longtext: 7xrt-pdb

content
HEADER    HYDROLASE                               11-MAY-22   7XRT
TITLE     BACTEROIDES THETAIOTAOMICRON FERULIC ACID ESTERASE (BT_4077)
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: FERULIC ACID ESTERASE;
COMPND   3 CHAIN: A, B, C, D, E, F, G, H, I, J;
COMPND   4 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: BACTEROIDES THETAIOTAOMICRON VPI-5482;
SOURCE   3 ORGANISM_TAXID: 226186;
SOURCE   4 STRAIN: ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
SOURCE   5 VPI-5482 / E50;
SOURCE   6 GENE: BT_4077;
SOURCE   7 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   8 EXPRESSION_SYSTEM_TAXID: 562
KEYWDS    ESTERASE, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    G.M.DU,Y.L.WANG,F.J.XIN
REVDAT   1   22-NOV-23 7XRT    0
JRNL        AUTH   G.M.DU,Y.L.WANG,F.J.XIN
JRNL        TITL   INSIGHTS INTO THE REGULATORY MECHANISM OF BTFAE ACTIVITY BY
JRNL        TITL 2 OLIGOMERIZATION AND A DISTINCT SUBSTRATE BINDING POCKET
JRNL        TITL 3 ADJACENT TO THE ACTIVE SITE
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   2
REMARK   2 RESOLUTION.    2.01 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX 1.15.2_3472
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : ML
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.01
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 29.35
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.340
REMARK   3   COMPLETENESS FOR RANGE        (%) : 98.6
REMARK   3   NUMBER OF REFLECTIONS             : 229501
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.153
REMARK   3   R VALUE            (WORKING SET) : 0.152
REMARK   3   FREE R VALUE                     : 0.172
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.920
REMARK   3   FREE R VALUE TEST SET COUNT      : 11285
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 29.3510 -  6.2158    0.98     7706   374  0.1557 0.1552
REMARK   3     2  6.2158 -  4.9414    1.00     7533   404  0.1505 0.1785
REMARK   3     3  4.9414 -  4.3190    1.00     7491   383  0.1190 0.1319
REMARK   3     4  4.3190 -  3.9251    1.00     7382   406  0.1238 0.1234
REMARK   3     5  3.9251 -  3.6443    1.00     7397   415  0.1323 0.1450
REMARK   3     6  3.6443 -  3.4298    0.99     7393   368  0.1395 0.1552
REMARK   3     7  3.4298 -  3.2582    0.99     7378   377  0.1505 0.1743
REMARK   3     8  3.2582 -  3.1166    1.00     7348   388  0.1496 0.1702
REMARK   3     9  3.1166 -  2.9967    0.99     7355   379  0.1592 0.1889
REMARK   3    10  2.9967 -  2.8934    0.99     7296   371  0.1606 0.1768
REMARK   3    11  2.8934 -  2.8030    0.99     7351   358  0.1642 0.1831
REMARK   3    12  2.8030 -  2.7229    0.99     7318   371  0.1608 0.1935
REMARK   3    13  2.7229 -  2.6513    0.99     7289   380  0.1710 0.1928
REMARK   3    14  2.6513 -  2.5867    0.99     7294   384  0.1661 0.1872
REMARK   3    15  2.5867 -  2.5279    0.99     7247   399  0.1610 0.1978
REMARK   3    16  2.5279 -  2.4741    0.99     7227   407  0.1638 0.1702
REMARK   3    17  2.4741 -  2.4247    0.99     7244   389  0.1618 0.1894
REMARK   3    18  2.4247 -  2.3789    0.99     7294   372  0.1655 0.2016
REMARK   3    19  2.3789 -  2.3365    0.99     7232   378  0.1706 0.2128
REMARK   3    20  2.3365 -  2.2969    0.99     7222   360  0.1638 0.2039
REMARK   3    21  2.2969 -  2.2598    0.99     7235   347  0.1680 0.1854
REMARK   3    22  2.2598 -  2.2251    0.99     7256   328  0.1725 0.2125
REMARK   3    23  2.2251 -  2.1924    0.99     7218   397  0.1707 0.2156
REMARK   3    24  2.1924 -  2.1615    0.98     7187   387  0.1711 0.1911
REMARK   3    25  2.1615 -  2.1323    0.98     7184   369  0.1704 0.1985
REMARK   3    26  2.1323 -  2.1046    0.98     7204   380  0.1763 0.2179
REMARK   3    27  2.1046 -  2.0783    0.98     7175   387  0.1838 0.2220
REMARK   3    28  2.0783 -  2.0533    0.98     7223   333  0.1968 0.2194
REMARK   3    29  2.0533 -  2.0294    0.98     7188   357  0.1928 0.2218
REMARK   3    30  2.0294 -  2.0070    0.87     6349   337  0.1892 0.2291
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL
REMARK   3   SOLVENT RADIUS     : 1.11
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.160
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 17.060
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 40.03
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :   NULL           NULL
REMARK   3   ANGLE     :   NULL           NULL
REMARK   3   CHIRALITY :   NULL           NULL
REMARK   3   PLANARITY :   NULL           NULL
REMARK   3   DIHEDRAL  :   NULL           NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 7XRT COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 12-MAY-22.
REMARK 100 THE DEPOSITION ID IS D_1300029462.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 06-NOV-19
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 6.0
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : SSRF
REMARK 200  BEAMLINE                       : BL17U1
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.979183
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 315R
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000
REMARK 200  DATA SCALING SOFTWARE          : HKL-2000
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 229659
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.000
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 98.9
REMARK 200  DATA REDUNDANCY                : 12.10
REMARK 200  R MERGE                    (I) : 0.07600
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 10.3000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.00
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.07
REMARK 200  COMPLETENESS FOR SHELL     (%) : 98.1
REMARK 200  DATA REDUNDANCY IN SHELL       : 11.40
REMARK 200  R MERGE FOR SHELL          (I) : 0.67500
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: 5VOL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 56.56
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.83
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.04 M SODIUM CACODYLATE TRIHYDRATE
REMARK 280  (PH 6.0), 60% (V/V) MPD, 0.04 M POTASSIUM CHLORIDE, 0.012 M
REMARK 280  SPERMINE TETRAHYDROCHLORIDE, 0.02 M TRIMETHYLAMINE HYDROCHLORIDE,
REMARK 280  VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 293.15K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X+1/2,-Y,Z+1/2
REMARK 290       3555   -X,Y+1/2,-Z+1/2
REMARK 290       4555   X+1/2,-Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       56.69250
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       96.02800
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       80.08200
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       96.02800
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       56.69250
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       80.08200
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DECAMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DECAMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 23210 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 96160 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -244.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I, J
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A    -2
REMARK 465     GLY A    -1
REMARK 465     SER A     0
REMARK 465     SER A     1
REMARK 465     HIS A     2
REMARK 465     HIS A     3
REMARK 465     HIS A     4
REMARK 465     HIS A     5
REMARK 465     HIS A     6
REMARK 465     HIS A     7
REMARK 465     SER A     8
REMARK 465     SER A     9
REMARK 465     GLY A    10
REMARK 465     LEU A    11
REMARK 465     VAL A    12
REMARK 465     PRO A    13
REMARK 465     ARG A    14
REMARK 465     GLY A    15
REMARK 465     SER A    16
REMARK 465     HIS A    17
REMARK 465     MET A    18
REMARK 465     LEU A    19
REMARK 465     GLU A    20
REMARK 465     MET B    -2
REMARK 465     GLY B    -1
REMARK 465     SER B     0
REMARK 465     SER B     1
REMARK 465     HIS B     2
REMARK 465     HIS B     3
REMARK 465     HIS B     4
REMARK 465     HIS B     5
REMARK 465     HIS B     6
REMARK 465     HIS B     7
REMARK 465     SER B     8
REMARK 465     SER B     9
REMARK 465     GLY B    10
REMARK 465     LEU B    11
REMARK 465     VAL B    12
REMARK 465     PRO B    13
REMARK 465     ARG B    14
REMARK 465     GLY B    15
REMARK 465     SER B    16
REMARK 465     HIS B    17
REMARK 465     MET B    18
REMARK 465     LEU B    19
REMARK 465     GLU B    20
REMARK 465     MET C    -2
REMARK 465     GLY C    -1
REMARK 465     SER C     0
REMARK 465     SER C     1
REMARK 465     HIS C     2
REMARK 465     HIS C     3
REMARK 465     HIS C     4
REMARK 465     HIS C     5
REMARK 465     HIS C     6
REMARK 465     HIS C     7
REMARK 465     SER C     8
REMARK 465     SER C     9
REMARK 465     GLY C    10
REMARK 465     LEU C    11
REMARK 465     VAL C    12
REMARK 465     PRO C    13
REMARK 465     ARG C    14
REMARK 465     GLY C    15
REMARK 465     SER C    16
REMARK 465     HIS C    17
REMARK 465     MET C    18
REMARK 465     LEU C    19
REMARK 465     GLU C    20
REMARK 465     MET D    -2
REMARK 465     GLY D    -1
REMARK 465     SER D     0
REMARK 465     SER D     1
REMARK 465     HIS D     2
REMARK 465     HIS D     3
REMARK 465     HIS D     4
REMARK 465     HIS D     5
REMARK 465     HIS D     6
REMARK 465     HIS D     7
REMARK 465     SER D     8
REMARK 465     SER D     9
REMARK 465     GLY D    10
REMARK 465     LEU D    11
REMARK 465     VAL D    12
REMARK 465     PRO D    13
REMARK 465     ARG D    14
REMARK 465     GLY D    15
REMARK 465     SER D    16
REMARK 465     HIS D    17
REMARK 465     MET D    18
REMARK 465     LEU D    19
REMARK 465     GLU D    20
REMARK 465     MET E    -2
REMARK 465     GLY E    -1
REMARK 465     SER E     0
REMARK 465     SER E     1
REMARK 465     HIS E     2
REMARK 465     HIS E     3
