longtext: 7w44-pdb

content
HEADER    HYDROLASE                               26-NOV-21   7W44
TITLE     COMPLEX STRUCTURE OF A LEAF-BRANCH COMPOST CUTINASE VARIANT LCC
TITLE    2 ICCG_RIP
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: LEAF-BRANCH COMPOST CUTINASE;
COMPND   3 CHAIN: A, B;
COMPND   4 SYNONYM: LC-CUTINASE,LCC,PET-DIGESTING ENZYME,POLY(ETHYLENE
COMPND   5 TEREPHTHALATE) HYDROLASE,PET HYDROLASE,PETASE;
COMPND   6 EC: 3.1.1.74,3.1.1.101;
COMPND   7 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: UNIDENTIFIED PROKARYOTIC ORGANISM;
SOURCE   3 ORGANISM_TAXID: 2725;
SOURCE   4 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3);
SOURCE   5 EXPRESSION_SYSTEM_TAXID: 469008;
SOURCE   6 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;
SOURCE   7 EXPRESSION_SYSTEM_PLASMID: PET46EK /LIC
KEYWDS    PLASTIC DEGRADATION, MUTANT, CATALYSIS, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    D.NIU,W.ZENG,J.W.HUANG,C.C.CHEN,W.D.LIU,R.T.GUO
REVDAT   1   09-MAR-22 7W44    0
JRNL        AUTH   W.ZENG,X.LI,Y.YANG,J.MIN,J.-W.HUANG,W.LIU,D.NIU,X.YANG,
JRNL        AUTH 2 X.HAN,L.ZHANG,L.DAI,C.-C.CHEN,R.-T.GUO
JRNL        TITL   SUBSTRATE-BINDING MODE OF A THERMOPHILIC PET HYDROLASE AND
JRNL        TITL 2 ENGINEERING THE ENZYME TO ENHANCE THE HYDROLYTIC EFFICACY.
JRNL        REF    ACS CATALYSIS                 V.  12  3033 2022
JRNL        REFN                   ESSN 2155-5435
JRNL        DOI    10.1021/ACSCATAL.1C05800
REMARK   2
REMARK   2 RESOLUTION.    1.85 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.8.0267
REMARK   3   AUTHORS     : MURSHUDOV,SKUBAK,LEBEDEV,PANNU,STEINER,
REMARK   3               : NICHOLLS,WINN,LONG,VAGIN
REMARK   3
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.85
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 24.94
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0.000
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.0
REMARK   3   NUMBER OF REFLECTIONS             : 47432
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.153
REMARK   3   R VALUE            (WORKING SET) : 0.151
REMARK   3   FREE R VALUE                     : 0.187
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.000
REMARK   3   FREE R VALUE TEST SET COUNT      : 2483
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 1.85
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 1.90
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 3417
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 97.74
REMARK   3   BIN R VALUE           (WORKING SET) : 0.2210
REMARK   3   BIN FREE R VALUE SET COUNT          : 174
REMARK   3   BIN FREE R VALUE                    : 0.2700
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 3890
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 13
REMARK   3   SOLVENT ATOMS            : 615
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 15.71
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : 0.89000
REMARK   3    B22 (A**2) : -1.06000
REMARK   3    B33 (A**2) : 0.17000
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : 0.00000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): 0.112
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.109
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.074
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 2.519
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.966
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.951
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A):  4025 ; 0.011 ; 0.013
REMARK   3   BOND LENGTHS OTHERS               (A):  3705 ; 0.001 ; 0.014
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES):  5512 ; 1.645 ; 1.647
REMARK   3   BOND ANGLES OTHERS          (DEGREES):  8499 ; 1.495 ; 1.570
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):   520 ; 7.011 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   201 ;28.608 ;20.348
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):   572 ;10.607 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):    34 ;19.485 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):   542 ; 0.083 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A):  4667 ; 0.010 ; 0.020
REMARK   3   GENERAL PLANES OTHERS             (A):   989 ; 0.001 ; 0.020
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN ANGLE OTHER ATOMS   (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN ANGLE OTHER ATOMS   (A**2):  NULL ;  NULL ;  NULL
REMARK   3   LONG RANGE B REFINED ATOMS     (A**2):  NULL ;  NULL ;  NULL
REMARK   3   LONG RANGE B OTHER ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : MASK
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.20
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE RIDING
REMARK   3  POSITIONS U VALUES : REFINED INDIVIDUALLY
REMARK   4
REMARK   4 7W44 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 29-NOV-21.
