longtext: 8b6p-pdb

content
HEADER    HYDROLASE                               27-SEP-22   8B6P
TITLE     X-RAY STRUCTURE OF THE HALOALKANE DEHALOGENASE HALOTAG7 CIRCULAR
TITLE    2 PERMUTATED AT POSITIONS 154-156 (CPHALOTAG7_154-156)
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: HALOALKANE DEHALOGENASE;
COMPND   3 CHAIN: A, B;
COMPND   4 EC: 3.8.1.5;
COMPND   5 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: RHODOCOCCUS SP.;
SOURCE   3 ORGANISM_TAXID: 1831;
SOURCE   4 GENE: DHAA;
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 562
KEYWDS    HALOALKANE DEHALOGENASE, HALOTAG, HALOTAG7, SELF-LABELING PROTEIN,
KEYWDS   2 HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    M.TARNAWSKI,K.JOHNSSON,J.HIBLOT
REVDAT   1   11-OCT-23 8B6P    0
JRNL        AUTH   M.TARNAWSKI,K.JOHNSSON,J.HIBLOT
JRNL        TITL   X-RAY STRUCTURE OF THE HALOALKANE DEHALOGENASE HALOTAG7
JRNL        TITL 2 CIRCULAR PERMUTATED AT POSITIONS 154-156
JRNL        TITL 3 (CPHALOTAG7_154-156)
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   2
REMARK   2 RESOLUTION.    1.10 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX 1.19.2_4158
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : GEOSTD + MONOMER LIBRARY + CDL V1.2
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.10
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 42.79
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.380
REMARK   3   COMPLETENESS FOR RANGE        (%) : 95.4
REMARK   3   NUMBER OF REFLECTIONS             : 251832
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.138
REMARK   3   R VALUE            (WORKING SET) : 0.137
REMARK   3   FREE R VALUE                     : 0.149
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.000
REMARK   3   FREE R VALUE TEST SET COUNT      : 12591
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 42.7900 -  3.4200    0.97     8603   453  0.1581 0.1571
REMARK   3     2  3.4200 -  2.7100    0.98     8398   441  0.1707 0.1748
REMARK   3     3  2.7100 -  2.3700    0.97     8227   433  0.1623 0.1781
REMARK   3     4  2.3700 -  2.1500    0.97     8227   433  0.1487 0.1478
REMARK   3     5  2.1500 -  2.0000    0.97     8210   433  0.1428 0.1457
REMARK   3     6  2.0000 -  1.8800    0.98     8216   432  0.1428 0.1533
REMARK   3     7  1.8800 -  1.7900    0.98     8184   431  0.1389 0.1465
REMARK   3     8  1.7900 -  1.7100    0.96     8101   426  0.1269 0.1332
REMARK   3     9  1.7100 -  1.6400    0.97     8112   427  0.1226 0.1441
REMARK   3    10  1.6400 -  1.5900    0.97     8138   428  0.1140 0.1311
REMARK   3    11  1.5900 -  1.5400    0.97     8110   427  0.1126 0.1290
REMARK   3    12  1.5400 -  1.4900    0.97     8110   427  0.1113 0.1341
REMARK   3    13  1.4900 -  1.4500    0.97     8073   425  0.1143 0.1353
REMARK   3    14  1.4500 -  1.4200    0.97     8064   424  0.1174 0.1411
REMARK   3    15  1.4200 -  1.3900    0.96     7995   421  0.1136 0.1400
REMARK   3    16  1.3900 -  1.3600    0.96     8012   422  0.1155 0.1459
REMARK   3    17  1.3600 -  1.3300    0.96     8001   421  0.1135 0.1340
