longtext: 8oe2-pdb

content
HEADER    HYDROLASE                               10-MAR-23   8OE2
TITLE     STRUCTURE OF HYPERSTABLE HALOALKANE DEHALOGENASE VARIANT DHAA223
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: HALOALKANE DEHALOGENASE;
COMPND   3 CHAIN: A, B, C, D, E, F;
COMPND   4 EC: 3.8.1.5;
COMPND   5 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT;
SOURCE   3 ORGANISM_TAXID: 32630;
SOURCE   4 GENE: DHAA;
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 562
KEYWDS    ENGINEERED HALOALKANE DEHALOGENASE, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    M.MAREK
REVDAT   1   17-JAN-24 8OE2    0
JRNL        AUTH   A.KUNKA,S.M.MARQUES,M.HAVLASEK,M.VASINA,N.VELATOVA,
JRNL        AUTH 2 L.CENGELOVA,D.KOVAR,J.DAMBORSKY,M.MAREK,D.BEDNAR,Z.PROKOP
JRNL        TITL   ADVANCING ENZYME'S STABILITY AND CATALYTIC EFFICIENCY
JRNL        TITL 2 THROUGH SYNERGY OF FORCE-FIELD CALCULATIONS, EVOLUTIONARY
JRNL        TITL 3 ANALYSIS, AND MACHINE LEARNING.
JRNL        REF    ACS CATALYSIS                 V.  13 12506 2023
JRNL        REFN                   ESSN 2155-5435
JRNL        PMID   37822856
JRNL        DOI    10.1021/ACSCATAL.3C02575
REMARK   2
REMARK   2 RESOLUTION.    1.51 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX 1.20.1-4487
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : ML
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.51
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 47.72
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.340
REMARK   3   COMPLETENESS FOR RANGE        (%) : 98.1
REMARK   3   NUMBER OF REFLECTIONS             : 295797
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.170
REMARK   3   R VALUE            (WORKING SET) : 0.168
REMARK   3   FREE R VALUE                     : 0.195
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.950
REMARK   3   FREE R VALUE TEST SET COUNT      : 14654
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 47.7200 -  4.6781    0.96     9293   516  0.1686 0.1858
REMARK   3     2  4.6781 -  3.7136    0.98     9380   490  0.1377 0.1519
REMARK   3     3  3.7136 -  3.2443    0.98     9398   450  0.1494 0.1707
REMARK   3     4  3.2443 -  2.9477    0.99     9486   503  0.1576 0.1733
REMARK   3     5  2.9477 -  2.7364    0.99     9425   479  0.1555 0.1940
REMARK   3     6  2.7364 -  2.5751    0.96     9222   489  0.1587 0.1756
REMARK   3     7  2.5751 -  2.4462    0.98     9309   493  0.1553 0.1889
REMARK   3     8  2.4462 -  2.3397    0.98     9391   516  0.1573 0.1886
REMARK   3     9  2.3397 -  2.2496    0.98     9342   502  0.1544 0.1806
REMARK   3    10  2.2496 -  2.1720    0.98     9406   447  0.1540 0.1824
REMARK   3    11  2.1720 -  2.1041    0.99     9459   493  0.1519 0.1781
REMARK   3    12  2.1041 -  2.0439    0.99     9408   518  0.1541 0.1915
REMARK   3    13  2.0439 -  1.9901    0.99     9542   505  0.1522 0.1897
REMARK   3    14  1.9901 -  1.9416    0.99     9467   462  0.1546 0.1809
REMARK   3    15  1.9416 -  1.8974    0.98     9366   489  0.1722 0.1971
