longtext: 7px8-pdb

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HEADER    HYDROLASE                               08-OCT-21   7PX8
TITLE     CRYOEM STRUCTURE OF MAMMALIAN ACYLAMINOACYL-PEPTIDASE
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: ACYLAMINO-ACID-RELEASING ENZYME;
COMPND   3 CHAIN: A, B, C, D
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: SUS SCROFA DOMESTICUS;
SOURCE   3 ORGANISM_COMMON: DOMESTIC PIG;
SOURCE   4 ORGANISM_TAXID: 9825
KEYWDS    ACYLAMINOACYL-PEPTIDASE, TETRAMER, ACLYPEPTIDE-HYDROLASE, OXIDIZED
KEYWDS   2 PROTEIN HYDROLASE, SERINE-PROTEASE, HYDROLASE
EXPDTA    ELECTRON MICROSCOPY
AUTHOR    A.J.KISS-SZEMAN,V.HARMAT,D.K.MENYHARD,P.STRANER,I.JAKLI,N.HOSOGI,
AUTHOR   2 A.PERCZEL
REVDAT   1   25-MAY-22 7PX8    0
JRNL        AUTH   A.J.KISS-SZEMAN,P.STRANER,I.JAKLI,N.HOSOGI,V.HARMAT,
JRNL        AUTH 2 D.K.MENYHARD,A.PERCZEL
JRNL        TITL   CRYO-EM STRUCTURE OF ACYLPEPTIDE HYDROLASE REVEALS SUBSTRATE
JRNL        TITL 2 SELECTION BY MULTIMERIZATION AND A MULTI-STATE
JRNL        TITL 3 SERINE-PROTEASE TRIAD
JRNL        REF    CHEM SCI                                   2022
JRNL        REFN                   ESSN 2041-6539
JRNL        DOI    10.1039/D2SC02276A
REMARK   2
REMARK   2 RESOLUTION.    3.27 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   SOFTWARE PACKAGES      : JADAS, CTFFIND
REMARK   3   RECONSTRUCTION SCHEMA  : NULL
REMARK   3
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT
REMARK   3   PDB ENTRY                    : NULL
REMARK   3   REFINEMENT SPACE             : NULL
REMARK   3   REFINEMENT PROTOCOL          : NULL
REMARK   3   REFINEMENT TARGET            : NULL
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL
REMARK   3
REMARK   3 FITTING PROCEDURE : NULL
REMARK   3
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 3.270
REMARK   3   NUMBER OF PARTICLES               : 50604
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING ONLY
REMARK   3
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL
REMARK   3
REMARK   3 OTHER DETAILS: NULL
REMARK   4
REMARK   4 7PX8 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 08-OCT-21.
REMARK 100 THE DEPOSITION ID IS D_1292118571.
REMARK 245
REMARK 245 EXPERIMENTAL DETAILS
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE
REMARK 245   SPECIMEN TYPE                  : NULL
REMARK 245
REMARK 245 ELECTRON MICROSCOPE SAMPLE
REMARK 245   SAMPLE TYPE                    : PARTICLE
REMARK 245   PARTICLE TYPE                  : POINT
REMARK 245   NAME OF SAMPLE                 : HOMOTETRAMER OF ACYLAMINOACYL
REMARK 245                                    -PEPTIDASE
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : 6.00
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL
REMARK 245   SAMPLE BUFFER                  : NULL
REMARK 245   PH                             : 7.50
REMARK 245   SAMPLE DETAILS                 : NULL
REMARK 245
REMARK 245 DATA ACQUISITION
REMARK 245   DATE OF EXPERIMENT                : NULL
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : 1157
REMARK 245   TEMPERATURE (KELVIN)              : NULL
REMARK 245   MICROSCOPE MODEL                  : JEOL CRYO ARM 300
REMARK 245   DETECTOR TYPE                     : GATAN K3 (6K X 4K)
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL
REMARK 245   NOMINAL CS                        : 2.70
REMARK 245   IMAGING MODE                      : BRIGHT FIELD
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 4000.00
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM
REMARK 245   NOMINAL MAGNIFICATION             : NULL
REMARK 245   CALIBRATED MAGNIFICATION          : NULL
REMARK 245   SOURCE                            : FIELD EMISSION GUN
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300
REMARK 245   IMAGING DETAILS                   : NULL
REMARK 247
REMARK 247 ELECTRON MICROSCOPY
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION
REMARK 247  OF THE STRUCTURE FACTORS.
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A     1
REMARK 465     GLU A     2
REMARK 465     ARG A     3
REMARK 465     GLN A     4
REMARK 465     VAL A     5
REMARK 465     LEU A     6
REMARK 465     LEU A     7
REMARK 465     SER A     8
REMARK 465     GLY A   110
REMARK 465     GLY A   111
REMARK 465     THR A   112
REMARK 465     GLY A   113
REMARK 465     THR A   114
REMARK 465     ALA A   115
REMARK 465     ASP A   183
REMARK 465     VAL A   184
REMARK 465     THR A   185
REMARK 465     GLY A   186
REMARK 465     SER A   187
REMARK 465     ASP A   188
REMARK 465     ASP A   189
REMARK 465     GLU A   190
REMARK 465     MET A   191
REMARK 465     ALA A   192
REMARK 465     ARG A   193
REMARK 465     THR A   194
REMARK 465     LYS A   195
REMARK 465     LYS A   196
REMARK 465     PRO A   197
REMARK 465     ASP A   198
REMARK 465     GLU A   496
REMARK 465     LYS A   497
REMARK 465     MET B     1
REMARK 465     GLU B     2
REMARK 465     ARG B     3
REMARK 465     GLN B     4
REMARK 465     VAL B     5
REMARK 465     LEU B     6
REMARK 465     LEU B     7
REMARK 465     SER B     8
REMARK 465     GLY B   110
REMARK 465     GLY B   111
REMARK 465     THR B   112
REMARK 465     GLY B   113
REMARK 465     THR B   114
REMARK 465     ALA B   115
REMARK 465     ASP B   183
REMARK 465     VAL B   184
REMARK 465     THR B   185
REMARK 465     GLY B   186
REMARK 465     SER B   187
REMARK 465     ASP B   188
REMARK 465     ASP B   189
REMARK 465     GLU B   190
REMARK 465     MET B   191
REMARK 465     ALA B   192
REMARK 465     ARG B   193
REMARK 465     THR B   194
REMARK 465     LYS B   195
REMARK 465     LYS B   196
REMARK 465     PRO B   197
REMARK 465     ASP B   198
REMARK 465     GLU B   496
REMARK 465     LYS B   497
REMARK 465     MET C     1
REMARK 465     GLU C     2
REMARK 465     ARG C     3
REMARK 465     GLN C     4
REMARK 465     VAL C     5
REMARK 465     LEU C     6
REMARK 465     LEU C     7
REMARK 465     SER C     8
REMARK 465     TYR C    39
REMARK 465     GLY C   110
REMARK 465     GLY C   111
REMARK 465     THR C   112
REMARK 465     GLY C   113
REMARK 465     THR C   114
REMARK 465     ALA C   115
REMARK 465     ASP C   183
REMARK 465     VAL C   184
REMARK 465     THR C   185
REMARK 465     GLY C   186
REMARK 465     SER C   187
REMARK 465     ASP C   188
REMARK 465     ASP C   189
