longtext: 8h5o-pdb

content
HEADER    HYDROLASE                               13-OCT-22   8H5O
TITLE     CRYSTAL STRUCTURE OF PETASE S121E/P181V/D186H/N233C/S242T/N246D/S282C
TITLE    2 MUTANT FROM IDEONELLA SAKAIENSIS
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: POLY(ETHYLENE TEREPHTHALATE) HYDROLASE;
COMPND   3 CHAIN: A;
COMPND   4 SYNONYM: PET HYDROLASE,PETASE,PET-DIGESTING ENZYME;
COMPND   5 EC: 3.1.1.101;
COMPND   6 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: IDEONELLA SAKAIENSIS;
SOURCE   3 ORGANISM_TAXID: 1547922;
SOURCE   4 GENE: ISF6_4831;
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 562
KEYWDS    PET HYDROLASE ; IDEONELLA SAKAIENSIS; MUTANT, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    S.H.LEE,H.SEO,K.-J.KIM
REVDAT   1   25-OCT-23 8H5O    0
JRNL        AUTH   S.H.LEE,H.SEO,K.J.KIM
JRNL        TITL   A CASE OF BALANCE ENGINEERING EXHIBITS KINETIC RELATIONSHIP
JRNL        TITL 2 BETWEEN MESOPHILIC AND THERMOPHILIC POLY(ETHYLENE
JRNL        TITL 3 TEREPHTHALATE) DEPOLYMERASES.
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   2
REMARK   2 RESOLUTION.    2.10 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.8.0352
REMARK   3   AUTHORS     : MURSHUDOV,SKUBAK,LEBEDEV,PANNU,STEINER,
REMARK   3               : NICHOLLS,WINN,LONG,VAGIN
REMARK   3
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.10
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 29.01
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0.000
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.3
REMARK   3   NUMBER OF REFLECTIONS             : 14656
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.143
REMARK   3   R VALUE            (WORKING SET) : 0.141
REMARK   3   FREE R VALUE                     : 0.186
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.900
REMARK   3   FREE R VALUE TEST SET COUNT      : 756
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : NULL
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 2.10
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 2.15
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 979
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 92.77
REMARK   3   BIN R VALUE           (WORKING SET) : 0.1330
REMARK   3   BIN FREE R VALUE SET COUNT          : 60
REMARK   3   BIN FREE R VALUE                    : 0.2230
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 1926
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 0
REMARK   3   SOLVENT ATOMS            : 148
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 21.39
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : -0.83000
REMARK   3    B22 (A**2) : 2.17000
REMARK   3    B33 (A**2) : -1.34000
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : 0.00000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): 0.174
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.151
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.090
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 3.299
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.966
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.950
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A):  1995 ; 0.008 ; 0.011
REMARK   3   BOND LENGTHS OTHERS               (A):  1730 ; 0.001 ; 0.016
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES):  2719 ; 1.544 ; 1.634
REMARK   3   BOND ANGLES OTHERS          (DEGREES):  4048 ; 0.510 ; 1.547
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):   267 ; 6.831 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):    13 ;17.305 ;10.000
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):   296 ;12.787 ;10.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):  NULL ;  NULL ;  NULL
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):   300 ; 0.071 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A):  2354 ; 0.008 ; 0.020
REMARK   3   GENERAL PLANES OTHERS             (A):   402 ; 0.001 ; 0.020
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN ANGLE OTHER ATOMS   (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN ANGLE OTHER ATOMS   (A**2):  NULL ;  NULL ;  NULL
REMARK   3   LONG RANGE B REFINED ATOMS     (A**2):  NULL ;  NULL ;  NULL
REMARK   3   LONG RANGE B OTHER ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : MASK
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.20
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE RIDING
REMARK   3  POSITIONS U VALUES : REFINED INDIVIDUALLY
REMARK   4
REMARK   4 8H5O COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 18-OCT-22.
