longtext: 7xnm-pdb

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HEADER    HYDROLASE                               29-APR-22   7XNM
TITLE     STRUCTURE OF PORCINE DIPEPTIDYL PEPTIDASE 4 INHIBITORY PEPTIDE COMPLEX
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: DIPEPTIDYL PEPTIDASE 4 SOLUBLE FORM;
COMPND   3 CHAIN: A, B;
COMPND   4 SYNONYM: DIPEPTIDYL PEPTIDASE IV SOLUBLE FORM;
COMPND   5 EC: 3.4.14.5;
COMPND   6 MOL_ID: 2;
COMPND   7 MOLECULE: ILE-LEU-ALA-PRO-PRO-GLU-ARG;
COMPND   8 CHAIN: C, D;
COMPND   9 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: SUS SCROFA;
SOURCE   3 ORGANISM_COMMON: PIG;
SOURCE   4 ORGANISM_TAXID: 9823;
SOURCE   5 MOL_ID: 2;
SOURCE   6 SYNTHETIC: YES;
SOURCE   7 ORGANISM_SCIENTIFIC: CRASSOSTREA GIGAS;
SOURCE   8 ORGANISM_TAXID: 29159
KEYWDS    A SERINE PROTEASE SUBFAMILY, DIABETES MELLITUS TYPE 2, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    W.Y.LI,M.J.CAO
REVDAT   1   17-MAY-23 7XNM    0
JRNL        AUTH   W.Y.LI,M.J.CAO
JRNL        TITL   STRUCTURE OF PORCINE DIPEPTIDYL PEPTIDASE 4 INHIBITORY
JRNL        TITL 2 PEPTIDE COMPLEX
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   2
REMARK   2 RESOLUTION.    3.58 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX 1.19.2_4158
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : GEOSTD + MONOMER LIBRARY + CDL V1.2
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 3.58
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 29.48
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.360
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.0
REMARK   3   NUMBER OF REFLECTIONS             : 26023
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.229
REMARK   3   R VALUE            (WORKING SET) : 0.223
REMARK   3   FREE R VALUE                     : 0.299
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 7.680
REMARK   3   FREE R VALUE TEST SET COUNT      : 1999
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 29.4800 -  8.5500    0.99     1806   150  0.2139 0.2828
REMARK   3     2  8.5500 -  6.8200    1.00     1747   146  0.2221 0.3194
REMARK   3     3  6.8100 -  5.9600    1.00     1758   146  0.2331 0.2920
REMARK   3     4  5.9600 -  5.4200    1.00     1735   145  0.2243 0.2828
REMARK   3     5  5.4200 -  5.0300    1.00     1734   144  0.1995 0.2899
REMARK   3     6  5.0300 -  4.7400    1.00     1722   143  0.1999 0.2914
REMARK   3     7  4.7400 -  4.5000    1.00     1718   143  0.1865 0.2537
REMARK   3     8  4.5000 -  4.3100    1.00     1746   144  0.2009 0.3033
REMARK   3     9  4.3100 -  4.1400    1.00     1729   145  0.2167 0.2823
REMARK   3    10  4.1400 -  4.0000    1.00     1685   140  0.2279 0.3061
REMARK   3    11  4.0000 -  3.8700    0.99     1713   142  0.2539 0.3405
REMARK   3    12  3.8700 -  3.7600    0.99     1728   144  0.2599 0.3156
REMARK   3    13  3.7600 -  3.6600    0.98     1679   141  0.2786 0.3473
REMARK   3    14  3.6600 -  3.5800    0.90     1524   126  0.2702 0.3429
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL
REMARK   3   SOLVENT RADIUS     : 1.11
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.464
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 31.616
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 63.18
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 77.02
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :  0.004          12577
REMARK   3   ANGLE     :  0.676          17117
REMARK   3   CHIRALITY :  0.058           1858
REMARK   3   PLANARITY :  0.005           2162
REMARK   3   DIHEDRAL  : 10.001           1757
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : 1
REMARK   3   TLS GROUP : 1
REMARK   3    SELECTION: ALL
REMARK   3    ORIGIN FOR THE GROUP (A): -35.6352  37.8055  -8.1625
REMARK   3    T TENSOR
REMARK   3      T11:   0.4407 T22:   0.5075
REMARK   3      T33:   0.5167 T12:  -0.0042
REMARK   3      T13:  -0.0525 T23:   0.0289
REMARK   3    L TENSOR
REMARK   3      L11:   1.1437 L22:   0.2707
REMARK   3      L33:   0.8906 L12:  -0.0964
REMARK   3      L13:  -0.1430 L23:  -0.0210
REMARK   3    S TENSOR
REMARK   3      S11:   0.0220 S12:   0.2882 S13:  -0.0408
REMARK   3      S21:  -0.0365 S22:  -0.0402 S23:   0.0104
REMARK   3      S31:  -0.0354 S32:  -0.1866 S33:   0.0133
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 7XNM COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 12-MAY-22.
