longtext: 8ekg-pdb

content
HEADER    HYDROLASE                               20-SEP-22   8EKG
TITLE     MHETASE VARIANT THR159VAL, MET192TYR, TYR252PHE, TYR503TRP
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: MONO(2-HYDROXYETHYL) TEREPHTHALATE HYDROLASE;
COMPND   3 CHAIN: A, B, C, D, E, F;
COMPND   4 SYNONYM: MHET HYDROLASE,MHETASE;
COMPND   5 EC: 3.1.1.102;
COMPND   6 ENGINEERED: YES;
COMPND   7 MUTATION: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: IDEONELLA SAKAIENSIS;
SOURCE   3 ORGANISM_TAXID: 1547922;
SOURCE   4 STRAIN: NBRC 110686 / TISTR 2288 / 201-F6;
SOURCE   5 GENE: ISF6_0224;
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562;
SOURCE   8 EXPRESSION_SYSTEM_STRAIN: SMG96;
SOURCE   9 EXPRESSION_SYSTEM_VARIANT: SHUFFLE;
SOURCE  10 EXPRESSION_SYSTEM_PLASMID: PET28A(+)
KEYWDS    PROTEIN ENGINEERING, MHETASE, PLASTIC DEGRADATION, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    J.W.SAUNDERS,R.L.FRKIC,C.J.JACKSON
REVDAT   1   18-OCT-23 8EKG    0
JRNL        AUTH   J.W.SAUNDERS,A.D.DAMRY,V.VONGSOUTHI,R.L.FRKIC,M.A.SPENCE,
JRNL        AUTH 2 P.M.YATES,M.D.MCLEOD,N.TOKURIKI,C.J.JACKSON
JRNL        TITL   MHETASE PROTEIN ENGINEERING USING A NOVEL COLORIMETRIC ASSAY
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   2
REMARK   2 RESOLUTION.    2.65 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX 1.20.1_4487
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : ML
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.65
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 43.87
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.960
REMARK   3   COMPLETENESS FOR RANGE        (%) : 96.0
REMARK   3   NUMBER OF REFLECTIONS             : 104701
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.187
REMARK   3   R VALUE            (WORKING SET) : 0.184
REMARK   3   FREE R VALUE                     : 0.241
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.670
REMARK   3   FREE R VALUE TEST SET COUNT      : 4885
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 43.8700 -  8.2200    0.95     3284   177  0.1405 0.1794
REMARK   3     2  8.2200 -  6.5300    0.96     3330   125  0.1438 0.1755
REMARK   3     3  6.5300 -  5.7100    0.95     3302   160  0.1534 0.1889
REMARK   3     4  5.7100 -  5.1800    0.96     3340   167  0.1418 0.1865
REMARK   3     5  5.1800 -  4.8100    0.95     3310   170  0.1360 0.2034
REMARK   3     6  4.8100 -  4.5300    0.96     3327   110  0.1260 0.1635
REMARK   3     7  4.5300 -  4.3000    0.95     3313   141  0.1248 0.1708
REMARK   3     8  4.3000 -  4.1200    0.96     3363   164  0.1368 0.1914
REMARK   3     9  4.1200 -  3.9600    0.96     3336   154  0.1470 0.1813
REMARK   3    10  3.9600 -  3.8200    0.95     3326   145  0.1517 0.2006
REMARK   3    11  3.8200 -  3.7000    0.96     3340   147  0.1616 0.2153
REMARK   3    12  3.7000 -  3.6000    0.97     3317   166  0.1656 0.2573
REMARK   3    13  3.6000 -  3.5000    0.95     3339   137  0.1777 0.2248
REMARK   3    14  3.5000 -  3.4200    0.96     3362   128  0.1820 0.2358
REMARK   3    15  3.4200 -  3.3400    0.96     3314   185  0.1915 0.2542
REMARK   3    16  3.3400 -  3.2700    0.97     3367   174  0.2248 0.2784
REMARK   3    17  3.2700 -  3.2000    0.97     3361   162  0.2379 0.2679
REMARK   3    18  3.2000 -  3.1400    0.95     3308   163  0.2464 0.3424
REMARK   3    19  3.1400 -  3.0900    0.97     3298   195  0.2493 0.3213
REMARK   3    20  3.0900 -  3.0300    0.96     3300   192  0.2492 0.3235
REMARK   3    21  3.0300 -  2.9800    0.95     3356   174  0.2574 0.3252
REMARK   3    22  2.9800 -  2.9400    0.96     3301   140  0.2711 0.3687
REMARK   3    23  2.9400 -  2.9000    0.96     3304   196  0.2793 0.3675
REMARK   3    24  2.9000 -  2.8500    0.95     3318   179  0.2736 0.3368
REMARK   3    25  2.8500 -  2.8200    0.96     3315   184  0.2724 0.3404
REMARK   3    26  2.8200 -  2.7800    0.98     3294   179  0.2839 0.3183
REMARK   3    27  2.7800 -  2.7400    0.95     3373   150  0.3098 0.3727
REMARK   3    28  2.7400 -  2.7100    0.96     3371   174  0.3174 0.3610
REMARK   3    29  2.7100 -  2.6800    0.97     3268   163  0.3335 0.3856
REMARK   3    30  2.6800 -  2.6500    0.96     3379   184  0.3375 0.3894
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL
REMARK   3   SOLVENT RADIUS     : 1.10
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.420
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 27.110
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 45.98
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 54.24
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :   NULL           NULL
REMARK   3   ANGLE     :   NULL           NULL
REMARK   3   CHIRALITY :   NULL           NULL
REMARK   3   PLANARITY :   NULL           NULL
REMARK   3   DIHEDRAL  :   NULL           NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : 17
REMARK   3   TLS GROUP : 1
REMARK   3    SELECTION: CHAIN 'D' AND (RESID 47 THROUGH 212 )
REMARK   3    ORIGIN FOR THE GROUP (A):  -0.6969  -4.9443  58.1698
REMARK   3    T TENSOR
REMARK   3      T11:   0.3783 T22:   0.3289
REMARK   3      T33:   0.4935 T12:   0.0502
REMARK   3      T13:  -0.0415 T23:  -0.0708
REMARK   3    L TENSOR
REMARK   3      L11:   2.7333 L22:   0.8356
REMARK   3      L33:   1.3890 L12:  -0.2734
REMARK   3      L13:   1.0366 L23:  -0.4120
REMARK   3    S TENSOR
REMARK   3      S11:   0.0417 S12:  -0.1616 S13:   0.1392
REMARK   3      S21:  -0.1477 S22:  -0.0785 S23:  -0.0214
REMARK   3      S31:  -0.0973 S32:   0.0004 S33:   0.0486
REMARK   3   TLS GROUP : 2
REMARK   3    SELECTION: CHAIN 'D' AND (RESID 213 THROUGH 533 )
REMARK   3    ORIGIN FOR THE GROUP (A):  -4.0427 -33.1504  55.5166
REMARK   3    T TENSOR
REMARK   3      T11:   0.4054 T22:   0.2122
REMARK   3      T33:   0.4630 T12:   0.0338
REMARK   3      T13:  -0.0793 T23:   0.0189
REMARK   3    L TENSOR
REMARK   3      L11:   1.2877 L22:   0.6906
REMARK   3      L33:   1.4390 L12:  -0.0978
REMARK   3      L13:   0.1531 L23:   0.5691
REMARK   3    S TENSOR
REMARK   3      S11:   0.0560 S12:  -0.1873 S13:  -0.2162
REMARK   3      S21:  -0.0073 S22:  -0.0142 S23:  -0.1257
REMARK   3      S31:   0.2217 S32:   0.0518 S33:  -0.0183
REMARK   3   TLS GROUP : 3
REMARK   3    SELECTION: CHAIN 'D' AND (RESID 534 THROUGH 603 )
REMARK   3    ORIGIN FOR THE GROUP (A): -25.6088 -25.8559  53.5778
REMARK   3    T TENSOR
REMARK   3      T11:   0.2614 T22:   0.3609
REMARK   3      T33:   0.4468 T12:   0.0352
REMARK   3      T13:  -0.0224 T23:  -0.0890
REMARK   3    L TENSOR
REMARK   3      L11:   1.8357 L22:   1.9675
REMARK   3      L33:   4.3118 L12:   1.5719
REMARK   3      L13:   1.9464 L23:   0.5233
REMARK   3    S TENSOR
REMARK   3      S11:   0.0746 S12:  -0.2606 S13:   0.0668
REMARK   3      S21:   0.0383 S22:  -0.3225 S23:   0.4202
REMARK   3      S31:   0.2020 S32:  -0.3271 S33:   0.2567
REMARK   3   TLS GROUP : 4
REMARK   3    SELECTION: CHAIN 'E' AND (RESID 46 THROUGH 212 )
REMARK   3    ORIGIN FOR THE GROUP (A): -17.2225  34.8974  69.7411
REMARK   3    T TENSOR
REMARK   3      T11:   0.3294 T22:   0.3885
REMARK   3      T33:   0.4934 T12:   0.0381
REMARK   3      T13:  -0.0818 T23:  -0.1154
REMARK   3    L TENSOR
REMARK   3      L11:   3.2385 L22:   1.0541
REMARK   3      L33:   2.4911 L12:  -0.5388
REMARK   3      L13:  -1.5160 L23:   0.7831
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0205 S12:   0.0141 S13:   0.1333
REMARK   3      S21:  -0.0397 S22:  -0.0095 S23:   0.0308
REMARK   3      S31:   0.0765 S32:  -0.1635 S33:   0.0407
REMARK   3   TLS GROUP : 5
REMARK   3    SELECTION: CHAIN 'E' AND (RESID 213 THROUGH 603 )
REMARK   3    ORIGIN FOR THE GROUP (A):  -6.9624  56.8169  84.5108
REMARK   3    T TENSOR
REMARK   3      T11:   0.4700 T22:   0.5616
REMARK   3      T33:   0.7221 T12:   0.0509
REMARK   3      T13:  -0.0718 T23:  -0.2706
REMARK   3    L TENSOR
REMARK   3      L11:   0.7136 L22:   1.9011
REMARK   3      L33:   0.5115 L12:  -0.1890
REMARK   3      L13:  -0.2869 L23:   0.3138
REMARK   3    S TENSOR
REMARK   3      S11:   0.0330 S12:  -0.2699 S13:   0.3098
REMARK   3      S21:   0.0341 S22:   0.0205 S23:   0.0045
REMARK   3      S31:  -0.1835 S32:   0.0173 S33:  -0.0532
REMARK   3   TLS GROUP : 6
REMARK   3    SELECTION: CHAIN 'F' AND (RESID 47 THROUGH 110 )
REMARK   3    ORIGIN FOR THE GROUP (A):  47.7991  12.0819 -35.2319
REMARK   3    T TENSOR
REMARK   3      T11:   0.4045 T22:   0.5131
REMARK   3      T33:   0.6963 T12:   0.0253
REMARK   3      T13:   0.0621 T23:  -0.0941
REMARK   3    L TENSOR
REMARK   3      L11:   4.2179 L22:   2.9102
REMARK   3      L33:   1.6181 L12:   1.6195
REMARK   3      L13:  -0.5221 L23:  -1.2725
REMARK   3    S TENSOR
REMARK   3      S11:  -0.3739 S12:   0.3308 S13:   0.0294
REMARK   3      S21:  -0.2619 S22:   0.1006 S23:  -0.3936
REMARK   3      S31:   0.3185 S32:  -0.0316 S33:   0.2780
REMARK   3   TLS GROUP : 7
REMARK   3    SELECTION: CHAIN 'F' AND (RESID 111 THROUGH 603 )
REMARK   3    ORIGIN FOR THE GROUP (A):  36.3588  28.0945 -12.4375
REMARK   3    T TENSOR
REMARK   3      T11:   0.4431 T22:   0.4378
REMARK   3      T33:   0.6395 T12:   0.0580
REMARK   3      T13:  -0.2022 T23:  -0.1186
REMARK   3    L TENSOR
REMARK   3      L11:   0.5518 L22:   1.1907
REMARK   3      L33:   1.0506 L12:  -0.4588
REMARK   3      L13:  -0.3977 L23:   0.1831
REMARK   3    S TENSOR
REMARK   3      S11:  -0.1856 S12:  -0.1324 S13:   0.3119
REMARK   3      S21:   0.3475 S22:   0.1522 S23:  -0.3880
REMARK   3      S31:  -0.1448 S32:   0.1361 S33:   0.0804
REMARK   3   TLS GROUP : 8
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 46 THROUGH 110 )
REMARK   3    ORIGIN FOR THE GROUP (A):   2.3585   9.6084 -38.5266
REMARK   3    T TENSOR
REMARK   3      T11:   0.4362 T22:   0.4065
REMARK   3      T33:   0.5257 T12:   0.0888
REMARK   3      T13:  -0.0607 T23:  -0.0547
REMARK   3    L TENSOR
REMARK   3      L11:   1.5743 L22:   2.0642
REMARK   3      L33:   1.4888 L12:   0.1513
REMARK   3      L13:  -0.0135 L23:   0.0657
REMARK   3    S TENSOR
REMARK   3      S11:  -0.1564 S12:   0.0505 S13:   0.2091
REMARK   3      S21:  -0.0413 S22:   0.1544 S23:  -0.0362
REMARK   3      S31:  -0.4123 S32:  -0.2199 S33:   0.0392
REMARK   3   TLS GROUP : 9
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 111 THROUGH 333 )
REMARK   3    ORIGIN FOR THE GROUP (A):  10.2389 -10.3263 -26.9980
REMARK   3    T TENSOR
REMARK   3      T11:   0.2646 T22:   0.3467
REMARK   3      T33:   0.4021 T12:   0.0521
