longtext: 8j17-pdb

content
HEADER    HYDROLASE                               12-APR-23   8J17
TITLE     CRYSTAL STRUCTURE OF ISPETASE VARIANT
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: POLY(ETHYLENE TEREPHTHALATE) HYDROLASE;
COMPND   3 CHAIN: A, B, C;
COMPND   4 SYNONYM: ISPETASE, PET HYDROLASE,PETASE,PET-DIGESTING ENZYME;
COMPND   5 EC: 3.1.1.101;
COMPND   6 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: IDEONELLA SAKAIENSIS;
SOURCE   3 ORGANISM_TAXID: 1547922;
SOURCE   4 GENE: ISF6_4831;
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI 'BL21-GOLD(DE3)PLYSS AG';
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 866768
KEYWDS    POLYETHYLENE TEREPHTHALATE (PET), ISPETASE, PET DEGRADATION,
KEYWDS   2 HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    Q.D.YIN,Y.X.WANG
REVDAT   1   29-NOV-23 8J17    0
JRNL        AUTH   Q.YIN,J.ZHANG,S.MA,T.GU,M.WANG,S.YOU,S.YE,R.SU,Y.WANG,W.QI
JRNL        TITL   EFFICIENT POLYETHYLENE TEREPHTHALATE BIODEGRADATION BY AN
JRNL        TITL 2 ENGINEERED IDEONELLA SAKAIENSIS PETASE WITH A FIXED
JRNL        TITL 3 SUBSTRATE-BINDING W156 RESIDUE
JRNL        REF    GREEN CHEM                                 2013
JRNL        REFN                   ISSN 1463-9262
JRNL        DOI    10.1039/D3GC03663D
REMARK   2
REMARK   2 RESOLUTION.    1.97 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX 1.17.1_3660
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : GEOSTD + MONOMER LIBRARY + CDL V1.2
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.97
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 40.92
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.340
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.8
REMARK   3   NUMBER OF REFLECTIONS             : 71705
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.177
REMARK   3   R VALUE            (WORKING SET) : 0.176
REMARK   3   FREE R VALUE                     : 0.213
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.920
REMARK   3   FREE R VALUE TEST SET COUNT      : 3529
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 40.9200 -  5.7600    0.99     2934   142  0.1599 0.1882
REMARK   3     2  5.7500 -  4.5700    1.00     2810   149  0.1402 0.1555
REMARK   3     3  4.5700 -  3.9900    1.00     2771   145  0.1313 0.1688
REMARK   3     4  3.9900 -  3.6300    1.00     2759   152  0.1378 0.1762
REMARK   3     5  3.6300 -  3.3700    1.00     2751   156  0.1632 0.2210
REMARK   3     6  3.3700 -  3.1700    1.00     2719   154  0.1806 0.2000
REMARK   3     7  3.1700 -  3.0100    1.00     2758   139  0.1911 0.2256
REMARK   3     8  3.0100 -  2.8800    1.00     2725   122  0.1991 0.2710
REMARK   3     9  2.8800 -  2.7700    1.00     2708   138  0.2076 0.2638
REMARK   3    10  2.7700 -  2.6700    1.00     2734   145  0.1938 0.2483
REMARK   3    11  2.6700 -  2.5900    1.00     2731   133  0.1931 0.2115
REMARK   3    12  2.5900 -  2.5200    1.00     2697   135  0.1871 0.2553
REMARK   3    13  2.5200 -  2.4500    1.00     2742   132  0.1955 0.2305
REMARK   3    14  2.4500 -  2.3900    1.00     2682   120  0.1862 0.2489
REMARK   3    15  2.3900 -  2.3400    1.00     2770   128  0.1905 0.2517
REMARK   3    16  2.3400 -  2.2900    1.00     2654   152  0.1915 0.2392
REMARK   3    17  2.2900 -  2.2400    1.00     2747   131  0.2076 0.2539
REMARK   3    18  2.2400 -  2.2000    1.00     2681   135  0.2138 0.2613
REMARK   3    19  2.2000 -  2.1600    1.00     2719   146  0.2247 0.2834
REMARK   3    20  2.1600 -  2.1200    1.00     2680   138  0.2383 0.2790
REMARK   3    21  2.1200 -  2.0900    1.00     2675   156  0.2448 0.2941
REMARK   3    22  2.0900 -  2.0600    1.00     2687   150  0.2700 0.3444
REMARK   3    23  2.0600 -  2.0300    1.00     2653   140  0.2802 0.2795
REMARK   3    24  2.0300 -  2.0000    1.00     2713   141  0.3084 0.3409
REMARK   3    25  2.0000 -  1.9700    0.99     2676   150  0.3309 0.3543
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL
REMARK   3   SOLVENT RADIUS     : 1.11
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.216
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 24.907
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 37.30
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 43.91
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :  0.007           5908
REMARK   3   ANGLE     :  0.824           8054
REMARK   3   CHIRALITY :  0.054            888
REMARK   3   PLANARITY :  0.006           1066
REMARK   3   DIHEDRAL  : 16.461           2092
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 8J17 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 23-APR-23.
