longtext: 7sfm-pdb

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HEADER    HYDROLASE                               04-OCT-21   7SFM
TITLE     MYCOBACTERIUM TUBERCULOSIS HIP1 CRYSTAL STRUCTURE
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: HIP1;
COMPND   3 CHAIN: A;
COMPND   4 SYNONYM: PROTEASE;
COMPND   5 EC: 3.4.-.-,3.4.14.-;
COMPND   6 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: MYCOBACTERIUM TUBERCULOSIS;
SOURCE   3 ORGANISM_TAXID: 1773;
SOURCE   4 GENE: TAP;
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 562
KEYWDS    MTB, AEBSF, TB, TUBERCULOSIS, SERINE HYDROLASE, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    D.A.OSTROV,D.LI
REVDAT   1   24-AUG-22 7SFM    0
JRNL        AUTH   D.A.OSTROV,D.LI,N.GOLDFARB
JRNL        TITL   MYCOBACTERIUM TUBERCULOSIS HIP1 CRYSTAL STRUCTURE
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   2
REMARK   2 RESOLUTION.    2.15 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX 1.13_2998
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : ML
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.15
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 29.46
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.340
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.5
REMARK   3   NUMBER OF REFLECTIONS             : 44549
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.176
REMARK   3   R VALUE            (WORKING SET) : 0.175
REMARK   3   FREE R VALUE                     : 0.205
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.480
REMARK   3   FREE R VALUE TEST SET COUNT      : 1996
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 29.4600 -  5.1713    1.00     3222   151  0.1900 0.1971
REMARK   3     2  5.1713 -  4.1081    1.00     3116   143  0.1572 0.1970
REMARK   3     3  4.1081 -  3.5899    1.00     3069   148  0.1538 0.1656
REMARK   3     4  3.5899 -  3.2621    1.00     3059   140  0.1645 0.1721
REMARK   3     5  3.2621 -  3.0285    1.00     3047   143  0.1778 0.1976
REMARK   3     6  3.0285 -  2.8501    1.00     3021   144  0.1776 0.2165
REMARK   3     7  2.8501 -  2.7075    0.99     3024   144  0.1796 0.2362
REMARK   3     8  2.7075 -  2.5897    0.99     3022   142  0.1760 0.2058
REMARK   3     9  2.5897 -  2.4901    0.99     3013   143  0.1802 0.2211
REMARK   3    10  2.4901 -  2.4042    0.99     3007   139  0.1787 0.2347
REMARK   3    11  2.4042 -  2.3290    0.99     2962   139  0.1887 0.2372
REMARK   3    12  2.3290 -  2.2625    0.99     3009   137  0.1920 0.2361
REMARK   3    13  2.2625 -  2.2030    0.99     2996   141  0.1892 0.2547
REMARK   3    14  2.2030 -  2.1492    0.99     2986   142  0.2035 0.2525
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL
REMARK   3   SOLVENT RADIUS     : 1.11
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.190
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 19.490
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 24.75
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :   NULL           NULL
REMARK   3   ANGLE     :   NULL           NULL
REMARK   3   CHIRALITY :   NULL           NULL
REMARK   3   PLANARITY :   NULL           NULL
REMARK   3   DIHEDRAL  :   NULL           NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 7SFM COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 05-OCT-21.
