longtext: 7ome-pdb

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HEADER    LUMINESCENT PROTEIN                     21-MAY-21   7OME
TITLE     AZACOELENTERAZINE-BOUND RENILLA-TYPE ENGINEERED ANCESTRAL LUCIFERASE
TITLE    2 VARIANT (ANCFT7)
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: RENILLA-TYPE ENGINEERED ANCESTRAL LUCIFERASE VARIANT
COMPND   3 (ANCFT7);
COMPND   4 CHAIN: A;
COMPND   5 EC: 1.13.12.5;
COMPND   6 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT;
SOURCE   3 ORGANISM_TAXID: 32630;
SOURCE   4 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   5 EXPRESSION_SYSTEM_TAXID: 562
KEYWDS    BIOLUMINSCENCE, AZACOELENTERAZINE-BOUND ENZYME, LUMINESCENT PROTEIN
EXPDTA    X-RAY DIFFRACTION
AUTHOR    A.SCHENKMAYEROVA,Y.L.JANIN,M.MAREK
REVDAT   1   01-JUN-22 7OME    0
JRNL        AUTH   A.SCHENKMAYEROVA,Y.JANIN,J.DAMBORSKY,M.MAREK
JRNL        TITL   STRUCTURAL AND CHEMICAL BASIS OF THE RENILLA-TYPE
JRNL        TITL 2 BIOLUMINESCENCE
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   2
REMARK   2 RESOLUTION.    1.50 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX 1.14_3260
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : ML
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.50
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 39.44
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.340
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.3
REMARK   3   NUMBER OF REFLECTIONS             : 44198
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.169
REMARK   3   R VALUE            (WORKING SET) : 0.168
REMARK   3   FREE R VALUE                     : 0.190
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.820
REMARK   3   FREE R VALUE TEST SET COUNT      : 2130
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 39.4410 -  3.7008    1.00     3008   169  0.1582 0.1796
REMARK   3     2  3.7008 -  2.9378    1.00     2887   151  0.1581 0.1828
REMARK   3     3  2.9378 -  2.5665    1.00     2850   137  0.1751 0.2020
REMARK   3     4  2.5665 -  2.3319    1.00     2835   150  0.1646 0.1785
REMARK   3     5  2.3319 -  2.1647    1.00     2821   142  0.1469 0.1992
REMARK   3     6  2.1647 -  2.0371    1.00     2812   141  0.1569 0.1771
REMARK   3     7  2.0371 -  1.9351    1.00     2808   151  0.1608 0.1688
REMARK   3     8  1.9351 -  1.8509    1.00     2782   150  0.1632 0.1792
REMARK   3     9  1.8509 -  1.7796    1.00     2789   137  0.1722 0.1959
REMARK   3    10  1.7796 -  1.7182    1.00     2783   150  0.1703 0.1976
REMARK   3    11  1.7182 -  1.6645    1.00     2800   137  0.1768 0.1871
REMARK   3    12  1.6645 -  1.6169    1.00     2806   118  0.1840 0.2203
REMARK   3    13  1.6169 -  1.5743    1.00     2790   135  0.2001 0.2031
REMARK   3    14  1.5743 -  1.5359    0.98     2716   122  0.2323 0.2589
REMARK   3    15  1.5359 -  1.5010    0.92     2581   140  0.2709 0.2829
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL
REMARK   3   SOLVENT RADIUS     : 1.11
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.130
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 18.310
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 18.67
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :   NULL           NULL
REMARK   3   ANGLE     :   NULL           NULL
REMARK   3   CHIRALITY :   NULL           NULL
REMARK   3   PLANARITY :   NULL           NULL
REMARK   3   DIHEDRAL  :   NULL           NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : 1
REMARK   3   TLS GROUP : 1
REMARK   3    SELECTION: ( CHAIN A AND ( RESID 12:306 OR RESID 401:401 OR
REMARK   3               RESID 501:711 ) )
REMARK   3    ORIGIN FOR THE GROUP (A):  -10.121    1.040  -13.350
REMARK   3    T TENSOR
REMARK   3      T11:   0.0642 T22:   0.0665
REMARK   3      T33:   0.0743 T12:   0.0000
REMARK   3      T13:  -0.0004 T23:   0.0003
REMARK   3    L TENSOR
REMARK   3      L11:   0.9514 L22:   1.0875
REMARK   3      L33:   0.8281 L12:   0.1559
REMARK   3      L13:  -0.1787 L23:  -0.4426
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0051 S12:  -0.0541 S13:   0.0091
REMARK   3      S21:  -0.0408 S22:  -0.0168 S23:  -0.0111
REMARK   3      S31:   0.0647 S32:   0.0128 S33:   0.0059
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 7OME COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 22-MAY-21.
