longtext: 8b5k-pdb

content
HEADER    HYDROLASE                               23-SEP-22   8B5K
TITLE     STRUCTURE OF HALOALKANE DEHALOGENASE DMMARA FROM MYCOBACTERIUM MARINUM
TITLE    2 AT PH 6.5
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: HALOALKANE DEHALOGENASE DHAA;
COMPND   3 CHAIN: A, B, C, D;
COMPND   4 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: MYCOBACTERIUM MARINUM;
SOURCE   3 ORGANISM_TAXID: 1781;
SOURCE   4 GENE: DHAA, MMAR_4113;
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 562
KEYWDS    HALOALKANE DEHALOGENASE, ENZYME, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    K.SNAJDAROVA,M.MAREK
REVDAT   1   30-AUG-23 8B5K    0
JRNL        AUTH   K.SNAJDAROVA,M.MAREK
JRNL        TITL   STRUCTURE OF HALOALKANE DEHALOGENASE DMMARA FROM
JRNL        TITL 2 MYCOBACTERIUM MARINUM AT PH 6.5
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   2
REMARK   2 RESOLUTION.    1.85 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX 1.14-3260
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : ML
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.85
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 44.07
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.340
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.8
REMARK   3   NUMBER OF REFLECTIONS             : 97478
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.194
REMARK   3   R VALUE            (WORKING SET) : 0.191
REMARK   3   FREE R VALUE                     : 0.241
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.920
REMARK   3   FREE R VALUE TEST SET COUNT      : 4800
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 44.0730 -  5.7426    1.00     3232   173  0.1609 0.1910
REMARK   3     2  5.7426 -  4.5596    1.00     3139   182  0.1406 0.1837
REMARK   3     3  4.5596 -  3.9836    1.00     3110   161  0.1310 0.1552
REMARK   3     4  3.9836 -  3.6196    1.00     3110   158  0.1491 0.1819
REMARK   3     5  3.6196 -  3.3603    1.00     3140   157  0.1643 0.2045
REMARK   3     6  3.3603 -  3.1622    1.00     3100   159  0.1758 0.2341
REMARK   3     7  3.1622 -  3.0039    1.00     3092   172  0.1976 0.2502
REMARK   3     8  3.0039 -  2.8731    1.00     3089   176  0.1935 0.2387
REMARK   3     9  2.8731 -  2.7626    1.00     3084   165  0.1892 0.2612
REMARK   3    10  2.7626 -  2.6672    1.00     3098   153  0.2011 0.2590
REMARK   3    11  2.6672 -  2.5838    1.00     3101   161  0.1962 0.2617
REMARK   3    12  2.5838 -  2.5100    1.00     3094   158  0.2034 0.2558
REMARK   3    13  2.5100 -  2.4439    1.00     3080   174  0.2010 0.2744
REMARK   3    14  2.4439 -  2.3843    1.00     3099   145  0.2054 0.2616
REMARK   3    15  2.3843 -  2.3301    1.00     3122   149  0.2011 0.3011
REMARK   3    16  2.3301 -  2.2805    1.00     3040   152  0.2078 0.2626
REMARK   3    17  2.2805 -  2.2349    1.00     3116   152  0.2259 0.2992
REMARK   3    18  2.2349 -  2.1927    1.00     3056   159  0.2200 0.2794
REMARK   3    19  2.1927 -  2.1536    1.00     3113   155  0.2181 0.2865
REMARK   3    20  2.1536 -  2.1171    1.00     3049   154  0.2230 0.3019
REMARK   3    21  2.1171 -  2.0829    1.00     3116   151  0.2298 0.3124
REMARK   3    22  2.0829 -  2.0509    1.00     3059   128  0.2487 0.3060
REMARK   3    23  2.0509 -  2.0207    1.00     3123   165  0.2492 0.3280
REMARK   3    24  2.0207 -  1.9922    1.00     3086   159  0.2504 0.3167
REMARK   3    25  1.9922 -  1.9653    1.00     3062   153  0.2445 0.2955
REMARK   3    26  1.9653 -  1.9398    1.00     3062   173  0.2633 0.2768
REMARK   3    27  1.9398 -  1.9156    1.00     3025   159  0.2971 0.3863
REMARK   3    28  1.9156 -  1.8925    1.00     3109   172  0.3016 0.3616
REMARK   3    29  1.8925 -  1.8705    1.00     2986   173  0.3106 0.3245
REMARK   3    30  1.8705 -  1.8494    0.95     2986   152  0.3443 0.3789
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL
REMARK   3   SOLVENT RADIUS     : 1.11
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.260
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 26.920
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 28.13
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :   NULL           NULL
REMARK   3   ANGLE     :   NULL           NULL
REMARK   3   CHIRALITY :   NULL           NULL
REMARK   3   PLANARITY :   NULL           NULL
REMARK   3   DIHEDRAL  :   NULL           NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : 1
REMARK   3   TLS GROUP : 1
REMARK   3    SELECTION: ALL
REMARK   3    ORIGIN FOR THE GROUP (A):  36.2516  -6.9044  26.7575
REMARK   3    T TENSOR
REMARK   3      T11:   0.2614 T22:   0.1224
REMARK   3      T33:   0.1343 T12:  -0.0021
REMARK   3      T13:   0.0074 T23:  -0.0020
REMARK   3    L TENSOR
REMARK   3      L11:   0.2385 L22:   0.2788
REMARK   3      L33:   0.2028 L12:   0.0009
REMARK   3      L13:   0.0577 L23:  -0.0128
REMARK   3    S TENSOR
REMARK   3      S11:   0.0090 S12:  -0.0097 S13:  -0.0075
REMARK   3      S21:  -0.1240 S22:  -0.0001 S23:   0.0187
REMARK   3      S31:   0.0530 S32:   0.0191 S33:  -0.0095
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 8B5K COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 23-SEP-22.
