longtext: 7x0c-pdb

content
HEADER    HYDROLASE                               21-FEB-22   7X0C
TITLE     CRYSTAL STRUCTURE OF PHOSPHOLIPASE A1, ATDSEL
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: PHOSPHOLIPASE A1-IIGAMMA;
COMPND   3 CHAIN: A, B;
COMPND   4 SYNONYM: DAD1-LIKE SEEDLING ESTABLISHMENT-RELATED LIPASE,ATDSEL,
COMPND   5 PHOSPHOLIPASE DSEL;
COMPND   6 EC: 3.1.1.-;
COMPND   7 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: ARABIDOPSIS THALIANA;
SOURCE   3 ORGANISM_COMMON: THALE CRESS;
SOURCE   4 ORGANISM_TAXID: 3702;
SOURCE   5 GENE: DSEL, AT4G18550, F28J12.210;
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562
KEYWDS    PHOSPHOLIPASE A1, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    Y.HEO,I.LEE,S.MOON,W.LEE
REVDAT   1   13-APR-22 7X0C    0
JRNL        AUTH   Y.HEO,I.LEE,S.MOON,J.YUN,E.KIM,S.PARK,J.PARK,W.KIM,W.LEE
JRNL        TITL   CRYSTAL STRUCTURES OF THE PLANT PHOSPHOLIPASE A1 PROTEINS
JRNL        TITL 2 REVEAL A UNIQUE DIMERIZATION DOMAIN
JRNL        REF    MOLECULES                                  2022
JRNL        REFN                   ESSN 1420-3049
JRNL        DOI    10.3390/MOLECULES27072317
REMARK   2
REMARK   2 RESOLUTION.    1.80 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX 1.10.1_2155
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : GEOSTD + MONOMER LIBRARY + CDL V1.2
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.80
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 33.29
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.354
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.7
REMARK   3   NUMBER OF REFLECTIONS             : 98085
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.180
REMARK   3   R VALUE            (WORKING SET) : 0.178
REMARK   3   FREE R VALUE                     : 0.212
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.995
REMARK   3   FREE R VALUE TEST SET COUNT      : 4899
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 33.2867 -  5.5817    0.98     3154   158  0.1755 0.1899
REMARK   3     2  5.5817 -  4.4337    0.99     3111   152  0.1642 0.2046
REMARK   3     3  4.4337 -  3.8742    0.98     3108   150  0.1609 0.2006
REMARK   3     4  3.8742 -  3.5204    0.99     3086   158  0.1852 0.1817
REMARK   3     5  3.5204 -  3.2683    1.00     3125   161  0.1828 0.2164
REMARK   3     6  3.2683 -  3.0758    1.00     3123   156  0.1910 0.2262
REMARK   3     7  3.0758 -  2.9218    1.00     3127   166  0.1860 0.2202
REMARK   3     8  2.9218 -  2.7947    1.00     3137   150  0.1881 0.2176
REMARK   3     9  2.7947 -  2.6872    1.00     3115   164  0.1750 0.1935
REMARK   3    10  2.6872 -  2.5945    1.00     3103   186  0.1798 0.1946
REMARK   3    11  2.5945 -  2.5134    1.00     3086   163  0.1788 0.2535
REMARK   3    12  2.5134 -  2.4416    1.00     3102   181  0.1820 0.2041
REMARK   3    13  2.4416 -  2.3773    1.00     3103   170  0.1786 0.2388
REMARK   3    14  2.3773 -  2.3193    1.00     3107   162  0.1760 0.2096
REMARK   3    15  2.3193 -  2.2666    1.00     3128   152  0.1718 0.2237
REMARK   3    16  2.2666 -  2.2184    1.00     3115   153  0.1777 0.2051
