longtext: 7wol-pdb

content
HEADER    HYDROLASE                               21-JAN-22   7WOL
TITLE     CRYSTAL STRUCTURE OF LIPASE TRLIPB FROM THERMOMOCROBIUM ROSEUM
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: LIPASE;
COMPND   3 CHAIN: A, B;
COMPND   4 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: THERMOMICROBIUM ROSEUM DSM 5159;
SOURCE   3 ORGANISM_TAXID: 309801;
SOURCE   4 STRAIN: ATCC 27502 / DSM 5159 / P-2;
SOURCE   5 GENE: TRD_1687;
SOURCE   6 EXPRESSION_SYSTEM: BACILLUS SUBTILIS;
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 1423
KEYWDS    LIPID DEGRADATION, LIPID METABOLISM, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    L.ZHANG,Y.FANG,Y.SHI,Z.GU,Y.XIN
REVDAT   1   25-JAN-23 7WOL    0
JRNL        AUTH   Y.FANG,Y.XIN,Y.SHI,Z.GU,L.ZHANG
JRNL        TITL   CRYSTAL STRUCTURE OF LIPASE TRLIPB FROM THERMOMOCROBIUM
JRNL        TITL 2 ROSEUM
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   2
REMARK   2 RESOLUTION.    2.00 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.8.0267
REMARK   3   AUTHORS     : MURSHUDOV,SKUBAK,LEBEDEV,PANNU,STEINER,
REMARK   3               : NICHOLLS,WINN,LONG,VAGIN
REMARK   3
REMARK   3    REFINEMENT TARGET : NULL
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.00
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 45.75
REMARK   3   DATA CUTOFF            (SIGMA(F)) : NULL
REMARK   3   COMPLETENESS FOR RANGE        (%) : 100.0
REMARK   3   NUMBER OF REFLECTIONS             : 70744
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : FREE R-VALUE
REMARK   3   FREE R VALUE TEST SET SELECTION  : NULL
REMARK   3   R VALUE     (WORKING + TEST SET) : NULL
REMARK   3   R VALUE            (WORKING SET) : 0.157
REMARK   3   FREE R VALUE                     : 0.186
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.943
REMARK   3   FREE R VALUE TEST SET COUNT      : 3497
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : NULL
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 2.00
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 2.05
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 4911
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 99.98
REMARK   3   BIN R VALUE           (WORKING SET) : 0.2300
REMARK   3   BIN FREE R VALUE SET COUNT          : 270
REMARK   3   BIN FREE R VALUE                    : 0.2310
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 4948
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 110
REMARK   3   SOLVENT ATOMS            : 417
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 39.58
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : -1.71700
REMARK   3    B22 (A**2) : -1.71700
REMARK   3    B33 (A**2) : 3.43300
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : 0.00000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): 0.112
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.108
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.079
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 2.894
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.973
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.962
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A):  5190 ; 0.008 ; 0.013
REMARK   3   BOND LENGTHS OTHERS               (A):  5005 ; 0.001 ; 0.015
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES):  7055 ; 1.454 ; 1.649
REMARK   3   BOND ANGLES OTHERS          (DEGREES): 11461 ; 1.319 ; 1.570
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):   641 ; 6.212 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   298 ;27.203 ;19.799
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):   768 ;12.394 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):    61 ;19.610 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):   639 ; 0.073 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A):  5840 ; 0.007 ; 0.020
REMARK   3   GENERAL PLANES OTHERS             (A):  1218 ; 0.001 ; 0.020
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  1047 ; 0.209 ; 0.200
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):    46 ; 0.259 ; 0.200
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  2484 ; 0.161 ; 0.200
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):   379 ; 0.161 ; 0.200
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  2555 ; 2.593 ; 3.838
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  2554 ; 2.592 ; 3.836
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  3190 ; 3.596 ; 5.741
REMARK   3   MAIN-CHAIN ANGLE OTHER ATOMS   (A**2):  3191 ; 3.596 ; 5.743
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  2635 ; 3.562 ; 4.356
REMARK   3   SIDE-CHAIN BOND OTHER ATOMS    (A**2):  2636 ; 3.561 ; 4.357
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  3862 ; 5.397 ; 6.329
REMARK   3   SIDE-CHAIN ANGLE OTHER ATOMS   (A**2):  3863 ; 5.396 ; 6.331
REMARK   3   LONG RANGE B REFINED ATOMS     (A**2):  NULL ;  NULL ;  NULL
REMARK   3   LONG RANGE B OTHER ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : MASK BULK SOLVENT
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.20
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THEIR
REMARK   3  RIDING POSITIONS
REMARK   4
REMARK   4 7WOL COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ.
