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HEADER    HYDROLASE                               12-OCT-22   8ERL
TITLE     CRYOEM STRUCTURE OF LIPOPROTEIN LIPASE DIMER
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: LIPOPROTEIN LIPASE;
COMPND   3 CHAIN: A, B;
COMPND   4 SYNONYM: LPL;
COMPND   5 EC: 3.1.1.34
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: BOS TAURUS;
SOURCE   3 ORGANISM_COMMON: CATTLE;
SOURCE   4 ORGANISM_TAXID: 9913
KEYWDS    DIMER, LIPASE, HYDROLASE
EXPDTA    ELECTRON MICROSCOPY
AUTHOR    K.H.GUNN,S.B.NEHER
REVDAT   1   03-MAY-23 8ERL    0
JRNL        AUTH   K.H.GUNN,S.B.NEHER
JRNL        TITL   ACTIVE LIPOPROTEIN LIPASE DIMER REVEALED BY CRYO-ELECTRON
JRNL        TITL 2 MICROSCOPY
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   2
REMARK   2 RESOLUTION.    3.90 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   SOFTWARE PACKAGES      : CRYOSPARC, CRYOSPARC, CRYOSPARC
REMARK   3   RECONSTRUCTION SCHEMA  : NULL
REMARK   3
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT
REMARK   3   PDB ENTRY                    : NULL
REMARK   3   REFINEMENT SPACE             : NULL
REMARK   3   REFINEMENT PROTOCOL          : NULL
REMARK   3   REFINEMENT TARGET            : NULL
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL
REMARK   3
REMARK   3 FITTING PROCEDURE : NULL
REMARK   3
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 3.900
REMARK   3   NUMBER OF PARTICLES               : 527205
REMARK   3   CTF CORRECTION METHOD             : NONE
REMARK   3
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL
REMARK   3
REMARK   3 OTHER DETAILS: NULL
REMARK   4
REMARK   4 8ERL COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 13-OCT-22.
REMARK 100 THE DEPOSITION ID IS D_1000269269.
REMARK 245
REMARK 245 EXPERIMENTAL DETAILS
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE
REMARK 245   SPECIMEN TYPE                  : NULL
REMARK 245
REMARK 245 ELECTRON MICROSCOPE SAMPLE
REMARK 245   SAMPLE TYPE                    : PARTICLE
REMARK 245   PARTICLE TYPE                  : POINT
REMARK 245   NAME OF SAMPLE                 : LIPOPROTEIN LIPASE DIMER
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : 0.55
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL
REMARK 245   SAMPLE BUFFER                  : NULL
REMARK 245   PH                             : 8.00
REMARK 245   SAMPLE DETAILS                 : NULL
REMARK 245
REMARK 245 DATA ACQUISITION
REMARK 245   DATE OF EXPERIMENT                : NULL
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL
REMARK 245   TEMPERATURE (KELVIN)              : NULL
REMARK 245   MICROSCOPE MODEL                  : FEI TALOS ARCTICA
REMARK 245   DETECTOR TYPE                     : GATAN K3 (6K X 4K)
REMARK 245   MINIMUM DEFOCUS (NM)              : 1000.00
REMARK 245   MAXIMUM DEFOCUS (NM)              : 3000.00
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL
REMARK 245   NOMINAL CS                        : NULL
REMARK 245   IMAGING MODE                      : BRIGHT FIELD
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 5510.00
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM
REMARK 245   NOMINAL MAGNIFICATION             : NULL
REMARK 245   CALIBRATED MAGNIFICATION          : NULL
REMARK 245   SOURCE                            : FIELD EMISSION GUN
REMARK 245   ACCELERATION VOLTAGE (KV)         : 200
REMARK 245   IMAGING DETAILS                   : NULL
REMARK 247
REMARK 247 ELECTRON MICROSCOPY
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION
REMARK 247  OF THE STRUCTURE FACTORS.