REMARK 465     GLU C   190
REMARK 465     MET C   191
REMARK 465     ALA C   192
REMARK 465     ARG C   193
REMARK 465     THR C   194
REMARK 465     LYS C   195
REMARK 465     LYS C   196
REMARK 465     PRO C   197
REMARK 465     ASP C   198
REMARK 465     GLU C   496
REMARK 465     LYS C   497
REMARK 465     MET D     1
REMARK 465     GLU D     2
REMARK 465     ARG D     3
REMARK 465     GLN D     4
REMARK 465     VAL D     5
REMARK 465     LEU D     6
REMARK 465     LEU D     7
REMARK 465     SER D     8
REMARK 465     TYR D    39
REMARK 465     GLY D   110
REMARK 465     GLY D   111
REMARK 465     THR D   112
REMARK 465     GLY D   113
REMARK 465     THR D   114
REMARK 465     ALA D   115
REMARK 465     ASP D   183
REMARK 465     VAL D   184
REMARK 465     THR D   185
REMARK 465     GLY D   186
REMARK 465     SER D   187
REMARK 465     ASP D   188
REMARK 465     ASP D   189
REMARK 465     GLU D   190
REMARK 465     MET D   191
REMARK 465     ALA D   192
REMARK 465     ARG D   193
REMARK 465     THR D   194
REMARK 465     LYS D   195
REMARK 465     LYS D   196
REMARK 465     PRO D   197
REMARK 465     ASP D   198
REMARK 465     GLU D   496
REMARK 465     LYS D   497
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     GLU A   9    CG   CD   OE1  OE2
REMARK 470     GLU A  11    CG   CD   OE1  OE2
REMARK 470     GLU A  12    CG   CD   OE1  OE2
REMARK 470     GLN A  38    CG   CD   OE1  NE2
REMARK 470     TYR A  39    CG   CD1  CD2  CE1  CE2  CZ   OH
REMARK 470     GLU A  49    CG   CD   OE1  OE2
REMARK 470     GLU A  59    CG   CD   OE1  OE2
REMARK 470     ASP A  72    CG   OD1  OD2
REMARK 470     ASP A  74    CG   OD1  OD2
REMARK 470     ARG A  89    CG   CD   NE   CZ   NH1  NH2
REMARK 470     GLU A 116    CG   CD   OE1  OE2
REMARK 470     GLU A 117    CG   CD   OE1  OE2
REMARK 470     LYS A 131    NZ
REMARK 470     GLU A 139    CG   CD   OE1  OE2
REMARK 470     ASP A 148    CG   OD1  OD2
REMARK 470     SER A 158    OG
REMARK 470     THR A 160    OG1  CG2
REMARK 470     LYS A 172    CG   CD   CE   NZ
REMARK 470     GLU A 174    CG   CD   OE1  OE2
REMARK 470     GLN A 178    CD   OE1  NE2
REMARK 470     LYS A 180    NZ
REMARK 470     LEU A 182    CG   CD1  CD2
REMARK 470     GLN A 199    CG   CD   OE1  NE2
REMARK 470     ASN A 215    CG   OD1  ND2
REMARK 470     GLU A 230    CG   CD   OE1  OE2
REMARK 470     GLU A 238    CG   CD   OE1  OE2
REMARK 470     GLU A 242    CG   CD   OE1  OE2
REMARK 470     LYS A 291    CD   CE   NZ
REMARK 470     ASP A 297    CG   OD1  OD2
REMARK 470     GLU A 298    CG   CD   OE1  OE2
REMARK 470     SER A 299    OG
REMARK 470     GLN A 351    CD   OE1  NE2
REMARK 470     GLU A 354    CG   CD   OE1  OE2
REMARK 470     ASP A 372    CG   OD1  OD2
REMARK 470     GLN A 394    CG   CD   OE1  NE2
REMARK 470     MET A 395    CG   SD   CE
REMARK 470     LYS A 411    NZ
REMARK 470     ASP A 416    CG   OD1  OD2
REMARK 470     LYS A 443    CG   CD   CE   NZ
REMARK 470     GLU A 456    CG   CD   OE1  OE2
REMARK 470     GLN A 473    CG   CD   OE1  NE2
REMARK 470     VAL A 477    CG1  CG2
REMARK 470     THR A 498    OG1  CG2
REMARK 470     GLN A 499    CG   CD   OE1  NE2
REMARK 470     GLU A 573    CG   CD   OE1  OE2
REMARK 470     GLU A 574    CG   CD   OE1  OE2
REMARK 470     HIS A 575    CG   ND1  CD2  CE1  NE2
REMARK 470     ASP A 577    CG   OD1  OD2
REMARK 470     SER A 622    OG
REMARK 470     SER A 636    OG
REMARK 470     ASP A 640    CG   OD1  OD2
REMARK 470     LEU A 642    CG   CD1  CD2
REMARK 470     ASP A 653    CG   OD1  OD2
REMARK 470     LYS A 664    NZ
REMARK 470     GLU A 674    CG   CD   OE1  OE2
REMARK 470     GLU A 685    CG   CD   OE1  OE2
REMARK 470     ASN A 694    CG   OD1  ND2
REMARK 470     LYS A 704    CE   NZ
REMARK 470     SER A 710    OG
REMARK 470     GLU A 711    CD   OE1  OE2
REMARK 470     GLU A 713    CG   CD   OE1  OE2
REMARK 470     GLU B   9    CG   CD   OE1  OE2
REMARK 470     GLU B  11    CG   CD   OE1  OE2
REMARK 470     GLU B  12    CG   CD   OE1  OE2
REMARK 470     GLN B  38    CG   CD   OE1  NE2
REMARK 470     TYR B  39    CG   CD1  CD2  CE1  CE2  CZ   OH
REMARK 470     GLU B  59    CG   CD   OE1  OE2
REMARK 470     ASP B  72    CG   OD1  OD2
REMARK 470     ASP B  74    CG   OD1  OD2
REMARK 470     ARG B  89    CG   CD   NE   CZ   NH1  NH2
REMARK 470     GLU B 116    CG   CD   OE1  OE2
REMARK 470     LYS B 131    NZ
REMARK 470     GLU B 139    CG   CD   OE1  OE2
REMARK 470     ASP B 148    CG   OD1  OD2
REMARK 470     SER B 158    OG
REMARK 470     THR B 160    OG1  CG2
REMARK 470     LYS B 172    CG   CD   CE   NZ
REMARK 470     GLU B 174    CD   OE1  OE2
REMARK 470     GLN B 178    CD   OE1  NE2
REMARK 470     LYS B 180    CG   CD   CE   NZ
REMARK 470     LEU B 182    CG   CD1  CD2
REMARK 470     GLN B 199    CG   CD   OE1  NE2
REMARK 470     ASN B 215    CG   OD1  ND2
REMARK 470     GLU B 230    CG   CD   OE1  OE2
REMARK 470     GLU B 238    CG   CD   OE1  OE2
REMARK 470     GLU B 242    CG   CD   OE1  OE2
REMARK 470     LYS B 291    CE   NZ
REMARK 470     ASP B 297    CG   OD1  OD2
REMARK 470     GLU B 298    CG   CD   OE1  OE2
REMARK 470     SER B 299    OG
REMARK 470     GLN B 351    CG   CD   OE1  NE2
REMARK 470     GLU B 354    CG   CD   OE1  OE2
REMARK 470     ASP B 372    CG   OD1  OD2
REMARK 470     GLN B 394    CG   CD   OE1  NE2
REMARK 470     MET B 395    CG   SD   CE
REMARK 470     SER B 397    OG
REMARK 470     LYS B 411    NZ
REMARK 470     ASP B 416    CG   OD1  OD2
REMARK 470     LYS B 443    CG   CD   CE   NZ
REMARK 470     GLU B 456    CG   CD   OE1  OE2
REMARK 470     GLN B 473    CG   CD   OE1  NE2
REMARK 470     VAL B 477    CG1  CG2
REMARK 470     THR B 498    OG1  CG2
REMARK 470     GLN B 499    CG   CD   OE1  NE2
REMARK 470     GLU B 573    CG   CD   OE1  OE2
REMARK 470     GLU B 574    CG   CD   OE1  OE2
REMARK 470     ASP B 577    CG   OD1  OD2
REMARK 470     SER B 622    OG
REMARK 470     SER B 636    OG
REMARK 470     ASP B 640    CG   OD1  OD2
REMARK 470     ASP B 653    CG   OD1  OD2
REMARK 470     LYS B 664    NZ
REMARK 470     GLU B 674    CG   CD   OE1  OE2
REMARK 470     GLU B 685    CG   CD   OE1  OE2
REMARK 470     LYS B 704    CE   NZ
REMARK 470     SER B 710    OG
REMARK 470     GLU B 711    CD   OE1  OE2
REMARK 470     GLU B 713    CG   CD   OE1  OE2
REMARK 470     SER B 732    OG