REMARK 100 THE DEPOSITION ID IS D_1300026937.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 19-NOV-21
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : NULL
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : SPRING-8
REMARK 200  BEAMLINE                       : BL45XU
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.00000
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : PIXEL
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS PILATUS3 6M
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200  DATA SCALING SOFTWARE          : AIMLESS
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 70819
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.000
REMARK 200  RESOLUTION RANGE LOW       (A) : 45.750
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 100.0
REMARK 200  DATA REDUNDANCY                : 14.40
REMARK 200  R MERGE                    (I) : 0.08200
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 22.8000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.00
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.04
REMARK 200  COMPLETENESS FOR SHELL     (%) : NULL
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL
REMARK 200  R MERGE FOR SHELL          (I) : 0.82100
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: 1LZK
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 64.88
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 3.50
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 1M SUCCINIC ACID,0.1M HEPES,7,1%
REMARK 280  W/VPEG 2000 MME, VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 293K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 43 21 2
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,-Y,Z+1/2
REMARK 290       3555   -Y+1/2,X+1/2,Z+3/4
REMARK 290       4555   Y+1/2,-X+1/2,Z+1/4
REMARK 290       5555   -X+1/2,Y+1/2,-Z+3/4
REMARK 290       6555   X+1/2,-Y+1/2,-Z+1/4
REMARK 290       7555   Y,X,-Z
REMARK 290       8555   -Y,-X,-Z+1/2
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       61.39600
REMARK 290   SMTRY1   3  0.000000 -1.000000  0.000000       64.70100
REMARK 290   SMTRY2   3  1.000000  0.000000  0.000000       64.70100
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000       92.09400
REMARK 290   SMTRY1   4  0.000000  1.000000  0.000000       64.70100
REMARK 290   SMTRY2   4 -1.000000  0.000000  0.000000       64.70100
REMARK 290   SMTRY3   4  0.000000  0.000000  1.000000       30.69800
REMARK 290   SMTRY1   5 -1.000000  0.000000  0.000000       64.70100
REMARK 290   SMTRY2   5  0.000000  1.000000  0.000000       64.70100
REMARK 290   SMTRY3   5  0.000000  0.000000 -1.000000       92.09400
REMARK 290   SMTRY1   6  1.000000  0.000000  0.000000       64.70100
REMARK 290   SMTRY2   6  0.000000 -1.000000  0.000000       64.70100
REMARK 290   SMTRY3   6  0.000000  0.000000 -1.000000       30.69800
