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HEADER IMMUNE SYSTEM, HYDROLASE 04-AUG-20 7JN7
TITLE HUMAN DPP9-CARD8 COMPLEX
COMPND MOL_ID: 1;
COMPND 2 MOLECULE: DIPEPTIDYL PEPTIDASE 9;
COMPND 3 CHAIN: A, D;
COMPND 4 SYNONYM: DP9,DIPEPTIDYL PEPTIDASE IV-RELATED PROTEIN 2,DPRP-2,
COMPND 5 DIPEPTIDYL PEPTIDASE IX,DPP IX,DIPEPTIDYL PEPTIDASE-LIKE PROTEIN 9,
COMPND 6 DPLP9;
COMPND 7 EC: 3.4.14.5;
COMPND 8 ENGINEERED: YES;
COMPND 9 MOL_ID: 2;
COMPND 10 MOLECULE: CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 8;
COMPND 11 CHAIN: B, C;
COMPND 12 SYNONYM: APOPTOTIC PROTEIN NDPP1,CARD-INHIBITOR OF NF-KAPPA-B-
COMPND 13 ACTIVATING LIGAND,CARDINAL,DACAR,TUMOR UP-REGULATED CARD-CONTAINING
COMPND 14 ANTAGONIST OF CASP9,TUCAN,CARD8;
COMPND 15 ENGINEERED: YES
SOURCE MOL_ID: 1;
SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 3 ORGANISM_COMMON: HUMAN;
SOURCE 4 ORGANISM_TAXID: 9606;
SOURCE 5 GENE: DPP9, DPRP2;
SOURCE 6 EXPRESSION_SYSTEM: HOMO SAPIENS;
SOURCE 7 EXPRESSION_SYSTEM_COMMON: HUMAN;
SOURCE 8 EXPRESSION_SYSTEM_TAXID: 9606;
SOURCE 9 EXPRESSION_SYSTEM_CELL_LINE: HEK293;
SOURCE 10 MOL_ID: 2;
SOURCE 11 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 12 ORGANISM_COMMON: HUMAN;
SOURCE 13 ORGANISM_TAXID: 9606;
SOURCE 14 GENE: CARD8, KIAA0955, NDPP1;
SOURCE 15 EXPRESSION_SYSTEM: HOMO SAPIENS;
SOURCE 16 EXPRESSION_SYSTEM_COMMON: HUMAN;
SOURCE 17 EXPRESSION_SYSTEM_TAXID: 9606;
SOURCE 18 EXPRESSION_SYSTEM_CELL_LINE: HEK293
KEYWDS CARD8, DPP9, INFLAMMASOME, VAL-BOROPRO (VBP), TALABOSTAT, INNATE
KEYWDS 2 IMMUNITY, IMMUNE SYSTEM, HYDROLASE
EXPDTA ELECTRON MICROSCOPY
AUTHOR H.SHARIF,L.R.HOLLINGSWORTH
REVDAT 1 19-MAY-21 7JN7 0
JRNL AUTH H.SHARIF,L.R.HOLLINGSWORTH
JRNL TITL HUMAN DPP9-CARD8 COMPLEX
JRNL REF TO BE PUBLISHED
JRNL REFN
REMARK 2
REMARK 2 RESOLUTION. 3.30 ANGSTROMS.
REMARK 3
REMARK 3 REFINEMENT.
REMARK 3 SOFTWARE PACKAGES : CRYOLO, SERIALEM, CTFFIND, PHENIX,
REMARK 3 PHENIX, RELION, RELION, RELION, RELION
REMARK 3 RECONSTRUCTION SCHEMA : FOURIER SPACE
REMARK 3
REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT
REMARK 3 PDB ENTRY : 6EOQ
REMARK 3 REFINEMENT SPACE : NULL
REMARK 3 REFINEMENT PROTOCOL : OTHER
REMARK 3 REFINEMENT TARGET : NULL
REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL
REMARK 3
REMARK 3 FITTING PROCEDURE : NULL
REMARK 3
REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS
REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.300
REMARK 3 NUMBER OF PARTICLES : 205538
REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE
REMARK 3 CORRECTION
REMARK 3
REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL
REMARK 3
REMARK 3 OTHER DETAILS: NULL
REMARK 4
REMARK 4 7JN7 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 04-AUG-20.
REMARK 100 THE DEPOSITION ID IS D_1000251096.
REMARK 245
REMARK 245 EXPERIMENTAL DETAILS
REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE
REMARK 245 SPECIMEN TYPE : NULL
REMARK 245
REMARK 245 ELECTRON MICROSCOPE SAMPLE
REMARK 245 SAMPLE TYPE : PARTICLE
REMARK 245 PARTICLE TYPE : POINT
REMARK 245 NAME OF SAMPLE : DPP9-CARD8 COMPLEX
REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 0.50
REMARK 245 SAMPLE SUPPORT DETAILS : NULL
REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL
REMARK 245 SAMPLE BUFFER : NULL
REMARK 245 PH : 7.50
REMARK 245 SAMPLE DETAILS : NULL
REMARK 245
REMARK 245 DATA ACQUISITION
REMARK 245 DATE OF EXPERIMENT : NULL
REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : 2488
REMARK 245 TEMPERATURE (KELVIN) : NULL
REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS
REMARK 245 DETECTOR TYPE : GATAN K3 BIOQUANTUM (6K X
REMARK 245 4K)
REMARK 245 MINIMUM DEFOCUS (NM) : -800.00
REMARK 245 MAXIMUM DEFOCUS (NM) : 2200.00
REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 NOMINAL CS : 2.70
REMARK 245 IMAGING MODE : OTHER
REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 6499.00
REMARK 245 ILLUMINATION MODE : SPOT SCAN
REMARK 245 NOMINAL MAGNIFICATION : NULL
REMARK 245 CALIBRATED MAGNIFICATION : 10500
REMARK 245 SOURCE : OTHER
REMARK 245 ACCELERATION VOLTAGE (KV) : 300
REMARK 245 IMAGING DETAILS : NULL
REMARK 247
REMARK 247 ELECTRON MICROSCOPY
REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON
REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE
REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES
REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION
REMARK 247 OF THE STRUCTURE FACTORS.
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465 M RES C SSSEQI
REMARK 465 MET A -27
REMARK 465 SER A -26
REMARK 465 TYR A -25
REMARK 465 TYR A -24
REMARK 465 HIS A -23
REMARK 465 HIS A -22
REMARK 465 HIS A -21
REMARK 465 HIS A -20
REMARK 465 HIS A -19
REMARK 465 HIS A -18
REMARK 465 ASP A -17
REMARK 465 TYR A -16
REMARK 465 ASP A -15
REMARK 465 ILE A -14
REMARK 465 PRO A -13
REMARK 465 THR A -12
REMARK 465 THR A -11
REMARK 465 GLU A -10
REMARK 465 ASN A -9
REMARK 465 LEU A -8
REMARK 465 TYR A -7
REMARK 465 PHE A -6
REMARK 465 GLN A -5
REMARK 465 GLY A -4
REMARK 465 ALA A -3
REMARK 465 MET A -2
REMARK 465 GLY A -1
REMARK 465 SER A 0
REMARK 465 MET A 1
REMARK 465 ALA A 2
REMARK 465 THR A 3
REMARK 465 THR A 4
REMARK 465 GLY A 5
REMARK 465 THR A 6
REMARK 465 PRO A 7
REMARK 465 THR A 8
REMARK 465 ALA A 9
REMARK 465 ASP A 10
REMARK 465 ARG A 11
REMARK 465 GLY A 12
REMARK 465 ASP A 13
REMARK 465 ALA A 14
REMARK 465 ALA A 15
REMARK 465 ALA A 16
REMARK 465 THR A 17
REMARK 465 MET B 1
REMARK 465 GLU B 2
REMARK 465 LYS B 3
REMARK 465 LYS B 4
REMARK 465 GLU B 5
REMARK 465 CYS B 6
REMARK 465 PRO B 7
REMARK 465 GLU B 8
REMARK 465 LYS B 9
REMARK 465 SER B 10
REMARK 465 SER B 11
REMARK 465 SER B 12
REMARK 465 SER B 13
REMARK 465 GLU B 14
REMARK 465 GLU B 15
REMARK 465 GLU B 16
REMARK 465 LEU B 17
REMARK 465 PRO B 18
REMARK 465 ARG B 19
REMARK 465 ARG B 20
REMARK 465 ASP B 21
REMARK 465 SER B 22
REMARK 465 GLY B 23
REMARK 465 SER B 24
REMARK 465 SER B 25
REMARK 465 ARG B 26
REMARK 465 ASN B 27
REMARK 465 ILE B 28
REMARK 465 ASP B 29
REMARK 465 ALA B 30
REMARK 465 SER B 31
REMARK 465 LYS B 32
REMARK 465 LEU B 33
REMARK 465 ILE B 34
REMARK 465 ARG B 35
REMARK 465 LEU B 36
REMARK 465 GLN B 37
REMARK 465 GLY B 38
REMARK 465 SER B 39
REMARK 465 ARG B 40
REMARK 465 LYS B 41
REMARK 465 LEU B 42
REMARK 465 LEU B 43
REMARK 465 VAL B 44
REMARK 465 ASP B 45
REMARK 465 ASN B 46
REMARK 465 SER B 47
REMARK 465 ILE B 48
REMARK 465 ARG B 49
REMARK 465 GLU B 50
REMARK 465 LEU B 51
REMARK 465 GLN B 52
REMARK 465 TYR B 53
REMARK 465 THR B 54
REMARK 465 LYS B 55
REMARK 465 THR B 56
REMARK 465 GLY B 57