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A     1
REMARK 465     GLU A     2
REMARK 465     SER A     3
REMARK 465     LYS A     4
REMARK 465     ALA A     5
REMARK 465     LEU A     6
REMARK 465     LEU A     7
REMARK 465     LEU A     8
REMARK 465     LEU A     9
REMARK 465     ALA A    10
REMARK 465     LEU A    11
REMARK 465     SER A    12
REMARK 465     VAL A    13
REMARK 465     CYS A    14
REMARK 465     LEU A    15
REMARK 465     GLN A    16
REMARK 465     SER A    17
REMARK 465     LEU A    18
REMARK 465     THR A    19
REMARK 465     VAL A    20
REMARK 465     SER A    21
REMARK 465     ARG A    22
REMARK 465     GLY A    23
REMARK 465     GLY A    24
REMARK 465     LEU A    25
REMARK 465     VAL A    26
REMARK 465     ALA A    27
REMARK 465     ALA A    28
REMARK 465     ASP A    29
REMARK 465     ARG A    30
REMARK 465     ILE A    31
REMARK 465     THR A    32
REMARK 465     GLY A    33
REMARK 465     GLY A    34
REMARK 465     LYS A    35
REMARK 465     ASN A   247
REMARK 465     ILE A   248
REMARK 465     GLY A   249
REMARK 465     GLU A   250
REMARK 465     ALA A   251
REMARK 465     LEU A   252
REMARK 465     ARG A   253
REMARK 465     VAL A   254
REMARK 465     ILE A   255
REMARK 465     ALA A   256
REMARK 465     GLU A   257
REMARK 465     ARG A   258
REMARK 465     GLY A   259
REMARK 465     LEU A   260
REMARK 465     GLY A   261
REMARK 465     ASP A   262
REMARK 465     VAL A   263
REMARK 465     ASP A   264
REMARK 465     GLN A   265
REMARK 465     LEU A   266
REMARK 465     LYS A   471
REMARK 465     SER A   472
REMARK 465     LEU A   473
REMARK 465     ASN A   474
REMARK 465     ARG A   475
REMARK 465     LYS A   476
REMARK 465     SER A   477
REMARK 465     GLY A   478
REMARK 465     MET B     1
REMARK 465     GLU B     2
REMARK 465     SER B     3
REMARK 465     LYS B     4
REMARK 465     ALA B     5
REMARK 465     LEU B     6
REMARK 465     LEU B     7
REMARK 465     LEU B     8
REMARK 465     LEU B     9
REMARK 465     ALA B    10
REMARK 465     LEU B    11
REMARK 465     SER B    12
REMARK 465     VAL B    13
REMARK 465     CYS B    14
REMARK 465     LEU B    15
REMARK 465     GLN B    16
REMARK 465     SER B    17
REMARK 465     LEU B    18
REMARK 465     THR B    19
REMARK 465     VAL B    20
REMARK 465     SER B    21
REMARK 465     ARG B    22
REMARK 465     GLY B    23
REMARK 465     GLY B    24
REMARK 465     LEU B    25
REMARK 465     VAL B    26
REMARK 465     ALA B    27
REMARK 465     ALA B    28
REMARK 465     ASP B    29
REMARK 465     ARG B    30
REMARK 465     ILE B    31
REMARK 465     THR B    32
REMARK 465     GLY B    33
REMARK 465     GLY B    34
REMARK 465     LYS B    35