REMARK 100 THE DEPOSITION ID IS D_1300025940.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 01-OCT-21
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 6.5
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : N
REMARK 200  RADIATION SOURCE               : LIQUID ANODE
REMARK 200  BEAMLINE                       : NULL
REMARK 200  X-RAY GENERATOR MODEL          : BRUKER METALJET
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.34138
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : PIXEL
REMARK 200  DETECTOR MANUFACTURER          : BRUKER PHOTON III
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : SAINT
REMARK 200  DATA SCALING SOFTWARE          : AIMLESS 0.6.3
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 49376
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.850
REMARK 200  RESOLUTION RANGE LOW       (A) : 24.940
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.7
REMARK 200  DATA REDUNDANCY                : 6.800
REMARK 200  R MERGE                    (I) : 0.09800
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 12.7000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.85
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.89
REMARK 200  COMPLETENESS FOR SHELL     (%) : 100.0
REMARK 200  DATA REDUNDANCY IN SHELL       : 4.70
REMARK 200  R MERGE FOR SHELL          (I) : 0.46000
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: 7DS7
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 52.03
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.56
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.1 M MES PH 6.5, 12% W/V PEG 20,000,
REMARK 280  VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 298K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: C 2 2 21
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,-Y,Z+1/2
REMARK 290       3555   -X,Y,-Z+1/2
REMARK 290       4555   X,-Y,-Z
REMARK 290       5555   X+1/2,Y+1/2,Z
REMARK 290       6555   -X+1/2,-Y+1/2,Z+1/2
REMARK 290       7555   -X+1/2,Y+1/2,-Z+1/2
REMARK 290       8555   X+1/2,-Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       59.11800
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       59.11800
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   5  1.000000  0.000000  0.000000       32.28350
REMARK 290   SMTRY2   5  0.000000  1.000000  0.000000       76.63500
REMARK 290   SMTRY3   5  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   6 -1.000000  0.000000  0.000000       32.28350
REMARK 290   SMTRY2   6  0.000000 -1.000000  0.000000       76.63500
REMARK 290   SMTRY3   6  0.000000  0.000000  1.000000       59.11800
REMARK 290   SMTRY1   7 -1.000000  0.000000  0.000000       32.28350
REMARK 290   SMTRY2   7  0.000000  1.000000  0.000000       76.63500
REMARK 290   SMTRY3   7  0.000000  0.000000 -1.000000       59.11800
REMARK 290   SMTRY1   8  1.000000  0.000000  0.000000       32.28350
REMARK 290   SMTRY2   8  0.000000 -1.000000  0.000000       76.63500
REMARK 290   SMTRY3   8  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 375
REMARK 375 SPECIAL POSITION
REMARK 375 THE FOLLOWING ATOMS ARE FOUND TO BE WITHIN 0.15 ANGSTROMS
REMARK 375 OF A SYMMETRY RELATED ATOM AND ARE ASSUMED TO BE ON SPECIAL
REMARK 375 POSITIONS.
REMARK 375
REMARK 375 ATOM RES CSSEQI
REMARK 375      HOH B 625  LIES ON A SPECIAL POSITION.
REMARK 375      HOH B 633  LIES ON A SPECIAL POSITION.
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A    35
REMARK 465     GLN A   293
REMARK 465     ALA A   294