REMARK   3    17  2.2184 -  2.1740    1.00     3061   189  0.1766 0.2206
REMARK   3    18  2.1740 -  2.1330    1.00     3134   179  0.1775 0.2288
REMARK   3    19  2.1330 -  2.0949    1.00     3083   194  0.1787 0.2181
REMARK   3    20  2.0949 -  2.0594    1.00     3093   145  0.1833 0.2125
REMARK   3    21  2.0594 -  2.0262    1.00     3120   152  0.1832 0.2414
REMARK   3    22  2.0262 -  1.9950    1.00     3094   178  0.1801 0.2156
REMARK   3    23  1.9950 -  1.9657    1.00     3144   141  0.1786 0.2224
REMARK   3    24  1.9657 -  1.9380    1.00     3094   160  0.1775 0.2405
REMARK   3    25  1.9380 -  1.9118    1.00     3102   164  0.1780 0.1995
REMARK   3    26  1.9118 -  1.8870    1.00     3100   159  0.1788 0.2211
REMARK   3    27  1.8870 -  1.8634    1.00     3114   171  0.1877 0.2464
REMARK   3    28  1.8634 -  1.8409    1.00     3078   167  0.1923 0.2407
REMARK   3    29  1.8409 -  1.8195    1.00     3130   167  0.1902 0.2153
REMARK   3    30  1.8195 -  1.7991    0.99     3009   151  0.2014 0.2277
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL
REMARK   3   SOLVENT RADIUS     : 1.11
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.167
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 19.684
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 22.08
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 24.94
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :  0.012           6563
REMARK   3   ANGLE     :  1.127           8881
REMARK   3   CHIRALITY :  0.076            937
REMARK   3   PLANARITY :  0.008           1159
REMARK   3   DIHEDRAL  : 14.258           3881
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 7X0C COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 25-FEB-22.
REMARK 100 THE DEPOSITION ID IS D_1300027808.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 25-JUN-12
REMARK 200  TEMPERATURE           (KELVIN) : 93
REMARK 200  PH                             : NULL
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : PHOTON FACTORY
REMARK 200  BEAMLINE                       : BL-17A
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.0082
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : PIXEL
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS EIGER X 16M
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : NULL
REMARK 200  DATA SCALING SOFTWARE          : NULL
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 105892
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.799
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.8
REMARK 200  DATA REDUNDANCY                : 7.500
REMARK 200  R MERGE                    (I) : 0.08600
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 35.2900
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.80
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.86
REMARK 200  COMPLETENESS FOR SHELL     (%) : NULL
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL
REMARK 200  R MERGE FOR SHELL          (I) : 0.40000
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 4.700
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: NULL