REMARK 470     GLU C   9    CG   CD   OE1  OE2
REMARK 470     GLU C  11    CG   CD   OE1  OE2
REMARK 470     GLU C  12    CG   CD   OE1  OE2
REMARK 470     GLN C  38    CG   CD   OE1  NE2
REMARK 470     GLU C  59    CG   CD   OE1  OE2
REMARK 470     ASP C  72    CG   OD1  OD2
REMARK 470     ASP C  74    CG   OD1  OD2
REMARK 470     ARG C  89    CG   CD   NE   CZ   NH1  NH2
REMARK 470     GLU C 116    CG   CD   OE1  OE2
REMARK 470     LYS C 131    NZ
REMARK 470     GLU C 139    CG   CD   OE1  OE2
REMARK 470     ASP C 148    CG   OD1  OD2
REMARK 470     SER C 158    OG
REMARK 470     THR C 160    OG1  CG2
REMARK 470     LYS C 172    CG   CD   CE   NZ
REMARK 470     GLN C 178    CD   OE1  NE2
REMARK 470     LYS C 180    NZ
REMARK 470     LEU C 182    CG   CD1  CD2
REMARK 470     GLN C 199    CG   CD   OE1  NE2
REMARK 470     ASN C 215    CG   OD1  ND2
REMARK 470     SER C 218    OG
REMARK 470     GLU C 230    CG   CD   OE1  OE2
REMARK 470     GLU C 238    CG   CD   OE1  OE2
REMARK 470     GLU C 242    CG   CD   OE1  OE2
REMARK 470     THR C 288    OG1  CG2
REMARK 470     LYS C 291    CE   NZ
REMARK 470     ASP C 297    CG   OD1  OD2
REMARK 470     GLU C 298    CG   CD   OE1  OE2
REMARK 470     SER C 299    OG
REMARK 470     GLN C 351    CG   CD   OE1  NE2
REMARK 470     GLU C 354    CG   CD   OE1  OE2
REMARK 470     ASP C 372    CG   OD1  OD2
REMARK 470     GLN C 394    CG   CD   OE1  NE2
REMARK 470     MET C 395    CG   SD   CE
REMARK 470     LYS C 411    NZ
REMARK 470     ASP C 416    CG   OD1  OD2
REMARK 470     LYS C 443    CG   CD   CE   NZ
REMARK 470     GLU C 456    CG   CD   OE1  OE2
REMARK 470     GLN C 473    CG   CD   OE1  NE2
REMARK 470     VAL C 477    CG1  CG2
REMARK 470     THR C 498    OG1  CG2
REMARK 470     GLN C 499    CG   CD   OE1  NE2
REMARK 470     GLU C 573    CG   CD   OE1  OE2
REMARK 470     GLU C 574    CG   CD   OE1  OE2
REMARK 470     ASP C 577    CG   OD1  OD2
REMARK 470     SER C 622    OG
REMARK 470     SER C 636    OG
REMARK 470     ASP C 640    CG   OD1  OD2
REMARK 470     ASP C 653    CG   OD1  OD2
REMARK 470     LYS C 664    NZ
REMARK 470     GLU C 674    CG   CD   OE1  OE2
REMARK 470     GLU C 685    CG   CD   OE1  OE2
REMARK 470     LYS C 704    CE   NZ
REMARK 470     SER C 710    OG
REMARK 470     GLU C 711    CD   OE1  OE2
REMARK 470     GLU C 713    CG   CD   OE1  OE2
REMARK 470     GLU D   9    CG   CD   OE1  OE2
REMARK 470     GLU D  11    CG   CD   OE1  OE2
REMARK 470     GLU D  12    CG   CD   OE1  OE2
REMARK 470     GLN D  38    CG   CD   OE1  NE2
REMARK 470     GLU D  59    CG   CD   OE1  OE2
REMARK 470     ASP D  72    CG   OD1  OD2
REMARK 470     ASP D  74    CG   OD1  OD2
REMARK 470     ARG D  89    CG   CD   NE   CZ   NH1  NH2
REMARK 470     GLU D 116    CG   CD   OE1  OE2
REMARK 470     GLU D 117    CG   CD   OE1  OE2
REMARK 470     LYS D 131    NZ
REMARK 470     GLU D 139    CG   CD   OE1  OE2
REMARK 470     ASP D 148    CG   OD1  OD2
REMARK 470     SER D 158    OG
REMARK 470     THR D 160    OG1  CG2
REMARK 470     LYS D 172    CG   CD   CE   NZ
REMARK 470     GLN D 178    CD   OE1  NE2
REMARK 470     LYS D 180    NZ
REMARK 470     LEU D 182    CG   CD1  CD2
REMARK 470     GLN D 199    CG   CD   OE1  NE2
REMARK 470     ASN D 215    CG   OD1  ND2
REMARK 470     GLU D 230    CG   CD   OE1  OE2
REMARK 470     GLU D 238    CG   CD   OE1  OE2
REMARK 470     GLU D 242    CG   CD   OE1  OE2
REMARK 470     LYS D 291    CE   NZ
REMARK 470     ASP D 297    CG   OD1  OD2
REMARK 470     GLU D 298    CG   CD   OE1  OE2
REMARK 470     SER D 299    OG
REMARK 470     GLN D 351    CD   OE1  NE2
REMARK 470     GLU D 354    CG   CD   OE1  OE2
REMARK 470     ASP D 372    CG   OD1  OD2
REMARK 470     GLN D 394    CG   CD   OE1  NE2
REMARK 470     MET D 395    CG   SD   CE
REMARK 470     LYS D 411    NZ
REMARK 470     LYS D 443    CG   CD   CE   NZ
REMARK 470     GLU D 456    CG   CD   OE1  OE2
REMARK 470     GLN D 473    CG   CD   OE1  NE2
REMARK 470     VAL D 477    CG1  CG2
REMARK 470     ASN D 493    CG   OD1  ND2
REMARK 470     THR D 498    OG1  CG2
REMARK 470     GLN D 499    CG   CD   OE1  NE2
REMARK 470     GLU D 574    CG   CD   OE1  OE2
REMARK 470     ASP D 577    CG   OD1  OD2
REMARK 470     SER D 622    OG
REMARK 470     SER D 636    OG
REMARK 470     SER D 638    OG
REMARK 470     ASP D 640    CG   OD1  OD2
REMARK 470     ASP D 653    CG   OD1  OD2
REMARK 470     LYS D 664    NZ
REMARK 470     GLU D 674    CG   CD   OE1  OE2
REMARK 470     GLU D 685    CG   CD   OE1  OE2
REMARK 470     LYS D 704    CE   NZ
REMARK 470     SER D 710    OG
REMARK 470     GLU D 711    CD   OE1  OE2
REMARK 470     GLU D 713    CG   CD   OE1  OE2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    LYS A 126     -125.22     60.06
REMARK 500    SER A 304       70.43     52.29
REMARK 500    ARG A 383     -119.35     62.81
REMARK 500    SER A 587     -103.19     57.45
REMARK 500    LYS B 126     -125.26     60.39
REMARK 500    SER B 304       71.08     58.89
REMARK 500    VAL B 344      -60.46    -96.74
REMARK 500    GLN B 351      116.86   -161.99
REMARK 500    GLN B 474       50.49    -93.86
REMARK 500    SER B 587     -100.98     62.71
REMARK 500    SER B 622       78.93   -101.68
REMARK 500    LYS C 126     -124.76     60.16
REMARK 500    ASN C 277       57.03    -94.00
REMARK 500    SER C 304       70.86     56.15
REMARK 500    ARG C 383     -121.18     63.05
REMARK 500    ASP C 418       -1.23     70.02
REMARK 500    SER C 587      -15.76     70.78
REMARK 500    HIS C 588      -25.28   -141.56
REMARK 500    LYS D 126     -120.36     55.67
REMARK 500    ASN D 277       57.23    -94.26
REMARK 500    SER D 304       71.02     58.33
REMARK 500    VAL D 344      -60.23    -97.16
REMARK 500    ARG D 383     -119.25     63.36
REMARK 500    GLU D 574       59.48    -92.02
REMARK 500    SER D 587     -100.66     58.90
REMARK 500    SER D 587      -61.83   -103.49
REMARK 500
REMARK 500 REMARK: NULL
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: EMD-13691   RELATED DB: EMDB
REMARK 900 CRYOEM STRUCTURE OF MAMMALIAN ACYLAMINOACYL-PEPTIDASE
DBREF  7PX8 A    1   732  UNP    P19205   ACPH_PIG         1    732
DBREF  7PX8 B    1   732  UNP    P19205   ACPH_PIG         1    732
DBREF  7PX8 C    1   732  UNP    P19205   ACPH_PIG         1    732
DBREF  7PX8 D    1   732  UNP    P19205   ACPH_PIG         1    732
