longtext: 7o8b-pdb

content
HEADER    HYDROLASE                               15-APR-21   7O8B
TITLE     STRUCTURE OF HALOALKANE DEHALOGENASE VARIANT DHAA80 FROM RHODOCOCCUS
TITLE    2 RHODOCHROUS
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: HALOALKANE DEHALOGENASE;
COMPND   3 CHAIN: A;
COMPND   4 EC: 3.8.1.5;
COMPND   5 ENGINEERED: YES;
COMPND   6 MUTATION: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: RHODOCOCCUS RHODOCHROUS;
SOURCE   3 ORGANISM_TAXID: 1829;
SOURCE   4 GENE: DHAA;
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3);
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 469008
KEYWDS    ALPHA/BETA HYDROLASE FOLD, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    A.SHAPOSHNIKOVA,T.PRUDNIKOVA,I.KUTA SMATANOVA
REVDAT   1   08-SEP-21 7O8B    0
JRNL        AUTH   A.SHAPOSHNIKOVA,M.KUTY,R.CHALOUPKOVA,J.DAMBORSKY,B.MINOFAR,
JRNL        AUTH 2 T.PRUDNIKOVA
JRNL        TITL   STABILIZATION OF HALOALKANE DEHALOGENASE STRUCTURE BY
JRNL        TITL 2 INTERFACIAL INTERACTION WITH IONIC LIQUIDS
JRNL        REF    CRYSTALS                      V.  11       2021
JRNL        REFN                   ESSN 2073-4352
JRNL        DOI    10.3390/CRYST11091052
REMARK   2
REMARK   2 RESOLUTION.    1.75 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.8.0267
REMARK   3   AUTHORS     : MURSHUDOV,SKUBAK,LEBEDEV,PANNU,STEINER,
REMARK   3               : NICHOLLS,WINN,LONG,VAGIN
REMARK   3
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.75
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 32.15
REMARK   3   DATA CUTOFF            (SIGMA(F)) : NULL
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.2
REMARK   3   NUMBER OF REFLECTIONS             : 29090
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.209
REMARK   3   R VALUE            (WORKING SET) : 0.208
REMARK   3   FREE R VALUE                     : 0.224
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.000
REMARK   3   FREE R VALUE TEST SET COUNT      : 1532
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : NULL
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 1.75
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 1.79
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 2013
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 94.64
REMARK   3   BIN R VALUE           (WORKING SET) : 0.3690
REMARK   3   BIN FREE R VALUE SET COUNT          : 106
REMARK   3   BIN FREE R VALUE                    : 0.3760
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 2343
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 6
REMARK   3   SOLVENT ATOMS            : 133
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 29.62
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : -3.37000
REMARK   3    B22 (A**2) : 2.36000
REMARK   3    B33 (A**2) : 1.01000
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : 0.00000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): 0.134
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.117
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.107
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 7.281
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.955
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.953
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A):  2450 ; 0.004 ; 0.017
REMARK   3   BOND LENGTHS OTHERS               (A):  2264 ; 0.001 ; 0.019
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES):  3356 ; 1.071 ; 1.852
REMARK   3   BOND ANGLES OTHERS          (DEGREES):  5230 ; 0.974 ; 2.628
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):   293 ; 5.087 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   135 ;30.294 ;21.704
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):   371 ;11.940 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):    17 ;17.305 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):   352 ; 0.067 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A):  2758 ; 0.003 ; 0.020
REMARK   3   GENERAL PLANES OTHERS             (A):   564 ; 0.001 ; 0.020
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  1169 ; 0.698 ; 0.944
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  1168 ; 0.693 ; 0.942
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  1463 ; 1.168 ; 1.412
REMARK   3   MAIN-CHAIN ANGLE OTHER ATOMS   (A**2):  1464 ; 1.168 ; 1.414
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  1281 ; 0.937 ; 1.026
REMARK   3   SIDE-CHAIN BOND OTHER ATOMS    (A**2):  1276 ; 0.813 ; 1.017
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN ANGLE OTHER ATOMS   (A**2):  1886 ; 1.303 ; 1.495
REMARK   3   LONG RANGE B REFINED ATOMS     (A**2):  2766 ; 4.977 ;11.718
REMARK   3   LONG RANGE B OTHER ATOMS       (A**2):  2755 ; 4.945 ;11.531
REMARK   3
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : 1
REMARK   3
REMARK   3   TLS GROUP : 1
REMARK   3    NUMBER OF COMPONENTS GROUP : 1
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI
REMARK   3    RESIDUE RANGE :   A     4        A   293
REMARK   3    ORIGIN FOR THE GROUP (A): -10.1560  13.0570 -17.4730
REMARK   3    T TENSOR
REMARK   3      T11:   0.3106 T22:   0.0115
REMARK   3      T33:   0.0635 T12:   0.0066
REMARK   3      T13:  -0.0374 T23:  -0.0088
REMARK   3    L TENSOR
REMARK   3      L11:   1.8292 L22:   2.3554
REMARK   3      L33:   1.3163 L12:   0.2824
REMARK   3      L13:  -0.0915 L23:   0.1094
REMARK   3    S TENSOR
REMARK   3      S11:   0.0154 S12:   0.0993 S13:  -0.0288
REMARK   3      S21:  -0.1625 S22:  -0.0282 S23:   0.1799
REMARK   3      S31:   0.0014 S32:  -0.0882 S33:   0.0129
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : MASK
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.20
REMARK   3   ION PROBE RADIUS   : 0.70
REMARK   3   SHRINKAGE RADIUS   : 0.70
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: U VALUES : WITH TLS ADDED
REMARK   3  HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
REMARK   3  U VALUES : RESIDUAL ONLY
REMARK   4
REMARK   4 7O8B COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 15-APR-21.
