longtext: 7nfz-pdb

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HEADER    HYDROLASE                               08-FEB-21   7NFZ
TITLE     CRYSTAL STRUCTURE OF HALOALKANE DEHALOGENASE LINB57 MUTANT (H272F)
TITLE    2 FROM SPHINGOBIUM JAPONICUM UT26
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: HALOALKANE DEHALOGENASE;
COMPND   3 CHAIN: A;
COMPND   4 SYNONYM: 1,3,4,6-TETRACHLORO-1,4-CYCLOHEXADIENE HALIDOHYDROLASE,4-
COMPND   5 TCDN HALIDOHYDROLASE;
COMPND   6 EC: 3.8.1.5;
COMPND   7 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: SPHINGOBIUM JAPONICUM (STRAIN DSM 16413 / CCM
SOURCE   3 7287 / MTCC 6362 / UT26 / NBRC 101211 / UT26S);
SOURCE   4 ORGANISM_TAXID: 452662;
SOURCE   5 STRAIN: DSM 16413 / CCM 7287 / MTCC 6362 / UT26 / NBRC 101211 /
SOURCE   6 UT26S;
SOURCE   7 GENE: LINB, SJA_C1-19590;
SOURCE   8 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   9 EXPRESSION_SYSTEM_TAXID: 562
KEYWDS    HALOALKANE DEHALOGENASE, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    M.MAREK
REVDAT   1   02-MAR-22 7NFZ    0
JRNL        AUTH   M.MAREK,J.DAMBORSKY
JRNL        TITL   CRYSTAL STRUCTURE OF HALOALKANE DEHALOGENASE LINB57 MUTANT
JRNL        TITL 2 (H272F) FROM SPHINGOBIUM JAPONICUM UT26
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   2
REMARK   2 RESOLUTION.    1.55 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX 1.19.1-4122
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : ML
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.55
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 44.72
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.340
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.4
REMARK   3   NUMBER OF REFLECTIONS             : 44602
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.166
REMARK   3   R VALUE            (WORKING SET) : 0.164
REMARK   3   FREE R VALUE                     : 0.190
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.860
REMARK   3   FREE R VALUE TEST SET COUNT      : 2168
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 44.7180 -  3.8245    1.00     3026   172  0.1689 0.1594
REMARK   3     2  3.8245 -  3.0359    1.00     2895   163  0.1370 0.1717
REMARK   3     3  3.0359 -  2.6522    1.00     2878   144  0.1492 0.1593
REMARK   3     4  2.6522 -  2.4097    1.00     2879   134  0.1558 0.1950
REMARK   3     5  2.4097 -  2.2370    1.00     2829   145  0.1503 0.1865
REMARK   3     6  2.2370 -  2.1051    1.00     2844   147  0.1461 0.1814
REMARK   3     7  2.1051 -  1.9997    1.00     2822   138  0.1515 0.1858
REMARK   3     8  1.9997 -  1.9126    1.00     2820   137  0.1603 0.2147
REMARK   3     9  1.9126 -  1.8390    0.99     2810   145  0.1845 0.2382
REMARK   3    10  1.8390 -  1.7755    0.99     2757   161  0.1820 0.2320
REMARK   3    11  1.7755 -  1.7200    0.99     2796   142  0.1903 0.1955
REMARK   3    12  1.7200 -  1.6708    0.99     2760   156  0.1926 0.2304
REMARK   3    13  1.6708 -  1.6269    0.99     2791   128  0.2097 0.2618
REMARK   3    14  1.6269 -  1.5872    0.98     2784   128  0.2318 0.2985
REMARK   3    15  1.5872 -  1.5511    0.98     2743   128  0.2588 0.2655
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL
REMARK   3   SOLVENT RADIUS     : 1.11
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.150
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 18.880
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 16.80
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :   NULL           NULL
REMARK   3   ANGLE     :   NULL           NULL
REMARK   3   CHIRALITY :   NULL           NULL
REMARK   3   PLANARITY :   NULL           NULL
REMARK   3   DIHEDRAL  :   NULL           NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : 1
REMARK   3   TLS GROUP : 1
REMARK   3    SELECTION: ALL
REMARK   3    ORIGIN FOR THE GROUP (A): -19.0822  -0.1855   4.1442
REMARK   3    T TENSOR
REMARK   3      T11:   0.0801 T22:   0.0671
REMARK   3      T33:   0.0801 T12:   0.0039
REMARK   3      T13:   0.0004 T23:  -0.0032
REMARK   3    L TENSOR
REMARK   3      L11:   0.3358 L22:   0.3794
REMARK   3      L33:   1.0134 L12:  -0.0547
REMARK   3      L13:  -0.1567 L23:   0.0878
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0232 S12:   0.0004 S13:  -0.0253
REMARK   3      S21:   0.0252 S22:  -0.0037 S23:   0.0132
REMARK   3      S31:   0.2144 S32:  -0.0071 S33:  -0.0235
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 7NFZ COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 08-FEB-21.