REMARK 100 THE DEPOSITION ID IS D_1292125774.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 13-OCT-19
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 6.5
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : SLS
REMARK 200  BEAMLINE                       : X06DA
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : PIXEL
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS PILATUS 2M-F
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200  DATA SCALING SOFTWARE          : AIMLESS 0.7.4
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 97565
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.849
REMARK 200  RESOLUTION RANGE LOW       (A) : 48.370
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.8
REMARK 200  DATA REDUNDANCY                : 6.700
REMARK 200  R MERGE                    (I) : 0.15100
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 10.0000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.85
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.88
REMARK 200  COMPLETENESS FOR SHELL     (%) : 97.1
REMARK 200  DATA REDUNDANCY IN SHELL       : 5.80
REMARK 200  R MERGE FOR SHELL          (I) : 1.66200
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: 1MJ5
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 43.36
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.17
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: POTASSIUM PHOSPHATE, BIS-TRIS PROPANE,
REMARK 280  PEG 3350, PH 6.5, VAPOR DIFFUSION, SITTING DROP, TEMPERATURE
REMARK 280  293.15K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000       30.69050
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C, D
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     ASP A   285
REMARK 465     GLY A   286
REMARK 465     ALA A   287
REMARK 465     ASP A   288
REMARK 465     ARG A   289
REMARK 465     ALA A   290
REMARK 465     HIS A   291
REMARK 465     HIS A   292
REMARK 465     HIS A   293
REMARK 465     HIS A   294
REMARK 465     HIS A   295
REMARK 465     HIS A   296
REMARK 465     ASP B   285
REMARK 465     GLY B   286
REMARK 465     ALA B   287
REMARK 465     ASP B   288
REMARK 465     ARG B   289
REMARK 465     ALA B   290
REMARK 465     HIS B   291
REMARK 465     HIS B   292
REMARK 465     HIS B   293
REMARK 465     HIS B   294
REMARK 465     HIS B   295
REMARK 465     HIS B   296
REMARK 465     ASP C   285
REMARK 465     GLY C   286
REMARK 465     ALA C   287
REMARK 465     ASP C   288
REMARK 465     ARG C   289
REMARK 465     ALA C   290
REMARK 465     HIS C   291
REMARK 465     HIS C   292
REMARK 465     HIS C   293
REMARK 465     HIS C   294
REMARK 465     HIS C   295
REMARK 465     HIS C   296
REMARK 465     GLN D   284
REMARK 465     ASP D   285
REMARK 465     GLY D   286
REMARK 465     ALA D   287
REMARK 465     ASP D   288
REMARK 465     ARG D   289
REMARK 465     ALA D   290
REMARK 465     HIS D   291
REMARK 465     HIS D   292
REMARK 465     HIS D   293
REMARK 465     HIS D   294
REMARK 465     HIS D   295
REMARK 465     HIS D   296
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    LEU A   7     -124.37     51.49
REMARK 500    PRO A  29       50.20   -103.10
REMARK 500    THR A  30     -155.52   -100.92
REMARK 500    ASP A  95     -132.17     57.70
