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HEADER BIOSYNTHETIC PROTEIN/IMMUNE SYSTEM 28-MAR-21 7M7G
TITLE 6-DEOXYERYTHRONOLIDE B SYNTHASE (DEBS) MODULE 1 IN COMPLEX WITH
TITLE 2 ANTIBODY FRAGMENT 1B2: STATE 2
COMPND MOL_ID: 1;
COMPND 2 MOLECULE: ERYAI,6-DEOXYERYTHRONOLIDE-B SYNTHASE ERYA3, MODULES 5 AND
COMPND 3 6 CHIMERA;
COMPND 4 CHAIN: A, B;
COMPND 5 FRAGMENT: ERYA1 (UNP RESIDUES 225-2010) + ERYA3 (UNP RESIDUES 2896-
COMPND 6 3172);
COMPND 7 SYNONYM: DEBS (3)M1TE;
COMPND 8 EC: 2.3.1.94;
COMPND 9 ENGINEERED: YES;
COMPND 10 MOL_ID: 2;
COMPND 11 MOLECULE: 1B2 (HEAVY CHAIN);
COMPND 12 CHAIN: C, E;
COMPND 13 ENGINEERED: YES;
COMPND 14 MOL_ID: 3;
COMPND 15 MOLECULE: 1B2 (LIGHT CHAIN);
COMPND 16 CHAIN: D, F;
COMPND 17 ENGINEERED: YES
SOURCE MOL_ID: 1;
SOURCE 2 ORGANISM_SCIENTIFIC: SACCHAROPOLYSPORA ERYTHRAEA;
SOURCE 3 ORGANISM_COMMON: STREPTOMYCES ERYTHRAEUS;
SOURCE 4 ORGANISM_TAXID: 1836;
SOURCE 5 GENE: ERYAI, ERYA;
SOURCE 6 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3);
SOURCE 7 EXPRESSION_SYSTEM_TAXID: 469008;
SOURCE 8 MOL_ID: 2;
SOURCE 9 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 10 ORGANISM_COMMON: HUMAN;
SOURCE 11 ORGANISM_TAXID: 9606;
SOURCE 12 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3);
SOURCE 13 EXPRESSION_SYSTEM_TAXID: 469008;
SOURCE 14 MOL_ID: 3;
SOURCE 15 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 16 ORGANISM_COMMON: HUMAN;
SOURCE 17 ORGANISM_TAXID: 9606;
SOURCE 18 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3);
SOURCE 19 EXPRESSION_SYSTEM_TAXID: 469008
KEYWDS POLYKETIDE SYNTHASE, ANTIBODY FRAGMENT, BIOSYNTHETIC PROTEIN-IMMUNE
KEYWDS 2 SYSTEM COMPLEX
EXPDTA ELECTRON MICROSCOPY
AUTHOR D.P.COGAN,K.ZHANG,W.CHIU,C.KHOSLA
REVDAT 1 17-NOV-21 7M7G 0
JRNL AUTH D.P.COGAN,K.ZHANG,X.LI,S.LI,G.D.PINTILIE,S.H.ROH,C.S.CRAIK,
JRNL AUTH 2 W.CHIU,C.KHOSLA
JRNL TITL MAPPING THE CATALYTIC CONFORMATIONS OF AN ASSEMBLY-LINE
JRNL TITL 2 POLYKETIDE SYNTHASE MODULE.
JRNL REF SCIENCE V. 374 729 2021
JRNL REFN ESSN 1095-9203
JRNL PMID 34735239
JRNL DOI 10.1126/SCIENCE.ABI8358
REMARK 2
REMARK 2 RESOLUTION. 4.10 ANGSTROMS.
REMARK 3
REMARK 3 REFINEMENT.
REMARK 3 SOFTWARE PACKAGES : EMAN2, EPU, CRYOSPARC
REMARK 3 RECONSTRUCTION SCHEMA : NULL
REMARK 3
REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT
REMARK 3 PDB ENTRY : NULL
REMARK 3 REFINEMENT SPACE : NULL
REMARK 3 REFINEMENT PROTOCOL : NULL
REMARK 3 REFINEMENT TARGET : NULL
REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL
REMARK 3
REMARK 3 FITTING PROCEDURE : NULL
REMARK 3
REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS
REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 4.100
REMARK 3 NUMBER OF PARTICLES : 56378
REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE
REMARK 3 CORRECTION
REMARK 3
REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL
REMARK 3
REMARK 3 OTHER DETAILS: NULL
REMARK 4
REMARK 4 7M7G COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 29-MAR-21.
REMARK 100 THE DEPOSITION ID IS D_1000255620.
REMARK 245
REMARK 245 EXPERIMENTAL DETAILS
REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE
REMARK 245 SPECIMEN TYPE : NULL
REMARK 245
REMARK 245 ELECTRON MICROSCOPE SAMPLE
REMARK 245 SAMPLE TYPE : PARTICLE
REMARK 245 PARTICLE TYPE : POINT
REMARK 245 NAME OF SAMPLE : COMPLEX BETWEEN DEBS (3)M1TE
REMARK 245 AND ANTIBODY FRAGMENT 1B2
REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 10.00
REMARK 245 SAMPLE SUPPORT DETAILS : NULL
REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL
REMARK 245 SAMPLE BUFFER : NULL
REMARK 245 PH : 7.20
REMARK 245 SAMPLE DETAILS : NULL
REMARK 245
REMARK 245 DATA ACQUISITION
REMARK 245 DATE OF EXPERIMENT : NULL
REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : 10234
REMARK 245 TEMPERATURE (KELVIN) : NULL
REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS
REMARK 245 DETECTOR TYPE : FEI FALCON IV (4K X 4K)
REMARK 245 MINIMUM DEFOCUS (NM) : NULL
REMARK 245 MAXIMUM DEFOCUS (NM) : NULL
REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 NOMINAL CS : NULL
REMARK 245 IMAGING MODE : BRIGHT FIELD
REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 5000.00
REMARK 245 ILLUMINATION MODE : OTHER
REMARK 245 NOMINAL MAGNIFICATION : NULL
REMARK 245 CALIBRATED MAGNIFICATION : NULL
REMARK 245 SOURCE : FIELD EMISSION GUN
REMARK 245 ACCELERATION VOLTAGE (KV) : 300
REMARK 245 IMAGING DETAILS : NULL
REMARK 247
REMARK 247 ELECTRON MICROSCOPY
REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON
REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE
REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES
REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION
REMARK 247 OF THE STRUCTURE FACTORS.
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: HEXAMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465 M RES C SSSEQI
REMARK 465 GLY A 667
REMARK 465 ALA A 668
REMARK 465 LEU A 669
REMARK 465 SER A 670
REMARK 465 LEU A 671
REMARK 465 ASP A 672
REMARK 465 ASP A 673
REMARK 465 ALA A 674
REMARK 465 HIS A 768
REMARK 465 ALA A 769
REMARK 465 GLU A 770
REMARK 465 LEU A 771
REMARK 465 GLY A 772
REMARK 465 GLU A 773
REMARK 465 ASP A 774
REMARK 465 PHE A 775
REMARK 465 HIS A 776
REMARK 465 PRO A 777
REMARK 465 LEU A 778
REMARK 465 PRO A 779
REMARK 465 GLY A 780
REMARK 465 PHE A 781
REMARK 465 VAL A 782
REMARK 465 PRO A 783
REMARK 465 VAL A 1126
REMARK 465 ARG A 1127
REMARK 465 ALA A 1128
REMARK 465 ALA A 1129
REMARK 465 ALA A 1130
REMARK 465 PRO A 1131
REMARK 465 ALA A 1132
REMARK 465 THR A 1133
REMARK 465 ASP A 1134
REMARK 465 ASP A 1135
REMARK 465 ALA A 1391
REMARK 465 ALA A 1392
REMARK 465 PRO A 1393
REMARK 465 GLN A 1394
REMARK 465 ALA A 1395
REMARK 465 ALA A 1396
REMARK 465 ALA A 1397
REMARK 465 GLU A 1398
REMARK 465 PRO A 1399
REMARK 465 ARG A 1400
REMARK 465 VAL A 1401
REMARK 465 GLY A 1402
REMARK 465 ALA A 1403
REMARK 465 LEU A 1404
REMARK 465 ALA A 1405
REMARK 465 SER A 1406
REMARK 465 LEU A 1407
REMARK 465 PRO A 1408
REMARK 465 ALA A 1409
REMARK 465 PRO A 1410
REMARK 465 GLU A 1411
REMARK 465 ARG A 1412
REMARK 465 GLU A 1413
REMARK 465 LYS A 1414
REMARK 465 ALA A 1415
REMARK 465 LEU A 1416
REMARK 465 PHE A 1417
REMARK 465 GLU A 1418
REMARK 465 LEU A 1419
REMARK 465 VAL A 1420
REMARK 465 ARG A 1421
REMARK 465 SER A 1422
REMARK 465 HIS A 1423
REMARK 465 ALA A 1424
REMARK 465 ALA A 1425
REMARK 465 ALA A 1426
REMARK 465 VAL A 1427
REMARK 465 LEU A 1428
REMARK 465 GLY A 1429
REMARK 465 HIS A 1430
REMARK 465 ALA A 1431
REMARK 465 SER A 1432
REMARK 465 ALA A 1433
REMARK 465 GLU A 1434
REMARK 465 ARG A 1435
REMARK 465 VAL A 1436
REMARK 465 PRO A 1437
REMARK 465 ALA A 1438
REMARK 465 ASP A 1439
REMARK 465 GLN A 1440
REMARK 465 ALA A 1441
REMARK 465 PHE A 1442
REMARK 465 ALA A 1443
REMARK 465 GLU A 1444
REMARK 465 LEU A 1445
REMARK 465 GLY A 1446
REMARK 465 VAL A 1447
REMARK 465 ASP A 1448
REMARK 465 SER A 1449
REMARK 465 LEU A 1450
REMARK 465 SER A 1451
REMARK 465 ALA A 1452
REMARK 465 LEU A 1453
REMARK 465 GLU A 1454
REMARK 465 LEU A 1455
REMARK 465 ARG A 1456
REMARK 465 ASN A 1457
REMARK 465 ARG A 1458
REMARK 465 LEU A 1459
REMARK 465 GLY A 1460
REMARK 465 ALA A 1461
REMARK 465 ALA A 1462
REMARK 465 THR A 1463
REMARK 465 GLY A 1464
REMARK 465 VAL A 1465
REMARK 465 ARG A 1466
REMARK 465 LEU A 1467
REMARK 465 PRO A 1468
REMARK 465 THR A 1469
REMARK 465 THR A 1470
REMARK 465 THR A 1471
REMARK 465 VAL A 1472
REMARK 465 PHE A 1473
REMARK 465 ASP A 1474
REMARK 465 HIS A 1475
REMARK 465 PRO A 1476
REMARK 465 ASP A 1477
REMARK 465 VAL A 1478
REMARK 465 ARG A 1479
REMARK 465 THR A 1480
REMARK 465 LEU A 1481
REMARK 465 ALA A 1482
REMARK 465 ALA A 1483
REMARK 465 HIS A 1484
REMARK 465 LEU A 1485
REMARK 465 THR A 1486
REMARK 465 SER A 1487
REMARK 465 GLU A 1488
REMARK 465 LEU A 1489
REMARK 465 GLY A 1490
REMARK 465 SER A 1491
REMARK 465 GLY A 1492
REMARK 465 THR A 1493
REMARK 465 PRO A 1494
REMARK 465 ALA A 1495
REMARK 465 ARG A 1496
REMARK 465 GLU A 1497
REMARK 465 ALA A 1498
REMARK 465 SER A 1499
REMARK 465 SER A 1500
REMARK 465 ALA A 1501
REMARK 465 LEU A 1502
REMARK 465 ARG A 1503
REMARK 465 ASP A 1504
REMARK 465 GLY A 1505
REMARK 465 TYR A 1506
REMARK 465 ARG A 1507
REMARK 465 GLN A 1508
REMARK 465 ALA A 1509
REMARK 465 GLY A 1510
REMARK 465 VAL A 1511
REMARK 465 SER A 1512
REMARK 465 GLY A 1513
REMARK 465 ARG A 1514
REMARK 465 VAL A 1515
REMARK 465 ARG A 1516
REMARK 465 SER A 1517
REMARK 465 TYR A 1518
REMARK 465 LEU A 1519
REMARK 465 ASP A 1520
REMARK 465 LEU A 1521
REMARK 465 LEU A 1522
REMARK 465 ALA A 1523
REMARK 465 GLY A 1524
REMARK 465 LEU A 1525
REMARK 465 SER A 1526
REMARK 465 ASP A 1527
REMARK 465 PHE A 1528
REMARK 465 ARG A 1529
REMARK 465 GLU A 1530
REMARK 465 HIS A 1531
REMARK 465 PHE A 1532
REMARK 465 ASP A 1533
REMARK 465 GLY A 1534
REMARK 465 SER A 1535
REMARK 465 ASP A 1536
REMARK 465 GLY A 1537
REMARK 465 PHE A 1538
REMARK 465 SER A 1539
REMARK 465 LEU A 1540
REMARK 465 ASP A 1541
REMARK 465 LEU A 1542
REMARK 465 VAL A 1543
REMARK 465 ASP A 1544
REMARK 465 MET A 1545
REMARK 465 ALA A 1546
REMARK 465 ASP A 1547
REMARK 465 GLY A 1548
REMARK 465 PRO A 1549
REMARK 465 GLY A 1550
REMARK 465 GLU A 1551
REMARK 465 VAL A 1552
REMARK 465 THR A 1553
REMARK 465 VAL A 1554
REMARK 465 ILE A 1555
REMARK 465 CYS A 1556
REMARK 465 CYS A 1557
REMARK 465 ALA A 1558
REMARK 465 GLY A 1559
REMARK 465 THR A 1560
REMARK 465 ALA A 1561
REMARK 465 ALA A 1562
REMARK 465 ILE A 1563
REMARK 465 SER A 1564
REMARK 465 GLY A 1565
REMARK 465 PRO A 1566
REMARK 465 HIS A 1567
REMARK 465 GLU A 1568
REMARK 465 PHE A 1569
REMARK 465 THR A 1570
REMARK 465 ARG A 1571
REMARK 465 LEU A 1572
REMARK 465 ALA A 1573
REMARK 465 GLY A 1574
REMARK 465 ALA A 1575
REMARK 465 LEU A 1576
REMARK 465 ARG A 1577
REMARK 465 GLY A 1578
REMARK 465 ILE A 1579
REMARK 465 ALA A 1580
REMARK 465 PRO A 1581
REMARK 465 VAL A 1582
REMARK 465 ARG A 1583
REMARK 465 ALA A 1584
REMARK 465 VAL A 1585
REMARK 465 PRO A 1586
REMARK 465 GLN A 1587
REMARK 465 PRO A 1588
REMARK 465 GLY A 1589
REMARK 465 TYR A 1590
REMARK 465 GLU A 1591
REMARK 465 GLU A 1592
REMARK 465 GLY A 1593
REMARK 465 GLU A 1594
REMARK 465 PRO A 1595
REMARK 465 LEU A 1596
REMARK 465 PRO A 1597
REMARK 465 SER A 1598
REMARK 465 SER A 1599
REMARK 465 MET A 1600
REMARK 465 ALA A 1601
REMARK 465 ALA A 1602
REMARK 465 VAL A 1603
REMARK 465 ALA A 1604
REMARK 465 ALA A 1605
REMARK 465 VAL A 1606
REMARK 465 GLN A 1607
REMARK 465 ALA A 1608
REMARK 465 ASP A 1609
REMARK 465 ALA A 1610
REMARK 465 VAL A 1611
REMARK 465 ILE A 1612
REMARK 465 ARG A 1613
REMARK 465 THR A 1614
REMARK 465 GLN A 1615
REMARK 465 GLY A 1616
REMARK 465 ASP A 1617
REMARK 465 LYS A 1618
REMARK 465 PRO A 1619
REMARK 465 PHE A 1620
REMARK 465 VAL A 1621
REMARK 465 VAL A 1622
REMARK 465 ALA A 1623
REMARK 465 GLY A 1624
