS ASN ARG GLN PHE LEU GLY PRO GLU GLY ASN VAL ASP
SEQRES 14 C 537 VAL GLU LEU ILE ASP LYS SER THR ASN ARG TYR SER VAL
SEQRES 15 C 537 TRP PHE PRO THR ALA GLY TRP TYR LEU TRP SER ALA THR
SEQRES 16 C 537 GLY LEU GLY PHE LEU VAL ARG ASP GLU VAL THR VAL THR
SEQRES 17 C 537 ILE ALA PHE GLY SER TRP SER GLN HIS LEU ALA LEU ASP
SEQRES 18 C 537 LEU GLN HIS HIS GLU GLN TRP LEU VAL GLY GLY PRO LEU
SEQRES 19 C 537 PHE ASP VAL THR ALA GLU PRO GLU GLU ALA VAL ALA GLU
SEQRES 20 C 537 ILE HIS LEU PRO HIS PHE ILE SER LEU GLN ALA GLY GLU
SEQRES 21 C 537 VAL ASP VAL SER TRP PHE LEU VAL ALA HIS PHE LYS ASN
SEQRES 22 C 537 GLU GLY MET VAL LEU GLU HIS PRO ALA ARG VAL GLU PRO
SEQRES 23 C 537 PHE TYR ALA VAL LEU GLU SER PRO SER PHE SER LEU MET
SEQRES 24 C 537 GLY ILE LEU LEU ARG ILE ALA SER GLY THR ARG LEU SER
SEQRES 25 C 537 ILE PRO ILE THR SER ASN THR LEU ILE TYR TYR HIS PRO
SEQRES 26 C 537 HIS PRO GLU ASP ILE LYS PHE HIS LEU TYR LEU VAL PRO
SEQRES 27 C 537 SER ASP ALA LEU LEU THR LYS ALA ILE ASP ASP GLU GLU
SEQRES 28 C 537 ASP ARG PHE HIS GLY VAL ARG LEU GLN THR SER PRO PRO
SEQRES 29 C 537 MET GLU PRO LEU ASN PHE GLY SER SER TYR ILE VAL SER
SEQRES 30 C 537 ASN SER ALA ASN LEU LYS VAL MET PRO LYS GLU LEU LYS
SEQRES 31 C 537 LEU SER TYR ARG SER PRO GLY GLU ILE GLN HIS PHE SER
SEQRES 32 C 537 LYS PHE TYR ALA GLY GLN MET LYS GLU PRO ILE GLN LEU
SEQRES 33 C 537 GLU ILE THR GLU LYS ARG HIS GLY THR LEU VAL TRP ASP
SEQRES 34 C 537 THR GLU VAL LYS PRO VAL ASP LEU GLN LEU VAL ALA ALA
SEQRES 35 C 537 SER ALA PRO PRO PRO PHE SER GLY ALA ALA PHE VAL LYS
SEQRES 36 C 537 GLU ASN HIS ARG GLN LEU GLN ALA ARG MET GLY ASP LEU
SEQRES 37 C 537 LYS GLY VAL LEU ASP ASP LEU GLN ASP ASN GLU VAL LEU
SEQRES 38 C 537 THR GLU ASN GLU LYS GLU LEU VAL GLU GLN GLU LYS THR
SEQRES 39 C 537 ARG GLN SER LYS ASN GLU ALA LEU LEU SER MET VAL GLU
SEQRES 40 C 537 LYS LYS GLY ASP LEU ALA LEU ASP VAL LEU PHE ARG SER
SEQRES 41 C 537 ILE SER GLU ARG ASP PRO TYR LEU VAL SER TYR LEU ARG
SEQRES 42 C 537 GLN GLN ASN LEU
SEQRES 1 D 863 MET ALA THR THR GLY THR PRO THR ALA ASP ARG GLY ASP
SEQRES 2 D 863 ALA ALA ALA THR ASP ASP PRO ALA ALA ARG PHE GLN VAL