REMARK 465     ASN B   247
REMARK 465     ILE B   248
REMARK 465     GLY B   249
REMARK 465     GLU B   250
REMARK 465     ALA B   251
REMARK 465     LEU B   252
REMARK 465     ARG B   253
REMARK 465     VAL B   254
REMARK 465     ILE B   255
REMARK 465     ALA B   256
REMARK 465     GLU B   257
REMARK 465     ARG B   258
REMARK 465     GLY B   259
REMARK 465     LEU B   260
REMARK 465     GLY B   261
REMARK 465     ASP B   262
REMARK 465     VAL B   263
REMARK 465     ASP B   264
REMARK 465     GLN B   265
REMARK 465     LEU B   266
REMARK 465     LYS B   471
REMARK 465     SER B   472
REMARK 465     LEU B   473
REMARK 465     ASN B   474
REMARK 465     ARG B   475
REMARK 465     LYS B   476
REMARK 465     SER B   477
REMARK 465     GLY B   478
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    LEU A 102   CA  -  CB  -  CG  ANGL. DEV. =  19.5 DEGREES
REMARK 500    LEU A 277   CA  -  CB  -  CG  ANGL. DEV. =  18.6 DEGREES
REMARK 500    ILE A 320   CG1 -  CB  -  CG2 ANGL. DEV. = -16.4 DEGREES
REMARK 500    LEU B 102   CA  -  CB  -  CG  ANGL. DEV. =  19.5 DEGREES
REMARK 500    LEU B 277   CA  -  CB  -  CG  ANGL. DEV. =  18.6 DEGREES
REMARK 500    ILE B 320   CG1 -  CB  -  CG2 ANGL. DEV. = -16.4 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    GLU A  50       53.03    -91.82
REMARK 500    THR A  52      -65.09    -95.71
REMARK 500    ALA A  53       43.89   -141.36
REMARK 500    THR A  64     -167.80   -126.35
REMARK 500    ARG A 119       45.17   -141.05
REMARK 500    SER A 162     -125.61     58.69
REMARK 500    LEU A 185     -157.79    -90.85
REMARK 500    GLN A 227       56.85    -98.42
REMARK 500    SER A 270      -82.61   -147.15
REMARK 500    LYS A 310     -168.71   -100.77
REMARK 500    SER A 357       61.40     60.43
REMARK 500    THR A 361      -52.21   -120.60
REMARK 500    ASN A 422      -11.67     76.13
REMARK 500    TRP A 423       37.20   -154.47
REMARK 500    THR A 441     -129.42     56.50
REMARK 500    LYS A 444       76.68   -101.68
REMARK 500    LYS A 460       53.10     37.69
REMARK 500    GLU B  50       53.11    -91.90
REMARK 500    THR B  52      -65.05    -95.77
REMARK 500    ALA B  53       43.84   -141.40
REMARK 500    THR B  64     -167.77   -126.35
REMARK 500    ARG B 119       45.17   -141.04
REMARK 500    SER B 162     -125.57     58.67
REMARK 500    LEU B 185     -157.81    -90.88
REMARK 500    GLN B 227       56.90    -98.38
REMARK 500    LYS B 310     -168.76   -100.82
REMARK 500    SER B 357       61.39     60.51
REMARK 500    THR B 361      -52.24   -120.62
REMARK 500    ASN B 422      -11.72     76.08
REMARK 500    TRP B 423       37.16   -154.44