REMARK 100 THE DEPOSITION ID IS D_1300029180.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 07-FEB-21
REMARK 200  TEMPERATURE           (KELVIN) : 190
REMARK 200  PH                             : NULL
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : SSRF
REMARK 200  BEAMLINE                       : BL19U1
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.97894
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : SILICON CRYSTAL (111)
REMARK 200                                   MONOCHROMATOR
REMARK 200
REMARK 200  DETECTOR TYPE                  : PIXEL
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS EIGER X 16M
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000
REMARK 200  DATA SCALING SOFTWARE          : HKL-2000
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 26023
REMARK 200  RESOLUTION RANGE HIGH      (A) : 3.575
REMARK 200  RESOLUTION RANGE LOW       (A) : 29.480
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.0
REMARK 200  DATA REDUNDANCY                : 6.500
REMARK 200  R MERGE                    (I) : NULL
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 2.0000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 3.58
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 3.60
REMARK 200  COMPLETENESS FOR SHELL     (%) : NULL
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL
REMARK 200  R MERGE FOR SHELL          (I) : NULL
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHENIX
REMARK 200 STARTING MODEL: 1WCY
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 62.34
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 3.27
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 20% PEG 3350, 0.2 M AMMONIUM CHLORIDE,
REMARK 280  VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 298.15K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: C 1 2 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,Y,-Z
REMARK 290       3555   X+1/2,Y+1/2,Z
REMARK 290       4555   -X+1/2,Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   3  1.000000  0.000000  0.000000      128.67000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       37.80850
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   4 -1.000000  0.000000  0.000000      128.67000
REMARK 290   SMTRY2   4  0.000000  1.000000  0.000000       37.80850
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TETRAMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 11070 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 58340 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: 34.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I, J,
REMARK 350                    AND CHAINS: K
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     PRO A   766
REMARK 465     SER B    39
REMARK 465     ARG B    40
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     ILE A 194    CG1  CG2  CD1
REMARK 470     THR A 231    OG1  CG2
REMARK 470     GLU A 378    CG   CD   OE1  OE2
REMARK 470     LYS A 489    CG   CD   CE   NZ
REMARK 470     LYS A 523    CG   CD   CE   NZ
REMARK 470     TYR B  70    CG   CD1  CD2  CE1  CE2  CZ   OH
REMARK 470     LEU B 436    CG   CD1  CD2
REMARK 470     LYS B 441    CG   CD   CE   NZ
REMARK 470     LEU B 494    CG   CD1  CD2
REMARK 470     LYS B 648    CG   CD   CE   NZ
REMARK 470     LEU B 759    CG   CD1  CD2
REMARK 470     ILE C   1    CG1  CG2  CD1
REMARK 470     ARG C   7    CG   CD   NE   CZ   NH1  NH2
REMARK 475
REMARK 475 ZERO OCCUPANCY RESIDUES
REMARK 475 THE FOLLOWING RESIDUES WERE MODELED WITH ZERO OCCUPANCY.
REMARK 475 THE LOCATION AND PROPERTIES OF THESE RESIDUES MAY NOT
REMARK 475 BE RELIABLE. (M=MODEL NUMBER; RES=RESIDUE NAME;
REMARK 475 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE)
REMARK 475   M RES C  SSEQI
REMARK 475     GLU A    97
REMARK 475     LEU A    98
REMARK 475     GLY A    99
REMARK 475     TYR A   100
REMARK 475     GLU B    97
REMARK 475     LEU B    98
REMARK 475     GLY B    99
REMARK 475     TYR B   100
REMARK 480
