longtext: 7w66-pdb

content
HEADER    HYDROLASE                               01-DEC-21   7W66
TITLE     CRYSTAL STRUCTURE OF A PSH1 MUTANT IN COMPLEX WITH LIGAND
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: PSH1;
COMPND   3 CHAIN: A, B;
COMPND   4 ENGINEERED: YES;
COMPND   5 MUTATION: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: UNIDENTIFIED;
SOURCE   3 ORGANISM_TAXID: 32644;
SOURCE   4 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3);
SOURCE   5 EXPRESSION_SYSTEM_TAXID: 469008;
SOURCE   6 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;
SOURCE   7 EXPRESSION_SYSTEM_PLASMID: PET-28A
KEYWDS    ALPHA/BETA DEHYDROGENASE, PLASTIC DEGRADATION, THERMO-STABLE,
KEYWDS   2 HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    J.GAO,P.LARA,Z.S.LI,X.HAN,R.WEI,W.D.LIU
REVDAT   1   14-SEP-22 7W66    0
JRNL        AUTH   L.PFAFF,J.GAO,Z.LI,A.JACKERING,G.WEBER,J.MICAN,Y.CHEN,
JRNL        AUTH 2 W.DONG,X.HAN,C.G.FEILER,Y.F.AO,C.P.S.BADENHORST,D.BEDNAR,
JRNL        AUTH 3 G.J.PALM,M.LAMMERS,J.DAMBORSKY,B.STRODEL,W.LIU,
JRNL        AUTH 4 U.T.BORNSCHEUER,R.WEI
JRNL        TITL   MULTIPLE SUBSTRATE BINDING MODE-GUIDED ENGINEERING OF A
JRNL        TITL 2 THERMOPHILIC PET HYDROLASE.
JRNL        REF    ACS CATALYSIS                 V.  12  9790 2022
JRNL        REFN                   ESSN 2155-5435
JRNL        PMID   35966606
JRNL        DOI    10.1021/ACSCATAL.2C02275
REMARK   2
REMARK   2 RESOLUTION.    1.96 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX 1.19.2_4158
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : ML
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.96
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 30.00
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.340
REMARK   3   COMPLETENESS FOR RANGE        (%) : 94.2
REMARK   3   NUMBER OF REFLECTIONS             : 73934
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.200
REMARK   3   R VALUE            (WORKING SET) : 0.198
REMARK   3   FREE R VALUE                     : 0.229
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.020
REMARK   3   FREE R VALUE TEST SET COUNT      : 3709
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 30.0000 -  4.2200    0.99     7391   402  0.1779 0.1908
REMARK   3     2  4.2200 -  3.3500    1.00     7465   395  0.1628 0.1941
REMARK   3     3  3.3500 -  2.9300    1.00     7412   386  0.1923 0.2216
REMARK   3     4  2.9300 -  2.6900    1.00     6371   337  0.2032 0.2345
REMARK   3     5  2.6500 -  2.4700    0.99     7131   370  0.2090 0.2583
REMARK   3     6  2.4700 -  2.3200    1.00     7438   395  0.2124 0.2686
REMARK   3     7  2.3200 -  2.2100    0.63     4703   249  0.2361 0.2743
REMARK   3     8  2.2100 -  2.1100    1.00     7453   393  0.2278 0.2723
REMARK   3     9  2.1100 -  2.0300    1.00     7430   394  0.2558 0.2903
REMARK   3    10  2.0300 -  1.9600    1.00     7431   388  0.2886 0.3290
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL
REMARK   3   SOLVENT RADIUS     : 1.11
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.240
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 24.450
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 24.24
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 25.60
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :   NULL           NULL
REMARK   3   ANGLE     :   NULL           NULL
REMARK   3   CHIRALITY :   NULL           NULL
REMARK   3   PLANARITY :   NULL           NULL
REMARK   3   DIHEDRAL  :   NULL           NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 7W66 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 08-DEC-21.