SEQRES 3 D 863 GLN LYS HIS SER TRP ASP GLY LEU ARG SER ILE ILE HIS
SEQRES 4 D 863 GLY SER ARG LYS TYR SER GLY LEU ILE VAL ASN LYS ALA
SEQRES 5 D 863 PRO HIS ASP PHE GLN PHE VAL GLN LYS THR ASP GLU SER
SEQRES 6 D 863 GLY PRO HIS SER HIS ARG LEU TYR TYR LEU GLY MET PRO
SEQRES 7 D 863 TYR GLY SER ARG GLU ASN SER LEU LEU TYR SER GLU ILE
SEQRES 8 D 863 PRO LYS LYS VAL ARG LYS GLU ALA LEU LEU LEU LEU SER
SEQRES 9 D 863 TRP LYS GLN MET LEU ASP HIS PHE GLN ALA THR PRO HIS
SEQRES 10 D 863 HIS GLY VAL TYR SER ARG GLU GLU GLU LEU LEU ARG GLU
SEQRES 11 D 863 ARG LYS ARG LEU GLY VAL PHE GLY ILE THR SER TYR ASP
SEQRES 12 D 863 PHE HIS SER GLU SER GLY LEU PHE LEU PHE GLN ALA SER
SEQRES 13 D 863 ASN SER LEU PHE HIS CYS ARG ASP GLY GLY LYS ASN GLY
SEQRES 14 D 863 PHE MET VAL SER PRO MET LYS PRO LEU GLU ILE LYS THR
SEQRES 15 D 863 GLN CYS SER GLY PRO ARG MET ASP PRO LYS ILE CYS PRO
SEQRES 16 D 863 ALA ASP PRO ALA PHE PHE SER PHE ILE ASN ASN SER ASP
SEQRES 17 D 863 LEU TRP VAL ALA ASN ILE GLU THR GLY GLU GLU ARG ARG
SEQRES 18 D 863 LEU THR PHE CYS HIS GLN GLY LEU SER ASN VAL LEU ASP
SEQRES 19 D 863 ASP PRO LYS SER ALA GLY VAL ALA THR PHE VAL ILE GLN
SEQRES 20 D 863 GLU GLU PHE ASP ARG PHE THR GLY TYR TRP TRP CYS PRO
SEQRES 21 D 863 THR ALA SER TRP GLU GLY SER GLU GLY LEU LYS THR LEU
SEQRES 22 D 863 ARG ILE LEU TYR GLU GLU VAL ASP GLU SER GLU VAL GLU
SEQRES 23 D 863 VAL ILE HIS VAL PRO SER PRO ALA LEU GLU GLU ARG LYS
SEQRES 24 D 863 THR ASP SER TYR ARG TYR PRO ARG THR GLY SER LYS ASN
SEQRES 25 D 863 PRO LYS ILE ALA LEU LYS LEU ALA GLU PHE GLN THR ASP
SEQRES 26 D 863 SER GLN GLY LYS ILE VAL SER THR GLN GLU LYS GLU LEU
SEQRES 27 D 863 VAL GLN PRO PHE SER SER LEU PHE PRO LYS VAL GLU TYR
SEQRES 28 D 863 ILE ALA ARG ALA GLY TRP THR ARG ASP GLY LYS TYR ALA
SEQRES 29 D 863 TRP ALA MET PHE LEU ASP ARG PRO GLN GLN TRP LEU GLN
SEQRES 30 D 863 LEU VAL LEU LEU PRO PRO ALA LEU PHE ILE PRO SER THR
SEQRES 31 D 863 GLU ASN GLU GLU GLN ARG LEU ALA SER ALA ARG ALA VAL
SEQRES 32 D 863 PRO ARG ASN VAL GLN PRO TYR VAL VAL TYR GLU GLU VAL
SEQRES 33 D 863 THR ASN VAL TRP ILE ASN VAL HIS ASP ILE PHE TYR PRO
SEQRES 34 D 863 PHE PRO GLN SER GLU GLY GLU ASP GLU LEU CYS PHE LEU