REMARK 465 HIS A 1625
REMARK 465 SER A 1626
REMARK 465 ALA A 1627
REMARK 465 GLY A 1628
REMARK 465 ALA A 1629
REMARK 465 LEU A 1630
REMARK 465 MET A 1631
REMARK 465 ALA A 1632
REMARK 465 TYR A 1633
REMARK 465 ALA A 1634
REMARK 465 LEU A 1635
REMARK 465 ALA A 1636
REMARK 465 THR A 1637
REMARK 465 GLU A 1638
REMARK 465 LEU A 1639
REMARK 465 LEU A 1640
REMARK 465 ASP A 1641
REMARK 465 ARG A 1642
REMARK 465 GLY A 1643
REMARK 465 HIS A 1644
REMARK 465 PRO A 1645
REMARK 465 PRO A 1646
REMARK 465 ARG A 1647
REMARK 465 GLY A 1648
REMARK 465 VAL A 1649
REMARK 465 VAL A 1650
REMARK 465 LEU A 1651
REMARK 465 ILE A 1652
REMARK 465 ASP A 1653
REMARK 465 VAL A 1654
REMARK 465 TYR A 1655
REMARK 465 PRO A 1656
REMARK 465 PRO A 1657
REMARK 465 GLY A 1658
REMARK 465 HIS A 1659
REMARK 465 GLN A 1660
REMARK 465 ASP A 1661
REMARK 465 ALA A 1662
REMARK 465 MET A 1663
REMARK 465 ASN A 1664
REMARK 465 ALA A 1665
REMARK 465 TRP A 1666
REMARK 465 LEU A 1667
REMARK 465 GLU A 1668
REMARK 465 GLU A 1669
REMARK 465 LEU A 1670
REMARK 465 THR A 1671
REMARK 465 ALA A 1672
REMARK 465 THR A 1673
REMARK 465 LEU A 1674
REMARK 465 PHE A 1675
REMARK 465 ASP A 1676
REMARK 465 ARG A 1677
REMARK 465 GLU A 1678
REMARK 465 THR A 1679
REMARK 465 VAL A 1680
REMARK 465 ARG A 1681
REMARK 465 MET A 1682
REMARK 465 ASP A 1683
REMARK 465 ASP A 1684
REMARK 465 THR A 1685
REMARK 465 ARG A 1686
REMARK 465 LEU A 1687
REMARK 465 THR A 1688
REMARK 465 ALA A 1689
REMARK 465 LEU A 1690
REMARK 465 GLY A 1691
REMARK 465 ALA A 1692
REMARK 465 TYR A 1693
REMARK 465 ASP A 1694
REMARK 465 ARG A 1695
REMARK 465 LEU A 1696
REMARK 465 THR A 1697
REMARK 465 GLY A 1698
REMARK 465 GLN A 1699
REMARK 465 TRP A 1700
REMARK 465 ARG A 1701
REMARK 465 PRO A 1702
REMARK 465 ARG A 1703
REMARK 465 GLU A 1704
REMARK 465 THR A 1705
REMARK 465 GLY A 1706
REMARK 465 LEU A 1707
REMARK 465 PRO A 1708
REMARK 465 THR A 1709
REMARK 465 LEU A 1710
REMARK 465 LEU A 1711
REMARK 465 VAL A 1712
REMARK 465 SER A 1713
REMARK 465 ALA A 1714
REMARK 465 GLY A 1715
REMARK 465 GLU A 1716
REMARK 465 PRO A 1717
REMARK 465 MET A 1718
REMARK 465 GLY A 1719
REMARK 465 PRO A 1720
REMARK 465 TRP A 1721
REMARK 465 PRO A 1722
REMARK 465 ASP A 1723
REMARK 465 ASP A 1724
REMARK 465 SER A 1725
REMARK 465 TRP A 1726
REMARK 465 LYS A 1727
REMARK 465 PRO A 1728
REMARK 465 THR A 1729
REMARK 465 TRP A 1730
REMARK 465 PRO A 1731
REMARK 465 PHE A 1732
REMARK 465 GLU A 1733
REMARK 465 HIS A 1734
REMARK 465 ASP A 1735
REMARK 465 THR A 1736
REMARK 465 VAL A 1737
REMARK 465 ALA A 1738
REMARK 465 VAL A 1739
REMARK 465 PRO A 1740
REMARK 465 GLY A 1741
REMARK 465 ASP A 1742
REMARK 465 HIS A 1743
REMARK 465 PHE A 1744
REMARK 465 THR A 1745
REMARK 465 MET A 1746
REMARK 465 VAL A 1747
REMARK 465 GLN A 1748
REMARK 465 GLU A 1749
REMARK 465 HIS A 1750
REMARK 465 ALA A 1751
REMARK 465 ASP A 1752
REMARK 465 ALA A 1753
REMARK 465 ILE A 1754
REMARK 465 ALA A 1755
REMARK 465 ARG A 1756
REMARK 465 HIS A 1757
REMARK 465 ILE A 1758
REMARK 465 ASP A 1759
REMARK 465 ALA A 1760
REMARK 465 TRP A 1761
REMARK 465 LEU A 1762
REMARK 465 GLY A 1763
REMARK 465 GLY A 1764
REMARK 465 GLY A 1765
REMARK 465 ASN A 1766
REMARK 465 SER A 1767
REMARK 465 SER A 1768
REMARK 465 SER A 1769
REMARK 465 VAL A 1770
REMARK 465 ASP A 1771
REMARK 465 LYS A 1772
REMARK 465 LEU A 1773
REMARK 465 ALA A 1774
REMARK 465 ALA A 1775
REMARK 465 ALA A 1776
REMARK 465 LEU A 1777
REMARK 465 GLU A 1778
REMARK 465 HIS A 1779
REMARK 465 HIS A 1780
REMARK 465 HIS A 1781
REMARK 465 HIS A 1782
REMARK 465 HIS A 1783
REMARK 465 HIS A 1784
REMARK 465 VAL B 1126
REMARK 465 ARG B 1127
REMARK 465 ALA B 1128
REMARK 465 ALA B 1129
REMARK 465 ALA B 1130
REMARK 465 PRO B 1131
REMARK 465 ALA B 1132
REMARK 465 THR B 1133
REMARK 465 ASP B 1134
REMARK 465 ASP B 1135
REMARK 465 GLU B 1136
REMARK 465 ALA B 1391
REMARK 465 ALA B 1392
REMARK 465 PRO B 1393
REMARK 465 GLN B 1394
REMARK 465 ALA B 1395
REMARK 465 ALA B 1396
REMARK 465 ALA B 1397
REMARK 465 GLU B 1398
REMARK 465 PRO B 1399
REMARK 465 ARG B 1400
REMARK 465 VAL B 1401
REMARK 465 GLY B 1402
REMARK 465 ALA B 1403
REMARK 465 LEU B 1404
REMARK 465 ALA B 1405
REMARK 465 SER B 1406
REMARK 465 LEU B 1407
REMARK 465 PRO B 1408
REMARK 465 ALA B 1409
REMARK 465 PRO B 1410
REMARK 465 GLU B 1411
REMARK 465 ARG B 1412
REMARK 465 GLU B 1413
REMARK 465 LYS B 1414
REMARK 465 ALA B 1415
REMARK 465 LEU B 1416
REMARK 465 PHE B 1417
REMARK 465 GLU B 1418
REMARK 465 LEU B 1419
REMARK 465 VAL B 1420
REMARK 465 ARG B 1421
REMARK 465 SER B 1422
REMARK 465 HIS B 1423
REMARK 465 ALA B 1424
REMARK 465 ALA B 1425
REMARK 465 ALA B 1426
REMARK 465 VAL B 1427
REMARK 465 LEU B 1428
REMARK 465 GLY B 1429
REMARK 465 HIS B 1430
REMARK 465 ALA B 1431
REMARK 465 SER B 1432
REMARK 465 ALA B 1433
REMARK 465 GLU B 1434
REMARK 465 ARG B 1435
REMARK 465 VAL B 1436
REMARK 465 PRO B 1437
REMARK 465 ALA B 1438
REMARK 465 ASP B 1439
REMARK 465 GLN B 1440
REMARK 465 ALA B 1441
REMARK 465 PHE B 1442
REMARK 465 ALA B 1443
REMARK 465 GLU B 1444
REMARK 465 LEU B 1445
REMARK 465 GLY B 1446
REMARK 465 VAL B 1447
REMARK 465 ASP B 1448
REMARK 465 SER B 1449
REMARK 465 LEU B 1450
REMARK 465 SER B 1451
REMARK 465 ALA B 1452
REMARK 465 LEU B 1453
REMARK 465 GLU B 1454
REMARK 465 LEU B 1455
REMARK 465 ARG B 1456
REMARK 465 ASN B 1457
REMARK 465 ARG B 1458
REMARK 465 LEU B 1459
REMARK 465 GLY B 1460
REMARK 465 ALA B 1461
REMARK 465 ALA B 1462
REMARK 465 THR B 1463
REMARK 465 GLY B 1464
REMARK 465 VAL B 1465
REMARK 465 ARG B 1466
REMARK 465 LEU B 1467
REMARK 465 PRO B 1468
REMARK 465 THR B 1469
REMARK 465 THR B 1470
REMARK 465 THR B 1471
REMARK 465 VAL B 1472
REMARK 465 PHE B 1473
REMARK 465 ASP B 1474
REMARK 465 HIS B 1475
REMARK 465 PRO B 1476
REMARK 465 ASP B 1477
REMARK 465 VAL B 1478
REMARK 465 ARG B 1479
REMARK 465 THR B 1480
REMARK 465 LEU B 1481
REMARK 465 ALA B 1482
REMARK 465 ALA B 1483
REMARK 465 HIS B 1484
REMARK 465 LEU B 1485
REMARK 465 THR B 1486
REMARK 465 SER B 1487
REMARK 465 GLU B 1488
REMARK 465 LEU B 1489
REMARK 465 GLY B 1490
REMARK 465 SER B 1491
REMARK 465 GLY B 1492
REMARK 465 THR B 1493
REMARK 465 PRO B 1494
REMARK 465 ALA B 1495
REMARK 465 ARG B 1496
REMARK 465 GLU B 1497
REMARK 465 ALA B 1498
REMARK 465 SER B 1499
REMARK 465 SER B 1500
REMARK 465 ALA B 1501
REMARK 465 LEU B 1502
REMARK 465 ARG B 1503
REMARK 465 ASP B 1504
REMARK 465 GLY B 1505
REMARK 465 TYR B 1506
REMARK 465 ARG B 1507
REMARK 465 GLN B 1508
REMARK 465 ALA B 1509
REMARK 465 GLY B 1510
REMARK 465 VAL B 1511
REMARK 465 SER B 1512
REMARK 465 GLY B 1513
REMARK 465 ARG B 1514
REMARK 465 VAL B 1515
REMARK 465 ARG B 1516
REMARK 465 SER B 1517
REMARK 465 TYR B 1518
REMARK 465 LEU B 1519
REMARK 465 ASP B 1520
REMARK 465 LEU B 1521
REMARK 465 LEU B 1522
REMARK 465 ALA B 1523
REMARK 465 GLY B 1524
REMARK 465 LEU B 1525
REMARK 465 SER B 1526
REMARK 465 ASP B 1527
REMARK 465 PHE B 1528
REMARK 465 ARG B 1529
REMARK 465 GLU B 1530
REMARK 465 HIS B 1531
REMARK 465 PHE B 1532
REMARK 465 ASP B 1533
REMARK 465 GLY B 1534
REMARK 465 SER B 1535
REMARK 465 ASP B 1536
REMARK 465 GLY B 1537
REMARK 465 PHE B 1538
REMARK 465 SER B 1539
REMARK 465 LEU B 1540
REMARK 465 ASP B 1541
REMARK 465 LEU B 1542
REMARK 465 VAL B 1543
REMARK 465 ASP B 1544
REMARK 465 MET B 1545
REMARK 465 ALA B 1546
REMARK 465 ASP B 1547
REMARK 465 GLY B 1548
REMARK 465 PRO B 1549
REMARK 465 GLY B 1550
REMARK 465 GLU B 1551
REMARK 465 VAL B 1552
REMARK 465 THR B 1553
REMARK 465 VAL B 1554
REMARK 465 ILE B 1555
REMARK 465 CYS B 1556
REMARK 465 CYS B 1557
REMARK 465 ALA B 1558
REMARK 465 GLY B 1559
REMARK 465 THR B 1560
REMARK 465 ALA B 1561
REMARK 465 ALA B 1562
REMARK 465 ILE B 1563
REMARK 465 SER B 1564
REMARK 465 GLY B 1565
REMARK 465 PRO B 1566
REMARK 465 HIS B 1567
REMARK 465 GLU B 1568
REMARK 465 PHE B 1569
REMARK 465 THR B 1570
REMARK 465 ARG B 1571
REMARK 465 LEU B 1572
REMARK 465 ALA B 1573
REMARK 465 GLY B 1574
REMARK 465 ALA B 1575
REMARK 465 LEU B 1576
REMARK 465 ARG B 1577
REMARK 465 GLY B 1578
REMARK 465 ILE B 1579
REMARK 465 ALA B 1580
REMARK 465 PRO B 1581
REMARK 465 VAL B 1582
REMARK 465 ARG B 1583
REMARK 465 ALA B 1584
REMARK 465 VAL B 1585
REMARK 465 PRO B 1586
REMARK 465 GLN B 1587
REMARK 465 PRO B 1588
REMARK 465 GLY B 1589
REMARK 465 TYR B 1590
REMARK 465 GLU B 1591
REMARK 465 GLU B 1592
REMARK 465 GLY B 1593
REMARK 465 GLU B 1594
REMARK 465 PRO B 1595
REMARK 465 LEU B 1596
REMARK 465 PRO B 1597
REMARK 465 SER B 1598
REMARK 465 SER B 1599
REMARK 465 MET B 1600
REMARK 465 ALA B 1601
REMARK 465 ALA B 1602
REMARK 465 VAL B 1603
REMARK 465 ALA B 1604
REMARK 465 ALA B 1605
REMARK 465 VAL B 1606
REMARK 465 GLN B 1607
REMARK 465 ALA B 1608
REMARK 465 ASP B 1609
REMARK 465 ALA B 1610
REMARK 465 VAL B 1611
REMARK 465 ILE B 1612
REMARK 465 ARG B 1613
REMARK 465 THR B 1614
REMARK 465 GLN B 1615
REMARK 465 GLY B 1616
REMARK 465 ASP B 1617
REMARK 465 LYS B 1618
REMARK 465 PRO B 1619
REMARK 465 PHE B 1620
REMARK 465 VAL B 1621
REMARK 465 VAL B 1622
REMARK 465 ALA B 1623
REMARK 465 GLY B 1624
REMARK 465 HIS B 1625
REMARK 465 SER B 1626
REMARK 465 ALA B 1627
REMARK 465 GLY B 1628
REMARK 465 ALA B 1629
REMARK 465 LEU B 1630
REMARK 465 MET B 1631
REMARK 465 ALA B 1632
REMARK 465 TYR B 1633
REMARK 465 ALA B 1634
REMARK 465 LEU B 1635
REMARK 465 ALA B 1636
REMARK 465 THR B 1637
REMARK 465 GLU B 1638
REMARK 465 LEU B 1639
REMARK 465 LEU B 1640
REMARK 465 ASP B 1641
REMARK 465 ARG B 1642
REMARK 465 GLY B 1643
REMARK 465 HIS B 1644
REMARK 465 PRO B 1645
REMARK 465 PRO B 1646
REMARK 465 ARG B 1647
REMARK 465 GLY B 1648
REMARK 465 VAL B 1649
REMARK 465 VAL B 1650
REMARK 465 LEU B 1651
REMARK 465 ILE B 1652
REMARK 465 ASP B 1653
REMARK 465 VAL B 1654
REMARK 465 TYR B 1655
REMARK 465 PRO B 1656
REMARK 465 PRO B 1657
REMARK 465 GLY B 1658
REMARK 465 HIS B 1659
REMARK 465 GLN B 1660
REMARK 465 ASP B 1661
REMARK 465 ALA B 1662
REMARK 465 MET B 1663
REMARK 465 ASN B 1664
REMARK 465 ALA B 1665
REMARK 465 TRP B 1666
REMARK 465 LEU B 1667
REMARK 465 GLU B 1668
REMARK 465 GLU B 1669
REMARK 465 LEU B 1670
REMARK 465 THR B 1671
REMARK 465 ALA B 1672
REMARK 465 THR B 1673
REMARK 465 LEU B 1674
REMARK 465 PHE B 1675
REMARK 465 ASP B 1676
REMARK 465 ARG B 1677
REMARK 465 GLU B 1678
REMARK 465 THR B 1679
REMARK 465 VAL B 1680
REMARK 465 ARG B 1681
REMARK 465 MET B 1682
REMARK 465 ASP B 1683
REMARK 465 ASP B 1684
REMARK 465 THR B 1685
REMARK 465 ARG B 1686
REMARK 465 LEU B 1687
REMARK 465 THR B 1688
REMARK 465 ALA B 1689
REMARK 465 LEU B 1690
REMARK 465 GLY B 1691
REMARK 465 ALA B 1692
REMARK 465 TYR B 1693
REMARK 465 ASP B 1694
REMARK 465 ARG B 1695
REMARK 465 LEU B 1696
REMARK 465 THR B 1697
REMARK 465 GLY B 1698
REMARK 465 GLN B 1699
REMARK 465 TRP B 1700
REMARK 465 ARG B 1701
REMARK 465 PRO B 1702
REMARK 465 ARG B 1703
REMARK 465 GLU B 1704
REMARK 465 THR B 1705