REMARK 100 THE DEPOSITION ID IS D_1292116013.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 12-JUL-20
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 9
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : SLS
REMARK 200  BEAMLINE                       : X06DA
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : PIXEL
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS PILATUS 2M-F
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200  DATA SCALING SOFTWARE          : AIMLESS 0.7.3
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 44303
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.500
REMARK 200  RESOLUTION RANGE LOW       (A) : 43.080
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.4
REMARK 200  DATA REDUNDANCY                : 11.50
REMARK 200  R MERGE                    (I) : 0.21100
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 12.7000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.50
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.53
REMARK 200  COMPLETENESS FOR SHELL     (%) : 92.1
REMARK 200  DATA REDUNDANCY IN SHELL       : 5.40
REMARK 200  R MERGE FOR SHELL          (I) : 1.49500
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: 2PSJ
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 35.05
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 1.89
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: PEG1500, SPG BUFFER, PH 9, VAPOR
REMARK 280  DIFFUSION, HANGING DROP, TEMPERATURE 293.15K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X+1/2,-Y,Z+1/2
REMARK 290       3555   -X,Y+1/2,-Z+1/2
REMARK 290       4555   X+1/2,-Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       21.53800
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       49.04800
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       32.24350
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       49.04800
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       21.53800
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       32.24350
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 0 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 11800 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: 0.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A     1
REMARK 465     VAL A     2
REMARK 465     SER A     3
REMARK 465     ALA A     4
REMARK 465     SER A     5
REMARK 465     GLN A     6
REMARK 465     ARG A     7
REMARK 465     THR A     8
REMARK 465     THR A     9
REMARK 465     SER A    10
REMARK 465     THR A    11
REMARK 465     HIS A   307
REMARK 465     HIS A   308
REMARK 465     HIS A   309
REMARK 465     HIS A   310
REMARK 465     HIS A   311
REMARK 465     HIS A   312
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    LEU A  27     -124.29     49.70
REMARK 500    SER A  29     -149.86   -142.35
REMARK 500    ASP A  37       77.65   -152.84
REMARK 500    PRO A  52       47.40   -108.35
REMARK 500    THR A  53     -159.84   -100.89
REMARK 500    ASP A 118     -135.28     52.89
REMARK 500    GLU A 142       55.99     39.95
REMARK 500    GLU A 149      -87.79    -96.40
REMARK 500    LYS A 228       63.11   -120.00
REMARK 500    PHE A 259      -68.22   -122.60
REMARK 500    LEU A 282     -137.50   -102.84
REMARK 500    PHE A 284       59.92    -92.55
REMARK 500
REMARK 500 REMARK: NULL
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue VK8 A 401
DBREF  7OME A    1   312  PDB    7OME     7OME             1    312
SEQRES   1 A  312  MET VAL SER ALA SER GLN ARG THR THR SER THR ALA THR
SEQRES   2 A  312  GLY ASP GLU TRP TRP ALA LYS CYS LYS GLN VAL ASP VAL
SEQRES   3 A  312  LEU ASP SER GLU MET SER TYR TYR ASP SER ASP PRO GLY
SEQRES   4 A  312  LYS HIS LYS ASN THR VAL ILE PHE LEU HIS GLY ASN PRO
SEQRES   5 A  312  THR SER SER TYR LEU TRP ARG ASN VAL ILE PRO HIS VAL
SEQRES   6 A  312  GLU PRO LEU ALA ARG CYS LEU ALA PRO ASP LEU ILE GLY
SEQRES   7 A  312  MET GLY LYS SER GLY LYS LEU PRO ASN HIS SER TYR ARG