REMARK 500    ASP A 119       61.16     33.31
REMARK 500    THR A 131     -115.12     36.54
REMARK 500    ALA A 232      -84.28   -145.50
REMARK 500    ARG A 258     -139.25    -98.87
REMARK 500    ARG A 283       56.04   -106.27
REMARK 500    LEU B   7     -116.22     45.00
REMARK 500    SER B   9     -157.77   -142.96
REMARK 500    PRO B  29       51.22   -105.09
REMARK 500    THR B  30     -147.91   -104.53
REMARK 500    SER B  31     -177.42   -172.70
REMARK 500    ASP B  95     -136.14     57.92
REMARK 500    ASP B 119       66.26     33.63
REMARK 500    THR B 131     -124.26     47.87
REMARK 500    ALA B 232      -70.96   -142.90
REMARK 500    ARG B 258     -134.50   -103.48
REMARK 500    LEU C   7     -124.63     49.58
REMARK 500    PRO C  29       53.21    -98.97
REMARK 500    THR C  30     -156.61   -105.98
REMARK 500    ASP C  95     -134.93     55.83
REMARK 500    ASP C 119       65.63     27.09
REMARK 500    THR C 131     -124.73     42.28
REMARK 500    ALA C 232      -80.73   -148.40
REMARK 500    ARG C 258     -143.30    -89.37
REMARK 500    LEU D   7     -124.91     51.67
REMARK 500    PRO D  29       55.96   -109.59
REMARK 500    THR D  30     -151.06   -102.33
REMARK 500    ASP D  95     -132.29     57.31
REMARK 500    ASP D 119       75.38     35.45
REMARK 500    THR D 131     -130.92     47.18
REMARK 500    LYS D 158      -45.20   -130.69
REMARK 500    ALA D 232      -72.11   -153.52
REMARK 500    ARG D 258     -138.55   -101.44
REMARK 500
REMARK 500 REMARK: NULL
REMARK 525
REMARK 525 SOLVENT
REMARK 525
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 525 NUMBER; I=INSERTION CODE):
REMARK 525
REMARK 525  M RES CSSEQI
REMARK 525    HOH A 533        DISTANCE =  7.97 ANGSTROMS
REMARK 525    HOH A 534        DISTANCE =  8.17 ANGSTROMS
REMARK 525    HOH B 556        DISTANCE =  6.06 ANGSTROMS
REMARK 525    HOH C 694        DISTANCE =  8.46 ANGSTROMS
REMARK 525    HOH D 495        DISTANCE =  5.90 ANGSTROMS
DBREF  8B5K A    1   290  UNP    B2HR89   B2HR89_MYCMM     1    290
DBREF  8B5K B    1   290  UNP    B2HR89   B2HR89_MYCMM     1    290
DBREF  8B5K C    1   290  UNP    B2HR89   B2HR89_MYCMM     1    290
DBREF  8B5K D    1   290  UNP    B2HR89   B2HR89_MYCMM     1    290
SEQADV 8B5K HIS A  291  UNP  B2HR89              EXPRESSION TAG
SEQADV 8B5K HIS A  292  UNP  B2HR89              EXPRESSION TAG
SEQADV 8B5K HIS A  293  UNP  B2HR89              EXPRESSION TAG
SEQADV 8B5K HIS A  294  UNP  B2HR89              EXPRESSION TAG
SEQADV 8B5K HIS A  295  UNP  B2HR89              EXPRESSION TAG
SEQADV 8B5K HIS A  296  UNP  B2HR89              EXPRESSION TAG
SEQADV 8B5K HIS B  291  UNP  B2HR89              EXPRESSION TAG
SEQADV 8B5K HIS B  292  UNP  B2HR89              EXPRESSION TAG
SEQADV 8B5K HIS B  293  UNP  B2HR89              EXPRESSION TAG
SEQADV 8B5K HIS B  294  UNP  B2HR89              EXPRESSION TAG
SEQADV 8B5K HIS B  295  UNP  B2HR89              EXPRESSION TAG
SEQADV 8B5K HIS B  296  UNP  B2HR89              EXPRESSION TAG
SEQADV 8B5K HIS C  291  UNP  B2HR89              EXPRESSION TAG
SEQADV 8B5K HIS C  292  UNP  B2HR89              EXPRESSION TAG
SEQADV 8B5K HIS C  293  UNP  B2HR89              EXPRESSION TAG
SEQADV 8B5K HIS C  294  UNP  B2HR89              EXPRESSION TAG