SEQRES   1 A  732  MET GLU ARG GLN VAL LEU LEU SER GLU PRO GLU GLU ALA
SEQRES   2 A  732  ALA ALA LEU TYR ARG GLY LEU SER ARG GLN PRO ALA LEU
SEQRES   3 A  732  SER ALA ALA CYS LEU GLY PRO GLU VAL THR THR GLN TYR
SEQRES   4 A  732  GLY GLY ARG TYR ARG THR VAL HIS THR GLU TRP THR GLN
SEQRES   5 A  732  ARG ASP LEU GLU ARG MET GLU ASN ILE ARG PHE CYS ARG
SEQRES   6 A  732  GLN TYR LEU VAL PHE HIS ASP GLY ASP SER VAL VAL PHE
SEQRES   7 A  732  ALA GLY PRO ALA GLY ASN SER VAL GLU THR ARG GLY GLU
SEQRES   8 A  732  LEU LEU SER ARG GLU SER PRO SER GLY THR MET LYS ALA
SEQRES   9 A  732  VAL LEU ARG LYS ALA GLY GLY THR GLY THR ALA GLU GLU
SEQRES  10 A  732  LYS GLN PHE LEU GLU VAL TRP GLU LYS ASN ARG LYS LEU
SEQRES  11 A  732  LYS SER PHE ASN LEU SER ALA LEU GLU LYS HIS GLY PRO
SEQRES  12 A  732  VAL TYR GLU ASP ASP CYS PHE GLY CYS LEU SER TRP SER
SEQRES  13 A  732  HIS SER GLU THR HIS LEU LEU TYR VAL ALA ASP LYS LYS
SEQRES  14 A  732  ARG PRO LYS ALA GLU SER PHE PHE GLN THR LYS ALA LEU
SEQRES  15 A  732  ASP VAL THR GLY SER ASP ASP GLU MET ALA ARG THR LYS
SEQRES  16 A  732  LYS PRO ASP GLN ALA ILE LYS GLY ASP GLN PHE LEU PHE
SEQRES  17 A  732  TYR GLU ASP TRP GLY GLU ASN MET VAL SER LYS SER THR
SEQRES  18 A  732  PRO VAL LEU CYS VAL LEU ASP ILE GLU SER GLY ASN ILE
SEQRES  19 A  732  SER VAL LEU GLU GLY VAL PRO GLU SER VAL SER PRO GLY
SEQRES  20 A  732  GLN ALA PHE TRP ALA PRO GLY ASP THR GLY VAL VAL PHE
SEQRES  21 A  732  VAL GLY TRP TRP HIS GLU PRO PHE ARG LEU GLY ILE ARG
SEQRES  22 A  732  PHE CYS THR ASN ARG ARG SER ALA LEU TYR TYR VAL ASP
SEQRES  23 A  732  LEU THR GLY GLY LYS CYS GLU LEU LEU SER ASP GLU SER
SEQRES  24 A  732  VAL ALA VAL THR SER PRO ARG LEU SER PRO ASP GLN CYS
SEQRES  25 A  732  ARG ILE VAL TYR LEU ARG PHE PRO SER LEU VAL PRO HIS
SEQRES  26 A  732  GLN GLN CYS GLY GLN LEU CYS LEU TYR ASP TRP TYR THR
SEQRES  27 A  732  ARG VAL THR SER VAL VAL VAL ASP ILE VAL PRO ARG GLN
SEQRES  28 A  732  LEU GLY GLU ASP PHE SER GLY ILE TYR CYS SER LEU LEU
SEQRES  29 A  732  PRO LEU GLY CYS TRP SER ALA ASP SER GLN ARG VAL VAL
SEQRES  30 A  732  PHE ASP SER PRO GLN ARG SER ARG GLN ASP LEU PHE ALA
SEQRES  31 A  732  VAL ASP THR GLN MET GLY SER VAL THR SER LEU THR ALA
SEQRES  32 A  732  GLY GLY SER GLY GLY SER TRP LYS LEU LEU THR ILE ASP
SEQRES  33 A  732  ARG ASP LEU MET VAL VAL GLN PHE SER THR PRO SER VAL
SEQRES  34 A  732  PRO PRO SER LEU LYS VAL GLY PHE LEU PRO PRO ALA GLY
SEQRES  35 A  732  LYS GLU GLN ALA VAL SER TRP VAL SER LEU GLU GLU ALA
SEQRES  36 A  732  GLU PRO PHE PRO ASP ILE SER TRP SER ILE ARG VAL LEU
SEQRES  37 A  732  GLN PRO PRO PRO GLN GLN GLU HIS VAL GLN TYR ALA GLY
SEQRES  38 A  732  LEU ASP PHE GLU ALA ILE LEU LEU GLN PRO SER ASN SER
SEQRES  39 A  732  PRO GLU LYS THR GLN VAL PRO MET VAL VAL MET PRO HIS
SEQRES  40 A  732  GLY GLY PRO HIS SER SER PHE VAL THR ALA TRP MET LEU
SEQRES  41 A  732  PHE PRO ALA MET LEU CYS LYS MET GLY PHE ALA VAL LEU
SEQRES  42 A  732  LEU VAL ASN TYR ARG GLY SER THR GLY PHE GLY GLN ASP
SEQRES  43 A  732  SER ILE LEU SER LEU PRO GLY ASN VAL GLY HIS GLN ASP
SEQRES  44 A  732  VAL LYS ASP VAL GLN PHE ALA VAL GLU GLN VAL LEU GLN
SEQRES  45 A  732  GLU GLU HIS PHE ASP ALA GLY ARG VAL ALA LEU MET GLY
SEQRES  46 A  732  GLY SER HIS GLY GLY PHE LEU SER CYS HIS LEU ILE GLY
SEQRES  47 A  732  GLN TYR PRO GLU THR TYR SER ALA CYS VAL VAL ARG ASN
SEQRES  48 A  732  PRO VAL ILE ASN ILE ALA SER MET MET GLY SER THR ASP
SEQRES  49 A  732  ILE PRO ASP TRP CYS MET VAL GLU ALA GLY PHE SER TYR
SEQRES  50 A  732  SER SER ASP CYS LEU PRO ASP LEU SER VAL TRP ALA ALA
SEQRES  51 A  732  MET LEU ASP LYS SER PRO ILE LYS TYR ALA PRO GLN VAL
SEQRES  52 A  732  LYS THR PRO LEU LEU LEU MET LEU GLY GLN GLU ASP ARG
SEQRES  53 A  732  ARG VAL PRO PHE LYS GLN GLY MET GLU TYR TYR ARG VAL
SEQRES  54 A  732  LEU LYS ALA ARG ASN VAL PRO VAL ARG LEU LEU LEU TYR
SEQRES  55 A  732  PRO LYS SER THR HIS ALA LEU SER GLU VAL GLU VAL GLU
SEQRES  56 A  732  SER ASP SER PHE MET ASN ALA VAL LEU TRP LEU CYS THR
SEQRES  57 A  732  HIS LEU GLY SER
SEQRES   1 B  732  MET GLU ARG GLN VAL LEU LEU SER GLU PRO GLU GLU ALA
SEQRES   2 B  732  ALA ALA LEU TYR ARG GLY LEU SER ARG GLN PRO ALA LEU
SEQRES   3 B  732  SER ALA ALA CYS LEU GLY PRO GLU VAL THR THR GLN TYR
SEQRES   4 B  732  GLY GLY ARG TYR ARG THR VAL HIS THR GLU TRP THR GLN
SEQRES   5 B  732  ARG ASP LEU GLU ARG MET GLU ASN ILE ARG PHE CYS ARG
SEQRES   6 B  732  GLN TYR LEU VAL PHE HIS ASP GLY ASP SER VAL VAL PHE
SEQRES   7 B  732  ALA GLY PRO ALA GLY ASN SER VAL GLU THR ARG GLY GLU
SEQRES   8 B  732  LEU LEU SER ARG GLU SER PRO SER GLY THR MET LYS ALA
SEQRES   9 B  732  VAL LEU ARG LYS ALA GLY GLY THR GLY THR ALA GLU GLU
SEQRES  10 B  732  LYS GLN PHE LEU GLU VAL TRP GLU LYS ASN ARG LYS LEU
SEQRES  11 B  732  LYS SER PHE ASN LEU SER ALA LEU GLU LYS HIS GLY PRO
SEQRES  12 B  732  VAL TYR GLU ASP ASP CYS PHE GLY CYS LEU SER TRP SER
SEQRES  13 B  732  HIS SER GLU THR HIS LEU LEU TYR VAL ALA ASP LYS LYS
SEQRES  14 B  732  ARG PRO LYS ALA GLU SER PHE PHE GLN THR LYS ALA LEU
SEQRES  15 B  732  ASP VAL THR GLY SER ASP ASP GLU MET ALA ARG THR LYS
SEQRES  16 B  732  LYS PRO ASP GLN ALA ILE LYS GLY ASP GLN PHE LEU PHE
SEQRES  17 B  732  TYR GLU ASP TRP GLY GLU ASN MET VAL SER LYS SER THR
SEQRES  18 B  732  PRO VAL LEU CYS VAL LEU ASP ILE GLU SER GLY ASN ILE
SEQRES  19 B  732  SER VAL LEU GLU GLY VAL PRO GLU SER VAL SER PRO GLY
SEQRES  20 B  732  GLN ALA PHE TRP ALA PRO GLY ASP THR GLY VAL VAL PHE
SEQRES  21 B  732  VAL GLY TRP TRP HIS GLU PRO PHE ARG LEU GLY ILE ARG
SEQRES  22 B  732  PHE CYS THR ASN ARG ARG SER ALA LEU TYR TYR VAL ASP
SEQRES  23 B  732  LEU THR GLY GLY LYS CYS GLU LEU LEU SER ASP GLU SER
SEQRES  24 B  732  VAL ALA VAL THR SER PRO ARG LEU SER PRO ASP GLN CYS
SEQRES  25 B  732  ARG ILE VAL TYR LEU ARG PHE PRO SER LEU VAL PRO HIS
SEQRES  26 B  732  GLN GLN CYS GLY GLN LEU CYS LEU TYR ASP TRP TYR THR
SEQRES  27 B  732  ARG VAL THR SER VAL VAL VAL ASP ILE VAL PRO ARG GLN
SEQRES  28 B  732  LEU GLY GLU ASP PHE SER GLY ILE TYR CYS SER LEU LEU
SEQRES  29 B  732  PRO LEU GLY CYS TRP SER ALA ASP SER GLN ARG VAL VAL
SEQRES  30 B  732  PHE ASP SER PRO GLN ARG SER ARG GLN ASP LEU PHE ALA
SEQRES  31 B  732  VAL ASP THR GLN MET GLY SER VAL THR SER LEU THR ALA
SEQRES  32 B  732  GLY GLY SER GLY GLY SER TRP LYS LEU LEU THR ILE ASP