REMARK 100 THE DEPOSITION ID IS D_1300026051.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 04-JAN-20
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 5.0
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : SSRF
REMARK 200  BEAMLINE                       : BL17U1
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.0
REMARK 200  MONOCHROMATOR                  : GRAPHITE
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 315R
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200  DATA SCALING SOFTWARE          : HKL-2000
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 74685
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.960
REMARK 200  RESOLUTION RANGE LOW       (A) : 30.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 94.4
REMARK 200  DATA REDUNDANCY                : 6.200
REMARK 200  R MERGE                    (I) : NULL
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 13.0000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.96
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.06
REMARK 200  COMPLETENESS FOR SHELL     (%) : 99.9
REMARK 200  DATA REDUNDANCY IN SHELL       : 5.20
REMARK 200  R MERGE FOR SHELL          (I) : NULL
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 2.500
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: 7NEI
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 50.76
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.50
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 21% PEG 6000, 0.1M CITRIC ACID, 35%
REMARK 280  MPD, PH 5.0, VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 295K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X+1/2,-Y,Z+1/2
REMARK 290       3555   -X,Y+1/2,-Z+1/2
REMARK 290       4555   X+1/2,-Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       52.92250
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       47.94050
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       27.81400
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       47.94050
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       52.92250
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       27.81400
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     GLU A     1
REMARK 465     GLU B     1
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    SER A 130     -124.41     61.37
REMARK 500    HIS A 184      -90.40   -128.06
REMARK 500    THR A 255       41.07    -85.11
REMARK 500    SER B 130     -122.67     57.69
REMARK 500    ASN B 143       91.53   -161.19
REMARK 500    ALA B 179       70.99   -119.10
REMARK 500    HIS B 184      -90.40   -121.98
REMARK 500    PRO B 242     -156.89    -80.93
REMARK 500
REMARK 500 REMARK: NULL
REMARK 525
REMARK 525 SOLVENT
REMARK 525
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 525 NUMBER; I=INSERTION CODE):
REMARK 525
REMARK 525  M RES CSSEQI
REMARK 525    HOH B 580        DISTANCE =  5.90 ANGSTROMS
REMARK 525    HOH B 581        DISTANCE =  6.00 ANGSTROMS
DBREF  7W66 A    1   258  PDB    7W66     7W66             1    258
DBREF  7W66 B    1   258  PDB    7W66     7W66             1    258
SEQRES   1 A  258  GLU ASN PRO TYR GLU ARG GLY PRO ASP PRO THR GLU SER