REMARK 500    THR B 441     -129.40     56.43
REMARK 500    LYS B 444       76.61   -101.61
REMARK 500    LYS B 460       53.17     37.67
REMARK 500
REMARK 500 REMARK: NULL
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: EMD-28554   RELATED DB: EMDB
REMARK 900 CRYOEM STRUCTURE OF LIPOPROTEIN LIPASE DIMER
DBREF  8ERL A    1   478  UNP    P11151   LIPL_BOVIN       1    478
DBREF  8ERL B    1   478  UNP    P11151   LIPL_BOVIN       1    478
SEQRES   1 A  478  MET GLU SER LYS ALA LEU LEU LEU LEU ALA LEU SER VAL
SEQRES   2 A  478  CYS LEU GLN SER LEU THR VAL SER ARG GLY GLY LEU VAL
SEQRES   3 A  478  ALA ALA ASP ARG ILE THR GLY GLY LYS ASP PHE ARG ASP
SEQRES   4 A  478  ILE GLU SER LYS PHE ALA LEU ARG THR PRO GLU ASP THR
SEQRES   5 A  478  ALA GLU ASP THR CYS HIS LEU ILE PRO GLY VAL THR GLU
SEQRES   6 A  478  SER VAL ALA ASN CYS HIS PHE ASN HIS SER SER LYS THR
SEQRES   7 A  478  PHE VAL VAL ILE HIS GLY TRP THR VAL THR GLY MET TYR
SEQRES   8 A  478  GLU SER TRP VAL PRO LYS LEU VAL ALA ALA LEU TYR LYS
SEQRES   9 A  478  ARG GLU PRO ASP SER ASN VAL ILE VAL VAL ASP TRP LEU
SEQRES  10 A  478  SER ARG ALA GLN GLN HIS TYR PRO VAL SER ALA GLY TYR
SEQRES  11 A  478  THR LYS LEU VAL GLY GLN ASP VAL ALA LYS PHE MET ASN
SEQRES  12 A  478  TRP MET ALA ASP GLU PHE ASN TYR PRO LEU GLY ASN VAL
SEQRES  13 A  478  HIS LEU LEU GLY TYR SER LEU GLY ALA HIS ALA ALA GLY
SEQRES  14 A  478  ILE ALA GLY SER LEU THR ASN LYS LYS VAL ASN ARG ILE
SEQRES  15 A  478  THR GLY LEU ASP PRO ALA GLY PRO ASN PHE GLU TYR ALA
SEQRES  16 A  478  GLU ALA PRO SER ARG LEU SER PRO ASP ASP ALA ASP PHE
SEQRES  17 A  478  VAL ASP VAL LEU HIS THR PHE THR ARG GLY SER PRO GLY
SEQRES  18 A  478  ARG SER ILE GLY ILE GLN LYS PRO VAL GLY HIS VAL ASP
SEQRES  19 A  478  ILE TYR PRO ASN GLY GLY THR PHE GLN PRO GLY CYS ASN
SEQRES  20 A  478  ILE GLY GLU ALA LEU ARG VAL ILE ALA GLU ARG GLY LEU
SEQRES  21 A  478  GLY ASP VAL ASP GLN LEU VAL LYS CYS SER HIS GLU ARG
SEQRES  22 A  478  SER VAL HIS LEU PHE ILE ASP SER LEU LEU ASN GLU GLU
SEQRES  23 A  478  ASN PRO SER LYS ALA TYR ARG CYS ASN SER LYS GLU ALA
SEQRES  24 A  478  PHE GLU LYS GLY LEU CYS LEU SER CYS ARG LYS ASN ARG
SEQRES  25 A  478  CYS ASN ASN MET GLY TYR GLU ILE ASN LYS VAL ARG ALA
SEQRES  26 A  478  LYS ARG SER SER LYS MET TYR LEU LYS THR ARG SER GLN
SEQRES  27 A  478  MET PRO TYR LYS VAL PHE HIS TYR GLN VAL LYS ILE HIS
SEQRES  28 A  478  PHE SER GLY THR GLU SER ASN THR TYR THR ASN GLN ALA
SEQRES  29 A  478  PHE GLU ILE SER LEU TYR GLY THR VAL ALA GLU SER GLU
SEQRES  30 A  478  ASN ILE PRO PHE THR LEU PRO GLU VAL SER THR ASN LYS
SEQRES  31 A  478  THR TYR SER PHE LEU LEU TYR THR GLU VAL ASP ILE GLY