REMARK 100 THE DEPOSITION ID IS D_1300037008.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 12-OCT-22
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 6.5
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : SSRF
REMARK 200  BEAMLINE                       : BL10U2
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.97918
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : PIXEL
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS PILATUS 6M
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : NULL
REMARK 200  DATA SCALING SOFTWARE          : NULL
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 71765
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.970
REMARK 200  RESOLUTION RANGE LOW       (A) : 58.450
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.8
REMARK 200  DATA REDUNDANCY                : 11.40
REMARK 200  R MERGE                    (I) : NULL
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 14.7000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.97
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.02
REMARK 200  COMPLETENESS FOR SHELL     (%) : NULL
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL
REMARK 200  R MERGE FOR SHELL          (I) : NULL
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: NULL
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 57.81
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.92
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 100MM MES-NAOH, 1.7M MGSO4, PH 6.5,
REMARK 280  VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 290K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: C 2 2 21
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,-Y,Z+1/2
REMARK 290       3555   -X,Y,-Z+1/2
REMARK 290       4555   X,-Y,-Z
REMARK 290       5555   X+1/2,Y+1/2,Z
REMARK 290       6555   -X+1/2,-Y+1/2,Z+1/2
REMARK 290       7555   -X+1/2,Y+1/2,-Z+1/2
REMARK 290       8555   X+1/2,-Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       81.84500
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       81.84500
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   5  1.000000  0.000000  0.000000       26.28000
REMARK 290   SMTRY2   5  0.000000  1.000000  0.000000      116.90000
REMARK 290   SMTRY3   5  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   6 -1.000000  0.000000  0.000000       26.28000
REMARK 290   SMTRY2   6  0.000000 -1.000000  0.000000      116.90000
REMARK 290   SMTRY3   6  0.000000  0.000000  1.000000       81.84500
REMARK 290   SMTRY1   7 -1.000000  0.000000  0.000000       26.28000
REMARK 290   SMTRY2   7  0.000000  1.000000  0.000000      116.90000
REMARK 290   SMTRY3   7  0.000000  0.000000 -1.000000       81.84500
REMARK 290   SMTRY1   8  1.000000  0.000000  0.000000       26.28000
REMARK 290   SMTRY2   8  0.000000 -1.000000  0.000000      116.90000
REMARK 290   SMTRY3   8  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2, 3
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 3
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 375
REMARK 375 SPECIAL POSITION
REMARK 375 THE FOLLOWING ATOMS ARE FOUND TO BE WITHIN 0.15 ANGSTROMS
REMARK 375 OF A SYMMETRY RELATED ATOM AND ARE ASSUMED TO BE ON SPECIAL
REMARK 375 POSITIONS.
REMARK 375
REMARK 375 ATOM RES CSSEQI
REMARK 375      HOH B 474  LIES ON A SPECIAL POSITION.