REMARK 200 STARTING MODEL: 2YIJ
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 58.58
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.97
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.02M CALCIUM CHLORIDE, 0.1M SODIUM
REMARK 280  ACETATE, 30% MPD, VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 293K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000       47.67150
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 2800 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 32510 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -20.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     GLY A     0
REMARK 465     MET A     1
REMARK 465     LYS A     2
REMARK 465     ARG A     3
REMARK 465     LYS A     4
REMARK 465     LYS A     5
REMARK 465     LYS A     6
REMARK 465     GLU A     7
REMARK 465     GLU A     8
REMARK 465     GLU A     9
REMARK 465     GLU A    10
REMARK 465     GLU A    11
REMARK 465     LYS A    12
REMARK 465     LEU A    13
REMARK 465     ARG A   120
REMARK 465     GLU A   121
REMARK 465     PRO A   159
REMARK 465     LEU A   160
REMARK 465     GLY B     0
REMARK 465     MET B     1
REMARK 465     LYS B     2
REMARK 465     ARG B     3
REMARK 465     LYS B     4
REMARK 465     LYS B     5
REMARK 465     LYS B     6
REMARK 465     GLU B     7
REMARK 465     GLU B     8
REMARK 465     GLU B     9
REMARK 465     GLU B    10
REMARK 465     GLU B    11
REMARK 465     LYS B    12
REMARK 465     LEU B    13
REMARK 465     ILE B    14
REMARK 465     VAL B    15
REMARK 465     THR B    16
REMARK 465     ARG B   120
REMARK 465     GLU B   121
REMARK 465     PRO B   159
REMARK 465     LEU B   160
REMARK 465     GLU B   161
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   NH2  ARG A    24     OE2  GLU A   227              2.03
REMARK 500   O    SER B   119     NZ   LYS B   125              2.19
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    ARG A 154   NE  -  CZ  -  NH1 ANGL. DEV. =  -3.9 DEGREES
REMARK 500    ARG A 154   NE  -  CZ  -  NH2 ANGL. DEV. =   3.0 DEGREES
REMARK 500    ASP B 413   CB  -  CG  -  OD1 ANGL. DEV. =   7.2 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    GLU A  87      -56.92   -120.67
REMARK 500    THR A  93       56.03    -92.60
REMARK 500    GLU A 126       -6.19   -140.65
REMARK 500    SER A 236     -122.50     63.54
REMARK 500    VAL A 407       75.44   -114.74
REMARK 500    GLU B  87      -57.15   -120.30
REMARK 500    THR B  93       55.84    -90.50
REMARK 500    GLU B 126       -2.68   -140.45
REMARK 500    GLU B 167       85.76    -66.64
REMARK 500    SER B 236     -121.69     62.26
REMARK 500    VAL B 407       73.81   -113.05
REMARK 500
REMARK 500 REMARK: NULL
DBREF  7X0C A    1   419  UNP    O49523   DSEL_ARATH       1    419
DBREF  7X0C B    1   419  UNP    O49523   DSEL_ARATH       1    419
SEQADV 7X0C GLY A    0  UNP  O49523              EXPRESSION TAG
SEQADV 7X0C GLY B    0  UNP  O49523              EXPRESSION TAG
SEQRES   1 A  420  GLY MET LYS ARG LYS LYS LYS GLU GLU GLU GLU GLU LYS
SEQRES   2 A  420  LEU ILE VAL THR ARG GLU PHE ALA LYS ARG TRP ARG ASP