REMARK 290   SMTRY1   7  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY2   7  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY3   7  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   8  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY2   8 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY3   8  0.000000  0.000000 -1.000000       61.39600
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 6160 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 24060 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: 18.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A     1
REMARK 465     ALA A   324
REMARK 465     ALA A   325
REMARK 465     LEU A   326
REMARK 465     GLU A   327
REMARK 465     HIS A   328
REMARK 465     HIS A   329
REMARK 465     HIS A   330
REMARK 465     HIS A   331
REMARK 465     HIS A   332
REMARK 465     HIS A   333
REMARK 465     MET B     1
REMARK 465     ALA B    42
REMARK 465     LEU B    43
REMARK 465     ALA B    44
REMARK 465     SER B    45
REMARK 465     LEU B    46
REMARK 465     LEU B    47
REMARK 465     ALA B   324
REMARK 465     ALA B   325
REMARK 465     LEU B   326
REMARK 465     GLU B   327
REMARK 465     HIS B   328
REMARK 465     HIS B   329
REMARK 465     HIS B   330
REMARK 465     HIS B   331
REMARK 465     HIS B   332
REMARK 465     HIS B   333
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    TYR A  95       -4.29     74.94
REMARK 500    SER A 165     -121.89     59.63
REMARK 500    TYR A 193       64.29     27.71
REMARK 500    ILE A 214      -64.09     80.31
REMARK 500    LEU B  39      -71.11    -45.54
REMARK 500    TYR B  95       -4.20     74.85
REMARK 500    TYR B 131      136.40    -40.00
REMARK 500    SER B 165     -122.52     61.26
REMARK 500    TYR B 193       64.06     29.68
REMARK 500    ILE B 214      -62.14     83.19
REMARK 500    ALA B 299       57.81   -145.40
REMARK 500
REMARK 500 REMARK: NULL
DBREF  7WOL A    1   320  UNP    B9L0X7   B9L0X7_THERP     1    320
DBREF  7WOL B    1   320  UNP    B9L0X7   B9L0X7_THERP     1    320
SEQADV 7WOL LYS A  321  UNP  B9L0X7              EXPRESSION TAG
SEQADV 7WOL LEU A  322  UNP  B9L0X7              EXPRESSION TAG
SEQADV 7WOL ALA A  323  UNP  B9L0X7              EXPRESSION TAG
SEQADV 7WOL ALA A  324  UNP  B9L0X7              EXPRESSION TAG
SEQADV 7WOL ALA A  325  UNP  B9L0X7              EXPRESSION TAG
SEQADV 7WOL LEU A  326  UNP  B9L0X7              EXPRESSION TAG
SEQADV 7WOL GLU A  327  UNP  B9L0X7              EXPRESSION TAG
SEQADV 7WOL HIS A  328  UNP  B9L0X7              EXPRESSION TAG
SEQADV 7WOL HIS A  329  UNP  B9L0X7              EXPRESSION TAG
SEQADV 7WOL HIS A  330  UNP  B9L0X7              EXPRESSION TAG
SEQADV 7WOL HIS A  331  UNP  B9L0X7              EXPRESSION TAG
SEQADV 7WOL HIS A  332  UNP  B9L0X7              EXPRESSION TAG
SEQADV 7WOL HIS A  333  UNP  B9L0X7              EXPRESSION TAG
SEQADV 7WOL LYS B  321  UNP  B9L0X7              EXPRESSION TAG
SEQADV 7WOL LEU B  322  UNP  B9L0X7              EXPRESSION TAG
SEQADV 7WOL ALA B  323  UNP  B9L0X7              EXPRESSION TAG
SEQADV 7WOL ALA B  324  UNP  B9L0X7              EXPRESSION TAG
SEQADV 7WOL ALA B  325  UNP  B9L0X7              EXPRESSION TAG
