longtext: 7ym9-pdb

content
HEADER    HYDROLASE                               28-JUL-22   7YM9
TITLE     CRYSTAL STRUCTURE OF A PET HYDROLASE FROM CRYPTOSPORANGIUM AURANTIACUM
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: POLY(ETHYLENE TEREPHTHALATE) HYDROLASE;
COMPND   3 CHAIN: A, B;
COMPND   4 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: CRYPTOSPORANGIUM AURANTIACUM;
SOURCE   3 ORGANISM_TAXID: 134849;
SOURCE   4 GENE: SAMN05443668_101498;
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 562
KEYWDS    POLY(ETHYLENE TEREPHTHALATE) HYDROLASE, ESTERASE, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    H.HONG,D.KI,K.-J.KIM
REVDAT   1   12-JUL-23 7YM9    0
JRNL        AUTH   H.HONG,D.KI,K.-J.KIM
JRNL        TITL   EMERGENCE OF A NEWLY IDENTIFIED PETASE FROM CRYPTOSPORANGIUM
JRNL        TITL 2 AURANTIACUM: FROM CHARACTERIZATION TO ENGINEERING FOR
JRNL        TITL 3 EFFICIENT PET DECOMPOSITION
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   2
REMARK   2 RESOLUTION.    1.34 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.8.0267
REMARK   3   AUTHORS     : MURSHUDOV,SKUBAK,LEBEDEV,PANNU,STEINER,
REMARK   3               : NICHOLLS,WINN,LONG,VAGIN
REMARK   3
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.34
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 26.23
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0.000
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.7
REMARK   3   NUMBER OF REFLECTIONS             : 126891
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.173
REMARK   3   R VALUE            (WORKING SET) : 0.172
REMARK   3   FREE R VALUE                     : 0.183
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.800
REMARK   3   FREE R VALUE TEST SET COUNT      : 6373
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 1.34
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 1.38
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 9152
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 98.55
REMARK   3   BIN R VALUE           (WORKING SET) : 0.2140
REMARK   3   BIN FREE R VALUE SET COUNT          : 505
REMARK   3   BIN FREE R VALUE                    : 0.2250
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 3902
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 14
REMARK   3   SOLVENT ATOMS            : 470
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 13.76
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : 0.51000
REMARK   3    B22 (A**2) : -0.80000
REMARK   3    B33 (A**2) : 0.28000
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : 0.00000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): 0.047
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.047
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.028
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 0.661
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.967
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.963
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A):  4097 ; 0.016 ; 0.013
REMARK   3   BOND LENGTHS OTHERS               (A):  3720 ; 0.001 ; 0.014
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES):  5625 ; 2.008 ; 1.647
REMARK   3   BOND ANGLES OTHERS          (DEGREES):  8555 ; 1.581 ; 1.572
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):   532 ; 6.885 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   202 ;29.392 ;20.990
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):   563 ;10.744 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):    30 ;17.153 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):   545 ; 0.115 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A):  4795 ; 0.013 ; 0.020
REMARK   3   GENERAL PLANES OTHERS             (A):  1017 ; 0.001 ; 0.020
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN ANGLE OTHER ATOMS   (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN ANGLE OTHER ATOMS   (A**2):  NULL ;  NULL ;  NULL
REMARK   3   LONG RANGE B REFINED ATOMS     (A**2):  NULL ;  NULL ;  NULL
REMARK   3   LONG RANGE B OTHER ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : MASK
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.20
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE RIDING
REMARK   3  POSITIONS U VALUES : REFINED INDIVIDUALLY
REMARK   4
REMARK   4 7YM9 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 29-JUL-22.