SEQRES  33 B  732  ARG ASP LEU MET VAL VAL GLN PHE SER THR PRO SER VAL
SEQRES  34 B  732  PRO PRO SER LEU LYS VAL GLY PHE LEU PRO PRO ALA GLY
SEQRES  35 B  732  LYS GLU GLN ALA VAL SER TRP VAL SER LEU GLU GLU ALA
SEQRES  36 B  732  GLU PRO PHE PRO ASP ILE SER TRP SER ILE ARG VAL LEU
SEQRES  37 B  732  GLN PRO PRO PRO GLN GLN GLU HIS VAL GLN TYR ALA GLY
SEQRES  38 B  732  LEU ASP PHE GLU ALA ILE LEU LEU GLN PRO SER ASN SER
SEQRES  39 B  732  PRO GLU LYS THR GLN VAL PRO MET VAL VAL MET PRO HIS
SEQRES  40 B  732  GLY GLY PRO HIS SER SER PHE VAL THR ALA TRP MET LEU
SEQRES  41 B  732  PHE PRO ALA MET LEU CYS LYS MET GLY PHE ALA VAL LEU
SEQRES  42 B  732  LEU VAL ASN TYR ARG GLY SER THR GLY PHE GLY GLN ASP
SEQRES  43 B  732  SER ILE LEU SER LEU PRO GLY ASN VAL GLY HIS GLN ASP
SEQRES  44 B  732  VAL LYS ASP VAL GLN PHE ALA VAL GLU GLN VAL LEU GLN
SEQRES  45 B  732  GLU GLU HIS PHE ASP ALA GLY ARG VAL ALA LEU MET GLY
SEQRES  46 B  732  GLY SER HIS GLY GLY PHE LEU SER CYS HIS LEU ILE GLY
SEQRES  47 B  732  GLN TYR PRO GLU THR TYR SER ALA CYS VAL VAL ARG ASN
SEQRES  48 B  732  PRO VAL ILE ASN ILE ALA SER MET MET GLY SER THR ASP
SEQRES  49 B  732  ILE PRO ASP TRP CYS MET VAL GLU ALA GLY PHE SER TYR
SEQRES  50 B  732  SER SER ASP CYS LEU PRO ASP LEU SER VAL TRP ALA ALA
SEQRES  51 B  732  MET LEU ASP LYS SER PRO ILE LYS TYR ALA PRO GLN VAL
SEQRES  52 B  732  LYS THR PRO LEU LEU LEU MET LEU GLY GLN GLU ASP ARG
SEQRES  53 B  732  ARG VAL PRO PHE LYS GLN GLY MET GLU TYR TYR ARG VAL
SEQRES  54 B  732  LEU LYS ALA ARG ASN VAL PRO VAL ARG LEU LEU LEU TYR
SEQRES  55 B  732  PRO LYS SER THR HIS ALA LEU SER GLU VAL GLU VAL GLU
SEQRES  56 B  732  SER ASP SER PHE MET ASN ALA VAL LEU TRP LEU CYS THR
SEQRES  57 B  732  HIS LEU GLY SER
SEQRES   1 C  732  MET GLU ARG GLN VAL LEU LEU SER GLU PRO GLU GLU ALA
SEQRES   2 C  732  ALA ALA LEU TYR ARG GLY LEU SER ARG GLN PRO ALA LEU
SEQRES   3 C  732  SER ALA ALA CYS LEU GLY PRO GLU VAL THR THR GLN TYR
SEQRES   4 C  732  GLY GLY ARG TYR ARG THR VAL HIS THR GLU TRP THR GLN
SEQRES   5 C  732  ARG ASP LEU GLU ARG MET GLU ASN ILE ARG PHE CYS ARG
SEQRES   6 C  732  GLN TYR LEU VAL PHE HIS ASP GLY ASP SER VAL VAL PHE
SEQRES   7 C  732  ALA GLY PRO ALA GLY ASN SER VAL GLU THR ARG GLY GLU
SEQRES   8 C  732  LEU LEU SER ARG GLU SER PRO SER GLY THR MET LYS ALA
SEQRES   9 C  732  VAL LEU ARG LYS ALA GLY GLY THR GLY THR ALA GLU GLU
SEQRES  10 C  732  LYS GLN PHE LEU GLU VAL TRP GLU LYS ASN ARG LYS LEU
SEQRES  11 C  732  LYS SER PHE ASN LEU SER ALA LEU GLU LYS HIS GLY PRO
SEQRES  12 C  732  VAL TYR GLU ASP ASP CYS PHE GLY CYS LEU SER TRP SER
SEQRES  13 C  732  HIS SER GLU THR HIS LEU LEU TYR VAL ALA ASP LYS LYS
SEQRES  14 C  732  ARG PRO LYS ALA GLU SER PHE PHE GLN THR LYS ALA LEU
SEQRES  15 C  732  ASP VAL THR GLY SER ASP ASP GLU MET ALA ARG THR LYS
SEQRES  16 C  732  LYS PRO ASP GLN ALA ILE LYS GLY ASP GLN PHE LEU PHE
SEQRES  17 C  732  TYR GLU ASP TRP GLY GLU ASN MET VAL SER LYS SER THR
SEQRES  18 C  732  PRO VAL LEU CYS VAL LEU ASP ILE GLU SER GLY ASN ILE
SEQRES  19 C  732  SER VAL LEU GLU GLY VAL PRO GLU SER VAL SER PRO GLY
SEQRES  20 C  732  GLN ALA PHE TRP ALA PRO GLY ASP THR GLY VAL VAL PHE
SEQRES  21 C  732  VAL GLY TRP TRP HIS GLU PRO PHE ARG LEU GLY ILE ARG
SEQRES  22 C  732  PHE CYS THR ASN ARG ARG SER ALA LEU TYR TYR VAL ASP
SEQRES  23 C  732  LEU THR GLY GLY LYS CYS GLU LEU LEU SER ASP GLU SER
SEQRES  24 C  732  VAL ALA VAL THR SER PRO ARG LEU SER PRO ASP GLN CYS
SEQRES  25 C  732  ARG ILE VAL TYR LEU ARG PHE PRO SER LEU VAL PRO HIS
SEQRES  26 C  732  GLN GLN CYS GLY GLN LEU CYS LEU TYR ASP TRP TYR THR
SEQRES  27 C  732  ARG VAL THR SER VAL VAL VAL ASP ILE VAL PRO ARG GLN
SEQRES  28 C  732  LEU GLY GLU ASP PHE SER GLY ILE TYR CYS SER LEU LEU
SEQRES  29 C  732  PRO LEU GLY CYS TRP SER ALA ASP SER GLN ARG VAL VAL
SEQRES  30 C  732  PHE ASP SER PRO GLN ARG SER ARG GLN ASP LEU PHE ALA
SEQRES  31 C  732  VAL ASP THR GLN MET GLY SER VAL THR SER LEU THR ALA
SEQRES  32 C  732  GLY GLY SER GLY GLY SER TRP LYS LEU LEU THR ILE ASP
SEQRES  33 C  732  ARG ASP LEU MET VAL VAL GLN PHE SER THR PRO SER VAL
SEQRES  34 C  732  PRO PRO SER LEU LYS VAL GLY PHE LEU PRO PRO ALA GLY
SEQRES  35 C  732  LYS GLU GLN ALA VAL SER TRP VAL SER LEU GLU GLU ALA
SEQRES  36 C  732  GLU PRO PHE PRO ASP ILE SER TRP SER ILE ARG VAL LEU
SEQRES  37 C  732  GLN PRO PRO PRO GLN GLN GLU HIS VAL GLN TYR ALA GLY
SEQRES  38 C  732  LEU ASP PHE GLU ALA ILE LEU LEU GLN PRO SER ASN SER
SEQRES  39 C  732  PRO GLU LYS THR GLN VAL PRO MET VAL VAL MET PRO HIS
SEQRES  40 C  732  GLY GLY PRO HIS SER SER PHE VAL THR ALA TRP MET LEU
SEQRES  41 C  732  PHE PRO ALA MET LEU CYS LYS MET GLY PHE ALA VAL LEU
SEQRES  42 C  732  LEU VAL ASN TYR ARG GLY SER THR GLY PHE GLY GLN ASP
SEQRES  43 C  732  SER ILE LEU SER LEU PRO GLY ASN VAL GLY HIS GLN ASP
SEQRES  44 C  732  VAL LYS ASP VAL GLN PHE ALA VAL GLU GLN VAL LEU GLN
SEQRES  45 C  732  GLU GLU HIS PHE ASP ALA GLY ARG VAL ALA LEU MET GLY
SEQRES  46 C  732  GLY SER HIS GLY GLY PHE LEU SER CYS HIS LEU ILE GLY
SEQRES  47 C  732  GLN TYR PRO GLU THR TYR SER ALA CYS VAL VAL ARG ASN
SEQRES  48 C  732  PRO VAL ILE ASN ILE ALA SER MET MET GLY SER THR ASP
SEQRES  49 C  732  ILE PRO ASP TRP CYS MET VAL GLU ALA GLY PHE SER TYR
SEQRES  50 C  732  SER SER ASP CYS LEU PRO ASP LEU SER VAL TRP ALA ALA
SEQRES  51 C  732  MET LEU ASP LYS SER PRO ILE LYS TYR ALA PRO GLN VAL
SEQRES  52 C  732  LYS THR PRO LEU LEU LEU MET LEU GLY GLN GLU ASP ARG
SEQRES  53 C  732  ARG VAL PRO PHE LYS GLN GLY MET GLU TYR TYR ARG VAL
SEQRES  54 C  732  LEU LYS ALA ARG ASN VAL PRO VAL ARG LEU LEU LEU TYR
SEQRES  55 C  732  PRO LYS SER THR HIS ALA LEU SER GLU VAL GLU VAL GLU
SEQRES  56 C  732  SER ASP SER PHE MET ASN ALA VAL LEU TRP LEU CYS THR
SEQRES  57 C  732  HIS LEU GLY SER
SEQRES   1 D  732  MET GLU ARG GLN VAL LEU LEU SER GLU PRO GLU GLU ALA
SEQRES   2 D  732  ALA ALA LEU TYR ARG GLY LEU SER ARG GLN PRO ALA LEU
SEQRES   3 D  732  SER ALA ALA CYS LEU GLY PRO GLU VAL THR THR GLN TYR
SEQRES   4 D  732  GLY GLY ARG TYR ARG THR VAL HIS THR GLU TRP THR GLN
SEQRES   5 D  732  ARG ASP LEU GLU ARG MET GLU ASN ILE ARG PHE CYS ARG
SEQRES   6 D  732  GLN TYR LEU VAL PHE HIS ASP GLY ASP SER VAL VAL PHE
SEQRES   7 D  732  ALA GLY PRO ALA GLY ASN SER VAL GLU THR ARG GLY GLU
SEQRES   8 D  732  LEU LEU SER ARG GLU SER PRO SER GLY THR MET LYS ALA