SEQADV 7WOL LEU B  326  UNP  B9L0X7              EXPRESSION TAG
SEQADV 7WOL GLU B  327  UNP  B9L0X7              EXPRESSION TAG
SEQADV 7WOL HIS B  328  UNP  B9L0X7              EXPRESSION TAG
SEQADV 7WOL HIS B  329  UNP  B9L0X7              EXPRESSION TAG
SEQADV 7WOL HIS B  330  UNP  B9L0X7              EXPRESSION TAG
SEQADV 7WOL HIS B  331  UNP  B9L0X7              EXPRESSION TAG
SEQADV 7WOL HIS B  332  UNP  B9L0X7              EXPRESSION TAG
SEQADV 7WOL HIS B  333  UNP  B9L0X7              EXPRESSION TAG
SEQRES   1 A  333  MET SER VAL PHE ALA ARG LEU ASP PRO GLU LEU ALA ALA
SEQRES   2 A  333  ALA LEU ARG GLU ILE PRO GLU GLU PHE LEU LEU ASP LEU
SEQRES   3 A  333  ARG ASP ILE SER LEU ALA ARG ARG ARG LEU GLN ILE LEU
SEQRES   4 A  333  ARG GLU ALA LEU ALA SER LEU LEU PRO PRO LEU PRO SER
SEQRES   5 A  333  ASP VAL ALA VAL THR ASP GLU LEU ALA PRO ASN SER PHE
SEQRES   6 A  333  ASP GLY THR MET VAL ARG VAL ARG LEU TYR ARG PRO SER
SEQRES   7 A  333  GLU VAL THR GLY PRO LEU PRO VAL LEU LEU TRP ILE HIS
SEQRES   8 A  333  GLY GLY GLY TYR VAL MET GLY ALA PRO GLU MET ASN ASP
SEQRES   9 A  333  GLN GLN CYS ALA GLU LEU ALA GLN ARG ILE PRO ALA LEU
SEQRES  10 A  333  VAL ALA SER VAL ASP TYR ARG LEU ALA PRO GLU HIS PRO
SEQRES  11 A  333  TYR PRO ALA PRO LEU GLU ASP CYS TYR ALA ALA LEU ARG
SEQRES  12 A  333  TRP VAL ALA GLU ARG ALA GLU GLN LEU GLY VAL ASP ARG
SEQRES  13 A  333  GLU ARG LEU ALA ILE ALA GLY ALA SER ALA GLY GLY GLY
SEQRES  14 A  333  LEU ALA ALA GLY LEU ALA LEU LEU ALA ARG ASP ARG GLY
SEQRES  15 A  333  GLU VAL PRO VAL ARG PHE GLN LEU LEU ILE TYR PRO MET
SEQRES  16 A  333  LEU ASP ASP ARG ASN GLN THR PRO SER SER TYR GLU ILE
SEQRES  17 A  333  THR ASP PRO ARG LEU ILE TRP THR ARG ASP TRP ASN LEU
SEQRES  18 A  333  ILE GLY TRP ARG ALA TYR LEU GLY ARG GLU PRO GLY SER
SEQRES  19 A  333  PRO ASP VAL PRO PRO TYR ALA ALA PRO ALA ARG ALA ASP
SEQRES  20 A  333  ASP LEU ALA GLY LEU PRO PRO ALA TYR VAL LEU VAL GLY
SEQRES  21 A  333  THR ALA ASP LEU PHE ARG ASP GLU ASP ILE ALA TYR ALA
SEQRES  22 A  333  GLN ARG LEU MET GLN ALA GLY VAL PRO THR GLU LEU HIS
SEQRES  23 A  333  VAL PHE ALA GLY ALA PHE HIS GLY PHE ASP VAL PHE ALA
SEQRES  24 A  333  PRO THR ALA TRP VAL SER GLN ARG ALA ASN ALA GLU VAL
SEQRES  25 A  333  LEU ALA VAL LEU GLN ARG ALA LEU LYS LEU ALA ALA ALA
SEQRES  26 A  333  LEU GLU HIS HIS HIS HIS HIS HIS
SEQRES   1 B  333  MET SER VAL PHE ALA ARG LEU ASP PRO GLU LEU ALA ALA
SEQRES   2 B  333  ALA LEU ARG GLU ILE PRO GLU GLU PHE LEU LEU ASP LEU
SEQRES   3 B  333  ARG ASP ILE SER LEU ALA ARG ARG ARG LEU GLN ILE LEU
SEQRES   4 B  333  ARG GLU ALA LEU ALA SER LEU LEU PRO PRO LEU PRO SER
SEQRES   5 B  333  ASP VAL ALA VAL THR ASP GLU LEU ALA PRO ASN SER PHE
SEQRES   6 B  333  ASP GLY THR MET VAL ARG VAL ARG LEU TYR ARG PRO SER
SEQRES   7 B  333  GLU VAL THR GLY PRO LEU PRO VAL LEU LEU TRP ILE HIS
SEQRES   8 B  333  GLY GLY GLY TYR VAL MET GLY ALA PRO GLU MET ASN ASP
SEQRES   9 B  333  GLN GLN CYS ALA GLU LEU ALA GLN ARG ILE PRO ALA LEU
SEQRES  10 B  333  VAL ALA SER VAL ASP TYR ARG LEU ALA PRO GLU HIS PRO