REMARK 465     HIS E     4
REMARK 465     HIS E     5
REMARK 465     HIS E     6
REMARK 465     HIS E     7
REMARK 465     SER E     8
REMARK 465     SER E     9
REMARK 465     GLY E    10
REMARK 465     LEU E    11
REMARK 465     VAL E    12
REMARK 465     PRO E    13
REMARK 465     ARG E    14
REMARK 465     GLY E    15
REMARK 465     SER E    16
REMARK 465     HIS E    17
REMARK 465     MET E    18
REMARK 465     LEU E    19
REMARK 465     GLU E    20
REMARK 465     MET F    -2
REMARK 465     GLY F    -1
REMARK 465     SER F     0
REMARK 465     SER F     1
REMARK 465     HIS F     2
REMARK 465     HIS F     3
REMARK 465     HIS F     4
REMARK 465     HIS F     5
REMARK 465     HIS F     6
REMARK 465     HIS F     7
REMARK 465     SER F     8
REMARK 465     SER F     9
REMARK 465     GLY F    10
REMARK 465     LEU F    11
REMARK 465     VAL F    12
REMARK 465     PRO F    13
REMARK 465     ARG F    14
REMARK 465     GLY F    15
REMARK 465     SER F    16
REMARK 465     HIS F    17
REMARK 465     MET F    18
REMARK 465     LEU F    19
REMARK 465     GLU F    20
REMARK 465     MET G    -2
REMARK 465     GLY G    -1
REMARK 465     SER G     0
REMARK 465     SER G     1
REMARK 465     HIS G     2
REMARK 465     HIS G     3
REMARK 465     HIS G     4
REMARK 465     HIS G     5
REMARK 465     HIS G     6
REMARK 465     HIS G     7
REMARK 465     SER G     8
REMARK 465     SER G     9
REMARK 465     GLY G    10
REMARK 465     LEU G    11
REMARK 465     VAL G    12
REMARK 465     PRO G    13
REMARK 465     ARG G    14
REMARK 465     GLY G    15
REMARK 465     SER G    16
REMARK 465     HIS G    17
REMARK 465     MET G    18
REMARK 465     LEU G    19
REMARK 465     GLU G    20
REMARK 465     MET H    -2
REMARK 465     GLY H    -1
REMARK 465     SER H     0
REMARK 465     SER H     1
REMARK 465     HIS H     2
REMARK 465     HIS H     3
REMARK 465     HIS H     4
REMARK 465     HIS H     5
REMARK 465     HIS H     6
REMARK 465     HIS H     7
REMARK 465     SER H     8
REMARK 465     SER H     9
REMARK 465     GLY H    10
REMARK 465     LEU H    11
REMARK 465     VAL H    12
REMARK 465     PRO H    13
REMARK 465     ARG H    14
REMARK 465     GLY H    15
REMARK 465     SER H    16
REMARK 465     HIS H    17
REMARK 465     MET H    18
REMARK 465     LEU H    19
REMARK 465     GLU H    20
REMARK 465     MET I    -2
REMARK 465     GLY I    -1
REMARK 465     SER I     0
REMARK 465     SER I     1
REMARK 465     HIS I     2
REMARK 465     HIS I     3
REMARK 465     HIS I     4
REMARK 465     HIS I     5
REMARK 465     HIS I     6
REMARK 465     HIS I     7
REMARK 465     SER I     8
REMARK 465     SER I     9
REMARK 465     GLY I    10
REMARK 465     LEU I    11
REMARK 465     VAL I    12
REMARK 465     PRO I    13
REMARK 465     ARG I    14
REMARK 465     GLY I    15
REMARK 465     SER I    16
REMARK 465     HIS I    17
REMARK 465     MET I    18
REMARK 465     LEU I    19
REMARK 465     GLU I    20
REMARK 465     MET J    -2
REMARK 465     GLY J    -1
REMARK 465     SER J     0
REMARK 465     SER J     1
REMARK 465     HIS J     2
REMARK 465     HIS J     3
REMARK 465     HIS J     4
REMARK 465     HIS J     5
REMARK 465     HIS J     6
REMARK 465     HIS J     7
REMARK 465     SER J     8
REMARK 465     SER J     9
REMARK 465     GLY J    10
REMARK 465     LEU J    11
REMARK 465     VAL J    12
REMARK 465     PRO J    13
REMARK 465     ARG J    14
REMARK 465     GLY J    15
REMARK 465     SER J    16
REMARK 465     HIS J    17
REMARK 465     MET J    18
REMARK 465     LEU J    19
REMARK 465     GLU J    20
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     GLN A  21    CG   CD   OE1  NE2
REMARK 470     LYS A 193    CG   CD   CE   NZ
REMARK 470     GLU A 197    CG   CD   OE1  OE2
REMARK 470     GLU A 218    CG   CD   OE1  OE2
REMARK 470     GLN B  21    CG   CD   OE1  NE2
REMARK 470     LYS B 193    CG   CD   CE   NZ
REMARK 470     GLU B 197    CG   CD   OE1  OE2
REMARK 470     GLU B 218    CG   CD   OE1  OE2
REMARK 470     GLN C  21    CG   CD   OE1  NE2
REMARK 470     GLN C  22    CG   CD   OE1  NE2
REMARK 470     GLU C 218    CG   CD   OE1  OE2
REMARK 470     GLN D  21    CG   CD   OE1  NE2
REMARK 470     GLN D  22    CG   CD   OE1  NE2
REMARK 470     SER D 192    OG
REMARK 470     LYS D 193    CG   CD   CE   NZ
REMARK 470     GLU D 197    CG   CD   OE1  OE2
REMARK 470     LYS D 198    CG   CD   CE   NZ
REMARK 470     LYS D 199    CG   CD   CE   NZ
REMARK 470     GLU D 218    CG   CD   OE1  OE2
REMARK 470     GLN E  21    CG   CD   OE1  NE2
REMARK 470     GLN E  22    CG   CD   OE1  NE2
REMARK 470     LYS E 193    CG   CD   CE   NZ
REMARK 470     GLU E 218    CG   CD   OE1  OE2
REMARK 470     GLN F  21    CG   CD   OE1  NE2
REMARK 470     GLN F  22    CG   CD   OE1  NE2
REMARK 470     LYS F 193    CG   CD   CE   NZ
REMARK 470     GLU F 197    CG   CD   OE1  OE2
REMARK 470     GLN G  21    CG   CD   OE1  NE2
REMARK 470     GLN G  22    CG   CD   OE1  NE2
REMARK 470     LEU G 191    CG   CD1  CD2
REMARK 470     LYS G 193    CG   CD   CE   NZ
REMARK 470     VAL G 194    CG1  CG2
REMARK 470     GLU G 197    CG   CD   OE1  OE2
REMARK 470     GLU G 218    CG   CD   OE1  OE2
REMARK 470     GLN H  21    CG   CD   OE1  NE2
REMARK 470     GLN H  22    CG   CD   OE1  NE2
REMARK 470     LEU H 191    CG   CD1  CD2
REMARK 470     LYS H 193    CG   CD   CE   NZ
REMARK 470     VAL H 194    CG1  CG2
REMARK 470     GLU H 197    CG   CD   OE1  OE2
REMARK 470     GLU H 218    CG   CD   OE1  OE2
REMARK 470     GLN I  21    CG   CD   OE1  NE2
REMARK 470     GLN I  22    CG   CD   OE1  NE2
REMARK 470     LYS I 193    CG   CD   CE   NZ
REMARK 470     GLU I 197    CG   CD   OE1  OE2
REMARK 470     GLU I 218    CG   CD   OE1  OE2
REMARK 470     GLN J  21    CG   CD   OE1  NE2
REMARK 470     GLN J  22    CG   CD   OE1  NE2
REMARK 470     LYS J 193    CG   CD   CE   NZ
REMARK 470     GLU J 197    CG   CD   OE1  OE2
REMARK 470     GLU J 218    CG   CD   OE1  OE2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    ASN A  69     -155.55   -128.26
REMARK 500    VAL A 105      -61.99     75.90
REMARK 500    TYR A 117       86.64   -156.16
REMARK 500    SER A 150     -118.58     55.66
REMARK 500    SER A 264     -168.91   -123.66
REMARK 500    GLN A 287      167.70     65.38
REMARK 500    ASN B  69     -154.07   -129.21
REMARK 500    VAL B 105      -62.04     75.07
REMARK 500    TYR B 117       85.33   -156.55
REMARK 500    SER B 150     -118.61     55.86
REMARK 500    SER B 264     -168.50   -123.29
REMARK 500    GLN B 287      167.72     65.04
REMARK 500    ASN C  69     -155.67   -128.53
REMARK 500    VAL C 105      -60.45     75.42
REMARK 500    TYR C 117       84.42   -154.48
REMARK 500    SER C 150     -117.75     54.83
REMARK 500    GLN C 287      167.52     65.09
REMARK 500    ASN D  69     -155.33   -129.14
REMARK 500    VAL D 105      -61.20     73.52
REMARK 500    TYR D 117       86.43   -158.38
REMARK 500    SER D 150     -117.13     54.30
REMARK 500    GLN D 287      166.20     65.15
REMARK 500    ASN E  69     -154.26   -128.61
REMARK 500    VAL E 105      -62.37     75.50
REMARK 500    TYR E 117       85.80   -156.15
REMARK 500    SER E 150     -117.28     54.86
REMARK 500    SER E 264     -169.93   -123.41
REMARK 500    GLN E 287      167.38     64.39
REMARK 500    ASN F  69     -155.94   -128.91
REMARK 500    VAL F 105      -61.61     76.62
REMARK 500    TYR F 117       84.98   -154.72
REMARK 500    SER F 150     -118.15     54.73
REMARK 500    SER F 264     -169.29   -123.24
REMARK 500    GLN F 287      167.05     65.56
REMARK 500    ASN G  69     -157.11   -127.91
REMARK 500    VAL G 105      -63.27     76.48
REMARK 500    TYR G 117       84.50   -154.70
REMARK 500    SER G 150     -119.72     55.63
REMARK 500    SER G 264     -167.46   -123.36
REMARK 500    GLN G 287      167.71     65.40
REMARK 500    ASN H  69     -156.05   -127.90
REMARK 500    VAL H 105      -61.99     76.16
REMARK 500    TYR H 117       86.65   -155.76
REMARK 500    SER H 150     -118.91     55.79
REMARK 500    SER H 264     -168.95   -124.19
REMARK 500    GLN H 287      168.21     66.76
REMARK 500    ASN I  69     -154.41   -128.49
REMARK 500    VAL I 105      -61.45     75.81
REMARK 500    TYR I 117       85.48   -157.03
REMARK 500    SER I 150     -118.85     56.29
REMARK 500
REMARK 500 THIS ENTRY HAS      58 RAMACHANDRAN OUTLIERS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 525
REMARK 525 SOLVENT
REMARK 525
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 525 NUMBER; I=INSERTION CODE):
REMARK 525
REMARK 525  M RES CSSEQI
REMARK 525    HOH A 611        DISTANCE =  6.11 ANGSTROMS
REMARK 525    HOH A 612        DISTANCE =  6.70 ANGSTROMS
REMARK 525    HOH B 612        DISTANCE =  6.44 ANGSTROMS
REMARK 525    HOH C 638        DISTANCE =  6.19 ANGSTROMS
REMARK 525    HOH D 534        DISTANCE =  6.63 ANGSTROMS
REMARK 525    HOH D 535        DISTANCE =  6.72 ANGSTROMS
REMARK 525    HOH E 612        DISTANCE =  6.51 ANGSTROMS
REMARK 525    HOH F 603        DISTANCE =  6.67 ANGSTROMS
REMARK 525    HOH H 547        DISTANCE =  6.65 ANGSTROMS
REMARK 525    HOH I 599        DISTANCE =  5.88 ANGSTROMS
REMARK 525    HOH I 600        DISTANCE =  6.48 ANGSTROMS
REMARK 525    HOH J 574        DISTANCE =  6.75 ANGSTROMS
REMARK 620
REMARK 620 METAL COORDINATION
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA A 301  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 ASP A 234   OD1
REMARK 620 2 ASP A 234   OD2  48.4
REMARK 620 3 ASP A 235   OD1  79.5  89.3
REMARK 620 4 ASP A 235   OD2  73.4 115.3  50.0
REMARK 620 5 ASP A 262   OD1  80.6 105.6 136.3  87.0
REMARK 620 6 GLU B 257   OE2 114.2  77.8 142.5 164.5  81.2
REMARK 620 N                    1     2     3     4     5
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA B 301  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 GLU A 257   OE2