REMARK   3      T13:  -0.0212 T23:  -0.0394
REMARK   3    L TENSOR
REMARK   3      L11:   0.2057 L22:   0.2840
REMARK   3      L33:   0.7536 L12:   0.1038
REMARK   3      L13:  -0.0581 L23:  -0.1169
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0014 S12:   0.0506 S13:   0.0113
REMARK   3      S21:   0.0034 S22:  -0.0184 S23:   0.0067
REMARK   3      S31:   0.0346 S32:   0.0062 S33:   0.0134
REMARK   3   TLS GROUP : 10
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 334 THROUGH 548 )
REMARK   3    ORIGIN FOR THE GROUP (A):  10.2185 -20.2342 -22.3703
REMARK   3    T TENSOR
REMARK   3      T11:   0.2935 T22:   0.3383
REMARK   3      T33:   0.4652 T12:   0.0554
REMARK   3      T13:  -0.0513 T23:  -0.0896
REMARK   3    L TENSOR
REMARK   3      L11:   0.7021 L22:   0.8605
REMARK   3      L33:   1.5819 L12:   0.2636
REMARK   3      L13:  -0.2914 L23:  -0.3799
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0534 S12:   0.1120 S13:  -0.0861
REMARK   3      S21:   0.0382 S22:  -0.0367 S23:  -0.0011
REMARK   3      S31:   0.1697 S32:  -0.0618 S33:   0.0916
REMARK   3   TLS GROUP : 11
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 549 THROUGH 603 )
REMARK   3    ORIGIN FOR THE GROUP (A):  33.0715 -11.6011 -21.4404
REMARK   3    T TENSOR
REMARK   3      T11:   0.3185 T22:   0.3764
REMARK   3      T33:   0.5051 T12:   0.0353
REMARK   3      T13:  -0.0132 T23:  -0.0358
REMARK   3    L TENSOR
REMARK   3      L11:   1.7138 L22:   0.3637
REMARK   3      L33:   4.5691 L12:  -0.2442
REMARK   3      L13:   0.9476 L23:   0.0368
REMARK   3    S TENSOR
REMARK   3      S11:   0.0520 S12:  -0.0262 S13:  -0.2002
REMARK   3      S21:  -0.0165 S22:  -0.1285 S23:   0.1001
REMARK   3      S31:   0.0279 S32:   0.5135 S33:   0.0708
REMARK   3   TLS GROUP : 12
REMARK   3    SELECTION: CHAIN 'B' AND (RESID 47 THROUGH 110 )
REMARK   3    ORIGIN FOR THE GROUP (A):  20.2693   0.2663  55.0420
REMARK   3    T TENSOR
REMARK   3      T11:   0.3725 T22:   0.3740
REMARK   3      T33:   0.4810 T12:   0.0787
REMARK   3      T13:  -0.0293 T23:  -0.0721
REMARK   3    L TENSOR
REMARK   3      L11:   3.8128 L22:   2.5830
REMARK   3      L33:   1.3981 L12:  -1.8534
REMARK   3      L13:   0.9924 L23:  -0.7853
REMARK   3    S TENSOR
REMARK   3      S11:  -0.1003 S12:  -0.2228 S13:  -0.3205
REMARK   3      S21:   0.2401 S22:   0.3675 S23:   0.0163
REMARK   3      S31:   0.0246 S32:  -0.0009 S33:  -0.2058
REMARK   3   TLS GROUP : 13
REMARK   3    SELECTION: CHAIN 'B' AND (RESID 111 THROUGH 326 )
REMARK   3    ORIGIN FOR THE GROUP (A):  26.8318   0.9414  32.8978
REMARK   3    T TENSOR
REMARK   3      T11:   0.3081 T22:   0.3742
REMARK   3      T33:   0.4728 T12:   0.0560
REMARK   3      T13:  -0.0572 T23:  -0.0595
REMARK   3    L TENSOR
REMARK   3      L11:   0.1097 L22:   0.3523
REMARK   3      L33:   0.8074 L12:  -0.0634
REMARK   3      L13:  -0.1516 L23:   0.0523
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0727 S12:  -0.0790 S13:  -0.0091
REMARK   3      S21:   0.0076 S22:   0.0283 S23:   0.0260
REMARK   3      S31:   0.0188 S32:   0.0026 S33:   0.0426
REMARK   3   TLS GROUP : 14
REMARK   3    SELECTION: CHAIN 'B' AND (RESID 327 THROUGH 382 )
REMARK   3    ORIGIN FOR THE GROUP (A):  30.6826  -5.6678   6.5541
REMARK   3    T TENSOR
REMARK   3      T11:   0.2346 T22:   0.3311
REMARK   3      T33:   0.2511 T12:   0.0369
REMARK   3      T13:  -0.0009 T23:   0.0149
REMARK   3    L TENSOR
REMARK   3      L11:   3.3690 L22:   1.2542
REMARK   3      L33:   4.3308 L12:   2.0518
REMARK   3      L13:   1.3204 L23:   0.9235
REMARK   3    S TENSOR
REMARK   3      S11:   0.0327 S12:   0.4708 S13:  -0.2029
REMARK   3      S21:  -0.1339 S22:   0.1069 S23:  -0.1862
REMARK   3      S31:   0.1812 S32:   0.1550 S33:  -0.1206
REMARK   3   TLS GROUP : 15
REMARK   3    SELECTION: CHAIN 'B' AND (RESID 383 THROUGH 603 )
REMARK   3    ORIGIN FOR THE GROUP (A):  31.7211   2.0375  25.6738
REMARK   3    T TENSOR
REMARK   3      T11:   0.3022 T22:   0.3418
REMARK   3      T33:   0.3425 T12:   0.0365
REMARK   3      T13:  -0.0112 T23:   0.0012
REMARK   3    L TENSOR
REMARK   3      L11:   2.0337 L22:   1.1751
REMARK   3      L33:   0.8637 L12:   0.2198
REMARK   3      L13:   0.5300 L23:   0.3998
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0151 S12:   0.0455 S13:   0.0621
REMARK   3      S21:  -0.0444 S22:  -0.0058 S23:  -0.0058
REMARK   3      S31:   0.0115 S32:   0.0578 S33:   0.0155
REMARK   3   TLS GROUP : 16
REMARK   3    SELECTION: CHAIN 'C' AND (RESID 47 THROUGH 212 )
REMARK   3    ORIGIN FOR THE GROUP (A):  24.5040  32.7749  57.4275
REMARK   3    T TENSOR
REMARK   3      T11:   0.3098 T22:   0.4677
REMARK   3      T33:   0.5380 T12:   0.0284
REMARK   3      T13:  -0.0843 T23:  -0.1658
REMARK   3    L TENSOR
REMARK   3      L11:   2.8151 L22:   1.3078
REMARK   3      L33:   2.5785 L12:   0.3904
REMARK   3      L13:  -1.8742 L23:  -0.2426
REMARK   3    S TENSOR
REMARK   3      S11:   0.0352 S12:  -0.2792 S13:   0.1556
REMARK   3      S21:   0.0508 S22:   0.1211 S23:  -0.0617
REMARK   3      S31:  -0.0512 S32:   0.4498 S33:  -0.1245
REMARK   3   TLS GROUP : 17
REMARK   3    SELECTION: CHAIN 'C' AND (RESID 213 THROUGH 603 )
REMARK   3    ORIGIN FOR THE GROUP (A):  13.7747  47.3971  35.5895
REMARK   3    T TENSOR
REMARK   3      T11:   0.4555 T22:   0.2911
REMARK   3      T33:   0.4995 T12:  -0.0060
REMARK   3      T13:  -0.0406 T23:  -0.1063
REMARK   3    L TENSOR
REMARK   3      L11:   0.6921 L22:   0.8410
REMARK   3      L33:   0.7133 L12:  -0.3644
REMARK   3      L13:  -0.3283 L23:   0.1940
REMARK   3    S TENSOR
REMARK   3      S11:   0.1140 S12:  -0.0581 S13:   0.1373
REMARK   3      S21:  -0.2269 S22:   0.0079 S23:   0.0459
REMARK   3      S31:  -0.2721 S32:   0.0736 S33:  -0.1265
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 8EKG COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 21-SEP-22.
REMARK 100 THE DEPOSITION ID IS D_1000268412.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 15-MAR-22
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 7.3
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : AUSTRALIAN SYNCHROTRON
REMARK 200  BEAMLINE                       : MX2
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9537
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : PIXEL
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS EIGER X 16M
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200  DATA SCALING SOFTWARE          : AIMLESS 0.7.7
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 104762
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.650
REMARK 200  RESOLUTION RANGE LOW       (A) : 43.870
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 96.0
REMARK 200  DATA REDUNDANCY                : 1.800
REMARK 200  R MERGE                    (I) : 0.11200
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 4.5000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.65
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.70
REMARK 200  COMPLETENESS FOR SHELL     (%) : 96.6
REMARK 200  DATA REDUNDANCY IN SHELL       : 1.90
REMARK 200  R MERGE FOR SHELL          (I) : 0.83600
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: 6QZ4
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 52.59
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.59
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 20% PEG 6000, 0.2 M MGCL2, 0.1 M HEPES
REMARK 280  PH 7.3, VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 291K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2, 3, 4, 5, 6
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 3
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 4
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: D
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 5
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: E
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 6
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: F
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A    12
REMARK 465     GLU A    13
REMARK 465     ASN A    14
REMARK 465     LEU A    15
REMARK 465     TYR A    16
REMARK 465     PHE A    17
REMARK 465     GLN A    18
REMARK 465     GLY A    19
REMARK 465     GLY A    20
REMARK 465     GLY A    21
REMARK 465     GLY A    22
REMARK 465     SER A    23
REMARK 465     THR A    24
REMARK 465     PRO A    25
REMARK 465     LEU A    26
REMARK 465     PRO A    27
REMARK 465     LEU A    28
REMARK 465     PRO A    29
REMARK 465     GLN A    30
REMARK 465     GLN A    31
REMARK 465     GLN A    32
REMARK 465     PRO A    33
REMARK 465     PRO A    34
REMARK 465     GLN A    35
REMARK 465     GLN A    36
REMARK 465     GLU A    37
REMARK 465     PRO A    38
REMARK 465     PRO A    39
REMARK 465     PRO A    40
REMARK 465     PRO A    41
REMARK 465     PRO A    42
REMARK 465     VAL A    43
REMARK 465     PRO A    44
REMARK 465     LEU A    45
REMARK 465     MET B    12
REMARK 465     GLU B    13
REMARK 465     ASN B    14
REMARK 465     LEU B    15
REMARK 465     TYR B    16
REMARK 465     PHE B    17
REMARK 465     GLN B    18
REMARK 465     GLY B    19
REMARK 465     GLY B    20
REMARK 465     GLY B    21
REMARK 465     GLY B    22
REMARK 465     SER B    23
REMARK 465     THR B    24
REMARK 465     PRO B    25
REMARK 465     LEU B    26
REMARK 465     PRO B    27
REMARK 465     LEU B    28
REMARK 465     PRO B    29
REMARK 465     GLN B    30
REMARK 465     GLN B    31
REMARK 465     GLN B    32
REMARK 465     PRO B    33
REMARK 465     PRO B    34
REMARK 465     GLN B    35
REMARK 465     GLN B    36
REMARK 465     GLU B    37
REMARK 465     PRO B    38
REMARK 465     PRO B    39
REMARK 465     PRO B    40
REMARK 465     PRO B    41
REMARK 465     PRO B    42
REMARK 465     VAL B    43
REMARK 465     PRO B    44
REMARK 465     LEU B    45
REMARK 465     ALA B    46
REMARK 465     MET C    12
REMARK 465     GLU C    13
REMARK 465     ASN C    14
REMARK 465     LEU C    15
REMARK 465     TYR C    16
REMARK 465     PHE C    17
REMARK 465     GLN C    18
REMARK 465     GLY C    19
REMARK 465     GLY C    20
REMARK 465     GLY C    21
REMARK 465     GLY C    22
REMARK 465     SER C    23
REMARK 465     THR C    24
REMARK 465     PRO C    25
REMARK 465     LEU C    26
REMARK 465     PRO C    27
REMARK 465     LEU C    28
REMARK 465     PRO C    29
REMARK 465     GLN C    30
REMARK 465     GLN C    31
REMARK 465     GLN C    32
REMARK 465     PRO C    33
REMARK 465     PRO C    34