REMARK 480 ZERO OCCUPANCY ATOM
REMARK 480 THE FOLLOWING RESIDUES HAVE ATOMS MODELED WITH ZERO
REMARK 480 OCCUPANCY. THE LOCATION AND PROPERTIES OF THESE ATOMS
REMARK 480 MAY NOT BE RELIABLE. (M=MODEL NUMBER; RES=RESIDUE NAME;
REMARK 480 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):
REMARK 480   M RES C SSEQI ATOMS
REMARK 480     SER A   39   CB   OG
REMARK 480     ARG A   40   CB   CG   CD   NE   CZ   NH1  NH2
REMARK 480     GLU A  145   CB   CG   CD   OE1  OE2
REMARK 480     ARG A  147   CG   CD   NE   CZ   NH1  NH2
REMARK 480     LYS A  391   NZ
REMARK 480     LYS A  399   CD   CE   NZ
REMARK 480     LYS A  464   CG   CD   CE   NZ
REMARK 480     SER A  484   CB   OG
REMARK 480     LYS A  513   CG   CD   CE   NZ
REMARK 480     LYS A  539   CD   CE   NZ
REMARK 480     LYS A  622   CD   CE   NZ
REMARK 480     GLU B  145   CB   CG   CD   OE1  OE2
REMARK 480     ARG B  147   CG   CD   NE   CZ   NH1  NH2
REMARK 480     LYS B  391   NZ
REMARK 480     LYS B  399   CD   CE   NZ
REMARK 480     LYS B  464   CG   CD   CE   NZ
REMARK 480     SER B  484   CB   OG
REMARK 480     LYS B  489   CD   CE   NZ
REMARK 480     LYS B  513   CG   CD   CE   NZ
REMARK 480     LYS B  523   CG   CD   CE   NZ
REMARK 480     LYS B  539   CD   CE   NZ
REMARK 480     LYS B  622   CD   CE   NZ
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    PHE A  57     -162.42   -121.13
REMARK 500    TYR A  58       94.76   -161.83
REMARK 500    SER A  64     -151.15   -147.22
REMARK 500    HIS A  66        6.73   -153.68
REMARK 500    ASN A  74      -17.06     92.63
REMARK 500    PHE A  89      -66.81    -93.32
REMARK 500    SER A  93       -8.38     65.53
REMARK 500    GLU A  97       26.52     43.02
REMARK 500    SER A 101     -166.61   -162.37
REMARK 500    GLN A 123      -97.86    -92.67
REMARK 500    TRP A 124     -121.26   -100.83
REMARK 500    TYR A 128      144.01   -174.34
REMARK 500    GLU A 146       77.82     55.15
REMARK 500    ASN A 151       48.94     72.00
REMARK 500    HIS A 162       39.07   -146.50
REMARK 500    ILE A 185      -64.36   -103.17
REMARK 500    VAL A 193      -73.11   -129.08
REMARK 500    VAL A 198     -166.12   -127.94
REMARK 500    ASP A 230       33.20    -83.23
REMARK 500    SER A 242     -135.81     63.86
REMARK 500    PRO A 255       85.35    -62.14
REMARK 500    LYS A 258     -178.52    -68.54
REMARK 500    ASN A 279       50.85   -106.18
REMARK 500    PRO A 290      170.91    -59.05
REMARK 500    VAL A 306      -70.63    -96.89
REMARK 500    ARG A 343       34.67    -85.64
REMARK 500    ARG A 356      -67.88    -95.94
REMARK 500    ASN A 377     -147.78    -91.26
REMARK 500    SER A 392      -75.34    -67.99
REMARK 500    ASN A 420       35.49    -97.49
REMARK 500    LYS A 423       -3.92     63.43
REMARK 500    GLU A 448       47.66    -94.26
REMARK 500    PRO A 451       10.03    -66.04
REMARK 500    LEU A 491      -88.79     46.45
REMARK 500    ASP A 515     -146.02   -141.38
REMARK 500    THR A 557       41.70    -89.33
REMARK 500    LEU A 561       93.90    -66.03
REMARK 500    HIS A 592       41.81    -78.10
REMARK 500    ARG A 597       54.18   -162.55
REMARK 500    THR A 600      -74.78   -113.74
REMARK 500    SER A 630     -117.31     60.84
REMARK 500    LYS A 648      -38.45   -131.75
REMARK 500    ASP A 678      -82.72   -112.63
REMARK 500    ASN A 679       47.21   -155.43
REMARK 500    ALA A 707       53.01   -118.58
REMARK 500    ASN A 710      -79.59    -92.17
REMARK 500    MET A 733      103.82   -168.65
REMARK 500    ASP A 739     -158.50    -80.82
REMARK 500    GLN B  61       91.27   -163.51
REMARK 500    SER B  64     -158.45   -104.63
REMARK 500
REMARK 500 THIS ENTRY HAS     105 RAMACHANDRAN OUTLIERS.
REMARK 500
REMARK 500 REMARK: NULL
DBREF  7XNM A   39   766  UNP    P22411   DPP4_PIG        39    766
DBREF  7XNM B   39   766  UNP    P22411   DPP4_PIG        39    766
DBREF  7XNM C    1     7  PDB    7XNM     7XNM             1      7
DBREF  7XNM D    1     7  PDB    7XNM     7XNM             1      7