REMARK 465 GLY B 1706
REMARK 465 LEU B 1707
REMARK 465 PRO B 1708
REMARK 465 THR B 1709
REMARK 465 LEU B 1710
REMARK 465 LEU B 1711
REMARK 465 VAL B 1712
REMARK 465 SER B 1713
REMARK 465 ALA B 1714
REMARK 465 GLY B 1715
REMARK 465 GLU B 1716
REMARK 465 PRO B 1717
REMARK 465 MET B 1718
REMARK 465 GLY B 1719
REMARK 465 PRO B 1720
REMARK 465 TRP B 1721
REMARK 465 PRO B 1722
REMARK 465 ASP B 1723
REMARK 465 ASP B 1724
REMARK 465 SER B 1725
REMARK 465 TRP B 1726
REMARK 465 LYS B 1727
REMARK 465 PRO B 1728
REMARK 465 THR B 1729
REMARK 465 TRP B 1730
REMARK 465 PRO B 1731
REMARK 465 PHE B 1732
REMARK 465 GLU B 1733
REMARK 465 HIS B 1734
REMARK 465 ASP B 1735
REMARK 465 THR B 1736
REMARK 465 VAL B 1737
REMARK 465 ALA B 1738
REMARK 465 VAL B 1739
REMARK 465 PRO B 1740
REMARK 465 GLY B 1741
REMARK 465 ASP B 1742
REMARK 465 HIS B 1743
REMARK 465 PHE B 1744
REMARK 465 THR B 1745
REMARK 465 MET B 1746
REMARK 465 VAL B 1747
REMARK 465 GLN B 1748
REMARK 465 GLU B 1749
REMARK 465 HIS B 1750
REMARK 465 ALA B 1751
REMARK 465 ASP B 1752
REMARK 465 ALA B 1753
REMARK 465 ILE B 1754
REMARK 465 ALA B 1755
REMARK 465 ARG B 1756
REMARK 465 HIS B 1757
REMARK 465 ILE B 1758
REMARK 465 ASP B 1759
REMARK 465 ALA B 1760
REMARK 465 TRP B 1761
REMARK 465 LEU B 1762
REMARK 465 GLY B 1763
REMARK 465 GLY B 1764
REMARK 465 GLY B 1765
REMARK 465 ASN B 1766
REMARK 465 SER B 1767
REMARK 465 SER B 1768
REMARK 465 SER B 1769
REMARK 465 VAL B 1770
REMARK 465 ASP B 1771
REMARK 465 LYS B 1772
REMARK 465 LEU B 1773
REMARK 465 ALA B 1774
REMARK 465 ALA B 1775
REMARK 465 ALA B 1776
REMARK 465 LEU B 1777
REMARK 465 GLU B 1778
REMARK 465 HIS B 1779
REMARK 465 HIS B 1780
REMARK 465 HIS B 1781
REMARK 465 HIS B 1782
REMARK 465 HIS B 1783
REMARK 465 HIS B 1784
REMARK 465 MET C 1
REMARK 465 ALA C 2
REMARK 465 LYS C 136
REMARK 465 SER C 137
REMARK 465 THR C 138
REMARK 465 SER C 139
REMARK 465 GLY C 140
REMARK 465 GLY C 141
REMARK 465 THR C 142
REMARK 465 SER C 194
REMARK 465 SER C 195
REMARK 465 LEU C 196
REMARK 465 GLY C 197
REMARK 465 THR C 198
REMARK 465 GLN C 199
REMARK 465 LYS C 221
REMARK 465 SER C 222
REMARK 465 CYS C 223
REMARK 465 ALA C 224
REMARK 465 ALA C 225
REMARK 465 LEU C 226
REMARK 465 VAL C 227
REMARK 465 PRO C 228
REMARK 465 ARG C 229
REMARK 465 GLY C 230
REMARK 465 SER C 231
REMARK 465 ALA C 232
REMARK 465 HIS C 233
REMARK 465 HIS C 234
REMARK 465 HIS C 235
REMARK 465 HIS C 236
REMARK 465 HIS C 237
REMARK 465 HIS C 238
REMARK 465 ALA C 239
REMARK 465 ALA C 240
REMARK 465 ASP C 241
REMARK 465 TYR C 242
REMARK 465 LYS C 243
REMARK 465 ASP C 244
REMARK 465 ASP C 245
REMARK 465 ASP C 246
REMARK 465 ASP C 247
REMARK 465 LYS C 248
REMARK 465 ALA C 249
REMARK 465 LEU D 1
REMARK 465 PHE D 2
REMARK 465 ALA D 3
REMARK 465 ILE D 4
REMARK 465 PRO D 5
REMARK 465 LEU D 6
REMARK 465 VAL D 7
REMARK 465 VAL D 8
REMARK 465 PRO D 9
REMARK 465 PHE D 10
REMARK 465 TYR D 11
REMARK 465 SER D 12
REMARK 465 HIS D 13
REMARK 465 SER D 14
REMARK 465 ALA D 15
REMARK 465 LEU D 16
REMARK 465 ASP D 173
REMARK 465 ASN D 174
REMARK 465 ALA D 175
REMARK 465 LEU D 176
REMARK 465 LYS D 210
REMARK 465 HIS D 211
REMARK 465 LYS D 212
REMARK 465 VAL D 213
REMARK 465 TYR D 214
REMARK 465 ASN D 232
REMARK 465 ARG D 233
REMARK 465 GLY D 234
REMARK 465 GLU D 235
REMARK 465 CYS D 236
REMARK 465 MET E 1
REMARK 465 ALA E 2
REMARK 465 LYS E 136
REMARK 465 SER E 137
REMARK 465 THR E 138
REMARK 465 SER E 139
REMARK 465 GLY E 140
REMARK 465 GLY E 141
REMARK 465 THR E 142
REMARK 465 SER E 194
REMARK 465 SER E 195
REMARK 465 LEU E 196
REMARK 465 GLY E 197
REMARK 465 THR E 198
REMARK 465 GLN E 199
REMARK 465 LYS E 221
REMARK 465 SER E 222
REMARK 465 CYS E 223
REMARK 465 ALA E 224
REMARK 465 ALA E 225
REMARK 465 LEU E 226
REMARK 465 VAL E 227
REMARK 465 PRO E 228
REMARK 465 ARG E 229
REMARK 465 GLY E 230
REMARK 465 SER E 231
REMARK 465 ALA E 232
REMARK 465 HIS E 233
REMARK 465 HIS E 234
REMARK 465 HIS E 235
REMARK 465 HIS E 236
REMARK 465 HIS E 237
REMARK 465 HIS E 238
REMARK 465 ALA E 239
REMARK 465 ALA E 240
REMARK 465 ASP E 241
REMARK 465 TYR E 242
REMARK 465 LYS E 243
REMARK 465 ASP E 244
REMARK 465 ASP E 245
REMARK 465 ASP E 246
REMARK 465 ASP E 247
REMARK 465 LYS E 248
REMARK 465 ALA E 249
REMARK 465 LEU F 1
REMARK 465 PHE F 2
REMARK 465 ALA F 3
REMARK 465 ILE F 4
REMARK 465 PRO F 5
REMARK 465 LEU F 6
REMARK 465 VAL F 7
REMARK 465 VAL F 8
REMARK 465 PRO F 9
REMARK 465 PHE F 10
REMARK 465 TYR F 11
REMARK 465 SER F 12
REMARK 465 HIS F 13
REMARK 465 SER F 14
REMARK 465 ALA F 15
REMARK 465 LEU F 16
REMARK 465 ASP F 173
REMARK 465 ASN F 174
REMARK 465 ALA F 175
REMARK 465 LEU F 176
REMARK 465 GLN F 177
REMARK 465 HIS F 211
REMARK 465 LYS F 212
REMARK 465 VAL F 213
REMARK 465 TYR F 214
REMARK 465 ASN F 232
REMARK 465 ARG F 233
REMARK 465 GLY F 234
REMARK 465 GLU F 235
REMARK 465 CYS F 236
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470 M RES CSSEQI ATOMS
REMARK 470 LYS A 913 CG CD CE NZ
REMARK 470 ARG A 917 CG CD NE CZ NH1 NH2
REMARK 470 ARG A 918 CG CD NE CZ NH1 NH2
REMARK 470 ARG A 929 CG CD NE CZ NH1 NH2
REMARK 470 ARG A1354 CG CD NE CZ NH1 NH2
REMARK 470 LYS B 913 CG CD CE NZ
REMARK 470 ARG B 917 CG CD NE CZ NH1 NH2
REMARK 470 ARG B 918 CG CD NE CZ NH1 NH2
REMARK 470 ARG B1354 CG CD NE CZ NH1 NH2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE
REMARK 500 OE1 GLN C 178 OG SER C 184 2.15
REMARK 500 OE1 GLN E 178 OG SER E 184 2.15
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500 M RES CSSEQI ATM1 RES CSSEQI ATM2 DEVIATION
REMARK 500 ARG A 43 C ARG A 43 O -0.121
REMARK 500 PHE A 54 C PHE A 54 O -0.132
REMARK 500 LEU A 57 C LEU A 57 O -0.118
REMARK 500 SER A 59 CA SER A 59 CB -0.124
REMARK 500 PRO A 197 C PRO A 197 O -0.166
REMARK 500 GLY A 230 C GLY A 230 O -0.139
REMARK 500 GLU A 338 C GLU A 338 O -0.115
REMARK 500 VAL A 388 C VAL A 388 O -0.132
REMARK 500 THR A 399 C THR A 399 O -0.145
REMARK 500 GLY A 439 C GLY A 439 O -0.112
REMARK 500 VAL B 183 C VAL B 183 O -0.118
REMARK 500 SER B 207 CA SER B 207 CB -0.242
REMARK 500 VAL B 440 C VAL B 440 O -0.130
REMARK 500 SER B 441 CA SER B 441 CB -0.161
REMARK 500 SER B 442 CA SER B 442 CB -0.221
REMARK 500 SER B 442 C SER B 442 O -0.135
REMARK 500 SER C 37 CA SER C 37 CB -0.095
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3
REMARK 500 ASP A 5 CB - CA - C ANGL. DEV. = 13.6 DEGREES
REMARK 500 PHE A 54 CB - CA - C ANGL. DEV. = -14.6 DEGREES
REMARK 500 ARG A 72 CB - CG - CD ANGL. DEV. = -22.4 DEGREES
REMARK 500 PRO A 197 CB - CA - C ANGL. DEV. = -18.4 DEGREES
REMARK 500 ALA A 198 CB - CA - C ANGL. DEV. = -9.3 DEGREES
REMARK 500 ALA A 198 N - CA - CB ANGL. DEV. = -10.7 DEGREES
REMARK 500 PHE A 266 CB - CA - C ANGL. DEV. = -16.1 DEGREES
REMARK 500 PHE A 266 N - CA - CB ANGL. DEV. = 11.5 DEGREES
REMARK 500 PHE A 266 CA - CB - CG ANGL. DEV. = 17.7 DEGREES
REMARK 500 LYS A 390 CB - CA - C ANGL. DEV. = -12.5 DEGREES
REMARK 500 PRO A 401 N - CA - CB ANGL. DEV. = -11.4 DEGREES
REMARK 500 PRO A 401 N - CD - CG ANGL. DEV. = -14.0 DEGREES
REMARK 500 ARG A 491 CG - CD - NE ANGL. DEV. = -14.9 DEGREES
REMARK 500 PRO A 902 CB - CA - C ANGL. DEV. = -25.1 DEGREES
REMARK 500 ARG B 62 CB - CA - C ANGL. DEV. = -12.8 DEGREES
REMARK 500 ASP B 63 CB - CA - C ANGL. DEV. = -17.1 DEGREES
REMARK 500 PRO B 157 N - CA - CB ANGL. DEV. = -14.9 DEGREES
REMARK 500 GLU B 159 CB - CA - C ANGL. DEV. = -32.3 DEGREES
REMARK 500 PRO B 162 CA - N - CD ANGL. DEV. = -9.7 DEGREES
REMARK 500 PRO B 162 CB - CA - C ANGL. DEV. = -17.8 DEGREES
REMARK 500 PRO B 162 N - CA - CB ANGL. DEV. = -19.8 DEGREES
REMARK 500 TYR B 174 CB - CA - C ANGL. DEV. = -14.4 DEGREES
REMARK 500 THR B 233 CB - CA - C ANGL. DEV. = -21.1 DEGREES
REMARK 500 THR B 233 CA - CB - OG1 ANGL. DEV. = -21.5 DEGREES
REMARK 500 VAL B 234 N - CA - C ANGL. DEV. = -18.2 DEGREES
REMARK 500 PRO B 236 N - CA - CB ANGL. DEV. = -11.3 DEGREES
REMARK 500 PRO B 236 N - CD - CG ANGL. DEV. = -9.6 DEGREES
REMARK 500 ASP B 243 CB - CA - C ANGL. DEV. = -16.6 DEGREES
REMARK 500 GLU B 270 CB - CG - CD ANGL. DEV. = -19.9 DEGREES
REMARK 500 THR B 403 N - CA - C ANGL. DEV. = -20.2 DEGREES
REMARK 500 SER B 441 CB - CA - C ANGL. DEV. = -11.7 DEGREES
REMARK 500 THR C 101 N - CA - CB ANGL. DEV. = -14.9 DEGREES
REMARK 500 ARG C 102 CB - CA - C ANGL. DEV. = -20.5 DEGREES
REMARK 500 CYS E 100 CB - CA - C ANGL. DEV. = -12.9 DEGREES
REMARK 500 CYS E 100 CA - CB - SG ANGL. DEV. = 7.6 DEGREES
REMARK 500 THR E 101 N - CA - CB ANGL. DEV. = -12.0 DEGREES
REMARK 500 ARG E 102 CB - CA - C ANGL. DEV. = -20.5 DEGREES
REMARK 500 ASN F 180 CB - CA - C ANGL. DEV. = -13.8 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500 M RES CSSEQI PSI PHI
REMARK 500 SER A 3 70.50 58.68
REMARK 500 ASP A 5 -3.09 69.04
REMARK 500 LYS A 8 -57.46 -128.45
REMARK 500 LEU A 76 -6.07 75.16
REMARK 500 ARG A 93 33.61 -97.21
REMARK 500 LEU A 155 -161.97 -127.64
REMARK 500 GLN A 158 -148.46 55.62
REMARK 500 GLU A 159 116.19 -160.95
REMARK 500 TYR A 160 -74.18 -107.58
REMARK 500 ALA A 204 -118.78 58.24
REMARK 500 CYS A 205 3.52 -66.83
REMARK 500 ALA A 336 116.35 -161.04
REMARK 500 GLN A 380 -114.79 59.47
REMARK 500 PRO A 519 45.49 -78.15
REMARK 500 SER A 552 -169.22 -172.05
REMARK 500 ARG A 553 -47.33 -137.78
REMARK 500 TRP A 567 29.31 -153.60
REMARK 500 ASP A 575 51.06 -95.86
REMARK 500 ALA A 644 27.96 -149.12
REMARK 500 HIS A 645 56.58 -104.49
REMARK 500 SER A 656 -117.37 -154.37
REMARK 500 ASN A 691 31.68 -140.36
REMARK 500 HIS A 756 19.14 59.83
REMARK 500 SER A 758 107.04 -59.48
REMARK 500 TYR A 825 39.77 -152.16
REMARK 500 THR A 827 106.40 -162.32
REMARK 500 ALA A 854 64.92 -151.34
REMARK 500 LEU A 865 -116.94 56.26
REMARK 500 THR A 891 17.07 -147.11
REMARK 500 PRO A 902 68.80 -68.28
REMARK 500 ASP A 923 69.92 -101.51
REMARK 500 LYS A 953 -162.44 -164.57
REMARK 500 ASP A1010 58.43 39.79
REMARK 500 ASP A1177 30.29 -94.21
REMARK 500 ALA A1229 114.92 -161.76
REMARK 500 GLU A1342 1.69 -69.23
REMARK 500 ASP A1363 52.12 -109.89
REMARK 500 TYR A1373 -58.91 -136.67
REMARK 500 ALA B 2 -81.17 -117.41
REMARK 500 THR B 4 -127.52 47.83
REMARK 500 ASP B 5 31.91 -142.87
REMARK 500 LYS B 8 -45.26 -131.66
REMARK 500 TRP B 55 1.64 -69.55
REMARK 500 ALA B 66 -60.68 -98.84
REMARK 500 PRO B 148 108.70 -57.63
REMARK 500 PRO B 157 124.29 -39.24
REMARK 500 TYR B 160 -63.50 -100.30
REMARK 500 GLU B 172 -60.47 -138.53
REMARK 500 ALA B 204 -120.23 60.77
REMARK 500 PRO B 238 47.36 -77.71
REMARK 500
REMARK 500 THIS ENTRY HAS 121 RAMACHANDRAN OUTLIERS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS
REMARK 500
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH
REMARK 500 CIS AND TRANS CONFORMATION. CIS BONDS, IF ANY, ARE LISTED
REMARK 500 ON CISPEP RECORDS. TRANS IS DEFINED AS 180 +/- 30 AND
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.