REMARK 465 ILE B 58
REMARK 465 PHE B 59
REMARK 465 PHE B 60
REMARK 465 GLN B 61
REMARK 465 ALA B 62
REMARK 465 GLU B 63
REMARK 465 ALA B 64
REMARK 465 CYS B 65
REMARK 465 VAL B 66
REMARK 465 THR B 67
REMARK 465 ASN B 68
REMARK 465 ASP B 69
REMARK 465 THR B 70
REMARK 465 VAL B 71
REMARK 465 TYR B 72
REMARK 465 ARG B 73
REMARK 465 GLU B 74
REMARK 465 LEU B 75
REMARK 465 PRO B 76
REMARK 465 CYS B 77
REMARK 465 VAL B 78
REMARK 465 SER B 79
REMARK 465 GLU B 80
REMARK 465 THR B 81
REMARK 465 LEU B 82
REMARK 465 CYS B 83
REMARK 465 ASP B 84
REMARK 465 ILE B 85
REMARK 465 SER B 86
REMARK 465 HIS B 87
REMARK 465 PHE B 88
REMARK 465 PHE B 89
REMARK 465 GLN B 90
REMARK 465 GLU B 91
REMARK 465 ASP B 92
REMARK 465 ASP B 93
REMARK 465 GLU B 94
REMARK 465 THR B 95
REMARK 465 GLU B 96
REMARK 465 ALA B 97
REMARK 465 GLU B 98
REMARK 465 PRO B 99
REMARK 465 LEU B 100
REMARK 465 LEU B 101
REMARK 465 PHE B 102
REMARK 465 ARG B 103
REMARK 465 ALA B 104
REMARK 465 VAL B 105
REMARK 465 PRO B 106
REMARK 465 GLU B 107
REMARK 465 CYS B 108
REMARK 465 GLN B 109
REMARK 465 LEU B 110
REMARK 465 SER B 111
REMARK 465 GLY B 112
REMARK 465 GLY B 113
REMARK 465 ASP B 114
REMARK 465 ILE B 115
REMARK 465 PRO B 116
REMARK 465 SER B 117
REMARK 465 VAL B 118
REMARK 465 SER B 119
REMARK 465 GLU B 120
REMARK 465 GLU B 121
REMARK 465 GLN B 122
REMARK 465 GLU B 123
REMARK 465 SER B 124
REMARK 465 SER B 125
REMARK 465 GLU B 126
REMARK 465 GLY B 127
REMARK 465 GLN B 128
REMARK 465 ASP B 129
REMARK 465 SER B 130
REMARK 465 GLY B 131
REMARK 465 ASP B 132
REMARK 465 ILE B 133
REMARK 465 CYS B 134
REMARK 465 SER B 135
REMARK 465 GLU B 136
REMARK 465 GLU B 137
REMARK 465 ASN B 138
REMARK 465 GLN B 139
REMARK 465 ILE B 140
REMARK 465 VAL B 141
REMARK 465 SER B 142
REMARK 465 SER B 143
REMARK 465 TYR B 144
REMARK 465 ALA B 145
REMARK 465 SER B 146
REMARK 465 LYS B 147
REMARK 465 VAL B 148
REMARK 465 CYS B 149
REMARK 465 PHE B 150
REMARK 465 GLU B 151
REMARK 465 ILE B 152
REMARK 465 GLU B 153
REMARK 465 GLU B 154
REMARK 465 ASP B 155
REMARK 465 TYR B 156
REMARK 465 LYS B 157
REMARK 465 ASN B 158
REMARK 465 ARG B 159
REMARK 465 GLN B 160
REMARK 465 PHE B 161
REMARK 465 LEU B 162
REMARK 465 GLY B 163
REMARK 465 PRO B 164
REMARK 465 GLU B 165
REMARK 465 PHE B 296
REMARK 465 SER B 297
REMARK 465 LEU B 298
REMARK 465 MET B 299
REMARK 465 GLY B 300
REMARK 465 ILE B 301
REMARK 465 LEU B 302
REMARK 465 LEU B 303
REMARK 465 PRO B 446
REMARK 465 PRO B 447
REMARK 465 PHE B 448
REMARK 465 SER B 449
REMARK 465 GLY B 450
REMARK 465 ALA B 451
REMARK 465 ALA B 452
REMARK 465 PHE B 453
REMARK 465 VAL B 454
REMARK 465 LYS B 455
REMARK 465 GLU B 456
REMARK 465 ASN B 457
REMARK 465 HIS B 458
REMARK 465 ARG B 459
REMARK 465 GLN B 460
REMARK 465 LEU B 461
REMARK 465 GLN B 462
REMARK 465 ALA B 463
REMARK 465 ARG B 464
REMARK 465 MET B 465
REMARK 465 GLY B 466
REMARK 465 ASP B 467
REMARK 465 LEU B 468
REMARK 465 LYS B 469
REMARK 465 GLY B 470
REMARK 465 VAL B 471
REMARK 465 LEU B 472
REMARK 465 ASP B 473
REMARK 465 ASP B 474
REMARK 465 LEU B 475
REMARK 465 GLN B 476
REMARK 465 ASP B 477
REMARK 465 ASN B 478
REMARK 465 GLU B 479
REMARK 465 VAL B 480
REMARK 465 LEU B 481
REMARK 465 THR B 482
REMARK 465 GLU B 483
REMARK 465 ASN B 484
REMARK 465 GLU B 485
REMARK 465 LYS B 486
REMARK 465 GLU B 487
REMARK 465 LEU B 488
REMARK 465 VAL B 489
REMARK 465 GLU B 490
REMARK 465 GLN B 491
REMARK 465 GLU B 492
REMARK 465 LYS B 493
REMARK 465 THR B 494
REMARK 465 ARG B 495
REMARK 465 GLN B 496
REMARK 465 SER B 497
REMARK 465 LYS B 498
REMARK 465 ASN B 499
REMARK 465 GLU B 500
REMARK 465 ALA B 501
REMARK 465 LEU B 502
REMARK 465 LEU B 503
REMARK 465 SER B 504
REMARK 465 MET B 505
REMARK 465 VAL B 506
REMARK 465 GLU B 507
REMARK 465 LYS B 508
REMARK 465 LYS B 509
REMARK 465 GLY B 510
REMARK 465 ASP B 511
REMARK 465 LEU B 512
REMARK 465 ALA B 513
REMARK 465 LEU B 514
REMARK 465 ASP B 515
REMARK 465 VAL B 516
REMARK 465 LEU B 517
REMARK 465 PHE B 518
REMARK 465 ARG B 519
REMARK 465 SER B 520
REMARK 465 ILE B 521
REMARK 465 SER B 522
REMARK 465 GLU B 523
REMARK 465 ARG B 524
REMARK 465 ASP B 525
REMARK 465 PRO B 526
REMARK 465 TYR B 527
REMARK 465 LEU B 528
REMARK 465 VAL B 529
REMARK 465 SER B 530
REMARK 465 TYR B 531
REMARK 465 LEU B 532
REMARK 465 ARG B 533
REMARK 465 GLN B 534
REMARK 465 GLN B 535
REMARK 465 ASN B 536
REMARK 465 LEU B 537
REMARK 465 MET C 1
REMARK 465 GLU C 2
REMARK 465 LYS C 3
REMARK 465 LYS C 4
REMARK 465 GLU C 5
REMARK 465 CYS C 6
REMARK 465 PRO C 7
REMARK 465 GLU C 8
REMARK 465 LYS C 9
REMARK 465 SER C 10
REMARK 465 SER C 11
REMARK 465 SER C 12
REMARK 465 SER C 13
REMARK 465 GLU C 14
REMARK 465 GLU C 15
REMARK 465 GLU C 16
REMARK 465 LEU C 17
REMARK 465 PRO C 18
REMARK 465 ARG C 19
REMARK 465 ARG C 20
REMARK 465 ASP C 21
REMARK 465 SER C 22
REMARK 465 GLY C 23
REMARK 465 SER C 24
REMARK 465 SER C 25
REMARK 465 ARG C 26
REMARK 465 ASN C 27
REMARK 465 ILE C 28
REMARK 465 ASP C 29
REMARK 465 ALA C 30
REMARK 465 SER C 31
REMARK 465 LYS C 32
REMARK 465 LEU C 33
REMARK 465 ILE C 34
REMARK 465 ARG C 35
REMARK 465 LEU C 36
REMARK 465 GLN C 37
REMARK 465 GLY C 38
REMARK 465 SER C 39
REMARK 465 ARG C 40
REMARK 465 LYS C 41
REMARK 465 LEU C 42
REMARK 465 LEU C 43
REMARK 465 VAL C 44
REMARK 465 ASP C 45
REMARK 465 ASN C 46
REMARK 465 SER C 47
REMARK 465 ILE C 48
REMARK 465 ARG C 49
REMARK 465 GLU C 50
REMARK 465 LEU C 51
REMARK 465 GLN C 52
REMARK 465 TYR C 53
REMARK 465 THR C 54
REMARK 465 LYS C 55
REMARK 465 THR C 56
REMARK 465 GLY C 57
REMARK 465 ILE C 58
REMARK 465 PHE C 59
REMARK 465 PHE C 60
REMARK 465 GLN C 61
REMARK 465 ALA C 62
REMARK 465 GLU C 63
REMARK 465 ALA C 64
REMARK 465 CYS C 65
REMARK 465 VAL C 66
REMARK 465 THR C 67
REMARK 465 ASN C 68
REMARK 465 ASP C 69
REMARK 465 THR C 70
REMARK 465 VAL C 71
REMARK 465 TYR C 72
REMARK 465 ARG C 73
REMARK 465 GLU C 74
REMARK 465 LEU C 75
REMARK 465 PRO C 76
REMARK 465 CYS C 77
REMARK 465 VAL C 78
REMARK 465 SER C 79
REMARK 465 GLU C 80
REMARK 465 THR C 81
REMARK 465 LEU C 82
REMARK 465 CYS C 83
REMARK 465 ASP C 84
REMARK 465 ILE C 85
REMARK 465 SER C 86
REMARK 465 HIS C 87
REMARK 465 PHE C 88
REMARK 465 PHE C 89
REMARK 465 GLN C 90
REMARK 465 GLU C 91
REMARK 465 ASP C 92
REMARK 465 ASP C 93
REMARK 465 GLU C 94
REMARK 465 THR C 95
REMARK 465 GLU C 96
REMARK 465 ALA C 97
REMARK 465 GLU C 98
REMARK 465 PRO C 99
REMARK 465 LEU C 100
REMARK 465 LEU C 101
REMARK 465 PHE C 102
REMARK 465 ARG C 103
REMARK 465 ALA C 104
REMARK 465 VAL C 105
REMARK 465 PRO C 106
REMARK 465 GLU C 107
REMARK 465 CYS C 108
REMARK 465 GLN C 109