SEQRES   1 A  728  SER ARG ARG THR TYR THR LEU THR ASP TYR LEU LYS SER
SEQRES   2 A  728  THR PHE ARG VAL LYS PHE TYR THR LEU GLN TRP ILE SER
SEQRES   3 A  728  ASP HIS GLU TYR LEU TYR LYS GLN GLU ASN ASN ILE LEU
SEQRES   4 A  728  LEU PHE ASN ALA GLU TYR GLY ASN SER SER ILE PHE LEU
SEQRES   5 A  728  GLU ASN SER THR PHE ASP GLU LEU GLY TYR SER THR ASN
SEQRES   6 A  728  ASP TYR SER VAL SER PRO ASP ARG GLN PHE ILE LEU PHE
SEQRES   7 A  728  GLU TYR ASN TYR VAL LYS GLN TRP ARG HIS SER TYR THR
SEQRES   8 A  728  ALA SER TYR ASP ILE TYR ASP LEU ASN LYS ARG GLN LEU
SEQRES   9 A  728  ILE THR GLU GLU ARG ILE PRO ASN ASN THR GLN TRP ILE
SEQRES  10 A  728  THR TRP SER PRO VAL GLY HIS LYS LEU ALA TYR VAL TRP
SEQRES  11 A  728  ASN ASN ASP ILE TYR VAL LYS ASN GLU PRO ASN LEU SER
SEQRES  12 A  728  SER GLN ARG ILE THR TRP THR GLY LYS GLU ASN VAL ILE
SEQRES  13 A  728  TYR ASN GLY VAL THR ASP TRP VAL TYR GLU GLU GLU VAL
SEQRES  14 A  728  PHE SER ALA TYR SER ALA LEU TRP TRP SER PRO ASN GLY
SEQRES  15 A  728  THR PHE LEU ALA TYR ALA GLN PHE ASN ASP THR GLU VAL
SEQRES  16 A  728  PRO LEU ILE GLU TYR SER PHE TYR SER ASP GLU SER LEU
SEQRES  17 A  728  GLN TYR PRO LYS THR VAL ARG ILE PRO TYR PRO LYS ALA
SEQRES  18 A  728  GLY ALA GLU ASN PRO THR VAL LYS PHE PHE VAL VAL ASP
SEQRES  19 A  728  THR ARG THR LEU SER PRO ASN ALA SER VAL THR SER TYR
SEQRES  20 A  728  GLN ILE VAL PRO PRO ALA SER VAL LEU ILE GLY ASP HIS
SEQRES  21 A  728  TYR LEU CYS GLY VAL THR TRP VAL THR GLU GLU ARG ILE
SEQRES  22 A  728  SER LEU GLN TRP ILE ARG ARG ALA GLN ASN TYR SER ILE
SEQRES  23 A  728  ILE ASP ILE CYS ASP TYR ASP GLU SER THR GLY ARG TRP
SEQRES  24 A  728  ILE SER SER VAL ALA ARG GLN HIS ILE GLU ILE SER THR
SEQRES  25 A  728  THR GLY TRP VAL GLY ARG PHE ARG PRO ALA GLU PRO HIS
SEQRES  26 A  728  PHE THR SER ASP GLY ASN SER PHE TYR LYS ILE ILE SER
SEQRES  27 A  728  ASN GLU GLU GLY TYR LYS HIS ILE CYS HIS PHE GLN THR
SEQRES  28 A  728  ASP LYS SER ASN CYS THR PHE ILE THR LYS GLY ALA TRP
SEQRES  29 A  728  GLU VAL ILE GLY ILE GLU ALA LEU THR SER ASP TYR LEU
SEQRES  30 A  728  TYR TYR ILE SER ASN GLU HIS LYS GLY MET PRO GLY GLY
SEQRES  31 A  728  ARG ASN LEU TYR ARG ILE GLN LEU ASN ASP TYR THR LYS
SEQRES  32 A  728  VAL THR CYS LEU SER CYS GLU LEU ASN PRO GLU ARG CYS
SEQRES  33 A  728  GLN TYR TYR SER ALA SER PHE SER ASN LYS ALA LYS TYR
SEQRES  34 A  728  TYR GLN LEU ARG CYS PHE GLY PRO GLY LEU PRO LEU TYR
SEQRES  35 A  728  THR LEU HIS SER SER SER SER ASP LYS GLU LEU ARG VAL
SEQRES  36 A  728  LEU GLU ASP ASN SER ALA LEU ASP LYS MET LEU GLN ASP
SEQRES  37 A  728  VAL GLN MET PRO SER LYS LYS LEU ASP VAL ILE ASN LEU
SEQRES  38 A  728  HIS GLY THR LYS PHE TRP TYR GLN MET ILE LEU PRO PRO
SEQRES  39 A  728  HIS PHE ASP LYS SER LYS LYS TYR PRO LEU LEU ILE GLU
SEQRES  40 A  728  VAL TYR ALA GLY PRO CYS SER GLN LYS VAL ASP THR VAL
SEQRES  41 A  728  PHE ARG LEU SER TRP ALA THR TYR LEU ALA SER THR GLU
SEQRES  42 A  728  ASN ILE ILE VAL ALA SER PHE ASP GLY ARG GLY SER GLY
SEQRES  43 A  728  TYR GLN GLY ASP LYS ILE MET HIS ALA ILE ASN ARG ARG
SEQRES  44 A  728  LEU GLY THR PHE GLU VAL GLU ASP GLN ILE GLU ALA THR
SEQRES  45 A  728  ARG GLN PHE SER LYS MET GLY PHE VAL ASP ASP LYS ARG
SEQRES  46 A  728  ILE ALA ILE TRP GLY TRP SER TYR GLY GLY TYR VAL THR
SEQRES  47 A  728  SER MET VAL LEU GLY ALA GLY SER GLY VAL PHE LYS CYS
SEQRES  48 A  728  GLY ILE ALA VAL ALA PRO VAL SER LYS TRP GLU TYR TYR
SEQRES  49 A  728  ASP SER VAL TYR THR GLU ARG TYR MET GLY LEU PRO THR
SEQRES  50 A  728  PRO GLU ASP ASN LEU ASP TYR TYR ARG ASN SER THR VAL
SEQRES  51 A  728  MET SER ARG ALA GLU ASN PHE LYS GLN VAL GLU TYR LEU
SEQRES  52 A  728  LEU ILE HIS GLY THR ALA ASP ASP ASN VAL HIS PHE GLN
SEQRES  53 A  728  GLN SER ALA GLN LEU SER LYS ALA LEU VAL ASP ALA GLY
SEQRES  54 A  728  VAL ASP PHE GLN THR MET TRP TYR THR ASP GLU ASP HIS
SEQRES  55 A  728  GLY ILE ALA SER ASN MET ALA HIS GLN HIS ILE TYR THR
SEQRES  56 A  728  HIS MET SER HIS PHE LEU LYS GLN CYS PHE SER LEU PRO