REMARK   3    16  1.8974 -  1.8570    0.97     9232   460  0.1686 0.2042
REMARK   3    17  1.8570 -  1.8199    0.96     9202   488  0.1766 0.2140
REMARK   3    18  1.8199 -  1.7855    0.98     9334   471  0.1784 0.2180
REMARK   3    19  1.7855 -  1.7537    0.99     9510   430  0.1875 0.2374
REMARK   3    20  1.7537 -  1.7239    0.99     9327   506  0.1920 0.2254
REMARK   3    21  1.7239 -  1.6961    0.99     9464   525  0.2006 0.2364
REMARK   3    22  1.6961 -  1.6700    0.99     9455   444  0.2036 0.2272
REMARK   3    23  1.6700 -  1.6455    0.99     9445   468  0.2109 0.2293
REMARK   3    24  1.6455 -  1.6223    0.99     9368   564  0.2182 0.2617
REMARK   3    25  1.6223 -  1.6004    0.99     9452   500  0.2216 0.2520
REMARK   3    26  1.6004 -  1.5796    0.99     9449   501  0.2363 0.2678
REMARK   3    27  1.5796 -  1.5598    0.99     9350   515  0.2474 0.2881
REMARK   3    28  1.5598 -  1.5410    0.98     9429   482  0.2691 0.2910
REMARK   3    29  1.5410 -  1.5231    0.97     9197   465  0.2902 0.3107
REMARK   3    30  1.5231 -  1.5100    0.95     9035   483  0.3143 0.3354
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL
REMARK   3   SOLVENT RADIUS     : 1.11
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.160
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 21.440
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :  0.017          15185
REMARK   3   ANGLE     :  1.427          20766
REMARK   3   CHIRALITY :  0.093           2130
REMARK   3   PLANARITY :  0.012           2700
REMARK   3   DIHEDRAL  :  7.303          12351
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : 1
REMARK   3   TLS GROUP : 1
REMARK   3    SELECTION: ALL
REMARK   3    ORIGIN FOR THE GROUP (A):  21.1346  23.7350 -20.4705
REMARK   3    T TENSOR
REMARK   3      T11:   0.0916 T22:   0.0946
REMARK   3      T33:   0.1086 T12:   0.0008
REMARK   3      T13:   0.0031 T23:  -0.0057
REMARK   3    L TENSOR
REMARK   3      L11:   0.0191 L22:   0.0196
REMARK   3      L33:   0.0202 L12:   0.0037
REMARK   3      L13:   0.0002 L23:  -0.0062
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0041 S12:  -0.0068 S13:   0.0026
REMARK   3      S21:   0.0011 S22:   0.0015 S23:   0.0027
REMARK   3      S31:   0.0018 S32:   0.0023 S33:  -0.0000
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 8OE2 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 10-MAR-23.
REMARK 100 THE DEPOSITION ID IS D_1292129110.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 07-OCT-22
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 5.5
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : SLS
REMARK 200  BEAMLINE                       : X06SA
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.999
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : PIXEL
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS EIGER X 16M
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200  DATA SCALING SOFTWARE          : AIMLESS
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 296214
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.510