REMARK   3    18  1.3300 -  1.3000    0.96     7990   420  0.1094 0.1287
REMARK   3    19  1.3000 -  1.2800    0.96     8027   423  0.1121 0.1311
REMARK   3    20  1.2800 -  1.2600    0.96     7957   419  0.1101 0.1292
REMARK   3    21  1.2600 -  1.2400    0.96     7980   420  0.1105 0.1318
REMARK   3    22  1.2400 -  1.2200    0.95     7864   414  0.1119 0.1365
REMARK   3    23  1.2200 -  1.2000    0.95     7895   415  0.1122 0.1378
REMARK   3    24  1.2000 -  1.1800    0.95     7904   416  0.1136 0.1367
REMARK   3    25  1.1800 -  1.1700    0.95     7845   413  0.1105 0.1406
REMARK   3    26  1.1700 -  1.1500    0.94     7861   414  0.1126 0.1499
REMARK   3    27  1.1500 -  1.1400    0.94     7808   411  0.1088 0.1348
REMARK   3    28  1.1400 -  1.1300    0.93     7656   403  0.1115 0.1299
REMARK   3    29  1.1300 -  1.1100    0.88     7277   383  0.1150 0.1370
REMARK   3    30  1.1100 -  1.1000    0.77     6396   336  0.1251 0.1421
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL
REMARK   3   SOLVENT RADIUS     : 1.11
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.065
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 11.647
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 8.62
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 11.99
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :  0.010           4897
REMARK   3   ANGLE     :  1.165           6696
REMARK   3   CHIRALITY :  0.098            707
REMARK   3   PLANARITY :  0.013            883
REMARK   3   DIHEDRAL  :  5.611            644
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 8B6P COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 27-SEP-22.
REMARK 100 THE DEPOSITION ID IS D_1292125779.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 02-FEB-19
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : NULL
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : SLS
REMARK 200  BEAMLINE                       : X10SA
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.99986
REMARK 200  MONOCHROMATOR                  : SI(111)
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : PIXEL
REMARK 200  DETECTOR MANUFACTURER          : PSI PILATUS 6M
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200  DATA SCALING SOFTWARE          : XSCALE
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 251839
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.100
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 95.4
REMARK 200  DATA REDUNDANCY                : 4.300
REMARK 200  R MERGE                    (I) : 0.04800
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 17.6800
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.10
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.20
REMARK 200  COMPLETENESS FOR SHELL     (%) : 90.8
REMARK 200  DATA REDUNDANCY IN SHELL       : 4.10
REMARK 200  R MERGE FOR SHELL          (I) : 0.17400
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 8.490
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: 5Y2X
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 48.33