SEQRES   1 B  728  SER ARG ARG THR TYR THR LEU THR ASP TYR LEU LYS SER
SEQRES   2 B  728  THR PHE ARG VAL LYS PHE TYR THR LEU GLN TRP ILE SER
SEQRES   3 B  728  ASP HIS GLU TYR LEU TYR LYS GLN GLU ASN ASN ILE LEU
SEQRES   4 B  728  LEU PHE ASN ALA GLU TYR GLY ASN SER SER ILE PHE LEU
SEQRES   5 B  728  GLU ASN SER THR PHE ASP GLU LEU GLY TYR SER THR ASN
SEQRES   6 B  728  ASP TYR SER VAL SER PRO ASP ARG GLN PHE ILE LEU PHE
SEQRES   7 B  728  GLU TYR ASN TYR VAL LYS GLN TRP ARG HIS SER TYR THR
SEQRES   8 B  728  ALA SER TYR ASP ILE TYR ASP LEU ASN LYS ARG GLN LEU
SEQRES   9 B  728  ILE THR GLU GLU ARG ILE PRO ASN ASN THR GLN TRP ILE
SEQRES  10 B  728  THR TRP SER PRO VAL GLY HIS LYS LEU ALA TYR VAL TRP
SEQRES  11 B  728  ASN ASN ASP ILE TYR VAL LYS ASN GLU PRO ASN LEU SER
SEQRES  12 B  728  SER GLN ARG ILE THR TRP THR GLY LYS GLU ASN VAL ILE
SEQRES  13 B  728  TYR ASN GLY VAL THR ASP TRP VAL TYR GLU GLU GLU VAL
SEQRES  14 B  728  PHE SER ALA TYR SER ALA LEU TRP TRP SER PRO ASN GLY
SEQRES  15 B  728  THR PHE LEU ALA TYR ALA GLN PHE ASN ASP THR GLU VAL
SEQRES  16 B  728  PRO LEU ILE GLU TYR SER PHE TYR SER ASP GLU SER LEU
SEQRES  17 B  728  GLN TYR PRO LYS THR VAL ARG ILE PRO TYR PRO LYS ALA
SEQRES  18 B  728  GLY ALA GLU ASN PRO THR VAL LYS PHE PHE VAL VAL ASP
SEQRES  19 B  728  THR ARG THR LEU SER PRO ASN ALA SER VAL THR SER TYR
SEQRES  20 B  728  GLN ILE VAL PRO PRO ALA SER VAL LEU ILE GLY ASP HIS
SEQRES  21 B  728  TYR LEU CYS GLY VAL THR TRP VAL THR GLU GLU ARG ILE
SEQRES  22 B  728  SER LEU GLN TRP ILE ARG ARG ALA GLN ASN TYR SER ILE
SEQRES  23 B  728  ILE ASP ILE CYS ASP TYR ASP GLU SER THR GLY ARG TRP
SEQRES  24 B  728  ILE SER SER VAL ALA ARG GLN HIS ILE GLU ILE SER THR
SEQRES  25 B  728  THR GLY TRP VAL GLY ARG PHE ARG PRO ALA GLU PRO HIS
SEQRES  26 B  728  PHE THR SER ASP GLY ASN SER PHE TYR LYS ILE ILE SER
SEQRES  27 B  728  ASN GLU GLU GLY TYR LYS HIS ILE CYS HIS PHE GLN THR
SEQRES  28 B  728  ASP LYS SER ASN CYS THR PHE ILE THR LYS GLY ALA TRP
SEQRES  29 B  728  GLU VAL ILE GLY ILE GLU ALA LEU THR SER ASP TYR LEU
SEQRES  30 B  728  TYR TYR ILE SER ASN GLU HIS LYS GLY MET PRO GLY GLY
SEQRES  31 B  728  ARG ASN LEU TYR ARG ILE GLN LEU ASN ASP TYR THR LYS
SEQRES  32 B  728  VAL THR CYS LEU SER CYS GLU LEU ASN PRO GLU ARG CYS
SEQRES  33 B  728  GLN TYR TYR SER ALA SER PHE SER ASN LYS ALA LYS TYR
SEQRES  34 B  728  TYR GLN LEU ARG CYS PHE GLY PRO GLY LEU PRO LEU TYR
SEQRES  35 B  728  THR LEU HIS SER SER SER SER ASP LYS GLU LEU ARG VAL
SEQRES  36 B  728  LEU GLU ASP ASN SER ALA LEU ASP LYS MET LEU GLN ASP
SEQRES  37 B  728  VAL GLN MET PRO SER LYS LYS LEU ASP VAL ILE ASN LEU
SEQRES  38 B  728  HIS GLY THR LYS PHE TRP TYR GLN MET ILE LEU PRO PRO
SEQRES  39 B  728  HIS PHE ASP LYS SER LYS LYS TYR PRO LEU LEU ILE GLU
SEQRES  40 B  728  VAL TYR ALA GLY PRO CYS SER GLN LYS VAL ASP THR VAL
SEQRES  41 B  728  PHE ARG LEU SER TRP ALA THR TYR LEU ALA SER THR GLU
SEQRES  42 B  728  ASN ILE ILE VAL ALA SER PHE ASP GLY ARG GLY SER GLY
SEQRES  43 B  728  TYR GLN GLY ASP LYS ILE MET HIS ALA ILE ASN ARG ARG
SEQRES  44 B  728  LEU GLY THR PHE GLU VAL GLU ASP GLN ILE GLU ALA THR
SEQRES  45 B  728  ARG GLN PHE SER LYS MET GLY PHE VAL ASP ASP LYS ARG
SEQRES  46 B  728  ILE ALA ILE TRP GLY TRP SER TYR GLY GLY TYR VAL THR
SEQRES  47 B  728  SER MET VAL LEU GLY ALA GLY SER GLY VAL PHE LYS CYS
SEQRES  48 B  728  GLY ILE ALA VAL ALA PRO VAL SER LYS TRP GLU TYR TYR
SEQRES  49 B  728  ASP SER VAL TYR THR GLU ARG TYR MET GLY LEU PRO THR
SEQRES  50 B  728  PRO GLU ASP ASN LEU ASP TYR TYR ARG ASN SER THR VAL
SEQRES  51 B  728  MET SER ARG ALA GLU ASN PHE LYS GLN VAL GLU TYR LEU
SEQRES  52 B  728  LEU ILE HIS GLY THR ALA ASP ASP ASN VAL HIS PHE GLN
SEQRES  53 B  728  GLN SER ALA GLN LEU SER LYS ALA LEU VAL ASP ALA GLY
SEQRES  54 B  728  VAL ASP PHE GLN THR MET TRP TYR THR ASP GLU ASP HIS
SEQRES  55 B  728  GLY ILE ALA SER ASN MET ALA HIS GLN HIS ILE TYR THR
SEQRES  56 B  728  HIS MET SER HIS PHE LEU LYS GLN CYS PHE SER LEU PRO