REMARK 500 MODEL OMEGA
REMARK 500 GLU C 155 PRO C 156 78.74
REMARK 500 GLU E 155 PRO E 156 78.83
REMARK 500 THR F 115 PRO F 116 85.77
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: PLANAR GROUPS
REMARK 500
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS
REMARK 500 AN RMSD GREATER THAN THIS VALUE
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 M RES CSSEQI RMS TYPE
REMARK 500 ASP B 799 0.08 SIDE CHAIN
REMARK 500 ARG C 21 0.08 SIDE CHAIN
REMARK 500 ARG E 21 0.08 SIDE CHAIN
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: MAIN CHAIN PLANARITY
REMARK 500
REMARK 500 THE FOLLOWING RESIDUES HAVE A PSEUDO PLANARITY
REMARK 500 TORSION ANGLE, C(I) - CA(I) - N(I+1) - O(I), GREATER
REMARK 500 10.0 DEGREES. (M=MODEL NUMBER; RES=RESIDUE NAME;
REMARK 500 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 500 I=INSERTION CODE).
REMARK 500
REMARK 500 M RES CSSEQI ANGLE
REMARK 500 ASP A 545 11.61
REMARK 500 VAL B 171 -10.81
REMARK 500 ALA E 96 -11.46
REMARK 500
REMARK 500 REMARK: NULL
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: EMD-23712 RELATED DB: EMDB
REMARK 900 RELATED ID: EMD-23713 RELATED DB: EMDB
REMARK 900 RELATED ID: EMD-23715 RELATED DB: EMDB
REMARK 900 RELATED ID: EMD-23714 RELATED DB: EMDB
REMARK 900 RELATED ID: EMD-23710 RELATED DB: EMDB
REMARK 900 RELATED ID: EMD-23711 RELATED DB: EMDB
DBREF 7M7G A 32 1485 UNP Q5UNP6 Q5UNP6_SACER 557 2010
DBREF 7M7G A 1491 1767 UNP Q03133 ERYA3_SACER 2896 3172
DBREF 7M7G B 32 1485 UNP Q5UNP6 Q5UNP6_SACER 557 2010
DBREF 7M7G B 1491 1767 UNP Q03133 ERYA3_SACER 2896 3172
DBREF 7M7G C 1 249 PDB 7M7G 7M7G 1 249
DBREF 7M7G D 1 236 PDB 7M7G 7M7G 1 236
DBREF 7M7G E 1 249 PDB 7M7G 7M7G 1 249
DBREF 7M7G F 1 236 PDB 7M7G 7M7G 1 236
SEQADV 7M7G MET A 1 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G ALA A 2 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G SER A 3 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G THR A 4 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G ASP A 5 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G SER A 6 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G GLU A 7 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G LYS A 8 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G VAL A 9 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G ALA A 10 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G GLU A 11 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G TYR A 12 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G LEU A 13 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G ARG A 14 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G ARG A 15 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G ALA A 16 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G THR A 17 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G LEU A 18 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G ASP A 19 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G LEU A 20 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G ARG A 21 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G ALA A 22 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G ALA A 23 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G ARG A 24 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G GLN A 25 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G ARG A 26 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G ILE A 27 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G ARG A 28 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G GLU A 29 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G LEU A 30 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G GLU A 31 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G THR A 1486 UNP Q5UNP6 LINKER
SEQADV 7M7G SER A 1487 UNP Q5UNP6 LINKER
SEQADV 7M7G GLU A 1488 UNP Q5UNP6 LINKER
SEQADV 7M7G LEU A 1489 UNP Q5UNP6 LINKER
SEQADV 7M7G GLY A 1490 UNP Q5UNP6 LINKER
SEQADV 7M7G SER A 1768 UNP Q03133 EXPRESSION TAG
SEQADV 7M7G SER A 1769 UNP Q03133 EXPRESSION TAG
SEQADV 7M7G VAL A 1770 UNP Q03133 EXPRESSION TAG
SEQADV 7M7G ASP A 1771 UNP Q03133 EXPRESSION TAG
SEQADV 7M7G LYS A 1772 UNP Q03133 EXPRESSION TAG
SEQADV 7M7G LEU A 1773 UNP Q03133 EXPRESSION TAG
SEQADV 7M7G ALA A 1774 UNP Q03133 EXPRESSION TAG
SEQADV 7M7G ALA A 1775 UNP Q03133 EXPRESSION TAG
SEQADV 7M7G ALA A 1776 UNP Q03133 EXPRESSION TAG
SEQADV 7M7G LEU A 1777 UNP Q03133 EXPRESSION TAG
SEQADV 7M7G GLU A 1778 UNP Q03133 EXPRESSION TAG
SEQADV 7M7G HIS A 1779 UNP Q03133 EXPRESSION TAG
SEQADV 7M7G HIS A 1780 UNP Q03133 EXPRESSION TAG
SEQADV 7M7G HIS A 1781 UNP Q03133 EXPRESSION TAG
SEQADV 7M7G HIS A 1782 UNP Q03133 EXPRESSION TAG
SEQADV 7M7G HIS A 1783 UNP Q03133 EXPRESSION TAG
SEQADV 7M7G HIS A 1784 UNP Q03133 EXPRESSION TAG
SEQADV 7M7G MET B 1 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G ALA B 2 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G SER B 3 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G THR B 4 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G ASP B 5 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G SER B 6 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G GLU B 7 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G LYS B 8 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G VAL B 9 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G ALA B 10 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G GLU B 11 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G TYR B 12 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G LEU B 13 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G ARG B 14 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G ARG B 15 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G ALA B 16 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G THR B 17 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G LEU B 18 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G ASP B 19 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G LEU B 20 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G ARG B 21 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G ALA B 22 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G ALA B 23 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G ARG B 24 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G GLN B 25 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G ARG B 26 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G ILE B 27 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G ARG B 28 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G GLU B 29 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G LEU B 30 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G GLU B 31 UNP Q5UNP6 EXPRESSION TAG
SEQADV 7M7G THR B 1486 UNP Q5UNP6 LINKER
SEQADV 7M7G SER B 1487 UNP Q5UNP6 LINKER
SEQADV 7M7G GLU B 1488 UNP Q5UNP6 LINKER
SEQADV 7M7G LEU B 1489 UNP Q5UNP6 LINKER
SEQADV 7M7G GLY B 1490 UNP Q5UNP6 LINKER
SEQADV 7M7G SER B 1768 UNP Q03133 EXPRESSION TAG
SEQADV 7M7G SER B 1769 UNP Q03133 EXPRESSION TAG
SEQADV 7M7G VAL B 1770 UNP Q03133 EXPRESSION TAG
SEQADV 7M7G ASP B 1771 UNP Q03133 EXPRESSION TAG
SEQADV 7M7G LYS B 1772 UNP Q03133 EXPRESSION TAG
SEQADV 7M7G LEU B 1773 UNP Q03133 EXPRESSION TAG
SEQADV 7M7G ALA B 1774 UNP Q03133 EXPRESSION TAG
SEQADV 7M7G ALA B 1775 UNP Q03133 EXPRESSION TAG
SEQADV 7M7G ALA B 1776 UNP Q03133 EXPRESSION TAG
SEQADV 7M7G LEU B 1777 UNP Q03133 EXPRESSION TAG
SEQADV 7M7G GLU B 1778 UNP Q03133 EXPRESSION TAG
SEQADV 7M7G HIS B 1779 UNP Q03133 EXPRESSION TAG
SEQADV 7M7G HIS B 1780 UNP Q03133 EXPRESSION TAG
SEQADV 7M7G HIS B 1781 UNP Q03133 EXPRESSION TAG
SEQADV 7M7G HIS B 1782 UNP Q03133 EXPRESSION TAG
SEQADV 7M7G HIS B 1783 UNP Q03133 EXPRESSION TAG
SEQADV 7M7G HIS B 1784 UNP Q03133 EXPRESSION TAG
SEQRES 1 A 1784 MET ALA SER THR ASP SER GLU LYS VAL ALA GLU TYR LEU
SEQRES 2 A 1784 ARG ARG ALA THR LEU ASP LEU ARG ALA ALA ARG GLN ARG
SEQRES 3 A 1784 ILE ARG GLU LEU GLU GLY GLU PRO VAL ALA VAL VAL ALA
SEQRES 4 A 1784 MET ALA CYS ARG LEU PRO GLY GLY VAL SER THR PRO GLU
SEQRES 5 A 1784 GLU PHE TRP GLU LEU LEU SER GLU GLY ARG ASP ALA VAL
SEQRES 6 A 1784 ALA GLY LEU PRO THR ASP ARG GLY TRP ASP LEU ASP SER
SEQRES 7 A 1784 LEU PHE HIS PRO ASP PRO THR ARG SER GLY THR ALA HIS
SEQRES 8 A 1784 GLN ARG GLY GLY GLY PHE LEU THR GLU ALA THR ALA PHE
SEQRES 9 A 1784 ASP PRO ALA PHE PHE GLY MET SER PRO ARG GLU ALA LEU
SEQRES 10 A 1784 ALA VAL ASP PRO GLN GLN ARG LEU MET LEU GLU LEU SER
SEQRES 11 A 1784 TRP GLU VAL LEU GLU ARG ALA GLY ILE PRO PRO THR SER
SEQRES 12 A 1784 LEU GLN ALA SER PRO THR GLY VAL PHE VAL GLY LEU ILE
SEQRES 13 A 1784 PRO GLN GLU TYR GLY PRO ARG LEU ALA GLU GLY GLY GLU
SEQRES 14 A 1784 GLY VAL GLU GLY TYR LEU MET THR GLY THR THR THR SER
SEQRES 15 A 1784 VAL ALA SER GLY ARG ILE ALA TYR THR LEU GLY LEU GLU
SEQRES 16 A 1784 GLY PRO ALA ILE SER VAL ASP THR ALA CYS SER SER SER
SEQRES 17 A 1784 LEU VAL ALA VAL HIS LEU ALA CYS GLN SER LEU ARG ARG
SEQRES 18 A 1784 GLY GLU SER SER LEU ALA MET ALA GLY GLY VAL THR VAL
SEQRES 19 A 1784 MET PRO THR PRO GLY MET LEU VAL ASP PHE SER ARG MET
