longtext: 8clt-pdb

content
HEADER    HYDROLASE                               17-FEB-23   8CLT
TITLE     ZEARALENONE LACTONASE OF RHODOCOCCUS ERYTHROPOLIS
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: ZEARALENONE LACTONASE;
COMPND   3 CHAIN: A, B;
COMPND   4 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: RHODOCOCCUS ERYTHROPOLIS;
SOURCE   3 ORGANISM_TAXID: 1833;
SOURCE   4 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3);
SOURCE   5 EXPRESSION_SYSTEM_TAXID: 469008
KEYWDS    ZEARALENONE, MYCOTOXIN, LACTONASE, CARBOXYLESTERASE, ESTERASE,
KEYWDS   2 HYDROLASE, BIODEGRADATION, RHODOCOCCUS ERYTHROPOLIS
EXPDTA    X-RAY DIFFRACTION
AUTHOR    D.PUEHRINGER,G.MLYNEK
REVDAT   1   21-FEB-24 8CLT    0
JRNL        AUTH   S.FRUHAUF,D.PUEHRINGER,M.THAMHESL,P.FAJTL,E.KUNZ-VEKIRO,
JRNL        AUTH 2 A.HOEBARTNER-GUSSL,J.PANHOELZL,K.PREM,V.KLINGENBRUNNER,
JRNL        AUTH 3 G.SCHATZMAYR,G.ADAM,J.DAMBORSKY,K.DJINOVIC-CARUGO,Z.PROKOP,
JRNL        AUTH 4 W.D.MOLL
JRNL        TITL   BACTERIAL LACTONASES ZENA WITH NONCANONICAL STRUCTURAL
JRNL        TITL 2 FEATURES HYDROLYSE THE MYCOTOXIN ZEARALENONE
JRNL        REF    ACS CATALYSIS                              2024
JRNL        REFN                   ESSN 2155-5435
JRNL        DOI    10.1021/ACSCATAL.4C00271
REMARK   2
REMARK   2 RESOLUTION.    1.46 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX 1.20.1-4487
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : ML
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.46
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 47.53
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.330
REMARK   3   COMPLETENESS FOR RANGE        (%) : 93.0
REMARK   3   NUMBER OF REFLECTIONS             : 109245
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.165
REMARK   3   R VALUE            (WORKING SET) : 0.164
REMARK   3   FREE R VALUE                     : 0.199
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 1.730
REMARK   3   FREE R VALUE TEST SET COUNT      : 1895
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 47.5300 -  3.5200    1.00     8588   153  0.1447 0.1687
REMARK   3     2  3.5200 -  2.7900    1.00     8319   154  0.1373 0.1579
REMARK   3     3  2.7900 -  2.4400    1.00     8298   149  0.1354 0.1753
REMARK   3     4  2.4400 -  2.2200    1.00     8251   138  0.1365 0.1701
REMARK   3     5  2.2200 -  2.0600    1.00     8260   153  0.1375 0.2034
REMARK   3     6  2.0600 -  1.9400    1.00     8191   144  0.1493 0.2212
REMARK   3     7  1.9400 -  1.8400    1.00     8229   140  0.1861 0.2434
REMARK   3     8  1.8400 -  1.7600    1.00     8181   146  0.2383 0.2617
REMARK   3     9  1.7600 -  1.6900    1.00     8196   140  0.2492 0.3203
REMARK   3    10  1.6900 -  1.6300    1.00     8182   141  0.2746 0.3065
REMARK   3    11  1.6300 -  1.5800    1.00     8155   149  0.3055 0.3671
REMARK   3    12  1.5800 -  1.5400    0.95     7786   141  0.3668 0.3878
REMARK   3    13  1.5400 -  1.5000    0.79     6466   105  0.4362 0.4605
REMARK   3    14  1.5000 -  1.4600    0.28     2248    42  0.5025 0.4459
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL
REMARK   3   SOLVENT RADIUS     : 1.11
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.240
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 27.980
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 22.58
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :  0.009           5003
REMARK   3   ANGLE     :  1.014           6813
REMARK   3   CHIRALITY :  0.081            717
REMARK   3   PLANARITY :  0.017            895
REMARK   3   DIHEDRAL  :  7.486            682
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 8CLT COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 17-FEB-23.