SEQRES   1 C    7  ILE LEU ALA PRO PRO GLU ARG
SEQRES   1 D    7  ILE LEU ALA PRO PRO GLU ARG
HET    NAG  E   1      14
HET    NAG  E   2      14
HET    BMA  E   3      11
HET    MAN  E   4      11
HET    NAG  F   1      14
HET    NAG  F   2      14
HET    NAG  G   1      14
HET    NAG  G   2      14
HET    NAG  H   1      14
HET    NAG  H   2      14
HET    NAG  I   1      14
HET    NAG  I   2      14
HET    NAG  J   1      14
HET    NAG  J   2      14
HET    NAG  K   1      14
HET    NAG  K   2      14
HET    NAG  A 801      14
HET    NAG  A 802      14
HET    NAG  B 801      14
HETNAM     NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE
HETNAM     BMA BETA-D-MANNOPYRANOSE
HETNAM     MAN ALPHA-D-MANNOPYRANOSE
HETSYN     NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA-
HETSYN   2 NAG  D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO-
HETSYN   3 NAG  2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE
HETSYN     BMA BETA-D-MANNOSE; D-MANNOSE; MANNOSE
HETSYN     MAN ALPHA-D-MANNOSE; D-MANNOSE; MANNOSE
FORMUL   5  NAG    17(C8 H15 N O6)
FORMUL   5  BMA    C6 H12 O6
FORMUL   5  MAN    C6 H12 O6
HELIX    1 AA1 THR A   44  LYS A   50  1                                   7
HELIX    2 AA2 ASP A  200  VAL A  207  1                                   8
HELIX    3 AA3 PRO A  290  ILE A  295  1                                   6
HELIX    4 AA4 GLU A  421  MET A  425  5                                   5
HELIX    5 AA5 ASN A  497  GLN A  505  1                                   9
HELIX    6 AA6 SER A  562  THR A  570  1                                   9
HELIX    7 AA7 GLY A  587  HIS A  592  1                                   6
HELIX    8 AA8 THR A  600  SER A  614  1                                  15
HELIX    9 AA9 SER A  630  GLY A  641  1                                  12
HELIX   10 AB1 LYS A  658  TYR A  662  5                                   5
HELIX   11 AB2 ASP A  663  MET A  671  1                                   9
HELIX   12 AB3 ASN A  679  ARG A  684  1                                   6
HELIX   13 AB4 THR A  687  LYS A  696  5                                  10
HELIX   14 AB5 HIS A  712  ASP A  725  1                                  14
HELIX   15 AB6 SER A  744  PHE A  763  1                                  20
HELIX   16 AB7 THR B   44  LYS B   50  1                                   7
HELIX   17 AB8 ASP B  200  VAL B  207  1                                   8
HELIX   18 AB9 PRO B  290  ILE B  295  1                                   6
HELIX   19 AC1 SER B  340  ALA B  342  5                                   3
HELIX   20 AC2 GLU B  421  MET B  425  5                                   5
HELIX   21 AC3 ASN B  497  ASP B  506  1                                  10
HELIX   22 AC4 SER B  562  THR B  570  1                                   9
HELIX   23 AC5 GLY B  587  HIS B  592  1                                   6
HELIX   24 AC6 THR B  600  LYS B  615  1                                  16
HELIX   25 AC7 TYR B  631  GLY B  641  1                                  11
HELIX   26 AC8 LYS B  658  TYR B  662  5                                   5
HELIX   27 AC9 ASP B  663  MET B  671  1                                   9
HELIX   28 AD1 ASN B  679  ASN B  685  1                                   7
HELIX   29 AD2 SER B  686  ARG B  691  5                                   6
HELIX   30 AD3 ALA B  692  VAL B  698  5                                   7
HELIX   31 AD4 HIS B  712  ASP B  725  1                                  14
HELIX   32 AD5 SER B  744  PHE B  763  1                                  20
SHEET    1 AA1 4 GLN A  61  TRP A  62  0
SHEET    2 AA1 4 GLU A  67  GLN A  72 -1  O  LEU A  69   N  GLN A  61
SHEET    3 AA1 4 ASN A  75  ASN A  80 -1  O  LEU A  77   N  TYR A  70
SHEET    4 AA1 4 SER A  86  LEU A  90 -1  O  SER A  87   N  LEU A  78
SHEET    1 AA2 3 TYR A 105  VAL A 107  0
SHEET    2 AA2 3 PHE A 113  LYS A 122 -1  O  LEU A 115   N  SER A 106