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A    -2
REMARK 465     GLN A    -1
REMARK 465     LEU A   262
REMARK 465     GLU A   263
REMARK 465     HIS A   264
REMARK 465     HIS A   265
REMARK 465     HIS A   266
REMARK 465     HIS A   267
REMARK 465     HIS A   268
REMARK 465     HIS A   269
REMARK 465     MET B    -2
REMARK 465     GLN B    -1
REMARK 465     LEU B   262
REMARK 465     GLU B   263
REMARK 465     HIS B   264
REMARK 465     HIS B   265
REMARK 465     HIS B   266
REMARK 465     HIS B   267
REMARK 465     HIS B   268
REMARK 465     HIS B   269
REMARK 465     MET C    -2
REMARK 465     GLN C    -1
REMARK 465     LEU C   262
REMARK 465     GLU C   263
REMARK 465     HIS C   264
REMARK 465     HIS C   265
REMARK 465     HIS C   266
REMARK 465     HIS C   267
REMARK 465     HIS C   268
REMARK 465     HIS C   269
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    SER A 131     -119.69     65.47
REMARK 500    ALA A 180       75.00   -116.99
REMARK 500    SER A 185      -82.97   -126.28
REMARK 500    SER B 131     -117.36     61.69
REMARK 500    SER B 185      -82.86   -130.70
REMARK 500    SER C 131     -117.67     63.95
REMARK 500    SER C 185      -78.06   -124.96
REMARK 500
REMARK 500 REMARK: NULL
REMARK 525
REMARK 525 SOLVENT
REMARK 525
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 525 NUMBER; I=INSERTION CODE):
REMARK 525
REMARK 525  M RES CSSEQI
REMARK 525    HOH A 621        DISTANCE =  5.92 ANGSTROMS
REMARK 525    HOH A 622        DISTANCE =  6.37 ANGSTROMS
REMARK 525    HOH A 623        DISTANCE =  6.75 ANGSTROMS
DBREF1 8J17 A   -1   261  UNP                  PETH_IDESA
DBREF2 8J17 A     A0A0K8P6T7                         28         290
DBREF1 8J17 B   -1   261  UNP                  PETH_IDESA
DBREF2 8J17 B     A0A0K8P6T7                         28         290
DBREF1 8J17 C   -1   261  UNP                  PETH_IDESA
DBREF2 8J17 C     A0A0K8P6T7                         28         290
SEQADV 8J17 MET A   -2  UNP  A0A0K8P6T           INITIATING METHIONINE
SEQADV 8J17 PRO A   92  UNP  A0A0K8P6T SER   121 VARIANT
SEQADV 8J17 ALA A  157  UNP  A0A0K8P6T ASP   186 VARIANT
SEQADV 8J17 LEU A  262  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8J17 GLU A  263  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8J17 HIS A  264  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8J17 HIS A  265  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8J17 HIS A  266  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8J17 HIS A  267  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8J17 HIS A  268  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8J17 HIS A  269  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8J17 MET B   -2  UNP  A0A0K8P6T           INITIATING METHIONINE
SEQADV 8J17 PRO B   92  UNP  A0A0K8P6T SER   121 VARIANT
SEQADV 8J17 ALA B  157  UNP  A0A0K8P6T ASP   186 VARIANT
SEQADV 8J17 LEU B  262  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8J17 GLU B  263  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8J17 HIS B  264  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8J17 HIS B  265  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8J17 HIS B  266  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8J17 HIS B  267  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8J17 HIS B  268  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8J17 HIS B  269  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8J17 MET C   -2  UNP  A0A0K8P6T           INITIATING METHIONINE