REMARK 100 THE DEPOSITION ID IS D_1292115283.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 29-JAN-15
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 6.5
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : BESSY
REMARK 200  BEAMLINE                       : 14.2
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9184
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : MARMOSAIC 225 MM CCD
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200  DATA SCALING SOFTWARE          : XDS
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 29090
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.750
REMARK 200  RESOLUTION RANGE LOW       (A) : 32.150
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.2
REMARK 200  DATA REDUNDANCY                : 2.000
REMARK 200  R MERGE                    (I) : NULL
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 1.8600
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.75
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.79
REMARK 200  COMPLETENESS FOR SHELL     (%) : NULL
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL
REMARK 200  R MERGE FOR SHELL          (I) : NULL
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: MOLREP
REMARK 200 STARTING MODEL: 4F60
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 43.66
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.18
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.1M BISTRIS PROPANE, 0.2M SODIUM
REMARK 280  FLUORIDE,20% PEG3350, 50% W/V 1-BUTYL-3-METHYLIMIDAZOLIUM METHYL
REMARK 280  SULFATE, PH 6.5, VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 277K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X+1/2,-Y,Z+1/2
REMARK 290       3555   -X,Y+1/2,-Z+1/2
REMARK 290       4555   X+1/2,-Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       25.44450
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       41.95800
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       34.77550
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       41.95800
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       25.44450
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       34.77550
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 0 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 11150 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: 0.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    ASP A  31      -47.25   -166.66
REMARK 500    PRO A  42       52.17   -104.05
REMARK 500    THR A  43     -161.49   -104.39
REMARK 500    GLU A  98      -85.58   -101.17
REMARK 500    ASP A 106     -123.52     54.45
REMARK 500    GLU A 130       58.56     39.08
REMARK 500    ASP A 156      -59.15     73.72
REMARK 500    VAL A 245      -72.85   -133.02
REMARK 500    LEU A 271      -98.24   -116.10
REMARK 500
REMARK 500 REMARK: NULL
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue V5B A 301
DBREF  7O8B A    4   293  UNP    P0A3G2   DHAA_RHORH       4    293
SEQADV 7O8B LEU A  148  UNP  P0A3G2    THR   148 ENGINEERED MUTATION
SEQADV 7O8B GLN A  171  UNP  P0A3G2    GLY   171 ENGINEERED MUTATION
SEQADV 7O8B VAL A  172  UNP  P0A3G2    ALA   172 ENGINEERED MUTATION
SEQADV 7O8B PHE A  176  UNP  P0A3G2    CYS   176 ENGINEERED MUTATION
SEQRES   1 A  290  ILE GLY THR GLY PHE PRO PHE ASP PRO HIS TYR VAL GLU
SEQRES   2 A  290  VAL LEU GLY GLU ARG MET HIS TYR VAL ASP VAL GLY PRO
SEQRES   3 A  290  ARG ASP GLY THR PRO VAL LEU PHE LEU HIS GLY ASN PRO
SEQRES   4 A  290  THR SER SER TYR LEU TRP ARG ASN ILE ILE PRO HIS VAL
SEQRES   5 A  290  ALA PRO SER HIS ARG CYS ILE ALA PRO ASP LEU ILE GLY
SEQRES   6 A  290  MET GLY LYS SER ASP LYS PRO ASP LEU ASP TYR PHE PHE
SEQRES   7 A  290  ASP ASP HIS VAL ARG TYR LEU ASP ALA PHE ILE GLU ALA
SEQRES   8 A  290  LEU GLY LEU GLU GLU VAL VAL LEU VAL ILE HIS ASP TRP