REMARK 100 THE DEPOSITION ID IS D_1000259306.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 09-OCT-14
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : NULL
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : NSLS
REMARK 200  BEAMLINE                       : X6A
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9436
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 210
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200  DATA SCALING SOFTWARE          : XDS
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 44555
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.149
REMARK 200  RESOLUTION RANGE LOW       (A) : 29.464
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.0
REMARK 200  DATA REDUNDANCY                : 1.100
REMARK 200  R MERGE                    (I) : NULL
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 17.0000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.15
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.23
REMARK 200  COMPLETENESS FOR SHELL     (%) : NULL
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL
REMARK 200  R MERGE FOR SHELL          (I) : NULL
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHENIX
REMARK 200 STARTING MODEL: 5UGQ
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 68.86
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 3.95
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 30% PEG 3350, 0.1M SODIUM ACETATE PH
REMARK 280  5.6, 0.2 M AMMONIUM SULFATE AND 10% GLYCEROL, VAPOR DIFFUSION,
REMARK 280  HANGING DROP, TEMPERATURE 298K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 31 2 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -Y,X-Y,Z+1/3
REMARK 290       3555   -X+Y,-X,Z+2/3
REMARK 290       4555   Y,X,-Z
REMARK 290       5555   X-Y,-Y,-Z+2/3
REMARK 290       6555   -X,-X+Y,-Z+1/3
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -0.500000 -0.866025  0.000000        0.00000
REMARK 290   SMTRY2   2  0.866025 -0.500000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       42.60067
REMARK 290   SMTRY1   3 -0.500000  0.866025  0.000000        0.00000
REMARK 290   SMTRY2   3 -0.866025 -0.500000  0.000000        0.00000
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000       85.20133
REMARK 290   SMTRY1   4 -0.500000  0.866025  0.000000        0.00000
REMARK 290   SMTRY2   4  0.866025  0.500000  0.000000        0.00000
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   5  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   5  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   5  0.000000  0.000000 -1.000000       85.20133
REMARK 290   SMTRY1   6 -0.500000 -0.866025  0.000000        0.00000
REMARK 290   SMTRY2   6 -0.866025  0.500000  0.000000        0.00000
REMARK 290   SMTRY3   6  0.000000  0.000000 -1.000000       42.60067
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     SER A    29
REMARK 465     SER A    30
REMARK 465     ASN A    31
REMARK 465     PRO A    32
REMARK 465     GLN A    33
REMARK 465     VAL A    34
REMARK 465     LYS A    35
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    ALA A  19       67.50    -29.96
REMARK 500    ALA A 117     -114.37     53.45
REMARK 500    CYS A 125      -53.13   -122.44
REMARK 500    SER A 200     -109.01     41.49
REMARK 500    ARG A 290       74.07   -118.33
REMARK 500    THR A 463      162.43     74.59
REMARK 500    VAL A 464      -19.57   -155.17
REMARK 500
REMARK 500 REMARK: NULL
DBREF1 7SFM A   20   492  UNP                  A0A654TLU9_MYCTX
DBREF2 7SFM A     A0A654TLU9                         46         518
SEQADV 7SFM ALA A   14  UNP  A0A654TLU           EXPRESSION TAG
SEQADV 7SFM ALA A   15  UNP  A0A654TLU           EXPRESSION TAG
SEQADV 7SFM ALA A   16  UNP  A0A654TLU           EXPRESSION TAG
SEQADV 7SFM ALA A   17  UNP  A0A654TLU           EXPRESSION TAG