REMARK 100 THE DEPOSITION ID IS D_1292113883.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 12-MAY-19
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 10.5
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : SLS
REMARK 200  BEAMLINE                       : X06DA
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.0
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : PIXEL
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS PILATUS 2M-F
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200  DATA SCALING SOFTWARE          : AIMLESS
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 44672
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.550
REMARK 200  RESOLUTION RANGE LOW       (A) : 45.090
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.5
REMARK 200  DATA REDUNDANCY                : 13.50
REMARK 200  R MERGE                    (I) : 0.19300
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 11.1000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.55
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.58
REMARK 200  COMPLETENESS FOR SHELL     (%) : 97.2
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL
REMARK 200  R MERGE FOR SHELL          (I) : 1.90700
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 1.400
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: 1MJ5
REMARK 200
REMARK 200 REMARK: PLATE-LIKE SHAPE
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 44.98
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.24
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: SODIUM DI-HYDROGEN PHOSPHATE, DI
REMARK 280  -POTASSIUM HYDROGEN PHOSPHATE, LITHIUM SULPHATE, CAPS, PH 10.5,
REMARK 280  VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 293.15K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X+1/2,-Y,Z+1/2
REMARK 290       3555   -X,Y+1/2,-Z+1/2
REMARK 290       4555   X+1/2,-Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       25.74800
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       45.08550
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       32.72400
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       45.08550
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       25.74800
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       32.72400
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 3090 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 11260 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: 20.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A     1
REMARK 465     ALA A   296
REMARK 465     HIS A   297
REMARK 465     HIS A   298
REMARK 465     HIS A   299
REMARK 465     HIS A   300
REMARK 465     HIS A   301
REMARK 465     HIS A   302
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     GLU A  10    CB   CG   CD   OE1  OE2
REMARK 470     ASP A  73    CG   OD1  OD2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    LEU A   3     -169.53    -76.59
REMARK 500    PRO A  39       45.16   -103.18
REMARK 500    THR A  40     -160.21   -102.25
REMARK 500    TYR A  80       33.49     74.00
REMARK 500    ASP A  97       62.45     60.49
REMARK 500    ASP A 108     -132.53     60.25
REMARK 500    GLN A 172      -50.13   -125.04
REMARK 500    ALA A 271      -95.57   -104.33
REMARK 500
REMARK 500 REMARK: NULL
REMARK 525
REMARK 525 SOLVENT
REMARK 525