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.38
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.1 M BICINE PH 9.0, 1.6 M AMMONIUM
REMARK 280  SULFATE, VAPOR DIFFUSION, TEMPERATURE 293K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X+1/2,-Y,Z+1/2
REMARK 290       3555   -X,Y+1/2,-Z+1/2
REMARK 290       4555   X+1/2,-Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       34.43500
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       50.05500
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       47.33000
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       50.05500
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       34.43500
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       47.33000
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     GLY A   142
REMARK 465     GLY A   143
REMARK 465     THR A   144
REMARK 465     GLY A   145
REMARK 465     GLY A   146
REMARK 465     SER A   147
REMARK 465     GLY A   148
REMARK 465     GLY A   149
REMARK 465     THR A   150
REMARK 465     GLY A   151
REMARK 465     GLY A   152
REMARK 465     SER A   153
REMARK 465     GLY A   154
REMARK 465     GLY A   155
REMARK 465     SER A   156
REMARK 465     THR B   144
REMARK 465     GLY B   145
REMARK 465     GLY B   146
REMARK 465     SER B   147
REMARK 465     GLY B   148
REMARK 465     GLY B   149
REMARK 465     THR B   150
REMARK 465     GLY B   151
REMARK 465     GLY B   152
REMARK 465     SER B   153
REMARK 465     GLY B   154
REMARK 465     GLY B   155
REMARK 465     SER B   156
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    VAL A  91      -66.75   -130.80
REMARK 500    LEU A 117     -101.27   -117.50
REMARK 500    PRO A 162       49.62    -88.86
REMARK 500    GLU A 251      -95.76   -106.97
REMARK 500    ASP A 259     -136.63     60.13
REMARK 500    VAL B  91      -69.43   -130.47
REMARK 500    LEU B 117     -100.74   -117.69
REMARK 500    GLU B 251      -93.79   -108.80
REMARK 500    ASP B 259     -136.75     59.12
REMARK 500
REMARK 500 REMARK: NULL
REMARK 525
REMARK 525 SOLVENT
REMARK 525
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 525 NUMBER; I=INSERTION CODE):
REMARK 525
REMARK 525  M RES CSSEQI
REMARK 525    HOH B 848        DISTANCE =  6.39 ANGSTROMS
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 8B6N   RELATED DB: PDB
REMARK 900 RELATED ID: 8B6O   RELATED DB: PDB
REMARK 900 RELATED ID: 8B6Q   RELATED DB: PDB
DBREF  8B6P A    2   139  UNP    P0A3G3   DHAA_RHOSO     156    293
DBREF  8B6P A  157   307  UNP    P0A3G3   DHAA_RHOSO       4    154
DBREF  8B6P B    2   139  UNP    P0A3G3   DHAA_RHOSO     156    293
DBREF  8B6P B  157   307  UNP    P0A3G3   DHAA_RHOSO       4    154
SEQADV 8B6P GLY A   -1  UNP  P0A3G3              EXPRESSION TAG
SEQADV 8B6P GLY A    0  UNP  P0A3G3              EXPRESSION TAG
SEQADV 8B6P GLY A    1  UNP  P0A3G3              EXPRESSION TAG
SEQADV 8B6P LYS A    6  UNP  P0A3G3    GLU   160 CONFLICT
SEQADV 8B6P VAL A   13  UNP  P0A3G3    ALA   167 CONFLICT
SEQADV 8B6P THR A   18  UNP  P0A3G3    ALA   172 CONFLICT