SEQRES  32 A  478  GLU LEU LEU MET LEU LYS LEU LYS TRP ILE SER ASP SER
SEQRES  33 A  478  TYR PHE SER TRP SER ASN TRP TRP SER SER PRO GLY PHE
SEQRES  34 A  478  ASP ILE GLY LYS ILE ARG VAL LYS ALA GLY GLU THR GLN
SEQRES  35 A  478  LYS LYS VAL ILE PHE CYS SER ARG GLU LYS MET SER TYR
SEQRES  36 A  478  LEU GLN LYS GLY LYS SER PRO VAL ILE PHE VAL LYS CYS
SEQRES  37 A  478  HIS ASP LYS SER LEU ASN ARG LYS SER GLY
SEQRES   1 B  478  MET GLU SER LYS ALA LEU LEU LEU LEU ALA LEU SER VAL
SEQRES   2 B  478  CYS LEU GLN SER LEU THR VAL SER ARG GLY GLY LEU VAL
SEQRES   3 B  478  ALA ALA ASP ARG ILE THR GLY GLY LYS ASP PHE ARG ASP
SEQRES   4 B  478  ILE GLU SER LYS PHE ALA LEU ARG THR PRO GLU ASP THR
SEQRES   5 B  478  ALA GLU ASP THR CYS HIS LEU ILE PRO GLY VAL THR GLU
SEQRES   6 B  478  SER VAL ALA ASN CYS HIS PHE ASN HIS SER SER LYS THR
SEQRES   7 B  478  PHE VAL VAL ILE HIS GLY TRP THR VAL THR GLY MET TYR
SEQRES   8 B  478  GLU SER TRP VAL PRO LYS LEU VAL ALA ALA LEU TYR LYS
SEQRES   9 B  478  ARG GLU PRO ASP SER ASN VAL ILE VAL VAL ASP TRP LEU
SEQRES  10 B  478  SER ARG ALA GLN GLN HIS TYR PRO VAL SER ALA GLY TYR
SEQRES  11 B  478  THR LYS LEU VAL GLY GLN ASP VAL ALA LYS PHE MET ASN
SEQRES  12 B  478  TRP MET ALA ASP GLU PHE ASN TYR PRO LEU GLY ASN VAL
SEQRES  13 B  478  HIS LEU LEU GLY TYR SER LEU GLY ALA HIS ALA ALA GLY
SEQRES  14 B  478  ILE ALA GLY SER LEU THR ASN LYS LYS VAL ASN ARG ILE
SEQRES  15 B  478  THR GLY LEU ASP PRO ALA GLY PRO ASN PHE GLU TYR ALA
SEQRES  16 B  478  GLU ALA PRO SER ARG LEU SER PRO ASP ASP ALA ASP PHE
SEQRES  17 B  478  VAL ASP VAL LEU HIS THR PHE THR ARG GLY SER PRO GLY
SEQRES  18 B  478  ARG SER ILE GLY ILE GLN LYS PRO VAL GLY HIS VAL ASP
SEQRES  19 B  478  ILE TYR PRO ASN GLY GLY THR PHE GLN PRO GLY CYS ASN
SEQRES  20 B  478  ILE GLY GLU ALA LEU ARG VAL ILE ALA GLU ARG GLY LEU
SEQRES  21 B  478  GLY ASP VAL ASP GLN LEU VAL LYS CYS SER HIS GLU ARG
SEQRES  22 B  478  SER VAL HIS LEU PHE ILE ASP SER LEU LEU ASN GLU GLU
SEQRES  23 B  478  ASN PRO SER LYS ALA TYR ARG CYS ASN SER LYS GLU ALA
SEQRES  24 B  478  PHE GLU LYS GLY LEU CYS LEU SER CYS ARG LYS ASN ARG
SEQRES  25 B  478  CYS ASN ASN MET GLY TYR GLU ILE ASN LYS VAL ARG ALA
SEQRES  26 B  478  LYS ARG SER SER LYS MET TYR LEU LYS THR ARG SER GLN
SEQRES  27 B  478  MET PRO TYR LYS VAL PHE HIS TYR GLN VAL LYS ILE HIS
SEQRES  28 B  478  PHE SER GLY THR GLU SER ASN THR TYR THR ASN GLN ALA
SEQRES  29 B  478  PHE GLU ILE SER LEU TYR GLY THR VAL ALA GLU SER GLU
SEQRES  30 B  478  ASN ILE PRO PHE THR LEU PRO GLU VAL SER THR ASN LYS
SEQRES  31 B  478  THR TYR SER PHE LEU LEU TYR THR GLU VAL ASP ILE GLY
SEQRES  32 B  478  GLU LEU LEU MET LEU LYS LEU LYS TRP ILE SER ASP SER