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 525 NUMBER; I=INSERTION CODE):
REMARK 525
REMARK 525  M RES CSSEQI
REMARK 525    HOH A 745        DISTANCE =  5.90 ANGSTROMS
REMARK 525    HOH A 746        DISTANCE =  8.72 ANGSTROMS
REMARK 620
REMARK 620 METAL COORDINATION
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                               K A 410   K
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 SER A   2   O
REMARK 620 2 SER A   2   OG   70.5
REMARK 620 3 LEU A   3   O    65.7  70.3
REMARK 620 4 ASN A  47   OD1  74.3 140.4  79.1
REMARK 620 5 HOH A 619   O   130.6 149.9 134.4  69.3
REMARK 620 6 HOH A 652   O    66.7  84.4 131.2  98.1  86.3
REMARK 620 7 HOH A 710   O   141.0 104.8  76.2  91.2  72.6 152.3
REMARK 620 N                    1     2     3     4     5     6
DBREF  7NFZ A    1   296  UNP    D4Z2G1   LINB_SPHJU       1    296
SEQADV 7NFZ PHE A  272  UNP  D4Z2G1    HIS   272 ENGINEERED MUTATION
SEQADV 7NFZ HIS A  297  UNP  D4Z2G1              EXPRESSION TAG
SEQADV 7NFZ HIS A  298  UNP  D4Z2G1              EXPRESSION TAG
SEQADV 7NFZ HIS A  299  UNP  D4Z2G1              EXPRESSION TAG
SEQADV 7NFZ HIS A  300  UNP  D4Z2G1              EXPRESSION TAG
SEQADV 7NFZ HIS A  301  UNP  D4Z2G1              EXPRESSION TAG
SEQADV 7NFZ HIS A  302  UNP  D4Z2G1              EXPRESSION TAG
SEQRES   1 A  302  MET SER LEU GLY ALA LYS PRO PHE GLY GLU LYS LYS PHE
SEQRES   2 A  302  ILE GLU ILE LYS GLY ARG ARG MET ALA TYR ILE ASP GLU
SEQRES   3 A  302  GLY THR GLY ASP PRO ILE LEU PHE GLN HIS GLY ASN PRO
SEQRES   4 A  302  THR SER SER TYR LEU TRP ARG ASN ILE MET PRO HIS CYS
SEQRES   5 A  302  ALA GLY LEU GLY ARG LEU ILE ALA CYS ASP LEU ILE GLY
SEQRES   6 A  302  MET GLY ASP SER ASP LYS LEU ASP PRO SER GLY PRO GLU
SEQRES   7 A  302  ARG TYR ALA TYR ALA GLU HIS ARG ASP TYR LEU ASP ALA
SEQRES   8 A  302  LEU TRP GLU ALA LEU ASP LEU GLY ASP ARG VAL VAL LEU
SEQRES   9 A  302  VAL VAL HIS ASP TRP GLY SER ALA LEU GLY PHE ASP TRP
SEQRES  10 A  302  ALA ARG ARG HIS ARG GLU ARG VAL GLN GLY ILE ALA TYR
SEQRES  11 A  302  MET GLU ALA ILE ALA MET PRO ILE GLU TRP ALA ASP PHE
SEQRES  12 A  302  PRO GLU GLN ASP ARG ASP LEU PHE GLN ALA PHE ARG SER
SEQRES  13 A  302  GLN ALA GLY GLU GLU LEU VAL LEU GLN ASP ASN VAL PHE
SEQRES  14 A  302  VAL GLU GLN VAL LEU PRO GLY LEU ILE LEU ARG PRO LEU
SEQRES  15 A  302  SER GLU ALA GLU MET ALA ALA TYR ARG GLU PRO PHE LEU
SEQRES  16 A  302  ALA ALA GLY GLU ALA ARG ARG PRO THR LEU SER TRP PRO
SEQRES  17 A  302  ARG GLN ILE PRO ILE ALA GLY THR PRO ALA ASP VAL VAL
SEQRES  18 A  302  ALA ILE ALA ARG ASP TYR ALA GLY TRP LEU SER GLU SER
SEQRES  19 A  302  PRO ILE PRO LYS LEU PHE ILE ASN ALA GLU PRO GLY ALA
SEQRES  20 A  302  LEU THR THR GLY ARG MET ARG ASP PHE CYS ARG THR TRP
SEQRES  21 A  302  PRO ASN GLN THR GLU ILE THR VAL ALA GLY ALA PHE PHE
SEQRES  22 A  302  ILE GLN GLU ASP SER PRO ASP GLU ILE GLY ALA ALA ILE
SEQRES  23 A  302  ALA ALA PHE VAL ARG ARG LEU ARG PRO ALA HIS HIS HIS
SEQRES  24 A  302  HIS HIS HIS
HET    CXS  A 401      14
HET    CXS  A 402      28
HET    CXS  A 403      14
HET    CXS  A 404      14
HET    GOL  A 405       6
HET    GOL  A 406       6
HET    GOL  A 407       6
HET    TRS  A 408       8
HET    PO4  A 409       5
HET      K  A 410       1
HETNAM     CXS 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID
HETNAM     GOL GLYCEROL
HETNAM     TRS 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