SEQADV 8B6P MET A   21  UNP  P0A3G3    LYS   175 CONFLICT
SEQADV 8B6P GLY A   22  UNP  P0A3G3    CYS   176 CONFLICT
SEQADV 8B6P ASN A   41  UNP  P0A3G3    LYS   195 CONFLICT
SEQADV 8B6P GLU A   70  UNP  P0A3G3    ALA   224 CONFLICT
SEQADV 8B6P ASP A   73  UNP  P0A3G3    ASN   227 CONFLICT
SEQADV 8B6P LYS A  103  UNP  P0A3G3    GLU   257 CONFLICT
SEQADV 8B6P ALA A  110  UNP  P0A3G3    THR   264 CONFLICT
SEQADV 8B6P ASN A  118  UNP  P0A3G3    HIS   272 CONFLICT
SEQADV 8B6P LEU A  119  UNP  P0A3G3    TYR   273 CONFLICT
SEQADV 8B6P SER A  137  UNP  P0A3G3    PRO   291 CONFLICT
SEQADV 8B6P THR A  138  UNP  P0A3G3    ALA   292 CONFLICT
SEQADV 8B6P GLU A  140  UNP  P0A3G3              LINKER
SEQADV 8B6P ILE A  141  UNP  P0A3G3              LINKER
SEQADV 8B6P GLY A  142  UNP  P0A3G3              LINKER
SEQADV 8B6P GLY A  143  UNP  P0A3G3              LINKER
SEQADV 8B6P THR A  144  UNP  P0A3G3              LINKER
SEQADV 8B6P GLY A  145  UNP  P0A3G3              LINKER
SEQADV 8B6P GLY A  146  UNP  P0A3G3              LINKER
SEQADV 8B6P SER A  147  UNP  P0A3G3              LINKER
SEQADV 8B6P GLY A  148  UNP  P0A3G3              LINKER
SEQADV 8B6P GLY A  149  UNP  P0A3G3              LINKER
SEQADV 8B6P THR A  150  UNP  P0A3G3              LINKER
SEQADV 8B6P GLY A  151  UNP  P0A3G3              LINKER
SEQADV 8B6P GLY A  152  UNP  P0A3G3              LINKER
SEQADV 8B6P SER A  153  UNP  P0A3G3              LINKER
SEQADV 8B6P GLY A  154  UNP  P0A3G3              LINKER
SEQADV 8B6P GLY A  155  UNP  P0A3G3              LINKER
SEQADV 8B6P SER A  156  UNP  P0A3G3              LINKER
SEQADV 8B6P VAL A  200  UNP  P0A3G3    LEU    47 CONFLICT
SEQADV 8B6P THR A  211  UNP  P0A3G3    SER    58 CONFLICT
SEQADV 8B6P GLY A  231  UNP  P0A3G3    ASP    78 CONFLICT
SEQADV 8B6P PHE A  240  UNP  P0A3G3    TYR    87 CONFLICT
SEQADV 8B6P MET A  241  UNP  P0A3G3    LEU    88 CONFLICT
SEQADV 8B6P PHE A  281  UNP  P0A3G3    CYS   128 CONFLICT
SEQADV 8B6P GLY B   -1  UNP  P0A3G3              EXPRESSION TAG
SEQADV 8B6P GLY B    0  UNP  P0A3G3              EXPRESSION TAG
SEQADV 8B6P GLY B    1  UNP  P0A3G3              EXPRESSION TAG
SEQADV 8B6P LYS B    6  UNP  P0A3G3    GLU   160 CONFLICT
SEQADV 8B6P VAL B   13  UNP  P0A3G3    ALA   167 CONFLICT
SEQADV 8B6P THR B   18  UNP  P0A3G3    ALA   172 CONFLICT
SEQADV 8B6P MET B   21  UNP  P0A3G3    LYS   175 CONFLICT
SEQADV 8B6P GLY B   22  UNP  P0A3G3    CYS   176 CONFLICT
SEQADV 8B6P ASN B   41  UNP  P0A3G3    LYS   195 CONFLICT
SEQADV 8B6P GLU B   70  UNP  P0A3G3    ALA   224 CONFLICT
SEQADV 8B6P ASP B   73  UNP  P0A3G3    ASN   227 CONFLICT
SEQADV 8B6P LYS B  103  UNP  P0A3G3    GLU   257 CONFLICT
SEQADV 8B6P ALA B  110  UNP  P0A3G3    THR   264 CONFLICT
SEQADV 8B6P ASN B  118  UNP  P0A3G3    HIS   272 CONFLICT
SEQADV 8B6P LEU B  119  UNP  P0A3G3    TYR   273 CONFLICT
SEQADV 8B6P SER B  137  UNP  P0A3G3    PRO   291 CONFLICT
SEQADV 8B6P THR B  138  UNP  P0A3G3    ALA   292 CONFLICT
SEQADV 8B6P GLU B  140  UNP  P0A3G3              LINKER
SEQADV 8B6P ILE B  141  UNP  P0A3G3              LINKER