SEQRES 35 D 863 ARG ALA ASN GLU CYS LYS THR GLY PHE CYS HIS LEU TYR
SEQRES 36 D 863 LYS VAL THR ALA VAL LEU LYS SER GLN GLY TYR ASP TRP
SEQRES 37 D 863 SER GLU PRO PHE SER PRO GLY GLU ASP GLU PHE LYS CYS
SEQRES 38 D 863 PRO ILE LYS GLU GLU ILE ALA LEU THR SER GLY GLU TRP
SEQRES 39 D 863 GLU VAL LEU ALA ARG HIS GLY SER LYS ILE TRP VAL ASN
SEQRES 40 D 863 GLU GLU THR LYS LEU VAL TYR PHE GLN GLY THR LYS ASP
SEQRES 41 D 863 THR PRO LEU GLU HIS HIS LEU TYR VAL VAL SER TYR GLU
SEQRES 42 D 863 ALA ALA GLY GLU ILE VAL ARG LEU THR THR PRO GLY PHE
SEQRES 43 D 863 SER HIS SER CYS SER MET SER GLN ASN PHE ASP MET PHE
SEQRES 44 D 863 VAL SER HIS TYR SER SER VAL SER THR PRO PRO CYS VAL
SEQRES 45 D 863 HIS VAL TYR LYS LEU SER GLY PRO ASP ASP ASP PRO LEU
SEQRES 46 D 863 HIS LYS GLN PRO ARG PHE TRP ALA SER MET MET GLU ALA
SEQRES 47 D 863 ALA SER CYS PRO PRO ASP TYR VAL PRO PRO GLU ILE PHE
SEQRES 48 D 863 HIS PHE HIS THR ARG SER ASP VAL ARG LEU TYR GLY MET
SEQRES 49 D 863 ILE TYR LYS PRO HIS ALA LEU GLN PRO GLY LYS LYS HIS
SEQRES 50 D 863 PRO THR VAL LEU PHE VAL TYR GLY GLY PRO GLN VAL GLN
SEQRES 51 D 863 LEU VAL ASN ASN SER PHE LYS GLY ILE LYS TYR LEU ARG
SEQRES 52 D 863 LEU ASN THR LEU ALA SER LEU GLY TYR ALA VAL VAL VAL
SEQRES 53 D 863 ILE ASP GLY ARG GLY SER CYS GLN ARG GLY LEU ARG PHE
SEQRES 54 D 863 GLU GLY ALA LEU LYS ASN GLN MET GLY GLN VAL GLU ILE
SEQRES 55 D 863 GLU ASP GLN VAL GLU GLY LEU GLN PHE VAL ALA GLU LYS
SEQRES 56 D 863 TYR GLY PHE ILE ASP LEU SER ARG VAL ALA ILE HIS GLY
SEQRES 57 D 863 TRP SER TYR GLY GLY PHE LEU SER LEU MET GLY LEU ILE
SEQRES 58 D 863 HIS LYS PRO GLN VAL PHE LYS VAL ALA ILE ALA GLY ALA
SEQRES 59 D 863 PRO VAL THR VAL TRP MET ALA TYR ASP THR GLY TYR THR
SEQRES 60 D 863 GLU ARG TYR MET ASP VAL PRO GLU ASN ASN GLN HIS GLY
SEQRES 61 D 863 TYR GLU ALA GLY SER VAL ALA LEU HIS VAL GLU LYS LEU
SEQRES 62 D 863 PRO ASN GLU PRO ASN ARG LEU LEU ILE LEU HIS GLY PHE
SEQRES 63 D 863 LEU ASP GLU ASN VAL HIS PHE PHE HIS THR ASN PHE LEU
SEQRES 64 D 863 VAL SER GLN LEU ILE ARG ALA GLY LYS PRO TYR GLN LEU
SEQRES 65 D 863 GLN ILE TYR PRO ASN GLU ARG HIS SER ILE ARG CYS PRO