SEQRES   9 D  732  VAL LEU ARG LYS ALA GLY GLY THR GLY THR ALA GLU GLU
SEQRES  10 D  732  LYS GLN PHE LEU GLU VAL TRP GLU LYS ASN ARG LYS LEU
SEQRES  11 D  732  LYS SER PHE ASN LEU SER ALA LEU GLU LYS HIS GLY PRO
SEQRES  12 D  732  VAL TYR GLU ASP ASP CYS PHE GLY CYS LEU SER TRP SER
SEQRES  13 D  732  HIS SER GLU THR HIS LEU LEU TYR VAL ALA ASP LYS LYS
SEQRES  14 D  732  ARG PRO LYS ALA GLU SER PHE PHE GLN THR LYS ALA LEU
SEQRES  15 D  732  ASP VAL THR GLY SER ASP ASP GLU MET ALA ARG THR LYS
SEQRES  16 D  732  LYS PRO ASP GLN ALA ILE LYS GLY ASP GLN PHE LEU PHE
SEQRES  17 D  732  TYR GLU ASP TRP GLY GLU ASN MET VAL SER LYS SER THR
SEQRES  18 D  732  PRO VAL LEU CYS VAL LEU ASP ILE GLU SER GLY ASN ILE
SEQRES  19 D  732  SER VAL LEU GLU GLY VAL PRO GLU SER VAL SER PRO GLY
SEQRES  20 D  732  GLN ALA PHE TRP ALA PRO GLY ASP THR GLY VAL VAL PHE
SEQRES  21 D  732  VAL GLY TRP TRP HIS GLU PRO PHE ARG LEU GLY ILE ARG
SEQRES  22 D  732  PHE CYS THR ASN ARG ARG SER ALA LEU TYR TYR VAL ASP
SEQRES  23 D  732  LEU THR GLY GLY LYS CYS GLU LEU LEU SER ASP GLU SER
SEQRES  24 D  732  VAL ALA VAL THR SER PRO ARG LEU SER PRO ASP GLN CYS
SEQRES  25 D  732  ARG ILE VAL TYR LEU ARG PHE PRO SER LEU VAL PRO HIS
SEQRES  26 D  732  GLN GLN CYS GLY GLN LEU CYS LEU TYR ASP TRP TYR THR
SEQRES  27 D  732  ARG VAL THR SER VAL VAL VAL ASP ILE VAL PRO ARG GLN
SEQRES  28 D  732  LEU GLY GLU ASP PHE SER GLY ILE TYR CYS SER LEU LEU
SEQRES  29 D  732  PRO LEU GLY CYS TRP SER ALA ASP SER GLN ARG VAL VAL
SEQRES  30 D  732  PHE ASP SER PRO GLN ARG SER ARG GLN ASP LEU PHE ALA
SEQRES  31 D  732  VAL ASP THR GLN MET GLY SER VAL THR SER LEU THR ALA
SEQRES  32 D  732  GLY GLY SER GLY GLY SER TRP LYS LEU LEU THR ILE ASP
SEQRES  33 D  732  ARG ASP LEU MET VAL VAL GLN PHE SER THR PRO SER VAL
SEQRES  34 D  732  PRO PRO SER LEU LYS VAL GLY PHE LEU PRO PRO ALA GLY
SEQRES  35 D  732  LYS GLU GLN ALA VAL SER TRP VAL SER LEU GLU GLU ALA
SEQRES  36 D  732  GLU PRO PHE PRO ASP ILE SER TRP SER ILE ARG VAL LEU
SEQRES  37 D  732  GLN PRO PRO PRO GLN GLN GLU HIS VAL GLN TYR ALA GLY
SEQRES  38 D  732  LEU ASP PHE GLU ALA ILE LEU LEU GLN PRO SER ASN SER
SEQRES  39 D  732  PRO GLU LYS THR GLN VAL PRO MET VAL VAL MET PRO HIS
SEQRES  40 D  732  GLY GLY PRO HIS SER SER PHE VAL THR ALA TRP MET LEU
SEQRES  41 D  732  PHE PRO ALA MET LEU CYS LYS MET GLY PHE ALA VAL LEU
SEQRES  42 D  732  LEU VAL ASN TYR ARG GLY SER THR GLY PHE GLY GLN ASP
SEQRES  43 D  732  SER ILE LEU SER LEU PRO GLY ASN VAL GLY HIS GLN ASP
SEQRES  44 D  732  VAL LYS ASP VAL GLN PHE ALA VAL GLU GLN VAL LEU GLN
SEQRES  45 D  732  GLU GLU HIS PHE ASP ALA GLY ARG VAL ALA LEU MET GLY
SEQRES  46 D  732  GLY SER HIS GLY GLY PHE LEU SER CYS HIS LEU ILE GLY
SEQRES  47 D  732  GLN TYR PRO GLU THR TYR SER ALA CYS VAL VAL ARG ASN
SEQRES  48 D  732  PRO VAL ILE ASN ILE ALA SER MET MET GLY SER THR ASP
SEQRES  49 D  732  ILE PRO ASP TRP CYS MET VAL GLU ALA GLY PHE SER TYR
SEQRES  50 D  732  SER SER ASP CYS LEU PRO ASP LEU SER VAL TRP ALA ALA
SEQRES  51 D  732  MET LEU ASP LYS SER PRO ILE LYS TYR ALA PRO GLN VAL
SEQRES  52 D  732  LYS THR PRO LEU LEU LEU MET LEU GLY GLN GLU ASP ARG
SEQRES  53 D  732  ARG VAL PRO PHE LYS GLN GLY MET GLU TYR TYR ARG VAL
SEQRES  54 D  732  LEU LYS ALA ARG ASN VAL PRO VAL ARG LEU LEU LEU TYR
SEQRES  55 D  732  PRO LYS SER THR HIS ALA LEU SER GLU VAL GLU VAL GLU
SEQRES  56 D  732  SER ASP SER PHE MET ASN ALA VAL LEU TRP LEU CYS THR
SEQRES  57 D  732  HIS LEU GLY SER
HELIX    1 AA1 GLU A    9  SER A   21  1                                  13
HELIX    2 AA2 LEU A  135  GLU A  139  1                                   5
HELIX    3 AA3 PRO A  253  ASP A  255  5                                   3
HELIX    4 AA4 MET A  519  LYS A  527  1                                   9
HELIX    5 AA5 GLY A  544  LEU A  549  1                                   6
HELIX    6 AA6 GLN A  558  LEU A  571  1                                  14
HELIX    7 AA7 SER A  587  TYR A  600  1                                  14
HELIX    8 AA8 ASN A  615  MET A  620  1                                   6
HELIX    9 AA9 PRO A  626  GLY A  634  1                                   9
HELIX   10 AB1 ASP A  644  SER A  655  1                                  12
HELIX   11 AB2 PHE A  680  ARG A  693  1                                  14
HELIX   12 AB3 GLU A  711  GLY A  731  1                                  21
HELIX   13 AB4 PRO B   10  SER B   21  1                                  12
HELIX   14 AB5 LEU B  135  GLU B  139  1                                   5
HELIX   15 AB6 PRO B  253  ASP B  255  5                                   3
HELIX   16 AB7 MET B  519  LYS B  527  1                                   9
HELIX   17 AB8 GLY B  544  LEU B  551  1                                   8
HELIX   18 AB9 GLN B  558  LEU B  571  1                                  14
HELIX   19 AC1 SER B  587  TYR B  600  1                                  14
HELIX   20 AC2 ASN B  615  SER B  622  1                                   8
HELIX   21 AC3 PRO B  626  GLY B  634  1                                   9
HELIX   22 AC4 ASP B  644  SER B  655  1                                  12
HELIX   23 AC5 TYR B  659  VAL B  663  5                                   5
HELIX   24 AC6 PHE B  680  ARG B  693  1                                  14
HELIX   25 AC7 GLU B  711  LEU B  730  1                                  20
HELIX   26 AC8 PRO C   10  SER C   21  1                                  12
HELIX   27 AC9 LEU C  135  GLU C  139  1                                   5
HELIX   28 AD1 PRO C  253  ASP C  255  5                                   3
HELIX   29 AD2 PRO C  471  GLU C  475  5                                   5
HELIX   30 AD3 MET C  519  LYS C  527  1                                   9
HELIX   31 AD4 GLY C  544  LEU C  551  1                                   8
HELIX   32 AD5 HIS C  557  GLN C  572  1                                  16
HELIX   33 AD6 HIS C  588  TYR C  600  1                                  13
HELIX   34 AD7 ASN C  615  MET C  620  1                                   6
HELIX   35 AD8 PRO C  626  GLY C  634  1                                   9
HELIX   36 AD9 ASP C  644  LYS C  654  1                                  11
HELIX   37 AE1 SER C  655  VAL C  663  5                                   9