SEQADV 8B6P GLY B  142  UNP  P0A3G3              LINKER
SEQADV 8B6P GLY B  143  UNP  P0A3G3              LINKER
SEQADV 8B6P THR B  144  UNP  P0A3G3              LINKER
SEQADV 8B6P GLY B  145  UNP  P0A3G3              LINKER
SEQADV 8B6P GLY B  146  UNP  P0A3G3              LINKER
SEQADV 8B6P SER B  147  UNP  P0A3G3              LINKER
SEQADV 8B6P GLY B  148  UNP  P0A3G3              LINKER
SEQADV 8B6P GLY B  149  UNP  P0A3G3              LINKER
SEQADV 8B6P THR B  150  UNP  P0A3G3              LINKER
SEQADV 8B6P GLY B  151  UNP  P0A3G3              LINKER
SEQADV 8B6P GLY B  152  UNP  P0A3G3              LINKER
SEQADV 8B6P SER B  153  UNP  P0A3G3              LINKER
SEQADV 8B6P GLY B  154  UNP  P0A3G3              LINKER
SEQADV 8B6P GLY B  155  UNP  P0A3G3              LINKER
SEQADV 8B6P SER B  156  UNP  P0A3G3              LINKER
SEQADV 8B6P VAL B  200  UNP  P0A3G3    LEU    47 CONFLICT
SEQADV 8B6P THR B  211  UNP  P0A3G3    SER    58 CONFLICT
SEQADV 8B6P GLY B  231  UNP  P0A3G3    ASP    78 CONFLICT
SEQADV 8B6P PHE B  240  UNP  P0A3G3    TYR    87 CONFLICT
SEQADV 8B6P MET B  241  UNP  P0A3G3    LEU    88 CONFLICT
SEQADV 8B6P PHE B  281  UNP  P0A3G3    CYS   128 CONFLICT
SEQRES   1 A  309  GLY GLY GLY ASP VAL GLY ARG LYS LEU ILE ILE ASP GLN
SEQRES   2 A  309  ASN VAL PHE ILE GLU GLY THR LEU PRO MET GLY VAL VAL
SEQRES   3 A  309  ARG PRO LEU THR GLU VAL GLU MET ASP HIS TYR ARG GLU
SEQRES   4 A  309  PRO PHE LEU ASN PRO VAL ASP ARG GLU PRO LEU TRP ARG
SEQRES   5 A  309  PHE PRO ASN GLU LEU PRO ILE ALA GLY GLU PRO ALA ASN
SEQRES   6 A  309  ILE VAL ALA LEU VAL GLU GLU TYR MET ASP TRP LEU HIS
SEQRES   7 A  309  GLN SER PRO VAL PRO LYS LEU LEU PHE TRP GLY THR PRO
SEQRES   8 A  309  GLY VAL LEU ILE PRO PRO ALA GLU ALA ALA ARG LEU ALA
SEQRES   9 A  309  LYS SER LEU PRO ASN CYS LYS ALA VAL ASP ILE GLY PRO
SEQRES  10 A  309  GLY LEU ASN LEU LEU GLN GLU ASP ASN PRO ASP LEU ILE
SEQRES  11 A  309  GLY SER GLU ILE ALA ARG TRP LEU SER THR LEU GLU ILE
SEQRES  12 A  309  GLY GLY THR GLY GLY SER GLY GLY THR GLY GLY SER GLY
SEQRES  13 A  309  GLY SER ILE GLY THR GLY PHE PRO PHE ASP PRO HIS TYR
SEQRES  14 A  309  VAL GLU VAL LEU GLY GLU ARG MET HIS TYR VAL ASP VAL
SEQRES  15 A  309  GLY PRO ARG ASP GLY THR PRO VAL LEU PHE LEU HIS GLY
SEQRES  16 A  309  ASN PRO THR SER SER TYR VAL TRP ARG ASN ILE ILE PRO
SEQRES  17 A  309  HIS VAL ALA PRO THR HIS ARG CYS ILE ALA PRO ASP LEU
SEQRES  18 A  309  ILE GLY MET GLY LYS SER ASP LYS PRO ASP LEU GLY TYR
SEQRES  19 A  309  PHE PHE ASP ASP HIS VAL ARG PHE MET ASP ALA PHE ILE
SEQRES  20 A  309  GLU ALA LEU GLY LEU GLU GLU VAL VAL LEU VAL ILE HIS
SEQRES  21 A  309  ASP TRP GLY SER ALA LEU GLY PHE HIS TRP ALA LYS ARG
SEQRES  22 A  309  ASN PRO GLU ARG VAL LYS GLY ILE ALA PHE MET GLU PHE
SEQRES  23 A  309  ILE ARG PRO ILE PRO THR TRP ASP GLU TRP PRO GLU PHE
SEQRES  24 A  309  ALA ARG GLU THR PHE GLN ALA PHE ARG THR
SEQRES   1 B  309  GLY GLY GLY ASP VAL GLY ARG LYS LEU ILE ILE ASP GLN
SEQRES   2 B  309  ASN VAL PHE ILE GLU GLY THR LEU PRO MET GLY VAL VAL
SEQRES   3 B  309  ARG PRO LEU THR GLU VAL GLU MET ASP HIS TYR ARG GLU