SEQADV 8B5K HIS C  295  UNP  B2HR89              EXPRESSION TAG
SEQADV 8B5K HIS C  296  UNP  B2HR89              EXPRESSION TAG
SEQADV 8B5K HIS D  291  UNP  B2HR89              EXPRESSION TAG
SEQADV 8B5K HIS D  292  UNP  B2HR89              EXPRESSION TAG
SEQADV 8B5K HIS D  293  UNP  B2HR89              EXPRESSION TAG
SEQADV 8B5K HIS D  294  UNP  B2HR89              EXPRESSION TAG
SEQADV 8B5K HIS D  295  UNP  B2HR89              EXPRESSION TAG
SEQADV 8B5K HIS D  296  UNP  B2HR89              EXPRESSION TAG
SEQRES   1 A  296  MET LYS ARG VAL ASP VAL LEU ASP SER ALA MET SER TYR
SEQRES   2 A  296  ILE ASP VAL GLY GLN GLY ASP PRO ILE VAL PHE LEU HIS
SEQRES   3 A  296  GLY ASN PRO THR SER SER TYR LEU TRP ARG ASN VAL ILE
SEQRES   4 A  296  PRO HIS LEU SER ASP VAL GLY ARG CYS LEU ALA PRO ASP
SEQRES   5 A  296  LEU ILE GLY MET GLY ALA SER GLY THR SER PRO THR PHE
SEQRES   6 A  296  SER TYR ARG PHE ALA ASP HIS VAL ARG TYR LEU ASP ALA
SEQRES   7 A  296  TRP PHE GLU ALA VAL GLY ILE THR GLU ASN VAL VAL LEU
SEQRES   8 A  296  VAL VAL HIS ASP TRP GLY SER ALA LEU GLY PHE TYR ARG
SEQRES   9 A  296  ALA LEU ARG TYR PRO GLU GLN ILE ALA GLY ILE ALA TYR
SEQRES  10 A  296  MET ASP ALA LEU VAL GLN PRO ARG THR TRP ALA GLY PHE
SEQRES  11 A  296  THR ASP TYR GLU PRO LEU MET ARG ALA LEU ARG THR GLU
SEQRES  12 A  296  GLN GLY GLU ARG MET ALA LEU ALA GLU ASN VAL PHE VAL
SEQRES  13 A  296  GLU LYS VAL VAL PRO GLY GLY VAL GLN ARG GLN LEU THR
SEQRES  14 A  296  GLU GLU GLU MET ALA VAL TYR ARG THR PRO TYR PRO THR
SEQRES  15 A  296  PRO GLN SER ARG ILE PRO THR LEU LEU TRP ALA ARG GLU
SEQRES  16 A  296  ILE PRO VAL GLU GLY GLU PRO ALA ASP VAL GLN ALA MET
SEQRES  17 A  296  VAL GLN GLU TYR ALA ASP PHE LEU SER ARG SER ASP ILE
SEQRES  18 A  296  PRO LYS LEU LEU ILE VAL ALA GLU PRO GLY ALA ILE LEU
SEQRES  19 A  296  HIS GLU GLY GLY SER GLU LEU ASP PHE ALA ARG SER TRP
SEQRES  20 A  296  PRO ASN GLN ARG GLU VAL LYS VAL ALA GLY ARG HIS PHE
SEQRES  21 A  296  LEU GLN GLU ASP SER PRO ASP ALA ILE GLY ALA ALA VAL
SEQRES  22 A  296  ARG ALA PHE VAL LEU ASP VAL ARG GLU ARG GLN ASP GLY
SEQRES  23 A  296  ALA ASP ARG ALA HIS HIS HIS HIS HIS HIS
SEQRES   1 B  296  MET LYS ARG VAL ASP VAL LEU ASP SER ALA MET SER TYR
SEQRES   2 B  296  ILE ASP VAL GLY GLN GLY ASP PRO ILE VAL PHE LEU HIS
SEQRES   3 B  296  GLY ASN PRO THR SER SER TYR LEU TRP ARG ASN VAL ILE
SEQRES   4 B  296  PRO HIS LEU SER ASP VAL GLY ARG CYS LEU ALA PRO ASP
SEQRES   5 B  296  LEU ILE GLY MET GLY ALA SER GLY THR SER PRO THR PHE
SEQRES   6 B  296  SER TYR ARG PHE ALA ASP HIS VAL ARG TYR LEU ASP ALA
SEQRES   7 B  296  TRP PHE GLU ALA VAL GLY ILE THR GLU ASN VAL VAL LEU
SEQRES   8 B  296  VAL VAL HIS ASP TRP GLY SER ALA LEU GLY PHE TYR ARG
SEQRES   9 B  296  ALA LEU ARG TYR PRO GLU GLN ILE ALA GLY ILE ALA TYR
SEQRES  10 B  296  MET ASP ALA LEU VAL GLN PRO ARG THR TRP ALA GLY PHE
SEQRES  11 B  296  THR ASP TYR GLU PRO LEU MET ARG ALA LEU ARG THR GLU
SEQRES  12 B  296  GLN GLY GLU ARG MET ALA LEU ALA GLU ASN VAL PHE VAL
SEQRES  13 B  296  GLU LYS VAL VAL PRO GLY GLY VAL GLN ARG GLN LEU THR
SEQRES  14 B  296  GLU GLU GLU MET ALA VAL TYR ARG THR PRO TYR PRO THR
SEQRES  15 B  296  PRO GLN SER ARG ILE PRO THR LEU LEU TRP ALA ARG GLU