REMARK 465     GLN C    35
REMARK 465     GLN C    36
REMARK 465     GLU C    37
REMARK 465     PRO C    38
REMARK 465     PRO C    39
REMARK 465     PRO C    40
REMARK 465     PRO C    41
REMARK 465     PRO C    42
REMARK 465     VAL C    43
REMARK 465     PRO C    44
REMARK 465     LEU C    45
REMARK 465     ALA C    46
REMARK 465     MET D    12
REMARK 465     GLU D    13
REMARK 465     ASN D    14
REMARK 465     LEU D    15
REMARK 465     TYR D    16
REMARK 465     PHE D    17
REMARK 465     GLN D    18
REMARK 465     GLY D    19
REMARK 465     GLY D    20
REMARK 465     GLY D    21
REMARK 465     GLY D    22
REMARK 465     SER D    23
REMARK 465     THR D    24
REMARK 465     PRO D    25
REMARK 465     LEU D    26
REMARK 465     PRO D    27
REMARK 465     LEU D    28
REMARK 465     PRO D    29
REMARK 465     GLN D    30
REMARK 465     GLN D    31
REMARK 465     GLN D    32
REMARK 465     PRO D    33
REMARK 465     PRO D    34
REMARK 465     GLN D    35
REMARK 465     GLN D    36
REMARK 465     GLU D    37
REMARK 465     PRO D    38
REMARK 465     PRO D    39
REMARK 465     PRO D    40
REMARK 465     PRO D    41
REMARK 465     PRO D    42
REMARK 465     VAL D    43
REMARK 465     PRO D    44
REMARK 465     LEU D    45
REMARK 465     ALA D    46
REMARK 465     MET E    12
REMARK 465     GLU E    13
REMARK 465     ASN E    14
REMARK 465     LEU E    15
REMARK 465     TYR E    16
REMARK 465     PHE E    17
REMARK 465     GLN E    18
REMARK 465     GLY E    19
REMARK 465     GLY E    20
REMARK 465     GLY E    21
REMARK 465     GLY E    22
REMARK 465     SER E    23
REMARK 465     THR E    24
REMARK 465     PRO E    25
REMARK 465     LEU E    26
REMARK 465     PRO E    27
REMARK 465     LEU E    28
REMARK 465     PRO E    29
REMARK 465     GLN E    30
REMARK 465     GLN E    31
REMARK 465     GLN E    32
REMARK 465     PRO E    33
REMARK 465     PRO E    34
REMARK 465     GLN E    35
REMARK 465     GLN E    36
REMARK 465     GLU E    37
REMARK 465     PRO E    38
REMARK 465     PRO E    39
REMARK 465     PRO E    40
REMARK 465     PRO E    41
REMARK 465     PRO E    42
REMARK 465     VAL E    43
REMARK 465     PRO E    44
REMARK 465     LEU E    45
REMARK 465     MET F    12
REMARK 465     GLU F    13
REMARK 465     ASN F    14
REMARK 465     LEU F    15
REMARK 465     TYR F    16
REMARK 465     PHE F    17
REMARK 465     GLN F    18
REMARK 465     GLY F    19
REMARK 465     GLY F    20
REMARK 465     GLY F    21
REMARK 465     GLY F    22
REMARK 465     SER F    23
REMARK 465     THR F    24
REMARK 465     PRO F    25
REMARK 465     LEU F    26
REMARK 465     PRO F    27
REMARK 465     LEU F    28
REMARK 465     PRO F    29
REMARK 465     GLN F    30
REMARK 465     GLN F    31
REMARK 465     GLN F    32
REMARK 465     PRO F    33
REMARK 465     PRO F    34
REMARK 465     GLN F    35
REMARK 465     GLN F    36
REMARK 465     GLU F    37
REMARK 465     PRO F    38
REMARK 465     PRO F    39
REMARK 465     PRO F    40
REMARK 465     PRO F    41
REMARK 465     PRO F    42
REMARK 465     VAL F    43
REMARK 465     PRO F    44
REMARK 465     LEU F    45
REMARK 465     ALA F    46
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    ASP A  56     -125.72     59.17
REMARK 500    ASP A  60       32.68    -96.13
REMARK 500    ASN A 134     -141.24     60.47
REMARK 500    ASN A 171       44.55    -86.79
REMARK 500    TYR A 194      -29.55   -149.09
REMARK 500    SEP A 225     -111.21     61.20
REMARK 500    ALA A 249       56.84     35.67
REMARK 500    ASP A 311       13.28   -143.80
REMARK 500    ASN A 316       75.45   -107.68
REMARK 500    ASN A 334        1.32   -159.52
REMARK 500    TYR A 373      -92.29   -134.52
REMARK 500    SER A 383     -153.51   -140.93
REMARK 500    SER A 413      -10.09   -144.23
REMARK 500    ALA A 469       43.74   -140.11
REMARK 500    SER A 491       36.79    -96.45
REMARK 500    CYS A 529      -27.23     68.25
REMARK 500    ARG A 550      -18.50     68.06
REMARK 500    ALA B  67       35.19    -86.39
REMARK 500    ALA B  73       83.49   -154.55
REMARK 500    GLU B  90      132.58    -39.71
REMARK 500    ASN B 134     -140.58     59.70
REMARK 500    TYR B 194      -33.21   -158.08
REMARK 500    SEP B 225     -112.43     66.32
REMARK 500    ALA B 249       59.14     38.06
REMARK 500    ASP B 276     -167.98   -100.40
REMARK 500    TYR B 373     -102.38   -144.36
REMARK 500    SER B 383     -144.28   -133.04
REMARK 500    ILE B 447      -49.93   -135.25
REMARK 500    SER B 491       41.85    -95.29
REMARK 500    ASN B 527     -137.75    -84.83
REMARK 500    CYS B 529      -36.84     68.82
REMARK 500    ASN C  58       55.99   -100.22
REMARK 500    ASP C  60      -15.97     69.84
REMARK 500    MET C  61       80.89    -66.77
REMARK 500    ALA C  67       45.85    -97.82
REMARK 500    ASN C 134     -147.99     59.07
REMARK 500    ASP C 172       78.04   -115.28
REMARK 500    ALA C 176       33.47    -96.38
REMARK 500    TYR C 194      -23.95   -159.85
REMARK 500    SEP C 225     -108.87     55.43
REMARK 500    ASP C 276     -156.97    -96.48
REMARK 500    ASN C 316       74.06   -100.21
REMARK 500    TYR C 373      -93.90   -137.35
REMARK 500    SER C 383     -143.55   -138.47
REMARK 500    SER C 456      118.73   -162.32
REMARK 500    ALA C 469       51.19   -147.67
REMARK 500    PHE C 517       -8.23   -150.34
REMARK 500    ASN C 527     -144.85    -84.00
REMARK 500    CYS C 529      -25.23     68.18
REMARK 500    ASN D  58       42.77   -103.93
REMARK 500
REMARK 500 THIS ENTRY HAS      94 RAMACHANDRAN OUTLIERS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 525
REMARK 525 SOLVENT
REMARK 525
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 525 NUMBER; I=INSERTION CODE):
REMARK 525
REMARK 525  M RES CSSEQI
REMARK 525    HOH A 868        DISTANCE =  7.11 ANGSTROMS
REMARK 525    HOH A 869        DISTANCE =  8.30 ANGSTROMS
REMARK 525    HOH A 870        DISTANCE = 11.32 ANGSTROMS
REMARK 525    HOH B 890        DISTANCE =  6.14 ANGSTROMS
REMARK 525    HOH B 891        DISTANCE =  6.27 ANGSTROMS
REMARK 525    HOH C 865        DISTANCE =  5.83 ANGSTROMS
REMARK 525    HOH C 866        DISTANCE =  6.00 ANGSTROMS
REMARK 525    HOH C 867        DISTANCE =  6.00 ANGSTROMS
REMARK 525    HOH C 868        DISTANCE =  6.07 ANGSTROMS
REMARK 525    HOH C 869        DISTANCE =  8.44 ANGSTROMS
REMARK 525    HOH C 870        DISTANCE =  8.51 ANGSTROMS
REMARK 525    HOH C 871        DISTANCE =  8.87 ANGSTROMS
REMARK 525    HOH E 849        DISTANCE =  6.17 ANGSTROMS
REMARK 525    HOH E 850        DISTANCE =  6.76 ANGSTROMS
REMARK 525    HOH E 851        DISTANCE =  7.78 ANGSTROMS
REMARK 525    HOH E 852        DISTANCE =  8.58 ANGSTROMS
REMARK 525    HOH F 851        DISTANCE =  5.95 ANGSTROMS
REMARK 525    HOH F 852        DISTANCE =  6.66 ANGSTROMS
REMARK 525    HOH F 853        DISTANCE =  6.80 ANGSTROMS
REMARK 525    HOH F 854        DISTANCE =  7.25 ANGSTROMS
REMARK 525    HOH F 855        DISTANCE =  9.18 ANGSTROMS
REMARK 620
REMARK 620 METAL COORDINATION
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA A 701  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 ASP A 304   O
REMARK 620 2 ASP A 304   OD1  58.1
REMARK 620 3 ASP A 307   OD1  60.8 115.0
REMARK 620 4 ASP A 307   OD2 105.8 162.7  47.7
REMARK 620 5 LEU A 309   O    61.8  68.6  65.0  99.1
REMARK 620 6 ASP A 311   OD1 115.2  71.5 119.8 114.8  63.6
REMARK 620 7 ILE A 313   O    99.4  75.1 135.6 116.5 143.7 104.5
REMARK 620 N                    1     2     3     4     5     6
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA B 701  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 ASP B 304   O
REMARK 620 2 ASP B 304   OD1  70.2
REMARK 620 3 ASP B 307   OD1  86.3 153.3
REMARK 620 4 ASP B 307   OD2  62.7 124.4  47.9
REMARK 620 5 LEU B 309   O    70.0  83.4  76.4 105.5
REMARK 620 6 ASP B 311   OD1 140.0  76.4 118.4 157.0  85.1
REMARK 620 7 ILE B 313   O   103.2  75.4 124.0  87.7 158.8  88.8
REMARK 620 N                    1     2     3     4     5     6
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA C 701  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 ASP C 304   O
REMARK 620 2 ASP C 304   OD1  69.0
REMARK 620 3 ASP C 307   OD1  79.5 146.8
REMARK 620 4 ASP C 307   OD2  69.4 110.1  46.1
REMARK 620 5 LEU C 309   O    73.7  95.8  84.9 122.1
REMARK 620 6 ASP C 311   OD1 136.5  72.6 140.6 145.5  90.8
REMARK 620 7 ILE C 313   O    98.8  60.8 116.4  73.4 156.3  79.3
REMARK 620 N                    1     2     3     4     5     6
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA D 701  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 ASP D 304   O
REMARK 620 2 ASP D 304   OD1  61.1
REMARK 620 3 ASP D 307   OD1  73.7 133.0
REMARK 620 4 ASP D 307   OD2  60.8 109.1  52.6
REMARK 620 5 LEU D 309   O    66.6  72.3  78.9 115.2
REMARK 620 6 ASP D 311   OD1 126.4  66.9 147.6 156.2  86.6
REMARK 620 7 ILE D 313   O    97.0  73.2 127.2  77.1 145.5  79.4
REMARK 620 N                    1     2     3     4     5     6
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA E 701  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 ASP E 304   O
REMARK 620 2 ASP E 304   OD1  66.7
REMARK 620 3 ASP E 307   OD1  69.5 135.4
REMARK 620 4 ASP E 307   OD2  60.8 111.4  49.7
REMARK 620 5 LEU E 309   O    73.7  87.9  72.2 114.5
REMARK 620 6 ASP E 311   OD1 135.8  70.2 148.9 149.8  95.6
REMARK 620 7 ILE E 313   O   101.1  72.2 125.1  77.8 159.7  74.1
REMARK 620 N                    1     2     3     4     5     6
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              CA F 701  CA
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 ASP F 304   O
REMARK 620 2 ASP F 304   OD1  69.9
REMARK 620 3 ASP F 307   OD1  80.1 145.9
REMARK 620 4 ASP F 307   OD2  65.3 123.2  51.7
REMARK 620 5 LEU F 309   O    78.2  83.5  74.7 117.9
REMARK 620 6 ASP F 311   OD1 142.3  75.6 126.0 151.2  83.4
REMARK 620 7 ILE F 313   O   103.5  77.9 126.1  80.5 159.3  83.2
REMARK 620 N                    1     2     3     4     5     6
DBREF1 8EKG A   20   603  UNP                  MHETH_IDESA
DBREF2 8EKG A     A0A0K8P8E7                         20         603
DBREF1 8EKG B   20   603  UNP                  MHETH_IDESA
DBREF2 8EKG B     A0A0K8P8E7                         20         603
DBREF1 8EKG C   20   603  UNP                  MHETH_IDESA
DBREF2 8EKG C     A0A0K8P8E7                         20         603
DBREF1 8EKG D   20   603  UNP                  MHETH_IDESA