SEQRES 66 D 863 GLU SER GLY GLU HIS TYR GLU VAL THR LEU LEU HIS PHE
SEQRES 67 D 863 LEU GLN GLU TYR LEU
HELIX 1 AA1 ASP A 19 ARG A 23 5 5
HELIX 2 AA2 SER A 30 ARG A 42 1 13
HELIX 3 AA3 TYR A 44 VAL A 49 1 6
HELIX 4 AA4 THR A 243 PHE A 250 1 8
HELIX 5 AA5 PRO A 341 PHE A 346 1 6
HELIX 6 AA6 PRO A 382 ALA A 384 5 3
HELIX 7 AA7 ASN A 392 VAL A 403 1 12
HELIX 8 AA8 GLU A 446 GLY A 450 1 5
HELIX 9 AA9 ASP A 583 LYS A 587 5 5
HELIX 10 AB1 TYR A 661 GLY A 671 1 11
HELIX 11 AB2 GLY A 686 GLY A 691 1 6
HELIX 12 AB3 ALA A 692 LYS A 694 5 3
HELIX 13 AB4 VAL A 700 TYR A 716 1 17
HELIX 14 AB5 SER A 730 LYS A 743 1 14
HELIX 15 AB6 ASP A 763 MET A 771 1 9
HELIX 16 AB7 ASN A 777 SER A 785 1 9
HELIX 17 AB8 VAL A 786 LEU A 793 5 8
HELIX 18 AB9 HIS A 812 GLY A 827 1 16
HELIX 19 AC1 CYS A 844 LEU A 863 1 20
HELIX 20 AC2 SER B 213 LEU B 218 1 6
HELIX 21 AC3 ASP B 262 SER B 264 5 3
HELIX 22 AC4 SER B 317 ILE B 321 5 5
HELIX 23 AC5 ASP B 348 GLN B 360 1 13
HELIX 24 AC6 GLU C 350 LEU C 359 1 10
HELIX 25 AC7 GLN C 360 SER C 362 5 3
HELIX 26 AC8 ASP D 19 ARG D 23 5 5
HELIX 27 AC9 SER D 30 ARG D 42 1 13
HELIX 28 AD1 TYR D 44 VAL D 49 1 6
HELIX 29 AD2 THR D 243 PHE D 250 1 8
HELIX 30 AD3 PRO D 341 PHE D 346 1 6
HELIX 31 AD4 PRO D 382 ALA D 384 5 3
HELIX 32 AD5 ASN D 392 VAL D 403 1 12
HELIX 33 AD6 ASP D 583 LYS D 587 5 5
HELIX 34 AD7 TYR D 661 GLY D 671 1 11
HELIX 35 AD8 GLY D 686 GLY D 691 1 6
HELIX 36 AD9 ALA D 692 LYS D 694 5 3
HELIX 37 AE1 VAL D 700 TYR D 716 1 17
HELIX 38 AE2 SER D 730 LYS D 743 1 14
HELIX 39 AE3 ASP D 763 MET D 771 1 9
HELIX 40 AE4 ASN D 777 SER D 785 1 9
HELIX 41 AE5 VAL D 786 LEU D 793 5 8
HELIX 42 AE6 HIS D 812 GLY D 827 1 16
HELIX 43 AE7 CYS D 844 LEU D 863 1 20
SHEET 1 AA1 4 HIS A 54 GLN A 60 0
SHEET 2 AA1 4 HIS A 68 GLY A 76 -1 O TYR A 73 N GLN A 57
SHEET 3 AA1 4 SER A 85 PRO A 92 -1 O LEU A 87 N TYR A 74
SHEET 4 AA1 4 LYS A 106 GLN A 107 -1 O LYS A 106 N TYR A 88
SHEET 1 AA2 4 LEU A 100 LEU A 103 0
SHEET 2 AA2 4 GLY B 275 GLU B 279 -1 O MET B 276 N LEU A 102
SHEET 3 AA2 4 PHE B 266 PHE B 271 -1 N VAL B 268 O GLU B 279
SHEET 4 AA2 4 LEU B 311 SER B 312 -1 O LEU B 311 N LEU B 267
SHEET 1 AA3 4 TYR A 142 HIS A 145 0