REMARK 620 2 ASP B 234   OD1 114.2
REMARK 620 3 ASP B 234   OD2  76.9  50.0
REMARK 620 4 ASP B 235   OD1 145.3  77.7  89.5
REMARK 620 5 ASP B 235   OD2 163.1  72.0 116.1  49.8
REMARK 620 6 ASP B 262   OD1  80.1  80.5 105.9 134.7  85.8
REMARK 620 N                    1     2     3     4     5
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA C 301  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 ASP C 234   OD1
REMARK 620 2 ASP C 234   OD2  48.2
REMARK 620 3 ASP C 235   OD1  76.8  86.1
REMARK 620 4 ASP C 235   OD2  74.2 115.6  50.3
REMARK 620 5 ASP C 262   OD1  82.2 106.9 137.0  88.1
REMARK 620 6 GLU E 257   OE2 115.2  78.4 141.2 164.9  81.8
REMARK 620 N                    1     2     3     4     5
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA E 301  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 GLU C 257   OE1
REMARK 620 2 ASP E 234   OD1 114.7
REMARK 620 3 ASP E 234   OD2  78.7  49.2
REMARK 620 4 ASP E 235   OD1 142.7  78.1  86.6
REMARK 620 5 ASP E 235   OD2 165.6  73.4 114.4  48.4
REMARK 620 6 ASP E 262   OD1  82.1  80.8 108.2 135.2  87.8
REMARK 620 N                    1     2     3     4     5
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA D 301  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 ASP D 234   OD1
REMARK 620 2 ASP D 234   OD2  49.6
REMARK 620 3 ASP D 235   OD1  77.8  83.1
REMARK 620 4 ASP D 235   OD2  72.8 113.5  51.2
REMARK 620 5 ASP D 262   OD1  79.3 109.0 135.9  86.1
REMARK 620 6 GLU G 257   OE2 115.2  79.6 139.9 165.8  84.1
REMARK 620 N                    1     2     3     4     5
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA G 301  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 GLU D 257   OE2
REMARK 620 2 ASP G 234   OD1 114.6
REMARK 620 3 ASP G 234   OD2  78.9  48.4
REMARK 620 4 ASP G 235   OD1 142.7  78.8  87.6
REMARK 620 5 ASP G 235   OD2 161.8  76.6 118.0  50.7
REMARK 620 6 ASP G 262   OD1  80.4  81.0 106.3 136.8  87.6
REMARK 620 N                    1     2     3     4     5
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA F 301  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 ASP F 234   OD1
REMARK 620 2 ASP F 234   OD2  48.1
REMARK 620 3 ASP F 235   OD1  79.4  87.3
REMARK 620 4 ASP F 235   OD2  73.9 114.9  50.6
REMARK 620 5 ASP F 262   OD1  78.3 105.6 134.7  85.4
REMARK 620 6 GLU H 257   OE2 110.7  77.9 146.0 162.3  79.1
REMARK 620 N                    1     2     3     4     5
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA H 301  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 GLU F 257   OE2
REMARK 620 2 ASP H 234   OD1 115.1
REMARK 620 3 ASP H 234   OD2  79.2  49.6
REMARK 620 4 ASP H 235   OD1 143.0  79.9  88.2
REMARK 620 5 ASP H 235   OD2 162.3  75.0 117.0  50.2
REMARK 620 6 ASP H 262   OD1  81.6  80.8 108.4 135.4  86.0
REMARK 620 N                    1     2     3     4     5
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA I 301  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 ASP I 234   OD1
REMARK 620 2 ASP I 234   OD2  50.1
REMARK 620 3 ASP I 235   OD1  78.3  86.6
REMARK 620 4 ASP I 235   OD2  73.1 116.3  52.1
REMARK 620 5 ASP I 262   OD1  79.6 106.7 136.7  86.0
REMARK 620 N                    1     2     3     4
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA J 301  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 GLU I 257   OE2
REMARK 620 2 ASP J 234   OD1 112.8
REMARK 620 3 ASP J 234   OD2  78.7  49.1
REMARK 620 4 ASP J 235   OD1 144.4  80.1  87.7
REMARK 620 5 ASP J 235   OD2 162.3  75.9 116.8  49.9
REMARK 620 6 ASP J 262   OD1  80.8  80.8 109.3 134.8  85.7
REMARK 620 N                    1     2     3     4     5
DBREF  7XRT A   21   288  UNP    Q8A0E4   Q8A0E4_BACTN    21    288
DBREF  7XRT B   21   288  UNP    Q8A0E4   Q8A0E4_BACTN    21    288
DBREF  7XRT C   21   288  UNP    Q8A0E4   Q8A0E4_BACTN    21    288
DBREF  7XRT D   21   288  UNP    Q8A0E4   Q8A0E4_BACTN    21    288
DBREF  7XRT E   21   288  UNP    Q8A0E4   Q8A0E4_BACTN    21    288
DBREF  7XRT F   21   288  UNP    Q8A0E4   Q8A0E4_BACTN    21    288
DBREF  7XRT G   21   288  UNP    Q8A0E4   Q8A0E4_BACTN    21    288
DBREF  7XRT H   21   288  UNP    Q8A0E4   Q8A0E4_BACTN    21    288
DBREF  7XRT I   21   288  UNP    Q8A0E4   Q8A0E4_BACTN    21    288
DBREF  7XRT J   21   288  UNP    Q8A0E4   Q8A0E4_BACTN    21    288
SEQADV 7XRT MET A   -2  UNP  Q8A0E4              INITIATING METHIONINE
SEQADV 7XRT GLY A   -1  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER A    0  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER A    1  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS A    2  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS A    3  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS A    4  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS A    5  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS A    6  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS A    7  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER A    8  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER A    9  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT GLY A   10  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT LEU A   11  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT VAL A   12  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT PRO A   13  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT ARG A   14  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT GLY A   15  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER A   16  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS A   17  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT MET A   18  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT LEU A   19  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT GLU A   20  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT MET B   -2  UNP  Q8A0E4              INITIATING METHIONINE
SEQADV 7XRT GLY B   -1  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER B    0  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER B    1  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS B    2  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS B    3  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS B    4  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS B    5  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS B    6  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS B    7  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER B    8  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER B    9  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT GLY B   10  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT LEU B   11  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT VAL B   12  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT PRO B   13  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT ARG B   14  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT GLY B   15  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER B   16  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS B   17  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT MET B   18  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT LEU B   19  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT GLU B   20  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT MET C   -2  UNP  Q8A0E4              INITIATING METHIONINE
SEQADV 7XRT GLY C   -1  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER C    0  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER C    1  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS C    2  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS C    3  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS C    4  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS C    5  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS C    6  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS C    7  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER C    8  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER C    9  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT GLY C   10  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT LEU C   11  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT VAL C   12  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT PRO C   13  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT ARG C   14  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT GLY C   15  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER C   16  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS C   17  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT MET C   18  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT LEU C   19  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT GLU C   20  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT MET D   -2  UNP  Q8A0E4              INITIATING METHIONINE
SEQADV 7XRT GLY D   -1  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER D    0  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER D    1  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS D    2  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS D    3  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS D    4  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS D    5  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS D    6  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS D    7  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER D    8  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER D    9  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT GLY D   10  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT LEU D   11  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT VAL D   12  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT PRO D   13  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT ARG D   14  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT GLY D   15  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER D   16  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS D   17  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT MET D   18  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT LEU D   19  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT GLU D   20  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT MET E   -2  UNP  Q8A0E4              INITIATING METHIONINE