REMARK 465     GLY A   295
REMARK 465     ALA A   296
REMARK 465     GLY A   297
REMARK 465     ALA A   298
REMARK 465     GLY A   299
REMARK 465     ALA A   300
REMARK 465     GLY A   301
REMARK 465     ALA A   302
REMARK 465     GLY A   303
REMARK 465     MET B    35
REMARK 465     GLN B   293
REMARK 465     ALA B   294
REMARK 465     GLY B   295
REMARK 465     ALA B   296
REMARK 465     GLY B   297
REMARK 465     ALA B   298
REMARK 465     GLY B   299
REMARK 465     ALA B   300
REMARK 465     GLY B   301
REMARK 465     ALA B   302
REMARK 465     GLY B   303
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    THR A  96       -4.45     72.87
REMARK 500    SER A 145       18.20   -146.70
REMARK 500    SER A 165     -122.64     66.39
REMARK 500    THR A 188       55.71     37.62
REMARK 500    HIS A 218      -84.29   -123.02
REMARK 500    SER B 165     -122.88     66.88
REMARK 500    THR B 188       61.51     32.21
REMARK 500    HIS B 218      -87.59   -126.21
REMARK 500
REMARK 500 REMARK: NULL
REMARK 525
REMARK 525 SOLVENT
REMARK 525
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 525 NUMBER; I=INSERTION CODE):
REMARK 525
REMARK 525  M RES CSSEQI
REMARK 525    HOH A 838        DISTANCE =  5.81 ANGSTROMS
REMARK 525    HOH A 839        DISTANCE =  6.91 ANGSTROMS
REMARK 525    HOH A 840        DISTANCE = 11.59 ANGSTROMS
DBREF  7W44 A   36   293  UNP    G9BY57   PETH_UNKP       36    293
DBREF  7W44 B   36   293  UNP    G9BY57   PETH_UNKP       36    293
SEQADV 7W44 MET A   35  UNP  G9BY57              INITIATING METHIONINE
SEQADV 7W44 ARG A   59  UNP  G9BY57    ALA    59 CONFLICT
SEQADV 7W44 ILE A   63  UNP  G9BY57    VAL    63 CONFLICT
SEQADV 7W44 GLY A  127  UNP  G9BY57    TYR   127 CONFLICT
SEQADV 7W44 CYS A  238  UNP  G9BY57    ASP   238 CONFLICT
SEQADV 7W44 ILE A  243  UNP  G9BY57    PHE   243 CONFLICT
SEQADV 7W44 PRO A  248  UNP  G9BY57    ASN   248 CONFLICT
SEQADV 7W44 CYS A  283  UNP  G9BY57    SER   283 CONFLICT
SEQADV 7W44 ALA A  294  UNP  G9BY57              EXPRESSION TAG
SEQADV 7W44 GLY A  295  UNP  G9BY57              EXPRESSION TAG
SEQADV 7W44 ALA A  296  UNP  G9BY57              EXPRESSION TAG
SEQADV 7W44 GLY A  297  UNP  G9BY57              EXPRESSION TAG
SEQADV 7W44 ALA A  298  UNP  G9BY57              EXPRESSION TAG
SEQADV 7W44 GLY A  299  UNP  G9BY57              EXPRESSION TAG
SEQADV 7W44 ALA A  300  UNP  G9BY57              EXPRESSION TAG
SEQADV 7W44 GLY A  301  UNP  G9BY57              EXPRESSION TAG
SEQADV 7W44 ALA A  302  UNP  G9BY57              EXPRESSION TAG
SEQADV 7W44 GLY A  303  UNP  G9BY57              EXPRESSION TAG
SEQADV 7W44 MET B   35  UNP  G9BY57              INITIATING METHIONINE
SEQADV 7W44 ARG B   59  UNP  G9BY57    ALA    59 CONFLICT
SEQADV 7W44 ILE B   63  UNP  G9BY57    VAL    63 CONFLICT
SEQADV 7W44 GLY B  127  UNP  G9BY57    TYR   127 CONFLICT
SEQADV 7W44 CYS B  238  UNP  G9BY57    ASP   238 CONFLICT
SEQADV 7W44 ILE B  243  UNP  G9BY57    PHE   243 CONFLICT
SEQADV 7W44 PRO B  248  UNP  G9BY57    ASN   248 CONFLICT
SEQADV 7W44 CYS B  283  UNP  G9BY57    SER   283 CONFLICT
SEQADV 7W44 ALA B  294  UNP  G9BY57              EXPRESSION TAG
SEQADV 7W44 GLY B  295  UNP  G9BY57              EXPRESSION TAG
SEQADV 7W44 ALA B  296  UNP  G9BY57              EXPRESSION TAG
SEQADV 7W44 GLY B  297  UNP  G9BY57              EXPRESSION TAG
SEQADV 7W44 ALA B  298  UNP  G9BY57              EXPRESSION TAG
SEQADV 7W44 GLY B  299  UNP  G9BY57              EXPRESSION TAG
