longtext: 8g0n-pdb

content
HEADER    HYDROLASE                               31-JAN-23   8G0N
TITLE     FPHI, STAPHYLOCOCCUS AUREUS FLUOROPHOSPHONATE-BINDING SERINE
TITLE    2 HYDROLASES I, APO FORM
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: FLUOROPHOSPHONATE-BINDING SERINE HYDROLASE I;
COMPND   3 CHAIN: A;
COMPND   4 FRAGMENT: N-TERMINAL GPG FROM EXPRESSION TAG;
COMPND   5 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: STAPHYLOCOCCUS AUREUS USA300-0114;
SOURCE   3 ORGANISM_TAXID: 1385527;
SOURCE   4 STRAIN: USA300;
SOURCE   5 GENE: EST_1;
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3);
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 469008;
SOURCE   8 EXPRESSION_SYSTEM_PLASMID: F1012
KEYWDS    FPHI, STAPHYLOCOCCUS AUREUS, S. AUREUS, FLUOROPHOSPHONATE-BINDING,
KEYWDS   2 SERINE HYDROLASES, LIPASE, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    M.FELLNER
REVDAT   1   14-FEB-24 8G0N    0
JRNL        AUTH   M.FELLNER
JRNL        TITL   FPHI, STAPHYLOCOCCUS AUREUS FLUOROPHOSPHONATE-BINDING SERINE
JRNL        TITL 2 HYDROLASES I, APO FORM
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   2
REMARK   2 RESOLUTION.    1.14 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX 1.20.1-4487
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : ML
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.14
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 47.54
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.340
REMARK   3   COMPLETENESS FOR RANGE        (%) : 98.8
REMARK   3   NUMBER OF REFLECTIONS             : 87099
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.132
REMARK   3   R VALUE            (WORKING SET) : 0.132
REMARK   3   FREE R VALUE                     : 0.145
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.940
REMARK   3   FREE R VALUE TEST SET COUNT      : 4304
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 47.5400 -  3.5400    0.97     2939   149  0.1512 0.1546
REMARK   3     2  3.5400 -  2.8100    1.00     2875   153  0.1366 0.1388
REMARK   3     3  2.8100 -  2.4500    1.00     2839   145  0.1380 0.1645
REMARK   3     4  2.4500 -  2.2300    1.00     2873   128  0.1238 0.1276
REMARK   3     5  2.2300 -  2.0700    1.00     2816   145  0.1179 0.1369
REMARK   3     6  2.0700 -  1.9500    1.00     2802   159  0.1178 0.1264
REMARK   3     7  1.9500 -  1.8500    1.00     2774   162  0.1180 0.1351
REMARK   3     8  1.8500 -  1.7700    1.00     2807   140  0.1161 0.1319
REMARK   3     9  1.7700 -  1.7000    1.00     2817   133  0.1165 0.1515
REMARK   3    10  1.7000 -  1.6400    1.00     2780   160  0.1107 0.1285
REMARK   3    11  1.6400 -  1.5900    1.00     2769   138  0.1054 0.1373
REMARK   3    12  1.5900 -  1.5500    1.00     2826   138  0.0982 0.1213
REMARK   3    13  1.5500 -  1.5000    1.00     2755   154  0.1002 0.1253
REMARK   3    14  1.5000 -  1.4700    1.00     2783   134  0.1065 0.1285
REMARK   3    15  1.4700 -  1.4300    1.00     2766   154  0.1127 0.1255
REMARK   3    16  1.4300 -  1.4000    1.00     2786   148  0.1177 0.1605
REMARK   3    17  1.4000 -  1.3800    1.00     2765   144  0.1380 0.1618
REMARK   3    18  1.3800 -  1.3500    1.00     2768   140  0.1347 0.1540
REMARK   3    19  1.3500 -  1.3300    1.00     2749   138  0.1299 0.1397
REMARK   3    20  1.3300 -  1.3000    1.00     2800   150  0.1241 0.1404
REMARK   3    21  1.3000 -  1.2800    1.00     2744   142  0.1174 0.1305
REMARK   3    22  1.2800 -  1.2600    1.00     2774   150  0.1202 0.1309
REMARK   3    23  1.2600 -  1.2400    1.00     2771   126  0.1250 0.1467
REMARK   3    24  1.2400 -  1.2300    1.00     2743   158  0.1369 0.1328
REMARK   3    25  1.2300 -  1.2100    1.00     2769   139  0.1463 0.1819
REMARK   3    26  1.2100 -  1.1900    1.00     2769   134  0.1652 0.1661
REMARK   3    27  1.1900 -  1.1800    1.00     2786   139  0.1841 0.2100
REMARK   3    28  1.1800 -  1.1700    0.99     2708   155  0.2295 0.2689
REMARK   3    29  1.1700 -  1.1500    0.90     2477   134  0.2813 0.3002