SEQRES   4 B  309  PRO PHE LEU ASN PRO VAL ASP ARG GLU PRO LEU TRP ARG
SEQRES   5 B  309  PHE PRO ASN GLU LEU PRO ILE ALA GLY GLU PRO ALA ASN
SEQRES   6 B  309  ILE VAL ALA LEU VAL GLU GLU TYR MET ASP TRP LEU HIS
SEQRES   7 B  309  GLN SER PRO VAL PRO LYS LEU LEU PHE TRP GLY THR PRO
SEQRES   8 B  309  GLY VAL LEU ILE PRO PRO ALA GLU ALA ALA ARG LEU ALA
SEQRES   9 B  309  LYS SER LEU PRO ASN CYS LYS ALA VAL ASP ILE GLY PRO
SEQRES  10 B  309  GLY LEU ASN LEU LEU GLN GLU ASP ASN PRO ASP LEU ILE
SEQRES  11 B  309  GLY SER GLU ILE ALA ARG TRP LEU SER THR LEU GLU ILE
SEQRES  12 B  309  GLY GLY THR GLY GLY SER GLY GLY THR GLY GLY SER GLY
SEQRES  13 B  309  GLY SER ILE GLY THR GLY PHE PRO PHE ASP PRO HIS TYR
SEQRES  14 B  309  VAL GLU VAL LEU GLY GLU ARG MET HIS TYR VAL ASP VAL
SEQRES  15 B  309  GLY PRO ARG ASP GLY THR PRO VAL LEU PHE LEU HIS GLY
SEQRES  16 B  309  ASN PRO THR SER SER TYR VAL TRP ARG ASN ILE ILE PRO
SEQRES  17 B  309  HIS VAL ALA PRO THR HIS ARG CYS ILE ALA PRO ASP LEU
SEQRES  18 B  309  ILE GLY MET GLY LYS SER ASP LYS PRO ASP LEU GLY TYR
SEQRES  19 B  309  PHE PHE ASP ASP HIS VAL ARG PHE MET ASP ALA PHE ILE
SEQRES  20 B  309  GLU ALA LEU GLY LEU GLU GLU VAL VAL LEU VAL ILE HIS
SEQRES  21 B  309  ASP TRP GLY SER ALA LEU GLY PHE HIS TRP ALA LYS ARG
SEQRES  22 B  309  ASN PRO GLU ARG VAL LYS GLY ILE ALA PHE MET GLU PHE
SEQRES  23 B  309  ILE ARG PRO ILE PRO THR TRP ASP GLU TRP PRO GLU PHE
SEQRES  24 B  309  ALA ARG GLU THR PHE GLN ALA PHE ARG THR
HET     CL  A 400       1
HET     CL  B 400       1
HETNAM      CL CHLORIDE ION
FORMUL   3   CL    2(CL 1-)
FORMUL   5  HOH   *680(H2 O)
HELIX    1 AA1 GLY A    1  ILE A    9  1                                   9
HELIX    2 AA2 ASN A   12  GLY A   17  1                                   6
HELIX    3 AA3 GLY A   17  GLY A   22  1                                   6
HELIX    4 AA4 THR A   28  GLU A   37  1                                  10
HELIX    5 AA5 PRO A   38  LEU A   40  5                                   3
HELIX    6 AA6 ASN A   41  ASP A   44  5                                   4
HELIX    7 AA7 ARG A   45  LEU A   55  1                                  11
HELIX    8 AA8 PRO A   61  SER A   78  1                                  18
HELIX    9 AA9 PRO A   94  LEU A  105  1                                  12
HELIX   10 AB1 LEU A  119  ASN A  124  1                                   6
HELIX   11 AB2 ASN A  124  LEU A  139  1                                  16
HELIX   12 AB3 SER A  197  ARG A  202  5                                   6
HELIX   13 AB4 ILE A  204  ALA A  209  1                                   6
HELIX   14 AB5 PHE A  233  LEU A  248  1                                  16
HELIX   15 AB6 ASP A  259  ASN A  272  1                                  14
HELIX   16 AB7 THR A  290  TRP A  294  5                                   5
HELIX   17 AB8 PRO A  295  ARG A  306  1                                  12
HELIX   18 AB9 GLY B    1  ILE B    9  1                                   9
HELIX   19 AC1 ASN B   12  GLY B   17  1                                   6