SEQRES 20 A 1784 ASN SER LEU ALA PRO ASP GLY ARG CYS LYS ALA PHE SER
SEQRES 21 A 1784 ALA GLY ALA ASN GLY PHE GLY MET ALA GLU GLY ALA GLY
SEQRES 22 A 1784 MET LEU LEU LEU GLU ARG LEU SER ASP ALA ARG ARG ASN
SEQRES 23 A 1784 GLY HIS PRO VAL LEU ALA VAL LEU ARG GLY THR ALA VAL
SEQRES 24 A 1784 ASN SER ASP GLY ALA SER ASN GLY LEU SER ALA PRO ASN
SEQRES 25 A 1784 GLY ARG ALA GLN VAL ARG VAL ILE GLN GLN ALA LEU ALA
SEQRES 26 A 1784 GLU SER GLY LEU GLY PRO ALA ASP ILE ASP ALA VAL GLU
SEQRES 27 A 1784 ALA HIS GLY THR GLY THR ARG LEU GLY ASP PRO ILE GLU
SEQRES 28 A 1784 ALA ARG ALA LEU PHE GLU ALA TYR GLY ARG ASP ARG GLU
SEQRES 29 A 1784 GLN PRO LEU HIS LEU GLY SER VAL LYS SER ASN LEU GLY
SEQRES 30 A 1784 HIS THR GLN ALA ALA ALA GLY VAL ALA GLY VAL ILE LYS
SEQRES 31 A 1784 MET VAL LEU ALA MET ARG ALA GLY THR LEU PRO ARG THR
SEQRES 32 A 1784 LEU HIS ALA SER GLU ARG SER LYS GLU ILE ASP TRP SER
SEQRES 33 A 1784 SER GLY ALA ILE SER LEU LEU ASP GLU PRO GLU PRO TRP
SEQRES 34 A 1784 PRO ALA GLY ALA ARG PRO ARG ARG ALA GLY VAL SER SER
SEQRES 35 A 1784 PHE GLY ILE SER GLY THR ASN ALA HIS ALA ILE ILE GLU
SEQRES 36 A 1784 GLU ALA PRO GLN VAL VAL GLU GLY GLU ARG VAL GLU ALA
SEQRES 37 A 1784 GLY ASP VAL VAL ALA PRO TRP VAL LEU SER ALA SER SER
SEQRES 38 A 1784 ALA GLU GLY LEU ARG ALA GLN ALA ALA ARG LEU ALA ALA
SEQRES 39 A 1784 HIS LEU ARG GLU HIS PRO GLY GLN ASP PRO ARG ASP ILE
SEQRES 40 A 1784 ALA TYR SER LEU ALA THR GLY ARG ALA ALA LEU PRO HIS
SEQRES 41 A 1784 ARG ALA ALA PHE ALA PRO VAL ASP GLU SER ALA ALA LEU
SEQRES 42 A 1784 ARG VAL LEU ASP GLY LEU ALA THR GLY ASN ALA ASP GLY
SEQRES 43 A 1784 ALA ALA VAL GLY THR SER ARG ALA GLN GLN ARG ALA VAL
SEQRES 44 A 1784 PHE VAL PHE PRO GLY GLN GLY TRP GLN TRP ALA GLY MET
SEQRES 45 A 1784 ALA VAL ASP LEU LEU ASP THR SER PRO VAL PHE ALA ALA
SEQRES 46 A 1784 ALA LEU ARG GLU CYS ALA ASP ALA LEU GLU PRO HIS LEU
SEQRES 47 A 1784 ASP PHE GLU VAL ILE PRO PHE LEU ARG ALA GLU ALA ALA
SEQRES 48 A 1784 ARG ARG GLU GLN ASP ALA ALA LEU SER THR GLU ARG VAL
SEQRES 49 A 1784 ASP VAL VAL GLN PRO VAL MET PHE ALA VAL MET VAL SER
SEQRES 50 A 1784 LEU ALA SER MET TRP ARG ALA HIS GLY VAL GLU PRO ALA
SEQRES 51 A 1784 ALA VAL ILE GLY HIS SER GLN GLY GLU ILE ALA ALA ALA
SEQRES 52 A 1784 CYS VAL ALA GLY ALA LEU SER LEU ASP ASP ALA ALA ARG
SEQRES 53 A 1784 VAL VAL ALA LEU ARG SER ARG VAL ILE ALA THR MET PRO
SEQRES 54 A 1784 GLY ASN LYS GLY MET ALA SER ILE ALA ALA PRO ALA GLY
SEQRES 55 A 1784 GLU VAL ARG ALA ARG ILE GLY ASP ARG VAL GLU ILE ALA
SEQRES 56 A 1784 ALA VAL ASN GLY PRO ARG SER VAL VAL VAL ALA GLY ASP
SEQRES 57 A 1784 SER ASP GLU LEU ASP ARG LEU VAL ALA SER CYS THR THR
SEQRES 58 A 1784 GLU CYS ILE ARG ALA LYS ARG LEU ALA VAL ASP TYR ALA
SEQRES 59 A 1784 SER HIS SER SER HIS VAL GLU THR ILE ARG ASP ALA LEU
SEQRES 60 A 1784 HIS ALA GLU LEU GLY GLU ASP PHE HIS PRO LEU PRO GLY
SEQRES 61 A 1784 PHE VAL PRO PHE PHE SER THR VAL THR GLY ARG TRP THR
SEQRES 62 A 1784 GLN PRO ASP GLU LEU ASP ALA GLY TYR TRP TYR ARG ASN
SEQRES 63 A 1784 LEU ARG ARG THR VAL ARG PHE ALA ASP ALA VAL ARG ALA
SEQRES 64 A 1784 LEU ALA GLU GLN GLY TYR ARG THR PHE LEU GLU VAL SER
SEQRES 65 A 1784 ALA HIS PRO ILE LEU THR ALA ALA ILE GLU GLU ILE GLY
SEQRES 66 A 1784 ASP GLY SER GLY ALA ASP LEU SER ALA ILE HIS SER LEU
SEQRES 67 A 1784 ARG ARG GLY ASP GLY SER LEU ALA ASP PHE GLY GLU ALA
SEQRES 68 A 1784 LEU SER ARG ALA PHE ALA ALA GLY VAL ALA VAL ASP TRP
SEQRES 69 A 1784 GLU SER VAL HIS LEU GLY THR GLY ALA ARG ARG VAL PRO
SEQRES 70 A 1784 LEU PRO THR TYR PRO PHE GLN ARG GLU ARG VAL TRP LEU
SEQRES 71 A 1784 GLU PRO LYS PRO VAL ALA ARG ARG SER THR GLU VAL ASP
SEQRES 72 A 1784 GLU VAL SER ALA LEU ARG TYR ARG ILE GLU TRP ARG PRO
SEQRES 73 A 1784 THR GLY ALA GLY GLU PRO ALA ARG LEU ASP GLY THR TRP
SEQRES 74 A 1784 LEU VAL ALA LYS TYR ALA GLY THR ALA ASP GLU THR SER
SEQRES 75 A 1784 THR ALA ALA ARG GLU ALA LEU GLU SER ALA GLY ALA ARG
SEQRES 76 A 1784 VAL ARG GLU LEU VAL VAL ASP ALA ARG CYS GLY ARG ASP
SEQRES 77 A 1784 GLU LEU ALA GLU ARG LEU ARG SER VAL GLY GLU VAL ALA
SEQRES 78 A 1784 GLY VAL LEU SER LEU LEU ALA VAL ASP GLU ALA GLU PRO
SEQRES 79 A 1784 GLU GLU ALA PRO LEU ALA LEU ALA SER LEU ALA ASP THR
SEQRES 80 A 1784 LEU SER LEU VAL GLN ALA MET VAL SER ALA GLU LEU GLY
SEQRES 81 A 1784 CYS PRO LEU TRP THR VAL THR GLU SER ALA VAL ALA THR
SEQRES 82 A 1784 GLY PRO PHE GLU ARG VAL ARG ASN ALA ALA HIS GLY ALA
SEQRES 83 A 1784 LEU TRP GLY VAL GLY ARG VAL ILE ALA LEU GLU ASN PRO
SEQRES 84 A 1784 ALA VAL TRP GLY GLY LEU VAL ASP VAL PRO ALA GLY SER
SEQRES 85 A 1784 VAL ALA GLU LEU ALA ARG HIS LEU ALA ALA VAL VAL SER
SEQRES 86 A 1784 GLY GLY ALA GLY GLU ASP GLN LEU ALA LEU ARG ALA ASP
SEQRES 87 A 1784 GLY VAL TYR GLY ARG ARG TRP VAL ARG ALA ALA ALA PRO
SEQRES 88 A 1784 ALA THR ASP ASP GLU TRP LYS PRO THR GLY THR VAL LEU
SEQRES 89 A 1784 VAL THR GLY GLY THR GLY GLY VAL GLY GLY GLN ILE ALA
SEQRES 90 A 1784 ARG TRP LEU ALA ARG ARG GLY ALA PRO HIS LEU LEU LEU
SEQRES 91 A 1784 VAL SER ARG SER GLY PRO ASP ALA ASP GLY ALA GLY GLU
SEQRES 92 A 1784 LEU VAL ALA GLU LEU GLU ALA LEU GLY ALA ARG THR THR
SEQRES 93 A 1784 VAL ALA ALA CYS ASP VAL THR ASP ARG GLU SER VAL ARG
SEQRES 94 A 1784 GLU LEU LEU GLY GLY ILE GLY ASP ASP VAL PRO LEU SER
SEQRES 95 A 1784 ALA VAL PHE HIS ALA ALA ALA THR LEU ASP ASP GLY THR
SEQRES 96 A 1784 VAL ASP THR LEU THR GLY GLU ARG ILE GLU ARG ALA SER
SEQRES 97 A 1784 ARG ALA LYS VAL LEU GLY ALA ARG ASN LEU HIS GLU LEU
SEQRES 98 A 1784 THR ARG GLU LEU ASP LEU THR ALA PHE VAL LEU PHE SER
SEQRES 99 A 1784 SER PHE ALA SER ALA PHE GLY ALA PRO GLY LEU GLY GLY
SEQRES 100 A 1784 TYR ALA PRO GLY ASN ALA TYR LEU ASP GLY LEU ALA GLN
SEQRES 101 A 1784 GLN ARG ARG SER ASP GLY LEU PRO ALA THR ALA VAL ALA
SEQRES 102 A 1784 TRP GLY THR TRP ALA GLY SER GLY MET ALA GLU GLY PRO
SEQRES 103 A 1784 VAL ALA ASP ARG PHE ARG ARG HIS GLY VAL ILE GLU MET
SEQRES 104 A 1784 PRO PRO GLU THR ALA CYS ARG ALA LEU GLN ASN ALA LEU
SEQRES 105 A 1784 ASP ARG ALA GLU VAL CYS PRO ILE VAL ILE ASP VAL ARG
SEQRES 106 A 1784 TRP ASP ARG PHE LEU LEU ALA TYR THR ALA GLN ARG PRO
SEQRES 107 A 1784 THR ARG LEU PHE ASP GLU ILE ASP ASP ALA ARG ARG ALA
SEQRES 108 A 1784 ALA PRO GLN ALA ALA ALA GLU PRO ARG VAL GLY ALA LEU
SEQRES 109 A 1784 ALA SER LEU PRO ALA PRO GLU ARG GLU LYS ALA LEU PHE
SEQRES 110 A 1784 GLU LEU VAL ARG SER HIS ALA ALA ALA VAL LEU GLY HIS
SEQRES 111 A 1784 ALA SER ALA GLU ARG VAL PRO ALA ASP GLN ALA PHE ALA
SEQRES 112 A 1784 GLU LEU GLY VAL ASP SER LEU SER ALA LEU GLU LEU ARG
SEQRES 113 A 1784 ASN ARG LEU GLY ALA ALA THR GLY VAL ARG LEU PRO THR
SEQRES 114 A 1784 THR THR VAL PHE ASP HIS PRO ASP VAL ARG THR LEU ALA
SEQRES 115 A 1784 ALA HIS LEU THR SER GLU LEU GLY SER GLY THR PRO ALA
SEQRES 116 A 1784 ARG GLU ALA SER SER ALA LEU ARG ASP GLY TYR ARG GLN
SEQRES 117 A 1784 ALA GLY VAL SER GLY ARG VAL ARG SER TYR LEU ASP LEU
SEQRES 118 A 1784 LEU ALA GLY LEU SER ASP PHE ARG GLU HIS PHE ASP GLY
SEQRES 119 A 1784 SER ASP GLY PHE SER LEU ASP LEU VAL ASP MET ALA ASP
SEQRES 120 A 1784 GLY PRO GLY GLU VAL THR VAL ILE CYS CYS ALA GLY THR
SEQRES 121 A 1784 ALA ALA ILE SER GLY PRO HIS GLU PHE THR ARG LEU ALA
SEQRES 122 A 1784 GLY ALA LEU ARG GLY ILE ALA PRO VAL ARG ALA VAL PRO
SEQRES 123 A 1784 GLN PRO GLY TYR GLU GLU GLY GLU PRO LEU PRO SER SER
SEQRES 124 A 1784 MET ALA ALA VAL ALA ALA VAL GLN ALA ASP ALA VAL ILE
SEQRES 125 A 1784 ARG THR GLN GLY ASP LYS PRO PHE VAL VAL ALA GLY HIS
SEQRES 126 A 1784 SER ALA GLY ALA LEU MET ALA TYR ALA LEU ALA THR GLU
SEQRES 127 A 1784 LEU LEU ASP ARG GLY HIS PRO PRO ARG GLY VAL VAL LEU
SEQRES 128 A 1784 ILE ASP VAL TYR PRO PRO GLY HIS GLN ASP ALA MET ASN
SEQRES 129 A 1784 ALA TRP LEU GLU GLU LEU THR ALA THR LEU PHE ASP ARG
SEQRES 130 A 1784 GLU THR VAL ARG MET ASP ASP THR ARG LEU THR ALA LEU
SEQRES 131 A 1784 GLY ALA TYR ASP ARG LEU THR GLY GLN TRP ARG PRO ARG
SEQRES 132 A 1784 GLU THR GLY LEU PRO THR LEU LEU VAL SER ALA GLY GLU
SEQRES 133 A 1784 PRO MET GLY PRO TRP PRO ASP ASP SER TRP LYS PRO THR
SEQRES 134 A 1784 TRP PRO PHE GLU HIS ASP THR VAL ALA VAL PRO GLY ASP
SEQRES 135 A 1784 HIS PHE THR MET VAL GLN GLU HIS ALA ASP ALA ILE ALA
SEQRES 136 A 1784 ARG HIS ILE ASP ALA TRP LEU GLY GLY GLY ASN SER SER
SEQRES 137 A 1784 SER VAL ASP LYS LEU ALA ALA ALA LEU GLU HIS HIS HIS
SEQRES 138 A 1784 HIS HIS HIS
SEQRES 1 B 1784 MET ALA SER THR ASP SER GLU LYS VAL ALA GLU TYR LEU
SEQRES 2 B 1784 ARG ARG ALA THR LEU ASP LEU ARG ALA ALA ARG GLN ARG
SEQRES 3 B 1784 ILE ARG GLU LEU GLU GLY GLU PRO VAL ALA VAL VAL ALA
SEQRES 4 B 1784 MET ALA CYS ARG LEU PRO GLY GLY VAL SER THR PRO GLU
SEQRES 5 B 1784 GLU PHE TRP GLU LEU LEU SER GLU GLY ARG ASP ALA VAL
SEQRES 6 B 1784 ALA GLY LEU PRO THR ASP ARG GLY TRP ASP LEU ASP SER
SEQRES 7 B 1784 LEU PHE HIS PRO ASP PRO THR ARG SER GLY THR ALA HIS
SEQRES 8 B 1784 GLN ARG GLY GLY GLY PHE LEU THR GLU ALA THR ALA PHE
SEQRES 9 B 1784 ASP PRO ALA PHE PHE GLY MET SER PRO ARG GLU ALA LEU
SEQRES 10 B 1784 ALA VAL ASP PRO GLN GLN ARG LEU MET LEU GLU LEU SER
SEQRES 11 B 1784 TRP GLU VAL LEU GLU ARG ALA GLY ILE PRO PRO THR SER
SEQRES 12 B 1784 LEU GLN ALA SER PRO THR GLY VAL PHE VAL GLY LEU ILE