DBREF2 8EKG D     A0A0K8P8E7                         20         603
DBREF1 8EKG E   20   603  UNP                  MHETH_IDESA
DBREF2 8EKG E     A0A0K8P8E7                         20         603
DBREF1 8EKG F   20   603  UNP                  MHETH_IDESA
DBREF2 8EKG F     A0A0K8P8E7                         20         603
SEQADV 8EKG MET A   12  UNP  A0A0K8P8E           INITIATING METHIONINE
SEQADV 8EKG GLU A   13  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG ASN A   14  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG LEU A   15  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG TYR A   16  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG PHE A   17  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG GLN A   18  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG GLY A   19  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG VAL A  159  UNP  A0A0K8P8E THR   159 ENGINEERED MUTATION
SEQADV 8EKG TYR A  192  UNP  A0A0K8P8E MET   192 ENGINEERED MUTATION
SEQADV 8EKG PHE A  252  UNP  A0A0K8P8E TYR   252 ENGINEERED MUTATION
SEQADV 8EKG TRP A  503  UNP  A0A0K8P8E TYR   503 ENGINEERED MUTATION
SEQADV 8EKG MET B   12  UNP  A0A0K8P8E           INITIATING METHIONINE
SEQADV 8EKG GLU B   13  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG ASN B   14  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG LEU B   15  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG TYR B   16  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG PHE B   17  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG GLN B   18  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG GLY B   19  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG VAL B  159  UNP  A0A0K8P8E THR   159 ENGINEERED MUTATION
SEQADV 8EKG TYR B  192  UNP  A0A0K8P8E MET   192 ENGINEERED MUTATION
SEQADV 8EKG PHE B  252  UNP  A0A0K8P8E TYR   252 ENGINEERED MUTATION
SEQADV 8EKG TRP B  503  UNP  A0A0K8P8E TYR   503 ENGINEERED MUTATION
SEQADV 8EKG MET C   12  UNP  A0A0K8P8E           INITIATING METHIONINE
SEQADV 8EKG GLU C   13  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG ASN C   14  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG LEU C   15  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG TYR C   16  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG PHE C   17  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG GLN C   18  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG GLY C   19  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG VAL C  159  UNP  A0A0K8P8E THR   159 ENGINEERED MUTATION
SEQADV 8EKG TYR C  192  UNP  A0A0K8P8E MET   192 ENGINEERED MUTATION
SEQADV 8EKG PHE C  252  UNP  A0A0K8P8E TYR   252 ENGINEERED MUTATION
SEQADV 8EKG TRP C  503  UNP  A0A0K8P8E TYR   503 ENGINEERED MUTATION
SEQADV 8EKG MET D   12  UNP  A0A0K8P8E           INITIATING METHIONINE
SEQADV 8EKG GLU D   13  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG ASN D   14  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG LEU D   15  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG TYR D   16  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG PHE D   17  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG GLN D   18  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG GLY D   19  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG VAL D  159  UNP  A0A0K8P8E THR   159 ENGINEERED MUTATION
SEQADV 8EKG TYR D  192  UNP  A0A0K8P8E MET   192 ENGINEERED MUTATION
SEQADV 8EKG PHE D  252  UNP  A0A0K8P8E TYR   252 ENGINEERED MUTATION
SEQADV 8EKG TRP D  503  UNP  A0A0K8P8E TYR   503 ENGINEERED MUTATION
SEQADV 8EKG MET E   12  UNP  A0A0K8P8E           INITIATING METHIONINE
SEQADV 8EKG GLU E   13  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG ASN E   14  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG LEU E   15  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG TYR E   16  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG PHE E   17  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG GLN E   18  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG GLY E   19  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG VAL E  159  UNP  A0A0K8P8E THR   159 ENGINEERED MUTATION
SEQADV 8EKG TYR E  192  UNP  A0A0K8P8E MET   192 ENGINEERED MUTATION
SEQADV 8EKG PHE E  252  UNP  A0A0K8P8E TYR   252 ENGINEERED MUTATION
SEQADV 8EKG TRP E  503  UNP  A0A0K8P8E TYR   503 ENGINEERED MUTATION
SEQADV 8EKG MET F   12  UNP  A0A0K8P8E           INITIATING METHIONINE
SEQADV 8EKG GLU F   13  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG ASN F   14  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG LEU F   15  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG TYR F   16  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG PHE F   17  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG GLN F   18  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG GLY F   19  UNP  A0A0K8P8E           EXPRESSION TAG
SEQADV 8EKG VAL F  159  UNP  A0A0K8P8E THR   159 ENGINEERED MUTATION
SEQADV 8EKG TYR F  192  UNP  A0A0K8P8E MET   192 ENGINEERED MUTATION
SEQADV 8EKG PHE F  252  UNP  A0A0K8P8E TYR   252 ENGINEERED MUTATION
SEQADV 8EKG TRP F  503  UNP  A0A0K8P8E TYR   503 ENGINEERED MUTATION
SEQRES   1 A  592  MET GLU ASN LEU TYR PHE GLN GLY GLY GLY GLY SER THR
SEQRES   2 A  592  PRO LEU PRO LEU PRO GLN GLN GLN PRO PRO GLN GLN GLU
SEQRES   3 A  592  PRO PRO PRO PRO PRO VAL PRO LEU ALA SER ARG ALA ALA
SEQRES   4 A  592  CYS GLU ALA LEU LYS ASP GLY ASN GLY ASP MET VAL TRP
SEQRES   5 A  592  PRO ASN ALA ALA THR VAL VAL GLU VAL ALA ALA TRP ARG
SEQRES   6 A  592  ASP ALA ALA PRO ALA THR ALA SER ALA ALA ALA LEU PRO
SEQRES   7 A  592  GLU HIS CYS GLU VAL SER GLY ALA ILE ALA LYS ARG THR
SEQRES   8 A  592  GLY ILE ASP GLY TYR PRO TYR GLU ILE LYS PHE ARG LEU
SEQRES   9 A  592  ARG MET PRO ALA GLU TRP ASN GLY ARG PHE PHE MET GLU
SEQRES  10 A  592  GLY GLY SER GLY THR ASN GLY SER LEU SER ALA ALA THR
SEQRES  11 A  592  GLY SER ILE GLY GLY GLY GLN ILE ALA SER ALA LEU SER
SEQRES  12 A  592  ARG ASN PHE ALA VAL ILE ALA THR ASP GLY GLY HIS ASP
SEQRES  13 A  592  ASN ALA VAL ASN ASP ASN PRO ASP ALA LEU GLY THR VAL
SEQRES  14 A  592  ALA PHE GLY LEU ASP PRO GLN ALA ARG LEU ASP TYR GLY
SEQRES  15 A  592  TYR ASN SER TYR ASP GLN VAL THR GLN ALA GLY LYS ALA
SEQRES  16 A  592  ALA VAL ALA ARG PHE TYR GLY ARG ALA ALA ASP LYS SER
SEQRES  17 A  592  TYR PHE ILE GLY CYS SEP GLU GLY GLY ARG GLU GLY MET
SEQRES  18 A  592  MET LEU SER GLN ARG PHE PRO SER HIS TYR ASP GLY ILE
SEQRES  19 A  592  VAL ALA GLY ALA PRO GLY PHE GLN LEU PRO LYS ALA GLY
SEQRES  20 A  592  ILE SER GLY ALA TRP THR THR GLN SER LEU ALA PRO ALA
SEQRES  21 A  592  ALA VAL GLY LEU ASP ALA GLN GLY VAL PRO LEU ILE ASN
SEQRES  22 A  592  LYS SER PHE SER ASP ALA ASP LEU HIS LEU LEU SER GLN
SEQRES  23 A  592  ALA ILE LEU GLY THR CYS ASP ALA LEU ASP GLY LEU ALA
SEQRES  24 A  592  ASP GLY ILE VAL ASP ASN TYR ARG ALA CYS GLN ALA ALA
SEQRES  25 A  592  PHE ASP PRO ALA THR ALA ALA ASN PRO ALA ASN GLY GLN
SEQRES  26 A  592  ALA LEU GLN CYS VAL GLY ALA LYS THR ALA ASP CYS LEU
SEQRES  27 A  592  SER PRO VAL GLN VAL THR ALA ILE LYS ARG ALA MET ALA
SEQRES  28 A  592  GLY PRO VAL ASN SER ALA GLY THR PRO LEU TYR ASN ARG
SEQRES  29 A  592  TRP ALA TRP ASP ALA GLY MET SER GLY LEU SER GLY THR
SEQRES  30 A  592  THR TYR ASN GLN GLY TRP ARG SER TRP TRP LEU GLY SER
SEQRES  31 A  592  PHE ASN SER SER ALA ASN ASN ALA GLN ARG VAL SER GLY
SEQRES  32 A  592  PHE SER ALA ARG SER TRP LEU VAL ASP PHE ALA THR PRO
SEQRES  33 A  592  PRO GLU PRO MET PRO MET THR GLN VAL ALA ALA ARG MET
SEQRES  34 A  592  MET LYS PHE ASP PHE ASP ILE ASP PRO LEU LYS ILE TRP
SEQRES  35 A  592  ALA THR SER GLY GLN PHE THR GLN SER SER MET ASP TRP
SEQRES  36 A  592  HIS GLY ALA THR SER THR ASP LEU ALA ALA PHE ARG ASP
SEQRES  37 A  592  ARG GLY GLY LYS MET ILE LEU TYR HIS GLY MET SER ASP
SEQRES  38 A  592  ALA ALA PHE SER ALA LEU ASP THR ALA ASP TRP TYR GLU
SEQRES  39 A  592  ARG LEU GLY ALA ALA MET PRO GLY ALA ALA GLY PHE ALA
SEQRES  40 A  592  ARG LEU PHE LEU VAL PRO GLY MET ASN HIS CYS SER GLY
SEQRES  41 A  592  GLY PRO GLY THR ASP ARG PHE ASP MET LEU THR PRO LEU
SEQRES  42 A  592  VAL ALA TRP VAL GLU ARG GLY GLU ALA PRO ASP GLN ILE
SEQRES  43 A  592  SER ALA TRP SER GLY THR PRO GLY TYR PHE GLY VAL ALA
SEQRES  44 A  592  ALA ARG THR ARG PRO LEU CYS PRO TYR PRO GLN ILE ALA
SEQRES  45 A  592  ARG TYR LYS GLY SER GLY ASP ILE ASN THR GLU ALA ASN
SEQRES  46 A  592  PHE ALA CYS ALA ALA PRO PRO
SEQRES   1 B  592  MET GLU ASN LEU TYR PHE GLN GLY GLY GLY GLY SER THR
SEQRES   2 B  592  PRO LEU PRO LEU PRO GLN GLN GLN PRO PRO GLN GLN GLU
SEQRES   3 B  592  PRO PRO PRO PRO PRO VAL PRO LEU ALA SER ARG ALA ALA
SEQRES   4 B  592  CYS GLU ALA LEU LYS ASP GLY ASN GLY ASP MET VAL TRP
SEQRES   5 B  592  PRO ASN ALA ALA THR VAL VAL GLU VAL ALA ALA TRP ARG
SEQRES   6 B  592  ASP ALA ALA PRO ALA THR ALA SER ALA ALA ALA LEU PRO
SEQRES   7 B  592  GLU HIS CYS GLU VAL SER GLY ALA ILE ALA LYS ARG THR
SEQRES   8 B  592  GLY ILE ASP GLY TYR PRO TYR GLU ILE LYS PHE ARG LEU
SEQRES   9 B  592  ARG MET PRO ALA GLU TRP ASN GLY ARG PHE PHE MET GLU
SEQRES  10 B  592  GLY GLY SER GLY THR ASN GLY SER LEU SER ALA ALA THR
SEQRES  11 B  592  GLY SER ILE GLY GLY GLY GLN ILE ALA SER ALA LEU SER
SEQRES  12 B  592  ARG ASN PHE ALA VAL ILE ALA THR ASP GLY GLY HIS ASP
SEQRES  13 B  592  ASN ALA VAL ASN ASP ASN PRO ASP ALA LEU GLY THR VAL
SEQRES  14 B  592  ALA PHE GLY LEU ASP PRO GLN ALA ARG LEU ASP TYR GLY
SEQRES  15 B  592  TYR ASN SER TYR ASP GLN VAL THR GLN ALA GLY LYS ALA
SEQRES  16 B  592  ALA VAL ALA ARG PHE TYR GLY ARG ALA ALA ASP LYS SER
SEQRES  17 B  592  TYR PHE ILE GLY CYS SEP GLU GLY GLY ARG GLU GLY MET
SEQRES  18 B  592  MET LEU SER GLN ARG PHE PRO SER HIS TYR ASP GLY ILE
SEQRES  19 B  592  VAL ALA GLY ALA PRO GLY PHE GLN LEU PRO LYS ALA GLY
SEQRES  20 B  592  ILE SER GLY ALA TRP THR THR GLN SER LEU ALA PRO ALA
SEQRES  21 B  592  ALA VAL GLY LEU ASP ALA GLN GLY VAL PRO LEU ILE ASN
SEQRES  22 B  592  LYS SER PHE SER ASP ALA ASP LEU HIS LEU LEU SER GLN
SEQRES  23 B  592  ALA ILE LEU GLY THR CYS ASP ALA LEU ASP GLY LEU ALA
SEQRES  24 B  592  ASP GLY ILE VAL ASP ASN TYR ARG ALA CYS GLN ALA ALA
SEQRES  25 B  592  PHE ASP PRO ALA THR ALA ALA ASN PRO ALA ASN GLY GLN
SEQRES  26 B  592  ALA LEU GLN CYS VAL GLY ALA LYS THR ALA ASP CYS LEU
SEQRES  27 B  592  SER PRO VAL GLN VAL THR ALA ILE LYS ARG ALA MET ALA
SEQRES  28 B  592  GLY PRO VAL ASN SER ALA GLY THR PRO LEU TYR ASN ARG
SEQRES  29 B  592  TRP ALA TRP ASP ALA GLY MET SER GLY LEU SER GLY THR