REMARK 200  RESOLUTION RANGE LOW       (A) : 47.720
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 98.2
REMARK 200  DATA REDUNDANCY                : 3.500
REMARK 200  R MERGE                    (I) : NULL
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 7.2000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.51
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.53
REMARK 200  COMPLETENESS FOR SHELL     (%) : NULL
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL
REMARK 200  R MERGE FOR SHELL          (I) : NULL
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 1.100
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 47.61
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.35
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: AMMONIUM SULPHATE, BIS-TRIS, PEG 3350,
REMARK 280  PH 5.5, VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 293.15K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000       71.57200
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2, 3, 4, 5, 6
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 3
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 4
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: D
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 5
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: E
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 6
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: F
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A     1
REMARK 465     SER A     2
REMARK 465     HIS A   296
REMARK 465     HIS A   297
REMARK 465     HIS A   298
REMARK 465     HIS A   299
REMARK 465     MET B     1
REMARK 465     ALA B   292
REMARK 465     LEU B   293
REMARK 465     HIS B   294
REMARK 465     HIS B   295
REMARK 465     HIS B   296
REMARK 465     HIS B   297
REMARK 465     HIS B   298
REMARK 465     HIS B   299
REMARK 465     MET C     1
REMARK 465     SER C     2
REMARK 465     HIS C   295
REMARK 465     HIS C   296
REMARK 465     HIS C   297
REMARK 465     HIS C   298
REMARK 465     HIS C   299
REMARK 465     MET D     1
REMARK 465     HIS D   295
REMARK 465     HIS D   296
REMARK 465     HIS D   297
REMARK 465     HIS D   298
REMARK 465     HIS D   299
REMARK 465     MET E     1
REMARK 465     SER E     2
REMARK 465     ALA E   292
REMARK 465     LEU E   293
REMARK 465     HIS E   294
REMARK 465     HIS E   295
REMARK 465     HIS E   296
REMARK 465     HIS E   297
REMARK 465     HIS E   298
REMARK 465     HIS E   299
REMARK 465     MET F     1
REMARK 465     SER F     2
REMARK 465     HIS F   294
REMARK 465     HIS F   295
REMARK 465     HIS F   296
REMARK 465     HIS F   297
REMARK 465     HIS F   298
REMARK 465     HIS F   299
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION
REMARK 500    SER D 232   C     PRO D 233   N       0.123
REMARK 500    TYR F 165   CE2   TYR F 165   CD2     0.124
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    ASP A 217   CB  -  CG  -  OD1 ANGL. DEV. =   5.9 DEGREES
REMARK 500    ASP B 217   CB  -  CG  -  OD1 ANGL. DEV. =   6.2 DEGREES