SEQADV 7XRT GLY E   -1  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER E    0  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER E    1  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS E    2  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS E    3  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS E    4  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS E    5  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS E    6  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS E    7  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER E    8  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER E    9  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT GLY E   10  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT LEU E   11  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT VAL E   12  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT PRO E   13  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT ARG E   14  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT GLY E   15  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER E   16  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS E   17  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT MET E   18  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT LEU E   19  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT GLU E   20  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT MET F   -2  UNP  Q8A0E4              INITIATING METHIONINE
SEQADV 7XRT GLY F   -1  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER F    0  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER F    1  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS F    2  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS F    3  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS F    4  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS F    5  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS F    6  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS F    7  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER F    8  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER F    9  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT GLY F   10  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT LEU F   11  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT VAL F   12  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT PRO F   13  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT ARG F   14  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT GLY F   15  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER F   16  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS F   17  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT MET F   18  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT LEU F   19  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT GLU F   20  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT MET G   -2  UNP  Q8A0E4              INITIATING METHIONINE
SEQADV 7XRT GLY G   -1  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER G    0  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER G    1  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS G    2  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS G    3  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS G    4  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS G    5  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS G    6  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS G    7  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER G    8  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER G    9  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT GLY G   10  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT LEU G   11  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT VAL G   12  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT PRO G   13  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT ARG G   14  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT GLY G   15  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER G   16  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS G   17  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT MET G   18  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT LEU G   19  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT GLU G   20  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT MET H   -2  UNP  Q8A0E4              INITIATING METHIONINE
SEQADV 7XRT GLY H   -1  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER H    0  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER H    1  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS H    2  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS H    3  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS H    4  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS H    5  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS H    6  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS H    7  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER H    8  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER H    9  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT GLY H   10  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT LEU H   11  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT VAL H   12  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT PRO H   13  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT ARG H   14  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT GLY H   15  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER H   16  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS H   17  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT MET H   18  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT LEU H   19  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT GLU H   20  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT MET I   -2  UNP  Q8A0E4              INITIATING METHIONINE
SEQADV 7XRT GLY I   -1  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER I    0  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER I    1  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS I    2  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS I    3  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS I    4  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS I    5  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS I    6  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS I    7  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER I    8  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER I    9  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT GLY I   10  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT LEU I   11  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT VAL I   12  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT PRO I   13  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT ARG I   14  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT GLY I   15  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER I   16  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS I   17  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT MET I   18  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT LEU I   19  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT GLU I   20  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT MET J   -2  UNP  Q8A0E4              INITIATING METHIONINE
SEQADV 7XRT GLY J   -1  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER J    0  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER J    1  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS J    2  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS J    3  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS J    4  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS J    5  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS J    6  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS J    7  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER J    8  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER J    9  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT GLY J   10  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT LEU J   11  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT VAL J   12  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT PRO J   13  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT ARG J   14  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT GLY J   15  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT SER J   16  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT HIS J   17  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT MET J   18  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT LEU J   19  UNP  Q8A0E4              EXPRESSION TAG
SEQADV 7XRT GLU J   20  UNP  Q8A0E4              EXPRESSION TAG
SEQRES   1 A  291  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES   2 A  291  LEU VAL PRO ARG GLY SER HIS MET LEU GLU GLN GLN GLY
SEQRES   3 A  291  LYS VAL TYR GLU THR ARG THR VAL LYS SER LYS ILE LEU
SEQRES   4 A  291  GLY MET GLU ARG SER TYR SER ILE TYR LEU PRO ALA GLY
SEQRES   5 A  291  TYR ASP GLU GLY ASP GLY SER TYR PRO VAL LEU TYR LEU
SEQRES   6 A  291  LEU HIS GLY LEU GLY ASP ASN HIS THR GLY TRP VAL GLN