SEQRES 13 B 1784 PRO GLN GLU TYR GLY PRO ARG LEU ALA GLU GLY GLY GLU
SEQRES 14 B 1784 GLY VAL GLU GLY TYR LEU MET THR GLY THR THR THR SER
SEQRES 15 B 1784 VAL ALA SER GLY ARG ILE ALA TYR THR LEU GLY LEU GLU
SEQRES 16 B 1784 GLY PRO ALA ILE SER VAL ASP THR ALA CYS SER SER SER
SEQRES 17 B 1784 LEU VAL ALA VAL HIS LEU ALA CYS GLN SER LEU ARG ARG
SEQRES 18 B 1784 GLY GLU SER SER LEU ALA MET ALA GLY GLY VAL THR VAL
SEQRES 19 B 1784 MET PRO THR PRO GLY MET LEU VAL ASP PHE SER ARG MET
SEQRES 20 B 1784 ASN SER LEU ALA PRO ASP GLY ARG CYS LYS ALA PHE SER
SEQRES 21 B 1784 ALA GLY ALA ASN GLY PHE GLY MET ALA GLU GLY ALA GLY
SEQRES 22 B 1784 MET LEU LEU LEU GLU ARG LEU SER ASP ALA ARG ARG ASN
SEQRES 23 B 1784 GLY HIS PRO VAL LEU ALA VAL LEU ARG GLY THR ALA VAL
SEQRES 24 B 1784 ASN SER ASP GLY ALA SER ASN GLY LEU SER ALA PRO ASN
SEQRES 25 B 1784 GLY ARG ALA GLN VAL ARG VAL ILE GLN GLN ALA LEU ALA
SEQRES 26 B 1784 GLU SER GLY LEU GLY PRO ALA ASP ILE ASP ALA VAL GLU
SEQRES 27 B 1784 ALA HIS GLY THR GLY THR ARG LEU GLY ASP PRO ILE GLU
SEQRES 28 B 1784 ALA ARG ALA LEU PHE GLU ALA TYR GLY ARG ASP ARG GLU
SEQRES 29 B 1784 GLN PRO LEU HIS LEU GLY SER VAL LYS SER ASN LEU GLY
SEQRES 30 B 1784 HIS THR GLN ALA ALA ALA GLY VAL ALA GLY VAL ILE LYS
SEQRES 31 B 1784 MET VAL LEU ALA MET ARG ALA GLY THR LEU PRO ARG THR
SEQRES 32 B 1784 LEU HIS ALA SER GLU ARG SER LYS GLU ILE ASP TRP SER
SEQRES 33 B 1784 SER GLY ALA ILE SER LEU LEU ASP GLU PRO GLU PRO TRP
SEQRES 34 B 1784 PRO ALA GLY ALA ARG PRO ARG ARG ALA GLY VAL SER SER
SEQRES 35 B 1784 PHE GLY ILE SER GLY THR ASN ALA HIS ALA ILE ILE GLU
SEQRES 36 B 1784 GLU ALA PRO GLN VAL VAL GLU GLY GLU ARG VAL GLU ALA
SEQRES 37 B 1784 GLY ASP VAL VAL ALA PRO TRP VAL LEU SER ALA SER SER
SEQRES 38 B 1784 ALA GLU GLY LEU ARG ALA GLN ALA ALA ARG LEU ALA ALA
SEQRES 39 B 1784 HIS LEU ARG GLU HIS PRO GLY GLN ASP PRO ARG ASP ILE
SEQRES 40 B 1784 ALA TYR SER LEU ALA THR GLY ARG ALA ALA LEU PRO HIS
SEQRES 41 B 1784 ARG ALA ALA PHE ALA PRO VAL ASP GLU SER ALA ALA LEU
SEQRES 42 B 1784 ARG VAL LEU ASP GLY LEU ALA THR GLY ASN ALA ASP GLY
SEQRES 43 B 1784 ALA ALA VAL GLY THR SER ARG ALA GLN GLN ARG ALA VAL
SEQRES 44 B 1784 PHE VAL PHE PRO GLY GLN GLY TRP GLN TRP ALA GLY MET
SEQRES 45 B 1784 ALA VAL ASP LEU LEU ASP THR SER PRO VAL PHE ALA ALA
SEQRES 46 B 1784 ALA LEU ARG GLU CYS ALA ASP ALA LEU GLU PRO HIS LEU
SEQRES 47 B 1784 ASP PHE GLU VAL ILE PRO PHE LEU ARG ALA GLU ALA ALA
SEQRES 48 B 1784 ARG ARG GLU GLN ASP ALA ALA LEU SER THR GLU ARG VAL
SEQRES 49 B 1784 ASP VAL VAL GLN PRO VAL MET PHE ALA VAL MET VAL SER
SEQRES 50 B 1784 LEU ALA SER MET TRP ARG ALA HIS GLY VAL GLU PRO ALA
SEQRES 51 B 1784 ALA VAL ILE GLY HIS SER GLN GLY GLU ILE ALA ALA ALA
SEQRES 52 B 1784 CYS VAL ALA GLY ALA LEU SER LEU ASP ASP ALA ALA ARG
SEQRES 53 B 1784 VAL VAL ALA LEU ARG SER ARG VAL ILE ALA THR MET PRO
SEQRES 54 B 1784 GLY ASN LYS GLY MET ALA SER ILE ALA ALA PRO ALA GLY
SEQRES 55 B 1784 GLU VAL ARG ALA ARG ILE GLY ASP ARG VAL GLU ILE ALA
SEQRES 56 B 1784 ALA VAL ASN GLY PRO ARG SER VAL VAL VAL ALA GLY ASP
SEQRES 57 B 1784 SER ASP GLU LEU ASP ARG LEU VAL ALA SER CYS THR THR
SEQRES 58 B 1784 GLU CYS ILE ARG ALA LYS ARG LEU ALA VAL ASP TYR ALA
SEQRES 59 B 1784 SER HIS SER SER HIS VAL GLU THR ILE ARG ASP ALA LEU
SEQRES 60 B 1784 HIS ALA GLU LEU GLY GLU ASP PHE HIS PRO LEU PRO GLY
SEQRES 61 B 1784 PHE VAL PRO PHE PHE SER THR VAL THR GLY ARG TRP THR
SEQRES 62 B 1784 GLN PRO ASP GLU LEU ASP ALA GLY TYR TRP TYR ARG ASN
SEQRES 63 B 1784 LEU ARG ARG THR VAL ARG PHE ALA ASP ALA VAL ARG ALA
SEQRES 64 B 1784 LEU ALA GLU GLN GLY TYR ARG THR PHE LEU GLU VAL SER
SEQRES 65 B 1784 ALA HIS PRO ILE LEU THR ALA ALA ILE GLU GLU ILE GLY
SEQRES 66 B 1784 ASP GLY SER GLY ALA ASP LEU SER ALA ILE HIS SER LEU
SEQRES 67 B 1784 ARG ARG GLY ASP GLY SER LEU ALA ASP PHE GLY GLU ALA
SEQRES 68 B 1784 LEU SER ARG ALA PHE ALA ALA GLY VAL ALA VAL ASP TRP
SEQRES 69 B 1784 GLU SER VAL HIS LEU GLY THR GLY ALA ARG ARG VAL PRO
SEQRES 70 B 1784 LEU PRO THR TYR PRO PHE GLN ARG GLU ARG VAL TRP LEU
SEQRES 71 B 1784 GLU PRO LYS PRO VAL ALA ARG ARG SER THR GLU VAL ASP
SEQRES 72 B 1784 GLU VAL SER ALA LEU ARG TYR ARG ILE GLU TRP ARG PRO
SEQRES 73 B 1784 THR GLY ALA GLY GLU PRO ALA ARG LEU ASP GLY THR TRP
SEQRES 74 B 1784 LEU VAL ALA LYS TYR ALA GLY THR ALA ASP GLU THR SER
SEQRES 75 B 1784 THR ALA ALA ARG GLU ALA LEU GLU SER ALA GLY ALA ARG
SEQRES 76 B 1784 VAL ARG GLU LEU VAL VAL ASP ALA ARG CYS GLY ARG ASP
SEQRES 77 B 1784 GLU LEU ALA GLU ARG LEU ARG SER VAL GLY GLU VAL ALA
SEQRES 78 B 1784 GLY VAL LEU SER LEU LEU ALA VAL ASP GLU ALA GLU PRO
SEQRES 79 B 1784 GLU GLU ALA PRO LEU ALA LEU ALA SER LEU ALA ASP THR
SEQRES 80 B 1784 LEU SER LEU VAL GLN ALA MET VAL SER ALA GLU LEU GLY
SEQRES 81 B 1784 CYS PRO LEU TRP THR VAL THR GLU SER ALA VAL ALA THR
SEQRES 82 B 1784 GLY PRO PHE GLU ARG VAL ARG ASN ALA ALA HIS GLY ALA
SEQRES 83 B 1784 LEU TRP GLY VAL GLY ARG VAL ILE ALA LEU GLU ASN PRO
SEQRES 84 B 1784 ALA VAL TRP GLY GLY LEU VAL ASP VAL PRO ALA GLY SER
SEQRES 85 B 1784 VAL ALA GLU LEU ALA ARG HIS LEU ALA ALA VAL VAL SER
SEQRES 86 B 1784 GLY GLY ALA GLY GLU ASP GLN LEU ALA LEU ARG ALA ASP
SEQRES 87 B 1784 GLY VAL TYR GLY ARG ARG TRP VAL ARG ALA ALA ALA PRO
SEQRES 88 B 1784 ALA THR ASP ASP GLU TRP LYS PRO THR GLY THR VAL LEU
SEQRES 89 B 1784 VAL THR GLY GLY THR GLY GLY VAL GLY GLY GLN ILE ALA
SEQRES 90 B 1784 ARG TRP LEU ALA ARG ARG GLY ALA PRO HIS LEU LEU LEU
SEQRES 91 B 1784 VAL SER ARG SER GLY PRO ASP ALA ASP GLY ALA GLY GLU
SEQRES 92 B 1784 LEU VAL ALA GLU LEU GLU ALA LEU GLY ALA ARG THR THR
SEQRES 93 B 1784 VAL ALA ALA CYS ASP VAL THR ASP ARG GLU SER VAL ARG
SEQRES 94 B 1784 GLU LEU LEU GLY GLY ILE GLY ASP ASP VAL PRO LEU SER
SEQRES 95 B 1784 ALA VAL PHE HIS ALA ALA ALA THR LEU ASP ASP GLY THR
SEQRES 96 B 1784 VAL ASP THR LEU THR GLY GLU ARG ILE GLU ARG ALA SER
SEQRES 97 B 1784 ARG ALA LYS VAL LEU GLY ALA ARG ASN LEU HIS GLU LEU
SEQRES 98 B 1784 THR ARG GLU LEU ASP LEU THR ALA PHE VAL LEU PHE SER
SEQRES 99 B 1784 SER PHE ALA SER ALA PHE GLY ALA PRO GLY LEU GLY GLY
SEQRES 100 B 1784 TYR ALA PRO GLY ASN ALA TYR LEU ASP GLY LEU ALA GLN
SEQRES 101 B 1784 GLN ARG ARG SER ASP GLY LEU PRO ALA THR ALA VAL ALA
SEQRES 102 B 1784 TRP GLY THR TRP ALA GLY SER GLY MET ALA GLU GLY PRO
SEQRES 103 B 1784 VAL ALA ASP ARG PHE ARG ARG HIS GLY VAL ILE GLU MET
SEQRES 104 B 1784 PRO PRO GLU THR ALA CYS ARG ALA LEU GLN ASN ALA LEU
SEQRES 105 B 1784 ASP ARG ALA GLU VAL CYS PRO ILE VAL ILE ASP VAL ARG
SEQRES 106 B 1784 TRP ASP ARG PHE LEU LEU ALA TYR THR ALA GLN ARG PRO
SEQRES 107 B 1784 THR ARG LEU PHE ASP GLU ILE ASP ASP ALA ARG ARG ALA
SEQRES 108 B 1784 ALA PRO GLN ALA ALA ALA GLU PRO ARG VAL GLY ALA LEU
SEQRES 109 B 1784 ALA SER LEU PRO ALA PRO GLU ARG GLU LYS ALA LEU PHE
SEQRES 110 B 1784 GLU LEU VAL ARG SER HIS ALA ALA ALA VAL LEU GLY HIS
SEQRES 111 B 1784 ALA SER ALA GLU ARG VAL PRO ALA ASP GLN ALA PHE ALA
SEQRES 112 B 1784 GLU LEU GLY VAL ASP SER LEU SER ALA LEU GLU LEU ARG
SEQRES 113 B 1784 ASN ARG LEU GLY ALA ALA THR GLY VAL ARG LEU PRO THR
SEQRES 114 B 1784 THR THR VAL PHE ASP HIS PRO ASP VAL ARG THR LEU ALA
SEQRES 115 B 1784 ALA HIS LEU THR SER GLU LEU GLY SER GLY THR PRO ALA
SEQRES 116 B 1784 ARG GLU ALA SER SER ALA LEU ARG ASP GLY TYR ARG GLN
SEQRES 117 B 1784 ALA GLY VAL SER GLY ARG VAL ARG SER TYR LEU ASP LEU
SEQRES 118 B 1784 LEU ALA GLY LEU SER ASP PHE ARG GLU HIS PHE ASP GLY
SEQRES 119 B 1784 SER ASP GLY PHE SER LEU ASP LEU VAL ASP MET ALA ASP
SEQRES 120 B 1784 GLY PRO GLY GLU VAL THR VAL ILE CYS CYS ALA GLY THR
SEQRES 121 B 1784 ALA ALA ILE SER GLY PRO HIS GLU PHE THR ARG LEU ALA
SEQRES 122 B 1784 GLY ALA LEU ARG GLY ILE ALA PRO VAL ARG ALA VAL PRO
SEQRES 123 B 1784 GLN PRO GLY TYR GLU GLU GLY GLU PRO LEU PRO SER SER
SEQRES 124 B 1784 MET ALA ALA VAL ALA ALA VAL GLN ALA ASP ALA VAL ILE
SEQRES 125 B 1784 ARG THR GLN GLY ASP LYS PRO PHE VAL VAL ALA GLY HIS
SEQRES 126 B 1784 SER ALA GLY ALA LEU MET ALA TYR ALA LEU ALA THR GLU
SEQRES 127 B 1784 LEU LEU ASP ARG GLY HIS PRO PRO ARG GLY VAL VAL LEU
SEQRES 128 B 1784 ILE ASP VAL TYR PRO PRO GLY HIS GLN ASP ALA MET ASN
SEQRES 129 B 1784 ALA TRP LEU GLU GLU LEU THR ALA THR LEU PHE ASP ARG
SEQRES 130 B 1784 GLU THR VAL ARG MET ASP ASP THR ARG LEU THR ALA LEU
SEQRES 131 B 1784 GLY ALA TYR ASP ARG LEU THR GLY GLN TRP ARG PRO ARG
SEQRES 132 B 1784 GLU THR GLY LEU PRO THR LEU LEU VAL SER ALA GLY GLU
SEQRES 133 B 1784 PRO MET GLY PRO TRP PRO ASP ASP SER TRP LYS PRO THR
SEQRES 134 B 1784 TRP PRO PHE GLU HIS ASP THR VAL ALA VAL PRO GLY ASP
SEQRES 135 B 1784 HIS PHE THR MET VAL GLN GLU HIS ALA ASP ALA ILE ALA
SEQRES 136 B 1784 ARG HIS ILE ASP ALA TRP LEU GLY GLY GLY ASN SER SER
SEQRES 137 B 1784 SER VAL ASP LYS LEU ALA ALA ALA LEU GLU HIS HIS HIS
SEQRES 138 B 1784 HIS HIS HIS
SEQRES 1 C 249 MET ALA GLU VAL GLN LEU VAL GLN SER GLY GLY GLY LEU
SEQRES 2 C 249 VAL GLN PRO GLY ARG SER LEU ARG LEU SER CYS THR ALA
SEQRES 3 C 249 SER GLY PHE THR PHE GLY ASP TYR ALA MET SER TRP VAL
SEQRES 4 C 249 ARG GLN ALA PRO GLY LYS GLY LEU GLU TRP VAL GLY PHE
SEQRES 5 C 249 ILE ARG SER LYS ALA TYR GLY GLY THR THR GLU TYR ALA