SEQRES  30 B  592  THR TYR ASN GLN GLY TRP ARG SER TRP TRP LEU GLY SER
SEQRES  31 B  592  PHE ASN SER SER ALA ASN ASN ALA GLN ARG VAL SER GLY
SEQRES  32 B  592  PHE SER ALA ARG SER TRP LEU VAL ASP PHE ALA THR PRO
SEQRES  33 B  592  PRO GLU PRO MET PRO MET THR GLN VAL ALA ALA ARG MET
SEQRES  34 B  592  MET LYS PHE ASP PHE ASP ILE ASP PRO LEU LYS ILE TRP
SEQRES  35 B  592  ALA THR SER GLY GLN PHE THR GLN SER SER MET ASP TRP
SEQRES  36 B  592  HIS GLY ALA THR SER THR ASP LEU ALA ALA PHE ARG ASP
SEQRES  37 B  592  ARG GLY GLY LYS MET ILE LEU TYR HIS GLY MET SER ASP
SEQRES  38 B  592  ALA ALA PHE SER ALA LEU ASP THR ALA ASP TRP TYR GLU
SEQRES  39 B  592  ARG LEU GLY ALA ALA MET PRO GLY ALA ALA GLY PHE ALA
SEQRES  40 B  592  ARG LEU PHE LEU VAL PRO GLY MET ASN HIS CYS SER GLY
SEQRES  41 B  592  GLY PRO GLY THR ASP ARG PHE ASP MET LEU THR PRO LEU
SEQRES  42 B  592  VAL ALA TRP VAL GLU ARG GLY GLU ALA PRO ASP GLN ILE
SEQRES  43 B  592  SER ALA TRP SER GLY THR PRO GLY TYR PHE GLY VAL ALA
SEQRES  44 B  592  ALA ARG THR ARG PRO LEU CYS PRO TYR PRO GLN ILE ALA
SEQRES  45 B  592  ARG TYR LYS GLY SER GLY ASP ILE ASN THR GLU ALA ASN
SEQRES  46 B  592  PHE ALA CYS ALA ALA PRO PRO
SEQRES   1 C  592  MET GLU ASN LEU TYR PHE GLN GLY GLY GLY GLY SER THR
SEQRES   2 C  592  PRO LEU PRO LEU PRO GLN GLN GLN PRO PRO GLN GLN GLU
SEQRES   3 C  592  PRO PRO PRO PRO PRO VAL PRO LEU ALA SER ARG ALA ALA
SEQRES   4 C  592  CYS GLU ALA LEU LYS ASP GLY ASN GLY ASP MET VAL TRP
SEQRES   5 C  592  PRO ASN ALA ALA THR VAL VAL GLU VAL ALA ALA TRP ARG
SEQRES   6 C  592  ASP ALA ALA PRO ALA THR ALA SER ALA ALA ALA LEU PRO
SEQRES   7 C  592  GLU HIS CYS GLU VAL SER GLY ALA ILE ALA LYS ARG THR
SEQRES   8 C  592  GLY ILE ASP GLY TYR PRO TYR GLU ILE LYS PHE ARG LEU
SEQRES   9 C  592  ARG MET PRO ALA GLU TRP ASN GLY ARG PHE PHE MET GLU
SEQRES  10 C  592  GLY GLY SER GLY THR ASN GLY SER LEU SER ALA ALA THR
SEQRES  11 C  592  GLY SER ILE GLY GLY GLY GLN ILE ALA SER ALA LEU SER
SEQRES  12 C  592  ARG ASN PHE ALA VAL ILE ALA THR ASP GLY GLY HIS ASP
SEQRES  13 C  592  ASN ALA VAL ASN ASP ASN PRO ASP ALA LEU GLY THR VAL
SEQRES  14 C  592  ALA PHE GLY LEU ASP PRO GLN ALA ARG LEU ASP TYR GLY
SEQRES  15 C  592  TYR ASN SER TYR ASP GLN VAL THR GLN ALA GLY LYS ALA
SEQRES  16 C  592  ALA VAL ALA ARG PHE TYR GLY ARG ALA ALA ASP LYS SER
SEQRES  17 C  592  TYR PHE ILE GLY CYS SEP GLU GLY GLY ARG GLU GLY MET
SEQRES  18 C  592  MET LEU SER GLN ARG PHE PRO SER HIS TYR ASP GLY ILE
SEQRES  19 C  592  VAL ALA GLY ALA PRO GLY PHE GLN LEU PRO LYS ALA GLY
SEQRES  20 C  592  ILE SER GLY ALA TRP THR THR GLN SER LEU ALA PRO ALA
SEQRES  21 C  592  ALA VAL GLY LEU ASP ALA GLN GLY VAL PRO LEU ILE ASN
SEQRES  22 C  592  LYS SER PHE SER ASP ALA ASP LEU HIS LEU LEU SER GLN
SEQRES  23 C  592  ALA ILE LEU GLY THR CYS ASP ALA LEU ASP GLY LEU ALA
SEQRES  24 C  592  ASP GLY ILE VAL ASP ASN TYR ARG ALA CYS GLN ALA ALA
SEQRES  25 C  592  PHE ASP PRO ALA THR ALA ALA ASN PRO ALA ASN GLY GLN
SEQRES  26 C  592  ALA LEU GLN CYS VAL GLY ALA LYS THR ALA ASP CYS LEU
SEQRES  27 C  592  SER PRO VAL GLN VAL THR ALA ILE LYS ARG ALA MET ALA
SEQRES  28 C  592  GLY PRO VAL ASN SER ALA GLY THR PRO LEU TYR ASN ARG
SEQRES  29 C  592  TRP ALA TRP ASP ALA GLY MET SER GLY LEU SER GLY THR
SEQRES  30 C  592  THR TYR ASN GLN GLY TRP ARG SER TRP TRP LEU GLY SER
SEQRES  31 C  592  PHE ASN SER SER ALA ASN ASN ALA GLN ARG VAL SER GLY
SEQRES  32 C  592  PHE SER ALA ARG SER TRP LEU VAL ASP PHE ALA THR PRO
SEQRES  33 C  592  PRO GLU PRO MET PRO MET THR GLN VAL ALA ALA ARG MET
SEQRES  34 C  592  MET LYS PHE ASP PHE ASP ILE ASP PRO LEU LYS ILE TRP
SEQRES  35 C  592  ALA THR SER GLY GLN PHE THR GLN SER SER MET ASP TRP
SEQRES  36 C  592  HIS GLY ALA THR SER THR ASP LEU ALA ALA PHE ARG ASP
SEQRES  37 C  592  ARG GLY GLY LYS MET ILE LEU TYR HIS GLY MET SER ASP
SEQRES  38 C  592  ALA ALA PHE SER ALA LEU ASP THR ALA ASP TRP TYR GLU
SEQRES  39 C  592  ARG LEU GLY ALA ALA MET PRO GLY ALA ALA GLY PHE ALA
SEQRES  40 C  592  ARG LEU PHE LEU VAL PRO GLY MET ASN HIS CYS SER GLY
SEQRES  41 C  592  GLY PRO GLY THR ASP ARG PHE ASP MET LEU THR PRO LEU
SEQRES  42 C  592  VAL ALA TRP VAL GLU ARG GLY GLU ALA PRO ASP GLN ILE
SEQRES  43 C  592  SER ALA TRP SER GLY THR PRO GLY TYR PHE GLY VAL ALA
SEQRES  44 C  592  ALA ARG THR ARG PRO LEU CYS PRO TYR PRO GLN ILE ALA
SEQRES  45 C  592  ARG TYR LYS GLY SER GLY ASP ILE ASN THR GLU ALA ASN
SEQRES  46 C  592  PHE ALA CYS ALA ALA PRO PRO
SEQRES   1 D  592  MET GLU ASN LEU TYR PHE GLN GLY GLY GLY GLY SER THR
SEQRES   2 D  592  PRO LEU PRO LEU PRO GLN GLN GLN PRO PRO GLN GLN GLU
SEQRES   3 D  592  PRO PRO PRO PRO PRO VAL PRO LEU ALA SER ARG ALA ALA
SEQRES   4 D  592  CYS GLU ALA LEU LYS ASP GLY ASN GLY ASP MET VAL TRP
SEQRES   5 D  592  PRO ASN ALA ALA THR VAL VAL GLU VAL ALA ALA TRP ARG
SEQRES   6 D  592  ASP ALA ALA PRO ALA THR ALA SER ALA ALA ALA LEU PRO
SEQRES   7 D  592  GLU HIS CYS GLU VAL SER GLY ALA ILE ALA LYS ARG THR
SEQRES   8 D  592  GLY ILE ASP GLY TYR PRO TYR GLU ILE LYS PHE ARG LEU
SEQRES   9 D  592  ARG MET PRO ALA GLU TRP ASN GLY ARG PHE PHE MET GLU
SEQRES  10 D  592  GLY GLY SER GLY THR ASN GLY SER LEU SER ALA ALA THR
SEQRES  11 D  592  GLY SER ILE GLY GLY GLY GLN ILE ALA SER ALA LEU SER
SEQRES  12 D  592  ARG ASN PHE ALA VAL ILE ALA THR ASP GLY GLY HIS ASP
SEQRES  13 D  592  ASN ALA VAL ASN ASP ASN PRO ASP ALA LEU GLY THR VAL
SEQRES  14 D  592  ALA PHE GLY LEU ASP PRO GLN ALA ARG LEU ASP TYR GLY
SEQRES  15 D  592  TYR ASN SER TYR ASP GLN VAL THR GLN ALA GLY LYS ALA
SEQRES  16 D  592  ALA VAL ALA ARG PHE TYR GLY ARG ALA ALA ASP LYS SER
SEQRES  17 D  592  TYR PHE ILE GLY CYS SEP GLU GLY GLY ARG GLU GLY MET
SEQRES  18 D  592  MET LEU SER GLN ARG PHE PRO SER HIS TYR ASP GLY ILE
SEQRES  19 D  592  VAL ALA GLY ALA PRO GLY PHE GLN LEU PRO LYS ALA GLY
SEQRES  20 D  592  ILE SER GLY ALA TRP THR THR GLN SER LEU ALA PRO ALA
SEQRES  21 D  592  ALA VAL GLY LEU ASP ALA GLN GLY VAL PRO LEU ILE ASN
SEQRES  22 D  592  LYS SER PHE SER ASP ALA ASP LEU HIS LEU LEU SER GLN
SEQRES  23 D  592  ALA ILE LEU GLY THR CYS ASP ALA LEU ASP GLY LEU ALA
SEQRES  24 D  592  ASP GLY ILE VAL ASP ASN TYR ARG ALA CYS GLN ALA ALA
SEQRES  25 D  592  PHE ASP PRO ALA THR ALA ALA ASN PRO ALA ASN GLY GLN
SEQRES  26 D  592  ALA LEU GLN CYS VAL GLY ALA LYS THR ALA ASP CYS LEU
SEQRES  27 D  592  SER PRO VAL GLN VAL THR ALA ILE LYS ARG ALA MET ALA
SEQRES  28 D  592  GLY PRO VAL ASN SER ALA GLY THR PRO LEU TYR ASN ARG
SEQRES  29 D  592  TRP ALA TRP ASP ALA GLY MET SER GLY LEU SER GLY THR
SEQRES  30 D  592  THR TYR ASN GLN GLY TRP ARG SER TRP TRP LEU GLY SER
SEQRES  31 D  592  PHE ASN SER SER ALA ASN ASN ALA GLN ARG VAL SER GLY
SEQRES  32 D  592  PHE SER ALA ARG SER TRP LEU VAL ASP PHE ALA THR PRO
SEQRES  33 D  592  PRO GLU PRO MET PRO MET THR GLN VAL ALA ALA ARG MET
SEQRES  34 D  592  MET LYS PHE ASP PHE ASP ILE ASP PRO LEU LYS ILE TRP
SEQRES  35 D  592  ALA THR SER GLY GLN PHE THR GLN SER SER MET ASP TRP
SEQRES  36 D  592  HIS GLY ALA THR SER THR ASP LEU ALA ALA PHE ARG ASP
SEQRES  37 D  592  ARG GLY GLY LYS MET ILE LEU TYR HIS GLY MET SER ASP
SEQRES  38 D  592  ALA ALA PHE SER ALA LEU ASP THR ALA ASP TRP TYR GLU
SEQRES  39 D  592  ARG LEU GLY ALA ALA MET PRO GLY ALA ALA GLY PHE ALA
SEQRES  40 D  592  ARG LEU PHE LEU VAL PRO GLY MET ASN HIS CYS SER GLY
SEQRES  41 D  592  GLY PRO GLY THR ASP ARG PHE ASP MET LEU THR PRO LEU
SEQRES  42 D  592  VAL ALA TRP VAL GLU ARG GLY GLU ALA PRO ASP GLN ILE
SEQRES  43 D  592  SER ALA TRP SER GLY THR PRO GLY TYR PHE GLY VAL ALA
SEQRES  44 D  592  ALA ARG THR ARG PRO LEU CYS PRO TYR PRO GLN ILE ALA
SEQRES  45 D  592  ARG TYR LYS GLY SER GLY ASP ILE ASN THR GLU ALA ASN
SEQRES  46 D  592  PHE ALA CYS ALA ALA PRO PRO
SEQRES   1 E  592  MET GLU ASN LEU TYR PHE GLN GLY GLY GLY GLY SER THR
SEQRES   2 E  592  PRO LEU PRO LEU PRO GLN GLN GLN PRO PRO GLN GLN GLU
SEQRES   3 E  592  PRO PRO PRO PRO PRO VAL PRO LEU ALA SER ARG ALA ALA
SEQRES   4 E  592  CYS GLU ALA LEU LYS ASP GLY ASN GLY ASP MET VAL TRP
SEQRES   5 E  592  PRO ASN ALA ALA THR VAL VAL GLU VAL ALA ALA TRP ARG
SEQRES   6 E  592  ASP ALA ALA PRO ALA THR ALA SER ALA ALA ALA LEU PRO
SEQRES   7 E  592  GLU HIS CYS GLU VAL SER GLY ALA ILE ALA LYS ARG THR
SEQRES   8 E  592  GLY ILE ASP GLY TYR PRO TYR GLU ILE LYS PHE ARG LEU
SEQRES   9 E  592  ARG MET PRO ALA GLU TRP ASN GLY ARG PHE PHE MET GLU
SEQRES  10 E  592  GLY GLY SER GLY THR ASN GLY SER LEU SER ALA ALA THR
SEQRES  11 E  592  GLY SER ILE GLY GLY GLY GLN ILE ALA SER ALA LEU SER
SEQRES  12 E  592  ARG ASN PHE ALA VAL ILE ALA THR ASP GLY GLY HIS ASP
SEQRES  13 E  592  ASN ALA VAL ASN ASP ASN PRO ASP ALA LEU GLY THR VAL
SEQRES  14 E  592  ALA PHE GLY LEU ASP PRO GLN ALA ARG LEU ASP TYR GLY
SEQRES  15 E  592  TYR ASN SER TYR ASP GLN VAL THR GLN ALA GLY LYS ALA
SEQRES  16 E  592  ALA VAL ALA ARG PHE TYR GLY ARG ALA ALA ASP LYS SER
SEQRES  17 E  592  TYR PHE ILE GLY CYS SEP GLU GLY GLY ARG GLU GLY MET
SEQRES  18 E  592  MET LEU SER GLN ARG PHE PRO SER HIS TYR ASP GLY ILE
SEQRES  19 E  592  VAL ALA GLY ALA PRO GLY PHE GLN LEU PRO LYS ALA GLY
SEQRES  20 E  592  ILE SER GLY ALA TRP THR THR GLN SER LEU ALA PRO ALA
SEQRES  21 E  592  ALA VAL GLY LEU ASP ALA GLN GLY VAL PRO LEU ILE ASN
SEQRES  22 E  592  LYS SER PHE SER ASP ALA ASP LEU HIS LEU LEU SER GLN
SEQRES  23 E  592  ALA ILE LEU GLY THR CYS ASP ALA LEU ASP GLY LEU ALA
SEQRES  24 E  592  ASP GLY ILE VAL ASP ASN TYR ARG ALA CYS GLN ALA ALA
SEQRES  25 E  592  PHE ASP PRO ALA THR ALA ALA ASN PRO ALA ASN GLY GLN
SEQRES  26 E  592  ALA LEU GLN CYS VAL GLY ALA LYS THR ALA ASP CYS LEU
SEQRES  27 E  592  SER PRO VAL GLN VAL THR ALA ILE LYS ARG ALA MET ALA
SEQRES  28 E  592  GLY PRO VAL ASN SER ALA GLY THR PRO LEU TYR ASN ARG
SEQRES  29 E  592  TRP ALA TRP ASP ALA GLY MET SER GLY LEU SER GLY THR
SEQRES  30 E  592  THR TYR ASN GLN GLY TRP ARG SER TRP TRP LEU GLY SER
SEQRES  31 E  592  PHE ASN SER SER ALA ASN ASN ALA GLN ARG VAL SER GLY
SEQRES  32 E  592  PHE SER ALA ARG SER TRP LEU VAL ASP PHE ALA THR PRO
SEQRES  33 E  592  PRO GLU PRO MET PRO MET THR GLN VAL ALA ALA ARG MET
SEQRES  34 E  592  MET LYS PHE ASP PHE ASP ILE ASP PRO LEU LYS ILE TRP
SEQRES  35 E  592  ALA THR SER GLY GLN PHE THR GLN SER SER MET ASP TRP
SEQRES  36 E  592  HIS GLY ALA THR SER THR ASP LEU ALA ALA PHE ARG ASP
SEQRES  37 E  592  ARG GLY GLY LYS MET ILE LEU TYR HIS GLY MET SER ASP
SEQRES  38 E  592  ALA ALA PHE SER ALA LEU ASP THR ALA ASP TRP TYR GLU
SEQRES  39 E  592  ARG LEU GLY ALA ALA MET PRO GLY ALA ALA GLY PHE ALA