REMARK 100 THE DEPOSITION ID IS D_1292126826.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 26-JUL-18
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 5.5
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : ESRF
REMARK 200  BEAMLINE                       : ID29
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.976250
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : PIXEL
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS PILATUS 6M
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200  DATA SCALING SOFTWARE          : XDS
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 114638
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.460
REMARK 200  RESOLUTION RANGE LOW       (A) : 47.530
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 93.0
REMARK 200  DATA REDUNDANCY                : 6.000
REMARK 200  R MERGE                    (I) : 0.10140
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 10.2000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.46
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.51
REMARK 200  COMPLETENESS FOR SHELL     (%) : 39.3
REMARK 200  DATA REDUNDANCY IN SHELL       : 0.18
REMARK 200  R MERGE FOR SHELL          (I) : 4.67700
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 0.180
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 47.41
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.34
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.2 M NACL, 0.1 M BIS-TRIS 5.5 PH, 25%
REMARK 280  W/V PEG 3350, PH 5.5, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE
REMARK 280  295.15K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: C 2 2 21
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,-Y,Z+1/2
REMARK 290       3555   -X,Y,-Z+1/2
REMARK 290       4555   X,-Y,-Z
REMARK 290       5555   X+1/2,Y+1/2,Z
REMARK 290       6555   -X+1/2,-Y+1/2,Z+1/2
REMARK 290       7555   -X+1/2,Y+1/2,-Z+1/2
REMARK 290       8555   X+1/2,-Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       86.17800
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       86.17800
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   5  1.000000  0.000000  0.000000       32.23350
REMARK 290   SMTRY2   5  0.000000  1.000000  0.000000       60.90150
REMARK 290   SMTRY3   5  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   6 -1.000000  0.000000  0.000000       32.23350
REMARK 290   SMTRY2   6  0.000000 -1.000000  0.000000       60.90150
REMARK 290   SMTRY3   6  0.000000  0.000000  1.000000       86.17800
REMARK 290   SMTRY1   7 -1.000000  0.000000  0.000000       32.23350
REMARK 290   SMTRY2   7  0.000000  1.000000  0.000000       60.90150
REMARK 290   SMTRY3   7  0.000000  0.000000 -1.000000       86.17800
REMARK 290   SMTRY1   8  1.000000  0.000000  0.000000       32.23350
REMARK 290   SMTRY2   8  0.000000 -1.000000  0.000000       60.90150
REMARK 290   SMTRY3   8  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 375
REMARK 375 SPECIAL POSITION
REMARK 375 THE FOLLOWING ATOMS ARE FOUND TO BE WITHIN 0.15 ANGSTROMS
REMARK 375 OF A SYMMETRY RELATED ATOM AND ARE ASSUMED TO BE ON SPECIAL
REMARK 375 POSITIONS.
REMARK 375
REMARK 375 ATOM RES CSSEQI
REMARK 375      HOH A 761  LIES ON A SPECIAL POSITION.
REMARK 375      HOH B 680  LIES ON A SPECIAL POSITION.
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A     1
REMARK 465     ALA A     2
REMARK 465     GLU A     3
REMARK 465     GLU A     4
REMARK 465     GLY A     5
REMARK 465     THR A     6
REMARK 465     ARG A     7