SEQADV 7SFM LEU A   18  UNP  A0A654TLU           EXPRESSION TAG
SEQADV 7SFM ALA A   19  UNP  A0A654TLU           EXPRESSION TAG
SEQRES   1 A  479  ALA ALA ALA ALA LEU ALA GLN PRO VAL GLU TRP THR PRO
SEQRES   2 A  479  CYS ARG SER SER ASN PRO GLN VAL LYS ILE PRO GLY GLY
SEQRES   3 A  479  ALA LEU CYS GLY LYS LEU ALA VAL PRO VAL ASP TYR ASP
SEQRES   4 A  479  ARG PRO ASP GLY ASP VAL ALA ALA LEU ALA LEU ILE ARG
SEQRES   5 A  479  PHE PRO ALA THR GLY ASP LYS ILE GLY SER LEU VAL ILE
SEQRES   6 A  479  ASN PRO GLY GLY PRO GLY GLU SER GLY ILE GLU ALA ALA
SEQRES   7 A  479  LEU GLY VAL PHE GLN THR LEU PRO LYS ARG VAL HIS GLU
SEQRES   8 A  479  ARG PHE ASP LEU VAL GLY PHE ASP PRO ARG GLY VAL ALA
SEQRES   9 A  479  SER SER ARG PRO ALA ILE TRP CYS ASN SER ASP ALA ASP
SEQRES  10 A  479  ASN ASP ARG LEU ARG ALA GLU PRO GLN VAL ASP TYR SER
SEQRES  11 A  479  ARG GLU GLY VAL ALA HIS ILE GLU ASN GLU THR LYS GLN
SEQRES  12 A  479  PHE VAL GLY ARG CYS VAL ASP LYS MSE GLY LYS ASN PHE
SEQRES  13 A  479  LEU ALA HIS VAL GLY THR VAL ASN VAL ALA LYS ASP LEU
SEQRES  14 A  479  ASP ALA ILE ARG ALA ALA LEU GLY ASP ASP LYS LEU THR
SEQRES  15 A  479  TYR LEU GLY TYR SER TYR GLY THR ARG ILE GLY SER ALA
SEQRES  16 A  479  TYR ALA GLU GLU PHE PRO GLN ARG VAL ARG ALA MSE ILE
SEQRES  17 A  479  LEU ASP GLY ALA VAL ASP PRO ASN ALA ASP PRO ILE GLU
SEQRES  18 A  479  ALA GLU LEU ARG GLN ALA LYS GLY PHE GLN ASP ALA PHE
SEQRES  19 A  479  ASN ASN TYR ALA ALA ASP CYS ALA LYS ASN ALA GLY CYS
SEQRES  20 A  479  PRO LEU GLY ALA ASP PRO ALA LYS ALA VAL GLU VAL TYR
SEQRES  21 A  479  HIS SER LEU VAL ASP PRO LEU VAL ASP PRO ASP ASN PRO
SEQRES  22 A  479  ARG ILE SER ARG PRO ALA ARG THR LYS ASP PRO ARG GLY
SEQRES  23 A  479  LEU SER TYR SER ASP ALA ILE VAL GLY THR ILE MSE ALA
SEQRES  24 A  479  LEU TYR SER PRO ASN LEU TRP GLN HIS LEU THR ASP GLY
SEQRES  25 A  479  LEU SER GLU LEU VAL ASP ASN ARG GLY ASP THR LEU LEU
SEQRES  26 A  479  ALA LEU ALA ASP MSE TYR MSE ARG ARG ASP SER HIS GLY
SEQRES  27 A  479  ARG TYR ASN ASN SER GLY ASP ALA ARG VAL ALA ILE ASN
SEQRES  28 A  479  CYS VAL ASP GLN PRO PRO VAL THR ASP ARG ASP LYS VAL
SEQRES  29 A  479  ILE ASP GLU ASP ARG ARG ALA ARG GLU ILE ALA PRO PHE
SEQRES  30 A  479  MSE SER TYR GLY LYS PHE THR GLY ASP ALA PRO LEU GLY
SEQRES  31 A  479  THR CYS ALA PHE TRP PRO VAL PRO PRO THR SER GLN PRO
SEQRES  32 A  479  HIS ALA VAL SER ALA PRO GLY LEU VAL PRO THR VAL VAL
SEQRES  33 A  479  VAL SER THR THR HIS ASP PRO ALA THR PRO TYR LYS ALA
SEQRES  34 A  479  GLY VAL ASP LEU ALA ASN GLN LEU ARG GLY SER LEU LEU
SEQRES  35 A  479  THR PHE ASP GLY THR GLN HIS THR VAL VAL PHE GLN GLY
SEQRES  36 A  479  ASP SER CYS ILE ASP GLU TYR VAL THR ALA TYR LEU ILE
SEQRES  37 A  479  GLY GLY THR THR PRO PRO SER GLY ALA LYS CYS
MODRES 7SFM MSE A  165  MET  MODIFIED RESIDUE
MODRES 7SFM MSE A  220  MET  MODIFIED RESIDUE
MODRES 7SFM MSE A  311  MET  MODIFIED RESIDUE
MODRES 7SFM MSE A  343  MET  MODIFIED RESIDUE
MODRES 7SFM MSE A  345  MET  MODIFIED RESIDUE
MODRES 7SFM MSE A  391  MET  MODIFIED RESIDUE
HET    MSE  A 165       8
HET    MSE  A 220       8
HET    MSE  A 311       8
HET    MSE  A 343       8
HET    MSE  A 345       8
HET    MSE  A 391       8
HET    GOL  A 501       6
HET    GOL  A 502       6
HET    GOL  A 503       6
HET    GOL  A 504       6
HET    ACT  A 505       4
HETNAM     MSE SELENOMETHIONINE
HETNAM     GOL GLYCEROL
HETNAM     ACT ACETATE ION
HETSYN     GOL GLYCERIN; PROPANE-1,2,3-TRIOL
FORMUL   1  MSE    6(C5 H11 N O2 SE)
FORMUL   2  GOL    4(C3 H8 O3)
FORMUL   6  ACT    C2 H3 O2 1-
FORMUL   7  HOH   *466(H2 O)
HELIX    1 AA1 SER A   86  LEU A   98  1                                  13
HELIX    2 AA2 PRO A   99  ARG A  105  1                                   7
HELIX    3 AA3 SER A  127  ALA A  136  1                                  10
HELIX    4 AA4 SER A  143  GLY A  166  1                                  24