REMARK   3    30  1.1500 -  1.1400    0.79     2165   115  0.3489 0.3638
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL
REMARK   3   SOLVENT RADIUS     : 1.10
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.110
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 12.750
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :  0.007           NULL
REMARK   3   ANGLE     :  0.981           NULL
REMARK   3   CHIRALITY :  0.082            320
REMARK   3   PLANARITY :  0.008            406
REMARK   3   DIHEDRAL  :  5.362            309
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 8G0N COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 01-FEB-23.
REMARK 100 THE DEPOSITION ID IS D_1000271996.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 17-MAR-22
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 6.0
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : AUSTRALIAN SYNCHROTRON
REMARK 200  BEAMLINE                       : MX2
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9536
REMARK 200  MONOCHROMATOR                  : C(111)
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : PIXEL
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS EIGER X 16M
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS 20220220
REMARK 200  DATA SCALING SOFTWARE          : AIMLESS 0.7.8
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 87208
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.140
REMARK 200  RESOLUTION RANGE LOW       (A) : 47.540
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 98.9
REMARK 200  DATA REDUNDANCY                : 9.500
REMARK 200  R MERGE                    (I) : 0.04600
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 19.7000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.14
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.16
REMARK 200  COMPLETENESS FOR SHELL     (%) : NULL
REMARK 200  DATA REDUNDANCY IN SHELL       : 6.60
REMARK 200  R MERGE FOR SHELL          (I) : 0.83700
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER 2.8.3
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 42.94
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.16
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.2 UL 10.2 MG/ML FPHI (20MM TRIS PH
REMARK 280  8.0, 150MM NACL) WERE MIXED WITH 0.2 UL OF RESERVOIR SOLUTION.
REMARK 280  SITTING DROP RESERVOIR CONTAINED 200MM MAGNESIUM CHLORIDE
REMARK 280  HEXAHYDRATE, 100MM MES PH 6.0 AND 20% W/V PEG 6000. CRYSTAL
REMARK 280  APPEARED WITHIN A DAY AT 16C AND GREW UNTIL DAY 2.5. CRYSTAL WAS
REMARK 280  INCUBATED FOR ~10S IN A SOLUTION OF ~25% GLYCEROL, 75% RESERVOIR
REMARK 280  PRIOR TO FREEZING., VAPOR DIFFUSION, SITTING DROP, TEMPERATURE
REMARK 280  289.15K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X+1/2,-Y,Z+1/2
REMARK 290       3555   -X,Y+1/2,-Z+1/2
REMARK 290       4555   X+1/2,-Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       25.72850
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       38.19000
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       30.37100
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       38.19000
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       25.72850
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       30.37100
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     GLY A    -2
REMARK 465     PRO A    -1
REMARK 465     GLY A     0
REMARK 465     MET A     1
REMARK 465     ARG A     2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   O    HOH A   408     O    HOH A   531              1.93
REMARK 500   O    HOH A   447     O    HOH A   601              2.12
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS
REMARK 500
REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC
REMARK 500 SYMMETRY ARE IN CLOSE CONTACT.  AN ATOM LOCATED WITHIN 0.15
REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A
REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375
REMARK 500 INSTEAD OF REMARK 500.  ATOMS WITH NON-BLANK ALTERNATE
REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS.