SEQRES   3 A  420  LEU SER GLY GLN ASN HIS TRP LYS GLY MET LEU GLN PRO
SEQRES   4 A  420  LEU ASP GLN ASP LEU ARG GLU TYR ILE ILE HIS TYR GLY
SEQRES   5 A  420  GLU MET ALA GLN ALA GLY TYR ASP THR PHE ASN ILE ASN
SEQRES   6 A  420  THR GLU SER GLN PHE ALA GLY ALA SER ILE TYR SER ARG
SEQRES   7 A  420  LYS ASP PHE PHE ALA LYS VAL GLY LEU GLU ILE ALA HIS
SEQRES   8 A  420  PRO TYR THR LYS TYR LYS VAL THR LYS PHE ILE TYR ALA
SEQRES   9 A  420  THR SER ASP ILE HIS VAL PRO GLU SER PHE LEU LEU PHE
SEQRES  10 A  420  PRO ILE SER ARG GLU GLY TRP SER LYS GLU SER ASN TRP
SEQRES  11 A  420  MET GLY TYR VAL ALA VAL THR ASP ASP GLN GLY THR ALA
SEQRES  12 A  420  LEU LEU GLY ARG ARG ASP ILE VAL VAL SER TRP ARG GLY
SEQRES  13 A  420  SER VAL GLN PRO LEU GLU TRP VAL GLU ASP PHE GLU PHE
SEQRES  14 A  420  GLY LEU VAL ASN ALA ILE LYS ILE PHE GLY GLU ARG ASN
SEQRES  15 A  420  ASP GLN VAL GLN ILE HIS GLN GLY TRP TYR SER ILE TYR
SEQRES  16 A  420  MET SER GLN ASP GLU ARG SER PRO PHE THR LYS THR ASN
SEQRES  17 A  420  ALA ARG ASP GLN VAL LEU ARG GLU VAL GLY ARG LEU LEU
SEQRES  18 A  420  GLU LYS TYR LYS ASP GLU GLU VAL SER ILE THR ILE CYS
SEQRES  19 A  420  GLY HIS SER LEU GLY ALA ALA LEU ALA THR LEU SER ALA
SEQRES  20 A  420  THR ASP ILE VAL ALA ASN GLY TYR ASN ARG PRO LYS SER
SEQRES  21 A  420  ARG PRO ASP LYS SER CYS PRO VAL THR ALA PHE VAL PHE
SEQRES  22 A  420  ALA SER PRO ARG VAL GLY ASP SER ASP PHE ARG LYS LEU
SEQRES  23 A  420  PHE SER GLY LEU GLU ASP ILE ARG VAL LEU ARG THR ARG
SEQRES  24 A  420  ASN LEU PRO ASP VAL ILE PRO ILE TYR PRO PRO ILE GLY
SEQRES  25 A  420  TYR SER GLU VAL GLY ASP GLU PHE PRO ILE ASP THR ARG
SEQRES  26 A  420  LYS SER PRO TYR MET LYS SER PRO GLY ASN LEU ALA THR
SEQRES  27 A  420  PHE HIS CYS LEU GLU GLY TYR LEU HIS GLY VAL ALA GLY
SEQRES  28 A  420  THR GLN GLY THR ASN LYS ALA ASP LEU PHE ARG LEU ASP
SEQRES  29 A  420  VAL GLU ARG ALA ILE GLY LEU VAL ASN LYS SER VAL ASP
SEQRES  30 A  420  GLY LEU LYS ASP GLU CYS MET VAL PRO GLY LYS TRP ARG
SEQRES  31 A  420  VAL LEU LYS ASN LYS GLY MET ALA GLN GLN ASP ASP GLY
SEQRES  32 A  420  SER TRP GLU LEU VAL ASP HIS GLU ILE ASP ASP ASN GLU
SEQRES  33 A  420  ASP LEU ASP PHE
SEQRES   1 B  420  GLY MET LYS ARG LYS LYS LYS GLU GLU GLU GLU GLU LYS
SEQRES   2 B  420  LEU ILE VAL THR ARG GLU PHE ALA LYS ARG TRP ARG ASP
SEQRES   3 B  420  LEU SER GLY GLN ASN HIS TRP LYS GLY MET LEU GLN PRO
SEQRES   4 B  420  LEU ASP GLN ASP LEU ARG GLU TYR ILE ILE HIS TYR GLY
SEQRES   5 B  420  GLU MET ALA GLN ALA GLY TYR ASP THR PHE ASN ILE ASN
SEQRES   6 B  420  THR GLU SER GLN PHE ALA GLY ALA SER ILE TYR SER ARG
SEQRES   7 B  420  LYS ASP PHE PHE ALA LYS VAL GLY LEU GLU ILE ALA HIS
SEQRES   8 B  420  PRO TYR THR LYS TYR LYS VAL THR LYS PHE ILE TYR ALA
SEQRES   9 B  420  THR SER ASP ILE HIS VAL PRO GLU SER PHE LEU LEU PHE
SEQRES  10 B  420  PRO ILE SER ARG GLU GLY TRP SER LYS GLU SER ASN TRP
SEQRES  11 B  420  MET GLY TYR VAL ALA VAL THR ASP ASP GLN GLY THR ALA
SEQRES  12 B  420  LEU LEU GLY ARG ARG ASP ILE VAL VAL SER TRP ARG GLY
SEQRES  13 B  420  SER VAL GLN PRO LEU GLU TRP VAL GLU ASP PHE GLU PHE
SEQRES  14 B  420  GLY LEU VAL ASN ALA ILE LYS ILE PHE GLY GLU ARG ASN