REMARK 100 THE DEPOSITION ID IS D_1300031243.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 25-MAY-20
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : NULL
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : PAL/PLS
REMARK 200  BEAMLINE                       : 7A (6B, 6C1)
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.97934
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 270
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000
REMARK 200  DATA SCALING SOFTWARE          : HKL-2000
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 133383
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.340
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.9
REMARK 200  DATA REDUNDANCY                : 12.40
REMARK 200  R MERGE                    (I) : 0.08200
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 10.0000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.34
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.36
REMARK 200  COMPLETENESS FOR SHELL     (%) : 100.0
REMARK 200  DATA REDUNDANCY IN SHELL       : 10.40
REMARK 200  R MERGE FOR SHELL          (I) : 0.51200
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: MOLREP
REMARK 200 STARTING MODEL: 5LUL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 54.25
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.69
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 12% (W/V) PEG3350, 0.1 M SODIUM
REMARK 280  MALONATE PH4.0, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 293K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 2
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,-Y,Z
REMARK 290       3555   -X+1/2,Y+1/2,-Z
REMARK 290       4555   X+1/2,-Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000       41.15450
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       41.22450
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       41.15450
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       41.22450
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A    40
REMARK 465     ALA A    41
REMARK 465     ALA A    42
REMARK 465     LEU A   300
REMARK 465     GLU A   301
REMARK 465     HIS A   302
REMARK 465     HIS A   303
REMARK 465     HIS A   304
REMARK 465     HIS A   305
REMARK 465     HIS A   306
REMARK 465     HIS A   307
REMARK 465     MET B    40
REMARK 465     ALA B    41
REMARK 465     ALA B    42
REMARK 465     LEU B   300
REMARK 465     GLU B   301
REMARK 465     HIS B   302
REMARK 465     HIS B   303
REMARK 465     HIS B   304
REMARK 465     HIS B   305
REMARK 465     HIS B   306
REMARK 465     HIS B   307
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    SER A 169     -131.61     60.99
REMARK 500    HIS A 223      -89.70   -132.25
REMARK 500    ASN B  44      117.75   -167.22
REMARK 500    ILE B 102       29.58     48.94
REMARK 500    SER B 169     -130.05     61.35
REMARK 500    HIS B 223      -90.17   -121.27
REMARK 500
REMARK 500 REMARK: NULL
DBREF1 7YM9 A   41   299  UNP                  A0A1M7II12_9ACTN
DBREF2 7YM9 A     A0A1M7II12                         41         299
DBREF1 7YM9 B   41   299  UNP                  A0A1M7II12_9ACTN
DBREF2 7YM9 B     A0A1M7II12                         41         299
SEQADV 7YM9 MET A   40  UNP  A0A1M7II1           INITIATING METHIONINE
SEQADV 7YM9 LEU A  300  UNP  A0A1M7II1           EXPRESSION TAG
SEQADV 7YM9 GLU A  301  UNP  A0A1M7II1           EXPRESSION TAG
SEQADV 7YM9 HIS A  302  UNP  A0A1M7II1           EXPRESSION TAG
SEQADV 7YM9 HIS A  303  UNP  A0A1M7II1           EXPRESSION TAG
SEQADV 7YM9 HIS A  304  UNP  A0A1M7II1           EXPRESSION TAG
SEQADV 7YM9 HIS A  305  UNP  A0A1M7II1           EXPRESSION TAG
SEQADV 7YM9 HIS A  306  UNP  A0A1M7II1           EXPRESSION TAG
SEQADV 7YM9 HIS A  307  UNP  A0A1M7II1           EXPRESSION TAG