SEQADV 7W44 ALA B  300  UNP  G9BY57              EXPRESSION TAG
SEQADV 7W44 GLY B  301  UNP  G9BY57              EXPRESSION TAG
SEQADV 7W44 ALA B  302  UNP  G9BY57              EXPRESSION TAG
SEQADV 7W44 GLY B  303  UNP  G9BY57              EXPRESSION TAG
SEQRES   1 A  269  MET SER ASN PRO TYR GLN ARG GLY PRO ASN PRO THR ARG
SEQRES   2 A  269  SER ALA LEU THR ALA ASP GLY PRO PHE SER VAL ARG THR
SEQRES   3 A  269  TYR THR ILE SER ARG LEU SER VAL SER GLY PHE GLY GLY
SEQRES   4 A  269  GLY VAL ILE TYR TYR PRO THR GLY THR SER LEU THR PHE
SEQRES   5 A  269  GLY GLY ILE ALA MET SER PRO GLY TYR THR ALA ASP ALA
SEQRES   6 A  269  SER SER LEU ALA TRP LEU GLY ARG ARG LEU ALA SER HIS
SEQRES   7 A  269  GLY PHE VAL VAL LEU VAL ILE ASN THR ASN SER ARG PHE
SEQRES   8 A  269  ASP GLY PRO ASP SER ARG ALA SER GLN LEU SER ALA ALA
SEQRES   9 A  269  LEU ASN TYR LEU ARG THR SER SER PRO SER ALA VAL ARG
SEQRES  10 A  269  ALA ARG LEU ASP ALA ASN ARG LEU ALA VAL ALA GLY HIS
SEQRES  11 A  269  SER MET GLY GLY GLY GLY THR LEU ARG ILE ALA GLU GLN
SEQRES  12 A  269  ASN PRO SER LEU LYS ALA ALA VAL PRO LEU THR PRO TRP
SEQRES  13 A  269  HIS THR ASP LYS THR PHE ASN THR SER VAL PRO VAL LEU
SEQRES  14 A  269  ILE VAL GLY ALA GLU ALA ASP THR VAL ALA PRO VAL SER
SEQRES  15 A  269  GLN HIS ALA ILE PRO PHE TYR GLN ASN LEU PRO SER THR
SEQRES  16 A  269  THR PRO LYS VAL TYR VAL GLU LEU CYS ASN ALA SER HIS
SEQRES  17 A  269  ILE ALA PRO ASN SER PRO ASN ALA ALA ILE SER VAL TYR
SEQRES  18 A  269  THR ILE SER TRP MET LYS LEU TRP VAL ASP ASN ASP THR
SEQRES  19 A  269  ARG TYR ARG GLN PHE LEU CYS ASN VAL ASN ASP PRO ALA
SEQRES  20 A  269  LEU CYS ASP PHE ARG THR ASN ASN ARG HIS CYS GLN ALA
SEQRES  21 A  269  GLY ALA GLY ALA GLY ALA GLY ALA GLY
SEQRES   1 B  269  MET SER ASN PRO TYR GLN ARG GLY PRO ASN PRO THR ARG
SEQRES   2 B  269  SER ALA LEU THR ALA ASP GLY PRO PHE SER VAL ARG THR
SEQRES   3 B  269  TYR THR ILE SER ARG LEU SER VAL SER GLY PHE GLY GLY
SEQRES   4 B  269  GLY VAL ILE TYR TYR PRO THR GLY THR SER LEU THR PHE
SEQRES   5 B  269  GLY GLY ILE ALA MET SER PRO GLY TYR THR ALA ASP ALA
SEQRES   6 B  269  SER SER LEU ALA TRP LEU GLY ARG ARG LEU ALA SER HIS
SEQRES   7 B  269  GLY PHE VAL VAL LEU VAL ILE ASN THR ASN SER ARG PHE
SEQRES   8 B  269  ASP GLY PRO ASP SER ARG ALA SER GLN LEU SER ALA ALA
SEQRES   9 B  269  LEU ASN TYR LEU ARG THR SER SER PRO SER ALA VAL ARG
SEQRES  10 B  269  ALA ARG LEU ASP ALA ASN ARG LEU ALA VAL ALA GLY HIS
SEQRES  11 B  269  SER MET GLY GLY GLY GLY THR LEU ARG ILE ALA GLU GLN
SEQRES  12 B  269  ASN PRO SER LEU LYS ALA ALA VAL PRO LEU THR PRO TRP
SEQRES  13 B  269  HIS THR ASP LYS THR PHE ASN THR SER VAL PRO VAL LEU
SEQRES  14 B  269  ILE VAL GLY ALA GLU ALA ASP THR VAL ALA PRO VAL SER
SEQRES  15 B  269  GLN HIS ALA ILE PRO PHE TYR GLN ASN LEU PRO SER THR
SEQRES  16 B  269  THR PRO LYS VAL TYR VAL GLU LEU CYS ASN ALA SER HIS
SEQRES  17 B  269  ILE ALA PRO ASN SER PRO ASN ALA ALA ILE SER VAL TYR
SEQRES  18 B  269  THR ILE SER TRP MET LYS LEU TRP VAL ASP ASN ASP THR
SEQRES  19 B  269  ARG TYR ARG GLN PHE LEU CYS ASN VAL ASN ASP PRO ALA
SEQRES  20 B  269  LEU CYS ASP PHE ARG THR ASN ASN ARG HIS CYS GLN ALA
SEQRES  21 B  269  GLY ALA GLY ALA GLY ALA GLY ALA GLY
HET    EDO  A 401       4
HET    IMD  B 401       5
HET    EDO  B 402       4
HETNAM     EDO 1,2-ETHANEDIOL
HETNAM     IMD IMIDAZOLE
HETSYN     EDO ETHYLENE GLYCOL
FORMUL   3  EDO    2(C2 H6 O2)
FORMUL   4  IMD    C3 H5 N2 1+
FORMUL   6  HOH   *615(H2 O)
HELIX    1 AA1 ARG A   47  ALA A   52  5                                   6