SHEET    3 AA2 3 TYR A 128  ASP A 136 -1  O  SER A 131   N  TYR A 118
SHEET    1 AA3 4 TRP A 154  TRP A 157  0
SHEET    2 AA3 4 LEU A 164  VAL A 167 -1  O  ALA A 165   N  THR A 156
SHEET    3 AA3 4 ILE A 172  VAL A 174 -1  O  TYR A 173   N  TYR A 166
SHEET    4 AA3 4 GLN A 183  ARG A 184 -1  O  GLN A 183   N  VAL A 174
SHEET    1 AA4 3 ILE A 194  ASN A 196  0
SHEET    2 AA4 3 PHE A 222  ASN A 229 -1  O  PHE A 228   N  TYR A 195
SHEET    3 AA4 3 LEU A 214  TRP A 216 -1  N  TRP A 215   O  ALA A 224
SHEET    1 AA5 4 ILE A 194  ASN A 196  0
SHEET    2 AA5 4 PHE A 222  ASN A 229 -1  O  PHE A 228   N  TYR A 195
SHEET    3 AA5 4 THR A 265  ASP A 272 -1  O  PHE A 269   N  TYR A 225
SHEET    4 AA5 4 SER A 284  ILE A 287 -1  O  TYR A 285   N  VAL A 270
SHEET    1 AA6 2 LEU A 235  PHE A 240  0
SHEET    2 AA6 2 LYS A 250  PRO A 255 -1  O  LYS A 250   N  PHE A 240
SHEET    1 AA7 4 HIS A 298  THR A 307  0
SHEET    2 AA7 4 ARG A 310  ARG A 317 -1  O  SER A 312   N  THR A 304
SHEET    3 AA7 4 TYR A 322  TYR A 330 -1  O  CYS A 328   N  ILE A 311
SHEET    4 AA7 4 TRP A 337  ILE A 338 -1  O  ILE A 338   N  ASP A 329
SHEET    1 AA8 4 HIS A 298  THR A 307  0
SHEET    2 AA8 4 ARG A 310  ARG A 317 -1  O  SER A 312   N  THR A 304
SHEET    3 AA8 4 TYR A 322  TYR A 330 -1  O  CYS A 328   N  ILE A 311
SHEET    4 AA8 4 GLN A 344  ILE A 348 -1  O  GLU A 347   N  SER A 323
SHEET    1 AA9 4 HIS A 363  PHE A 364  0
SHEET    2 AA9 4 SER A 370  SER A 376 -1  O  TYR A 372   N  HIS A 363
SHEET    3 AA9 4 LYS A 382  GLN A 388 -1  O  CYS A 385   N  LYS A 373
SHEET    4 AA9 4 CYS A 394  PHE A 396 -1  O  THR A 395   N  HIS A 386
SHEET    1 AB1 4 VAL A 404  LEU A 410  0
SHEET    2 AB1 4 TYR A 414  SER A 419 -1  O  TYR A 416   N  ALA A 409
SHEET    3 AB1 4 ASN A 430  GLN A 435 -1  O  TYR A 432   N  TYR A 417
SHEET    4 AB1 4 VAL A 442  CYS A 444 -1  O  THR A 443   N  ARG A 433
SHEET    1 AB2 4 CYS A 454  PHE A 461  0
SHEET    2 AB2 4 TYR A 467  PRO A 475 -1  O  PHE A 473   N  TYR A 456
SHEET    3 AB2 4 LEU A 479  SER A 484 -1  O  THR A 481   N  LEU A 470
SHEET    4 AB2 4 ARG A 492  GLU A 495 -1  O  GLU A 495   N  TYR A 480
SHEET    1 AB3 8 SER A 511  LEU A 519  0
SHEET    2 AB3 8 THR A 522  LEU A 530 -1  O  THR A 522   N  LEU A 519
SHEET    3 AB3 8 ILE A 574  PHE A 578 -1  O  VAL A 575   N  ILE A 529
SHEET    4 AB3 8 TYR A 540  VAL A 546  1  N  LEU A 543   O  ALA A 576
SHEET    5 AB3 8 VAL A 619  TRP A 629  1  O  ASP A 620   N  TYR A 540
SHEET    6 AB3 8 CYS A 649  VAL A 653  1  O  VAL A 653   N  GLY A 628
SHEET    7 AB3 8 LEU A 701  GLY A 705  1  O  LEU A 701   N  ALA A 652
SHEET    8 AB3 8 GLN A 731  TYR A 735  1  O  GLN A 731   N  LEU A 702
SHEET    1 AB4 3 GLU B  67  LYS B  71  0
SHEET    2 AB4 3 ILE B  76  ASN B  80 -1  O  PHE B  79   N  TYR B  68
SHEET    3 AB4 3 SER B  86  LEU B  90 -1  O  SER B  87   N  LEU B  78
SHEET    1 AB5 4 THR B 102  VAL B 107  0
SHEET    2 AB5 4 ILE B 114  LYS B 122 -1  O  GLU B 117   N  ASN B 103
SHEET    3 AB5 4 TYR B 128  ASP B 136 -1  O  SER B 131   N  TYR B 118
SHEET    4 AB5 4 GLN B 141  LEU B 142 -1  N  GLN B 141   O  ASP B 136
SHEET    1 AB6 4 TRP B 154  THR B 156  0
SHEET    2 AB6 4 LEU B 164  TRP B 168 -1  O  VAL B 167   N  TRP B 154
SHEET    3 AB6 4 ASP B 171  LYS B 175 -1  O  ASP B 171   N  TRP B 168
SHEET    4 AB6 4 GLN B 183  ARG B 184 -1  O  GLN B 183   N  VAL B 174
SHEET    1 AB7 4 ILE B 194  ASN B 196  0
SHEET    2 AB7 4 PHE B 222  ASN B 229 -1  O  PHE B 228   N  TYR B 195
SHEET    3 AB7 4 THR B 265  ASP B 272 -1  O  VAL B 271   N  LEU B 223
SHEET    4 AB7 4 SER B 284  ILE B 287 -1  O  ILE B 287   N  PHE B 268
SHEET    1 AB8 2 LEU B 235  PHE B 240  0
SHEET    2 AB8 2 LYS B 250  PRO B 255 -1  O  LYS B 250   N  PHE B 240
SHEET    1 AB9 4 HIS B 298  THR B 307  0
SHEET    2 AB9 4 ARG B 310  ARG B 317 -1  O  GLN B 314   N  CYS B 301
SHEET    3 AB9 4 TYR B 322  ASP B 329 -1  O  ASP B 326   N  LEU B 313
SHEET    4 AB9 4 GLN B 344  ILE B 348 -1  O  GLU B 347   N  SER B 323
SHEET    1 AC1 4 HIS B 363  PHE B 364  0