SHEET 2 AA3 4 LEU A 150 ALA A 155 -1 O LEU A 152 N ASP A 143
SHEET 3 AA3 4 SER A 158 ARG A 163 -1 O CYS A 162 N PHE A 151
SHEET 4 AA3 4 LEU A 178 ILE A 180 -1 O ILE A 180 N LEU A 159
SHEET 1 AA4 4 ARG A 188 ILE A 193 0
SHEET 2 AA4 4 PHE A 200 ASN A 205 -1 O ILE A 204 N MET A 189
SHEET 3 AA4 4 ASP A 208 ASN A 213 -1 O TRP A 210 N PHE A 203
SHEET 4 AA4 4 GLU A 219 ARG A 221 -1 O ARG A 220 N VAL A 211
SHEET 1 AA5 3 LYS A 237 ALA A 239 0
SHEET 2 AA5 3 LYS A 271 ASP A 281 -1 O VAL A 280 N SER A 238
SHEET 3 AA5 3 TYR A 256 TRP A 258 -1 N TRP A 257 O LEU A 276
SHEET 1 AA6 5 LYS A 237 ALA A 239 0
SHEET 2 AA6 5 LYS A 271 ASP A 281 -1 O VAL A 280 N SER A 238
SHEET 3 AA6 5 LYS A 314 THR A 324 -1 O ALA A 320 N ILE A 275
SHEET 4 AA6 5 ILE A 330 LEU A 338 -1 O GLN A 334 N GLU A 321
SHEET 5 AA6 5 PHE A 386 PRO A 388 -1 O ILE A 387 N GLU A 337
SHEET 1 AA7 2 VAL A 287 PRO A 291 0
SHEET 2 AA7 2 THR A 300 ARG A 304 -1 O ASP A 301 N VAL A 290
SHEET 1 AA8 4 TYR A 351 TRP A 357 0
SHEET 2 AA8 4 ALA A 364 LEU A 369 -1 O LEU A 369 N TYR A 351
SHEET 3 AA8 4 TRP A 375 LEU A 381 -1 O GLN A 377 N PHE A 368
SHEET 4 AA8 4 TYR A 410 VAL A 416 -1 O TYR A 413 N LEU A 378
SHEET 1 AA9 3 LEU A 439 ASN A 445 0
SHEET 2 AA9 3 HIS A 453 ALA A 459 -1 O VAL A 457 N PHE A 441
SHEET 3 AA9 3 ILE A 483 ALA A 488 -1 O GLU A 485 N THR A 458
SHEET 1 AB1 3 VAL A 496 LEU A 497 0
SHEET 2 AB1 3 LEU A 512 GLY A 517 -1 O GLN A 516 N LEU A 497
SHEET 3 AB1 3 TRP A 505 ASN A 507 -1 N TRP A 505 O TYR A 514
SHEET 1 AB2 4 VAL A 496 LEU A 497 0
SHEET 2 AB2 4 LEU A 512 GLY A 517 -1 O GLN A 516 N LEU A 497
SHEET 3 AB2 4 HIS A 526 SER A 531 -1 O TYR A 528 N PHE A 515
SHEET 4 AB2 4 VAL A 539 ARG A 540 -1 O VAL A 539 N VAL A 529
SHEET 1 AB3 4 SER A 547 MET A 552 0
SHEET 2 AB3 4 MET A 558 SER A 564 -1 O HIS A 562 N SER A 549
SHEET 3 AB3 4 CYS A 571 SER A 578 -1 O CYS A 571 N TYR A 563
SHEET 4 AB3 4 GLN A 588 MET A 596 -1 O ALA A 593 N VAL A 574
SHEET 1 AB4 8 GLU A 609 HIS A 614 0
SHEET 2 AB4 8 ARG A 620 TYR A 626 -1 O GLY A 623 N PHE A 611
SHEET 3 AB4 8 ALA A 673 ASP A 678 -1 O VAL A 676 N MET A 624
SHEET 4 AB4 8 HIS A 637 VAL A 643 1 N VAL A 640 O ALA A 673