SEQRES   9 A  290  GLY SER ALA LEU GLY PHE HIS TRP ALA LYS ARG ASN PRO
SEQRES  10 A  290  GLU ARG VAL LYS GLY ILE ALA CYS MET GLU PHE ILE ARG
SEQRES  11 A  290  PRO ILE PRO THR TRP ASP GLU TRP PRO GLU PHE ALA ARG
SEQRES  12 A  290  GLU LEU PHE GLN ALA PHE ARG THR ALA ASP VAL GLY ARG
SEQRES  13 A  290  GLU LEU ILE ILE ASP GLN ASN ALA PHE ILE GLU GLN VAL
SEQRES  14 A  290  LEU PRO LYS PHE VAL VAL ARG PRO LEU THR GLU VAL GLU
SEQRES  15 A  290  MET ASP HIS TYR ARG GLU PRO PHE LEU LYS PRO VAL ASP
SEQRES  16 A  290  ARG GLU PRO LEU TRP ARG PHE PRO ASN GLU LEU PRO ILE
SEQRES  17 A  290  ALA GLY GLU PRO ALA ASN ILE VAL ALA LEU VAL GLU ALA
SEQRES  18 A  290  TYR MET ASN TRP LEU HIS GLN SER PRO VAL PRO LYS LEU
SEQRES  19 A  290  LEU PHE TRP GLY THR PRO GLY VAL LEU ILE PRO PRO ALA
SEQRES  20 A  290  GLU ALA ALA ARG LEU ALA GLU SER LEU PRO ASN CYS LYS
SEQRES  21 A  290  THR VAL ASP ILE GLY PRO GLY LEU HIS TYR LEU GLN GLU
SEQRES  22 A  290  ASP ASN PRO ASP LEU ILE GLY SER GLU ILE ALA ARG TRP
SEQRES  23 A  290  LEU PRO ALA LEU
HET    V5B  A 301       6
HETNAM     V5B METHYL SULFATE
FORMUL   2  V5B    C H4 O4 S
FORMUL   3  HOH   *133(H2 O)
HELIX    1 AA1 SER A   44  ARG A   49  5                                   6
HELIX    2 AA2 ILE A   51  ALA A   56  1                                   6
HELIX    3 AA3 PHE A   80  LEU A   95  1                                  16
HELIX    4 AA4 ASP A  106  ASN A  119  1                                  14
HELIX    5 AA5 THR A  137  TRP A  141  5                                   5
HELIX    6 AA6 PRO A  142  PHE A  144  5                                   3
HELIX    7 AA7 ALA A  145  ARG A  153  1                                   9
HELIX    8 AA8 ASP A  156  ILE A  163  1                                   8
HELIX    9 AA9 ASN A  166  GLN A  171  1                                   6
HELIX   10 AB1 GLN A  171  PHE A  176  1                                   6
HELIX   11 AB2 THR A  182  GLU A  191  1                                  10
HELIX   12 AB3 PRO A  192  LEU A  194  5                                   3
HELIX   13 AB4 LYS A  195  ASP A  198  5                                   4
HELIX   14 AB5 ARG A  199  PHE A  205  1                                   7
HELIX   15 AB6 PRO A  215  GLN A  231  1                                  17
HELIX   16 AB7 PRO A  248  LEU A  259  1                                  12
HELIX   17 AB8 TYR A  273  ASN A  278  1                                   6
HELIX   18 AB9 ASN A  278  LEU A  290  1                                  13
HELIX   19 AC1 PRO A  291  LEU A  293  5                                   3
SHEET    1 AA1 8 HIS A  13  VAL A  17  0
SHEET    2 AA1 8 GLU A  20  VAL A  27 -1  O  GLU A  20   N  VAL A  17
SHEET    3 AA1 8 CYS A  61  PRO A  64 -1  O  CYS A  61   N  VAL A  27
SHEET    4 AA1 8 VAL A  35  LEU A  38  1  N  PHE A  37   O  ILE A  62
SHEET    5 AA1 8 VAL A 100  HIS A 105  1  O  VAL A 101   N  LEU A  36
SHEET    6 AA1 8 VAL A 123  MET A 129  1  O  LYS A 124   N  VAL A 100
SHEET    7 AA1 8 LYS A 236  PRO A 243  1  O  LEU A 237   N  CYS A 128
SHEET    8 AA1 8 CYS A 262  GLY A 270  1  O  VAL A 265   N  LEU A 238
CISPEP   1 ASN A   41    PRO A   42          0        -7.00
CISPEP   2 GLU A  214    PRO A  215          0        -4.49
CISPEP   3 THR A  242    PRO A  243          0         3.37
SITE     1 AC1 10 ASN A  41  ASP A 106  TRP A 107  PHE A 149
SITE     2 AC1 10 PHE A 168  PHE A 205  PRO A 206  LEU A 209
SITE     3 AC1 10 HIS A 272  TYR A 273
CRYST1   50.889   69.551   83.916  90.00  90.00  90.00 P 21 21 21    4
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.019651  0.000000  0.000000        0.00000
SCALE2      0.000000  0.014378  0.000000        0.00000
SCALE3      0.000000  0.000000  0.011917        0.00000
TER    2362      LEU A 293
MASTER      290    0    1   19    8    0    3    6 2482    1    6   23
END