SEQADV 8J17 PRO C   92  UNP  A0A0K8P6T SER   121 VARIANT
SEQADV 8J17 ALA C  157  UNP  A0A0K8P6T ASP   186 VARIANT
SEQADV 8J17 LEU C  262  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8J17 GLU C  263  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8J17 HIS C  264  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8J17 HIS C  265  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8J17 HIS C  266  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8J17 HIS C  267  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8J17 HIS C  268  UNP  A0A0K8P6T           EXPRESSION TAG
SEQADV 8J17 HIS C  269  UNP  A0A0K8P6T           EXPRESSION TAG
SEQRES   1 A  272  MET GLN THR ASN PRO TYR ALA ARG GLY PRO ASN PRO THR
SEQRES   2 A  272  ALA ALA SER LEU GLU ALA SER ALA GLY PRO PHE THR VAL
SEQRES   3 A  272  ARG SER PHE THR VAL SER ARG PRO SER GLY TYR GLY ALA
SEQRES   4 A  272  GLY THR VAL TYR TYR PRO THR ASN ALA GLY GLY THR VAL
SEQRES   5 A  272  GLY ALA ILE ALA ILE VAL PRO GLY TYR THR ALA ARG GLN
SEQRES   6 A  272  SER SER ILE LYS TRP TRP GLY PRO ARG LEU ALA SER HIS
SEQRES   7 A  272  GLY PHE VAL VAL ILE THR ILE ASP THR ASN SER THR LEU
SEQRES   8 A  272  ASP GLN PRO PRO SER ARG SER SER GLN GLN MET ALA ALA
SEQRES   9 A  272  LEU ARG GLN VAL ALA SER LEU ASN GLY THR SER SER SER
SEQRES  10 A  272  PRO ILE TYR GLY LYS VAL ASP THR ALA ARG MET GLY VAL
SEQRES  11 A  272  MET GLY TRP SER MET GLY GLY GLY GLY SER LEU ILE SER
SEQRES  12 A  272  ALA ALA ASN ASN PRO SER LEU LYS ALA ALA ALA PRO GLN
SEQRES  13 A  272  ALA PRO TRP ALA SER SER THR ASN PHE SER SER VAL THR
SEQRES  14 A  272  VAL PRO THR LEU ILE PHE ALA CYS GLU ASN ASP SER ILE
SEQRES  15 A  272  ALA PRO VAL ASN SER SER ALA LEU PRO ILE TYR ASP SER
SEQRES  16 A  272  MET SER ARG ASN ALA LYS GLN PHE LEU GLU ILE ASN GLY
SEQRES  17 A  272  GLY SER HIS SER CYS ALA ASN SER GLY ASN SER ASN GLN
SEQRES  18 A  272  ALA LEU ILE GLY LYS LYS GLY VAL ALA TRP MET LYS ARG
SEQRES  19 A  272  PHE MET ASP ASN ASP THR ARG TYR SER THR PHE ALA CYS
SEQRES  20 A  272  GLU ASN PRO ASN SER THR ARG VAL SER ASP PHE ARG THR
SEQRES  21 A  272  ALA ASN CYS SER LEU GLU HIS HIS HIS HIS HIS HIS
SEQRES   1 B  272  MET GLN THR ASN PRO TYR ALA ARG GLY PRO ASN PRO THR
SEQRES   2 B  272  ALA ALA SER LEU GLU ALA SER ALA GLY PRO PHE THR VAL
SEQRES   3 B  272  ARG SER PHE THR VAL SER ARG PRO SER GLY TYR GLY ALA
SEQRES   4 B  272  GLY THR VAL TYR TYR PRO THR ASN ALA GLY GLY THR VAL
SEQRES   5 B  272  GLY ALA ILE ALA ILE VAL PRO GLY TYR THR ALA ARG GLN
SEQRES   6 B  272  SER SER ILE LYS TRP TRP GLY PRO ARG LEU ALA SER HIS
SEQRES   7 B  272  GLY PHE VAL VAL ILE THR ILE ASP THR ASN SER THR LEU
SEQRES   8 B  272  ASP GLN PRO PRO SER ARG SER SER GLN GLN MET ALA ALA
SEQRES   9 B  272  LEU ARG GLN VAL ALA SER LEU ASN GLY THR SER SER SER
SEQRES  10 B  272  PRO ILE TYR GLY LYS VAL ASP THR ALA ARG MET GLY VAL
SEQRES  11 B  272  MET GLY TRP SER MET GLY GLY GLY GLY SER LEU ILE SER
SEQRES  12 B  272  ALA ALA ASN ASN PRO SER LEU LYS ALA ALA ALA PRO GLN
SEQRES  13 B  272  ALA PRO TRP ALA SER SER THR ASN PHE SER SER VAL THR
SEQRES  14 B  272  VAL PRO THR LEU ILE PHE ALA CYS GLU ASN ASP SER ILE
SEQRES  15 B  272  ALA PRO VAL ASN SER SER ALA LEU PRO ILE TYR ASP SER