SEQRES  33 B  478  TYR PHE SER TRP SER ASN TRP TRP SER SER PRO GLY PHE
SEQRES  34 B  478  ASP ILE GLY LYS ILE ARG VAL LYS ALA GLY GLU THR GLN
SEQRES  35 B  478  LYS LYS VAL ILE PHE CYS SER ARG GLU LYS MET SER TYR
SEQRES  36 B  478  LEU GLN LYS GLY LYS SER PRO VAL ILE PHE VAL LYS CYS
SEQRES  37 B  478  HIS ASP LYS SER LEU ASN ARG LYS SER GLY
HELIX    1 AA1 TRP A   94  GLU A  106  1                                  13
HELIX    2 AA2 TRP A  116  ALA A  120  5                                   5
HELIX    3 AA3 HIS A  123  PHE A  149  1                                  27
HELIX    4 AA4 LEU A  163  THR A  175  1                                  13
HELIX    5 AA5 GLU A  196  ARG A  200  5                                   5
HELIX    6 AA6 SER A  202  ALA A  206  5                                   5
HELIX    7 AA7 GLY A  239  THR A  241  5                                   3
HELIX    8 AA8 SER A  270  ASN A  284  1                                  15
HELIX    9 AA9 SER A  296  GLY A  303  1                                   8
HELIX   10 AB1 GLU A  451  TYR A  455  5                                   5
HELIX   11 AB2 TRP B   94  GLU B  106  1                                  13
HELIX   12 AB3 TRP B  116  ALA B  120  5                                   5
HELIX   13 AB4 HIS B  123  PHE B  149  1                                  27
HELIX   14 AB5 LEU B  163  THR B  175  1                                  13
HELIX   15 AB6 GLU B  196  ARG B  200  5                                   5
HELIX   16 AB7 SER B  202  ALA B  206  5                                   5
HELIX   17 AB8 GLY B  239  THR B  241  5                                   3
HELIX   18 AB9 HIS B  271  ASN B  284  1                                  14
HELIX   19 AC1 SER B  296  GLY B  303  1                                   8
HELIX   20 AC2 GLU B  451  TYR B  455  5                                   5
SHEET    1 AA110 PHE A  44  ARG A  47  0
SHEET    2 AA110 SER A 109  VAL A 114 -1  O  VAL A 113   N  ALA A  45
SHEET    3 AA110 LYS A  77  ILE A  82  1  N  LYS A  77   O  ASN A 110
SHEET    4 AA110 VAL A 156  SER A 162  1  O  HIS A 157   N  VAL A  80
SHEET    5 AA110 ILE A 182  PRO A 187  1  O  LEU A 185   N  GLY A 160
SHEET    6 AA110 VAL A 209  LEU A 212  1  O  ASP A 210   N  GLY A 184
SHEET    7 AA110 VAL A 233  PRO A 237  1  O  VAL A 233   N  VAL A 209
SHEET    8 AA110 SER A 329  LEU A 333  1  O  MET A 331   N  ASP A 234
SHEET    9 AA110 ALA A 291  CYS A 294 -1  N  CYS A 294   O  LYS A 330
SHEET   10 AA110 CYS A 313  ASN A 314 -1  O  ASN A 314   N  ALA A 291
SHEET    1 AA2 5 LEU A 395  THR A 398  0
SHEET    2 AA2 5 PHE A 344  LYS A 349 -1  N  PHE A 344   O  THR A 398