SEQRES   7 A  291  PHE GLY GLN VAL GLN TYR ILE ALA ASP LYS ALA ILE ALA
SEQRES   8 A  291  GLU GLY LYS SER ALA PRO MET ILE ILE VAL MET PRO ASP
SEQRES   9 A  291  ALA ASP THR VAL HIS LYS GLY TYR PHE ASN LEU LEU ASP
SEQRES  10 A  291  GLY THR TYR ASN TYR GLU ASP PHE PHE PHE GLN GLU LEU
SEQRES  11 A  291  ILE PRO HIS ILE GLU LYS THR TYR ARG VAL ARG ALA GLU
SEQRES  12 A  291  SER ARG TYR ARG ALA ILE SER GLY LEU SER MET GLY GLY
SEQRES  13 A  291  GLY GLY ALA LEU PHE TYR ALA LEU HIS TYR PRO GLU MET
SEQRES  14 A  291  PHE VAL ALA VAL ALA PRO LEU SER ALA VAL GLY GLY ALA
SEQRES  15 A  291  TRP THR PHE ASP GLN MET LYS ASN GLN SER ASP LEU SER
SEQRES  16 A  291  LYS VAL SER GLU GLU LYS LYS ALA GLU VAL LEU GLY GLN
SEQRES  17 A  291  MET ASP ILE GLN THR ILE LEU GLU LYS SER PRO LYS GLU
SEQRES  18 A  291  LYS LEU ASP ARG ILE LYS TRP ILE ARG TRP TYR ILE SER
SEQRES  19 A  291  CYS GLY ASP ASP ASP PHE LEU SER VAL THR ASN CYS LEU
SEQRES  20 A  291  LEU HIS ASN THR LEU LEU GLN HIS GLN VAL GLY HIS GLU
SEQRES  21 A  291  PHE ARG MET LYS ASP GLY SER HIS SER TRP THR TYR TRP
SEQRES  22 A  291  ARG MET GLU LEU PRO GLU VAL MET ARG PHE VAL SER ARG
SEQRES  23 A  291  ILE PHE THR GLN TYR
SEQRES   1 B  291  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES   2 B  291  LEU VAL PRO ARG GLY SER HIS MET LEU GLU GLN GLN GLY
SEQRES   3 B  291  LYS VAL TYR GLU THR ARG THR VAL LYS SER LYS ILE LEU
SEQRES   4 B  291  GLY MET GLU ARG SER TYR SER ILE TYR LEU PRO ALA GLY
SEQRES   5 B  291  TYR ASP GLU GLY ASP GLY SER TYR PRO VAL LEU TYR LEU
SEQRES   6 B  291  LEU HIS GLY LEU GLY ASP ASN HIS THR GLY TRP VAL GLN
SEQRES   7 B  291  PHE GLY GLN VAL GLN TYR ILE ALA ASP LYS ALA ILE ALA
SEQRES   8 B  291  GLU GLY LYS SER ALA PRO MET ILE ILE VAL MET PRO ASP
SEQRES   9 B  291  ALA ASP THR VAL HIS LYS GLY TYR PHE ASN LEU LEU ASP
SEQRES  10 B  291  GLY THR TYR ASN TYR GLU ASP PHE PHE PHE GLN GLU LEU
SEQRES  11 B  291  ILE PRO HIS ILE GLU LYS THR TYR ARG VAL ARG ALA GLU
SEQRES  12 B  291  SER ARG TYR ARG ALA ILE SER GLY LEU SER MET GLY GLY
SEQRES  13 B  291  GLY GLY ALA LEU PHE TYR ALA LEU HIS TYR PRO GLU MET
SEQRES  14 B  291  PHE VAL ALA VAL ALA PRO LEU SER ALA VAL GLY GLY ALA
SEQRES  15 B  291  TRP THR PHE ASP GLN MET LYS ASN GLN SER ASP LEU SER
SEQRES  16 B  291  LYS VAL SER GLU GLU LYS LYS ALA GLU VAL LEU GLY GLN
SEQRES  17 B  291  MET ASP ILE GLN THR ILE LEU GLU LYS SER PRO LYS GLU
SEQRES  18 B  291  LYS LEU ASP ARG ILE LYS TRP ILE ARG TRP TYR ILE SER
SEQRES  19 B  291  CYS GLY ASP ASP ASP PHE LEU SER VAL THR ASN CYS LEU
SEQRES  20 B  291  LEU HIS ASN THR LEU LEU GLN HIS GLN VAL GLY HIS GLU
SEQRES  21 B  291  PHE ARG MET LYS ASP GLY SER HIS SER TRP THR TYR TRP
SEQRES  22 B  291  ARG MET GLU LEU PRO GLU VAL MET ARG PHE VAL SER ARG
SEQRES  23 B  291  ILE PHE THR GLN TYR
SEQRES   1 C  291  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES   2 C  291  LEU VAL PRO ARG GLY SER HIS MET LEU GLU GLN GLN GLY
SEQRES   3 C  291  LYS VAL TYR GLU THR ARG THR VAL LYS SER LYS ILE LEU
SEQRES   4 C  291  GLY MET GLU ARG SER TYR SER ILE TYR LEU PRO ALA GLY
SEQRES   5 C  291  TYR ASP GLU GLY ASP GLY SER TYR PRO VAL LEU TYR LEU
SEQRES   6 C  291  LEU HIS GLY LEU GLY ASP ASN HIS THR GLY TRP VAL GLN
SEQRES   7 C  291  PHE GLY GLN VAL GLN TYR ILE ALA ASP LYS ALA ILE ALA
SEQRES   8 C  291  GLU GLY LYS SER ALA PRO MET ILE ILE VAL MET PRO ASP
SEQRES   9 C  291  ALA ASP THR VAL HIS LYS GLY TYR PHE ASN LEU LEU ASP
SEQRES  10 C  291  GLY THR TYR ASN TYR GLU ASP PHE PHE PHE GLN GLU LEU
SEQRES  11 C  291  ILE PRO HIS ILE GLU LYS THR TYR ARG VAL ARG ALA GLU
SEQRES  12 C  291  SER ARG TYR ARG ALA ILE SER GLY LEU SER MET GLY GLY
SEQRES  13 C  291  GLY GLY ALA LEU PHE TYR ALA LEU HIS TYR PRO GLU MET
SEQRES  14 C  291  PHE VAL ALA VAL ALA PRO LEU SER ALA VAL GLY GLY ALA
SEQRES  15 C  291  TRP THR PHE ASP GLN MET LYS ASN GLN SER ASP LEU SER
SEQRES  16 C  291  LYS VAL SER GLU GLU LYS LYS ALA GLU VAL LEU GLY GLN
SEQRES  17 C  291  MET ASP ILE GLN THR ILE LEU GLU LYS SER PRO LYS GLU
SEQRES  18 C  291  LYS LEU ASP ARG ILE LYS TRP ILE ARG TRP TYR ILE SER
SEQRES  19 C  291  CYS GLY ASP ASP ASP PHE LEU SER VAL THR ASN CYS LEU
SEQRES  20 C  291  LEU HIS ASN THR LEU LEU GLN HIS GLN VAL GLY HIS GLU
SEQRES  21 C  291  PHE ARG MET LYS ASP GLY SER HIS SER TRP THR TYR TRP
SEQRES  22 C  291  ARG MET GLU LEU PRO GLU VAL MET ARG PHE VAL SER ARG
SEQRES  23 C  291  ILE PHE THR GLN TYR
SEQRES   1 D  291  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES   2 D  291  LEU VAL PRO ARG GLY SER HIS MET LEU GLU GLN GLN GLY
SEQRES   3 D  291  LYS VAL TYR GLU THR ARG THR VAL LYS SER LYS ILE LEU
SEQRES   4 D  291  GLY MET GLU ARG SER TYR SER ILE TYR LEU PRO ALA GLY
SEQRES   5 D  291  TYR ASP GLU GLY ASP GLY SER TYR PRO VAL LEU TYR LEU
SEQRES   6 D  291  LEU HIS GLY LEU GLY ASP ASN HIS THR GLY TRP VAL GLN
SEQRES   7 D  291  PHE GLY GLN VAL GLN TYR ILE ALA ASP LYS ALA ILE ALA
SEQRES   8 D  291  GLU GLY LYS SER ALA PRO MET ILE ILE VAL MET PRO ASP
SEQRES   9 D  291  ALA ASP THR VAL HIS LYS GLY TYR PHE ASN LEU LEU ASP
SEQRES  10 D  291  GLY THR TYR ASN TYR GLU ASP PHE PHE PHE GLN GLU LEU
SEQRES  11 D  291  ILE PRO HIS ILE GLU LYS THR TYR ARG VAL ARG ALA GLU
SEQRES  12 D  291  SER ARG TYR ARG ALA ILE SER GLY LEU SER MET GLY GLY
SEQRES  13 D  291  GLY GLY ALA LEU PHE TYR ALA LEU HIS TYR PRO GLU MET
SEQRES  14 D  291  PHE VAL ALA VAL ALA PRO LEU SER ALA VAL GLY GLY ALA
SEQRES  15 D  291  TRP THR PHE ASP GLN MET LYS ASN GLN SER ASP LEU SER
SEQRES  16 D  291  LYS VAL SER GLU GLU LYS LYS ALA GLU VAL LEU GLY GLN
SEQRES  17 D  291  MET ASP ILE GLN THR ILE LEU GLU LYS SER PRO LYS GLU
SEQRES  18 D  291  LYS LEU ASP ARG ILE LYS TRP ILE ARG TRP TYR ILE SER
SEQRES  19 D  291  CYS GLY ASP ASP ASP PHE LEU SER VAL THR ASN CYS LEU
SEQRES  20 D  291  LEU HIS ASN THR LEU LEU GLN HIS GLN VAL GLY HIS GLU
SEQRES  21 D  291  PHE ARG MET LYS ASP GLY SER HIS SER TRP THR TYR TRP
SEQRES  22 D  291  ARG MET GLU LEU PRO GLU VAL MET ARG PHE VAL SER ARG
SEQRES  23 D  291  ILE PHE THR GLN TYR
SEQRES   1 E  291  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES   2 E  291  LEU VAL PRO ARG GLY SER HIS MET LEU GLU GLN GLN GLY
SEQRES   3 E  291  LYS VAL TYR GLU THR ARG THR VAL LYS SER LYS ILE LEU
SEQRES   4 E  291  GLY MET GLU ARG SER TYR SER ILE TYR LEU PRO ALA GLY
SEQRES   5 E  291  TYR ASP GLU GLY ASP GLY SER TYR PRO VAL LEU TYR LEU
SEQRES   6 E  291  LEU HIS GLY LEU GLY ASP ASN HIS THR GLY TRP VAL GLN
SEQRES   7 E  291  PHE GLY GLN VAL GLN TYR ILE ALA ASP LYS ALA ILE ALA
SEQRES   8 E  291  GLU GLY LYS SER ALA PRO MET ILE ILE VAL MET PRO ASP
SEQRES   9 E  291  ALA ASP THR VAL HIS LYS GLY TYR PHE ASN LEU LEU ASP
SEQRES  10 E  291  GLY THR TYR ASN TYR GLU ASP PHE PHE PHE GLN GLU LEU
SEQRES  11 E  291  ILE PRO HIS ILE GLU LYS THR TYR ARG VAL ARG ALA GLU
SEQRES  12 E  291  SER ARG TYR ARG ALA ILE SER GLY LEU SER MET GLY GLY
SEQRES  13 E  291  GLY GLY ALA LEU PHE TYR ALA LEU HIS TYR PRO GLU MET
SEQRES  14 E  291  PHE VAL ALA VAL ALA PRO LEU SER ALA VAL GLY GLY ALA
SEQRES  15 E  291  TRP THR PHE ASP GLN MET LYS ASN GLN SER ASP LEU SER
SEQRES  16 E  291  LYS VAL SER GLU GLU LYS LYS ALA GLU VAL LEU GLY GLN
SEQRES  17 E  291  MET ASP ILE GLN THR ILE LEU GLU LYS SER PRO LYS GLU
SEQRES  18 E  291  LYS LEU ASP ARG ILE LYS TRP ILE ARG TRP TYR ILE SER
SEQRES  19 E  291  CYS GLY ASP ASP ASP PHE LEU SER VAL THR ASN CYS LEU
SEQRES  20 E  291  LEU HIS ASN THR LEU LEU GLN HIS GLN VAL GLY HIS GLU
SEQRES  21 E  291  PHE ARG MET LYS ASP GLY SER HIS SER TRP THR TYR TRP
SEQRES  22 E  291  ARG MET GLU LEU PRO GLU VAL MET ARG PHE VAL SER ARG
SEQRES  23 E  291  ILE PHE THR GLN TYR
SEQRES   1 F  291  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES   2 F  291  LEU VAL PRO ARG GLY SER HIS MET LEU GLU GLN GLN GLY
SEQRES   3 F  291  LYS VAL TYR GLU THR ARG THR VAL LYS SER LYS ILE LEU
SEQRES   4 F  291  GLY MET GLU ARG SER TYR SER ILE TYR LEU PRO ALA GLY
SEQRES   5 F  291  TYR ASP GLU GLY ASP GLY SER TYR PRO VAL LEU TYR LEU
SEQRES   6 F  291  LEU HIS GLY LEU GLY ASP ASN HIS THR GLY TRP VAL GLN
SEQRES   7 F  291  PHE GLY GLN VAL GLN TYR ILE ALA ASP LYS ALA ILE ALA
SEQRES   8 F  291  GLU GLY LYS SER ALA PRO MET ILE ILE VAL MET PRO ASP
SEQRES   9 F  291  ALA ASP THR VAL HIS LYS GLY TYR PHE ASN LEU LEU ASP
SEQRES  10 F  291  GLY THR TYR ASN TYR GLU ASP PHE PHE PHE GLN GLU LEU
SEQRES  11 F  291  ILE PRO HIS ILE GLU LYS THR TYR ARG VAL ARG ALA GLU
SEQRES  12 F  291  SER ARG TYR ARG ALA ILE SER GLY LEU SER MET GLY GLY
SEQRES  13 F  291  GLY GLY ALA LEU PHE TYR ALA LEU HIS TYR PRO GLU MET
SEQRES  14 F  291  PHE VAL ALA VAL ALA PRO LEU SER ALA VAL GLY GLY ALA
SEQRES  15 F  291  TRP THR PHE ASP GLN MET LYS ASN GLN SER ASP LEU SER
SEQRES  16 F  291  LYS VAL SER GLU GLU LYS LYS ALA GLU VAL LEU GLY GLN
SEQRES  17 F  291  MET ASP ILE GLN THR ILE LEU GLU LYS SER PRO LYS GLU
SEQRES  18 F  291  LYS LEU ASP ARG ILE LYS TRP ILE ARG TRP TYR ILE SER
SEQRES  19 F  291  CYS GLY ASP ASP ASP PHE LEU SER VAL THR ASN CYS LEU
SEQRES  20 F  291  LEU HIS ASN THR LEU LEU GLN HIS GLN VAL GLY HIS GLU
SEQRES  21 F  291  PHE ARG MET LYS ASP GLY SER HIS SER TRP THR TYR TRP
SEQRES  22 F  291  ARG MET GLU LEU PRO GLU VAL MET ARG PHE VAL SER ARG
SEQRES  23 F  291  ILE PHE THR GLN TYR
SEQRES   1 G  291  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES   2 G  291  LEU VAL PRO ARG GLY SER HIS MET LEU GLU GLN GLN GLY
SEQRES   3 G  291  LYS VAL TYR GLU THR ARG THR VAL LYS SER LYS ILE LEU
SEQRES   4 G  291  GLY MET GLU ARG SER TYR SER ILE TYR LEU PRO ALA GLY
SEQRES   5 G  291  TYR ASP GLU GLY ASP GLY SER TYR PRO VAL LEU TYR LEU
SEQRES   6 G  291  LEU HIS GLY LEU GLY ASP ASN HIS THR GLY TRP VAL GLN
SEQRES   7 G  291  PHE GLY GLN VAL GLN TYR ILE ALA ASP LYS ALA ILE ALA
SEQRES   8 G  291  GLU GLY LYS SER ALA PRO MET ILE ILE VAL MET PRO ASP
SEQRES   9 G  291  ALA ASP THR VAL HIS LYS GLY TYR PHE ASN LEU LEU ASP
SEQRES  10 G  291  GLY THR TYR ASN TYR GLU ASP PHE PHE PHE GLN GLU LEU