SEQRES  40 E  592  ARG LEU PHE LEU VAL PRO GLY MET ASN HIS CYS SER GLY
SEQRES  41 E  592  GLY PRO GLY THR ASP ARG PHE ASP MET LEU THR PRO LEU
SEQRES  42 E  592  VAL ALA TRP VAL GLU ARG GLY GLU ALA PRO ASP GLN ILE
SEQRES  43 E  592  SER ALA TRP SER GLY THR PRO GLY TYR PHE GLY VAL ALA
SEQRES  44 E  592  ALA ARG THR ARG PRO LEU CYS PRO TYR PRO GLN ILE ALA
SEQRES  45 E  592  ARG TYR LYS GLY SER GLY ASP ILE ASN THR GLU ALA ASN
SEQRES  46 E  592  PHE ALA CYS ALA ALA PRO PRO
SEQRES   1 F  592  MET GLU ASN LEU TYR PHE GLN GLY GLY GLY GLY SER THR
SEQRES   2 F  592  PRO LEU PRO LEU PRO GLN GLN GLN PRO PRO GLN GLN GLU
SEQRES   3 F  592  PRO PRO PRO PRO PRO VAL PRO LEU ALA SER ARG ALA ALA
SEQRES   4 F  592  CYS GLU ALA LEU LYS ASP GLY ASN GLY ASP MET VAL TRP
SEQRES   5 F  592  PRO ASN ALA ALA THR VAL VAL GLU VAL ALA ALA TRP ARG
SEQRES   6 F  592  ASP ALA ALA PRO ALA THR ALA SER ALA ALA ALA LEU PRO
SEQRES   7 F  592  GLU HIS CYS GLU VAL SER GLY ALA ILE ALA LYS ARG THR
SEQRES   8 F  592  GLY ILE ASP GLY TYR PRO TYR GLU ILE LYS PHE ARG LEU
SEQRES   9 F  592  ARG MET PRO ALA GLU TRP ASN GLY ARG PHE PHE MET GLU
SEQRES  10 F  592  GLY GLY SER GLY THR ASN GLY SER LEU SER ALA ALA THR
SEQRES  11 F  592  GLY SER ILE GLY GLY GLY GLN ILE ALA SER ALA LEU SER
SEQRES  12 F  592  ARG ASN PHE ALA VAL ILE ALA THR ASP GLY GLY HIS ASP
SEQRES  13 F  592  ASN ALA VAL ASN ASP ASN PRO ASP ALA LEU GLY THR VAL
SEQRES  14 F  592  ALA PHE GLY LEU ASP PRO GLN ALA ARG LEU ASP TYR GLY
SEQRES  15 F  592  TYR ASN SER TYR ASP GLN VAL THR GLN ALA GLY LYS ALA
SEQRES  16 F  592  ALA VAL ALA ARG PHE TYR GLY ARG ALA ALA ASP LYS SER
SEQRES  17 F  592  TYR PHE ILE GLY CYS SEP GLU GLY GLY ARG GLU GLY MET
SEQRES  18 F  592  MET LEU SER GLN ARG PHE PRO SER HIS TYR ASP GLY ILE
SEQRES  19 F  592  VAL ALA GLY ALA PRO GLY PHE GLN LEU PRO LYS ALA GLY
SEQRES  20 F  592  ILE SER GLY ALA TRP THR THR GLN SER LEU ALA PRO ALA
SEQRES  21 F  592  ALA VAL GLY LEU ASP ALA GLN GLY VAL PRO LEU ILE ASN
SEQRES  22 F  592  LYS SER PHE SER ASP ALA ASP LEU HIS LEU LEU SER GLN
SEQRES  23 F  592  ALA ILE LEU GLY THR CYS ASP ALA LEU ASP GLY LEU ALA
SEQRES  24 F  592  ASP GLY ILE VAL ASP ASN TYR ARG ALA CYS GLN ALA ALA
SEQRES  25 F  592  PHE ASP PRO ALA THR ALA ALA ASN PRO ALA ASN GLY GLN
SEQRES  26 F  592  ALA LEU GLN CYS VAL GLY ALA LYS THR ALA ASP CYS LEU
SEQRES  27 F  592  SER PRO VAL GLN VAL THR ALA ILE LYS ARG ALA MET ALA
SEQRES  28 F  592  GLY PRO VAL ASN SER ALA GLY THR PRO LEU TYR ASN ARG
SEQRES  29 F  592  TRP ALA TRP ASP ALA GLY MET SER GLY LEU SER GLY THR
SEQRES  30 F  592  THR TYR ASN GLN GLY TRP ARG SER TRP TRP LEU GLY SER
SEQRES  31 F  592  PHE ASN SER SER ALA ASN ASN ALA GLN ARG VAL SER GLY
SEQRES  32 F  592  PHE SER ALA ARG SER TRP LEU VAL ASP PHE ALA THR PRO
SEQRES  33 F  592  PRO GLU PRO MET PRO MET THR GLN VAL ALA ALA ARG MET
SEQRES  34 F  592  MET LYS PHE ASP PHE ASP ILE ASP PRO LEU LYS ILE TRP
SEQRES  35 F  592  ALA THR SER GLY GLN PHE THR GLN SER SER MET ASP TRP
SEQRES  36 F  592  HIS GLY ALA THR SER THR ASP LEU ALA ALA PHE ARG ASP
SEQRES  37 F  592  ARG GLY GLY LYS MET ILE LEU TYR HIS GLY MET SER ASP
SEQRES  38 F  592  ALA ALA PHE SER ALA LEU ASP THR ALA ASP TRP TYR GLU
SEQRES  39 F  592  ARG LEU GLY ALA ALA MET PRO GLY ALA ALA GLY PHE ALA
SEQRES  40 F  592  ARG LEU PHE LEU VAL PRO GLY MET ASN HIS CYS SER GLY
SEQRES  41 F  592  GLY PRO GLY THR ASP ARG PHE ASP MET LEU THR PRO LEU
SEQRES  42 F  592  VAL ALA TRP VAL GLU ARG GLY GLU ALA PRO ASP GLN ILE
SEQRES  43 F  592  SER ALA TRP SER GLY THR PRO GLY TYR PHE GLY VAL ALA
SEQRES  44 F  592  ALA ARG THR ARG PRO LEU CYS PRO TYR PRO GLN ILE ALA
SEQRES  45 F  592  ARG TYR LYS GLY SER GLY ASP ILE ASN THR GLU ALA ASN
SEQRES  46 F  592  PHE ALA CYS ALA ALA PRO PRO
MODRES 8EKG SEP A  225  SER  MODIFIED RESIDUE
MODRES 8EKG SEP B  225  SER  MODIFIED RESIDUE
MODRES 8EKG SEP C  225  SER  MODIFIED RESIDUE
MODRES 8EKG SEP D  225  SER  MODIFIED RESIDUE
MODRES 8EKG SEP E  225  SER  MODIFIED RESIDUE
MODRES 8EKG SEP F  225  SER  MODIFIED RESIDUE
HET    SEP  A 225      10
HET    SEP  B 225      10
HET    SEP  C 225      10
HET    SEP  D 225      10
HET    SEP  E 225      10
HET    SEP  F 225      10
HET     CA  A 701       1
HET    PEG  A 702       7
HET    EDO  A 703       4
HET     CA  B 701       1
HET    SO4  B 702       5
HET    SO4  B 703       5
HET    EDO  B 704       4
HET    EDO  B 705       4
HET    EDO  B 706       4
HET    EDO  B 707       4
HET    EDO  B 708       4
HET    EDO  B 709       4
HET     CA  C 701       1
HET    EDO  C 702       4
HET     CA  D 701       1
HET    EDO  D 702       4
HET    EDO  D 703       4
HET     CA  E 701       1
HET    SO4  E 702       5
HET    SO4  E 703       5
HET    EDO  E 704       4
HET     CA  F 701       1
HETNAM     SEP PHOSPHOSERINE
HETNAM      CA CALCIUM ION
HETNAM     PEG DI(HYDROXYETHYL)ETHER
HETNAM     EDO 1,2-ETHANEDIOL
HETNAM     SO4 SULFATE ION
HETSYN     SEP PHOSPHONOSERINE
HETSYN     EDO ETHYLENE GLYCOL
FORMUL   1  SEP    6(C3 H8 N O6 P)
FORMUL   7   CA    6(CA 2+)
FORMUL   8  PEG    C4 H10 O3
FORMUL   9  EDO    11(C2 H6 O2)
FORMUL  11  SO4    4(O4 S 2-)
FORMUL  29  HOH   *403(H2 O)
HELIX    1 AA1 SER A   47  ALA A   53  1                                   7
HELIX    2 AA2 ALA A  152  ASN A  156  5                                   5
HELIX    3 AA3 LEU A  177  LEU A  184  5                                   8
HELIX    4 AA4 ASP A  185  TYR A  194  1                                  10
HELIX    5 AA5 TYR A  194  GLY A  213  1                                  20
HELIX    6 AA6 SEP A  225  PHE A  238  1                                  14
HELIX    7 AA7 GLN A  253  PRO A  255  5                                   3
HELIX    8 AA8 LYS A  256  ALA A  269  1                                  14
HELIX    9 AA9 PRO A  270  ALA A  272  5                                   3
HELIX   10 AB1 LEU A  282  SER A  286  5                                   5
HELIX   11 AB2 SER A  288  ASP A  304  1                                  17
HELIX   12 AB3 ALA A  305  GLY A  308  5                                   4
HELIX   13 AB4 ASN A  316  PHE A  324  1                                   9
HELIX   14 AB5 SER A  350  GLY A  363  1                                  14
HELIX   15 AB6 ASP A  379  SER A  383  5                                   5
HELIX   16 AB7 TRP A  394  LEU A  399  1                                   6
HELIX   17 AB8 GLY A  414  ASP A  423  1                                  10
HELIX   18 AB9 PRO A  432  THR A  434  5                                   3
HELIX   19 AC1 GLN A  435  LYS A  442  1                                   8
HELIX   20 AC2 ILE A  447  TRP A  453  5                                   7
HELIX   21 AC3 SER A  462  HIS A  467  1                                   6
HELIX   22 AC4 LEU A  474  ARG A  480  1                                   7
HELIX   23 AC5 SER A  496  MET A  511  1                                  16
HELIX   24 AC6 GLY A  513  GLY A  516  5                                   4
HELIX   25 AC7 MET A  540  GLU A  549  1                                  10
HELIX   26 AC8 THR A  563  PHE A  567  5                                   5
HELIX   27 AC9 THR A  593  ALA A  595  5                                   3
HELIX   28 AD1 ARG B   48  ALA B   53  1                                   6
HELIX   29 AD2 LEU B   54  ASP B   56  5                                   3
HELIX   30 AD3 ALA B  152  ASN B  156  5                                   5
HELIX   31 AD4 LEU B  177  LEU B  184  5                                   8
HELIX   32 AD5 ASP B  185  TYR B  194  1                                  10
HELIX   33 AD6 TYR B  194  GLY B  213  1                                  20
HELIX   34 AD7 SEP B  225  PHE B  238  1                                  14
HELIX   35 AD8 GLN B  253  PRO B  255  5                                   3
HELIX   36 AD9 LYS B  256  ALA B  269  1                                  14
HELIX   37 AE1 LEU B  282  SER B  286  5                                   5
HELIX   38 AE2 SER B  288  ASP B  304  1                                  17
HELIX   39 AE3 ALA B  305  GLY B  308  5                                   4
HELIX   40 AE4 ASN B  316  ALA B  322  1                                   7
HELIX   41 AE5 SER B  350  GLY B  363  1                                  14
HELIX   42 AE6 ASP B  379  SER B  383  5                                   5
HELIX   43 AE7 TRP B  394  LEU B  399  1                                   6
HELIX   44 AE8 GLY B  414  ASP B  423  1                                  10
HELIX   45 AE9 PRO B  432  THR B  434  5                                   3
HELIX   46 AF1 GLN B  435  LYS B  442  1                                   8
HELIX   47 AF2 ASP B  448  TRP B  453  5                                   6
HELIX   48 AF3 SER B  462  GLY B  468  1                                   7
HELIX   49 AF4 LEU B  474  ARG B  480  1                                   7
HELIX   50 AF5 SER B  496  MET B  511  1                                  16
HELIX   51 AF6 GLY B  513  GLY B  516  5                                   4
HELIX   52 AF7 MET B  540  GLY B  551  1                                  12
HELIX   53 AF8 THR B  563  GLY B  568  5                                   6
HELIX   54 AF9 THR B  593  ALA B  595  5                                   3
HELIX   55 AG1 ARG C   48  ALA C   53  1                                   6
HELIX   56 AG2 ALA C  152  ASN C  156  5                                   5
HELIX   57 AG3 LEU C  177  LEU C  184  5                                   8
HELIX   58 AG4 ASP C  185  TYR C  194  1                                  10
HELIX   59 AG5 TYR C  194  GLY C  213  1                                  20
HELIX   60 AG6 SEP C  225  PHE C  238  1                                  14
HELIX   61 AG7 GLN C  253  PRO C  255  5                                   3
HELIX   62 AG8 LYS C  256  ALA C  269  1                                  14
HELIX   63 AG9 LEU C  282  SER C  286  5                                   5
HELIX   64 AH1 SER C  288  ASP C  304  1                                  17
HELIX   65 AH2 ALA C  305  GLY C  308  5                                   4
HELIX   66 AH3 ASN C  316  PHE C  324  1                                   9
HELIX   67 AH4 SER C  350  GLY C  363  1                                  14
HELIX   68 AH5 ASP C  379  SER C  383  5                                   5
HELIX   69 AH6 TRP C  394  LEU C  399  1                                   6
HELIX   70 AH7 GLY C  414  PHE C  424  1                                  11