SEQRES   8 A  312  PHE VAL ASP HIS TYR ARG TYR LEU SER ALA TRP PHE ASP
SEQRES   9 A  312  SER VAL ASN LEU PRO GLU LYS VAL THR ILE VAL CYS HIS
SEQRES  10 A  312  ASP TRP GLY SER GLY LEU GLY PHE HIS TRP CYS ASN GLU
SEQRES  11 A  312  HIS ARG ASP ARG VAL LYS GLY ILE VAL HIS MET GLU SER
SEQRES  12 A  312  VAL VAL ASP VAL ILE GLU SER TRP ASP GLU TRP PRO ASP
SEQRES  13 A  312  ILE GLU GLU ASP ILE ALA LEU ILE LYS SER GLU ALA GLY
SEQRES  14 A  312  GLU GLU MET VAL LEU LYS LYS ASN PHE PHE ILE GLU ARG
SEQRES  15 A  312  LEU LEU PRO SER SER ILE MET ARG LYS LEU SER GLU GLU
SEQRES  16 A  312  GLU MET ASP ALA TYR ARG GLU PRO PHE VAL GLU PRO GLY
SEQRES  17 A  312  GLU SER ARG ARG PRO THR LEU THR TRP PRO ARG GLU ILE
SEQRES  18 A  312  PRO LEU VAL LYS GLY GLY LYS PRO ASP VAL ILE GLU ILE
SEQRES  19 A  312  VAL LYS SER TYR ASN LYS TRP LEU SER THR SER LYS ASP
SEQRES  20 A  312  ILE PRO LYS LEU PHE ILE ASN ALA ASP PRO GLY PHE PHE
SEQRES  21 A  312  SER ASN ALA ILE LYS LYS VAL THR LYS ASN TRP PRO ASN
SEQRES  22 A  312  GLN LYS THR VAL THR VAL LYS GLY LEU HIS PHE LEU GLN
SEQRES  23 A  312  GLU ASP SER PRO GLU GLU ILE GLY GLU ALA ILE ALA ASP
SEQRES  24 A  312  PHE LEU ASN GLU LEU THR LYS HIS HIS HIS HIS HIS HIS
HET    VK8  A 401      32
HETNAM     VK8 6-(4-HYDROXYPHENYL)-2-[(4-HYDROXYPHENYL)METHYL]-8-
HETNAM   2 VK8  (PHENYLMETHYL)-[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-3-ONE
FORMUL   2  VK8    C25 H20 N4 O3
FORMUL   3  HOH   *211(H2 O)
HELIX    1 AA1 THR A   13  LYS A   20  1                                   8
HELIX    2 AA2 SER A   54  ARG A   59  5                                   6
HELIX    3 AA3 VAL A   61  VAL A   65  5                                   5
HELIX    4 AA4 ARG A   91  ASP A  104  1                                  14
HELIX    5 AA5 ASP A  118  HIS A  131  1                                  14
HELIX    6 AA6 ILE A  157  SER A  166  1                                  10
HELIX    7 AA7 GLU A  167  LYS A  175  1                                   9
HELIX    8 AA8 ASN A  177  ARG A  182  1                                   6
HELIX    9 AA9 ARG A  182  SER A  187  1                                   6
HELIX   10 AB1 SER A  193  GLU A  202  1                                  10
HELIX   11 AB2 PRO A  203  VAL A  205  5                                   3
HELIX   12 AB3 GLY A  208  SER A  210  5                                   3
HELIX   13 AB4 ARG A  211  GLU A  220  1                                  10
HELIX   14 AB5 LYS A  228  SER A  243  1                                  16
HELIX   15 AB6 PHE A  260  THR A  268  1                                   9
HELIX   16 AB7 PHE A  284  ASP A  288  5                                   5
HELIX   17 AB8 SER A  289  LEU A  304  1                                  16
SHEET    1 AA1 8 LYS A  22  VAL A  26  0
SHEET    2 AA1 8 SER A  29  ASP A  35 -1  O  TYR A  33   N  LYS A  22
SHEET    3 AA1 8 ARG A  70  PRO A  74 -1  O  ALA A  73   N  TYR A  34
SHEET    4 AA1 8 THR A  44  LEU A  48  1  N  VAL A  45   O  ARG A  70
SHEET    5 AA1 8 VAL A 112  HIS A 117  1  O  VAL A 115   N  ILE A  46
SHEET    6 AA1 8 VAL A 135  MET A 141  1  O  VAL A 139   N  ILE A 114
SHEET    7 AA1 8 LYS A 250  PRO A 257  1  O  ILE A 253   N  HIS A 140
SHEET    8 AA1 8 GLN A 274  GLY A 281  1  O  LYS A 275   N  PHE A 252
CISPEP   1 ASN A   51    PRO A   52          0         2.61
CISPEP   2 ASP A  256    PRO A  257          0         5.31
SITE     1 AC1 16 ASP A 118  TRP A 119  GLU A 142  SER A 143
SITE     2 AC1 16 VAL A 144  TRP A 154  ASP A 160  PHE A 178
SITE     3 AC1 16 LEU A 183  SER A 187  PRO A 218  PHE A 260
SITE     4 AC1 16 PHE A 284  HOH A 598  HOH A 603  HOH A 655
CRYST1   43.076   64.487   98.096  90.00  90.00  90.00 P 21 21 21    4
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.023215  0.000000  0.000000        0.00000
SCALE2      0.000000  0.015507  0.000000        0.00000
SCALE3      0.000000  0.000000  0.010194        0.00000
TER    2423      LYS A 306
MASTER      280    0    1   17    8    0    4    6 2639    1   32   24
END