HETNAM     PO4 PHOSPHATE ION
HETNAM       K POTASSIUM ION
HETSYN     GOL GLYCERIN; PROPANE-1,2,3-TRIOL
HETSYN     TRS TRIS BUFFER
FORMUL   2  CXS    4(C9 H19 N O3 S)
FORMUL   6  GOL    3(C3 H8 O3)
FORMUL   9  TRS    C4 H12 N O3 1+
FORMUL  10  PO4    O4 P 3-
FORMUL  11    K    K 1+
FORMUL  12  HOH   *246(H2 O)
HELIX    1 AA1 SER A   41  ARG A   46  5                                   6
HELIX    2 AA2 ILE A   48  ALA A   53  5                                   6
HELIX    3 AA3 ALA A   81  LEU A   96  1                                  16
HELIX    4 AA4 ASP A  108  HIS A  121  1                                  14
HELIX    5 AA5 GLU A  139  PHE A  143  5                                   5
HELIX    6 AA6 PRO A  144  ARG A  155  1                                  12
HELIX    7 AA7 ALA A  158  GLN A  165  1                                   8
HELIX    8 AA8 ASN A  167  GLN A  172  1                                   6
HELIX    9 AA9 GLN A  172  LEU A  177  1                                   6
HELIX   10 AB1 SER A  183  GLU A  192  1                                  10
HELIX   11 AB2 PRO A  193  LEU A  195  5                                   3
HELIX   12 AB3 GLY A  198  ALA A  200  5                                   3
HELIX   13 AB4 ARG A  201  TRP A  207  1                                   7
HELIX   14 AB5 PRO A  208  ILE A  211  5                                   4
HELIX   15 AB6 PRO A  217  SER A  234  1                                  18
HELIX   16 AB7 GLY A  251  ARG A  258  1                                   8
HELIX   17 AB8 PHE A  273  ASP A  277  5                                   5
HELIX   18 AB9 SER A  278  ARG A  294  1                                  17
SHEET    1 AA1 8 LYS A  12  ILE A  16  0
SHEET    2 AA1 8 ARG A  19  GLU A  26 -1  O  ARG A  19   N  ILE A  16
SHEET    3 AA1 8 ARG A  57  CYS A  61 -1  O  LEU A  58   N  GLU A  26
SHEET    4 AA1 8 PRO A  31  GLN A  35  1  N  PHE A  34   O  ILE A  59
SHEET    5 AA1 8 VAL A 102  HIS A 107  1  O  VAL A 105   N  LEU A  33
SHEET    6 AA1 8 VAL A 125  MET A 131  1  O  ALA A 129   N  LEU A 104
SHEET    7 AA1 8 LYS A 238  PRO A 245  1  O  LEU A 239   N  TYR A 130
SHEET    8 AA1 8 GLN A 263  GLY A 270  1  O  THR A 264   N  PHE A 240
LINK         O   SER A   2                 K     K A 410     1555   1555  2.87
LINK         OG  SER A   2                 K     K A 410     1555   1555  2.84
LINK         O   LEU A   3                 K     K A 410     1555   1555  2.94
LINK         OD1 ASN A  47                 K     K A 410     1555   1555  2.69
LINK         K     K A 410                 O   HOH A 619     1555   1555  3.27
LINK         K     K A 410                 O   HOH A 652     1555   1555  2.96
LINK         K     K A 410                 O   HOH A 710     1555   1555  2.95
CISPEP   1 ASN A   38    PRO A   39          0        -6.88
CISPEP   2 ASP A   73    PRO A   74          0        -1.69
CISPEP   3 THR A  216    PRO A  217          0        -7.08
CISPEP   4 GLU A  244    PRO A  245          0         4.38
CRYST1   51.496   65.448   90.171  90.00  90.00  90.00 P 21 21 21    4
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.019419  0.000000  0.000000        0.00000
SCALE2      0.000000  0.015279  0.000000        0.00000
SCALE3      0.000000  0.000000  0.011090        0.00000
TER    2400      PRO A 295
MASTER      300    0   10   18    8    0    0    6 2649    1  110   24
END