SHEET    3 AA2 5 ARG A 435  ALA A 438 -1  O  ARG A 435   N  LYS A 349
SHEET    4 AA2 5 VAL A 445  CYS A 448 -1  O  VAL A 445   N  VAL A 436
SHEET    5 AA2 5 VAL A 466  LYS A 467 -1  O  VAL A 466   N  CYS A 448
SHEET    1 AA3 4 GLU A 375  PHE A 381  0
SHEET    2 AA3 4 PHE A 365  GLY A 371 -1  N  PHE A 365   O  PHE A 381
SHEET    3 AA3 4 LEU A 405  LYS A 411 -1  O  LYS A 409   N  SER A 368
SHEET    4 AA3 4 PRO A 462  ILE A 464 -1  O  VAL A 463   N  LEU A 410
SHEET    1 AA410 PHE B  44  ARG B  47  0
SHEET    2 AA410 SER B 109  VAL B 114 -1  O  VAL B 113   N  ALA B  45
SHEET    3 AA410 LYS B  77  ILE B  82  1  N  LYS B  77   O  ASN B 110
SHEET    4 AA410 VAL B 156  SER B 162  1  O  HIS B 157   N  VAL B  80
SHEET    5 AA410 ILE B 182  PRO B 187  1  O  LEU B 185   N  GLY B 160
SHEET    6 AA410 VAL B 209  LEU B 212  1  O  ASP B 210   N  GLY B 184
SHEET    7 AA410 VAL B 233  PRO B 237  1  O  VAL B 233   N  VAL B 209
SHEET    8 AA410 SER B 329  LEU B 333  1  O  MET B 331   N  ASP B 234
SHEET    9 AA410 ALA B 291  CYS B 294 -1  N  CYS B 294   O  LYS B 330
SHEET   10 AA410 CYS B 313  ASN B 314 -1  O  ASN B 314   N  ALA B 291
SHEET    1 AA5 5 LEU B 395  THR B 398  0
SHEET    2 AA5 5 PHE B 344  LYS B 349 -1  N  PHE B 344   O  THR B 398
SHEET    3 AA5 5 ARG B 435  ALA B 438 -1  O  ARG B 435   N  LYS B 349
SHEET    4 AA5 5 VAL B 445  CYS B 448 -1  O  VAL B 445   N  VAL B 436
SHEET    5 AA5 5 VAL B 466  LYS B 467 -1  O  VAL B 466   N  CYS B 448
SHEET    1 AA6 4 GLU B 375  PHE B 381  0
SHEET    2 AA6 4 PHE B 365  GLY B 371 -1  N  PHE B 365   O  PHE B 381
SHEET    3 AA6 4 LEU B 405  LYS B 411 -1  O  LYS B 409   N  SER B 368
SHEET    4 AA6 4 PRO B 462  ILE B 464 -1  O  VAL B 463   N  LEU B 410
SSBOND   1 CYS A   57    CYS A   70                          1555   1555  2.03
SSBOND   2 CYS A  294    CYS A  305                          1555   1555  2.03
SSBOND   3 CYS A  308    CYS A  313                          1555   1555  2.03
SSBOND   4 CYS A  448    CYS A  468                          1555   1555  2.03
SSBOND   5 CYS B   57    CYS B   70                          1555   1555  2.03
SSBOND   6 CYS B  294    CYS B  305                          1555   1555  2.03
SSBOND   7 CYS B  308    CYS B  313                          1555   1555  2.03
SSBOND   8 CYS B  448    CYS B  468                          1555   1555  2.03
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      1.000000  0.000000  0.000000        0.00000
SCALE2      0.000000  1.000000  0.000000        0.00000
SCALE3      0.000000  0.000000  1.000000        0.00000
TER    3301      ASP A 470
TER    6602      ASP B 470
MASTER      303    0    0   20   38    0    0    6 6600    2   16   74
END