SEQRES  16 B  296  ILE PRO VAL GLU GLY GLU PRO ALA ASP VAL GLN ALA MET
SEQRES  17 B  296  VAL GLN GLU TYR ALA ASP PHE LEU SER ARG SER ASP ILE
SEQRES  18 B  296  PRO LYS LEU LEU ILE VAL ALA GLU PRO GLY ALA ILE LEU
SEQRES  19 B  296  HIS GLU GLY GLY SER GLU LEU ASP PHE ALA ARG SER TRP
SEQRES  20 B  296  PRO ASN GLN ARG GLU VAL LYS VAL ALA GLY ARG HIS PHE
SEQRES  21 B  296  LEU GLN GLU ASP SER PRO ASP ALA ILE GLY ALA ALA VAL
SEQRES  22 B  296  ARG ALA PHE VAL LEU ASP VAL ARG GLU ARG GLN ASP GLY
SEQRES  23 B  296  ALA ASP ARG ALA HIS HIS HIS HIS HIS HIS
SEQRES   1 C  296  MET LYS ARG VAL ASP VAL LEU ASP SER ALA MET SER TYR
SEQRES   2 C  296  ILE ASP VAL GLY GLN GLY ASP PRO ILE VAL PHE LEU HIS
SEQRES   3 C  296  GLY ASN PRO THR SER SER TYR LEU TRP ARG ASN VAL ILE
SEQRES   4 C  296  PRO HIS LEU SER ASP VAL GLY ARG CYS LEU ALA PRO ASP
SEQRES   5 C  296  LEU ILE GLY MET GLY ALA SER GLY THR SER PRO THR PHE
SEQRES   6 C  296  SER TYR ARG PHE ALA ASP HIS VAL ARG TYR LEU ASP ALA
SEQRES   7 C  296  TRP PHE GLU ALA VAL GLY ILE THR GLU ASN VAL VAL LEU
SEQRES   8 C  296  VAL VAL HIS ASP TRP GLY SER ALA LEU GLY PHE TYR ARG
SEQRES   9 C  296  ALA LEU ARG TYR PRO GLU GLN ILE ALA GLY ILE ALA TYR
SEQRES  10 C  296  MET ASP ALA LEU VAL GLN PRO ARG THR TRP ALA GLY PHE
SEQRES  11 C  296  THR ASP TYR GLU PRO LEU MET ARG ALA LEU ARG THR GLU
SEQRES  12 C  296  GLN GLY GLU ARG MET ALA LEU ALA GLU ASN VAL PHE VAL
SEQRES  13 C  296  GLU LYS VAL VAL PRO GLY GLY VAL GLN ARG GLN LEU THR
SEQRES  14 C  296  GLU GLU GLU MET ALA VAL TYR ARG THR PRO TYR PRO THR
SEQRES  15 C  296  PRO GLN SER ARG ILE PRO THR LEU LEU TRP ALA ARG GLU
SEQRES  16 C  296  ILE PRO VAL GLU GLY GLU PRO ALA ASP VAL GLN ALA MET
SEQRES  17 C  296  VAL GLN GLU TYR ALA ASP PHE LEU SER ARG SER ASP ILE
SEQRES  18 C  296  PRO LYS LEU LEU ILE VAL ALA GLU PRO GLY ALA ILE LEU
SEQRES  19 C  296  HIS GLU GLY GLY SER GLU LEU ASP PHE ALA ARG SER TRP
SEQRES  20 C  296  PRO ASN GLN ARG GLU VAL LYS VAL ALA GLY ARG HIS PHE
SEQRES  21 C  296  LEU GLN GLU ASP SER PRO ASP ALA ILE GLY ALA ALA VAL
SEQRES  22 C  296  ARG ALA PHE VAL LEU ASP VAL ARG GLU ARG GLN ASP GLY
SEQRES  23 C  296  ALA ASP ARG ALA HIS HIS HIS HIS HIS HIS
SEQRES   1 D  296  MET LYS ARG VAL ASP VAL LEU ASP SER ALA MET SER TYR
SEQRES   2 D  296  ILE ASP VAL GLY GLN GLY ASP PRO ILE VAL PHE LEU HIS
SEQRES   3 D  296  GLY ASN PRO THR SER SER TYR LEU TRP ARG ASN VAL ILE
SEQRES   4 D  296  PRO HIS LEU SER ASP VAL GLY ARG CYS LEU ALA PRO ASP
SEQRES   5 D  296  LEU ILE GLY MET GLY ALA SER GLY THR SER PRO THR PHE
SEQRES   6 D  296  SER TYR ARG PHE ALA ASP HIS VAL ARG TYR LEU ASP ALA
SEQRES   7 D  296  TRP PHE GLU ALA VAL GLY ILE THR GLU ASN VAL VAL LEU
SEQRES   8 D  296  VAL VAL HIS ASP TRP GLY SER ALA LEU GLY PHE TYR ARG
SEQRES   9 D  296  ALA LEU ARG TYR PRO GLU GLN ILE ALA GLY ILE ALA TYR
SEQRES  10 D  296  MET ASP ALA LEU VAL GLN PRO ARG THR TRP ALA GLY PHE
SEQRES  11 D  296  THR ASP TYR GLU PRO LEU MET ARG ALA LEU ARG THR GLU
SEQRES  12 D  296  GLN GLY GLU ARG MET ALA LEU ALA GLU ASN VAL PHE VAL
SEQRES  13 D  296  GLU LYS VAL VAL PRO GLY GLY VAL GLN ARG GLN LEU THR
SEQRES  14 D  296  GLU GLU GLU MET ALA VAL TYR ARG THR PRO TYR PRO THR
SEQRES  15 D  296  PRO GLN SER ARG ILE PRO THR LEU LEU TRP ALA ARG GLU