REMARK 500
REMARK 500 DISTANCE CUTOFF:
REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS
REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI  SSYMOP   DISTANCE
REMARK 500   OE2  GLU A    71     O    HOH A   611     3545     1.95
REMARK 500   OE2  GLU A    74     O    HOH A   405     3545     2.05
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    SER A  94     -113.61     63.20
REMARK 500    SER A  94     -110.81     52.32
REMARK 500
REMARK 500 REMARK: NULL
REMARK 620
REMARK 620 METAL COORDINATION
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              MG A 302  MG
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 GLU A  38   OE1
REMARK 620 2 HOH A 405   O    95.8
REMARK 620 3 HOH A 432   O    86.8  84.5
REMARK 620 4 HOH A 479   O    84.3 176.9  92.5
REMARK 620 5 HOH A 563   O    94.1  93.8 178.1  89.2
REMARK 620 6 HOH A 611   O   170.5  92.9  90.3  86.7  89.0
REMARK 620 N                    1     2     3     4     5
REMARK 620
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL
REMARK 620                              MG A 301  MG
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 ASP A  68   OD1
REMARK 620 2 GLU A 196   OE2  45.4
REMARK 620 3 HOH A 417   O    44.2   2.9
REMARK 620 4 HOH A 516   O    44.4   3.6   6.1
REMARK 620 5 HOH A 549   O    41.2   4.3   4.1   4.5
REMARK 620 6 HOH A 605   O    42.7   2.8   3.7   3.1   1.7
REMARK 620 N                    1     2     3     4     5
DBREF  8G0N A    1   244  UNP    X5DUZ9   X5DUZ9_STAAU     1    244
SEQADV 8G0N GLY A   -2  UNP  X5DUZ9              EXPRESSION TAG
SEQADV 8G0N PRO A   -1  UNP  X5DUZ9              EXPRESSION TAG
SEQADV 8G0N GLY A    0  UNP  X5DUZ9              EXPRESSION TAG
SEQRES   1 A  247  GLY PRO GLY MET ARG ILE LYS THR PRO SER PRO SER TYR
SEQRES   2 A  247  LEU LYS GLY THR ASN GLY HIS ALA ILE LEU LEU LEU HIS
SEQRES   3 A  247  SER PHE THR GLY THR ASN ARG ASP VAL LYS HIS LEU ALA
SEQRES   4 A  247  ALA GLU LEU ASN ASP GLN GLY PHE SER CYS TYR ALA PRO
SEQRES   5 A  247  ASN TYR PRO GLY HIS GLY LEU LEU LEU LYS ASP PHE MET
SEQRES   6 A  247  THR TYR ASN VAL ASP ASP TRP TRP GLU GLU VAL GLU LYS
SEQRES   7 A  247  ALA TYR GLN PHE LEU VAL ASN GLU GLY TYR GLU SER ILE
SEQRES   8 A  247  SER ALA THR GLY VAL SER LEU GLY GLY LEU MET THR LEU
SEQRES   9 A  247  LYS LEU ALA GLN HIS TYR PRO LEU LYS ARG ILE ALA VAL
SEQRES  10 A  247  MET SER ALA PRO LYS GLU LYS SER ASP ASP GLY LEU ILE
SEQRES  11 A  247  GLU HIS LEU VAL TYR TYR SER GLN ARG MET SER ASN ILE
SEQRES  12 A  247  LEU ASN LEU ASP GLN GLN ALA SER SER ALA GLN LEU ALA
SEQRES  13 A  247  ALA ILE ASP ASP TYR GLU GLY GLU ILE THR LYS PHE GLN
SEQRES  14 A  247  HIS PHE ILE ASP ASP ILE MET THR ASN LEU ASN VAL ILE
SEQRES  15 A  247  LYS MET PRO ALA ASN ILE LEU PHE GLY GLY LYS ASP ALA
SEQRES  16 A  247  PRO SER TYR GLU THR SER ALA HIS PHE ILE TYR GLU HIS
SEQRES  17 A  247  LEU GLY SER VAL ASP LYS GLU LEU ASN GLY LEU LYS ASP
SEQRES  18 A  247  SER HIS HIS LEU MET THR HIS GLY GLU GLY ARG ASP ILE