REMARK 465     SER A     8
REMARK 465     GLU A     9
REMARK 465     ALA A    10
REMARK 465     ALA A    11
REMARK 465     ASP A    12
REMARK 465     ALA A    13
REMARK 465     ALA A    14
REMARK 465     THR A    15
REMARK 465     GLN A    16
REMARK 465     ALA A    17
REMARK 465     ARG A    18
REMARK 465     GLN A    19
REMARK 465     LEU A    20
REMARK 465     PRO A    21
REMARK 465     ASP A    22
REMARK 465     SER A    23
REMARK 465     ARG A    24
REMARK 465     ASN A    25
REMARK 465     MET B     1
REMARK 465     ALA B     2
REMARK 465     GLU B     3
REMARK 465     GLU B     4
REMARK 465     GLY B     5
REMARK 465     THR B     6
REMARK 465     ARG B     7
REMARK 465     SER B     8
REMARK 465     GLU B     9
REMARK 465     ALA B    10
REMARK 465     ALA B    11
REMARK 465     ASP B    12
REMARK 465     ALA B    13
REMARK 465     ALA B    14
REMARK 465     THR B    15
REMARK 465     GLN B    16
REMARK 465     ALA B    17
REMARK 465     ARG B    18
REMARK 465     GLN B    19
REMARK 465     LEU B    20
REMARK 465     PRO B    21
REMARK 465     ASP B    22
REMARK 465     ASN B   327
REMARK 465     ASP B   328
REMARK 465     HIS B   329
REMARK 465     HIS B   330
REMARK 465     HIS B   331
REMARK 465     HIS B   332
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     SER B  23    OG
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    THR A  64       -2.06     76.06
REMARK 500    SER A 128     -125.15     62.75
REMARK 500    PHE A 157      -53.05     73.63
REMARK 500    ALA A 172     -104.28   -137.92
REMARK 500    HIS A 259     -150.23    -91.86
REMARK 500    ASN B  25       41.17   -143.32
REMARK 500    THR B  64       -4.45     77.63
REMARK 500    SER B 128     -123.21     58.98
REMARK 500    PHE B 157      -53.21     71.09
REMARK 500    ALA B 172     -101.72   -143.92
REMARK 500    HIS B 259     -147.07    -92.58
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: PLANAR GROUPS
REMARK 500
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS
REMARK 500 AN RMSD GREATER THAN THIS VALUE
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500  M RES CSSEQI        RMS     TYPE
REMARK 500    ARG A  35         0.19    SIDE CHAIN
REMARK 500    ARG B  35         0.09    SIDE CHAIN
REMARK 500
REMARK 500 REMARK: NULL
DBREF  8CLT A    1   332  PDB    8CLT     8CLT             1    332
DBREF  8CLT B    1   332  PDB    8CLT     8CLT             1    332
SEQRES   1 A  332  MET ALA GLU GLU GLY THR ARG SER GLU ALA ALA ASP ALA
SEQRES   2 A  332  ALA THR GLN ALA ARG GLN LEU PRO ASP SER ARG ASN ILE
SEQRES   3 A  332  PHE VAL SER HIS ARG PHE PRO GLU ARG GLN VAL ASP LEU
SEQRES   4 A  332  GLY GLU VAL VAL MET ASN PHE ALA GLU ALA GLY SER PRO
SEQRES   5 A  332  ASP ASN PRO ALA LEU LEU LEU LEU PRO GLU GLN THR GLY
SEQRES   6 A  332  SER TRP TRP SER TYR GLU PRO VAL MET GLY LEU LEU ALA
SEQRES   7 A  332  GLU ASN PHE HIS VAL PHE ALA VAL ASP ILE ARG GLY GLN
SEQRES   8 A  332  GLY ARG SER THR TRP THR PRO ARG ARG TYR SER LEU ASP
SEQRES   9 A  332  ASN PHE GLY ASN ASP LEU VAL ARG PHE ILE ALA LEU VAL
SEQRES  10 A  332  ILE LYS ARG PRO VAL VAL VAL ALA GLY ASN SER SER GLY
SEQRES  11 A  332  GLY LEU LEU ALA ALA TRP LEU SER ALA TYR ALA MET PRO
SEQRES  12 A  332  GLY GLN ILE ARG ALA ALA LEU CYS GLU ASP ALA PRO PHE
SEQRES  13 A  332  PHE ALA SER GLU LEU VAL PRO ALA TYR GLY HIS SER VAL
SEQRES  14 A  332  LEU GLN ALA ALA GLY PRO ALA PHE GLU LEU TYR ARG ASP
SEQRES  15 A  332  PHE LEU GLY ASP GLN TRP SER ILE GLY ASP TRP LYS GLY