SEQRES  16 D  296  ILE PRO VAL GLU GLY GLU PRO ALA ASP VAL GLN ALA MET
SEQRES  17 D  296  VAL GLN GLU TYR ALA ASP PHE LEU SER ARG SER ASP ILE
SEQRES  18 D  296  PRO LYS LEU LEU ILE VAL ALA GLU PRO GLY ALA ILE LEU
SEQRES  19 D  296  HIS GLU GLY GLY SER GLU LEU ASP PHE ALA ARG SER TRP
SEQRES  20 D  296  PRO ASN GLN ARG GLU VAL LYS VAL ALA GLY ARG HIS PHE
SEQRES  21 D  296  LEU GLN GLU ASP SER PRO ASP ALA ILE GLY ALA ALA VAL
SEQRES  22 D  296  ARG ALA PHE VAL LEU ASP VAL ARG GLU ARG GLN ASP GLY
SEQRES  23 D  296  ALA ASP ARG ALA HIS HIS HIS HIS HIS HIS
HET    GOL  A 301       6
HET    GOL  A 302       6
HET    FMT  A 303       3
HET    GOL  A 304       6
HET    GOL  B 301       6
HET    GOL  B 302       6
HET    FMT  B 303       3
HET    FMT  C 401       3
HET    GOL  C 402       6
HET    FMT  C 403       3
HET    FMT  C 404       3
HET    GOL  C 405       6
HET    GOL  C 406       6
HET    TRS  C 407       8
HET    GOL  C 408       6
HET    FMT  D 301       3
HET    FMT  D 302       3
HET    B3P  D 303      19
HETNAM     GOL GLYCEROL
HETNAM     FMT FORMIC ACID
HETNAM     TRS 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
HETNAM     B3P 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-
HETNAM   2 B3P  PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
HETSYN     GOL GLYCERIN; PROPANE-1,2,3-TRIOL
HETSYN     TRS TRIS BUFFER
FORMUL   5  GOL    9(C3 H8 O3)
FORMUL   7  FMT    7(C H2 O2)
FORMUL  18  TRS    C4 H12 N O3 1+
FORMUL  22  B3P    C11 H26 N2 O6
FORMUL  23  HOH   *579(H2 O)
HELIX    1 AA1 SER A   31  ARG A   36  5                                   6
HELIX    2 AA2 VAL A   38  LEU A   42  5                                   5
HELIX    3 AA3 ARG A   68  GLY A   84  1                                  17
HELIX    4 AA4 ASP A   95  TYR A  108  1                                  14
HELIX    5 AA5 TRP A  127  ASP A  132  5                                   6
HELIX    6 AA6 TYR A  133  ARG A  141  1                                   9
HELIX    7 AA7 GLN A  144  LEU A  150  1                                   7
HELIX    8 AA8 ASN A  153  LYS A  158  1                                   6
HELIX    9 AA9 LYS A  158  GLY A  163  1                                   6
HELIX   10 AB1 THR A  169  THR A  178  1                                  10
HELIX   11 AB2 THR A  182  SER A  185  5                                   4
HELIX   12 AB3 ARG A  186  ILE A  196  1                                  11
HELIX   13 AB4 PRO A  202  SER A  217  1                                  16
HELIX   14 AB5 GLY A  238  SER A  246  1                                   9
HELIX   15 AB6 PHE A  260  ASP A  264  5                                   5
HELIX   16 AB7 SER A  265  ARG A  283  1                                  19
HELIX   17 AB8 SER B   31  ARG B   36  5                                   6
HELIX   18 AB9 VAL B   38  LEU B   42  5                                   5
HELIX   19 AC1 ARG B   68  GLY B   84  1                                  17
HELIX   20 AC2 ASP B   95  TYR B  108  1                                  14
HELIX   21 AC3 TRP B  127  ASP B  132  5                                   6
HELIX   22 AC4 TYR B  133  ARG B  141  1                                   9
HELIX   23 AC5 GLN B  144  LEU B  150  1                                   7