REMARK 465 LEU C 110
REMARK 465 SER C 111
REMARK 465 GLY C 112
REMARK 465 GLY C 113
REMARK 465 ASP C 114
REMARK 465 ILE C 115
REMARK 465 PRO C 116
REMARK 465 SER C 117
REMARK 465 VAL C 118
REMARK 465 SER C 119
REMARK 465 GLU C 120
REMARK 465 GLU C 121
REMARK 465 GLN C 122
REMARK 465 GLU C 123
REMARK 465 SER C 124
REMARK 465 SER C 125
REMARK 465 GLU C 126
REMARK 465 GLY C 127
REMARK 465 GLN C 128
REMARK 465 ASP C 129
REMARK 465 SER C 130
REMARK 465 GLY C 131
REMARK 465 ASP C 132
REMARK 465 ILE C 133
REMARK 465 CYS C 134
REMARK 465 SER C 135
REMARK 465 GLU C 136
REMARK 465 GLU C 137
REMARK 465 ASN C 138
REMARK 465 GLN C 139
REMARK 465 ILE C 140
REMARK 465 VAL C 141
REMARK 465 SER C 142
REMARK 465 SER C 143
REMARK 465 TYR C 144
REMARK 465 ALA C 145
REMARK 465 SER C 146
REMARK 465 LYS C 147
REMARK 465 VAL C 148
REMARK 465 CYS C 149
REMARK 465 PHE C 150
REMARK 465 GLU C 151
REMARK 465 ILE C 152
REMARK 465 GLU C 153
REMARK 465 GLU C 154
REMARK 465 ASP C 155
REMARK 465 TYR C 156
REMARK 465 LYS C 157
REMARK 465 ASN C 158
REMARK 465 ARG C 159
REMARK 465 GLN C 160
REMARK 465 PHE C 161
REMARK 465 LEU C 162
REMARK 465 GLY C 163
REMARK 465 PRO C 164
REMARK 465 GLU C 165
REMARK 465 GLY C 166
REMARK 465 ASN C 167
REMARK 465 VAL C 168
REMARK 465 ASP C 169
REMARK 465 VAL C 170
REMARK 465 GLU C 171
REMARK 465 LEU C 172
REMARK 465 ILE C 173
REMARK 465 ASP C 174
REMARK 465 LYS C 175
REMARK 465 SER C 176
REMARK 465 THR C 177
REMARK 465 ASN C 178
REMARK 465 ARG C 179
REMARK 465 TYR C 180
REMARK 465 SER C 181
REMARK 465 VAL C 182
REMARK 465 TRP C 183
REMARK 465 PHE C 184
REMARK 465 PRO C 185
REMARK 465 THR C 186
REMARK 465 ALA C 187
REMARK 465 GLY C 188
REMARK 465 TRP C 189
REMARK 465 TYR C 190
REMARK 465 LEU C 191
REMARK 465 TRP C 192
REMARK 465 SER C 193
REMARK 465 ALA C 194
REMARK 465 THR C 195
REMARK 465 GLY C 196
REMARK 465 LEU C 197
REMARK 465 GLY C 198
REMARK 465 PHE C 199
REMARK 465 LEU C 200
REMARK 465 VAL C 201
REMARK 465 ARG C 202
REMARK 465 ASP C 203
REMARK 465 GLU C 204
REMARK 465 VAL C 205
REMARK 465 THR C 206
REMARK 465 VAL C 207
REMARK 465 THR C 208
REMARK 465 ILE C 209
REMARK 465 ALA C 210
REMARK 465 PHE C 211
REMARK 465 GLY C 212
REMARK 465 SER C 213
REMARK 465 TRP C 214
REMARK 465 SER C 215
REMARK 465 GLN C 216
REMARK 465 HIS C 217
REMARK 465 LEU C 218
REMARK 465 ALA C 219
REMARK 465 LEU C 220
REMARK 465 ASP C 221
REMARK 465 LEU C 222
REMARK 465 GLN C 223
REMARK 465 HIS C 224
REMARK 465 HIS C 225
REMARK 465 GLU C 226
REMARK 465 GLN C 227
REMARK 465 TRP C 228
REMARK 465 LEU C 229
REMARK 465 VAL C 230
REMARK 465 GLY C 231
REMARK 465 GLY C 232
REMARK 465 PRO C 233
REMARK 465 LEU C 234
REMARK 465 PHE C 235
REMARK 465 ASP C 236
REMARK 465 VAL C 237
REMARK 465 THR C 238
REMARK 465 ALA C 239
REMARK 465 GLU C 240
REMARK 465 PRO C 241
REMARK 465 GLU C 242
REMARK 465 GLU C 243
REMARK 465 ALA C 244
REMARK 465 VAL C 245
REMARK 465 ALA C 246
REMARK 465 GLU C 247
REMARK 465 ILE C 248
REMARK 465 HIS C 249
REMARK 465 LEU C 250
REMARK 465 PRO C 251
REMARK 465 HIS C 252
REMARK 465 PHE C 253
REMARK 465 ILE C 254
REMARK 465 SER C 255
REMARK 465 LEU C 256
REMARK 465 GLN C 257
REMARK 465 ALA C 258
REMARK 465 GLY C 259
REMARK 465 GLU C 260
REMARK 465 VAL C 261
REMARK 465 ASP C 262
REMARK 465 VAL C 263
REMARK 465 SER C 264
REMARK 465 TRP C 265
REMARK 465 PHE C 266
REMARK 465 LEU C 267
REMARK 465 VAL C 268
REMARK 465 ALA C 269
REMARK 465 HIS C 270
REMARK 465 PHE C 271
REMARK 465 LYS C 272
REMARK 465 ASN C 273
REMARK 465 GLU C 274
REMARK 465 GLY C 275
REMARK 465 MET C 276
REMARK 465 VAL C 277
REMARK 465 LEU C 278
REMARK 465 GLU C 279
REMARK 465 HIS C 280
REMARK 465 PRO C 281
REMARK 465 ALA C 282
REMARK 465 ARG C 283
REMARK 465 VAL C 284
REMARK 465 GLU C 285
REMARK 465 PRO C 286
REMARK 465 PHE C 287
REMARK 465 TYR C 288
REMARK 465 ALA C 289
REMARK 465 VAL C 290
REMARK 465 LEU C 291
REMARK 465 GLU C 292
REMARK 465 SER C 293
REMARK 465 PRO C 294
REMARK 465 SER C 295
REMARK 465 PHE C 296
REMARK 465 SER C 297
REMARK 465 LEU C 298
REMARK 465 MET C 299
REMARK 465 GLY C 300
REMARK 465 ILE C 301
REMARK 465 LEU C 302
REMARK 465 LEU C 303
REMARK 465 ARG C 304
REMARK 465 ILE C 305
REMARK 465 ALA C 306
REMARK 465 SER C 307
REMARK 465 GLY C 308
REMARK 465 THR C 309
REMARK 465 ARG C 310
REMARK 465 LEU C 311
REMARK 465 SER C 312
REMARK 465 ILE C 313
REMARK 465 PRO C 314
REMARK 465 ILE C 315
REMARK 465 THR C 316
REMARK 465 SER C 317
REMARK 465 ASN C 318
REMARK 465 THR C 319
REMARK 465 PRO C 447
REMARK 465 PHE C 448
REMARK 465 SER C 449
REMARK 465 GLY C 450
REMARK 465 ALA C 451
REMARK 465 ALA C 452
REMARK 465 PHE C 453
REMARK 465 VAL C 454
REMARK 465 LYS C 455
REMARK 465 GLU C 456
REMARK 465 ASN C 457
REMARK 465 HIS C 458
REMARK 465 ARG C 459
REMARK 465 GLN C 460
REMARK 465 LEU C 461
REMARK 465 GLN C 462
REMARK 465 ALA C 463
REMARK 465 ARG C 464
REMARK 465 MET C 465
REMARK 465 GLY C 466
REMARK 465 ASP C 467
REMARK 465 LEU C 468
REMARK 465 LYS C 469
REMARK 465 GLY C 470
REMARK 465 VAL C 471
REMARK 465 LEU C 472
REMARK 465 ASP C 473
REMARK 465 ASP C 474
REMARK 465 LEU C 475
REMARK 465 GLN C 476
REMARK 465 ASP C 477
REMARK 465 ASN C 478
REMARK 465 GLU C 479
REMARK 465 VAL C 480
REMARK 465 LEU C 481
REMARK 465 THR C 482
REMARK 465 GLU C 483
REMARK 465 ASN C 484
REMARK 465 GLU C 485
REMARK 465 LYS C 486
REMARK 465 GLU C 487
REMARK 465 LEU C 488
REMARK 465 VAL C 489
REMARK 465 GLU C 490
REMARK 465 GLN C 491
REMARK 465 GLU C 492
REMARK 465 LYS C 493
REMARK 465 THR C 494
REMARK 465 ARG C 495
REMARK 465 GLN C 496
REMARK 465 SER C 497
REMARK 465 LYS C 498
REMARK 465 ASN C 499
REMARK 465 GLU C 500
REMARK 465 ALA C 501
REMARK 465 LEU C 502
REMARK 465 LEU C 503
REMARK 465 SER C 504
REMARK 465 MET C 505
REMARK 465 VAL C 506
REMARK 465 GLU C 507
REMARK 465 LYS C 508
REMARK 465 LYS C 509
REMARK 465 GLY C 510
REMARK 465 ASP C 511
REMARK 465 LEU C 512
REMARK 465 ALA C 513
REMARK 465 LEU C 514
REMARK 465 ASP C 515
REMARK 465 VAL C 516
REMARK 465 LEU C 517
REMARK 465 PHE C 518
REMARK 465 ARG C 519
REMARK 465 SER C 520
REMARK 465 ILE C 521
REMARK 465 SER C 522
REMARK 465 GLU C 523
REMARK 465 ARG C 524
REMARK 465 ASP C 525
REMARK 465 PRO C 526
REMARK 465 TYR C 527
REMARK 465 LEU C 528
REMARK 465 VAL C 529
REMARK 465 SER C 530
REMARK 465 TYR C 531
REMARK 465 LEU C 532
REMARK 465 ARG C 533
REMARK 465 GLN C 534
REMARK 465 GLN C 535
REMARK 465 ASN C 536
REMARK 465 LEU C 537
REMARK 465 MET D -27
REMARK 465 SER D -26
REMARK 465 TYR D -25
REMARK 465 TYR D -24
REMARK 465 HIS D -23
REMARK 465 HIS D -22
REMARK 465 HIS D -21
REMARK 465 HIS D -20
REMARK 465 HIS D -19