HELIX   20 AC2 GLY B   17  GLY B   22  1                                   6
HELIX   21 AC3 THR B   28  GLU B   37  1                                  10
HELIX   22 AC4 PRO B   38  LEU B   40  5                                   3
HELIX   23 AC5 ASN B   41  ASP B   44  5                                   4
HELIX   24 AC6 ARG B   45  LEU B   55  1                                  11
HELIX   25 AC7 PRO B   61  SER B   78  1                                  18
HELIX   26 AC8 PRO B   94  LEU B  105  1                                  12
HELIX   27 AC9 LEU B  119  ASN B  124  1                                   6
HELIX   28 AD1 ASN B  124  SER B  137  1                                  14
HELIX   29 AD2 SER B  197  ARG B  202  5                                   6
HELIX   30 AD3 ILE B  204  ALA B  209  1                                   6
HELIX   31 AD4 PHE B  233  LEU B  248  1                                  16
HELIX   32 AD5 ASP B  259  ASN B  272  1                                  14
HELIX   33 AD6 THR B  290  TRP B  294  5                                   5
HELIX   34 AD7 PRO B  295  PHE B  297  5                                   3
HELIX   35 AD8 ALA B  298  ARG B  306  1                                   9
SHEET    1 AA1 8 CYS A 108  GLY A 116  0
SHEET    2 AA1 8 LYS A  82  PRO A  89  1  N  TRP A  86   O  ILE A 113
SHEET    3 AA1 8 VAL A 276  MET A 282  1  O  PHE A 281   N  LEU A  83
SHEET    4 AA1 8 VAL A 253  HIS A 258  1  N  LEU A 255   O  ALA A 280
SHEET    5 AA1 8 VAL A 188  LEU A 191  1  N  LEU A 189   O  VAL A 254
SHEET    6 AA1 8 CYS A 214  PRO A 217  1  O  ILE A 215   N  PHE A 190
SHEET    7 AA1 8 GLU A 173  VAL A 180 -1  N  VAL A 180   O  CYS A 214
SHEET    8 AA1 8 HIS A 166  VAL A 170 -1  N  VAL A 170   O  GLU A 173
SHEET    1 AA2 8 CYS B 108  GLY B 116  0
SHEET    2 AA2 8 LYS B  82  PRO B  89  1  N  LEU B  84   O  VAL B 111
SHEET    3 AA2 8 VAL B 276  MET B 282  1  O  PHE B 281   N  LEU B  83
SHEET    4 AA2 8 VAL B 253  HIS B 258  1  N  LEU B 255   O  ALA B 280
SHEET    5 AA2 8 VAL B 188  LEU B 191  1  N  LEU B 189   O  VAL B 254
SHEET    6 AA2 8 CYS B 214  PRO B 217  1  O  ILE B 215   N  PHE B 190
SHEET    7 AA2 8 GLU B 173  VAL B 180 -1  N  VAL B 180   O  CYS B 214
SHEET    8 AA2 8 HIS B 166  VAL B 170 -1  N  VAL B 170   O  GLU B 173
CISPEP   1 GLU A   60    PRO A   61          0        -5.76
CISPEP   2 THR A   88    PRO A   89          0         4.13
CISPEP   3 ASN A  194    PRO A  195          0         5.76
CISPEP   4 GLU B   60    PRO B   61          0        -6.43
CISPEP   5 THR B   88    PRO B   89          0         3.82
CISPEP   6 ASN B  194    PRO B  195          0         5.43
CRYST1   68.870   94.660  100.110  90.00  90.00  90.00 P 21 21 21    8
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.014520  0.000000  0.000000        0.00000
SCALE2      0.000000  0.010564  0.000000        0.00000
SCALE3      0.000000  0.000000  0.009989        0.00000
TER    2362      THR A 307
TER    4738      THR B 307
MASTER      302    0    2   35   16    0    0    6 5392    2    0   48
END