REMARK 100 THE DEPOSITION ID IS D_1300032811.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 26-JUN-22
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : NULL
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : PAL/PLS
REMARK 200  BEAMLINE                       : 7A (6B, 6C1)
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.97934
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 270
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000
REMARK 200  DATA SCALING SOFTWARE          : HKL-2000
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 15455
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.100
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.8
REMARK 200  DATA REDUNDANCY                : 7.800
REMARK 200  R MERGE                    (I) : 0.12100
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 13.9000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.10
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.14
REMARK 200  COMPLETENESS FOR SHELL     (%) : 100.0
REMARK 200  DATA REDUNDANCY IN SHELL       : 8.10
REMARK 200  R MERGE FOR SHELL          (I) : 0.28400
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: MOLREP
REMARK 200 STARTING MODEL: 5XJH
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 38.99
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.02
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 20 % (W/V) PEG 3350, 0.2 M SODIUM
REMARK 280  FLUORIDE, VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 295K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X+1/2,-Y,Z+1/2
REMARK 290       3555   -X,Y+1/2,-Z+1/2
REMARK 290       4555   X+1/2,-Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       25.43150
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       47.57350
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       26.31000
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       47.57350
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       25.43150
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       26.31000
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A    13
REMARK 465     GLY A    14
REMARK 465     SER A    15
REMARK 465     SER A    16
REMARK 465     HIS A    17
REMARK 465     HIS A    18
REMARK 465     HIS A    19
REMARK 465     HIS A    20
REMARK 465     HIS A    21
REMARK 465     HIS A    22
REMARK 465     SER A    23
REMARK 465     SER A    24
REMARK 465     GLY A    25
REMARK 465     LEU A    26
REMARK 465     VAL A    27
REMARK 465     PRO A    28
REMARK 465     ARG A    29
REMARK 465     GLU A   292
REMARK 465     ASP A   293
REMARK 465     PRO A   294
REMARK 465     ALA A   295
REMARK 465     ALA A   296
REMARK 465     ASN A   297
REMARK 465     LYS A   298
REMARK 465     ALA A   299
REMARK 465     ARG A   300
REMARK 465     LYS A   301
REMARK 465     GLU A   302
REMARK 465     ALA A   303
REMARK 465     GLU A   304
REMARK 465     LEU A   305
REMARK 465     ALA A   306
REMARK 465     ALA A   307
REMARK 465     ALA A   308
REMARK 465     THR A   309
REMARK 465     ALA A   310
REMARK 465     GLU A   311
REMARK 465     GLN A   312
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   O    HOH A   511     O    HOH A   527              2.15
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    ARG A 132   NE  -  CZ  -  NH1 ANGL. DEV. =   4.5 DEGREES
REMARK 500    ARG A 132   NE  -  CZ  -  NH2 ANGL. DEV. =  -5.1 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    HIS A  32       48.00   -146.28
REMARK 500    ASN A  73       45.51   -141.66
REMARK 500    SER A 160     -120.68     61.72
REMARK 500    SER A 214      -86.57   -142.32
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: PLANAR GROUPS
REMARK 500
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS
REMARK 500 AN RMSD GREATER THAN THIS VALUE
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500  M RES CSSEQI        RMS     TYPE
REMARK 500    ARG A  53         0.09    SIDE CHAIN
REMARK 500    ARG A  59         0.12    SIDE CHAIN
REMARK 500    ARG A 123         0.12    SIDE CHAIN
REMARK 500    ARG A 224         0.20    SIDE CHAIN
REMARK 500    ARG A 280         0.07    SIDE CHAIN
REMARK 500
REMARK 500 REMARK: NULL
DBREF1 8H5O A   34   290  UNP                  PETH_IDESA
DBREF2 8H5O A     A0A0K8P6T7                         34         290
SEQADV 8H5O MET A   13  UNP  A0A0K8P6T           INITIATING METHIONINE
SEQADV 8H5O GLY A   14  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O SER A   15  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O SER A   16  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O HIS A   17  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O HIS A   18  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O HIS A   19  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O HIS A   20  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O HIS A   21  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O HIS A   22  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O SER A   23  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O SER A   24  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O GLY A   25  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O LEU A   26  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O VAL A   27  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O PRO A   28  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O ARG A   29  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O GLY A   30  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O SER A   31  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O HIS A   32  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O MET A   33  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O GLU A  121  UNP  A0A0K8P6T SER   121 ENGINEERED MUTATION