REMARK 500    ARG F  30   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.7 DEGREES
REMARK 500    ARG F 199   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.1 DEGREES
REMARK 500    ASP F 217   CB  -  CG  -  OD1 ANGL. DEV. =   5.8 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    ASP A  31     -163.04   -126.48
REMARK 500    PRO A  42       45.04   -107.25
REMARK 500    THR A  43     -156.51   -101.70
REMARK 500    SER A  44     -169.40   -164.26
REMARK 500    GLU A  98      -83.92   -103.11
REMARK 500    ASP A 106     -134.49     52.78
REMARK 500    ASP A 156      -53.17     71.01
REMARK 500    VAL A 245      -68.51   -134.47
REMARK 500    LEU A 271      -91.58   -116.06
REMARK 500    ASP B  31     -164.96   -126.45
REMARK 500    PRO B  42       47.78   -104.46
REMARK 500    THR B  43     -158.34   -105.05
REMARK 500    SER B  44     -168.43   -161.97
REMARK 500    GLU B  98      -93.16   -107.58
REMARK 500    ASP B 106     -133.62     53.27
REMARK 500    ASP B 156      -52.64     68.79
REMARK 500    VAL B 245      -65.51   -134.37
REMARK 500    LEU B 271      -95.36   -117.39
REMARK 500    ASP C  31     -160.49   -122.27
REMARK 500    PRO C  42       45.00   -107.13
REMARK 500    THR C  43     -158.45   -102.05
REMARK 500    SER C  44     -164.13   -162.26
REMARK 500    GLU C  98      -86.43   -107.80
REMARK 500    ASP C 106     -135.55     53.12
REMARK 500    ASP C 156      -52.24     67.79
REMARK 500    VAL C 245      -68.36   -132.64
REMARK 500    LEU C 271      -94.33   -115.50
REMARK 500    ASP D  31     -164.84   -127.71
REMARK 500    PRO D  42       46.50   -107.13
REMARK 500    THR D  43     -154.32   -103.66
REMARK 500    GLU D  98      -87.51   -104.99
REMARK 500    ASP D 106     -134.04     53.93
REMARK 500    ASP D 156      -53.39     69.40
REMARK 500    VAL D 245      -70.11   -133.48
REMARK 500    LEU D 271      -94.51   -116.17
REMARK 500    LEU D 293        9.16    -68.49
REMARK 500    ASP E  31     -162.91   -127.07
REMARK 500    PRO E  42       44.79   -103.41
REMARK 500    THR E  43     -152.28   -104.00
REMARK 500    GLU E  98      -89.14   -104.94
REMARK 500    ASP E 106     -134.57     51.16
REMARK 500    ASP E 156      -54.98     71.15
REMARK 500    ILE E 171      -61.49   -104.75
REMARK 500    VAL E 245      -67.11   -129.57
REMARK 500    LEU E 271      -98.97   -113.96
REMARK 500    PRO F  42       44.60   -101.97
REMARK 500    THR F  43     -155.38   -105.41
REMARK 500    GLU F  98      -92.86   -112.44
REMARK 500    ASP F 106     -133.70     53.24
REMARK 500    ASP F 156      -54.34     71.52
REMARK 500
REMARK 500 THIS ENTRY HAS      52 RAMACHANDRAN OUTLIERS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 525
REMARK 525 SOLVENT
REMARK 525
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 525 NUMBER; I=INSERTION CODE):
REMARK 525
REMARK 525  M RES CSSEQI
REMARK 525    HOH A 760        DISTANCE =  5.83 ANGSTROMS
REMARK 525    HOH A 761        DISTANCE =  6.03 ANGSTROMS
REMARK 525    HOH A 762        DISTANCE =  6.36 ANGSTROMS