SEQRES  19 A  247  LEU GLU GLU ASN VAL ILE ARG PHE PHE ASN ALA LEU THR
HET     MG  A 301       1
HET     MG  A 302       1
HET     CL  A 303       1
HETNAM      MG MAGNESIUM ION
HETNAM      CL CHLORIDE ION
FORMUL   2   MG    2(MG 2+)
FORMUL   4   CL    CL 1-
FORMUL   5  HOH   *228(H2 O)
HELIX    1 AA1 THR A   28  ASP A   31  5                                   4
HELIX    2 AA2 VAL A   32  GLN A   42  1                                  11
HELIX    3 AA3 LEU A   57  MET A   62  1                                   6
HELIX    4 AA4 ASN A   65  GLU A   83  1                                  19
HELIX    5 AA5 SER A   94  TYR A  107  1                                  14
HELIX    6 AA6 SER A  122  ASN A  142  1                                  21
HELIX    7 AA7 ASP A  144  ALA A  154  1                                  11
HELIX    8 AA8 ILE A  155  ASP A  157  5                                   3
HELIX    9 AA9 TYR A  158  ASN A  175  1                                  18
HELIX   10 AB1 LEU A  176  ILE A  179  5                                   4
HELIX   11 AB2 ALA A  192  LEU A  206  1                                  15
HELIX   12 AB3 GLY A  228  ALA A  242  1                                  15
SHEET    1 AA1 7 SER A   9  LEU A  11  0
SHEET    2 AA1 7 SER A  45  ALA A  48 -1  O  CYS A  46   N  LEU A  11
SHEET    3 AA1 7 HIS A  17  LEU A  22  1  N  HIS A  17   O  SER A  45
SHEET    4 AA1 7 SER A  87  VAL A  93  1  O  THR A  91   N  LEU A  20
SHEET    5 AA1 7 ILE A 112  MET A 115  1  O  MET A 115   N  GLY A  92
SHEET    6 AA1 7 ALA A 183  GLY A 188  1  O  LEU A 186   N  VAL A 114
SHEET    7 AA1 7 LYS A 211  LEU A 216  1  O  ASN A 214   N  ILE A 185
LINK         OE1 GLU A  38                MG    MG A 302     1555   1555  2.16
LINK         OD1 ASP A  68                MG    MG A 301     1555   2555  2.07
LINK         OE2 GLU A 196                MG    MG A 301     1555   1555  2.07
LINK        MG    MG A 301                 O   HOH A 417     1555   1555  2.06
LINK        MG    MG A 301                 O   HOH A 516     1555   1555  2.10
LINK        MG    MG A 301                 O   HOH A 549     1555   1555  2.09
LINK        MG    MG A 301                 O   HOH A 605     1555   1555  2.07
LINK        MG    MG A 302                 O   HOH A 405     1555   1555  2.02
LINK        MG    MG A 302                 O   HOH A 432     1555   1555  2.10
LINK        MG    MG A 302                 O   HOH A 479     1555   1555  1.99
LINK        MG    MG A 302                 O   HOH A 563     1555   1555  2.01
LINK        MG    MG A 302                 O   HOH A 611     1555   1555  2.11
CRYST1   51.457   60.742   76.380  90.00  90.00  90.00 P 21 21 21    4
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.019434  0.000000  0.000000        0.00000
SCALE2      0.000000  0.016463  0.000000        0.00000
SCALE3      0.000000  0.000000  0.013092        0.00000
TER    4192      THR A 244
MASTER      312    0    3   12    7    0    0    6 2146    1   15   19
END