SEQRES   2 A  258  SER ILE GLU ALA VAL ARG GLY PRO PHE ALA VAL ALA GLN
SEQRES   3 A  258  THR THR VAL SER ARG LEU GLN ALA ASP GLY PHE GLY GLY
SEQRES   4 A  258  GLY THR ILE TYR TYR PRO THR ASP THR SER GLN GLY THR
SEQRES   5 A  258  PHE GLY ALA VAL ALA ILE SER PRO GLY PHE THR ALA GLY
SEQRES   6 A  258  GLN GLU SER ILE ALA TRP LEU GLY PRO ARG ILE ALA SER
SEQRES   7 A  258  GLN GLY PHE VAL VAL ILE THR ILE ASP THR ILE THR ARG
SEQRES   8 A  258  LEU ASP GLN PRO ASP SER ARG GLY ARG GLN LEU GLN ALA
SEQRES   9 A  258  ALA LEU ASP HIS LEU ARG THR ASN SER VAL VAL ARG ASN
SEQRES  10 A  258  ARG ILE ASP PRO ASN ARG MET ALA VAL MET GLY HIS SER
SEQRES  11 A  258  MET GLY GLY GLY GLY ALA LEU SER ALA ALA ALA ASN ASN
SEQRES  12 A  258  THR SER LEU GLU ALA ALA ILE PRO LEU GLN GLY TRP HIS
SEQRES  13 A  258  THR ARG LYS ASN TRP SER SER VAL ARG THR PRO THR LEU
SEQRES  14 A  258  VAL VAL GLY ALA GLN LEU ASP THR ILE ALA PRO VAL SER
SEQRES  15 A  258  SER HIS SER GLU ALA PHE TYR ASN SER LEU PRO SER ASP
SEQRES  16 A  258  LEU ASP LYS ALA TYR MET GLU LEU ARG GLY ALA SER HIS
SEQRES  17 A  258  PHE VAL SER ASN THR PRO ASP THR THR THR ALA LYS TYR
SEQRES  18 A  258  SER ILE ALA TRP LEU LYS ARG PHE VAL ASP ASN ASP LEU
SEQRES  19 A  258  ARG TYR GLU GLN PHE LEU CYS PRO ALA PRO ASP ASP PHE
SEQRES  20 A  258  ALA ILE SER GLU TYR ARG ALA THR CYS PRO PHE
SEQRES   1 B  258  GLU ASN PRO TYR GLU ARG GLY PRO ASP PRO THR GLU SER
SEQRES   2 B  258  SER ILE GLU ALA VAL ARG GLY PRO PHE ALA VAL ALA GLN
SEQRES   3 B  258  THR THR VAL SER ARG LEU GLN ALA ASP GLY PHE GLY GLY
SEQRES   4 B  258  GLY THR ILE TYR TYR PRO THR ASP THR SER GLN GLY THR
SEQRES   5 B  258  PHE GLY ALA VAL ALA ILE SER PRO GLY PHE THR ALA GLY
SEQRES   6 B  258  GLN GLU SER ILE ALA TRP LEU GLY PRO ARG ILE ALA SER
SEQRES   7 B  258  GLN GLY PHE VAL VAL ILE THR ILE ASP THR ILE THR ARG
SEQRES   8 B  258  LEU ASP GLN PRO ASP SER ARG GLY ARG GLN LEU GLN ALA
SEQRES   9 B  258  ALA LEU ASP HIS LEU ARG THR ASN SER VAL VAL ARG ASN
SEQRES  10 B  258  ARG ILE ASP PRO ASN ARG MET ALA VAL MET GLY HIS SER
SEQRES  11 B  258  MET GLY GLY GLY GLY ALA LEU SER ALA ALA ALA ASN ASN
SEQRES  12 B  258  THR SER LEU GLU ALA ALA ILE PRO LEU GLN GLY TRP HIS
SEQRES  13 B  258  THR ARG LYS ASN TRP SER SER VAL ARG THR PRO THR LEU
SEQRES  14 B  258  VAL VAL GLY ALA GLN LEU ASP THR ILE ALA PRO VAL SER
SEQRES  15 B  258  SER HIS SER GLU ALA PHE TYR ASN SER LEU PRO SER ASP
SEQRES  16 B  258  LEU ASP LYS ALA TYR MET GLU LEU ARG GLY ALA SER HIS
SEQRES  17 B  258  PHE VAL SER ASN THR PRO ASP THR THR THR ALA LYS TYR
SEQRES  18 B  258  SER ILE ALA TRP LEU LYS ARG PHE VAL ASP ASN ASP LEU
SEQRES  19 B  258  ARG TYR GLU GLN PHE LEU CYS PRO ALA PRO ASP ASP PHE
SEQRES  20 B  258  ALA ILE SER GLU TYR ARG ALA THR CYS PRO PHE
HET    C8X  B 301      18
HETNAM     C8X BIS(2-HYDROXYETHYL) BENZENE-1,4-DICARBOXYLATE
HETSYN     C8X BIS(2-HYDROXYETHYL) TEREPHTHALATE
FORMUL   3  C8X    C12 H14 O6
FORMUL   4  HOH   *363(H2 O)
HELIX    1 AA1 THR A   11  ALA A   17  1                                   7
HELIX    2 AA2 GLY A   65  ALA A   70  5                                   6
HELIX    3 AA3 TRP A   71  SER A   78  1                                   8