HELIX   38 AE2 PHE C  680  ARG C  693  1                                  14
HELIX   39 AE3 GLU C  711  GLY C  731  1                                  21
HELIX   40 AE4 PRO D   10  SER D   21  1                                  12
HELIX   41 AE5 LEU D  135  GLU D  139  1                                   5
HELIX   42 AE6 PRO D  253  ASP D  255  5                                   3
HELIX   43 AE7 PRO D  471  GLU D  475  5                                   5
HELIX   44 AE8 MET D  519  LYS D  527  1                                   9
HELIX   45 AE9 GLY D  544  LEU D  551  1                                   8
HELIX   46 AF1 HIS D  557  GLU D  573  1                                  17
HELIX   47 AF2 HIS D  588  TYR D  600  1                                  13
HELIX   48 AF3 ASN D  615  SER D  622  1                                   8
HELIX   49 AF4 PRO D  626  GLY D  634  1                                   9
HELIX   50 AF5 ASP D  644  SER D  655  1                                  12
HELIX   51 AF6 PRO D  656  VAL D  663  5                                   8
HELIX   52 AF7 PHE D  680  ARG D  693  1                                  14
HELIX   53 AF8 GLU D  711  LEU D  730  1                                  20
SHEET    1 AA1 4 ALA A  25  LEU A  31  0
SHEET    2 AA1 4 ARG A  42  ASP A  54 -1  O  GLU A  49   N  ALA A  28
SHEET    3 AA1 4 GLU A  59  HIS A  71 -1  O  GLU A  59   N  ASP A  54
SHEET    4 AA1 4 VAL A  76  PRO A  81 -1  O  GLY A  80   N  LEU A  68
SHEET    1 AA2 4 VAL A  35  THR A  36  0
SHEET    2 AA2 4 ARG A  42  ASP A  54 -1  O  TYR A  43   N  VAL A  35
SHEET    3 AA2 4 GLU A  59  HIS A  71 -1  O  GLU A  59   N  ASP A  54
SHEET    4 AA2 4 VAL A  86  THR A  88 -1  O  THR A  88   N  ARG A  62
SHEET    1 AA3 4 GLU A  91  GLU A  96  0
SHEET    2 AA3 4 MET A 102  LYS A 108 -1  O  ALA A 104   N  ARG A  95
SHEET    3 AA3 4 GLN A 119  GLU A 125 -1  O  GLU A 122   N  VAL A 105
SHEET    4 AA3 4 ARG A 128  ASN A 134 -1  O  LYS A 131   N  VAL A 123
SHEET    1 AA4 4 LEU A 153  TRP A 155  0
SHEET    2 AA4 4 HIS A 161  ASP A 167 -1  O  LEU A 163   N  SER A 154
SHEET    3 AA4 4 PRO A 222  ASP A 228 -1  O  CYS A 225   N  TYR A 164
SHEET    4 AA4 4 ILE A 234  VAL A 236 -1  O  SER A 235   N  VAL A 226
SHEET    1 AA5 2 ALA A 173  GLU A 174  0
SHEET    2 AA5 2 ILE A 201  LYS A 202  1  O  ILE A 201   N  GLU A 174
SHEET    1 AA6 4 VAL A 244  TRP A 251  0
SHEET    2 AA6 4 GLY A 257  TRP A 264 -1  O  VAL A 259   N  PHE A 250
SHEET    3 AA6 4 SER A 280  ASP A 286 -1  O  VAL A 285   N  VAL A 258
SHEET    4 AA6 4 GLU A 293  LEU A 294 -1  O  GLU A 293   N  TYR A 284
SHEET    1 AA7 4 ALA A 301  LEU A 307  0
SHEET    2 AA7 4 ARG A 313  PHE A 319 -1  O  PHE A 319   N  ALA A 301
SHEET    3 AA7 4 GLN A 330  ASP A 335 -1  O  TYR A 334   N  ILE A 314
SHEET    4 AA7 4 VAL A 340  VAL A 345 -1  O  VAL A 344   N  LEU A 331
SHEET    1 AA8 3 ARG A 375  GLN A 382  0
SHEET    2 AA8 3 ARG A 385  ASP A 392 -1  O  VAL A 391   N  VAL A 376
SHEET    3 AA8 3 VAL A 398  SER A 400 -1  O  THR A 399   N  ALA A 390
SHEET    1 AA9 4 SER A 409  ASP A 416  0
SHEET    2 AA9 4 LEU A 419  SER A 425 -1  O  VAL A 421   N  THR A 414
SHEET    3 AA9 4 LEU A 433  PHE A 437 -1  O  LYS A 434   N  VAL A 422
SHEET    4 AA9 4 TRP A 449  GLU A 453 -1  O  VAL A 450   N  VAL A 435
SHEET    1 AB1 8 ILE A 461  LEU A 468  0
SHEET    2 AB1 8 PHE A 484  PRO A 491 -1  O  PHE A 484   N  LEU A 468
SHEET    3 AB1 8 ALA A 531  ASN A 536 -1  O  VAL A 532   N  LEU A 489
SHEET    4 AB1 8 MET A 502  PRO A 506  1  N  VAL A 503   O  LEU A 533
SHEET    5 AB1 8 VAL A 581  MET A 584  1  O  ALA A 582   N  VAL A 504
SHEET    6 AB1 8 ALA A 606  ARG A 610  1  O  ALA A 606   N  LEU A 583
SHEET    7 AB1 8 LEU A 667  GLY A 672  1  O  LEU A 668   N  VAL A 609
SHEET    8 AB1 8 VAL A 697  TYR A 702  1  O  ARG A 698   N  LEU A 669
SHEET    1 AB2 4 ALA B  25  LEU B  31  0
SHEET    2 AB2 4 ARG B  42  ASP B  54 -1  O  GLU B  49   N  ALA B  28
SHEET    3 AB2 4 GLU B  59  HIS B  71 -1  O  PHE B  63   N  TRP B  50
SHEET    4 AB2 4 VAL B  76  PRO B  81 -1  O  GLY B  80   N  LEU B  68
SHEET    1 AB3 4 VAL B  35  THR B  36  0
SHEET    2 AB3 4 ARG B  42  ASP B  54 -1  O  TYR B  43   N  VAL B  35
SHEET    3 AB3 4 GLU B  59  HIS B  71 -1  O  PHE B  63   N  TRP B  50
SHEET    4 AB3 4 VAL B  86  THR B  88 -1  O  THR B  88   N  ARG B  62
SHEET    1 AB4 4 GLU B  91  GLU B  96  0
SHEET    2 AB4 4 MET B 102  LYS B 108 -1  O  ALA B 104   N  ARG B  95
SHEET    3 AB4 4 GLN B 119  GLU B 125 -1  O  PHE B 120   N  ARG B 107
SHEET    4 AB4 4 ARG B 128  ASN B 134 -1  O  ARG B 128   N  GLU B 125
SHEET    1 AB5 4 LEU B 153  TRP B 155  0
SHEET    2 AB5 4 HIS B 161  ASP B 167 -1  O  LEU B 163   N  SER B 154
SHEET    3 AB5 4 PRO B 222  ASP B 228 -1  O  CYS B 225   N  TYR B 164
SHEET    4 AB5 4 ILE B 234  VAL B 236 -1  O  SER B 235   N  VAL B 226
SHEET    1 AB6 2 ALA B 173  GLU B 174  0
SHEET    2 AB6 2 ILE B 201  LYS B 202  1  O  ILE B 201   N  GLU B 174
SHEET    1 AB7 4 VAL B 244  TRP B 251  0
SHEET    2 AB7 4 GLY B 257  TRP B 264 -1  O  VAL B 259   N  PHE B 250
SHEET    3 AB7 4 SER B 280  ASP B 286 -1  O  VAL B 285   N  VAL B 258
SHEET    4 AB7 4 GLU B 293  LEU B 294 -1  O  GLU B 293   N  TYR B 284
SHEET    1 AB8 4 ALA B 301  LEU B 307  0
SHEET    2 AB8 4 ARG B 313  PHE B 319 -1  O  LEU B 317   N  THR B 303
SHEET    3 AB8 4 GLN B 330  ASP B 335 -1  O  CYS B 332   N  TYR B 316
SHEET    4 AB8 4 VAL B 340  VAL B 343 -1  O  SER B 342   N  LEU B 333
SHEET    1 AB9 3 ARG B 375  PRO B 381  0
SHEET    2 AB9 3 GLN B 386  ASP B 392 -1  O  PHE B 389   N  PHE B 378
SHEET    3 AB9 3 VAL B 398  SER B 400 -1  O  THR B 399   N  ALA B 390
SHEET    1 AC1 4 SER B 409  ASP B 416  0
SHEET    2 AC1 4 LEU B 419  SER B 425 -1  O  VAL B 421   N  THR B 414
SHEET    3 AC1 4 LEU B 433  PHE B 437 -1  O  LYS B 434   N  VAL B 422
SHEET    4 AC1 4 TRP B 449  GLU B 453 -1  O  VAL B 450   N  VAL B 435
SHEET    1 AC2 5 ILE B 461  LEU B 468  0
SHEET    2 AC2 5 PHE B 484  PRO B 491 -1  O  PHE B 484   N  LEU B 468
SHEET    3 AC2 5 ALA B 531  ASN B 536 -1  O  LEU B 534   N  ILE B 487
SHEET    4 AC2 5 VAL B 500  PRO B 506  1  N  MET B 505   O  LEU B 533
SHEET    5 AC2 5 PHE B 576  LEU B 583  1  O  ALA B 582   N  VAL B 504
SHEET    1 AC3 4 GLY B 585  GLY B 586  0
SHEET    2 AC3 4 CYS B 607  ARG B 610  1  O  VAL B 608   N  GLY B 585
SHEET    3 AC3 4 LEU B 667  GLY B 672  1  O  LEU B 668   N  VAL B 609