SEQRES  11 G  291  ILE PRO HIS ILE GLU LYS THR TYR ARG VAL ARG ALA GLU
SEQRES  12 G  291  SER ARG TYR ARG ALA ILE SER GLY LEU SER MET GLY GLY
SEQRES  13 G  291  GLY GLY ALA LEU PHE TYR ALA LEU HIS TYR PRO GLU MET
SEQRES  14 G  291  PHE VAL ALA VAL ALA PRO LEU SER ALA VAL GLY GLY ALA
SEQRES  15 G  291  TRP THR PHE ASP GLN MET LYS ASN GLN SER ASP LEU SER
SEQRES  16 G  291  LYS VAL SER GLU GLU LYS LYS ALA GLU VAL LEU GLY GLN
SEQRES  17 G  291  MET ASP ILE GLN THR ILE LEU GLU LYS SER PRO LYS GLU
SEQRES  18 G  291  LYS LEU ASP ARG ILE LYS TRP ILE ARG TRP TYR ILE SER
SEQRES  19 G  291  CYS GLY ASP ASP ASP PHE LEU SER VAL THR ASN CYS LEU
SEQRES  20 G  291  LEU HIS ASN THR LEU LEU GLN HIS GLN VAL GLY HIS GLU
SEQRES  21 G  291  PHE ARG MET LYS ASP GLY SER HIS SER TRP THR TYR TRP
SEQRES  22 G  291  ARG MET GLU LEU PRO GLU VAL MET ARG PHE VAL SER ARG
SEQRES  23 G  291  ILE PHE THR GLN TYR
SEQRES   1 H  291  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES   2 H  291  LEU VAL PRO ARG GLY SER HIS MET LEU GLU GLN GLN GLY
SEQRES   3 H  291  LYS VAL TYR GLU THR ARG THR VAL LYS SER LYS ILE LEU
SEQRES   4 H  291  GLY MET GLU ARG SER TYR SER ILE TYR LEU PRO ALA GLY
SEQRES   5 H  291  TYR ASP GLU GLY ASP GLY SER TYR PRO VAL LEU TYR LEU
SEQRES   6 H  291  LEU HIS GLY LEU GLY ASP ASN HIS THR GLY TRP VAL GLN
SEQRES   7 H  291  PHE GLY GLN VAL GLN TYR ILE ALA ASP LYS ALA ILE ALA
SEQRES   8 H  291  GLU GLY LYS SER ALA PRO MET ILE ILE VAL MET PRO ASP
SEQRES   9 H  291  ALA ASP THR VAL HIS LYS GLY TYR PHE ASN LEU LEU ASP
SEQRES  10 H  291  GLY THR TYR ASN TYR GLU ASP PHE PHE PHE GLN GLU LEU
SEQRES  11 H  291  ILE PRO HIS ILE GLU LYS THR TYR ARG VAL ARG ALA GLU
SEQRES  12 H  291  SER ARG TYR ARG ALA ILE SER GLY LEU SER MET GLY GLY
SEQRES  13 H  291  GLY GLY ALA LEU PHE TYR ALA LEU HIS TYR PRO GLU MET
SEQRES  14 H  291  PHE VAL ALA VAL ALA PRO LEU SER ALA VAL GLY GLY ALA
SEQRES  15 H  291  TRP THR PHE ASP GLN MET LYS ASN GLN SER ASP LEU SER
SEQRES  16 H  291  LYS VAL SER GLU GLU LYS LYS ALA GLU VAL LEU GLY GLN
SEQRES  17 H  291  MET ASP ILE GLN THR ILE LEU GLU LYS SER PRO LYS GLU
SEQRES  18 H  291  LYS LEU ASP ARG ILE LYS TRP ILE ARG TRP TYR ILE SER
SEQRES  19 H  291  CYS GLY ASP ASP ASP PHE LEU SER VAL THR ASN CYS LEU
SEQRES  20 H  291  LEU HIS ASN THR LEU LEU GLN HIS GLN VAL GLY HIS GLU
SEQRES  21 H  291  PHE ARG MET LYS ASP GLY SER HIS SER TRP THR TYR TRP
SEQRES  22 H  291  ARG MET GLU LEU PRO GLU VAL MET ARG PHE VAL SER ARG
SEQRES  23 H  291  ILE PHE THR GLN TYR
SEQRES   1 I  291  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES   2 I  291  LEU VAL PRO ARG GLY SER HIS MET LEU GLU GLN GLN GLY
SEQRES   3 I  291  LYS VAL TYR GLU THR ARG THR VAL LYS SER LYS ILE LEU
SEQRES   4 I  291  GLY MET GLU ARG SER TYR SER ILE TYR LEU PRO ALA GLY
SEQRES   5 I  291  TYR ASP GLU GLY ASP GLY SER TYR PRO VAL LEU TYR LEU
SEQRES   6 I  291  LEU HIS GLY LEU GLY ASP ASN HIS THR GLY TRP VAL GLN
SEQRES   7 I  291  PHE GLY GLN VAL GLN TYR ILE ALA ASP LYS ALA ILE ALA
SEQRES   8 I  291  GLU GLY LYS SER ALA PRO MET ILE ILE VAL MET PRO ASP
SEQRES   9 I  291  ALA ASP THR VAL HIS LYS GLY TYR PHE ASN LEU LEU ASP
SEQRES  10 I  291  GLY THR TYR ASN TYR GLU ASP PHE PHE PHE GLN GLU LEU
SEQRES  11 I  291  ILE PRO HIS ILE GLU LYS THR TYR ARG VAL ARG ALA GLU
SEQRES  12 I  291  SER ARG TYR ARG ALA ILE SER GLY LEU SER MET GLY GLY
SEQRES  13 I  291  GLY GLY ALA LEU PHE TYR ALA LEU HIS TYR PRO GLU MET
SEQRES  14 I  291  PHE VAL ALA VAL ALA PRO LEU SER ALA VAL GLY GLY ALA
SEQRES  15 I  291  TRP THR PHE ASP GLN MET LYS ASN GLN SER ASP LEU SER
SEQRES  16 I  291  LYS VAL SER GLU GLU LYS LYS ALA GLU VAL LEU GLY GLN
SEQRES  17 I  291  MET ASP ILE GLN THR ILE LEU GLU LYS SER PRO LYS GLU
SEQRES  18 I  291  LYS LEU ASP ARG ILE LYS TRP ILE ARG TRP TYR ILE SER
SEQRES  19 I  291  CYS GLY ASP ASP ASP PHE LEU SER VAL THR ASN CYS LEU
SEQRES  20 I  291  LEU HIS ASN THR LEU LEU GLN HIS GLN VAL GLY HIS GLU
SEQRES  21 I  291  PHE ARG MET LYS ASP GLY SER HIS SER TRP THR TYR TRP
SEQRES  22 I  291  ARG MET GLU LEU PRO GLU VAL MET ARG PHE VAL SER ARG
SEQRES  23 I  291  ILE PHE THR GLN TYR
SEQRES   1 J  291  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES   2 J  291  LEU VAL PRO ARG GLY SER HIS MET LEU GLU GLN GLN GLY
SEQRES   3 J  291  LYS VAL TYR GLU THR ARG THR VAL LYS SER LYS ILE LEU
SEQRES   4 J  291  GLY MET GLU ARG SER TYR SER ILE TYR LEU PRO ALA GLY
SEQRES   5 J  291  TYR ASP GLU GLY ASP GLY SER TYR PRO VAL LEU TYR LEU
SEQRES   6 J  291  LEU HIS GLY LEU GLY ASP ASN HIS THR GLY TRP VAL GLN
SEQRES   7 J  291  PHE GLY GLN VAL GLN TYR ILE ALA ASP LYS ALA ILE ALA
SEQRES   8 J  291  GLU GLY LYS SER ALA PRO MET ILE ILE VAL MET PRO ASP
SEQRES   9 J  291  ALA ASP THR VAL HIS LYS GLY TYR PHE ASN LEU LEU ASP
SEQRES  10 J  291  GLY THR TYR ASN TYR GLU ASP PHE PHE PHE GLN GLU LEU
SEQRES  11 J  291  ILE PRO HIS ILE GLU LYS THR TYR ARG VAL ARG ALA GLU
SEQRES  12 J  291  SER ARG TYR ARG ALA ILE SER GLY LEU SER MET GLY GLY
SEQRES  13 J  291  GLY GLY ALA LEU PHE TYR ALA LEU HIS TYR PRO GLU MET
SEQRES  14 J  291  PHE VAL ALA VAL ALA PRO LEU SER ALA VAL GLY GLY ALA
SEQRES  15 J  291  TRP THR PHE ASP GLN MET LYS ASN GLN SER ASP LEU SER
SEQRES  16 J  291  LYS VAL SER GLU GLU LYS LYS ALA GLU VAL LEU GLY GLN
SEQRES  17 J  291  MET ASP ILE GLN THR ILE LEU GLU LYS SER PRO LYS GLU
SEQRES  18 J  291  LYS LEU ASP ARG ILE LYS TRP ILE ARG TRP TYR ILE SER
SEQRES  19 J  291  CYS GLY ASP ASP ASP PHE LEU SER VAL THR ASN CYS LEU
SEQRES  20 J  291  LEU HIS ASN THR LEU LEU GLN HIS GLN VAL GLY HIS GLU
SEQRES  21 J  291  PHE ARG MET LYS ASP GLY SER HIS SER TRP THR TYR TRP
SEQRES  22 J  291  ARG MET GLU LEU PRO GLU VAL MET ARG PHE VAL SER ARG
SEQRES  23 J  291  ILE PHE THR GLN TYR
HET     CA  A 301       1
HET    MPD  A 302       8
HET     CA  B 301       1
HET     CA  C 301       1
HET     CA  D 301       1
HET    MPD  D 302       8
HET     CA  E 301       1
HET    MPD  E 302       8
HET     CA  F 301       1
HET    MPD  F 302       8
HET     CA  G 301       1
HET    MPD  G 302       8
HET    MPD  G 303       8
HET     CA  H 301       1
HET    MPD  H 302       8
HET     CA  I 301       1
HET    MPD  I 302       8
HET     CA  J 301       1
HET    MPD  J 302       8
HETNAM      CA CALCIUM ION
HETNAM     MPD (4S)-2-METHYL-2,4-PENTANEDIOL
FORMUL  11   CA    10(CA 2+)
FORMUL  12  MPD    9(C6 H14 O2)
FORMUL  30  HOH   *1881(H2 O)
HELIX    1 AA1 THR A   71  PHE A   76  1                                   6
HELIX    2 AA2 GLN A   78  GLU A   89  1                                  12
HELIX    3 AA3 ASN A  118  GLU A  126  1                                   9
HELIX    4 AA4 GLU A  126  TYR A  135  1                                  10
HELIX    5 AA5 GLU A  140  ARG A  142  5                                   3
HELIX    6 AA6 SER A  150  TYR A  163  1                                  14
HELIX    7 AA7 PRO A  164  PHE A  167  5                                   4
HELIX    8 AA8 GLY A  177  GLN A  188  1                                  12
HELIX    9 AA9 ASP A  190  VAL A  194  5                                   5
HELIX   10 AB1 SER A  195  MET A  206  1                                  12
HELIX   11 AB2 ASP A  207  SER A  215  1                                   9
HELIX   12 AB3 PRO A  216  ILE A  226  1                                  11
HELIX   13 AB4 LEU A  238  HIS A  252  1                                  15
HELIX   14 AB5 SER A  266  GLN A  287  1                                  22
HELIX   15 AB6 THR B   71  PHE B   76  1                                   6
HELIX   16 AB7 GLN B   78  GLU B   89  1                                  12
HELIX   17 AB8 ASN B  118  GLU B  126  1                                   9
HELIX   18 AB9 GLU B  126  TYR B  135  1                                  10
HELIX   19 AC1 GLU B  140  ARG B  142  5                                   3
HELIX   20 AC2 SER B  150  TYR B  163  1                                  14
HELIX   21 AC3 PRO B  164  PHE B  167  5                                   4
HELIX   22 AC4 GLY B  177  ASN B  187  1                                  11
HELIX   23 AC5 GLN B  188  SER B  189  5                                   2
HELIX   24 AC6 ASP B  190  VAL B  194  5                                   5
HELIX   25 AC7 SER B  195  MET B  206  1                                  12
HELIX   26 AC8 ASP B  207  SER B  215  1                                   9
HELIX   27 AC9 PRO B  216  ILE B  226  1                                  11
HELIX   28 AD1 LEU B  238  HIS B  252  1                                  15
HELIX   29 AD2 SER B  266  GLN B  287  1                                  22
HELIX   30 AD3 THR C   71  PHE C   76  1                                   6
HELIX   31 AD4 GLN C   78  GLU C   89  1                                  12
HELIX   32 AD5 ASN C  118  GLU C  126  1                                   9
HELIX   33 AD6 GLU C  126  TYR C  135  1                                  10
HELIX   34 AD7 GLU C  140  ARG C  142  5                                   3
HELIX   35 AD8 SER C  150  TYR C  163  1                                  14
HELIX   36 AD9 PRO C  164  PHE C  167  5                                   4
HELIX   37 AE1 GLY C  177  SER C  189  1                                  13
HELIX   38 AE2 ASP C  190  VAL C  194  5                                   5
HELIX   39 AE3 SER C  195  MET C  206  1                                  12
HELIX   40 AE4 ASP C  207  SER C  215  1                                   9
HELIX   41 AE5 PRO C  216  ILE C  226  1                                  11
HELIX   42 AE6 LEU C  238  HIS C  252  1                                  15
HELIX   43 AE7 SER C  266  GLN C  287  1                                  22
HELIX   44 AE8 THR D   71  PHE D   76  1                                   6
HELIX   45 AE9 GLN D   78  GLU D   89  1                                  12
HELIX   46 AF1 ASN D  118  GLU D  126  1                                   9