SEQRES  16 A  332  PHE VAL GLU ALA ALA LYS ALA SER PRO ALA LYS ALA MET
SEQRES  17 A  332  GLN LEU PHE PRO THR PRO ASP GLU ALA PRO GLN ASN LEU
SEQRES  18 A  332  LYS GLU TYR ASP PRO GLU TRP GLY ARG ALA PHE PHE GLU
SEQRES  19 A  332  GLY THR VAL ALA LEU HIS CYS PRO HIS ASP ARG MET LEU
SEQRES  20 A  332  SER GLN VAL LYS THR PRO ILE LEU ILE THR HIS HIS ALA
SEQRES  21 A  332  ARG THR ILE ASP PRO GLU THR GLY GLU LEU LEU GLY ALA
SEQRES  22 A  332  LEU SER ASP LEU GLN ALA GLU HIS ALA GLN ASP ILE ILE
SEQRES  23 A  332  ARG SER ALA GLY VAL ARG VAL ASP TYR GLN SER HIS PRO
SEQRES  24 A  332  ASP ALA LEU HIS MET MET HIS LEU PHE ASP PRO ALA ARG
SEQRES  25 A  332  TYR ALA GLU ILE LEU THR SER TRP SER ALA THR LEU PRO
SEQRES  26 A  332  ALA ASN ASP HIS HIS HIS HIS
SEQRES   1 B  332  MET ALA GLU GLU GLY THR ARG SER GLU ALA ALA ASP ALA
SEQRES   2 B  332  ALA THR GLN ALA ARG GLN LEU PRO ASP SER ARG ASN ILE
SEQRES   3 B  332  PHE VAL SER HIS ARG PHE PRO GLU ARG GLN VAL ASP LEU
SEQRES   4 B  332  GLY GLU VAL VAL MET ASN PHE ALA GLU ALA GLY SER PRO
SEQRES   5 B  332  ASP ASN PRO ALA LEU LEU LEU LEU PRO GLU GLN THR GLY
SEQRES   6 B  332  SER TRP TRP SER TYR GLU PRO VAL MET GLY LEU LEU ALA
SEQRES   7 B  332  GLU ASN PHE HIS VAL PHE ALA VAL ASP ILE ARG GLY GLN
SEQRES   8 B  332  GLY ARG SER THR TRP THR PRO ARG ARG TYR SER LEU ASP
SEQRES   9 B  332  ASN PHE GLY ASN ASP LEU VAL ARG PHE ILE ALA LEU VAL
SEQRES  10 B  332  ILE LYS ARG PRO VAL VAL VAL ALA GLY ASN SER SER GLY
SEQRES  11 B  332  GLY LEU LEU ALA ALA TRP LEU SER ALA TYR ALA MET PRO
SEQRES  12 B  332  GLY GLN ILE ARG ALA ALA LEU CYS GLU ASP ALA PRO PHE
SEQRES  13 B  332  PHE ALA SER GLU LEU VAL PRO ALA TYR GLY HIS SER VAL
SEQRES  14 B  332  LEU GLN ALA ALA GLY PRO ALA PHE GLU LEU TYR ARG ASP
SEQRES  15 B  332  PHE LEU GLY ASP GLN TRP SER ILE GLY ASP TRP LYS GLY
SEQRES  16 B  332  PHE VAL GLU ALA ALA LYS ALA SER PRO ALA LYS ALA MET
SEQRES  17 B  332  GLN LEU PHE PRO THR PRO ASP GLU ALA PRO GLN ASN LEU
SEQRES  18 B  332  LYS GLU TYR ASP PRO GLU TRP GLY ARG ALA PHE PHE GLU
SEQRES  19 B  332  GLY THR VAL ALA LEU HIS CYS PRO HIS ASP ARG MET LEU
SEQRES  20 B  332  SER GLN VAL LYS THR PRO ILE LEU ILE THR HIS HIS ALA
SEQRES  21 B  332  ARG THR ILE ASP PRO GLU THR GLY GLU LEU LEU GLY ALA
SEQRES  22 B  332  LEU SER ASP LEU GLN ALA GLU HIS ALA GLN ASP ILE ILE
SEQRES  23 B  332  ARG SER ALA GLY VAL ARG VAL ASP TYR GLN SER HIS PRO
SEQRES  24 B  332  ASP ALA LEU HIS MET MET HIS LEU PHE ASP PRO ALA ARG
SEQRES  25 B  332  TYR ALA GLU ILE LEU THR SER TRP SER ALA THR LEU PRO
SEQRES  26 B  332  ALA ASN ASP HIS HIS HIS HIS
HET    GOL  A 401      12
HET    GOL  A 402      14
HET    GOL  A 403      13
HET    GOL  A 404      14
HET    GOL  A 405      13
HET    GOL  B 401      14
HET    GOL  B 402      14
HET    GOL  B 403      13
HET    GOL  B 404      14
HET    GOL  B 405      12
HETNAM     GOL GLYCEROL
HETSYN     GOL GLYCERIN; PROPANE-1,2,3-TRIOL
FORMUL   3  GOL    10(C3 H8 O3)
FORMUL  13  HOH   *569(H2 O)
HELIX    1 AA1 SER A   66  SER A   69  5                                   4
HELIX    2 AA2 TYR A   70  GLU A   79  1                                  10
HELIX    3 AA3 SER A  102  VAL A  117  1                                  16
HELIX    4 AA4 SER A  128  ALA A  141  1                                  14
HELIX    5 AA5 SER A  168  ALA A  172  5                                   5
HELIX    6 AA6 ALA A  173  LEU A  184  1                                  12
HELIX    7 AA7 GLY A  185  SER A  189  5                                   5