SEQRES 6 C 249 ALA SER VAL LYS GLY ARG PHE THR ILE SER ARG ASP ASP
SEQRES 7 C 249 SER LYS SER ILE ALA TYR LEU GLN MET ASN SER LEU LYS
SEQRES 8 C 249 THR GLU ASP THR ALA VAL TYR TYR CYS THR ARG GLY GLY
SEQRES 9 C 249 THR LEU PHE ASP TYR TRP GLY GLN GLY THR LEU VAL THR
SEQRES 10 C 249 VAL SER SER ALA SER THR LYS GLY PRO SER VAL PHE PRO
SEQRES 11 C 249 LEU ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA
SEQRES 12 C 249 ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO
SEQRES 13 C 249 VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY
SEQRES 14 C 249 VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU
SEQRES 15 C 249 TYR SER LEU SER SER VAL VAL THR VAL PRO SER SER SER
SEQRES 16 C 249 LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS
SEQRES 17 C 249 PRO SER ASN THR LYS VAL ASP LYS LYS VAL GLU PRO LYS
SEQRES 18 C 249 SER CYS ALA ALA LEU VAL PRO ARG GLY SER ALA HIS HIS
SEQRES 19 C 249 HIS HIS HIS HIS ALA ALA ASP TYR LYS ASP ASP ASP ASP
SEQRES 20 C 249 LYS ALA
SEQRES 1 D 236 LEU PHE ALA ILE PRO LEU VAL VAL PRO PHE TYR SER HIS
SEQRES 2 D 236 SER ALA LEU ASP VAL VAL MET THR GLN SER PRO LEU SER
SEQRES 3 D 236 LEU PRO VAL THR PRO GLY GLU PRO ALA SER ILE SER CYS
SEQRES 4 D 236 ARG SER SER GLN SER LEU LEU HIS SER ASN GLY TYR ASN
SEQRES 5 D 236 TYR LEU ASP TRP TYR LEU GLN LYS PRO GLY GLN SER PRO
SEQRES 6 D 236 GLN LEU LEU ILE TYR LEU GLY SER ASN ARG ALA SER GLY
SEQRES 7 D 236 VAL PRO ASP ARG PHE SER GLY SER GLY SER GLY THR ASP
SEQRES 8 D 236 PHE THR LEU LYS ILE SER ARG VAL GLU ALA GLU ASP VAL
SEQRES 9 D 236 GLY VAL TYR TYR CYS MET GLN SER LEU GLN THR PRO ARG
SEQRES 10 D 236 LEU THR PHE GLY PRO GLY THR LYS VAL ASP ILE LYS ARG
SEQRES 11 D 236 THR VAL ALA ALA PRO SER VAL PHE ILE PHE PRO PRO SER
SEQRES 12 D 236 ASP GLU GLN LEU LYS SER GLY THR ALA SER VAL VAL CYS
SEQRES 13 D 236 LEU LEU ASN ASN PHE TYR PRO ARG GLY ALA LYS VAL GLN
SEQRES 14 D 236 TRP LYS VAL ASP ASN ALA LEU GLN SER GLY ASN SER GLN
SEQRES 15 D 236 GLU SER VAL THR GLU GLN ASP SER LYS ASP SER THR TYR
SEQRES 16 D 236 SER LEU SER SER THR LEU THR LEU SER LYS ALA ASP TYR
SEQRES 17 D 236 GLU LYS HIS LYS VAL TYR ALA CYS GLU VAL THR HIS GLN
SEQRES 18 D 236 GLY LEU SER SER PRO VAL THR LYS SER PHE ASN ARG GLY
SEQRES 19 D 236 GLU CYS
SEQRES 1 E 249 MET ALA GLU VAL GLN LEU VAL GLN SER GLY GLY GLY LEU
SEQRES 2 E 249 VAL GLN PRO GLY ARG SER LEU ARG LEU SER CYS THR ALA
SEQRES 3 E 249 SER GLY PHE THR PHE GLY ASP TYR ALA MET SER TRP VAL
SEQRES 4 E 249 ARG GLN ALA PRO GLY LYS GLY LEU GLU TRP VAL GLY PHE
SEQRES 5 E 249 ILE ARG SER LYS ALA TYR GLY GLY THR THR GLU TYR ALA
SEQRES 6 E 249 ALA SER VAL LYS GLY ARG PHE THR ILE SER ARG ASP ASP
SEQRES 7 E 249 SER LYS SER ILE ALA TYR LEU GLN MET ASN SER LEU LYS
SEQRES 8 E 249 THR GLU ASP THR ALA VAL TYR TYR CYS THR ARG GLY GLY
SEQRES 9 E 249 THR LEU PHE ASP TYR TRP GLY GLN GLY THR LEU VAL THR
SEQRES 10 E 249 VAL SER SER ALA SER THR LYS GLY PRO SER VAL PHE PRO
SEQRES 11 E 249 LEU ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA
SEQRES 12 E 249 ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO
SEQRES 13 E 249 VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY
SEQRES 14 E 249 VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU
SEQRES 15 E 249 TYR SER LEU SER SER VAL VAL THR VAL PRO SER SER SER
SEQRES 16 E 249 LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS
SEQRES 17 E 249 PRO SER ASN THR LYS VAL ASP LYS LYS VAL GLU PRO LYS
SEQRES 18 E 249 SER CYS ALA ALA LEU VAL PRO ARG GLY SER ALA HIS HIS
SEQRES 19 E 249 HIS HIS HIS HIS ALA ALA ASP TYR LYS ASP ASP ASP ASP
SEQRES 20 E 249 LYS ALA
SEQRES 1 F 236 LEU PHE ALA ILE PRO LEU VAL VAL PRO PHE TYR SER HIS
SEQRES 2 F 236 SER ALA LEU ASP VAL VAL MET THR GLN SER PRO LEU SER
SEQRES 3 F 236 LEU PRO VAL THR PRO GLY GLU PRO ALA SER ILE SER CYS
SEQRES 4 F 236 ARG SER SER GLN SER LEU LEU HIS SER ASN GLY TYR ASN
SEQRES 5 F 236 TYR LEU ASP TRP TYR LEU GLN LYS PRO GLY GLN SER PRO
SEQRES 6 F 236 GLN LEU LEU ILE TYR LEU GLY SER ASN ARG ALA SER GLY
SEQRES 7 F 236 VAL PRO ASP ARG PHE SER GLY SER GLY SER GLY THR ASP
SEQRES 8 F 236 PHE THR LEU LYS ILE SER ARG VAL GLU ALA GLU ASP VAL
SEQRES 9 F 236 GLY VAL TYR TYR CYS MET GLN SER LEU GLN THR PRO ARG
SEQRES 10 F 236 LEU THR PHE GLY PRO GLY THR LYS VAL ASP ILE LYS ARG
SEQRES 11 F 236 THR VAL ALA ALA PRO SER VAL PHE ILE PHE PRO PRO SER
SEQRES 12 F 236 ASP GLU GLN LEU LYS SER GLY THR ALA SER VAL VAL CYS
SEQRES 13 F 236 LEU LEU ASN ASN PHE TYR PRO ARG GLY ALA LYS VAL GLN
SEQRES 14 F 236 TRP LYS VAL ASP ASN ALA LEU GLN SER GLY ASN SER GLN
SEQRES 15 F 236 GLU SER VAL THR GLU GLN ASP SER LYS ASP SER THR TYR
SEQRES 16 F 236 SER LEU SER SER THR LEU THR LEU SER LYS ALA ASP TYR
SEQRES 17 F 236 GLU LYS HIS LYS VAL TYR ALA CYS GLU VAL THR HIS GLN
SEQRES 18 F 236 GLY LEU SER SER PRO VAL THR LYS SER PHE ASN ARG GLY
SEQRES 19 F 236 GLU CYS
HELIX 1 AA1 TYR A 12 THR A 17 1 6
HELIX 2 AA2 ASP A 19 ARG A 24 1 6
HELIX 3 AA3 ARG A 26 GLU A 31 1 6
HELIX 4 AA4 THR A 50 SER A 59 1 10
HELIX 5 AA5 SER A 112 VAL A 119 1 8
HELIX 6 AA6 ASP A 120 ARG A 136 1 17
HELIX 7 AA7 ARG A 163 GLY A 167 5 5
HELIX 8 AA8 TYR A 174 THR A 179 1 6
HELIX 9 AA9 SER A 182 LEU A 192 1 11
HELIX 10 AB1 THR A 203 CYS A 205 5 3
HELIX 11 AB2 SER A 206 ARG A 221 1 16
HELIX 12 AB3 PRO A 238 PHE A 244 1 7
HELIX 13 AB4 LEU A 280 ASN A 286 1 7
HELIX 14 AB5 ASN A 312 GLY A 328 1 17
HELIX 15 AB6 GLY A 330 ILE A 334 5 5
HELIX 16 AB7 LEU A 346 TYR A 359 1 14
HELIX 17 AB8 GLY A 360 ARG A 363 5 4
HELIX 18 AB9 SER A 371 GLY A 377 1 7
HELIX 19 AC1 THR A 379 ALA A 383 5 5
HELIX 20 AC2 GLY A 384 GLY A 398 1 15
HELIX 21 AC3 SER A 481 ARG A 486 1 6
HELIX 22 AC4 ALA A 489 HIS A 499 1 11
HELIX 23 AC5 ASP A 503 THR A 513 1 11
HELIX 24 AC6 ASP A 528 LEU A 536 1 9
HELIX 25 AC7 ALA A 573 ASP A 578 1 6
HELIX 26 AC8 SER A 580 ALA A 593 1 14
HELIX 27 AC9 VAL A 602 ARG A 607 1 6
HELIX 28 AD1 ARG A 623 TRP A 642 1 20
HELIX 29 AD2 GLN A 657 ALA A 666 1 10
HELIX 30 AD3 ARG A 676 MET A 688 1 13
HELIX 31 AD4 PRO A 700 ARG A 705 1 6
HELIX 32 AD5 GLU A 731 THR A 741 1 11
HELIX 33 AD6 HIS A 759 ILE A 763 5 5
HELIX 34 AD7 GLY A 801 ARG A 808 1 8
HELIX 35 AD8 ARG A 812 GLU A 822 1 11
HELIX 36 AD9 LEU A 837 GLY A 847 1 11
HELIX 37 AE1 LEU A 865 GLY A 879 1 15
HELIX 38 AE2 ASP A 883 HIS A 888 1 6
HELIX 39 AE3 VAL A 915 THR A 920 1 6
HELIX 40 AE4 ASP A 959 GLU A 967 1 9
HELIX 41 AE5 ASP A 988 GLY A 998 1 11
HELIX 42 AE6 ALA A 1017 ALA A 1020 5 4
HELIX 43 AE7 LEU A 1021 GLU A 1038 1 18
HELIX 44 AE8 ASN A 1061 ASN A 1078 1 18
HELIX 45 AE9 VAL A 1093 SER A 1105 1 13
HELIX 46 AF1 GLY A 1150 GLY A 1153 5 4
HELIX 47 AF2 GLY A 1154 GLY A 1164 1 11
HELIX 48 AF3 SER A 1174 ALA A 1178 5 5
HELIX 49 AF4 GLY A 1180 GLY A 1192 1 13
HELIX 50 AF5 ASP A 1204 ILE A 1215 1 12
HELIX 51 AF6 THR A 1240 SER A 1248 1 9
HELIX 52 AF7 SER A 1248 ARG A 1263 1 16
HELIX 53 AF8 TYR A 1288 ARG A 1303 1 16
HELIX 54 AF9 GLY A 1325 ARG A 1333 1 9
HELIX 55 AG1 PRO A 1340 ARG A 1354 1 15
HELIX 56 AG2 ARG A 1365 THR A 1374 1 10
HELIX 57 AG3 THR A 1379 ASP A 1383 5 5
HELIX 58 AG4 ILE A 1385 ARG A 1389 5 5
HELIX 59 AG5 LYS B 8 ARG B 21 1 14
HELIX 60 AG6 THR B 50 SER B 59 1 10
HELIX 61 AG7 ASP B 75 PHE B 80 1 6
HELIX 62 AG8 GLU B 115 VAL B 119 5 5
HELIX 63 AG9 ASP B 120 ARG B 136 1 17
HELIX 64 AH1 GLU B 172 MET B 176 5 5
HELIX 65 AH2 THR B 181 LEU B 192 1 12
HELIX 66 AH3 THR B 203 CYS B 205 5 3
HELIX 67 AH4 SER B 206 ARG B 220 1 15
HELIX 68 AH5 ASP B 243 ASN B 248 5 6
HELIX 69 AH6 GLY B 347 ALA B 354 1 8
HELIX 70 AH7 SER B 371 LEU B 376 1 6
HELIX 71 AH8 THR B 379 ALA B 383 5 5
HELIX 72 AH9 ILE B 389 ALA B 394 1 6
HELIX 73 AI1 SER B 481 ALA B 489 1 9
HELIX 74 AI2 ALA B 493 GLU B 498 1 6
HELIX 75 AI3 ASP B 503 ALA B 508 1 6
HELIX 76 AI4 ASP B 528 THR B 541 1 14
HELIX 77 AI5 ASP B 575 SER B 580 1 6
HELIX 78 AI6 SER B 580 GLU B 595 1 16
HELIX 79 AI7 PRO B 596 LEU B 598 5 3
HELIX 80 AI8 VAL B 602 ALA B 608 1 7
HELIX 81 AI9 GLU B 609 GLU B 614 1 6
HELIX 82 AJ1 ARG B 623 HIS B 645 1 23
HELIX 83 AJ2 GLN B 657 GLY B 667 1 11
HELIX 84 AJ3 SER B 670 ALA B 686 1 17
HELIX 85 AJ4 PRO B 700 ILE B 708 1 9
HELIX 86 AJ5 GLU B 731 GLU B 742 1 12
HELIX 87 AJ6 GLY B 801 LEU B 807 1 7
HELIX 88 AJ7 ARG B 812 GLN B 823 1 12
HELIX 89 AJ8 ILE B 836 GLY B 845 1 10
HELIX 90 AJ9 SER B 864 GLY B 879 1 16
HELIX 91 AK1 ASP B 883 HIS B 888 1 6
HELIX 92 AK2 ASP B 959 GLU B 967 1 9
HELIX 93 AK3 ASP B 988 GLY B 998 1 11
HELIX 94 AK4 LEU B 1021 GLU B 1038 1 18
HELIX 95 AK5 ASN B 1061 ASN B 1078 1 18
HELIX 96 AK6 VAL B 1093 SER B 1105 1 13
HELIX 97 AK7 GLY B 1150 GLY B 1153 5 4
HELIX 98 AK8 GLY B 1154 GLY B 1164 1 11
HELIX 99 AK9 SER B 1174 ALA B 1178 5 5
HELIX 100 AL1 GLY B 1180 GLY B 1192 1 13
HELIX 101 AL2 ASP B 1204 ILE B 1215 1 12
HELIX 102 AL3 THR B 1240 SER B 1248 1 9
HELIX 103 AL4 SER B 1248 THR B 1262 1 15
HELIX 104 AL5 TYR B 1288 SER B 1304 1 17
HELIX 105 AL6 GLY B 1325 ARG B 1333 1 9
HELIX 106 AL7 PRO B 1340 ARG B 1354 1 15
HELIX 107 AL8 ARG B 1365 THR B 1374 1 10
HELIX 108 AL9 THR B 1379 ASP B 1383 5 5
HELIX 109 AM1 ILE B 1385 ARG B 1389 5 5
HELIX 110 AM2 SER C 55 GLY C 59 5 5
HELIX 111 AM3 LYS C 91 THR C 95 5 5