SEQRES  11 B  333  TYR PRO ALA PRO LEU GLU ASP CYS TYR ALA ALA LEU ARG
SEQRES  12 B  333  TRP VAL ALA GLU ARG ALA GLU GLN LEU GLY VAL ASP ARG
SEQRES  13 B  333  GLU ARG LEU ALA ILE ALA GLY ALA SER ALA GLY GLY GLY
SEQRES  14 B  333  LEU ALA ALA GLY LEU ALA LEU LEU ALA ARG ASP ARG GLY
SEQRES  15 B  333  GLU VAL PRO VAL ARG PHE GLN LEU LEU ILE TYR PRO MET
SEQRES  16 B  333  LEU ASP ASP ARG ASN GLN THR PRO SER SER TYR GLU ILE
SEQRES  17 B  333  THR ASP PRO ARG LEU ILE TRP THR ARG ASP TRP ASN LEU
SEQRES  18 B  333  ILE GLY TRP ARG ALA TYR LEU GLY ARG GLU PRO GLY SER
SEQRES  19 B  333  PRO ASP VAL PRO PRO TYR ALA ALA PRO ALA ARG ALA ASP
SEQRES  20 B  333  ASP LEU ALA GLY LEU PRO PRO ALA TYR VAL LEU VAL GLY
SEQRES  21 B  333  THR ALA ASP LEU PHE ARG ASP GLU ASP ILE ALA TYR ALA
SEQRES  22 B  333  GLN ARG LEU MET GLN ALA GLY VAL PRO THR GLU LEU HIS
SEQRES  23 B  333  VAL PHE ALA GLY ALA PHE HIS GLY PHE ASP VAL PHE ALA
SEQRES  24 B  333  PRO THR ALA TRP VAL SER GLN ARG ALA ASN ALA GLU VAL
SEQRES  25 B  333  LEU ALA VAL LEU GLN ARG ALA LEU LYS LEU ALA ALA ALA
SEQRES  26 B  333  LEU GLU HIS HIS HIS HIS HIS HIS
HET    SIN  A 401       8
HET    GOL  A 402       6
HET    PEG  A 403       7
HET    PEG  A 404       7
HET    GOL  A 405       6
HET    GOL  A 406       6
HET    EDO  A 407       4
HET    GOL  A 408       6
HET    EDO  A 409       4
HET    EDO  A 410       4
HET    EDO  A 411       4
HET    SIN  B 401       8
HET    PEG  B 402       7
HET    EDO  B 403       4
HET    PEG  B 404       7
HET    EDO  B 405       4
HET    EDO  B 406       4
HET    EDO  B 407       4
HET    GOL  B 408       6
HET    EDO  B 409       4
HETNAM     SIN SUCCINIC ACID
HETNAM     GOL GLYCEROL
HETNAM     PEG DI(HYDROXYETHYL)ETHER
HETNAM     EDO 1,2-ETHANEDIOL
HETSYN     GOL GLYCERIN; PROPANE-1,2,3-TRIOL
HETSYN     EDO ETHYLENE GLYCOL
FORMUL   3  SIN    2(C4 H6 O4)
FORMUL   4  GOL    5(C3 H8 O3)
FORMUL   5  PEG    4(C4 H10 O3)
FORMUL   9  EDO    9(C2 H6 O2)
FORMUL  23  HOH   *417(H2 O)
HELIX    1 AA1 ASP A    8  GLU A   17  1                                  10
HELIX    2 AA2 ILE A   18  LEU A   23  5                                   6
HELIX    3 AA3 ASP A   28  LEU A   46  1                                  19
HELIX    4 AA4 ALA A   99  MET A  102  5                                   4
HELIX    5 AA5 ASN A  103  ILE A  114  1                                  12
HELIX    6 AA6 PRO A  132  GLY A  153  1                                  22
HELIX    7 AA7 SER A  165  GLY A  182  1                                  18
HELIX    8 AA8 PRO A  203  ILE A  208  1                                   6
HELIX    9 AA9 ASP A  210  ILE A  214  5                                   5
HELIX   10 AB1 THR A  216  GLY A  229  1                                  14
HELIX   11 AB2 ALA A  242  ALA A  246  5                                   5
HELIX   12 AB3 PHE A  265  ALA A  279  1                                  15
HELIX   13 AB4 GLY A  294  ALA A  299  1                                   6
HELIX   14 AB5 ALA A  302  LYS A  321  1                                  20