REMARK 525    HOH A 763        DISTANCE =  6.53 ANGSTROMS
REMARK 525    HOH A 764        DISTANCE =  6.54 ANGSTROMS
REMARK 525    HOH A 765        DISTANCE =  6.75 ANGSTROMS
REMARK 525    HOH A 766        DISTANCE =  6.93 ANGSTROMS
REMARK 525    HOH B 712        DISTANCE =  6.04 ANGSTROMS
REMARK 525    HOH B 713        DISTANCE =  6.22 ANGSTROMS
REMARK 525    HOH B 714        DISTANCE =  7.11 ANGSTROMS
REMARK 525    HOH B 715        DISTANCE =  8.76 ANGSTROMS
REMARK 525    HOH C 711        DISTANCE =  5.88 ANGSTROMS
REMARK 525    HOH C 712        DISTANCE =  6.00 ANGSTROMS
REMARK 525    HOH C 713        DISTANCE =  6.10 ANGSTROMS
REMARK 525    HOH C 714        DISTANCE =  6.23 ANGSTROMS
REMARK 525    HOH C 715        DISTANCE =  6.54 ANGSTROMS
REMARK 525    HOH D 680        DISTANCE =  6.25 ANGSTROMS
REMARK 525    HOH D 681        DISTANCE =  6.45 ANGSTROMS
REMARK 525    HOH D 682        DISTANCE =  6.53 ANGSTROMS
REMARK 525    HOH D 683        DISTANCE =  6.86 ANGSTROMS
REMARK 525    HOH E 708        DISTANCE =  6.30 ANGSTROMS
REMARK 525    HOH F 666        DISTANCE =  6.34 ANGSTROMS
DBREF  8OE2 A    1   293  UNP    P0A3G4   DHAA_PSEPV       1    293
DBREF  8OE2 B    1   293  UNP    P0A3G4   DHAA_PSEPV       1    293
DBREF  8OE2 C    1   293  UNP    P0A3G4   DHAA_PSEPV       1    293
DBREF  8OE2 D    1   293  UNP    P0A3G4   DHAA_PSEPV       1    293
DBREF  8OE2 E    1   293  UNP    P0A3G4   DHAA_PSEPV       1    293
DBREF  8OE2 F    1   293  UNP    P0A3G4   DHAA_PSEPV       1    293
SEQADV 8OE2 SER A   20  UNP  P0A3G4    GLU    20 CONFLICT
SEQADV 8OE2 ARG A   80  UNP  P0A3G4    PHE    80 CONFLICT
SEQADV 8OE2 PHE A  128  UNP  P0A3G4    CYS   128 CONFLICT
SEQADV 8OE2 LEU A  148  UNP  P0A3G4    THR   148 CONFLICT
SEQADV 8OE2 PRO A  155  UNP  P0A3G4    ALA   155 CONFLICT
SEQADV 8OE2 TYR A  165  UNP  P0A3G4    GLN   165 CONFLICT
SEQADV 8OE2 ILE A  171  UNP  P0A3G4    GLY   171 CONFLICT
SEQADV 8OE2 ILE A  172  UNP  P0A3G4    ALA   172 CONFLICT
SEQADV 8OE2 PHE A  176  UNP  P0A3G4    CYS   176 CONFLICT
SEQADV 8OE2 GLU A  184  UNP  P0A3G4    VAL   184 CONFLICT
SEQADV 8OE2 GLU A  197  UNP  P0A3G4    VAL   197 CONFLICT
SEQADV 8OE2 TRP A  198  UNP  P0A3G4    ASP   198 CONFLICT
SEQADV 8OE2 ASN A  212  UNP  P0A3G4    ALA   212 CONFLICT
SEQADV 8OE2 ASP A  217  UNP  P0A3G4    ASN   217 CONFLICT
SEQADV 8OE2 TRP A  219  UNP  P0A3G4    VAL   219 CONFLICT
SEQADV 8OE2 LEU A  262  UNP  P0A3G4    CYS   262 CONFLICT
SEQADV 8OE2 PHE A  266  UNP  P0A3G4    ASP   266 CONFLICT
SEQADV 8OE2 HIS A  294  UNP  P0A3G4              EXPRESSION TAG
SEQADV 8OE2 HIS A  295  UNP  P0A3G4              EXPRESSION TAG
SEQADV 8OE2 HIS A  296  UNP  P0A3G4              EXPRESSION TAG
SEQADV 8OE2 HIS A  297  UNP  P0A3G4              EXPRESSION TAG
SEQADV 8OE2 HIS A  298  UNP  P0A3G4              EXPRESSION TAG
SEQADV 8OE2 HIS A  299  UNP  P0A3G4              EXPRESSION TAG
SEQADV 8OE2 SER B   20  UNP  P0A3G4    GLU    20 CONFLICT
SEQADV 8OE2 ARG B   80  UNP  P0A3G4    PHE    80 CONFLICT
SEQADV 8OE2 PHE B  128  UNP  P0A3G4    CYS   128 CONFLICT