SHEET 5 AB4 8 ILE A 719 TRP A 729 1 O ALA A 725 N LEU A 641
SHEET 6 AB4 8 VAL A 749 GLY A 753 1 O GLY A 753 N GLY A 728
SHEET 7 AB4 8 LEU A 800 GLY A 805 1 O LEU A 803 N ALA A 752
SHEET 8 AB4 8 GLN A 831 TYR A 835 1 O GLN A 831 N ILE A 802
SHEET 1 AB5 4 GLU B 171 ASP B 174 0
SHEET 2 AB5 4 ARG B 179 PHE B 184 -1 O ARG B 179 N ILE B 173
SHEET 3 AB5 4 VAL B 205 GLY B 212 -1 O VAL B 207 N VAL B 182
SHEET 4 AB5 4 LEU B 234 THR B 238 -1 O THR B 238 N THR B 208
SHEET 1 AB6 4 LEU B 191 TRP B 192 0
SHEET 2 AB6 4 LEU B 197 VAL B 201 -1 O LEU B 197 N TRP B 192
SHEET 3 AB6 4 VAL B 245 PRO B 251 -1 O HIS B 249 N GLY B 198
SHEET 4 AB6 4 TYR B 288 GLU B 292 -1 O ALA B 289 N LEU B 250
SHEET 1 AB7 2 HIS B 326 LEU B 334 0
SHEET 2 AB7 2 VAL B 337 LYS B 345 -1 O LYS B 345 N HIS B 326
SHEET 1 AB8 4 PRO B 396 GLU B 398 0
SHEET 2 AB8 4 ASN B 381 PRO B 386 -1 N LEU B 382 O GLY B 397
SHEET 3 AB8 4 LYS B 421 VAL B 427 -1 O VAL B 427 N LYS B 383
SHEET 4 AB8 4 PRO B 434 ALA B 441 -1 O VAL B 440 N ARG B 422
SHEET 1 AB9 2 HIS C 326 PHE C 332 0
SHEET 2 AB9 2 SER C 339 LYS C 345 -1 O LEU C 343 N GLU C 328
SHEET 1 AC1 4 PRO C 396 ILE C 399 0
SHEET 2 AC1 4 ALA C 380 PRO C 386 -1 N LEU C 382 O GLY C 397
SHEET 3 AC1 4 LYS C 421 VAL C 427 -1 O VAL C 427 N LYS C 383
SHEET 4 AC1 4 PRO C 434 ALA C 441 -1 O VAL C 435 N LEU C 426
SHEET 1 AC2 4 GLN D 57 GLN D 60 0
SHEET 2 AC2 4 HIS D 68 GLY D 76 -1 O TYR D 73 N GLN D 57
SHEET 3 AC2 4 SER D 85 PRO D 92 -1 O SER D 85 N GLY D 76
SHEET 4 AC2 4 LYS D 106 GLN D 107 -1 O LYS D 106 N TYR D 88
SHEET 1 AC3 4 THR D 140 HIS D 145 0
SHEET 2 AC3 4 LEU D 150 ALA D 155 -1 O LEU D 152 N ASP D 143
SHEET 3 AC3 4 SER D 158 ARG D 163 -1 O CYS D 162 N PHE D 151
SHEET 4 AC3 4 LEU D 178 GLU D 179 -1 O LEU D 178 N HIS D 161
SHEET 1 AC4 4 ARG D 188 ILE D 193 0
SHEET 2 AC4 4 PHE D 200 ASN D 205 -1 O ILE D 204 N MET D 189
SHEET 3 AC4 4 ASP D 208 ASN D 213 -1 O TRP D 210 N PHE D 203
SHEET 4 AC4 4 GLU D 219 ARG D 221 -1 O ARG D 220 N VAL D 211
SHEET 1 AC5 3 LYS D 237 ALA D 239 0
SHEET 2 AC5 3 LYS D 271 ASP D 281 -1 O VAL D 280 N SER D 238
SHEET 3 AC5 3 TYR D 256 TRP D 258 -1 N TRP D 257 O LEU D 276