SEQRES  15 B  420  ASP GLN VAL GLN ILE HIS GLN GLY TRP TYR SER ILE TYR
SEQRES  16 B  420  MET SER GLN ASP GLU ARG SER PRO PHE THR LYS THR ASN
SEQRES  17 B  420  ALA ARG ASP GLN VAL LEU ARG GLU VAL GLY ARG LEU LEU
SEQRES  18 B  420  GLU LYS TYR LYS ASP GLU GLU VAL SER ILE THR ILE CYS
SEQRES  19 B  420  GLY HIS SER LEU GLY ALA ALA LEU ALA THR LEU SER ALA
SEQRES  20 B  420  THR ASP ILE VAL ALA ASN GLY TYR ASN ARG PRO LYS SER
SEQRES  21 B  420  ARG PRO ASP LYS SER CYS PRO VAL THR ALA PHE VAL PHE
SEQRES  22 B  420  ALA SER PRO ARG VAL GLY ASP SER ASP PHE ARG LYS LEU
SEQRES  23 B  420  PHE SER GLY LEU GLU ASP ILE ARG VAL LEU ARG THR ARG
SEQRES  24 B  420  ASN LEU PRO ASP VAL ILE PRO ILE TYR PRO PRO ILE GLY
SEQRES  25 B  420  TYR SER GLU VAL GLY ASP GLU PHE PRO ILE ASP THR ARG
SEQRES  26 B  420  LYS SER PRO TYR MET LYS SER PRO GLY ASN LEU ALA THR
SEQRES  27 B  420  PHE HIS CYS LEU GLU GLY TYR LEU HIS GLY VAL ALA GLY
SEQRES  28 B  420  THR GLN GLY THR ASN LYS ALA ASP LEU PHE ARG LEU ASP
SEQRES  29 B  420  VAL GLU ARG ALA ILE GLY LEU VAL ASN LYS SER VAL ASP
SEQRES  30 B  420  GLY LEU LYS ASP GLU CYS MET VAL PRO GLY LYS TRP ARG
SEQRES  31 B  420  VAL LEU LYS ASN LYS GLY MET ALA GLN GLN ASP ASP GLY
SEQRES  32 B  420  SER TRP GLU LEU VAL ASP HIS GLU ILE ASP ASP ASN GLU
SEQRES  33 B  420  ASP LEU ASP PHE
FORMUL   3  HOH   *423(H2 O)
HELIX    1 AA1 ARG A   17  SER A   27  1                                  11
HELIX    2 AA2 ASP A   40  PHE A   61  1                                  22
HELIX    3 AA3 ASP A   79  VAL A   84  1                                   6
HELIX    4 AA4 ASP A  137  GLY A  145  1                                   9
HELIX    5 AA5 TRP A  162  GLU A  167  5                                   6
HELIX    6 AA6 ALA A  173  GLY A  178  1                                   6
HELIX    7 AA7 GLU A  179  ASP A  182  5                                   4
HELIX    8 AA8 GLN A  188  SER A  196  1                                   9
HELIX    9 AA9 ASN A  207  TYR A  223  1                                  17
HELIX   10 AB1 SER A  236  ASN A  252  1                                  17
HELIX   11 AB2 ASP A  279  GLY A  288  1                                  10
HELIX   12 AB3 VAL A  303  TYR A  307  5                                   5
HELIX   13 AB4 ASP A  322  SER A  326  5                                   5
HELIX   14 AB5 ASN A  334  CYS A  340  1                                   7
HELIX   15 AB6 CYS A  340  THR A  351  1                                  12
HELIX   16 AB7 ALA A  367  SER A  374  5                                   8
HELIX   17 AB8 LYS A  379  MET A  383  5                                   5
HELIX   18 AB9 LEU A  391  LYS A  394  5                                   4
HELIX   19 AC1 GLU B   18  SER B   27  1                                  10
HELIX   20 AC2 ASP B   40  PHE B   61  1                                  22
HELIX   21 AC3 ASP B   79  VAL B   84  1                                   6
HELIX   22 AC4 ASP B  137  GLY B  145  1                                   9
HELIX   23 AC5 TRP B  162  GLU B  167  5                                   6