SHEET    4 AC3 4 VAL B 697  TYR B 702  1  O  ARG B 698   N  LEU B 669
SHEET    1 AC4 4 ALA C  25  LEU C  31  0
SHEET    2 AC4 4 ARG C  42  ASP C  54 -1  O  THR C  51   N  ALA C  25
SHEET    3 AC4 4 GLU C  59  HIS C  71 -1  O  VAL C  69   N  ARG C  44
SHEET    4 AC4 4 VAL C  76  PRO C  81 -1  O  GLY C  80   N  LEU C  68
SHEET    1 AC5 4 VAL C  35  THR C  36  0
SHEET    2 AC5 4 ARG C  42  ASP C  54 -1  O  TYR C  43   N  VAL C  35
SHEET    3 AC5 4 GLU C  59  HIS C  71 -1  O  VAL C  69   N  ARG C  44
SHEET    4 AC5 4 VAL C  86  THR C  88 -1  O  THR C  88   N  ARG C  62
SHEET    1 AC6 4 GLU C  91  GLU C  96  0
SHEET    2 AC6 4 MET C 102  LYS C 108 -1  O  ALA C 104   N  ARG C  95
SHEET    3 AC6 4 GLN C 119  GLU C 125 -1  O  PHE C 120   N  ARG C 107
SHEET    4 AC6 4 ARG C 128  ASN C 134 -1  O  LYS C 131   N  VAL C 123
SHEET    1 AC7 4 LEU C 153  TRP C 155  0
SHEET    2 AC7 4 HIS C 161  ASP C 167 -1  O  LEU C 163   N  SER C 154
SHEET    3 AC7 4 PRO C 222  ASP C 228 -1  O  CYS C 225   N  TYR C 164
SHEET    4 AC7 4 ILE C 234  VAL C 236 -1  O  SER C 235   N  VAL C 226
SHEET    1 AC8 2 ALA C 173  GLU C 174  0
SHEET    2 AC8 2 ILE C 201  LYS C 202  1  O  ILE C 201   N  GLU C 174
SHEET    1 AC9 3 VAL C 244  PRO C 246  0
SHEET    2 AC9 3 GLY C 257  TRP C 264 -1  O  TRP C 263   N  SER C 245
SHEET    3 AC9 3 PHE C 250  TRP C 251 -1  N  PHE C 250   O  VAL C 259
SHEET    1 AD1 4 VAL C 244  PRO C 246  0
SHEET    2 AD1 4 GLY C 257  TRP C 264 -1  O  TRP C 263   N  SER C 245
SHEET    3 AD1 4 SER C 280  ASP C 286 -1  O  VAL C 285   N  VAL C 258
SHEET    4 AD1 4 GLU C 293  LEU C 294 -1  O  GLU C 293   N  TYR C 284
SHEET    1 AD2 4 ALA C 301  LEU C 307  0
SHEET    2 AD2 4 ARG C 313  PHE C 319 -1  O  PHE C 319   N  ALA C 301
SHEET    3 AD2 4 GLN C 330  ASP C 335 -1  O  CYS C 332   N  TYR C 316
SHEET    4 AD2 4 THR C 341  VAL C 343 -1  O  SER C 342   N  LEU C 333
SHEET    1 AD3 3 ARG C 375  GLN C 382  0
SHEET    2 AD3 3 ARG C 385  ASP C 392 -1  O  PHE C 389   N  PHE C 378
SHEET    3 AD3 3 VAL C 398  SER C 400 -1  O  THR C 399   N  ALA C 390
SHEET    1 AD4 4 SER C 409  ASP C 416  0
SHEET    2 AD4 4 LEU C 419  SER C 425 -1  O  VAL C 421   N  THR C 414
SHEET    3 AD4 4 LEU C 433  PHE C 437 -1  O  GLY C 436   N  MET C 420
SHEET    4 AD4 4 VAL C 450  GLU C 453 -1  O  VAL C 450   N  VAL C 435
SHEET    1 AD5 8 ILE C 461  LEU C 468  0
SHEET    2 AD5 8 PHE C 484  PRO C 491 -1  O  ALA C 486   N  ARG C 466
SHEET    3 AD5 8 ALA C 531  ASN C 536 -1  O  LEU C 534   N  ILE C 487
SHEET    4 AD5 8 VAL C 500  PRO C 506  1  N  MET C 505   O  LEU C 533
SHEET    5 AD5 8 PHE C 576  GLY C 585  1  O  ALA C 582   N  VAL C 504
SHEET    6 AD5 8 ALA C 606  VAL C 609  1  O  VAL C 608   N  GLY C 585
SHEET    7 AD5 8 LEU C 667  GLY C 672  1  O  LEU C 668   N  VAL C 609
SHEET    8 AD5 8 VAL C 697  TYR C 702  1  O  ARG C 698   N  LEU C 669
SHEET    1 AD6 4 ALA D  25  LEU D  31  0
SHEET    2 AD6 4 ARG D  42  ASP D  54 -1  O  GLU D  49   N  SER D  27
SHEET    3 AD6 4 GLU D  59  HIS D  71 -1  O  ARG D  65   N  THR D  48
SHEET    4 AD6 4 VAL D  76  PRO D  81 -1  O  PHE D  78   N  PHE D  70
SHEET    1 AD7 4 VAL D  35  THR D  36  0
SHEET    2 AD7 4 ARG D  42  ASP D  54 -1  O  TYR D  43   N  VAL D  35
SHEET    3 AD7 4 GLU D  59  HIS D  71 -1  O  ARG D  65   N  THR D  48
SHEET    4 AD7 4 VAL D  86  THR D  88 -1  O  THR D  88   N  ARG D  62
SHEET    1 AD8 4 GLU D  91  GLU D  96  0
SHEET    2 AD8 4 MET D 102  LYS D 108 -1  O  LEU D 106   N  LEU D  92
SHEET    3 AD8 4 GLN D 119  GLU D 125 -1  O  PHE D 120   N  ARG D 107
SHEET    4 AD8 4 ARG D 128  ASN D 134 -1  O  LYS D 131   N  VAL D 123
SHEET    1 AD9 4 LEU D 153  TRP D 155  0
SHEET    2 AD9 4 HIS D 161  ASP D 167 -1  O  LEU D 163   N  SER D 154
SHEET    3 AD9 4 PRO D 222  ASP D 228 -1  O  CYS D 225   N  TYR D 164
SHEET    4 AD9 4 ILE D 234  VAL D 236 -1  O  SER D 235   N  VAL D 226
SHEET    1 AE1 2 ALA D 173  GLU D 174  0
SHEET    2 AE1 2 ILE D 201  LYS D 202  1  O  ILE D 201   N  GLU D 174
SHEET    1 AE2 4 VAL D 244  TRP D 251  0
SHEET    2 AE2 4 GLY D 257  TRP D 264 -1  O  VAL D 259   N  PHE D 250
SHEET    3 AE2 4 SER D 280  ASP D 286 -1  O  TYR D 283   N  PHE D 260
SHEET    4 AE2 4 GLU D 293  LEU D 294 -1  O  GLU D 293   N  TYR D 284
SHEET    1 AE3 4 ALA D 301  LEU D 307  0
SHEET    2 AE3 4 ARG D 313  PHE D 319 -1  O  LEU D 317   N  THR D 303
SHEET    3 AE3 4 GLN D 330  ASP D 335 -1  O  CYS D 332   N  TYR D 316
SHEET    4 AE3 4 THR D 341  VAL D 345 -1  O  VAL D 344   N  LEU D 331
SHEET    1 AE4 3 ARG D 375  GLN D 382  0
SHEET    2 AE4 3 ARG D 385  ASP D 392 -1  O  ARG D 385   N  GLN D 382
SHEET    3 AE4 3 VAL D 398  SER D 400 -1  O  THR D 399   N  ALA D 390
SHEET    1 AE5 4 SER D 409  ASP D 416  0
SHEET    2 AE5 4 LEU D 419  SER D 425 -1  O  VAL D 421   N  THR D 414
SHEET    3 AE5 4 LEU D 433  PHE D 437 -1  O  GLY D 436   N  MET D 420
SHEET    4 AE5 4 TRP D 449  GLU D 453 -1  O  VAL D 450   N  VAL D 435
SHEET    1 AE6 8 ILE D 461  LEU D 468  0
SHEET    2 AE6 8 PHE D 484  PRO D 491 -1  O  PHE D 484   N  LEU D 468
SHEET    3 AE6 8 ALA D 531  ASN D 536 -1  O  LEU D 534   N  ILE D 487
SHEET    4 AE6 8 MET D 502  PRO D 506  1  N  VAL D 503   O  ALA D 531
SHEET    5 AE6 8 VAL D 581  SER D 587  1  O  ALA D 582   N  MET D 502
SHEET    6 AE6 8 VAL D 608  PRO D 612  1  O  ARG D 610   N  SER D 587
SHEET    7 AE6 8 LEU D 667  GLY D 672  1  O  LEU D 668   N  VAL D 609
SHEET    8 AE6 8 VAL D 697  TYR D 702  1  O  ARG D 698   N  LEU D 669
CISPEP   1 GLU A  266    PRO A  267          0         1.73
CISPEP   2 GLY A  509    PRO A  510          0         9.84
CISPEP   3 GLU B  266    PRO B  267          0         0.82
CISPEP   4 GLY B  509    PRO B  510          0         0.73
CISPEP   5 GLU C  266    PRO C  267          0         0.37
CISPEP   6 GLY C  509    PRO C  510          0         9.47
CISPEP   7 GLU D  266    PRO D  267          0         0.18
CISPEP   8 GLY D  509    PRO D  510          0         7.77
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      1.000000  0.000000  0.000000        0.00000
SCALE2      0.000000  1.000000  0.000000        0.00000
SCALE3      0.000000  0.000000  1.000000        0.00000
TER    5339      SER A 732
TER   10699      SER B 732
TER   16060      SER C 732
TER   21413      SER D 732
MASTER      513    0    0   53  168    0    0    621163    4    0  228
END