SEQRES  16 B  272  MET SER ARG ASN ALA LYS GLN PHE LEU GLU ILE ASN GLY
SEQRES  17 B  272  GLY SER HIS SER CYS ALA ASN SER GLY ASN SER ASN GLN
SEQRES  18 B  272  ALA LEU ILE GLY LYS LYS GLY VAL ALA TRP MET LYS ARG
SEQRES  19 B  272  PHE MET ASP ASN ASP THR ARG TYR SER THR PHE ALA CYS
SEQRES  20 B  272  GLU ASN PRO ASN SER THR ARG VAL SER ASP PHE ARG THR
SEQRES  21 B  272  ALA ASN CYS SER LEU GLU HIS HIS HIS HIS HIS HIS
SEQRES   1 C  272  MET GLN THR ASN PRO TYR ALA ARG GLY PRO ASN PRO THR
SEQRES   2 C  272  ALA ALA SER LEU GLU ALA SER ALA GLY PRO PHE THR VAL
SEQRES   3 C  272  ARG SER PHE THR VAL SER ARG PRO SER GLY TYR GLY ALA
SEQRES   4 C  272  GLY THR VAL TYR TYR PRO THR ASN ALA GLY GLY THR VAL
SEQRES   5 C  272  GLY ALA ILE ALA ILE VAL PRO GLY TYR THR ALA ARG GLN
SEQRES   6 C  272  SER SER ILE LYS TRP TRP GLY PRO ARG LEU ALA SER HIS
SEQRES   7 C  272  GLY PHE VAL VAL ILE THR ILE ASP THR ASN SER THR LEU
SEQRES   8 C  272  ASP GLN PRO PRO SER ARG SER SER GLN GLN MET ALA ALA
SEQRES   9 C  272  LEU ARG GLN VAL ALA SER LEU ASN GLY THR SER SER SER
SEQRES  10 C  272  PRO ILE TYR GLY LYS VAL ASP THR ALA ARG MET GLY VAL
SEQRES  11 C  272  MET GLY TRP SER MET GLY GLY GLY GLY SER LEU ILE SER
SEQRES  12 C  272  ALA ALA ASN ASN PRO SER LEU LYS ALA ALA ALA PRO GLN
SEQRES  13 C  272  ALA PRO TRP ALA SER SER THR ASN PHE SER SER VAL THR
SEQRES  14 C  272  VAL PRO THR LEU ILE PHE ALA CYS GLU ASN ASP SER ILE
SEQRES  15 C  272  ALA PRO VAL ASN SER SER ALA LEU PRO ILE TYR ASP SER
SEQRES  16 C  272  MET SER ARG ASN ALA LYS GLN PHE LEU GLU ILE ASN GLY
SEQRES  17 C  272  GLY SER HIS SER CYS ALA ASN SER GLY ASN SER ASN GLN
SEQRES  18 C  272  ALA LEU ILE GLY LYS LYS GLY VAL ALA TRP MET LYS ARG
SEQRES  19 C  272  PHE MET ASP ASN ASP THR ARG TYR SER THR PHE ALA CYS
SEQRES  20 C  272  GLU ASN PRO ASN SER THR ARG VAL SER ASP PHE ARG THR
SEQRES  21 C  272  ALA ASN CYS SER LEU GLU HIS HIS HIS HIS HIS HIS
FORMUL   4  HOH   *761(H2 O)
HELIX    1 AA1 THR A   10  ALA A   16  1                                   7
HELIX    2 AA2 ARG A   61  LYS A   66  5                                   6
HELIX    3 AA3 TRP A   67  SER A   74  1                                   8
HELIX    4 AA4 GLN A   90  GLY A  110  1                                  21
HELIX    5 AA5 SER A  131  ASN A  144  1                                  14
HELIX    6 AA6 SER A  185  MET A  193  1                                   9
HELIX    7 AA7 ASN A  217  ASP A  234  1                                  18
HELIX    8 AA8 ASP A  236  ARG A  238  5                                   3
HELIX    9 AA9 TYR A  239  GLU A  245  1                                   7
HELIX   10 AB1 THR B   10  ALA B   16  1                                   7
HELIX   11 AB2 ARG B   61  LYS B   66  1                                   6
HELIX   12 AB3 TRP B   67  SER B   74  1                                   8
HELIX   13 AB4 GLN B   90  GLY B  110  1                                  21
HELIX   14 AB5 SER B  131  ASN B  144  1                                  14
HELIX   15 AB6 PRO B  181  SER B  184  5                                   4
HELIX   16 AB7 SER B  185  MET B  193  1                                   9
HELIX   17 AB8 ASN B  217  ASP B  234  1                                  18
HELIX   18 AB9 ASP B  236  ARG B  238  5                                   3