HELIX    5 AA5 GLY A  166  HIS A  172  1                                   7
HELIX    6 AA6 GLY A  174  LEU A  189  1                                  16
HELIX    7 AA7 TYR A  201  PHE A  213  1                                  13
HELIX    8 AA8 ASP A  231  LYS A  256  1                                  26
HELIX    9 AA9 ASP A  265  ALA A  267  5                                   3
HELIX   10 AB1 LYS A  268  ASP A  278  1                                  11
HELIX   11 AB2 PRO A  279  VAL A  281  5                                   3
HELIX   12 AB3 SER A  301  LEU A  313  1                                  13
HELIX   13 AB4 TYR A  314  ASN A  317  5                                   4
HELIX   14 AB5 LEU A  318  ASP A  331  1                                  14
HELIX   15 AB6 GLY A  334  ARG A  346  1                                  13
HELIX   16 AB7 ASN A  355  ASP A  367  1                                  13
HELIX   17 AB8 ASP A  373  ALA A  388  1                                  16
HELIX   18 AB9 PRO A  389  SER A  392  5                                   4
HELIX   19 AC1 GLY A  403  TRP A  408  5                                   6
HELIX   20 AC2 PRO A  439  ARG A  451  1                                  13
HELIX   21 AC3 ASP A  469  GLY A  483  1                                  15
SHEET    1 AA110 THR A  25  PRO A  26  0
SHEET    2 AA110 LEU A  41  PRO A  48 -1  O  CYS A  42   N  THR A  25
SHEET    3 AA110 VAL A  58  PHE A  66 -1  O  LEU A  61   N  LEU A  45
SHEET    4 AA110 PHE A 106  PHE A 111 -1  O  LEU A 108   N  PHE A  66
SHEET    5 AA110 GLY A  74  ASN A  79  1  N  LEU A  76   O  ASP A 107
SHEET    6 AA110 LEU A 194  TYR A 199  1  O  THR A 195   N  VAL A  77
SHEET    7 AA110 VAL A 217  ASP A 223  1  O  ILE A 221   N  GLY A 198
SHEET    8 AA110 VAL A 428  THR A 432  1  O  VAL A 428   N  LEU A 222
SHEET    9 AA110 SER A 453  PHE A 457  1  O  SER A 453   N  VAL A 429
SHEET   10 AA110 LYS A 491  CYS A 492  1  O  CYS A 492   N  THR A 456
SSBOND   1 CYS A   27    CYS A   42                          1555   1555  2.05
SSBOND   2 CYS A  125    CYS A  161                          1555   1555  2.04
SSBOND   3 CYS A  254    CYS A  260                          1555   1555  2.06
SSBOND   4 CYS A  365    CYS A  405                          1555   1555  2.03
SSBOND   5 CYS A  471    CYS A  492                          1555   1555  2.08
LINK         C   LYS A 164                 N   MSE A 165     1555   1555  1.33
LINK         C   MSE A 165                 N   GLY A 166     1555   1555  1.33
LINK         C   ALA A 219                 N   MSE A 220     1555   1555  1.33
LINK         C   MSE A 220                 N   ILE A 221     1555   1555  1.33
LINK         C   ILE A 310                 N   MSE A 311     1555   1555  1.33
LINK         C   MSE A 311                 N   ALA A 312     1555   1555  1.33
LINK         C   ASP A 342                 N   MSE A 343     1555   1555  1.33
LINK         C   MSE A 343                 N   TYR A 344     1555   1555  1.34
LINK         C   TYR A 344                 N   MSE A 345     1555   1555  1.34
LINK         C   MSE A 345                 N   ARG A 346     1555   1555  1.34
LINK         C   PHE A 390                 N   MSE A 391     1555   1555  1.33
LINK         C   MSE A 391                 N   SER A 392     1555   1555  1.32
CISPEP   1 GLY A   82    PRO A   83          0        -1.84
CISPEP   2 ARG A  120    PRO A  121          0        -4.79
CRYST1  104.891  104.891  127.802  90.00  90.00 120.00 P 31 2 1      6
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.009534  0.005504  0.000000        0.00000
SCALE2      0.000000  0.011009  0.000000        0.00000
SCALE3      0.000000  0.000000  0.007825        0.00000
TER    3559      CYS A 492
MASTER      249    0   11   21   10    0    0    6 4052    1   98   37
END