HELIX   24 AC6 ALA B  173  GLY B  178  1                                   6
HELIX   25 AC7 GLU B  179  ASP B  182  5                                   4
HELIX   26 AC8 GLN B  188  SER B  196  1                                   9
HELIX   27 AC9 ASN B  207  TYR B  223  1                                  17
HELIX   28 AD1 SER B  236  ASN B  252  1                                  17
HELIX   29 AD2 ASP B  279  GLY B  288  1                                  10
HELIX   30 AD3 VAL B  303  TYR B  307  5                                   5
HELIX   31 AD4 ASP B  322  SER B  326  5                                   5
HELIX   32 AD5 ASN B  334  CYS B  340  1                                   7
HELIX   33 AD6 CYS B  340  THR B  351  1                                  12
HELIX   34 AD7 ALA B  367  SER B  374  5                                   8
HELIX   35 AD8 LYS B  379  MET B  383  5                                   5
HELIX   36 AD9 LEU B  391  LYS B  394  5                                   4
SHEET    1 AA1 7 TYR A  95  ALA A 103  0
SHEET    2 AA1 7 ASN A 128  THR A 136 -1  O  MET A 130   N  ILE A 101
SHEET    3 AA1 7 ARG A 147  TRP A 153 -1  O  SER A 152   N  TYR A 132
SHEET    4 AA1 7 VAL A 228  HIS A 235  1  O  SER A 229   N  ILE A 149
SHEET    5 AA1 7 VAL A 267  PHE A 272  1  O  THR A 268   N  ILE A 230
SHEET    6 AA1 7 ILE A 292  ASN A 299  1  O  THR A 297   N  VAL A 271
SHEET    7 AA1 7 ASP A 317  ILE A 321  1  O  ASP A 317   N  ARG A 296
SHEET    1 AA2 2 LEU A 170  ASN A 172  0
SHEET    2 AA2 2 GLN A 185  HIS A 187 -1  O  ILE A 186   N  VAL A 171
SHEET    1 AA3 2 MET A 396  GLN A 398  0
SHEET    2 AA3 2 TRP A 404  LEU A 406 -1  O  GLU A 405   N  ALA A 397
SHEET    1 AA4 7 TYR B  95  ALA B 103  0
SHEET    2 AA4 7 ASN B 128  THR B 136 -1  O  MET B 130   N  ILE B 101
SHEET    3 AA4 7 ARG B 147  TRP B 153 -1  O  SER B 152   N  TYR B 132
SHEET    4 AA4 7 VAL B 228  HIS B 235  1  O  THR B 231   N  ILE B 149
SHEET    5 AA4 7 VAL B 267  PHE B 272  1  O  THR B 268   N  ILE B 230
SHEET    6 AA4 7 ILE B 292  ASN B 299  1  O  THR B 297   N  VAL B 271
SHEET    7 AA4 7 ASP B 317  ILE B 321  1  O  ASP B 317   N  ARG B 296
SHEET    1 AA5 2 LEU B 170  ASN B 172  0
SHEET    2 AA5 2 GLN B 185  HIS B 187 -1  O  ILE B 186   N  VAL B 171
SHEET    1 AA6 2 MET B 396  GLN B 398  0
SHEET    2 AA6 2 TRP B 404  LEU B 406 -1  O  GLU B 405   N  ALA B 397
CISPEP   1 GLN A   37    PRO A   38          0        -2.31
CISPEP   2 TYR A  307    PRO A  308          0        -6.40
CISPEP   3 SER A  331    PRO A  332          0        -5.18
CISPEP   4 GLN B   37    PRO B   38          0        -2.06
CISPEP   5 TYR B  307    PRO B  308          0        -3.68
CISPEP   6 SER B  331    PRO B  332          0        -1.19
CRYST1   73.977   95.343   79.278  90.00 105.14  90.00 P 1 21 1      4
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.013518  0.000000  0.003658        0.00000
SCALE2      0.000000  0.010488  0.000000        0.00000
SCALE3      0.000000  0.000000  0.013068        0.00000
TER    3221      PHE A 419
TER    6411      PHE B 419
MASTER      320    0    0   36   22    0    0    6 6832    2    0   66
END