SEQADV 7YM9 MET B   40  UNP  A0A1M7II1           INITIATING METHIONINE
SEQADV 7YM9 LEU B  300  UNP  A0A1M7II1           EXPRESSION TAG
SEQADV 7YM9 GLU B  301  UNP  A0A1M7II1           EXPRESSION TAG
SEQADV 7YM9 HIS B  302  UNP  A0A1M7II1           EXPRESSION TAG
SEQADV 7YM9 HIS B  303  UNP  A0A1M7II1           EXPRESSION TAG
SEQADV 7YM9 HIS B  304  UNP  A0A1M7II1           EXPRESSION TAG
SEQADV 7YM9 HIS B  305  UNP  A0A1M7II1           EXPRESSION TAG
SEQADV 7YM9 HIS B  306  UNP  A0A1M7II1           EXPRESSION TAG
SEQADV 7YM9 HIS B  307  UNP  A0A1M7II1           EXPRESSION TAG
SEQRES   1 A  268  MET ALA ALA ASP ASN PRO TYR GLN ARG GLY PRO ASP PRO
SEQRES   2 A  268  THR ASN ALA SER ILE GLU ALA ALA THR GLY PRO PHE ALA
SEQRES   3 A  268  VAL GLY THR GLN PRO ILE VAL GLY ALA SER GLY PHE GLY
SEQRES   4 A  268  GLY GLY GLN ILE TYR TYR PRO THR ASP THR SER GLN THR
SEQRES   5 A  268  TYR GLY ALA VAL VAL ILE VAL PRO GLY PHE ILE SER VAL
SEQRES   6 A  268  TRP ALA GLN LEU ASN TRP LEU GLY PRO ARG LEU ALA SER
SEQRES   7 A  268  GLN GLY PHE VAL VAL ILE GLY ILE GLU THR SER VAL ILE
SEQRES   8 A  268  THR ASP LEU PRO ASP PRO ARG GLY ASP GLN ALA LEU ALA
SEQRES   9 A  268  ALA LEU ASP TRP ALA THR THR ARG SER PRO VAL ALA SER
SEQRES  10 A  268  ARG ILE ASP ARG THR ARG LEU ALA ALA ALA GLY TRP SER
SEQRES  11 A  268  MET GLY GLY GLY GLY LEU ARG ARG ALA ALA LEU GLN ARG
SEQRES  12 A  268  PRO SER LEU LYS ALA ILE VAL GLY MET ALA PRO TRP ASN
SEQRES  13 A  268  GLY GLU ARG ASN TRP SER ALA VAL THR VAL PRO THR LEU
SEQRES  14 A  268  PHE PHE GLY GLY SER SER ASP ALA VAL ALA SER PRO ASN
SEQRES  15 A  268  ASP HIS ALA LYS PRO PHE TYR ASN SER ILE THR ARG ALA
SEQRES  16 A  268  GLU LYS ASP TYR ILE GLU LEU ARG ASN ALA ASP HIS PHE
SEQRES  17 A  268  PHE PRO THR SER ALA ASN THR THR MET ALA LYS TYR PHE
SEQRES  18 A  268  ILE SER TRP LEU LYS ARG TRP VAL ASP ASN ASP THR ARG
SEQRES  19 A  268  TYR THR GLN PHE LEU CYS PRO GLY PRO SER THR GLY LEU
SEQRES  20 A  268  PHE ALA PRO VAL SER ALA SER MET ASN THR CYS PRO PHE
SEQRES  21 A  268  LEU GLU HIS HIS HIS HIS HIS HIS
SEQRES   1 B  268  MET ALA ALA ASP ASN PRO TYR GLN ARG GLY PRO ASP PRO
SEQRES   2 B  268  THR ASN ALA SER ILE GLU ALA ALA THR GLY PRO PHE ALA
SEQRES   3 B  268  VAL GLY THR GLN PRO ILE VAL GLY ALA SER GLY PHE GLY
SEQRES   4 B  268  GLY GLY GLN ILE TYR TYR PRO THR ASP THR SER GLN THR
SEQRES   5 B  268  TYR GLY ALA VAL VAL ILE VAL PRO GLY PHE ILE SER VAL
SEQRES   6 B  268  TRP ALA GLN LEU ASN TRP LEU GLY PRO ARG LEU ALA SER
SEQRES   7 B  268  GLN GLY PHE VAL VAL ILE GLY ILE GLU THR SER VAL ILE
SEQRES   8 B  268  THR ASP LEU PRO ASP PRO ARG GLY ASP GLN ALA LEU ALA
SEQRES   9 B  268  ALA LEU ASP TRP ALA THR THR ARG SER PRO VAL ALA SER
SEQRES  10 B  268  ARG ILE ASP ARG THR ARG LEU ALA ALA ALA GLY TRP SER
SEQRES  11 B  268  MET GLY GLY GLY GLY LEU ARG ARG ALA ALA LEU GLN ARG
SEQRES  12 B  268  PRO SER LEU LYS ALA ILE VAL GLY MET ALA PRO TRP ASN
SEQRES  13 B  268  GLY GLU ARG ASN TRP SER ALA VAL THR VAL PRO THR LEU
SEQRES  14 B  268  PHE PHE GLY GLY SER SER ASP ALA VAL ALA SER PRO ASN
SEQRES  15 B  268  ASP HIS ALA LYS PRO PHE TYR ASN SER ILE THR ARG ALA
SEQRES  16 B  268  GLU LYS ASP TYR ILE GLU LEU ARG ASN ALA ASP HIS PHE
SEQRES  17 B  268  PHE PRO THR SER ALA ASN THR THR MET ALA LYS TYR PHE
SEQRES  18 B  268  ILE SER TRP LEU LYS ARG TRP VAL ASP ASN ASP THR ARG
SEQRES  19 B  268  TYR THR GLN PHE LEU CYS PRO GLY PRO SER THR GLY LEU
SEQRES  20 B  268  PHE ALA PRO VAL SER ALA SER MET ASN THR CYS PRO PHE
SEQRES  21 B  268  LEU GLU HIS HIS HIS HIS HIS HIS
HET    MLI  A 401       7
HET    MLI  B 401       7
HETNAM     MLI MALONATE ION
FORMUL   3  MLI    2(C3 H2 O4 2-)
FORMUL   5  HOH   *470(H2 O)
HELIX    1 AA1 THR A   53  ALA A   59  1                                   7