HELIX   19 AC1 TYR B  239  GLU B  245  1                                   7
HELIX   20 AC2 THR C   10  ALA C   16  1                                   7
HELIX   21 AC3 ARG C   61  LYS C   66  5                                   6
HELIX   22 AC4 TRP C   67  SER C   74  1                                   8
HELIX   23 AC5 GLN C   90  GLY C  110  1                                  21
HELIX   24 AC6 SER C  131  ASN C  144  1                                  14
HELIX   25 AC7 SER C  185  MET C  193  1                                   9
HELIX   26 AC8 ASN C  217  ASP C  234  1                                  18
HELIX   27 AC9 ASP C  236  ARG C  238  5                                   3
HELIX   28 AD1 TYR C  239  GLU C  245  1                                   7
SHEET    1 AA1 6 VAL A  23  THR A  27  0
SHEET    2 AA1 6 ALA A  36  PRO A  42 -1  O  VAL A  39   N  PHE A  26
SHEET    3 AA1 6 VAL A  78  ASP A  83 -1  O  VAL A  79   N  TYR A  40
SHEET    4 AA1 6 VAL A  49  VAL A  55  1  N  ILE A  52   O  ILE A  80
SHEET    5 AA1 6 VAL A 120  TRP A 130  1  O  ASP A 121   N  VAL A  49
SHEET    6 AA1 6 ALA A 149  GLN A 153  1  O  GLN A 153   N  GLY A 129
SHEET    1 AA2 3 THR A 169  CYS A 174  0
SHEET    2 AA2 3 LYS A 198  ILE A 203  1  O  GLN A 199   N  ILE A 171
SHEET    3 AA2 3 VAL A 252  ALA A 258 -1  O  ARG A 256   N  PHE A 200
SHEET    1 AA3 6 VAL B  23  THR B  27  0
SHEET    2 AA3 6 ALA B  36  PRO B  42 -1  O  VAL B  39   N  PHE B  26
SHEET    3 AA3 6 VAL B  78  ASP B  83 -1  O  VAL B  79   N  TYR B  40
SHEET    4 AA3 6 VAL B  49  VAL B  55  1  N  ILE B  54   O  ILE B  80
SHEET    5 AA3 6 VAL B 120  GLY B 129  1  O  ASP B 121   N  VAL B  49
SHEET    6 AA3 6 ALA B 149  ALA B 150  1  O  ALA B 149   N  VAL B 127
SHEET    1 AA4 3 THR B 169  CYS B 174  0
SHEET    2 AA4 3 LYS B 198  ILE B 203  1  O  ILE B 203   N  ALA B 173
SHEET    3 AA4 3 VAL B 252  ALA B 258 -1  O  ARG B 256   N  PHE B 200
SHEET    1 AA5 6 THR C  22  THR C  27  0
SHEET    2 AA5 6 ALA C  36  THR C  43 -1  O  VAL C  39   N  PHE C  26
SHEET    3 AA5 6 VAL C  78  ASP C  83 -1  O  VAL C  79   N  TYR C  40
SHEET    4 AA5 6 VAL C  49  VAL C  55  1  N  ILE C  52   O  ILE C  80
SHEET    5 AA5 6 VAL C 120  TRP C 130  1  O  ASP C 121   N  VAL C  49
SHEET    6 AA5 6 ALA C 149  GLN C 153  1  O  GLN C 153   N  GLY C 129
SHEET    1 AA6 3 THR C 169  CYS C 174  0
SHEET    2 AA6 3 LYS C 198  ILE C 203  1  O  GLN C 199   N  ILE C 171
SHEET    3 AA6 3 VAL C 252  ALA C 258 -1  O  ARG C 256   N  PHE C 200
SSBOND   1 CYS A  174    CYS A  210                          1555   1555  2.04
SSBOND   2 CYS A  244    CYS A  260                          1555   1555  2.04
SSBOND   3 CYS B  174    CYS B  210                          1555   1555  2.03
SSBOND   4 CYS B  244    CYS B  260                          1555   1555  2.05
SSBOND   5 CYS C  174    CYS C  210                          1555   1555  2.06
SSBOND   6 CYS C  244    CYS C  260                          1555   1555  2.07
CRYST1   52.560  233.800  163.690  90.00  90.00  90.00 C 2 2 21     24
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.019026  0.000000  0.000000        0.00000
SCALE2      0.000000  0.004277  0.000000        0.00000
SCALE3      0.000000  0.000000  0.006109        0.00000
TER    1924      SER A 261
TER    3848      SER B 261
TER    5772      SER C 261
MASTER      325    0    0   28   27    0    0    6 6530    3   12   63
END