SHEET    2 AC1 4 SER B 370  SER B 376 -1  O  TYR B 372   N  HIS B 363
SHEET    3 AC1 4 LYS B 382  GLN B 388 -1  O  CYS B 385   N  LYS B 373
SHEET    4 AC1 4 LYS B 391  PHE B 396 -1  O  THR B 395   N  HIS B 386
SHEET    1 AC2 3 VAL B 404  LEU B 410  0
SHEET    2 AC2 3 TYR B 414  SER B 419 -1  O  TYR B 416   N  ALA B 409
SHEET    3 AC2 3 ASN B 430  LEU B 431 -1  O  ASN B 430   N  SER B 419
SHEET    1 AC3 3 VAL B 404  LEU B 410  0
SHEET    2 AC3 3 TYR B 414  SER B 419 -1  O  TYR B 416   N  ALA B 409
SHEET    3 AC3 3 ILE B 434  GLN B 435 -1  O  ILE B 434   N  LEU B 415
SHEET    1 AC4 3 CYS B 454  SER B 458  0
SHEET    2 AC4 3 GLN B 469  PRO B 475 -1  O  GLY B 474   N  GLN B 455
SHEET    3 AC4 3 LEU B 479  LEU B 482 -1  O  LEU B 479   N  CYS B 472
SHEET    1 AC5 8 SER B 511  LEU B 519  0
SHEET    2 AC5 8 THR B 522  LEU B 530 -1  O  LEU B 530   N  SER B 511
SHEET    3 AC5 8 ILE B 574  ASP B 579 -1  O  VAL B 575   N  ILE B 529
SHEET    4 AC5 8 TYR B 540  GLU B 545  1  N  PRO B 541   O  ILE B 574
SHEET    5 AC5 8 VAL B 619  SER B 630  1  O  ASP B 620   N  TYR B 540
SHEET    6 AC5 8 ILE B 651  PRO B 655  1  O  ILE B 651   N  GLY B 628
SHEET    7 AC5 8 LEU B 701  GLY B 705  1  O  ILE B 703   N  ALA B 652
SHEET    8 AC5 8 GLN B 731  TYR B 735  1  O  MET B 733   N  HIS B 704
SSBOND   1 CYS A  385    CYS A  394                          1555   1555  2.04
SSBOND   2 CYS A  444    CYS A  447                          1555   1555  2.03
SSBOND   3 CYS A  454    CYS A  472                          1555   1555  2.03
SSBOND   4 CYS A  649    CYS A  762                          1555   1555  2.03
SSBOND   5 CYS B  385    CYS B  394                          1555   1555  2.03
SSBOND   6 CYS B  444    CYS B  447                          1555   1555  2.03
SSBOND   7 CYS B  454    CYS B  472                          1555   1555  2.03
SSBOND   8 CYS B  649    CYS B  762                          1555   1555  2.03
LINK         ND2 ASN A  92                 C1  NAG A 802     1555   1555  1.46
LINK         ND2 ASN A 229                 C1  NAG G   1     1555   1555  1.43
LINK         ND2 ASN A 279                 C1  NAG A 801     1555   1555  1.45
LINK         ND2 ASN A 321                 C1  NAG F   1     1555   1555  1.44
LINK         ND2 ASN A 685                 C1  NAG E   1     1555   1555  1.44
LINK         ND2 ASN B 150                 C1  NAG H   1     1555   1555  1.44
LINK         ND2 ASN B 229                 C1  NAG B 801     1555   1555  1.45
LINK         ND2 ASN B 279                 C1  NAG K   1     1555   1555  1.46
LINK         ND2 ASN B 321                 C1  NAG J   1     1555   1555  1.44
LINK         ND2 ASN B 685                 C1  NAG I   1     1555   1555  1.45
LINK         O4  NAG E   1                 C1  NAG E   2     1555   1555  1.43
LINK         O4  NAG E   2                 C1  BMA E   3     1555   1555  1.45
LINK         O3  BMA E   3                 C1  MAN E   4     1555   1555  1.47
LINK         O4  NAG F   1                 C1  NAG F   2     1555   1555  1.45
LINK         O4  NAG G   1                 C1  NAG G   2     1555   1555  1.44
LINK         O4  NAG H   1                 C1  NAG H   2     1555   1555  1.45
LINK         O4  NAG I   1                 C1  NAG I   2     1555   1555  1.44
LINK         O4  NAG J   1                 C1  NAG J   2     1555   1555  1.46
LINK         O4  NAG K   1                 C1  NAG K   2     1555   1555  1.43
CISPEP   1 GLY A  474    PRO A  475          0         8.15
CISPEP   2 GLY B  474    PRO B  475          0         2.28
CRYST1  257.340   75.617  121.679  90.00 110.20  90.00 C 1 2 1       8
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.003886  0.000000  0.001430        0.00000
SCALE2      0.000000  0.013225  0.000000        0.00000
SCALE3      0.000000  0.000000  0.008757        0.00000
TER    5942      LEU A 765
TER   11868      PRO B 766
TER   11915      ARG C   7
TER   11971      ARG D   7
MASTER      364    0   19   32   90    0    0    612227    4  286  114
END