REMARK 465 HIS D -18
REMARK 465 ASP D -17
REMARK 465 TYR D -16
REMARK 465 ASP D -15
REMARK 465 ILE D -14
REMARK 465 PRO D -13
REMARK 465 THR D -12
REMARK 465 THR D -11
REMARK 465 GLU D -10
REMARK 465 ASN D -9
REMARK 465 LEU D -8
REMARK 465 TYR D -7
REMARK 465 PHE D -6
REMARK 465 GLN D -5
REMARK 465 GLY D -4
REMARK 465 ALA D -3
REMARK 465 MET D -2
REMARK 465 GLY D -1
REMARK 465 SER D 0
REMARK 465 MET D 1
REMARK 465 ALA D 2
REMARK 465 THR D 3
REMARK 465 THR D 4
REMARK 465 GLY D 5
REMARK 465 THR D 6
REMARK 465 PRO D 7
REMARK 465 THR D 8
REMARK 465 ALA D 9
REMARK 465 ASP D 10
REMARK 465 ARG D 11
REMARK 465 GLY D 12
REMARK 465 ASP D 13
REMARK 465 ALA D 14
REMARK 465 ALA D 15
REMARK 465 ALA D 16
REMARK 465 THR D 17
REMARK 465 TYR D 44
REMARK 465 SER D 45
REMARK 465 GLY D 46
REMARK 465 LEU D 47
REMARK 465 ILE D 48
REMARK 465 VAL D 49
REMARK 465 ASN D 50
REMARK 465 LYS D 51
REMARK 465 ALA D 52
REMARK 465 MET D 77
REMARK 465 PRO D 78
REMARK 465 TYR D 79
REMARK 465 GLY D 80
REMARK 465 SER D 81
REMARK 465 ARG D 82
REMARK 465 GLU D 83
REMARK 465 ASN D 84
REMARK 465 SER D 85
REMARK 465 ASP D 110
REMARK 465 HIS D 111
REMARK 465 PHE D 112
REMARK 465 GLN D 113
REMARK 465 ALA D 114
REMARK 465 THR D 115
REMARK 465 PRO D 116
REMARK 465 HIS D 117
REMARK 465 HIS D 118
REMARK 465 GLY D 119
REMARK 465 VAL D 120
REMARK 465 TYR D 121
REMARK 465 SER D 122
REMARK 465 ARG D 123
REMARK 465 GLU D 124
REMARK 465 GLU D 125
REMARK 465 GLU D 126
REMARK 465 LEU D 127
REMARK 465 LEU D 128
REMARK 465 ARG D 129
REMARK 465 GLU D 130
REMARK 465 ARG D 131
REMARK 465 LYS D 132
REMARK 465 ARG D 133
REMARK 465 LEU D 134
REMARK 465 GLY D 135
REMARK 465 VAL D 136
REMARK 465 PHE D 137
REMARK 465 GLY D 138
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470 M RES CSSEQI ATOMS
REMARK 470 ASP A 18 CG OD1 OD2
REMARK 470 GLU A 64 CG CD OE1 OE2
REMARK 470 LEU A 233 CG CD1 CD2
REMARK 470 ASP A 234 CG OD1 OD2
REMARK 470 GLU A 265 CG CD OE1 OE2
REMARK 470 PHE B 211 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 ARG B 304 CG CD NE CZ NH1 NH2
REMARK 470 ILE B 305 CG1 CG2 CD1
REMARK 470 ILE B 315 CG1 CG2 CD1
REMARK 470 ASP D 18 CG OD1 OD2
REMARK 470 GLU D 64 CG CD OE1 OE2
REMARK 470 LEU D 233 CG CD1 CD2
REMARK 470 ASP D 234 CG OD1 OD2
REMARK 470 GLU D 265 CG CD OE1 OE2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE
REMARK 500 OG SER A 730 O16 GK2 A 901 1.34
REMARK 500 NE ARG A 131 OE1 GLU A 248 1.96
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3
REMARK 500 ASP A 251 CB - CG - OD2 ANGL. DEV. = 8.0 DEGREES
REMARK 500 ASP A 467 CB - CG - OD2 ANGL. DEV. = 6.3 DEGREES
REMARK 500 LEU C 334 CA - CB - CG ANGL. DEV. = 13.9 DEGREES
REMARK 500 PRO D 429 C - N - CD ANGL. DEV. = -25.7 DEGREES
REMARK 500 PRO D 429 CA - N - CD ANGL. DEV. = -11.9 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500 M RES CSSEQI PSI PHI
REMARK 500 SER A 156 -58.76 -29.75
REMARK 500 SER A 230 -155.08 -150.65
REMARK 500 ASP A 251 54.10 22.34
REMARK 500 GLU A 268 -62.85 -121.10
REMARK 500 GLU A 282 48.16 -94.35
REMARK 500 ALA A 316 148.92 -170.50
REMARK 500 LYS A 348 15.40 58.67
REMARK 500 TYR A 428 101.38 40.81
REMARK 500 GLU A 438 67.60 61.29
REMARK 500 GLU A 493 40.34 -98.78
REMARK 500 ASN A 695 -8.96 76.17
REMARK 500 SER A 730 -125.43 55.39
REMARK 500 MET A 771 -74.79 -100.75
REMARK 500 ASP A 772 -174.20 175.68
REMARK 500 ARG A 839 -79.57 -81.44
REMARK 500 HIS A 840 -51.47 -125.54
REMARK 500 LEU B 220 -1.42 69.13
REMARK 500 TRP B 228 54.15 -141.35
REMARK 500 GLU B 242 64.86 61.31
REMARK 500 SER B 293 73.10 52.94
REMARK 500 LEU B 320 28.62 -141.26
REMARK 500 TYR B 322 74.02 61.46
REMARK 500 TYR B 335 46.59 39.85
REMARK 500 TYR B 374 -167.93 -122.56
REMARK 500 LYS B 390 -162.24 -123.36
REMARK 500 LEU B 391 91.50 -68.08
REMARK 500 ARG B 394 65.51 60.71
REMARK 500 SER B 403 -166.48 -74.42
REMARK 500 TYR B 406 -178.59 -175.35
REMARK 500 LEU B 416 -5.77 72.72
REMARK 500 SER C 362 74.92 -117.11
REMARK 500 ARG C 394 37.74 39.59
REMARK 500 LEU C 416 -10.48 73.05
REMARK 500 ASN D 206 57.79 36.14
REMARK 500 SER D 230 -159.16 -151.50
REMARK 500 GLU D 268 -61.99 -120.25
REMARK 500 GLU D 282 48.35 -93.52
REMARK 500 ALA D 316 148.61 -171.56
REMARK 500 VAL D 419 -73.95 -106.91
REMARK 500 ASP D 425 49.02 -87.93
REMARK 500 PHE D 427 -51.11 -123.50
REMARK 500 TYR D 428 102.49 37.17
REMARK 500 GLU D 436 48.47 -68.22
REMARK 500 GLU D 438 71.52 56.64
REMARK 500 GLU D 493 41.54 -102.07
REMARK 500 HIS D 586 32.61 -99.65
REMARK 500 ARG D 685 21.47 -140.77
REMARK 500 GLN D 696 43.57 -143.32
REMARK 500 SER D 730 -113.36 56.88
REMARK 500 MET D 771 45.06 -104.82
REMARK 500
REMARK 500 THIS ENTRY HAS 55 RAMACHANDRAN OUTLIERS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS
REMARK 500
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH
REMARK 500 CIS AND TRANS CONFORMATION. CIS BONDS, IF ANY, ARE LISTED
REMARK 500 ON CISPEP RECORDS. TRANS IS DEFINED AS 180 +/- 30 AND
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.
REMARK 500 MODEL OMEGA
REMARK 500 ALA A 155 SER A 156 -129.78
REMARK 500 SER C 362 PRO C 363 -141.28
REMARK 500 MET D 771 ASP D 772 -131.82
REMARK 500
REMARK 500 REMARK: NULL
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: EMD-22402 RELATED DB: EMDB
REMARK 900 HUMAN DPP9-CARD8 COMPLEX
DBREF 7JN7 A 1 863 UNP Q86TI2 DPP9_HUMAN 1 863
DBREF 7JN7 B 1 537 UNP Q9Y2G2 CARD8_HUMAN 1 537
DBREF 7JN7 C 1 537 UNP Q9Y2G2 CARD8_HUMAN 1 537
DBREF 7JN7 D 1 863 UNP Q86TI2 DPP9_HUMAN 1 863
SEQADV 7JN7 MET A -27 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 SER A -26 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 TYR A -25 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 TYR A -24 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 HIS A -23 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 HIS A -22 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 HIS A -21 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 HIS A -20 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 HIS A -19 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 HIS A -18 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 ASP A -17 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 TYR A -16 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 ASP A -15 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 ILE A -14 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 PRO A -13 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 THR A -12 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 THR A -11 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 GLU A -10 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 ASN A -9 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 LEU A -8 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 TYR A -7 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 PHE A -6 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 GLN A -5 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 GLY A -4 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 ALA A -3 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 MET A -2 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 GLY A -1 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 SER A 0 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 MET D -27 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 SER D -26 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 TYR D -25 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 TYR D -24 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 HIS D -23 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 HIS D -22 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 HIS D -21 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 HIS D -20 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 HIS D -19 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 HIS D -18 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 ASP D -17 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 TYR D -16 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 ASP D -15 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 ILE D -14 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 PRO D -13 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 THR D -12 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 THR D -11 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 GLU D -10 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 ASN D -9 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 LEU D -8 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 TYR D -7 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 PHE D -6 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 GLN D -5 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 GLY D -4 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 ALA D -3 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 MET D -2 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 GLY D -1 UNP Q86TI2 EXPRESSION TAG
SEQADV 7JN7 SER D 0 UNP Q86TI2 EXPRESSION TAG
SEQRES 1 A 891 MET SER TYR TYR HIS HIS HIS HIS HIS HIS ASP TYR ASP
SEQRES 2 A 891 ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY ALA MET
SEQRES 3 A 891 GLY SER MET ALA THR THR GLY THR PRO THR ALA ASP ARG
SEQRES 4 A 891 GLY ASP ALA ALA ALA THR ASP ASP PRO ALA ALA ARG PHE
SEQRES 5 A 891 GLN VAL GLN LYS HIS SER TRP ASP GLY LEU ARG SER ILE
SEQRES 6 A 891 ILE HIS GLY SER ARG LYS TYR SER GLY LEU ILE VAL ASN
SEQRES 7 A 891 LYS ALA PRO HIS ASP PHE GLN PHE VAL GLN LYS THR ASP
SEQRES 8 A 891 GLU SER GLY PRO HIS SER HIS ARG LEU TYR TYR LEU GLY
SEQRES 9 A 891 MET PRO TYR GLY SER ARG GLU ASN SER LEU LEU TYR SER
SEQRES 10 A 891 GLU ILE PRO LYS LYS VAL ARG LYS GLU ALA LEU LEU LEU
SEQRES 11 A 891 LEU SER TRP LYS GLN MET LEU ASP HIS PHE GLN ALA THR
SEQRES 12 A 891 PRO HIS HIS GLY VAL TYR SER ARG GLU GLU GLU LEU LEU
SEQRES 13 A 891 ARG GLU ARG LYS ARG LEU GLY VAL PHE GLY ILE THR SER
SEQRES 14 A 891 TYR ASP PHE HIS SER GLU SER GLY LEU PHE LEU PHE GLN
SEQRES 15 A 891 ALA SER ASN SER LEU PHE HIS CYS ARG ASP GLY GLY LYS
SEQRES 16 A 891 ASN GLY PHE MET VAL SER PRO MET LYS PRO LEU GLU ILE
SEQRES 17 A 891 LYS THR GLN CYS SER GLY PRO ARG MET ASP PRO LYS ILE
SEQRES 18 A 891 CYS PRO ALA ASP PRO ALA PHE PHE SER PHE ILE ASN ASN
SEQRES 19 A 891 SER ASP LEU TRP VAL ALA ASN ILE GLU THR GLY GLU GLU
SEQRES 20 A 891 ARG ARG LEU THR PHE CYS HIS GLN GLY LEU SER ASN VAL
SEQRES 21 A 891 LEU ASP ASP PRO LYS SER ALA GLY VAL ALA THR PHE VAL
SEQRES 22 A 891 ILE GLN GLU GLU PHE ASP ARG PHE THR GLY TYR TRP TRP
SEQRES 23 A 891 CYS PRO THR ALA SER TRP GLU GLY SER GLU GLY LEU LYS
SEQRES 24 A 891 THR LEU ARG ILE LEU TYR GLU GLU VAL ASP GLU SER GLU
SEQRES 25 A 891 VAL GLU VAL ILE HIS VAL PRO SER PRO ALA LEU GLU GLU
SEQRES 26 A 891 ARG LYS THR ASP SER TYR ARG TYR PRO ARG THR GLY SER
SEQRES 27 A 891 LYS ASN PRO LYS ILE ALA LEU LYS LEU ALA GLU PHE GLN
SEQRES 28 A 891 THR ASP SER GLN GLY LYS ILE VAL SER THR GLN GLU LYS
SEQRES 29 A 891 GLU LEU VAL GLN PRO PHE SER SER LEU PHE PRO LYS VAL
SEQRES 30 A 891 GLU TYR ILE ALA ARG ALA GLY TRP THR ARG ASP GLY LYS
SEQRES 31 A 891 TYR ALA TRP ALA MET PHE LEU ASP ARG PRO GLN GLN TRP
SEQRES 32 A 891 LEU GLN LEU VAL LEU LEU PRO PRO ALA LEU PHE ILE PRO
SEQRES 33 A 891 SER THR GLU ASN GLU GLU GLN ARG LEU ALA SER ALA ARG
SEQRES 34 A 891 ALA VAL PRO ARG ASN VAL GLN PRO TYR VAL VAL TYR GLU
SEQRES 35 A 891 GLU VAL THR ASN VAL TRP ILE ASN VAL HIS ASP ILE PHE
SEQRES 36 A 891 TYR PRO PHE PRO GLN SER GLU GLY GLU ASP GLU LEU CYS
SEQRES 37 A 891 PHE LEU ARG ALA ASN GLU CYS LYS THR GLY PHE CYS HIS
SEQRES 38 A 891 LEU TYR LYS VAL THR ALA VAL LEU LYS SER GLN GLY TYR
SEQRES 39 A 891 ASP TRP SER GLU PRO PHE SER PRO GLY GLU ASP GLU PHE
SEQRES 40 A 891 LYS CYS PRO ILE LYS GLU GLU ILE ALA LEU THR SER GLY
SEQRES 41 A 891 GLU TRP GLU VAL LEU ALA ARG HIS GLY SER LYS ILE TRP
SEQRES 42 A 891 VAL ASN GLU GLU THR LYS LEU VAL TYR PHE GLN GLY THR
SEQRES 43 A 891 LYS ASP THR PRO LEU GLU HIS HIS LEU TYR VAL VAL SER
SEQRES 44 A 891 TYR GLU ALA ALA GLY GLU ILE VAL ARG LEU THR THR PRO
SEQRES 45 A 891 GLY PHE SER HIS SER CYS SER MET SER GLN ASN PHE ASP
SEQRES 46 A 891 MET PHE VAL SER HIS TYR SER SER VAL SER THR PRO PRO
SEQRES 47 A 891 CYS VAL HIS VAL TYR LYS LEU SER GLY PRO ASP ASP ASP
SEQRES 48 A 891 PRO LEU HIS LYS GLN PRO ARG PHE TRP ALA SER MET MET
SEQRES 49 A 891 GLU ALA ALA SER CYS PRO PRO ASP TYR VAL PRO PRO GLU
SEQRES 50 A 891 ILE PHE HIS PHE HIS THR ARG SER ASP VAL ARG LEU TYR
SEQRES 51 A 891 GLY MET ILE TYR LYS PRO HIS ALA LEU GLN PRO GLY LYS
SEQRES 52 A 891 LYS HIS PRO THR VAL LEU PHE VAL TYR GLY GLY PRO GLN
SEQRES 53 A 891 VAL GLN LEU VAL ASN ASN SER PHE LYS GLY ILE LYS TYR
SEQRES 54 A 891 LEU ARG LEU ASN THR LEU ALA SER LEU GLY TYR ALA VAL
SEQRES 55 A 891 VAL VAL ILE ASP GLY ARG GLY SER CYS GLN ARG GLY LEU
SEQRES 56 A 891 ARG PHE GLU GLY ALA LEU LYS ASN GLN MET GLY GLN VAL
SEQRES 57 A 891 GLU ILE GLU ASP GLN VAL GLU GLY LEU GLN PHE VAL ALA
SEQRES 58 A 891 GLU LYS TYR GLY PHE ILE ASP LEU SER ARG VAL ALA ILE
SEQRES 59 A 891 HIS GLY TRP SER TYR GLY GLY PHE LEU SER LEU MET GLY
SEQRES 60 A 891 LEU ILE HIS LYS PRO GLN VAL PHE LYS VAL ALA ILE ALA