HELIX   24 AC6 ASN B  153  LYS B  158  1                                   6
HELIX   25 AC7 LYS B  158  GLY B  163  1                                   6
HELIX   26 AC8 THR B  169  THR B  178  1                                  10
HELIX   27 AC9 THR B  182  SER B  185  5                                   4
HELIX   28 AD1 ARG B  186  ILE B  196  1                                  11
HELIX   29 AD2 PRO B  202  SER B  217  1                                  16
HELIX   30 AD3 GLY B  238  SER B  246  1                                   9
HELIX   31 AD4 PHE B  260  ASP B  264  5                                   5
HELIX   32 AD5 SER B  265  GLN B  284  1                                  20
HELIX   33 AD6 SER C   31  ARG C   36  5                                   6
HELIX   34 AD7 VAL C   38  LEU C   42  5                                   5
HELIX   35 AD8 ARG C   68  GLY C   84  1                                  17
HELIX   36 AD9 ASP C   95  TYR C  108  1                                  14
HELIX   37 AE1 THR C  126  ASP C  132  5                                   7
HELIX   38 AE2 TYR C  133  ARG C  141  1                                   9
HELIX   39 AE3 GLN C  144  LEU C  150  1                                   7
HELIX   40 AE4 ASN C  153  LYS C  158  1                                   6
HELIX   41 AE5 LYS C  158  GLY C  163  1                                   6
HELIX   42 AE6 THR C  169  THR C  178  1                                  10
HELIX   43 AE7 THR C  182  SER C  185  5                                   4
HELIX   44 AE8 ARG C  186  ILE C  196  1                                  11
HELIX   45 AE9 PRO C  202  SER C  217  1                                  16
HELIX   46 AF1 GLY C  238  ARG C  245  1                                   8
HELIX   47 AF2 PHE C  260  ASP C  264  5                                   5
HELIX   48 AF3 SER C  265  ARG C  283  1                                  19
HELIX   49 AF4 SER D   31  ARG D   36  5                                   6
HELIX   50 AF5 VAL D   38  LEU D   42  5                                   5
HELIX   51 AF6 ARG D   68  GLY D   84  1                                  17
HELIX   52 AF7 ASP D   95  TYR D  108  1                                  14
HELIX   53 AF8 TRP D  127  ASP D  132  5                                   6
HELIX   54 AF9 TYR D  133  ARG D  141  1                                   9
HELIX   55 AG1 GLN D  144  LEU D  150  1                                   7
HELIX   56 AG2 ASN D  153  LYS D  158  1                                   6
HELIX   57 AG3 LYS D  158  GLY D  163  1                                   6
HELIX   58 AG4 THR D  169  THR D  178  1                                  10
HELIX   59 AG5 THR D  182  SER D  185  5                                   4
HELIX   60 AG6 ARG D  186  ILE D  196  1                                  11
HELIX   61 AG7 PRO D  202  ARG D  218  1                                  17
HELIX   62 AG8 GLY D  238  SER D  246  1                                   9
HELIX   63 AG9 PHE D  260  ASP D  264  5                                   5
HELIX   64 AH1 SER D  265  GLU D  282  1                                  18
SHEET    1 AA1 8 LYS A   2  VAL A   6  0