HELIX   47 AF2 GLU D  126  TYR D  135  1                                  10
HELIX   48 AF3 GLU D  140  ARG D  142  5                                   3
HELIX   49 AF4 SER D  150  TYR D  163  1                                  14
HELIX   50 AF5 PRO D  164  PHE D  167  5                                   4
HELIX   51 AF6 GLY D  177  SER D  189  1                                  13
HELIX   52 AF7 ASP D  190  VAL D  194  5                                   5
HELIX   53 AF8 SER D  195  MET D  206  1                                  12
HELIX   54 AF9 ASP D  207  SER D  215  1                                   9
HELIX   55 AG1 PRO D  216  ILE D  226  1                                  11
HELIX   56 AG2 LEU D  238  HIS D  252  1                                  15
HELIX   57 AG3 SER D  266  GLN D  287  1                                  22
HELIX   58 AG4 THR E   71  PHE E   76  1                                   6
HELIX   59 AG5 GLN E   78  GLU E   89  1                                  12
HELIX   60 AG6 ASN E  118  GLU E  126  1                                   9
HELIX   61 AG7 GLU E  126  TYR E  135  1                                  10
HELIX   62 AG8 GLU E  140  ARG E  142  5                                   3
HELIX   63 AG9 SER E  150  TYR E  163  1                                  14
HELIX   64 AH1 PRO E  164  PHE E  167  5                                   4
HELIX   65 AH2 GLY E  177  GLN E  188  1                                  12
HELIX   66 AH3 ASP E  190  VAL E  194  5                                   5
HELIX   67 AH4 SER E  195  MET E  206  1                                  12
HELIX   68 AH5 ASP E  207  SER E  215  1                                   9
HELIX   69 AH6 PRO E  216  ILE E  226  1                                  11
HELIX   70 AH7 LEU E  238  HIS E  252  1                                  15
HELIX   71 AH8 SER E  266  GLN E  287  1                                  22
HELIX   72 AH9 THR F   71  PHE F   76  1                                   6
HELIX   73 AI1 GLN F   78  GLU F   89  1                                  12
HELIX   74 AI2 ASN F  118  GLU F  126  1                                   9
HELIX   75 AI3 GLU F  126  TYR F  135  1                                  10
HELIX   76 AI4 GLU F  140  ARG F  142  5                                   3
HELIX   77 AI5 SER F  150  TYR F  163  1                                  14
HELIX   78 AI6 PRO F  164  PHE F  167  5                                   4
HELIX   79 AI7 GLY F  177  ASN F  187  1                                  11
HELIX   80 AI8 GLN F  188  SER F  189  5                                   2
HELIX   81 AI9 ASP F  190  VAL F  194  5                                   5
HELIX   82 AJ1 SER F  195  MET F  206  1                                  12
HELIX   83 AJ2 ASP F  207  SER F  215  1                                   9
HELIX   84 AJ3 PRO F  216  ILE F  226  1                                  11
HELIX   85 AJ4 LEU F  238  HIS F  252  1                                  15
HELIX   86 AJ5 SER F  266  GLN F  287  1                                  22
HELIX   87 AJ6 THR G   71  PHE G   76  1                                   6
HELIX   88 AJ7 GLN G   78  GLU G   89  1                                  12
HELIX   89 AJ8 ASN G  118  GLU G  126  1                                   9
HELIX   90 AJ9 GLU G  126  TYR G  135  1                                  10
HELIX   91 AK1 GLU G  140  ARG G  142  5                                   3
HELIX   92 AK2 SER G  150  TYR G  163  1                                  14
HELIX   93 AK3 PRO G  164  PHE G  167  5                                   4
HELIX   94 AK4 GLY G  177  SER G  189  1                                  13
HELIX   95 AK5 ASP G  190  VAL G  194  5                                   5
HELIX   96 AK6 SER G  195  MET G  206  1                                  12
HELIX   97 AK7 ASP G  207  SER G  215  1                                   9
HELIX   98 AK8 PRO G  216  ILE G  226  1                                  11
HELIX   99 AK9 LEU G  238  HIS G  252  1                                  15
HELIX  100 AL1 SER G  266  GLN G  287  1                                  22
HELIX  101 AL2 THR H   71  PHE H   76  1                                   6
HELIX  102 AL3 GLN H   78  GLU H   89  1                                  12
HELIX  103 AL4 ASN H  118  GLU H  126  1                                   9
HELIX  104 AL5 GLU H  126  TYR H  135  1                                  10
HELIX  105 AL6 GLU H  140  ARG H  142  5                                   3
HELIX  106 AL7 SER H  150  TYR H  163  1                                  14
HELIX  107 AL8 PRO H  164  PHE H  167  5                                   4
HELIX  108 AL9 GLY H  177  GLN H  188  1                                  12
HELIX  109 AM1 ASP H  190  VAL H  194  5                                   5
HELIX  110 AM2 SER H  195  MET H  206  1                                  12
HELIX  111 AM3 ASP H  207  SER H  215  1                                   9
HELIX  112 AM4 PRO H  216  ILE H  226  1                                  11
HELIX  113 AM5 LEU H  238  HIS H  252  1                                  15
HELIX  114 AM6 SER H  266  GLN H  287  1                                  22
HELIX  115 AM7 THR I   71  PHE I   76  1                                   6
HELIX  116 AM8 GLN I   78  GLU I   89  1                                  12
HELIX  117 AM9 ASN I  118  GLU I  126  1                                   9
HELIX  118 AN1 GLU I  126  TYR I  135  1                                  10
HELIX  119 AN2 GLU I  140  ARG I  142  5                                   3
HELIX  120 AN3 SER I  150  TYR I  163  1                                  14
HELIX  121 AN4 PRO I  164  PHE I  167  5                                   4
HELIX  122 AN5 GLY I  177  GLN I  188  1                                  12
HELIX  123 AN6 ASP I  190  VAL I  194  5                                   5
HELIX  124 AN7 SER I  195  MET I  206  1                                  12
HELIX  125 AN8 ASP I  207  SER I  215  1                                   9
HELIX  126 AN9 PRO I  216  ILE I  226  1                                  11
HELIX  127 AO1 LEU I  238  HIS I  252  1                                  15
HELIX  128 AO2 SER I  266  GLN I  287  1                                  22
HELIX  129 AO3 THR J   71  PHE J   76  1                                   6
HELIX  130 AO4 GLN J   78  GLU J   89  1                                  12
HELIX  131 AO5 ASN J  118  GLU J  126  1                                   9
HELIX  132 AO6 GLU J  126  TYR J  135  1                                  10
HELIX  133 AO7 GLU J  140  ARG J  142  5                                   3
HELIX  134 AO8 SER J  150  TYR J  163  1                                  14
HELIX  135 AO9 PRO J  164  PHE J  167  5                                   4
HELIX  136 AP1 GLY J  177  GLN J  188  1                                  12
HELIX  137 AP2 ASP J  190  VAL J  194  5                                   5
HELIX  138 AP3 SER J  195  MET J  206  1                                  12
HELIX  139 AP4 ASP J  207  SER J  215  1                                   9
HELIX  140 AP5 PRO J  216  ILE J  226  1                                  11
HELIX  141 AP6 LEU J  238  HIS J  252  1                                  15
HELIX  142 AP7 SER J  266  GLN J  287  1                                  22
SHEET    1 AA1 3 LYS A  24  TYR A  26  0
SHEET    2 AA1 3 MET A  38  LEU A  46 -1  O  LEU A  46   N  LYS A  24
SHEET    3 AA1 3 THR A  30  SER A  33 -1  N  VAL A  31   O  ARG A  40
SHEET    1 AA2 8 LYS A  24  TYR A  26  0
SHEET    2 AA2 8 MET A  38  LEU A  46 -1  O  LEU A  46   N  LYS A  24
SHEET    3 AA2 8 ILE A  96  PRO A 100 -1  O  MET A  99   N  SER A  43
SHEET    4 AA2 8 VAL A  59  LEU A  63  1  N  LEU A  62   O  VAL A  98
SHEET    5 AA2 8 ARG A 144  LEU A 149  1  O  ALA A 145   N  TYR A  61
SHEET    6 AA2 8 ALA A 169  LEU A 173  1  O  LEU A 173   N  GLY A 148
SHEET    7 AA2 8 ARG A 227  GLY A 233  1  O  TYR A 229   N  VAL A 170
SHEET    8 AA2 8 GLU A 257  LYS A 261  1  O  GLU A 257   N  TRP A 228
SHEET    1 AA3 3 LYS B  24  TYR B  26  0
SHEET    2 AA3 3 MET B  38  LEU B  46 -1  O  LEU B  46   N  LYS B  24
SHEET    3 AA3 3 THR B  30  SER B  33 -1  N  VAL B  31   O  ARG B  40
SHEET    1 AA4 8 LYS B  24  TYR B  26  0
SHEET    2 AA4 8 MET B  38  LEU B  46 -1  O  LEU B  46   N  LYS B  24
SHEET    3 AA4 8 ILE B  96  PRO B 100 -1  O  MET B  99   N  SER B  43
SHEET    4 AA4 8 VAL B  59  LEU B  63  1  N  LEU B  62   O  VAL B  98
SHEET    5 AA4 8 ARG B 144  LEU B 149  1  O  SER B 147   N  TYR B  61
SHEET    6 AA4 8 ALA B 169  LEU B 173  1  O  LEU B 173   N  GLY B 148
SHEET    7 AA4 8 ARG B 227  GLY B 233  1  O  TYR B 229   N  VAL B 170
SHEET    8 AA4 8 GLU B 257  LYS B 261  1  O  ARG B 259   N  ILE B 230
SHEET    1 AA5 3 LYS C  24  TYR C  26  0
SHEET    2 AA5 3 MET C  38  LEU C  46 -1  O  LEU C  46   N  LYS C  24
SHEET    3 AA5 3 THR C  30  SER C  33 -1  N  VAL C  31   O  ARG C  40
SHEET    1 AA6 8 LYS C  24  TYR C  26  0
SHEET    2 AA6 8 MET C  38  LEU C  46 -1  O  LEU C  46   N  LYS C  24
SHEET    3 AA6 8 ILE C  96  PRO C 100 -1  O  MET C  99   N  SER C  43
SHEET    4 AA6 8 VAL C  59  LEU C  63  1  N  LEU C  62   O  VAL C  98
SHEET    5 AA6 8 ARG C 144  LEU C 149  1  O  SER C 147   N  TYR C  61
SHEET    6 AA6 8 ALA C 169  LEU C 173  1  O  LEU C 173   N  GLY C 148
SHEET    7 AA6 8 ARG C 227  GLY C 233  1  O  TYR C 229   N  VAL C 170
SHEET    8 AA6 8 GLU C 257  LYS C 261  1  O  GLU C 257   N  ILE C 230
SHEET    1 AA7 3 LYS D  24  TYR D  26  0
SHEET    2 AA7 3 MET D  38  LEU D  46 -1  O  LEU D  46   N  LYS D  24
SHEET    3 AA7 3 THR D  30  SER D  33 -1  N  VAL D  31   O  ARG D  40
SHEET    1 AA8 8 LYS D  24  TYR D  26  0
SHEET    2 AA8 8 MET D  38  LEU D  46 -1  O  LEU D  46   N  LYS D  24
SHEET    3 AA8 8 ILE D  96  PRO D 100 -1  O  MET D  99   N  SER D  43