SEQRES 61 A 891 GLY ALA PRO VAL THR VAL TRP MET ALA TYR ASP THR GLY
SEQRES 62 A 891 TYR THR GLU ARG TYR MET ASP VAL PRO GLU ASN ASN GLN
SEQRES 63 A 891 HIS GLY TYR GLU ALA GLY SER VAL ALA LEU HIS VAL GLU
SEQRES 64 A 891 LYS LEU PRO ASN GLU PRO ASN ARG LEU LEU ILE LEU HIS
SEQRES 65 A 891 GLY PHE LEU ASP GLU ASN VAL HIS PHE PHE HIS THR ASN
SEQRES 66 A 891 PHE LEU VAL SER GLN LEU ILE ARG ALA GLY LYS PRO TYR
SEQRES 67 A 891 GLN LEU GLN ILE TYR PRO ASN GLU ARG HIS SER ILE ARG
SEQRES 68 A 891 CYS PRO GLU SER GLY GLU HIS TYR GLU VAL THR LEU LEU
SEQRES 69 A 891 HIS PHE LEU GLN GLU TYR LEU
SEQRES 1 B 537 MET GLU LYS LYS GLU CYS PRO GLU LYS SER SER SER SER
SEQRES 2 B 537 GLU GLU GLU LEU PRO ARG ARG ASP SER GLY SER SER ARG
SEQRES 3 B 537 ASN ILE ASP ALA SER LYS LEU ILE ARG LEU GLN GLY SER
SEQRES 4 B 537 ARG LYS LEU LEU VAL ASP ASN SER ILE ARG GLU LEU GLN
SEQRES 5 B 537 TYR THR LYS THR GLY ILE PHE PHE GLN ALA GLU ALA CYS
SEQRES 6 B 537 VAL THR ASN ASP THR VAL TYR ARG GLU LEU PRO CYS VAL
SEQRES 7 B 537 SER GLU THR LEU CYS ASP ILE SER HIS PHE PHE GLN GLU
SEQRES 8 B 537 ASP ASP GLU THR GLU ALA GLU PRO LEU LEU PHE ARG ALA
SEQRES 9 B 537 VAL PRO GLU CYS GLN LEU SER GLY GLY ASP ILE PRO SER
SEQRES 10 B 537 VAL SER GLU GLU GLN GLU SER SER GLU GLY GLN ASP SER
SEQRES 11 B 537 GLY ASP ILE CYS SER GLU GLU ASN GLN ILE VAL SER SER
SEQRES 12 B 537 TYR ALA SER LYS VAL CYS PHE GLU ILE GLU GLU ASP TYR
SEQRES 13 B 537 LYS ASN ARG GLN PHE LEU GLY PRO GLU GLY ASN VAL ASP
SEQRES 14 B 537 VAL GLU LEU ILE ASP LYS SER THR ASN ARG TYR SER VAL
SEQRES 15 B 537 TRP PHE PRO THR ALA GLY TRP TYR LEU TRP SER ALA THR
SEQRES 16 B 537 GLY LEU GLY PHE LEU VAL ARG ASP GLU VAL THR VAL THR
SEQRES 17 B 537 ILE ALA PHE GLY SER TRP SER GLN HIS LEU ALA LEU ASP
SEQRES 18 B 537 LEU GLN HIS HIS GLU GLN TRP LEU VAL GLY GLY PRO LEU
SEQRES 19 B 537 PHE ASP VAL THR ALA GLU PRO GLU GLU ALA VAL ALA GLU
SEQRES 20 B 537 ILE HIS LEU PRO HIS PHE ILE SER LEU GLN ALA GLY GLU
SEQRES 21 B 537 VAL ASP VAL SER TRP PHE LEU VAL ALA HIS PHE LYS ASN
SEQRES 22 B 537 GLU GLY MET VAL LEU GLU HIS PRO ALA ARG VAL GLU PRO
SEQRES 23 B 537 PHE TYR ALA VAL LEU GLU SER PRO SER PHE SER LEU MET
SEQRES 24 B 537 GLY ILE LEU LEU ARG ILE ALA SER GLY THR ARG LEU SER
SEQRES 25 B 537 ILE PRO ILE THR SER ASN THR LEU ILE TYR TYR HIS PRO
SEQRES 26 B 537 HIS PRO GLU ASP ILE LYS PHE HIS LEU TYR LEU VAL PRO
SEQRES 27 B 537 SER ASP ALA LEU LEU THR LYS ALA ILE ASP ASP GLU GLU
SEQRES 28 B 537 ASP ARG PHE HIS GLY VAL ARG LEU GLN THR SER PRO PRO
SEQRES 29 B 537 MET GLU PRO LEU ASN PHE GLY SER SER TYR ILE VAL SER
SEQRES 30 B 537 ASN SER ALA ASN LEU LYS VAL MET PRO LYS GLU LEU LYS
SEQRES 31 B 537 LEU SER TYR ARG SER PRO GLY GLU ILE GLN HIS PHE SER
SEQRES 32 B 537 LYS PHE TYR ALA GLY GLN MET LYS GLU PRO ILE GLN LEU
SEQRES 33 B 537 GLU ILE THR GLU LYS ARG HIS GLY THR LEU VAL TRP ASP
SEQRES 34 B 537 THR GLU VAL LYS PRO VAL ASP LEU GLN LEU VAL ALA ALA
SEQRES 35 B 537 SER ALA PRO PRO PRO PHE SER GLY ALA ALA PHE VAL LYS
SEQRES 36 B 537 GLU ASN HIS ARG GLN LEU GLN ALA ARG MET GLY ASP LEU
SEQRES 37 B 537 LYS GLY VAL LEU ASP ASP LEU GLN ASP ASN GLU VAL LEU
SEQRES 38 B 537 THR GLU ASN GLU LYS GLU LEU VAL GLU GLN GLU LYS THR
SEQRES 39 B 537 ARG GLN SER LYS ASN GLU ALA LEU LEU SER MET VAL GLU
SEQRES 40 B 537 LYS LYS GLY ASP LEU ALA LEU ASP VAL LEU PHE ARG SER
SEQRES 41 B 537 ILE SER GLU ARG ASP PRO TYR LEU VAL SER TYR LEU ARG
SEQRES 42 B 537 GLN GLN ASN LEU
SEQRES 1 C 537 MET GLU LYS LYS GLU CYS PRO GLU LYS SER SER SER SER
SEQRES 2 C 537 GLU GLU GLU LEU PRO ARG ARG ASP SER GLY SER SER ARG
SEQRES 3 C 537 ASN ILE ASP ALA SER LYS LEU ILE ARG LEU GLN GLY SER
SEQRES 4 C 537 ARG LYS LEU LEU VAL ASP ASN SER ILE ARG GLU LEU GLN
SEQRES 5 C 537 TYR THR LYS THR GLY ILE PHE PHE GLN ALA GLU ALA CYS
SEQRES 6 C 537 VAL THR ASN ASP THR VAL TYR ARG GLU LEU PRO CYS VAL
SEQRES 7 C 537 SER GLU THR LEU CYS ASP ILE SER HIS PHE PHE GLN GLU
SEQRES 8 C 537 ASP ASP GLU THR GLU ALA GLU PRO LEU LEU PHE ARG ALA
SEQRES 9 C 537 VAL PRO GLU CYS GLN LEU SER GLY GLY ASP ILE PRO SER
SEQRES 10 C 537 VAL SER GLU GLU GLN GLU SER SER GLU GLY GLN ASP SER
SEQRES 11 C 537 GLY ASP ILE CYS SER GLU GLU ASN GLN ILE VAL SER SER
SEQRES 12 C 537 TYR ALA SER LYS VAL CYS PHE GLU ILE GLU GLU ASP TYR
SEQRES 13 C 537 LYS ASN ARG GLN PHE LEU GLY PRO GLU GLY ASN VAL ASP
SEQRES 14 C 537 VAL GLU LEU ILE ASP LYS SER THR ASN ARG TYR SER VAL
SEQRES 15 C 537 TRP PHE PRO THR ALA GLY TRP TYR LEU TRP SER ALA THR
SEQRES 16 C 537 GLY LEU GLY PHE LEU VAL ARG ASP GLU VAL THR VAL THR
SEQRES 17 C 537 ILE ALA PHE GLY SER TRP SER GLN HIS LEU ALA LEU ASP
SEQRES 18 C 537 LEU GLN HIS HIS GLU GLN TRP LEU VAL GLY GLY PRO LEU
SEQRES 19 C 537 PHE ASP VAL THR ALA GLU PRO GLU GLU ALA VAL ALA GLU
SEQRES 20 C 537 ILE HIS LEU PRO HIS PHE ILE SER LEU GLN ALA GLY GLU
SEQRES 21 C 537 VAL ASP VAL SER TRP PHE LEU VAL ALA HIS PHE LYS ASN
SEQRES 22 C 537 GLU GLY MET VAL LEU GLU HIS PRO ALA ARG VAL GLU PRO
SEQRES 23 C 537 PHE TYR ALA VAL LEU GLU SER PRO SER PHE SER LEU MET
SEQRES 24 C 537 GLY ILE LEU LEU ARG ILE ALA SER GLY THR ARG LEU SER
SEQRES 25 C 537 ILE PRO ILE THR SER ASN THR LEU ILE TYR TYR HIS PRO
SEQRES 26 C 537 HIS PRO GLU ASP ILE LYS PHE HIS LEU TYR LEU VAL PRO
SEQRES 27 C 537 SER ASP ALA LEU LEU THR LYS ALA ILE ASP ASP GLU GLU
SEQRES 28 C 537 ASP ARG PHE HIS GLY VAL ARG LEU GLN THR SER PRO PRO
SEQRES 29 C 537 MET GLU PRO LEU ASN PHE GLY SER SER TYR ILE VAL SER
SEQRES 30 C 537 ASN SER ALA ASN LEU LYS VAL MET PRO LYS GLU LEU LYS
SEQRES 31 C 537 LEU SER TYR ARG SER PRO GLY GLU ILE GLN HIS PHE SER
SEQRES 32 C 537 LYS PHE TYR ALA GLY GLN MET LYS GLU PRO ILE GLN LEU
SEQRES 33 C 537 GLU ILE THR GLU LYS ARG HIS GLY THR LEU VAL TRP ASP
SEQRES 34 C 537 THR GLU VAL LYS PRO VAL ASP LEU GLN LEU VAL ALA ALA
SEQRES 35 C 537 SER ALA PRO PRO PRO PHE SER GLY ALA ALA PHE VAL LYS
SEQRES 36 C 537 GLU ASN HIS ARG GLN LEU GLN ALA ARG MET GLY ASP LEU
SEQRES 37 C 537 LYS GLY VAL LEU ASP ASP LEU GLN ASP ASN GLU VAL LEU
SEQRES 38 C 537 THR GLU ASN GLU LYS GLU LEU VAL GLU GLN GLU LYS THR
SEQRES 39 C 537 ARG GLN SER LYS ASN GLU ALA LEU LEU SER MET VAL GLU
SEQRES 40 C 537 LYS LYS GLY ASP LEU ALA LEU ASP VAL LEU PHE ARG SER
SEQRES 41 C 537 ILE SER GLU ARG ASP PRO TYR LEU VAL SER TYR LEU ARG
SEQRES 42 C 537 GLN GLN ASN LEU
SEQRES 1 D 891 MET SER TYR TYR HIS HIS HIS HIS HIS HIS ASP TYR ASP
SEQRES 2 D 891 ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY ALA MET
SEQRES 3 D 891 GLY SER MET ALA THR THR GLY THR PRO THR ALA ASP ARG
SEQRES 4 D 891 GLY ASP ALA ALA ALA THR ASP ASP PRO ALA ALA ARG PHE
SEQRES 5 D 891 GLN VAL GLN LYS HIS SER TRP ASP GLY LEU ARG SER ILE