HELIX    4 AA4 GLN A   94  ASN A  112  1                                  19
HELIX    5 AA5 SER A  130  ASN A  142  1                                  13
HELIX    6 AA6 HIS A  184  LEU A  192  1                                   9
HELIX    7 AA7 PHE A  209  THR A  213  5                                   5
HELIX    8 AA8 ASP A  215  ASP A  231  1                                  17
HELIX    9 AA9 ASP A  233  LEU A  240  5                                   8
HELIX   10 AB1 THR B   11  ALA B   17  1                                   7
HELIX   11 AB2 GLY B   65  ALA B   70  5                                   6
HELIX   12 AB3 TRP B   71  SER B   78  1                                   8
HELIX   13 AB4 GLN B   94  ARG B  110  1                                  17
HELIX   14 AB5 SER B  130  ASN B  142  1                                  13
HELIX   15 AB6 HIS B  184  LEU B  192  1                                   9
HELIX   16 AB7 PHE B  209  THR B  213  5                                   5
HELIX   17 AB8 ASP B  215  ASP B  231  1                                  17
HELIX   18 AB9 ASP B  233  ARG B  235  5                                   3
HELIX   19 AC1 TYR B  236  CYS B  241  1                                   6
SHEET    1 AA1 6 VAL A  24  VAL A  29  0
SHEET    2 AA1 6 GLY A  40  PRO A  45 -1  O  GLY A  40   N  VAL A  29
SHEET    3 AA1 6 PHE A  81  ILE A  86 -1  O  VAL A  83   N  TYR A  43
SHEET    4 AA1 6 PHE A  53  SER A  59  1  N  VAL A  56   O  VAL A  82
SHEET    5 AA1 6 ILE A 119  HIS A 129  1  O  ASP A 120   N  PHE A  53
SHEET    6 AA1 6 ALA A 148  LEU A 152  1  O  LEU A 152   N  GLY A 128
SHEET    1 AA2 3 THR A 168  ALA A 173  0
SHEET    2 AA2 3 LYS A 198  LEU A 203  1  O  ALA A 199   N  VAL A 170
SHEET    3 AA2 3 ILE A 249  ALA A 254 -1  O  SER A 250   N  GLU A 202
SHEET    1 AA3 6 VAL B  24  VAL B  29  0
SHEET    2 AA3 6 GLY B  40  PRO B  45 -1  O  ILE B  42   N  THR B  27
SHEET    3 AA3 6 PHE B  81  ILE B  86 -1  O  VAL B  83   N  TYR B  43
SHEET    4 AA3 6 PHE B  53  SER B  59  1  N  VAL B  56   O  ILE B  84
SHEET    5 AA3 6 ILE B 119  HIS B 129  1  O  ASP B 120   N  PHE B  53
SHEET    6 AA3 6 ALA B 148  LEU B 152  1  O  LEU B 152   N  GLY B 128
SHEET    1 AA4 3 THR B 168  ALA B 173  0
SHEET    2 AA4 3 LYS B 198  LEU B 203  1  O  MET B 201   N  VAL B 170
SHEET    3 AA4 3 ILE B 249  ALA B 254 -1  O  ARG B 253   N  TYR B 200
SSBOND   1 CYS A  241    CYS A  256                          1555   1555  2.04
SSBOND   2 CYS B  241    CYS B  256                          1555   1555  2.03
CISPEP   1 CYS A  241    PRO A  242          0        -7.97
CISPEP   2 CYS A  256    PRO A  257          0         1.07
CISPEP   3 CYS B  241    PRO B  242          0         0.00
CISPEP   4 CYS B  256    PRO B  257          0        -2.52
CRYST1  105.845   55.628   95.881  90.00  90.00  90.00 P 21 21 21    8
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.009448  0.000000  0.000000        0.00000
SCALE2      0.000000  0.017977  0.000000        0.00000
SCALE3      0.000000  0.000000  0.010430        0.00000
TER    1959      PHE A 258
TER    3918      PHE B 258
MASTER      251    0    1   19   18    0    0    6 4297    2   22   40
END