HELIX    8 AA8 ASP A  192  SER A  203  1                                  12
HELIX    9 AA9 ALA A  205  GLN A  209  5                                   5
HELIX   10 AB1 PRO A  218  GLU A  223  1                                   6
HELIX   11 AB2 PRO A  226  GLU A  234  1                                   9
HELIX   12 AB3 PRO A  242  GLN A  249  1                                   8
HELIX   13 AB4 SER A  275  ALA A  289  1                                  15
HELIX   14 AB5 MET A  304  ASP A  309  1                                   6
HELIX   15 AB6 ASP A  309  ALA A  322  1                                  14
HELIX   16 AB7 ASN A  327  HIS A  331  5                                   5
HELIX   17 AB8 SER B   66  SER B   69  5                                   4
HELIX   18 AB9 TYR B   70  ALA B   78  1                                   9
HELIX   19 AC1 SER B  102  VAL B  117  1                                  16
HELIX   20 AC2 SER B  128  ALA B  141  1                                  14
HELIX   21 AC3 SER B  168  ALA B  172  5                                   5
HELIX   22 AC4 ALA B  173  LEU B  184  1                                  12
HELIX   23 AC5 GLY B  185  SER B  189  5                                   5
HELIX   24 AC6 ASP B  192  SER B  203  1                                  12
HELIX   25 AC7 ALA B  205  GLN B  209  5                                   5
HELIX   26 AC8 PRO B  218  GLU B  223  1                                   6
HELIX   27 AC9 PRO B  226  GLU B  234  1                                   9
HELIX   28 AD1 PRO B  242  GLN B  249  1                                   8
HELIX   29 AD2 SER B  275  ALA B  289  1                                  15
HELIX   30 AD3 MET B  304  ASP B  309  1                                   6
HELIX   31 AD4 ASP B  309  ALA B  322  1                                  14
SHEET    1 AA1 8 GLU A  34  ASP A  38  0
SHEET    2 AA1 8 VAL A  43  ALA A  49 -1  O  MET A  44   N  VAL A  37
SHEET    3 AA1 8 HIS A  82  VAL A  86 -1  O  ALA A  85   N  ALA A  47
SHEET    4 AA1 8 ALA A  56  LEU A  60  1  N  LEU A  59   O  PHE A  84
SHEET    5 AA1 8 VAL A 122  ASN A 127  1  O  ALA A 125   N  LEU A  58
SHEET    6 AA1 8 ILE A 146  GLU A 152  1  O  ARG A 147   N  VAL A 122
SHEET    7 AA1 8 ILE A 254  HIS A 258  1  O  LEU A 255   N  CYS A 151
SHEET    8 AA1 8 VAL A 293  SER A 297  1  O  ASP A 294   N  ILE A 256
SHEET    1 AA2 2 ARG A 261  ILE A 263  0
SHEET    2 AA2 2 LEU A 270  GLY A 272 -1  O  LEU A 271   N  THR A 262
SHEET    1 AA3 8 GLU B  34  ASP B  38  0
SHEET    2 AA3 8 VAL B  43  ALA B  49 -1  O  PHE B  46   N  ARG B  35
SHEET    3 AA3 8 HIS B  82  VAL B  86 -1  O  ALA B  85   N  ALA B  47
SHEET    4 AA3 8 ALA B  56  LEU B  60  1  N  LEU B  57   O  PHE B  84
SHEET    5 AA3 8 VAL B 122  ASN B 127  1  O  VAL B 123   N  LEU B  58
SHEET    6 AA3 8 ILE B 146  GLU B 152  1  O  ARG B 147   N  VAL B 122
SHEET    7 AA3 8 ILE B 254  HIS B 258  1  O  LEU B 255   N  CYS B 151
SHEET    8 AA3 8 VAL B 293  SER B 297  1  O  ASP B 294   N  ILE B 256
SHEET    1 AA4 2 ARG B 261  ILE B 263  0
SHEET    2 AA4 2 LEU B 270  GLY B 272 -1  O  LEU B 271   N  THR B 262
CRYST1   64.467  121.803  172.356  90.00  90.00  90.00 C 2 2 21     16
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.015512  0.000000  0.000000        0.00000
SCALE2      0.000000  0.008210  0.000000        0.00000
SCALE3      0.000000  0.000000  0.005802        0.00000
TER    4717      HIS A 332
TER    9413      ALA B 326
MASTER      338    0   10   31   20    0    0    6 5415    2  133   52
END