SHEET    2 AA1 8 SER A   9  VAL A  16 -1  O  TYR A  13   N  LYS A   2
SHEET    3 AA1 8 ARG A  47  PRO A  51 -1  O  CYS A  48   N  VAL A  16
SHEET    4 AA1 8 PRO A  21  LEU A  25  1  N  ILE A  22   O  ARG A  47
SHEET    5 AA1 8 VAL A  89  HIS A  94  1  O  VAL A  92   N  VAL A  23
SHEET    6 AA1 8 ILE A 112  MET A 118  1  O  ALA A 116   N  LEU A  91
SHEET    7 AA1 8 LYS A 223  PRO A 230  1  O  ILE A 226   N  TYR A 117
SHEET    8 AA1 8 GLN A 250  GLY A 257  1  O  VAL A 253   N  VAL A 227
SHEET    1 AA2 8 LYS B   2  VAL B   6  0
SHEET    2 AA2 8 SER B   9  VAL B  16 -1  O  MET B  11   N  VAL B   4
SHEET    3 AA2 8 ARG B  47  PRO B  51 -1  O  CYS B  48   N  VAL B  16
SHEET    4 AA2 8 PRO B  21  LEU B  25  1  N  PHE B  24   O  LEU B  49
SHEET    5 AA2 8 VAL B  89  HIS B  94  1  O  VAL B  92   N  VAL B  23
SHEET    6 AA2 8 ILE B 112  MET B 118  1  O  ALA B 116   N  LEU B  91
SHEET    7 AA2 8 LYS B 223  PRO B 230  1  O  LEU B 224   N  TYR B 117
SHEET    8 AA2 8 GLN B 250  GLY B 257  1  O  VAL B 253   N  VAL B 227
SHEET    1 AA3 8 LYS C   2  VAL C   6  0
SHEET    2 AA3 8 SER C   9  VAL C  16 -1  O  MET C  11   N  VAL C   4
SHEET    3 AA3 8 ARG C  47  PRO C  51 -1  O  CYS C  48   N  VAL C  16
SHEET    4 AA3 8 PRO C  21  LEU C  25  1  N  PHE C  24   O  LEU C  49
SHEET    5 AA3 8 VAL C  89  HIS C  94  1  O  VAL C  90   N  VAL C  23
SHEET    6 AA3 8 ILE C 112  MET C 118  1  O  ALA C 116   N  LEU C  91
SHEET    7 AA3 8 LYS C 223  PRO C 230  1  O  ILE C 226   N  TYR C 117
SHEET    8 AA3 8 GLN C 250  GLY C 257  1  O  ARG C 251   N  LEU C 225
SHEET    1 AA4 8 LYS D   2  VAL D   6  0
SHEET    2 AA4 8 SER D   9  VAL D  16 -1  O  TYR D  13   N  LYS D   2
SHEET    3 AA4 8 ARG D  47  PRO D  51 -1  O  CYS D  48   N  VAL D  16
SHEET    4 AA4 8 PRO D  21  LEU D  25  1  N  ILE D  22   O  ARG D  47
SHEET    5 AA4 8 VAL D  89  HIS D  94  1  O  VAL D  92   N  VAL D  23
SHEET    6 AA4 8 ILE D 112  MET D 118  1  O  ALA D 116   N  LEU D  91
SHEET    7 AA4 8 LYS D 223  PRO D 230  1  O  ILE D 226   N  TYR D 117
SHEET    8 AA4 8 GLN D 250  GLY D 257  1  O  VAL D 253   N  VAL D 227
CISPEP   1 ASN A   28    PRO A   29          0        -3.04
CISPEP   2 GLU A  201    PRO A  202          0        -6.24
CISPEP   3 GLU A  229    PRO A  230          0         1.88
CISPEP   4 ASN B   28    PRO B   29          0        -7.25
CISPEP   5 GLU B  201    PRO B  202          0        -1.97
CISPEP   6 GLU B  229    PRO B  230          0         1.29
CISPEP   7 ASN C   28    PRO C   29          0       -10.83
CISPEP   8 GLU C  201    PRO C  202          0        -4.08
CISPEP   9 GLU C  229    PRO C  230          0         0.28
CISPEP  10 ASN D   28    PRO D   29          0        -1.44
CISPEP  11 GLU D  201    PRO D  202          0        -1.25
CISPEP  12 GLU D  229    PRO D  230          0         5.72
CRYST1   91.816   61.381  106.689  90.00 106.26  90.00 P 1 21 1      8
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.010891  0.000000  0.003176        0.00000
SCALE2      0.000000  0.016292  0.000000        0.00000
SCALE3      0.000000  0.000000  0.009763        0.00000
TER    2255      GLN A 284
TER    4506      GLN B 284
TER    6757      GLN C 284
TER    8991      ARG D 283
MASTER      357    0   18   64   32    0    0    6 9640    4  102   92
END