HELIX   71 AH8 PRO C  432  THR C  434  5                                   3
HELIX   72 AH9 GLN C  435  LYS C  442  1                                   8
HELIX   73 AI1 ILE C  447  TRP C  453  5                                   7
HELIX   74 AI2 SER C  462  HIS C  467  1                                   6
HELIX   75 AI3 LEU C  474  ARG C  480  1                                   7
HELIX   76 AI4 SER C  496  MET C  511  1                                  16
HELIX   77 AI5 GLY C  513  GLY C  516  5                                   4
HELIX   78 AI6 MET C  540  GLU C  549  1                                  10
HELIX   79 AI7 THR C  563  GLY C  568  5                                   6
HELIX   80 AI8 THR C  593  ALA C  595  5                                   3
HELIX   81 AI9 ARG D   48  ALA D   53  1                                   6
HELIX   82 AJ1 ALA D  152  ASN D  156  5                                   5
HELIX   83 AJ2 ASN D  173  LEU D  184  5                                  12
HELIX   84 AJ3 ASP D  185  TYR D  194  1                                  10
HELIX   85 AJ4 TYR D  194  GLY D  213  1                                  20
HELIX   86 AJ5 SEP D  225  PHE D  238  1                                  14
HELIX   87 AJ6 GLN D  253  PRO D  255  5                                   3
HELIX   88 AJ7 LYS D  256  ALA D  269  1                                  14
HELIX   89 AJ8 PRO D  270  ALA D  272  5                                   3
HELIX   90 AJ9 LEU D  282  SER D  286  5                                   5
HELIX   91 AK1 SER D  288  ASP D  304  1                                  17
HELIX   92 AK2 ALA D  305  GLY D  308  5                                   4
HELIX   93 AK3 ASN D  316  PHE D  324  1                                   9
HELIX   94 AK4 SER D  350  GLY D  363  1                                  14
HELIX   95 AK5 ASP D  379  SER D  383  5                                   5
HELIX   96 AK6 TRP D  394  LEU D  399  1                                   6
HELIX   97 AK7 ALA D  409  GLY D  414  1                                   6
HELIX   98 AK8 GLY D  414  PHE D  424  1                                  11
HELIX   99 AK9 PRO D  432  THR D  434  5                                   3
HELIX  100 AL1 GLN D  435  LYS D  442  1                                   8
HELIX  101 AL2 ASP D  448  TRP D  453  5                                   6
HELIX  102 AL3 SER D  462  GLY D  468  1                                   7
HELIX  103 AL4 LEU D  474  ARG D  480  1                                   7
HELIX  104 AL5 SER D  496  MET D  511  1                                  16
HELIX  105 AL6 GLY D  513  GLY D  516  5                                   4
HELIX  106 AL7 MET D  540  ARG D  550  1                                  11
HELIX  107 AL8 THR D  563  PHE D  567  5                                   5
HELIX  108 AL9 SER E   47  ALA E   53  1                                   7
HELIX  109 AM1 LEU E   54  ASP E   56  5                                   3
HELIX  110 AM2 ALA E  152  ASN E  156  5                                   5
HELIX  111 AM3 ASN E  173  LEU E  177  5                                   5
HELIX  112 AM4 VAL E  180  LEU E  184  5                                   5
HELIX  113 AM5 ASP E  185  TYR E  194  1                                  10
HELIX  114 AM6 TYR E  194  GLY E  213  1                                  20
HELIX  115 AM7 SEP E  225  PHE E  238  1                                  14
HELIX  116 AM8 GLN E  253  PRO E  255  5                                   3
HELIX  117 AM9 LYS E  256  ALA E  269  1                                  14
HELIX  118 AN1 PRO E  270  ALA E  272  5                                   3
HELIX  119 AN2 LEU E  282  SER E  286  5                                   5
HELIX  120 AN3 SER E  288  ASP E  304  1                                  17
HELIX  121 AN4 ALA E  305  GLY E  308  5                                   4
HELIX  122 AN5 ASN E  316  PHE E  324  1                                   9
HELIX  123 AN6 SER E  350  GLY E  363  1                                  14
HELIX  124 AN7 ASP E  379  SER E  383  5                                   5
HELIX  125 AN8 TRP E  394  LEU E  399  1                                   6
HELIX  126 AN9 GLY E  414  ASP E  423  1                                  10
HELIX  127 AO1 GLN E  435  LYS E  442  1                                   8
HELIX  128 AO2 ASP E  448  TRP E  453  5                                   6
HELIX  129 AO3 SER E  462  GLY E  468  1                                   7
HELIX  130 AO4 LEU E  474  ARG E  480  1                                   7
HELIX  131 AO5 SER E  496  MET E  511  1                                  16
HELIX  132 AO6 GLY E  513  GLY E  516  5                                   4
HELIX  133 AO7 MET E  540  GLU E  549  1                                  10
HELIX  134 AO8 THR E  563  GLY E  568  5                                   6
HELIX  135 AO9 THR E  593  ALA E  595  5                                   3
HELIX  136 AP1 ARG F   48  ALA F   53  1                                   6
HELIX  137 AP2 ASN F  173  LEU F  184  5                                  12
HELIX  138 AP3 ASP F  185  TYR F  194  1                                  10
HELIX  139 AP4 TYR F  194  GLY F  213  1                                  20
HELIX  140 AP5 SEP F  225  PHE F  238  1                                  14
HELIX  141 AP6 GLN F  253  PRO F  255  5                                   3
HELIX  142 AP7 LYS F  256  ALA F  269  1                                  14
HELIX  143 AP8 ILE F  283  PHE F  287  5                                   5
HELIX  144 AP9 SER F  288  ASP F  304  1                                  17
HELIX  145 AQ1 ALA F  305  GLY F  308  5                                   4
HELIX  146 AQ2 ASN F  316  PHE F  324  1                                   9
HELIX  147 AQ3 SER F  350  GLY F  363  1                                  14
HELIX  148 AQ4 ASP F  379  SER F  383  5                                   5
HELIX  149 AQ5 TRP F  394  LEU F  399  1                                   6
HELIX  150 AQ6 ALA F  409  GLY F  414  1                                   6
HELIX  151 AQ7 GLY F  414  ASP F  423  1                                  10
HELIX  152 AQ8 PRO F  432  THR F  434  5                                   3
HELIX  153 AQ9 GLN F  435  MET F  440  1                                   6
HELIX  154 AR1 ASP F  448  TRP F  453  5                                   6
HELIX  155 AR2 SER F  462  HIS F  467  1                                   6
HELIX  156 AR3 LEU F  474  ARG F  480  1                                   7
HELIX  157 AR4 SER F  496  MET F  511  1                                  16
HELIX  158 AR5 GLY F  513  GLY F  516  5                                   4
HELIX  159 AR6 MET F  540  GLY F  551  1                                  12
HELIX  160 AR7 THR F  563  GLY F  568  5                                   6
SHEET    1 AA1 9 THR A  68  ARG A  76  0
SHEET    2 AA1 9 HIS A  91  THR A 102 -1  O  HIS A  91   N  ARG A  76
SHEET    3 AA1 9 PRO A 108  PRO A 118 -1  O  LEU A 115   N  VAL A  94
SHEET    4 AA1 9 ALA A 158  THR A 162 -1  O  VAL A 159   N  ARG A 116
SHEET    5 AA1 9 ARG A 124  GLU A 128  1  N  PHE A 126   O  ALA A 158
SHEET    6 AA1 9 LYS A 218  CYS A 224  1  O  LYS A 218   N  PHE A 125
SHEET    7 AA1 9 GLY A 244  GLY A 248  1  O  GLY A 248   N  GLY A 223
SHEET    8 AA1 9 LYS A 483  GLY A 489  1  O  ILE A 485   N  ILE A 245
SHEET    9 AA1 9 ALA A 518  VAL A 523  1  O  PHE A 521   N  LEU A 486
SHEET    1 AA2 2 LEU A 385  SER A 386  0
SHEET    2 AA2 2 THR A 389  TYR A 390 -1  O  THR A 389   N  SER A 386
SHEET    1 AA3 3 ARG A 537  PHE A 538  0
SHEET    2 AA3 3 ILE A 557  TRP A 560 -1  O  TRP A 560   N  ARG A 537
SHEET    3 AA3 3 THR A 573  LEU A 576 -1  O  LEU A 576   N  ILE A 557
SHEET    1 AA4 2 ILE A 582  TYR A 585  0
SHEET    2 AA4 2 PHE A 597  ALA A 600 -1  O  ALA A 598   N  ARG A 584
SHEET    1 AA5 9 THR B  68  ARG B  76  0
SHEET    2 AA5 9 HIS B  91  THR B 102 -1  O  ALA B  97   N  VAL B  69
SHEET    3 AA5 9 PRO B 108  PRO B 118 -1  O  ILE B 111   N  ILE B  98
SHEET    4 AA5 9 ALA B 158  THR B 162 -1  O  VAL B 159   N  ARG B 116
SHEET    5 AA5 9 ARG B 124  GLU B 128  1  N  PHE B 126   O  ALA B 158
SHEET    6 AA5 9 LYS B 218  CYS B 224  1  O  TYR B 220   N  PHE B 125
SHEET    7 AA5 9 GLY B 244  GLY B 248  1  O  GLY B 248   N  GLY B 223
SHEET    8 AA5 9 LYS B 483  GLY B 489  1  O  ILE B 485   N  ILE B 245
SHEET    9 AA5 9 ALA B 518  VAL B 523  1  O  PHE B 521   N  LEU B 486
SHEET    1 AA6 2 ALA B 330  ASN B 331  0
SHEET    2 AA6 2 GLN B 336  ALA B 337 -1  O  GLN B 336   N  ASN B 331
SHEET    1 AA7 2 LEU B 385  SER B 386  0
SHEET    2 AA7 2 THR B 389  TYR B 390 -1  O  THR B 389   N  SER B 386
SHEET    1 AA8 3 ARG B 537  PHE B 538  0
SHEET    2 AA8 3 ILE B 557  TRP B 560 -1  O  TRP B 560   N  ARG B 537
SHEET    3 AA8 3 THR B 573  LEU B 576 -1  O  ARG B 574   N  ALA B 559
SHEET    1 AA9 2 ILE B 582  TYR B 585  0
SHEET    2 AA9 2 PHE B 597  ALA B 600 -1  O  ALA B 600   N  ILE B 582
SHEET    1 AB1 9 THR C  68  ARG C  76  0
SHEET    2 AB1 9 HIS C  91  THR C 102 -1  O  ALA C  97   N  VAL C  69
SHEET    3 AB1 9 PRO C 108  PRO C 118 -1  O  LEU C 115   N  VAL C  94
SHEET    4 AB1 9 ALA C 158  THR C 162 -1  O  VAL C 159   N  ARG C 116
SHEET    5 AB1 9 ARG C 124  GLU C 128  1  N  PHE C 126   O  ALA C 158
SHEET    6 AB1 9 LYS C 218  CYS C 224  1  O  LYS C 218   N  PHE C 125
SHEET    7 AB1 9 GLY C 244  GLY C 248  1  O  GLY C 244   N  PHE C 221
SHEET    8 AB1 9 LYS C 483  GLY C 489  1  O  ILE C 485   N  ILE C 245
SHEET    9 AB1 9 ALA C 518  VAL C 523  1  O  VAL C 523   N  HIS C 488
SHEET    1 AB2 2 LEU C 385  SER C 386  0
SHEET    2 AB2 2 THR C 389  TYR C 390 -1  O  THR C 389   N  SER C 386
SHEET    1 AB3 2 ILE C 557  TRP C 560  0
SHEET    2 AB3 2 THR C 573  LEU C 576 -1  O  LEU C 576   N  ILE C 557
SHEET    1 AB4 2 ILE C 582  TYR C 585  0
SHEET    2 AB4 2 PHE C 597  ALA C 600 -1  O  ALA C 598   N  ARG C 584
SHEET    1 AB5 9 THR D  68  ARG D  76  0
SHEET    2 AB5 9 HIS D  91  THR D 102 -1  O  GLU D  93   N  ALA D  74
SHEET    3 AB5 9 PRO D 108  PRO D 118 -1  O  LEU D 115   N  VAL D  94
SHEET    4 AB5 9 ALA D 158  THR D 162 -1  O  VAL D 159   N  ARG D 116
SHEET    5 AB5 9 ARG D 124  GLU D 128  1  N  PHE D 126   O  ALA D 158
SHEET    6 AB5 9 LYS D 218  CYS D 224  1  O  TYR D 220   N  PHE D 125
SHEET    7 AB5 9 GLY D 244  GLY D 248  1  O  VAL D 246   N  PHE D 221