HELIX    2 AA2 SER A   64  VAL A   68  5                                   5
HELIX    3 AA3 ASP A   98  SER A  101  5                                   4
HELIX    4 AA4 LEU A  102  HIS A  112  1                                  11
HELIX    5 AA5 GLY A  127  SER A  145  1                                  19
HELIX    6 AA6 PRO A  147  ALA A  152  1                                   6
HELIX    7 AA7 SER A  165  ASN A  178  1                                  14
HELIX    8 AA8 HIS A  218  LEU A  226  1                                   9
HELIX    9 AA9 ILE A  243  SER A  247  5                                   5
HELIX   10 AB1 ASN A  249  ASP A  265  1                                  17
HELIX   11 AB2 ASP A  267  LEU A  274  5                                   8
HELIX   12 AB3 ARG B   47  ALA B   52  5                                   6
HELIX   13 AB4 SER B   64  VAL B   68  5                                   5
HELIX   14 AB5 ASP B   98  SER B  101  5                                   4
HELIX   15 AB6 LEU B  102  HIS B  112  1                                  11
HELIX   16 AB7 GLY B  127  SER B  145  1                                  19
HELIX   17 AB8 PRO B  147  ARG B  153  1                                   7
HELIX   18 AB9 SER B  165  ASN B  178  1                                  14
HELIX   19 AC1 HIS B  218  LEU B  226  1                                   9
HELIX   20 AC2 ILE B  243  SER B  247  5                                   5
HELIX   21 AC3 ASN B  249  ASP B  265  1                                  17
HELIX   22 AC4 ASP B  267  LEU B  274  5                                   8
SHEET    1 AA1 6 VAL A  58  ILE A  63  0
SHEET    2 AA1 6 GLY A  74  PRO A  79 -1  O  GLY A  74   N  ILE A  63
SHEET    3 AA1 6 VAL A 115  ILE A 119 -1  O  VAL A 116   N  TYR A  77
SHEET    4 AA1 6 PHE A  86  SER A  92  1  N  ILE A  89   O  VAL A 115
SHEET    5 AA1 6 LEU A 154  HIS A 164  1  O  ASP A 155   N  PHE A  86
SHEET    6 AA1 6 ALA A 184  LEU A 187  1  O  LEU A 187   N  GLY A 163
SHEET    1 AA2 3 VAL A 202  ALA A 207  0
SHEET    2 AA2 3 LYS A 232  LEU A 237  1  O  VAL A 235   N  GLY A 206
SHEET    3 AA2 3 LEU A 282  THR A 287 -1  O  ARG A 286   N  TYR A 234
SHEET    1 AA3 6 SER B  57  ILE B  63  0
SHEET    2 AA3 6 GLY B  74  THR B  80 -1  O  ILE B  76   N  TYR B  61
SHEET    3 AA3 6 PHE B 114  ILE B 119 -1  O  VAL B 116   N  TYR B  77
SHEET    4 AA3 6 PHE B  86  SER B  92  1  N  ILE B  89   O  LEU B 117
SHEET    5 AA3 6 LEU B 154  HIS B 164  1  O  ASP B 155   N  PHE B  86
SHEET    6 AA3 6 ALA B 184  LEU B 187  1  O  LEU B 187   N  GLY B 163
SHEET    1 AA4 3 VAL B 202  ALA B 207  0
SHEET    2 AA4 3 LYS B 232  LEU B 237  1  O  VAL B 235   N  GLY B 206
SHEET    3 AA4 3 LEU B 282  THR B 287 -1  O  CYS B 283   N  GLU B 236
SSBOND   1 CYS A  238    CYS A  283                          1555   1555  2.08
SSBOND   2 CYS A  275    CYS A  292                          1555   1555  2.04
SSBOND   3 CYS B  238    CYS B  283                          1555   1555  2.10
SSBOND   4 CYS B  275    CYS B  292                          1555   1555  2.12
CRYST1   64.567  153.270  118.236  90.00  90.00  90.00 C 2 2 21     16
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.015488  0.000000  0.000000        0.00000
SCALE2      0.000000  0.006524  0.000000        0.00000
SCALE3      0.000000  0.000000  0.008458        0.00000
TER    1952      CYS A 292
TER    3906      CYS B 292
MASTER      337    0    3   22   18    0    0    6 4518    2   21   42
END