HELIX 112 AM4 SER D 143 GLY D 150 1 8
HELIX 113 AM5 LYS D 205 GLU D 209 5 5
HELIX 114 AM6 LYS E 91 THR E 95 5 5
HELIX 115 AM7 SER F 143 LYS F 148 1 6
HELIX 116 AM8 LYS F 205 GLU F 209 5 5
SHEET 1 AA120 ALA A 336 GLU A 338 0
SHEET 2 AA120 ARG A 437 PHE A 443 1 O GLY A 439 N GLU A 338
SHEET 3 AA120 THR A 448 GLU A 456 -1 O ALA A 450 N SER A 442
SHEET 4 AA120 ALA A 292 SER A 301 -1 N ASN A 300 O ASN A 449
SHEET 5 AA120 VAL A 35 ARG A 43 -1 N VAL A 37 O ALA A 292
SHEET 6 AA120 GLY A 271 ARG A 279 -1 O GLU A 278 N ALA A 36
SHEET 7 AA120 LEU A 226 THR A 233 -1 N THR A 233 O GLY A 271
SHEET 8 AA120 THR A 149 GLY A 154 1 N PHE A 152 O MET A 228
SHEET 9 AA120 ALA A 198 ASP A 202 1 O VAL A 201 N VAL A 153
SHEET 10 AA120 ILE B 199 ASP B 202 -1 O ASP B 202 N SER A 200
SHEET 11 AA120 THR B 149 GLY B 154 1 N VAL B 153 O ILE B 199
SHEET 12 AA120 LEU B 226 GLY B 231 1 O MET B 228 N PHE B 152
SHEET 13 AA120 MET B 274 ARG B 279 -1 O LEU B 277 N ALA B 227
SHEET 14 AA120 VAL B 35 ALA B 41 -1 N VAL B 38 O LEU B 276
SHEET 15 AA120 ALA B 292 SER B 301 -1 O ALA B 292 N VAL B 37
SHEET 16 AA120 THR B 448 GLU B 456 -1 O ASN B 449 N ASN B 300
SHEET 17 AA120 ARG B 437 SER B 442 -1 N VAL B 440 O ALA B 452
SHEET 18 AA120 ILE B 334 GLU B 338 1 N GLU B 338 O GLY B 439
SHEET 19 AA120 LEU B 367 GLY B 370 1 O GLY B 370 N VAL B 337
SHEET 20 AA120 ILE B 420 LEU B 422 1 O SER B 421 N LEU B 367
SHEET 1 AA2 2 ALA A 103 PHE A 104 0
SHEET 2 AA2 2 GLU A 906 ARG A 907 -1 O GLU A 906 N PHE A 104
SHEET 1 AA3 2 LEU A 367 LEU A 369 0
SHEET 2 AA3 2 ILE A 420 LEU A 422 1 O SER A 421 N LEU A 367
SHEET 1 AA4 2 THR A 399 LEU A 400 0
SHEET 2 AA4 2 GLU A 427 PRO A 428 -1 O GLU A 427 N LEU A 400
SHEET 1 AA5 2 TRP A 475 SER A 478 0
SHEET 2 AA5 2 ARG A 521 PHE A 524 -1 O PHE A 524 N TRP A 475
SHEET 1 AA6 2 VAL A 559 PHE A 560 0
SHEET 2 AA6 2 PHE A 828 LEU A 829 1 N LEU A 829 O VAL A 559
SHEET 1 AA7 3 GLY A 693 ALA A 695 0
SHEET 2 AA7 3 VAL A 724 GLY A 727 -1 O VAL A 725 N ALA A 695
SHEET 3 AA7 3 ILE A 714 ALA A 716 -1 N ALA A 716 O VAL A 724
SHEET 1 AA8 8 ARG A 935 PRO A 936 0
SHEET 2 AA8 8 GLY A1119 GLY A1122 -1 O GLY A1122 N ARG A 935
SHEET 3 AA8 8 GLN A1112 ARG A1116 -1 N ARG A1116 O GLY A1119
SHEET 4 AA8 8 TRP A1082 VAL A1088 1 N ASP A1087 O LEU A1113
SHEET 5 AA8 8 LEU A1043 GLU A1048 1 N THR A1047 O VAL A1088
SHEET 6 AA8 8 GLY A1002 ALA A1008 1 N SER A1005 O TRP A1044
SHEET 7 AA8 8 THR A 948 LYS A 953 1 N LEU A 950 O LEU A1004
SHEET 8 AA8 8 ARG A 975 VAL A 980 1 O ARG A 975 N TRP A 949
SHEET 1 AA9 2 VAL A1145 THR A1146 0
SHEET 2 AA9 2 PHE A1225 HIS A1226 1 N PHE A1225 O THR A1146
SHEET 1 AB1 2 LEU A1168 SER A1172 0
SHEET 2 AB1 2 THR A1195 ALA A1199 1 O ALA A1198 N LEU A1170
SHEET 1 AB2 3 LEU A1272 SER A1275 0
SHEET 2 AB2 3 ALA A1311 TRP A1314 1 O TRP A1314 N SER A1274
SHEET 3 AB2 3 ILE A1360 VAL A1361 1 O VAL A1361 N ALA A1313
SHEET 1 AB3 2 VAL A1336 ILE A1337 0
SHEET 2 AB3 2 ASP A1363 VAL A1364 -1 O ASP A1363 N ILE A1337
SHEET 1 AB4 2 THR B 399 LEU B 400 0
SHEET 2 AB4 2 GLU B 427 PRO B 428 -1 O GLU B 427 N LEU B 400
SHEET 1 AB5 3 SER B 478 ALA B 479 0
SHEET 2 AB5 3 HIS B 520 ALA B 523 -1 O HIS B 520 N ALA B 479
SHEET 3 AB5 3 ALA B 548 GLY B 550 -1 O ALA B 548 N ALA B 523
SHEET 1 AB6 3 PRO B 649 GLY B 654 0
SHEET 2 AB6 3 ALA B 558 PHE B 562 1 N ALA B 558 O ALA B 650
SHEET 3 AB6 3 PHE B 828 GLU B 830 1 O LEU B 829 N VAL B 559
SHEET 1 AB7 4 VAL B 712 GLY B 719 0
SHEET 2 AB7 4 SER B 722 GLY B 727 -1 O VAL B 724 N ALA B 716
SHEET 3 AB7 4 ALA B 695 ILE B 697 -1 N ALA B 695 O VAL B 725
SHEET 4 AB7 4 ALA B 746 ARG B 748 -1 O LYS B 747 N SER B 696
SHEET 1 AB8 8 ARG B 935 PRO B 936 0
SHEET 2 AB8 8 GLY B1119 GLY B1122 -1 O GLY B1122 N ARG B 935
SHEET 3 AB8 8 GLN B1112 ARG B1116 -1 N ARG B1116 O GLY B1119
SHEET 4 AB8 8 TRP B1082 VAL B1088 1 N ASP B1087 O LEU B1113
SHEET 5 AB8 8 LEU B1043 GLU B1048 1 N THR B1047 O VAL B1088
SHEET 6 AB8 8 GLY B1002 ALA B1008 1 N SER B1005 O TRP B1044
SHEET 7 AB8 8 THR B 948 LYS B 953 1 N LEU B 950 O LEU B1004
SHEET 8 AB8 8 ARG B 975 VAL B 980 1 O ARG B 975 N TRP B 949
SHEET 1 AB9 2 VAL B1145 THR B1146 0
SHEET 2 AB9 2 PHE B1225 HIS B1226 1 N PHE B1225 O THR B1146
SHEET 1 AC1 2 LEU B1170 SER B1172 0
SHEET 2 AC1 2 VAL B1197 ALA B1199 1 O ALA B1198 N LEU B1170
SHEET 1 AC2 3 VAL B1271 SER B1275 0
SHEET 2 AC2 3 THR B1310 TRP B1314 1 O TRP B1314 N SER B1274
SHEET 3 AC2 3 ILE B1360 VAL B1361 1 O VAL B1361 N ALA B1313
SHEET 1 AC3 2 VAL B1336 ILE B1337 0
SHEET 2 AC3 2 ASP B1363 VAL B1364 -1 O ASP B1363 N ILE B1337
SHEET 1 AC4 4 GLN C 5 SER C 9 0
SHEET 2 AC4 4 SER C 19 SER C 27 -1 O THR C 25 N VAL C 7
SHEET 3 AC4 4 ILE C 82 ASN C 88 -1 O MET C 87 N LEU C 20
SHEET 4 AC4 4 PHE C 72 ASP C 77 -1 N THR C 73 O GLN C 86
SHEET 1 AC5 3 GLY C 12 VAL C 14 0
SHEET 2 AC5 3 THR C 114 VAL C 118 1 O THR C 117 N GLY C 12
SHEET 3 AC5 3 ALA C 96 TYR C 98 -1 N ALA C 96 O VAL C 116
SHEET 1 AC6 3 SER C 37 ARG C 40 0
SHEET 2 AC6 3 GLU C 48 ILE C 53 -1 O GLU C 48 N ARG C 40
SHEET 3 AC6 3 THR C 62 TYR C 64 -1 O GLU C 63 N PHE C 52
SHEET 1 AC7 4 PRO C 130 LEU C 131 0
SHEET 2 AC7 4 ALA C 144 LEU C 148 -1 O GLY C 146 N LEU C 131
SHEET 3 AC7 4 SER C 186 THR C 190 -1 O VAL C 189 N LEU C 145
SHEET 4 AC7 4 HIS C 171 THR C 172 -1 N HIS C 171 O VAL C 188
SHEET 1 AC8 3 VAL C 159 TRP C 161 0
SHEET 2 AC8 3 TYR C 201 HIS C 207 -1 O ASN C 204 N SER C 160
SHEET 3 AC8 3 THR C 212 VAL C 218 -1 O VAL C 214 N VAL C 205
SHEET 1 AC9 4 THR D 21 GLN D 22 0
SHEET 2 AC9 4 ALA D 35 SER D 41 -1 O ARG D 40 N GLN D 22
SHEET 3 AC9 4 ASP D 91 ILE D 96 -1 O LEU D 94 N ILE D 37
SHEET 4 AC9 4 PHE D 83 GLY D 87 -1 N SER D 86 O THR D 93
SHEET 1 AD1 2 PRO D 28 VAL D 29 0
SHEET 2 AD1 2 ASP D 127 ILE D 128 1 O ASP D 127 N VAL D 29
SHEET 1 AD2 5 ASN D 74 ARG D 75 0
SHEET 2 AD2 5 PRO D 65 TYR D 70 -1 N TYR D 70 O ASN D 74
SHEET 3 AD2 5 LEU D 54 GLN D 59 -1 N LEU D 58 O GLN D 66
SHEET 4 AD2 5 VAL D 106 GLN D 111 -1 O MET D 110 N ASP D 55
SHEET 5 AD2 5 THR D 124 LYS D 125 -1 O THR D 124 N TYR D 107
SHEET 1 AD3 3 PHE D 138 PHE D 140 0
SHEET 2 AD3 3 ALA D 152 PHE D 161 -1 O VAL D 155 N PHE D 140
SHEET 3 AD3 3 TYR D 195 LEU D 203 -1 O TYR D 195 N PHE D 161
SHEET 1 AD4 2 VAL D 168 TRP D 170 0
SHEET 2 AD4 2 CYS D 216 VAL D 218 -1 O GLU D 217 N GLN D 169
SHEET 1 AD5 4 GLN E 5 SER E 9 0
SHEET 2 AD5 4 LEU E 20 SER E 27 -1 O THR E 25 N VAL E 7
SHEET 3 AD5 4 ILE E 82 MET E 87 -1 O MET E 87 N LEU E 20
SHEET 4 AD5 4 PHE E 72 ASP E 77 -1 N THR E 73 O GLN E 86
SHEET 1 AD6 3 LEU E 13 VAL E 14 0
SHEET 2 AD6 3 THR E 114 VAL E 118 1 O THR E 117 N VAL E 14
SHEET 3 AD6 3 ALA E 96 TYR E 98 -1 N ALA E 96 O VAL E 116
SHEET 1 AD7 3 MET E 36 GLN E 41 0
SHEET 2 AD7 3 LEU E 47 ILE E 53 -1 O GLY E 51 N TRP E 38
SHEET 3 AD7 3 THR E 62 TYR E 64 -1 O GLU E 63 N PHE E 52
SHEET 1 AD8 3 PRO E 130 LEU E 131 0
SHEET 2 AD8 3 ALA E 144 LEU E 148 -1 O GLY E 146 N LEU E 131
SHEET 3 AD8 3 SER E 186 THR E 190 -1 O VAL E 189 N LEU E 145
SHEET 1 AD9 3 VAL E 159 TRP E 161 0
SHEET 2 AD9 3 TYR E 201 ASN E 206 -1 O ASN E 204 N SER E 160
SHEET 3 AD9 3 LYS E 213 VAL E 218 -1 O LYS E 216 N CYS E 203
SHEET 1 AE1 2 VAL E 176 LEU E 177 0
SHEET 2 AE1 2 TYR E 183 SER E 184 -1 O SER E 184 N VAL E 176
SHEET 1 AE2 4 THR F 21 GLN F 22 0
SHEET 2 AE2 4 ALA F 35 SER F 41 -1 O ARG F 40 N GLN F 22
SHEET 3 AE2 4 ASP F 91 ILE F 96 -1 O PHE F 92 N CYS F 39
SHEET 4 AE2 4 PHE F 83 GLY F 87 -1 N SER F 84 O LYS F 95
SHEET 1 AE3 6 PRO F 28 VAL F 29 0
SHEET 2 AE3 6 THR F 124 ILE F 128 1 O ASP F 127 N VAL F 29
SHEET 3 AE3 6 GLY F 105 GLN F 111 -1 N GLY F 105 O VAL F 126
SHEET 4 AE3 6 LEU F 54 GLN F 59 -1 N ASP F 55 O MET F 110
SHEET 5 AE3 6 GLN F 66 TYR F 70 -1 O ILE F 69 N TRP F 56
SHEET 6 AE3 6 ASN F 74 ARG F 75 -1 O ASN F 74 N TYR F 70
SHEET 1 AE4 2 LEU F 46 HIS F 47 0
SHEET 2 AE4 2 TYR F 51 ASN F 52 -1 O TYR F 51 N HIS F 47
SHEET 1 AE5 4 SER F 136 PHE F 140 0
SHEET 2 AE5 4 VAL F 155 PHE F 161 -1 O ASN F 159 N SER F 136
SHEET 3 AE5 4 TYR F 195 THR F 200 -1 O TYR F 195 N PHE F 161
SHEET 4 AE5 4 VAL F 185 THR F 186 -1 N THR F 186 O SER F 196
SHEET 1 AE6 2 VAL F 168 TRP F 170 0
SHEET 2 AE6 2 CYS F 216 VAL F 218 -1 O GLU F 217 N GLN F 169
SSBOND 1 CYS C 24 CYS C 100 1555 1555 2.00
SSBOND 2 CYS C 147 CYS C 203 1555 1555 2.04
SSBOND 3 CYS D 39 CYS D 109 1555 1555 2.03
SSBOND 4 CYS D 156 CYS D 216 1555 1555 2.03
SSBOND 5 CYS E 24 CYS E 100 1555 1555 2.06
SSBOND 6 CYS E 147 CYS E 203 1555 1555 2.04
SSBOND 7 CYS F 39 CYS F 109 1555 1555 2.03
SSBOND 8 CYS F 156 CYS F 216 1555 1555 2.03
CISPEP 1 PHE C 153 PRO C 154 0 -2.45
CISPEP 2 THR D 115 PRO D 116 0 28.67
CISPEP 3 TYR D 162 PRO D 163 0 1.61
CISPEP 4 PHE E 153 PRO E 154 0 -2.18
CISPEP 5 TYR F 162 PRO F 163 0 1.76
CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1
ORIGX1 1.000000 0.000000 0.000000 0.00000
ORIGX2 0.000000 1.000000 0.000000 0.00000
ORIGX3 0.000000 0.000000 1.000000 0.00000
SCALE1 1.000000 0.000000 0.000000 0.00000
SCALE2 0.000000 1.000000 0.000000 0.00000
SCALE3 0.000000 0.000000 1.000000 0.00000
TER 10047 ARG A1390
TER 20268 ARG B1390
TER 21808 PRO C 220
TER 23377 PHE D 231
TER 24917 PRO E 220
TER 26486 PHE F 231
MASTER 1324 0 0 116 148 0 0 626480 6 16 354
END |