SHEET 1 AC6 5 LYS D 237 ALA D 239 0
SHEET 2 AC6 5 LYS D 271 ASP D 281 -1 O VAL D 280 N SER D 238
SHEET 3 AC6 5 LYS D 314 THR D 324 -1 O ALA D 320 N ILE D 275
SHEET 4 AC6 5 ILE D 330 LEU D 338 -1 O GLN D 334 N GLU D 321
SHEET 5 AC6 5 PHE D 386 PRO D 388 -1 O ILE D 387 N GLU D 337
SHEET 1 AC7 2 VAL D 287 PRO D 291 0
SHEET 2 AC7 2 THR D 300 ARG D 304 -1 O ASP D 301 N VAL D 290
SHEET 1 AC8 4 TYR D 351 ALA D 355 0
SHEET 2 AC8 4 ALA D 364 LEU D 369 -1 O MET D 367 N ARG D 354
SHEET 3 AC8 4 TRP D 375 LEU D 381 -1 O GLN D 377 N PHE D 368
SHEET 4 AC8 4 TYR D 410 VAL D 416 -1 O TYR D 413 N LEU D 378
SHEET 1 AC9 4 PHE D 427 PRO D 429 0
SHEET 2 AC9 4 LEU D 439 ASN D 445 -1 O LEU D 442 N TYR D 428
SHEET 3 AC9 4 HIS D 453 ALA D 459 -1 O VAL D 457 N PHE D 441
SHEET 4 AC9 4 ILE D 483 ALA D 488 -1 O LYS D 484 N THR D 458
SHEET 1 AD1 4 TRP D 505 ASN D 507 0
SHEET 2 AD1 4 LEU D 512 GLY D 517 -1 O TYR D 514 N TRP D 505
SHEET 3 AD1 4 HIS D 526 SER D 531 -1 O TYR D 528 N PHE D 515
SHEET 4 AD1 4 VAL D 539 ARG D 540 -1 O VAL D 539 N VAL D 529
SHEET 1 AD2 4 SER D 547 MET D 552 0
SHEET 2 AD2 4 MET D 558 SER D 564 -1 O HIS D 562 N SER D 549
SHEET 3 AD2 4 CYS D 571 SER D 578 -1 O CYS D 571 N TYR D 563
SHEET 4 AD2 4 GLN D 588 MET D 596 -1 O ALA D 593 N VAL D 574
SHEET 1 AD3 8 GLU D 609 HIS D 614 0
SHEET 2 AD3 8 ARG D 620 TYR D 626 -1 O ILE D 625 N GLU D 609
SHEET 3 AD3 8 ALA D 673 ASP D 678 -1 O VAL D 674 N TYR D 626
SHEET 4 AD3 8 HIS D 637 VAL D 643 1 N VAL D 640 O ALA D 673
SHEET 5 AD3 8 ILE D 719 TRP D 729 1 O ALA D 725 N LEU D 641
SHEET 6 AD3 8 VAL D 749 GLY D 753 1 O GLY D 753 N GLY D 728
SHEET 7 AD3 8 LEU D 800 GLY D 805 1 O LEU D 803 N ALA D 752
SHEET 8 AD3 8 GLN D 831 TYR D 835 1 O GLN D 831 N ILE D 802
CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1
ORIGX1 1.000000 0.000000 0.000000 0.00000
ORIGX2 0.000000 1.000000 0.000000 0.00000
ORIGX3 0.000000 0.000000 1.000000 0.00000
SCALE1 1.000000 0.000000 0.000000 0.00000
SCALE2 0.000000 1.000000 0.000000 0.00000
SCALE3 0.000000 0.000000 1.000000 0.00000
TER 6651 LEU A 863
TER 8805 PRO B 445
TER 9829 PRO C 446
TER 16441 LEU D 863
MASTER 990 0 0 43 118 0 0 616437 4 0 218
END |