SHEET    4 AA8 8 VAL D  59  LEU D  63  1  N  LEU D  60   O  ILE D  96
SHEET    5 AA8 8 ARG D 144  LEU D 149  1  O  SER D 147   N  TYR D  61
SHEET    6 AA8 8 ALA D 169  LEU D 173  1  O  LEU D 173   N  GLY D 148
SHEET    7 AA8 8 ARG D 227  GLY D 233  1  O  TYR D 229   N  VAL D 170
SHEET    8 AA8 8 GLU D 257  LYS D 261  1  O  GLU D 257   N  ILE D 230
SHEET    1 AA9 3 LYS E  24  TYR E  26  0
SHEET    2 AA9 3 MET E  38  LEU E  46 -1  O  LEU E  46   N  LYS E  24
SHEET    3 AA9 3 THR E  30  SER E  33 -1  N  SER E  33   O  MET E  38
SHEET    1 AB1 8 LYS E  24  TYR E  26  0
SHEET    2 AB1 8 MET E  38  LEU E  46 -1  O  LEU E  46   N  LYS E  24
SHEET    3 AB1 8 ILE E  96  PRO E 100 -1  O  MET E  99   N  SER E  43
SHEET    4 AB1 8 VAL E  59  LEU E  63  1  N  LEU E  62   O  VAL E  98
SHEET    5 AB1 8 ARG E 144  LEU E 149  1  O  SER E 147   N  TYR E  61
SHEET    6 AB1 8 ALA E 169  LEU E 173  1  O  LEU E 173   N  GLY E 148
SHEET    7 AB1 8 ARG E 227  GLY E 233  1  O  TYR E 229   N  VAL E 170
SHEET    8 AB1 8 GLU E 257  LYS E 261  1  O  GLU E 257   N  TRP E 228
SHEET    1 AB2 3 LYS F  24  TYR F  26  0
SHEET    2 AB2 3 MET F  38  LEU F  46 -1  O  LEU F  46   N  LYS F  24
SHEET    3 AB2 3 THR F  30  SER F  33 -1  N  VAL F  31   O  ARG F  40
SHEET    1 AB3 8 LYS F  24  TYR F  26  0
SHEET    2 AB3 8 MET F  38  LEU F  46 -1  O  LEU F  46   N  LYS F  24
SHEET    3 AB3 8 ILE F  96  PRO F 100 -1  O  MET F  99   N  SER F  43
SHEET    4 AB3 8 VAL F  59  LEU F  63  1  N  LEU F  62   O  VAL F  98
SHEET    5 AB3 8 ARG F 144  LEU F 149  1  O  SER F 147   N  TYR F  61
SHEET    6 AB3 8 ALA F 169  LEU F 173  1  O  LEU F 173   N  GLY F 148
SHEET    7 AB3 8 ARG F 227  GLY F 233  1  O  TYR F 229   N  VAL F 170
SHEET    8 AB3 8 GLU F 257  LYS F 261  1  O  ARG F 259   N  ILE F 230
SHEET    1 AB4 3 LYS G  24  TYR G  26  0
SHEET    2 AB4 3 MET G  38  LEU G  46 -1  O  LEU G  46   N  LYS G  24
SHEET    3 AB4 3 THR G  30  SER G  33 -1  N  SER G  33   O  MET G  38
SHEET    1 AB5 8 LYS G  24  TYR G  26  0
SHEET    2 AB5 8 MET G  38  LEU G  46 -1  O  LEU G  46   N  LYS G  24
SHEET    3 AB5 8 ILE G  96  PRO G 100 -1  O  MET G  99   N  SER G  43
SHEET    4 AB5 8 VAL G  59  LEU G  63  1  N  LEU G  62   O  VAL G  98
SHEET    5 AB5 8 ARG G 144  LEU G 149  1  O  SER G 147   N  TYR G  61
SHEET    6 AB5 8 ALA G 169  LEU G 173  1  O  LEU G 173   N  GLY G 148
SHEET    7 AB5 8 ARG G 227  GLY G 233  1  O  TYR G 229   N  VAL G 170
SHEET    8 AB5 8 GLU G 257  LYS G 261  1  O  GLU G 257   N  ILE G 230
SHEET    1 AB6 3 LYS H  24  TYR H  26  0
SHEET    2 AB6 3 MET H  38  LEU H  46 -1  O  LEU H  46   N  LYS H  24
SHEET    3 AB6 3 THR H  30  SER H  33 -1  N  VAL H  31   O  ARG H  40
SHEET    1 AB7 8 LYS H  24  TYR H  26  0
SHEET    2 AB7 8 MET H  38  LEU H  46 -1  O  LEU H  46   N  LYS H  24
SHEET    3 AB7 8 ILE H  96  PRO H 100 -1  O  MET H  99   N  SER H  43
SHEET    4 AB7 8 VAL H  59  LEU H  63  1  N  LEU H  62   O  VAL H  98
SHEET    5 AB7 8 ARG H 144  LEU H 149  1  O  ALA H 145   N  TYR H  61
SHEET    6 AB7 8 ALA H 169  LEU H 173  1  O  LEU H 173   N  GLY H 148
SHEET    7 AB7 8 ARG H 227  GLY H 233  1  O  TYR H 229   N  VAL H 170
SHEET    8 AB7 8 GLU H 257  LYS H 261  1  O  GLU H 257   N  TRP H 228
SHEET    1 AB8 3 LYS I  24  TYR I  26  0
SHEET    2 AB8 3 MET I  38  LEU I  46 -1  O  LEU I  46   N  LYS I  24
SHEET    3 AB8 3 THR I  30  SER I  33 -1  N  VAL I  31   O  ARG I  40
SHEET    1 AB9 8 LYS I  24  TYR I  26  0
SHEET    2 AB9 8 MET I  38  LEU I  46 -1  O  LEU I  46   N  LYS I  24
SHEET    3 AB9 8 ILE I  96  PRO I 100 -1  O  MET I  99   N  SER I  43
SHEET    4 AB9 8 VAL I  59  LEU I  63  1  N  LEU I  62   O  VAL I  98
SHEET    5 AB9 8 ARG I 144  LEU I 149  1  O  ALA I 145   N  TYR I  61
SHEET    6 AB9 8 ALA I 169  LEU I 173  1  O  LEU I 173   N  GLY I 148
SHEET    7 AB9 8 ARG I 227  GLY I 233  1  O  TYR I 229   N  VAL I 170
SHEET    8 AB9 8 GLU I 257  LYS I 261  1  O  GLU I 257   N  TRP I 228
SHEET    1 AC1 3 LYS J  24  TYR J  26  0
SHEET    2 AC1 3 MET J  38  LEU J  46 -1  O  LEU J  46   N  LYS J  24
SHEET    3 AC1 3 THR J  30  SER J  33 -1  N  VAL J  31   O  ARG J  40
SHEET    1 AC2 8 LYS J  24  TYR J  26  0
SHEET    2 AC2 8 MET J  38  LEU J  46 -1  O  LEU J  46   N  LYS J  24
SHEET    3 AC2 8 ILE J  96  PRO J 100 -1  O  MET J  99   N  SER J  43
SHEET    4 AC2 8 VAL J  59  LEU J  63  1  N  LEU J  62   O  VAL J  98
SHEET    5 AC2 8 ARG J 144  LEU J 149  1  O  SER J 147   N  TYR J  61
SHEET    6 AC2 8 ALA J 169  LEU J 173  1  O  LEU J 173   N  GLY J 148
SHEET    7 AC2 8 ARG J 227  GLY J 233  1  O  TYR J 229   N  VAL J 170
SHEET    8 AC2 8 GLU J 257  LYS J 261  1  O  GLU J 257   N  TRP J 228
LINK         OD1 ASP A 234                CA    CA A 301     1555   1555  2.71
LINK         OD2 ASP A 234                CA    CA A 301     1555   1555  2.68
LINK         OD1 ASP A 235                CA    CA A 301     1555   1555  2.66
LINK         OD2 ASP A 235                CA    CA A 301     1555   1555  2.56
LINK         OE2 GLU A 257                CA    CA B 301     1555   1555  2.62
LINK         OD1 ASP A 262                CA    CA A 301     1555   1555  2.25
LINK        CA    CA A 301                 OE2 GLU B 257     1555   1555  2.57
LINK         OD1 ASP B 234                CA    CA B 301     1555   1555  2.64
LINK         OD2 ASP B 234                CA    CA B 301     1555   1555  2.54
LINK         OD1 ASP B 235                CA    CA B 301     1555   1555  2.56
LINK         OD2 ASP B 235                CA    CA B 301     1555   1555  2.64
LINK         OD1 ASP B 262                CA    CA B 301     1555   1555  2.32
LINK         OD1 ASP C 234                CA    CA C 301     1555   1555  2.65
LINK         OD2 ASP C 234                CA    CA C 301     1555   1555  2.69
LINK         OD1 ASP C 235                CA    CA C 301     1555   1555  2.59
LINK         OD2 ASP C 235                CA    CA C 301     1555   1555  2.55
LINK         OE1 GLU C 257                CA    CA E 301     1555   1555  2.54
LINK         OD1 ASP C 262                CA    CA C 301     1555   1555  2.38
LINK        CA    CA C 301                 OE2 GLU E 257     1555   1555  2.46
LINK         OD1 ASP D 234                CA    CA D 301     1555   1555  2.67
LINK         OD2 ASP D 234                CA    CA D 301     1555   1555  2.54
LINK         OD1 ASP D 235                CA    CA D 301     1555   1555  2.67
LINK         OD2 ASP D 235                CA    CA D 301     1555   1555  2.35
LINK         OE2 GLU D 257                CA    CA G 301     1555   1555  2.58
LINK         OD1 ASP D 262                CA    CA D 301     1555   1555  2.42
LINK        CA    CA D 301                 OE2 GLU G 257     1555   1555  2.44
LINK         OD1 ASP E 234                CA    CA E 301     1555   1555  2.63
LINK         OD2 ASP E 234                CA    CA E 301     1555   1555  2.65
LINK         OD1 ASP E 235                CA    CA E 301     1555   1555  2.77
LINK         OD2 ASP E 235                CA    CA E 301     1555   1555  2.58
LINK         OD1 ASP E 262                CA    CA E 301     1555   1555  2.36
LINK         OD1 ASP F 234                CA    CA F 301     1555   1555  2.68
LINK         OD2 ASP F 234                CA    CA F 301     1555   1555  2.66
LINK         OD1 ASP F 235                CA    CA F 301     1555   1555  2.59
LINK         OD2 ASP F 235                CA    CA F 301     1555   1555  2.53
LINK         OE2 GLU F 257                CA    CA H 301     1555   1555  2.55
LINK         OD1 ASP F 262                CA    CA F 301     1555   1555  2.47
LINK        CA    CA F 301                 OE2 GLU H 257     1555   1555  2.49
LINK         OD1 ASP G 234                CA    CA G 301     1555   1555  2.65
LINK         OD2 ASP G 234                CA    CA G 301     1555   1555  2.69
LINK         OD1 ASP G 235                CA    CA G 301     1555   1555  2.65
LINK         OD2 ASP G 235                CA    CA G 301     1555   1555  2.44
LINK         OD1 ASP G 262                CA    CA G 301     1555   1555  2.44
LINK         OD1 ASP H 234                CA    CA H 301     1555   1555  2.67
LINK         OD2 ASP H 234                CA    CA H 301     1555   1555  2.57
LINK         OD1 ASP H 235                CA    CA H 301     1555   1555  2.67
LINK         OD2 ASP H 235                CA    CA H 301     1555   1555  2.49
LINK         OD1 ASP H 262                CA    CA H 301     1555   1555  2.32
LINK         OD1 ASP I 234                CA    CA I 301     1555   1555  2.62
LINK         OD2 ASP I 234                CA    CA I 301     1555   1555  2.53
LINK         OD1 ASP I 235                CA    CA I 301     1555   1555  2.48
LINK         OD2 ASP I 235                CA    CA I 301     1555   1555  2.54
LINK         OE2 GLU I 257                CA    CA J 301     1555   1555  2.51
LINK         OD1 ASP I 262                CA    CA I 301     1555   1555  2.44
LINK         OD1 ASP J 234                CA    CA J 301     1555   1555  2.61
LINK         OD2 ASP J 234                CA    CA J 301     1555   1555  2.67
LINK         OD1 ASP J 235                CA    CA J 301     1555   1555  2.64
LINK         OD2 ASP J 235                CA    CA J 301     1555   1555  2.55
LINK         OD1 ASP J 262                CA    CA J 301     1555   1555  2.36
CRYST1  113.385  160.164  192.056  90.00  90.00  90.00 P 21 21 21   40
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.008820  0.000000  0.000000        0.00000
SCALE2      0.000000  0.006244  0.000000        0.00000
SCALE3      0.000000  0.000000  0.005207        0.00000
TER    2154      TYR A 288
TER    4312      TYR B 288
TER    6470      TYR C 288
TER    8611      TYR D 288
TER   10765      TYR E 288
TER   12919      TYR F 288
TER   15064      TYR G 288
TER   17209      TYR H 288
TER   19359      TYR I 288
TER   21509      TYR J 288
MASTER      723    0   19  142  110    0    0    623458   10  151  230
END