SEQADV 8H5O VAL A  181  UNP  A0A0K8P6T PRO   181 ENGINEERED MUTATION
SEQADV 8H5O HIS A  186  UNP  A0A0K8P6T ASP   186 ENGINEERED MUTATION
SEQADV 8H5O CYS A  233  UNP  A0A0K8P6T ASN   233 ENGINEERED MUTATION
SEQADV 8H5O THR A  242  UNP  A0A0K8P6T SER   242 ENGINEERED MUTATION
SEQADV 8H5O ASP A  246  UNP  A0A0K8P6T ASN   246 ENGINEERED MUTATION
SEQADV 8H5O CYS A  282  UNP  A0A0K8P6T SER   282 ENGINEERED MUTATION
SEQADV 8H5O LEU A  291  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O GLU A  292  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O ASP A  293  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O PRO A  294  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O ALA A  295  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O ALA A  296  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O ASN A  297  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O LYS A  298  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O ALA A  299  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O ARG A  300  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O LYS A  301  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O GLU A  302  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O ALA A  303  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O GLU A  304  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O LEU A  305  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O ALA A  306  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O ALA A  307  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O ALA A  308  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O THR A  309  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O ALA A  310  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O GLU A  311  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8H5O GLN A  312  UNP  A0A0K8P6T           EXPRESSION TAG
SEQRES   1 A  300  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES   2 A  300  LEU VAL PRO ARG GLY SER HIS MET ARG GLY PRO ASN PRO
SEQRES   3 A  300  THR ALA ALA SER LEU GLU ALA SER ALA GLY PRO PHE THR
SEQRES   4 A  300  VAL ARG SER PHE THR VAL SER ARG PRO SER GLY TYR GLY
SEQRES   5 A  300  ALA GLY THR VAL TYR TYR PRO THR ASN ALA GLY GLY THR
SEQRES   6 A  300  VAL GLY ALA ILE ALA ILE VAL PRO GLY TYR THR ALA ARG
SEQRES   7 A  300  GLN SER SER ILE LYS TRP TRP GLY PRO ARG LEU ALA SER
SEQRES   8 A  300  HIS GLY PHE VAL VAL ILE THR ILE ASP THR ASN SER THR
SEQRES   9 A  300  LEU ASP GLN PRO GLU SER ARG SER SER GLN GLN MET ALA
SEQRES  10 A  300  ALA LEU ARG GLN VAL ALA SER LEU ASN GLY THR SER SER
SEQRES  11 A  300  SER PRO ILE TYR GLY LYS VAL ASP THR ALA ARG MET GLY
SEQRES  12 A  300  VAL MET GLY TRP SER MET GLY GLY GLY GLY SER LEU ILE
SEQRES  13 A  300  SER ALA ALA ASN ASN PRO SER LEU LYS ALA ALA ALA VAL
SEQRES  14 A  300  GLN ALA PRO TRP HIS SER SER THR ASN PHE SER SER VAL
SEQRES  15 A  300  THR VAL PRO THR LEU ILE PHE ALA CYS GLU ASN ASP SER
SEQRES  16 A  300  ILE ALA PRO VAL ASN SER SER ALA LEU PRO ILE TYR ASP
SEQRES  17 A  300  SER MET SER ARG ASN ALA LYS GLN PHE LEU GLU ILE CYS
SEQRES  18 A  300  GLY GLY SER HIS SER CYS ALA ASN THR GLY ASN SER ASP
SEQRES  19 A  300  GLN ALA LEU ILE GLY LYS LYS GLY VAL ALA TRP MET LYS
SEQRES  20 A  300  ARG PHE MET ASP ASN ASP THR ARG TYR SER THR PHE ALA
SEQRES  21 A  300  CYS GLU ASN PRO ASN SER THR ARG VAL CYS ASP PHE ARG
SEQRES  22 A  300  THR ALA ASN CYS SER LEU GLU ASP PRO ALA ALA ASN LYS
SEQRES  23 A  300  ALA ARG LYS GLU ALA GLU LEU ALA ALA ALA THR ALA GLU
SEQRES  24 A  300  GLN
FORMUL   2  HOH   *148(H2 O)
HELIX    1 AA1 THR A   39  ALA A   45  1                                   7
HELIX    2 AA2 ARG A   90  LYS A   95  5                                   6
HELIX    3 AA3 TRP A   96  PHE A  106  1                                  11
HELIX    4 AA4 GLN A  119  GLY A  139  1                                  21
HELIX    5 AA5 SER A  160  ASN A  173  1                                  14
HELIX    6 AA6 PRO A  210  SER A  213  5                                   4
HELIX    7 AA7 SER A  214  MET A  222  1                                   9
HELIX    8 AA8 ASP A  246  ASP A  263  1                                  18
HELIX    9 AA9 ASP A  265  ARG A  267  5                                   3
HELIX   10 AB1 TYR A  268  GLU A  274  1                                   7
SHEET    1 AA1 9 VAL A  52  THR A  56  0
SHEET    2 AA1 9 ALA A  65  PRO A  71 -1  O  VAL A  68   N  PHE A  55
SHEET    3 AA1 9 VAL A 107  ASP A 112 -1  O  VAL A 108   N  TYR A  69
SHEET    4 AA1 9 VAL A  78  VAL A  84  1  N  ILE A  81   O  ILE A 109
SHEET    5 AA1 9 VAL A 149  TRP A 159  1  O  ASP A 150   N  VAL A  78
SHEET    6 AA1 9 ALA A 178  GLN A 182  1  O  GLN A 182   N  GLY A 158
SHEET    7 AA1 9 THR A 198  CYS A 203  1  O  PHE A 201   N  VAL A 181
SHEET    8 AA1 9 LYS A 227  ILE A 232  1  O  GLN A 228   N  ILE A 200
SHEET    9 AA1 9 VAL A 281  ALA A 287 -1  O  ARG A 285   N  PHE A 229
SSBOND   1 CYS A  203    CYS A  239                          1555   1555  2.25
SSBOND   2 CYS A  273    CYS A  289                          1555   1555  2.43
CRYST1   50.863   52.620   95.147  90.00  90.00  90.00 P 21 21 21    4
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.019661  0.000000  0.000000        0.00000
SCALE2      0.000000  0.019004  0.000000        0.00000
SCALE3      0.000000  0.000000  0.010510        0.00000
TER    1949      LEU A 291
MASTER      350    0    0   10    9    0    0    6 2074    1    4   24
END