SEQRES 6 D 891 ILE HIS GLY SER ARG LYS TYR SER GLY LEU ILE VAL ASN
SEQRES 7 D 891 LYS ALA PRO HIS ASP PHE GLN PHE VAL GLN LYS THR ASP
SEQRES 8 D 891 GLU SER GLY PRO HIS SER HIS ARG LEU TYR TYR LEU GLY
SEQRES 9 D 891 MET PRO TYR GLY SER ARG GLU ASN SER LEU LEU TYR SER
SEQRES 10 D 891 GLU ILE PRO LYS LYS VAL ARG LYS GLU ALA LEU LEU LEU
SEQRES 11 D 891 LEU SER TRP LYS GLN MET LEU ASP HIS PHE GLN ALA THR
SEQRES 12 D 891 PRO HIS HIS GLY VAL TYR SER ARG GLU GLU GLU LEU LEU
SEQRES 13 D 891 ARG GLU ARG LYS ARG LEU GLY VAL PHE GLY ILE THR SER
SEQRES 14 D 891 TYR ASP PHE HIS SER GLU SER GLY LEU PHE LEU PHE GLN
SEQRES 15 D 891 ALA SER ASN SER LEU PHE HIS CYS ARG ASP GLY GLY LYS
SEQRES 16 D 891 ASN GLY PHE MET VAL SER PRO MET LYS PRO LEU GLU ILE
SEQRES 17 D 891 LYS THR GLN CYS SER GLY PRO ARG MET ASP PRO LYS ILE
SEQRES 18 D 891 CYS PRO ALA ASP PRO ALA PHE PHE SER PHE ILE ASN ASN
SEQRES 19 D 891 SER ASP LEU TRP VAL ALA ASN ILE GLU THR GLY GLU GLU
SEQRES 20 D 891 ARG ARG LEU THR PHE CYS HIS GLN GLY LEU SER ASN VAL
SEQRES 21 D 891 LEU ASP ASP PRO LYS SER ALA GLY VAL ALA THR PHE VAL
SEQRES 22 D 891 ILE GLN GLU GLU PHE ASP ARG PHE THR GLY TYR TRP TRP
SEQRES 23 D 891 CYS PRO THR ALA SER TRP GLU GLY SER GLU GLY LEU LYS
SEQRES 24 D 891 THR LEU ARG ILE LEU TYR GLU GLU VAL ASP GLU SER GLU
SEQRES 25 D 891 VAL GLU VAL ILE HIS VAL PRO SER PRO ALA LEU GLU GLU
SEQRES 26 D 891 ARG LYS THR ASP SER TYR ARG TYR PRO ARG THR GLY SER
SEQRES 27 D 891 LYS ASN PRO LYS ILE ALA LEU LYS LEU ALA GLU PHE GLN
SEQRES 28 D 891 THR ASP SER GLN GLY LYS ILE VAL SER THR GLN GLU LYS
SEQRES 29 D 891 GLU LEU VAL GLN PRO PHE SER SER LEU PHE PRO LYS VAL
SEQRES 30 D 891 GLU TYR ILE ALA ARG ALA GLY TRP THR ARG ASP GLY LYS
SEQRES 31 D 891 TYR ALA TRP ALA MET PHE LEU ASP ARG PRO GLN GLN TRP
SEQRES 32 D 891 LEU GLN LEU VAL LEU LEU PRO PRO ALA LEU PHE ILE PRO
SEQRES 33 D 891 SER THR GLU ASN GLU GLU GLN ARG LEU ALA SER ALA ARG
SEQRES 34 D 891 ALA VAL PRO ARG ASN VAL GLN PRO TYR VAL VAL TYR GLU
SEQRES 35 D 891 GLU VAL THR ASN VAL TRP ILE ASN VAL HIS ASP ILE PHE
SEQRES 36 D 891 TYR PRO PHE PRO GLN SER GLU GLY GLU ASP GLU LEU CYS
SEQRES 37 D 891 PHE LEU ARG ALA ASN GLU CYS LYS THR GLY PHE CYS HIS
SEQRES 38 D 891 LEU TYR LYS VAL THR ALA VAL LEU LYS SER GLN GLY TYR
SEQRES 39 D 891 ASP TRP SER GLU PRO PHE SER PRO GLY GLU ASP GLU PHE
SEQRES 40 D 891 LYS CYS PRO ILE LYS GLU GLU ILE ALA LEU THR SER GLY
SEQRES 41 D 891 GLU TRP GLU VAL LEU ALA ARG HIS GLY SER LYS ILE TRP
SEQRES 42 D 891 VAL ASN GLU GLU THR LYS LEU VAL TYR PHE GLN GLY THR
SEQRES 43 D 891 LYS ASP THR PRO LEU GLU HIS HIS LEU TYR VAL VAL SER
SEQRES 44 D 891 TYR GLU ALA ALA GLY GLU ILE VAL ARG LEU THR THR PRO
SEQRES 45 D 891 GLY PHE SER HIS SER CYS SER MET SER GLN ASN PHE ASP
SEQRES 46 D 891 MET PHE VAL SER HIS TYR SER SER VAL SER THR PRO PRO
SEQRES 47 D 891 CYS VAL HIS VAL TYR LYS LEU SER GLY PRO ASP ASP ASP
SEQRES 48 D 891 PRO LEU HIS LYS GLN PRO ARG PHE TRP ALA SER MET MET
SEQRES 49 D 891 GLU ALA ALA SER CYS PRO PRO ASP TYR VAL PRO PRO GLU
SEQRES 50 D 891 ILE PHE HIS PHE HIS THR ARG SER ASP VAL ARG LEU TYR
SEQRES 51 D 891 GLY MET ILE TYR LYS PRO HIS ALA LEU GLN PRO GLY LYS
SEQRES 52 D 891 LYS HIS PRO THR VAL LEU PHE VAL TYR GLY GLY PRO GLN
SEQRES 53 D 891 VAL GLN LEU VAL ASN ASN SER PHE LYS GLY ILE LYS TYR
SEQRES 54 D 891 LEU ARG LEU ASN THR LEU ALA SER LEU GLY TYR ALA VAL
SEQRES 55 D 891 VAL VAL ILE ASP GLY ARG GLY SER CYS GLN ARG GLY LEU
SEQRES 56 D 891 ARG PHE GLU GLY ALA LEU LYS ASN GLN MET GLY GLN VAL
SEQRES 57 D 891 GLU ILE GLU ASP GLN VAL GLU GLY LEU GLN PHE VAL ALA
SEQRES 58 D 891 GLU LYS TYR GLY PHE ILE ASP LEU SER ARG VAL ALA ILE
SEQRES 59 D 891 HIS GLY TRP SER TYR GLY GLY PHE LEU SER LEU MET GLY
SEQRES 60 D 891 LEU ILE HIS LYS PRO GLN VAL PHE LYS VAL ALA ILE ALA
SEQRES 61 D 891 GLY ALA PRO VAL THR VAL TRP MET ALA TYR ASP THR GLY
SEQRES 62 D 891 TYR THR GLU ARG TYR MET ASP VAL PRO GLU ASN ASN GLN
SEQRES 63 D 891 HIS GLY TYR GLU ALA GLY SER VAL ALA LEU HIS VAL GLU
SEQRES 64 D 891 LYS LEU PRO ASN GLU PRO ASN ARG LEU LEU ILE LEU HIS
SEQRES 65 D 891 GLY PHE LEU ASP GLU ASN VAL HIS PHE PHE HIS THR ASN
SEQRES 66 D 891 PHE LEU VAL SER GLN LEU ILE ARG ALA GLY LYS PRO TYR
SEQRES 67 D 891 GLN LEU GLN ILE TYR PRO ASN GLU ARG HIS SER ILE ARG
SEQRES 68 D 891 CYS PRO GLU SER GLY GLU HIS TYR GLU VAL THR LEU LEU
SEQRES 69 D 891 HIS PHE LEU GLN GLU TYR LEU
HET GK2 A 901 15
HET GK2 D 901 15
HETNAM GK2 [(2~{R})-1-[(2~{R})-2-AZANYL-3-METHYL-
HETNAM 2 GK2 BUTANOYL]PYRROLIDIN-2-YL]BORONIC ACID
FORMUL 5 GK2 2(C9 H19 B N2 O3)
HELIX 1 AA1 ASP A 19 ARG A 23 5 5
HELIX 2 AA2 SER A 30 ARG A 42 1 13
HELIX 3 AA3 TYR A 44 VAL A 49 1 6
HELIX 4 AA4 PRO A 116 VAL A 120 5 5
HELIX 5 AA5 SER A 122 LYS A 132 1 11
HELIX 6 AA6 THR A 243 PHE A 250 1 8
HELIX 7 AA7 PRO A 341 PHE A 346 1 6
HELIX 8 AA8 PRO A 382 ALA A 384 5 3
HELIX 9 AA9 ASN A 392 VAL A 403 1 12
HELIX 10 AB1 GLU A 446 GLY A 450 1 5
HELIX 11 AB2 TYR A 661 GLY A 671 1 11
HELIX 12 AB3 GLY A 686 GLY A 691 1 6
HELIX 13 AB4 ALA A 692 LYS A 694 5 3
HELIX 14 AB5 VAL A 700 TYR A 716 1 17
HELIX 15 AB6 SER A 730 LYS A 743 1 14
HELIX 16 AB7 ASP A 763 MET A 771 1 9
HELIX 17 AB8 GLN A 778 GLY A 784 1 7
HELIX 18 AB9 SER A 785 LEU A 793 5 9
HELIX 19 AC1 HIS A 812 GLY A 827 1 16
HELIX 20 AC2 CYS A 844 LEU A 863 1 20
HELIX 21 AC3 SER B 317 ILE B 321 5 5
HELIX 22 AC4 ASP B 348 LEU B 359 1 12
HELIX 23 AC5 GLN B 360 SER B 362 5 3
HELIX 24 AC6 ASP C 348 LEU C 359 1 12
HELIX 25 AC7 SER D 30 ARG D 42 1 13
HELIX 26 AC8 THR D 243 PHE D 250 1 8
HELIX 27 AC9 ALA D 294 ARG D 298 5 5
HELIX 28 AD1 PRO D 341 PHE D 346 1 6
HELIX 29 AD2 PRO D 382 ALA D 384 5 3
HELIX 30 AD3 ASN D 392 VAL D 403 1 12
HELIX 31 AD4 ASP D 583 LYS D 587 5 5
HELIX 32 AD5 TYR D 661 GLY D 671 1 11
HELIX 33 AD6 GLY D 686 GLY D 691 1 6
HELIX 34 AD7 ALA D 692 LYS D 694 5 3
HELIX 35 AD8 VAL D 700 TYR D 716 1 17
HELIX 36 AD9 SER D 730 LYS D 743 1 14
HELIX 37 AE1 VAL D 758 TYR D 762 5 5
HELIX 38 AE2 ASP D 763 ASP D 772 1 10
HELIX 39 AE3 ASN D 777 SER D 785 1 9
HELIX 40 AE4 VAL D 786 LEU D 793 5 8
HELIX 41 AE5 HIS D 812 GLY D 827 1 16
HELIX 42 AE6 CYS D 844 LEU D 863 1 20
SHEET 1 AA1 4 HIS A 54 GLN A 60 0
SHEET 2 AA1 4 HIS A 68 GLY A 76 -1 O LEU A 75 N HIS A 54
SHEET 3 AA1 4 SER A 85 PRO A 92 -1 O LEU A 87 N TYR A 74
SHEET 4 AA1 4 LYS A 106 GLN A 107 -1 O LYS A 106 N TYR A 88
SHEET 1 AA2 2 ALA A 99 LEU A 103 0
SHEET 2 AA2 2 GLY B 275 GLU B 279 -1 O MET B 276 N LEU A 102
SHEET 1 AA3 4 TYR A 142 HIS A 145 0
SHEET 2 AA3 4 LEU A 150 ALA A 155 -1 O LEU A 152 N ASP A 143
SHEET 3 AA3 4 SER A 158 ARG A 163 -1 O SER A 158 N ALA A 155