HELIX   15 AB6 ASP B    8  GLU B   17  1                                  10
HELIX   16 AB7 ILE B   18  LEU B   23  5                                   6
HELIX   17 AB8 ASP B   28  GLU B   41  1                                  14
HELIX   18 AB9 ALA B   99  MET B  102  5                                   4
HELIX   19 AC1 ASN B  103  ILE B  114  1                                  12
HELIX   20 AC2 PRO B  132  ARG B  148  1                                  17
HELIX   21 AC3 ARG B  148  GLY B  153  1                                   6
HELIX   22 AC4 SER B  165  GLY B  182  1                                  18
HELIX   23 AC5 THR B  202  ILE B  208  1                                   7
HELIX   24 AC6 ASP B  210  ILE B  214  5                                   5
HELIX   25 AC7 THR B  216  GLY B  229  1                                  14
HELIX   26 AC8 ALA B  242  ALA B  246  5                                   5
HELIX   27 AC9 PHE B  265  ALA B  279  1                                  15
HELIX   28 AD1 GLY B  294  ALA B  299  1                                   6
HELIX   29 AD2 ALA B  302  LYS B  321  1                                  20
SHEET    1 AA116 VAL A  54  PRO A  62  0
SHEET    2 AA116 MET A  69  PRO A  77 -1  O  VAL A  70   N  ALA A  61
SHEET    3 AA116 LEU A 117  VAL A 121 -1  O  SER A 120   N  ARG A  73
SHEET    4 AA116 LEU A  84  ILE A  90  1  N  LEU A  87   O  ALA A 119
SHEET    5 AA116 VAL A 154  ALA A 164  1  O  ALA A 160   N  LEU A  88
SHEET    6 AA116 PHE A 188  ILE A 192  1  O  ILE A 192   N  GLY A 163
SHEET    7 AA116 ALA A 255  ALA A 262  1  O  TYR A 256   N  LEU A 191
SHEET    8 AA116 THR A 283  PHE A 292  1  O  GLU A 284   N  VAL A 257
SHEET    9 AA116 THR B 283  PHE B 292 -1  O  LEU B 285   N  VAL A 287
SHEET   10 AA116 ALA B 255  ALA B 262  1  N  VAL B 257   O  HIS B 286
SHEET   11 AA116 PHE B 188  ILE B 192  1  N  LEU B 191   O  TYR B 256
SHEET   12 AA116 VAL B 154  ALA B 164  1  N  GLY B 163   O  ILE B 192
SHEET   13 AA116 LEU B  84  ILE B  90  1  N  LEU B  88   O  ALA B 160
SHEET   14 AA116 LEU B 117  VAL B 121  1  O  ALA B 119   N  LEU B  87
SHEET   15 AA116 MET B  69  PRO B  77 -1  N  ARG B  73   O  SER B 120
SHEET   16 AA116 VAL B  54  PRO B  62 -1  N  THR B  57   O  LEU B  74
CISPEP   1 ILE A  114    PRO A  115          0       -11.15
CISPEP   2 ALA A  126    PRO A  127          0        -2.31
CISPEP   3 TYR A  131    PRO A  132          0         2.71
CISPEP   4 ILE B  114    PRO B  115          0       -10.70
CISPEP   5 ALA B  126    PRO B  127          0        -1.38
CISPEP   6 TYR B  131    PRO B  132          0         2.30
CRYST1  129.402  129.402  122.792  90.00  90.00  90.00 P 43 21 2    16
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.007728  0.000000  0.000000        0.00000
SCALE2      0.000000  0.007728  0.000000        0.00000
SCALE3      0.000000  0.000000  0.008144        0.00000
TER    2511      ALA A 323
TER    4974      ALA B 323
MASTER      318    0   20   29   16    0    0    6 5475    2  110   52
END