HELIX    2 AA2 VAL A  104  ASN A  109  5                                   6
HELIX    3 AA3 TRP A  110  SER A  117  1                                   8
HELIX    4 AA4 LEU A  133  ARG A  151  1                                  19
HELIX    5 AA5 VAL A  154  SER A  156  5                                   3
HELIX    6 AA6 SER A  169  GLY A  174  1                                   6
HELIX    7 AA7 GLY A  174  ARG A  182  1                                   9
HELIX    8 AA8 HIS A  223  ILE A  231  1                                   9
HELIX    9 AA9 PHE A  247  SER A  251  5                                   5
HELIX   10 AB1 ASN A  253  ASP A  269  1                                  17
HELIX   11 AB2 ASP A  271  ARG A  273  5                                   3
HELIX   12 AB3 TYR A  274  CYS A  279  1                                   6
HELIX   13 AB4 THR B   53  ALA B   59  1                                   7
HELIX   14 AB5 VAL B  104  ASN B  109  5                                   6
HELIX   15 AB6 TRP B  110  SER B  117  1                                   8
HELIX   16 AB7 LEU B  133  ARG B  151  1                                  19
HELIX   17 AB8 VAL B  154  SER B  156  5                                   3
HELIX   18 AB9 SER B  169  GLY B  174  1                                   6
HELIX   19 AC1 GLY B  174  ARG B  182  1                                   9
HELIX   20 AC2 HIS B  223  ILE B  231  1                                   9
HELIX   21 AC3 PHE B  247  SER B  251  5                                   5
HELIX   22 AC4 ASN B  253  ASP B  269  1                                  17
HELIX   23 AC5 ASP B  271  ARG B  273  5                                   3
HELIX   24 AC6 TYR B  274  CYS B  279  1                                   6
SHEET    1 AA1 9 VAL A  66  PRO A  70  0
SHEET    2 AA1 9 GLY A  80  PRO A  85 -1  O  TYR A  84   N  GLY A  67
SHEET    3 AA1 9 VAL A 121  ILE A 125 -1  O  VAL A 122   N  TYR A  83
SHEET    4 AA1 9 TYR A  92  VAL A  98  1  N  VAL A  95   O  ILE A 123
SHEET    5 AA1 9 ILE A 158  TRP A 168  1  O  ASP A 159   N  TYR A  92
SHEET    6 AA1 9 ALA A 187  MET A 191  1  O  MET A 191   N  GLY A 167
SHEET    7 AA1 9 THR A 207  GLY A 212  1  O  LEU A 208   N  GLY A 190
SHEET    8 AA1 9 LYS A 236  LEU A 241  1  O  LEU A 241   N  GLY A 211
SHEET    9 AA1 9 VAL A 290  ASN A 295 -1  O  MET A 294   N  TYR A 238
SHEET    1 AA2 9 VAL B  66  PRO B  70  0
SHEET    2 AA2 9 GLY B  80  PRO B  85 -1  O  TYR B  84   N  GLY B  67
SHEET    3 AA2 9 VAL B 121  ILE B 125 -1  O  VAL B 122   N  TYR B  83
SHEET    4 AA2 9 TYR B  92  VAL B  98  1  N  ILE B  97   O  ILE B 123
SHEET    5 AA2 9 ILE B 158  TRP B 168  1  O  ALA B 166   N  VAL B  96
SHEET    6 AA2 9 ALA B 187  MET B 191  1  O  MET B 191   N  GLY B 167
SHEET    7 AA2 9 THR B 207  GLY B 212  1  O  PHE B 210   N  GLY B 190
SHEET    8 AA2 9 LYS B 236  LEU B 241  1  O  LEU B 241   N  GLY B 211
SHEET    9 AA2 9 VAL B 290  ASN B 295 -1  O  MET B 294   N  TYR B 238
SSBOND   1 CYS A  279    CYS A  297                          1555   1555  2.08
SSBOND   2 CYS B  279    CYS B  297                          1555   1555  2.06
CISPEP   1 CYS A  279    PRO A  280          0         7.24
CISPEP   2 CYS A  297    PRO A  298          0        -0.36
CISPEP   3 CYS B  279    PRO B  280          0         7.82
CISPEP   4 CYS B  297    PRO B  298          0         4.40
CRYST1   82.309   82.449   87.391  90.00  90.00  90.00 P 21 21 2     8
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.012149  0.000000  0.000000        0.00000
SCALE2      0.000000  0.012129  0.000000        0.00000
SCALE3      0.000000  0.000000  0.011443        0.00000
TER    1978      PHE A 299
TER    3957      PHE B 299
MASTER      293    0    2   24   18    0    0    6 4386    2   18   42
END