SHEET 4 AA3 4 LEU A 178 ILE A 180 -1 O ILE A 180 N LEU A 159
SHEET 1 AA4 4 ARG A 188 ILE A 193 0
SHEET 2 AA4 4 PHE A 200 ASN A 205 -1 O ILE A 204 N MET A 189
SHEET 3 AA4 4 ASP A 208 ASN A 213 -1 O TRP A 210 N PHE A 203
SHEET 4 AA4 4 GLU A 219 ARG A 221 -1 O ARG A 220 N VAL A 211
SHEET 1 AA5 3 LYS A 237 ALA A 239 0
SHEET 2 AA5 3 LYS A 271 ASP A 281 -1 O VAL A 280 N SER A 238
SHEET 3 AA5 3 SER A 263 TRP A 264 -1 N SER A 263 O THR A 272
SHEET 1 AA6 5 TYR A 256 TRP A 258 0
SHEET 2 AA6 5 LYS A 271 ASP A 281 -1 O LEU A 276 N TRP A 257
SHEET 3 AA6 5 LYS A 314 THR A 324 -1 O ALA A 320 N ILE A 275
SHEET 4 AA6 5 ILE A 330 LEU A 338 -1 O GLN A 334 N GLU A 321
SHEET 5 AA6 5 PHE A 386 PRO A 388 -1 O ILE A 387 N GLU A 337
SHEET 1 AA7 2 VAL A 287 PRO A 291 0
SHEET 2 AA7 2 THR A 300 ARG A 304 -1 O ASP A 301 N VAL A 290
SHEET 1 AA8 4 TYR A 351 TRP A 357 0
SHEET 2 AA8 4 ALA A 364 LEU A 369 -1 O TRP A 365 N GLY A 356
SHEET 3 AA8 4 TRP A 375 LEU A 381 -1 O GLN A 377 N PHE A 368
SHEET 4 AA8 4 TYR A 410 VAL A 416 -1 O GLU A 415 N LEU A 376
SHEET 1 AA9 3 LEU A 439 ASN A 445 0
SHEET 2 AA9 3 HIS A 453 ALA A 459 -1 O VAL A 457 N PHE A 441
SHEET 3 AA9 3 ILE A 483 ALA A 488 -1 O LYS A 484 N THR A 458
SHEET 1 AB1 4 TRP A 505 ASN A 507 0
SHEET 2 AB1 4 LEU A 512 GLY A 517 -1 O TYR A 514 N TRP A 505
SHEET 3 AB1 4 HIS A 526 SER A 531 -1 O TYR A 528 N PHE A 515
SHEET 4 AB1 4 VAL A 539 ARG A 540 -1 O VAL A 539 N VAL A 529
SHEET 1 AB2 4 SER A 547 MET A 552 0
SHEET 2 AB2 4 MET A 558 SER A 564 -1 O SER A 564 N SER A 547
SHEET 3 AB2 4 CYS A 571 SER A 578 -1 O HIS A 573 N SER A 561
SHEET 4 AB2 4 GLN A 588 MET A 596 -1 O MET A 595 N VAL A 572
SHEET 1 AB3 8 GLU A 609 HIS A 614 0
SHEET 2 AB3 8 ARG A 620 TYR A 626 -1 O LEU A 621 N PHE A 613
SHEET 3 AB3 8 ALA A 673 ASP A 678 -1 O ASP A 678 N TYR A 622
SHEET 4 AB3 8 HIS A 637 PHE A 642 1 N VAL A 640 O ALA A 673
SHEET 5 AB3 8 ILE A 719 TRP A 729 1 O ALA A 725 N LEU A 641
SHEET 6 AB3 8 VAL A 749 GLY A 753 1 O GLY A 753 N GLY A 728
SHEET 7 AB3 8 LEU A 800 GLY A 805 1 O LEU A 803 N ALA A 752
SHEET 8 AB3 8 GLN A 831 TYR A 835 1 O GLN A 831 N ILE A 802
SHEET 1 AB4 3 GLU B 171 ASP B 174 0
SHEET 2 AB4 3 ARG B 179 PHE B 184 -1 O ARG B 179 N ILE B 173
SHEET 3 AB4 3 VAL B 205 ILE B 209 -1 O ILE B 209 N TYR B 180
SHEET 1 AB5 4 LEU B 191 TRP B 192 0
SHEET 2 AB5 4 LEU B 197 VAL B 201 -1 O LEU B 197 N TRP B 192
SHEET 3 AB5 4 VAL B 245 PRO B 251 -1 O HIS B 249 N GLY B 198
SHEET 4 AB5 4 TYR B 288 GLU B 292 -1 O ALA B 289 N LEU B 250
SHEET 1 AB6 2 PHE B 211 GLY B 212 0
SHEET 2 AB6 2 LEU B 234 PHE B 235 -1 O LEU B 234 N GLY B 212
SHEET 1 AB7 2 PHE B 266 LEU B 267 0
SHEET 2 AB7 2 LEU B 311 SER B 312 -1 O LEU B 311 N LEU B 267
SHEET 1 AB8 2 HIS B 326 LEU B 334 0
SHEET 2 AB8 2 VAL B 337 LYS B 345 -1 O LYS B 345 N HIS B 326
SHEET 1 AB9 4 PRO B 396 GLU B 398 0
SHEET 2 AB9 4 ASN B 381 PRO B 386 -1 N LEU B 382 O GLY B 397
SHEET 3 AB9 4 LYS B 421 TRP B 428 -1 O VAL B 427 N LYS B 383
SHEET 4 AB9 4 PRO B 434 ALA B 441 -1 O VAL B 435 N LEU B 426
SHEET 1 AC1 2 TYR C 322 TYR C 323 0
SHEET 2 AC1 2 VAL C 376 SER C 377 -1 O VAL C 376 N TYR C 323
SHEET 1 AC2 2 PRO C 327 ASP C 329 0
SHEET 2 AC2 2 LEU C 342 THR C 344 -1 O LEU C 343 N GLU C 328
SHEET 1 AC3 4 PRO C 396 GLY C 397 0
SHEET 2 AC3 4 LEU C 382 PRO C 386 -1 N LEU C 382 O GLY C 397
SHEET 3 AC3 4 LYS C 421 TRP C 428 -1 O THR C 425 N MET C 385
SHEET 4 AC3 4 PRO C 434 ALA C 441 -1 O GLN C 438 N GLY C 424
SHEET 1 AC4 4 HIS D 54 GLN D 60 0
SHEET 2 AC4 4 HIS D 68 LEU D 75 -1 O TYR D 73 N GLN D 57
SHEET 3 AC4 4 LEU D 87 PRO D 92 -1 O LEU D 87 N TYR D 74
SHEET 4 AC4 4 LYS D 106 GLN D 107 -1 O LYS D 106 N TYR D 88
SHEET 1 AC5 4 TYR D 142 HIS D 145 0
SHEET 2 AC5 4 LEU D 150 GLN D 154 -1 O LEU D 152 N ASP D 143
SHEET 3 AC5 4 LEU D 159 HIS D 161 -1 O PHE D 160 N PHE D 153
SHEET 4 AC5 4 LEU D 178 ILE D 180 -1 O ILE D 180 N LEU D 159
SHEET 1 AC6 4 MET D 189 ILE D 193 0
SHEET 2 AC6 4 PHE D 200 ASN D 205 -1 O ILE D 204 N MET D 189
SHEET 3 AC6 4 ASP D 208 ASN D 213 -1 O TRP D 210 N PHE D 203
SHEET 4 AC6 4 GLU D 219 ARG D 221 -1 O ARG D 220 N VAL D 211
SHEET 1 AC7 5 LYS D 237 ALA D 239 0
SHEET 2 AC7 5 ILE D 275 ASP D 281 -1 O VAL D 280 N SER D 238
SHEET 3 AC7 5 LYS D 314 THR D 324 -1 O LYS D 318 N TYR D 277
SHEET 4 AC7 5 LYS D 271 LEU D 273 -1 N LYS D 271 O THR D 324
SHEET 5 AC7 5 SER D 263 TRP D 264 -1 N SER D 263 O THR D 272
SHEET 1 AC8 5 TYR D 256 TRP D 258 0
SHEET 2 AC8 5 ILE D 275 ASP D 281 -1 O LEU D 276 N TRP D 257
SHEET 3 AC8 5 LYS D 314 THR D 324 -1 O LYS D 318 N TYR D 277
SHEET 4 AC8 5 ILE D 330 LEU D 338 -1 O GLN D 334 N GLU D 321
SHEET 5 AC8 5 PHE D 386 PRO D 388 -1 O ILE D 387 N GLU D 337
SHEET 1 AC9 2 VAL D 287 PRO D 291 0
SHEET 2 AC9 2 THR D 300 ARG D 304 -1 O ASP D 301 N VAL D 290
SHEET 1 AD1 4 TYR D 351 ALA D 355 0
SHEET 2 AD1 4 ALA D 364 LEU D 369 -1 O MET D 367 N ARG D 354
SHEET 3 AD1 4 TRP D 375 LEU D 381 -1 O GLN D 377 N PHE D 368
SHEET 4 AD1 4 TYR D 410 VAL D 416 -1 O TYR D 413 N LEU D 378
SHEET 1 AD2 3 CYS D 440 ASN D 445 0
SHEET 2 AD2 3 HIS D 453 ALA D 459 -1 O VAL D 457 N PHE D 441
SHEET 3 AD2 3 ILE D 483 ALA D 488 -1 O LYS D 484 N THR D 458
SHEET 1 AD3 4 TRP D 505 ASN D 507 0
SHEET 2 AD3 4 LEU D 512 GLY D 517 -1 O TYR D 514 N TRP D 505
SHEET 3 AD3 4 HIS D 526 SER D 531 -1 O TYR D 528 N PHE D 515
SHEET 4 AD3 4 VAL D 539 ARG D 540 -1 O VAL D 539 N VAL D 529
SHEET 1 AD4 4 SER D 547 MET D 552 0
SHEET 2 AD4 4 MET D 558 SER D 564 -1 O HIS D 562 N SER D 549
SHEET 3 AD4 4 CYS D 571 SER D 578 -1 O CYS D 571 N TYR D 563
SHEET 4 AD4 4 GLN D 588 MET D 596 -1 O MET D 596 N VAL D 572
SHEET 1 AD5 8 GLU D 609 HIS D 614 0
SHEET 2 AD5 8 ARG D 620 TYR D 626 -1 O GLY D 623 N PHE D 611
SHEET 3 AD5 8 ALA D 673 ASP D 678 -1 O ASP D 678 N TYR D 622
SHEET 4 AD5 8 HIS D 637 PHE D 642 1 N VAL D 640 O ALA D 673
SHEET 5 AD5 8 ILE D 719 TRP D 729 1 O ALA D 725 N LEU D 641
SHEET 6 AD5 8 VAL D 749 GLY D 753 1 O ILE D 751 N ILE D 726
SHEET 7 AD5 8 LEU D 800 GLY D 805 1 O LEU D 803 N ALA D 752
SHEET 8 AD5 8 GLN D 831 TYR D 835 1 O GLN D 831 N ILE D 802
LINK OG SER A 730 B15 GK2 A 901 1555 1555 1.43
LINK OG SER D 730 B15 GK2 D 901 1555 1555 1.43
CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1
ORIGX1 1.000000 0.000000 0.000000 0.00000
ORIGX2 0.000000 1.000000 0.000000 0.00000
ORIGX3 0.000000 0.000000 1.000000 0.00000
SCALE1 1.000000 0.000000 0.000000 0.00000
SCALE2 0.000000 1.000000 0.000000 0.00000
SCALE3 0.000000 0.000000 1.000000 0.00000
TER 6817 LEU A 863
TER 8971 PRO B 445
TER 9995 PRO C 446
TER 16429 LEU D 863
MASTER 1055 0 2 42 119 0 0 616455 4 32 222
END |