SHEET    8 AB5 9 LYS D 483  GLY D 489  1  O  ILE D 485   N  ILE D 245
SHEET    9 AB5 9 ALA D 518  VAL D 523  1  O  ARG D 519   N  LEU D 486
SHEET    1 AB6 2 LEU D 385  SER D 386  0
SHEET    2 AB6 2 THR D 389  TYR D 390 -1  O  THR D 389   N  SER D 386
SHEET    1 AB7 2 ILE D 557  TRP D 560  0
SHEET    2 AB7 2 THR D 573  LEU D 576 -1  O  LEU D 576   N  ILE D 557
SHEET    1 AB8 2 ILE D 582  TYR D 585  0
SHEET    2 AB8 2 PHE D 597  ALA D 600 -1  O  ALA D 598   N  ARG D 584
SHEET    1 AB9 9 THR E  68  ARG E  76  0
SHEET    2 AB9 9 HIS E  91  THR E 102 -1  O  HIS E  91   N  ARG E  76
SHEET    3 AB9 9 PRO E 108  PRO E 118 -1  O  LEU E 115   N  VAL E  94
SHEET    4 AB9 9 ALA E 158  THR E 162 -1  O  VAL E 159   N  ARG E 116
SHEET    5 AB9 9 ARG E 124  GLU E 128  1  N  PHE E 126   O  ALA E 158
SHEET    6 AB9 9 LYS E 218  CYS E 224  1  O  TYR E 220   N  PHE E 125
SHEET    7 AB9 9 GLY E 244  GLY E 248  1  O  GLY E 248   N  GLY E 223
SHEET    8 AB9 9 LYS E 483  GLY E 489  1  O  ILE E 485   N  ILE E 245
SHEET    9 AB9 9 ALA E 518  VAL E 523  1  O  VAL E 523   N  HIS E 488
SHEET    1 AC1 2 LEU E 385  SER E 386  0
SHEET    2 AC1 2 THR E 389  TYR E 390 -1  O  THR E 389   N  SER E 386
SHEET    1 AC2 3 ARG E 537  PHE E 538  0
SHEET    2 AC2 3 ILE E 557  TRP E 560 -1  O  TRP E 560   N  ARG E 537
SHEET    3 AC2 3 THR E 573  LEU E 576 -1  O  LEU E 576   N  ILE E 557
SHEET    1 AC3 2 ILE E 582  TYR E 585  0
SHEET    2 AC3 2 PHE E 597  ALA E 600 -1  O  ALA E 598   N  ARG E 584
SHEET    1 AC4 9 THR F  68  ARG F  76  0
SHEET    2 AC4 9 HIS F  91  THR F 102 -1  O  ALA F  97   N  VAL F  69
SHEET    3 AC4 9 PRO F 108  PRO F 118 -1  O  TYR F 109   N  ARG F 101
SHEET    4 AC4 9 ALA F 158  THR F 162 -1  O  VAL F 159   N  ARG F 116
SHEET    5 AC4 9 ARG F 124  GLU F 128  1  N  PHE F 126   O  ALA F 158
SHEET    6 AC4 9 LYS F 218  CYS F 224  1  O  LYS F 218   N  PHE F 125
SHEET    7 AC4 9 GLY F 244  GLY F 248  1  O  GLY F 248   N  GLY F 223
SHEET    8 AC4 9 LYS F 483  GLY F 489  1  O  ILE F 485   N  ILE F 245
SHEET    9 AC4 9 ALA F 518  VAL F 523  1  O  VAL F 523   N  HIS F 488
SHEET    1 AC5 2 LEU F 275  ASP F 276  0
SHEET    2 AC5 2 VAL F 280  PRO F 281 -1  O  VAL F 280   N  ASP F 276
SHEET    1 AC6 2 LEU F 385  SER F 386  0
SHEET    2 AC6 2 THR F 389  TYR F 390 -1  O  THR F 389   N  SER F 386
SHEET    1 AC7 3 ARG F 537  PHE F 538  0
SHEET    2 AC7 3 ILE F 557  TRP F 560 -1  O  TRP F 560   N  ARG F 537
SHEET    3 AC7 3 THR F 573  LEU F 576 -1  O  LEU F 576   N  ILE F 557
SHEET    1 AC8 2 ILE F 582  TYR F 585  0
SHEET    2 AC8 2 PHE F 597  ALA F 600 -1  O  ALA F 598   N  ARG F 584
SSBOND   1 CYS A   51    CYS A   92                          1555   1555  2.03
SSBOND   2 CYS A  224    CYS A  529                          1555   1555  2.03
SSBOND   3 CYS A  303    CYS A  320                          1555   1555  2.03
SSBOND   4 CYS A  340    CYS A  348                          1555   1555  2.03
SSBOND   5 CYS A  577    CYS A  599                          1555   1555  2.03
SSBOND   6 CYS B   51    CYS B   92                          1555   1555  2.03
SSBOND   7 CYS B  224    CYS B  529                          1555   1555  2.03
SSBOND   8 CYS B  303    CYS B  320                          1555   1555  2.03
SSBOND   9 CYS B  340    CYS B  348                          1555   1555  2.03
SSBOND  10 CYS B  577    CYS B  599                          1555   1555  2.03
SSBOND  11 CYS C   51    CYS C   92                          1555   1555  2.03
SSBOND  12 CYS C  224    CYS C  529                          1555   1555  2.03
SSBOND  13 CYS C  303    CYS C  320                          1555   1555  2.03
SSBOND  14 CYS C  340    CYS C  348                          1555   1555  2.03
SSBOND  15 CYS C  577    CYS C  599                          1555   1555  2.03
SSBOND  16 CYS D   51    CYS D   92                          1555   1555  2.03
SSBOND  17 CYS D  224    CYS D  529                          1555   1555  2.03
SSBOND  18 CYS D  303    CYS D  320                          1555   1555  2.03
SSBOND  19 CYS D  340    CYS D  348                          1555   1555  2.03
SSBOND  20 CYS D  577    CYS D  599                          1555   1555  2.03
SSBOND  21 CYS E   51    CYS E   92                          1555   1555  2.03
SSBOND  22 CYS E  224    CYS E  529                          1555   1555  2.03
SSBOND  23 CYS E  303    CYS E  320                          1555   1555  2.03
SSBOND  24 CYS E  340    CYS E  348                          1555   1555  2.03
SSBOND  25 CYS E  577    CYS E  599                          1555   1555  2.03
SSBOND  26 CYS F   51    CYS F   92                          1555   1555  2.03
SSBOND  27 CYS F  224    CYS F  529                          1555   1555  2.03
SSBOND  28 CYS F  303    CYS F  320                          1555   1555  2.03
SSBOND  29 CYS F  340    CYS F  348                          1555   1555  2.03
SSBOND  30 CYS F  577    CYS F  599                          1555   1555  2.03
LINK         C   CYS A 224                 N   SEP A 225     1555   1555  1.33
LINK         C   SEP A 225                 N   GLU A 226     1555   1555  1.33
LINK         C   CYS B 224                 N   SEP B 225     1555   1555  1.33
LINK         C   SEP B 225                 N   GLU B 226     1555   1555  1.32
LINK         C   CYS C 224                 N   SEP C 225     1555   1555  1.33
LINK         C   SEP C 225                 N   GLU C 226     1555   1555  1.33
LINK         C   CYS D 224                 N   SEP D 225     1555   1555  1.33
LINK         C   SEP D 225                 N   GLU D 226     1555   1555  1.33
LINK         C   CYS E 224                 N   SEP E 225     1555   1555  1.33
LINK         C   SEP E 225                 N   GLU E 226     1555   1555  1.33
LINK         C   CYS F 224                 N   SEP F 225     1555   1555  1.33
LINK         C   SEP F 225                 N   GLU F 226     1555   1555  1.33
LINK         O   ASP A 304                CA    CA A 701     1555   1555  2.75
LINK         OD1 ASP A 304                CA    CA A 701     1555   1555  2.56
LINK         OD1 ASP A 307                CA    CA A 701     1555   1555  2.62
LINK         OD2 ASP A 307                CA    CA A 701     1555   1555  2.79
LINK         O   LEU A 309                CA    CA A 701     1555   1555  2.74
LINK         OD1 ASP A 311                CA    CA A 701     1555   1555  2.37
LINK         O   ILE A 313                CA    CA A 701     1555   1555  2.31
LINK         O   ASP B 304                CA    CA B 701     1555   1555  2.59
LINK         OD1 ASP B 304                CA    CA B 701     1555   1555  2.50
LINK         OD1 ASP B 307                CA    CA B 701     1555   1555  2.87
LINK         OD2 ASP B 307                CA    CA B 701     1555   1555  2.46
LINK         O   LEU B 309                CA    CA B 701     1555   1555  2.44
LINK         OD1 ASP B 311                CA    CA B 701     1555   1555  2.30
LINK         O   ILE B 313                CA    CA B 701     1555   1555  2.31
LINK         O   ASP C 304                CA    CA C 701     1555   1555  2.47
LINK         OD1 ASP C 304                CA    CA C 701     1555   1555  2.63
LINK         OD1 ASP C 307                CA    CA C 701     1555   1555  2.37
LINK         OD2 ASP C 307                CA    CA C 701     1555   1555  3.03
LINK         O   LEU C 309                CA    CA C 701     1555   1555  2.24
LINK         OD1 ASP C 311                CA    CA C 701     1555   1555  2.51
LINK         O   ILE C 313                CA    CA C 701     1555   1555  2.67
LINK         O   ASP D 304                CA    CA D 701     1555   1555  2.98
LINK         OD1 ASP D 304                CA    CA D 701     1555   1555  2.80
LINK         OD1 ASP D 307                CA    CA D 701     1555   1555  2.35
LINK         OD2 ASP D 307                CA    CA D 701     1555   1555  2.58
LINK         O   LEU D 309                CA    CA D 701     1555   1555  2.41
LINK         OD1 ASP D 311                CA    CA D 701     1555   1555  2.28
LINK         O   ILE D 313                CA    CA D 701     1555   1555  2.37
LINK         O   ASP E 304                CA    CA E 701     1555   1555  2.83
LINK         OD1 ASP E 304                CA    CA E 701     1555   1555  2.57
LINK         OD1 ASP E 307                CA    CA E 701     1555   1555  2.36
LINK         OD2 ASP E 307                CA    CA E 701     1555   1555  2.78
LINK         O   LEU E 309                CA    CA E 701     1555   1555  2.34
LINK         OD1 ASP E 311                CA    CA E 701     1555   1555  2.33
LINK         O   ILE E 313                CA    CA E 701     1555   1555  2.60
LINK         O   ASP F 304                CA    CA F 701     1555   1555  2.75
LINK         OD1 ASP F 304                CA    CA F 701     1555   1555  2.76
LINK         OD1 ASP F 307                CA    CA F 701     1555   1555  2.54
LINK         OD2 ASP F 307                CA    CA F 701     1555   1555  2.50
LINK         O   LEU F 309                CA    CA F 701     1555   1555  2.34
LINK         OD1 ASP F 311                CA    CA F 701     1555   1555  2.34
LINK         O   ILE F 313                CA    CA F 701     1555   1555  2.46
CISPEP   1 THR A  426    PRO A  427          0        -1.44
CISPEP   2 TYR A  579    PRO A  580          0         2.13
CISPEP   3 THR B  426    PRO B  427          0        -0.68
CISPEP   4 TYR B  579    PRO B  580          0         0.31
CISPEP   5 THR C  426    PRO C  427          0        -1.06
CISPEP   6 TYR C  579    PRO C  580          0         2.05
CISPEP   7 THR D  426    PRO D  427          0        -0.84
CISPEP   8 TYR D  579    PRO D  580          0         2.50
CISPEP   9 THR E  426    PRO E  427          0        -0.32
CISPEP  10 TYR E  579    PRO E  580          0        -1.95
CISPEP  11 THR F  426    PRO F  427          0        -2.95
CISPEP  12 TYR F  579    PRO F  580          0         1.58
CRYST1   63.967  120.514  126.290  90.44  95.15  90.20 P 1           6
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.015633  0.000055  0.001409        0.00000
SCALE2      0.000000  0.008298  0.000067        0.00000
SCALE3      0.000000  0.000000  0.007951        0.00000
TER    4129      PRO A 603
TER    8253      PRO B 603
TER   12377      PRO C 603
TER   16501      PRO D 603
TER   20630      PRO E 603
TER   24754      PRO F 603
MASTER      887    0   28  160   98    0    0    625228    6  257  276
END