SEQADV 8OE2 LEU B  148  UNP  P0A3G4    THR   148 CONFLICT
SEQADV 8OE2 PRO B  155  UNP  P0A3G4    ALA   155 CONFLICT
SEQADV 8OE2 TYR B  165  UNP  P0A3G4    GLN   165 CONFLICT
SEQADV 8OE2 ILE B  171  UNP  P0A3G4    GLY   171 CONFLICT
SEQADV 8OE2 ILE B  172  UNP  P0A3G4    ALA   172 CONFLICT
SEQADV 8OE2 PHE B  176  UNP  P0A3G4    CYS   176 CONFLICT
SEQADV 8OE2 GLU B  184  UNP  P0A3G4    VAL   184 CONFLICT
SEQADV 8OE2 GLU B  197  UNP  P0A3G4    VAL   197 CONFLICT
SEQADV 8OE2 TRP B  198  UNP  P0A3G4    ASP   198 CONFLICT
SEQADV 8OE2 ASN B  212  UNP  P0A3G4    ALA   212 CONFLICT
SEQADV 8OE2 ASP B  217  UNP  P0A3G4    ASN   217 CONFLICT
SEQADV 8OE2 TRP B  219  UNP  P0A3G4    VAL   219 CONFLICT
SEQADV 8OE2 LEU B  262  UNP  P0A3G4    CYS   262 CONFLICT
SEQADV 8OE2 PHE B  266  UNP  P0A3G4    ASP   266 CONFLICT
SEQADV 8OE2 HIS B  294  UNP  P0A3G4              EXPRESSION TAG
SEQADV 8OE2 HIS B  295  UNP  P0A3G4              EXPRESSION TAG
SEQADV 8OE2 HIS B  296  UNP  P0A3G4              EXPRESSION TAG
SEQADV 8OE2 HIS B  297  UNP  P0A3G4              EXPRESSION TAG
SEQADV 8OE2 HIS B  298  UNP  P0A3G4              EXPRESSION TAG
SEQADV 8OE2 HIS B  299  UNP  P0A3G4              EXPRESSION TAG
SEQADV 8OE2 SER C   20  UNP  P0A3G4    GLU    20 CONFLICT
SEQADV 8OE2 ARG C   80  UNP  P0A3G4    PHE    80 CONFLICT
SEQADV 8OE2 PHE C  128  UNP  P0A3G4    CYS   128 CONFLICT
SEQADV 8OE2 LEU C  148  UNP  P0A3G4    THR   148 CONFLICT
SEQADV 8OE2 PRO C  155  UNP  P0A3G4    ALA   155 CONFLICT
SEQADV 8OE2 TYR C  165  UNP  P0A3G4    GLN   165 CONFLICT
SEQADV 8OE2 ILE C  171  UNP  P0A3G4    GLY   171 CONFLICT
SEQADV 8OE2 ILE C  172  UNP  P0A3G4    ALA   172 CONFLICT
SEQADV 8OE2 PHE C  176  UNP  P0A3G4    CYS   176 CONFLICT
SEQADV 8OE2 GLU C  184  UNP  P0A3G4    VAL   184 CONFLICT
SEQADV 8OE2 GLU C  197  UNP  P0A3G4    VAL   197 CONFLICT
SEQADV 8OE2 TRP C  198  UNP  P0A3G4    ASP   198 CONFLICT
SEQADV 8OE2 ASN C  212  UNP  P0A3G4    ALA   212 CONFLICT
SEQADV 8OE2 ASP C  217  UNP  P0A3G4    ASN   217 CONFLICT
SEQADV 8OE2 TRP C  219  UNP  P0A3G4    VAL   219 CONFLICT
SEQADV 8OE2 LEU C  262  UNP  P0A3G4    CYS   262 CONFLICT
SEQADV 8OE2 PHE C  266  UNP  P0A3G4    ASP   266 CONFLICT
SEQADV 8OE2 HIS C  294  UNP  P0A3G4              EXPRESSION TAG
SEQADV 8OE2 HIS C  295  UNP  P0A3G4              EXPRESSION TAG
SEQADV 8OE2 HIS C  296  UNP  P0A3G4              EXPRESSION TAG
SEQADV 8OE2 HIS C  297  UNP  P0A3G4              EXPRESSION TAG
SEQADV 8OE2 HIS C  298  UNP  P0A3G4              EXPRESSION TAG
SEQADV 8OE2 HIS C  299  UNP  P0A3G4              EXPRESSION TAG
SEQADV 8OE2 SER D   20  UNP  P0A3G4    GLU    20 CONFLICT
SEQADV 8OE2 ARG D   80  UNP  P0A3G4    PHE    80 CONFLICT
SEQADV 8OE2 PHE D  128  UNP  P0A3G4    CYS   128 CONFLICT
SEQADV 8OE2 LEU D  148  UNP  P0A3G4    THR   148 CONFLICT
SEQADV 8OE2 PRO D  155  UNP  P0A3G4    ALA   155 CONFLICT
SEQADV 8OE2 TYR D  165  UNP  P0A3G4    GLN   165 CONFLICT
SEQADV 8OE2 ILE D  171  UNP  P0A3G4    GLY   171 CONFLICT
SEQADV 8OE2 ILE D  172  UNP  P0A3G4    ALA   172 CONFLICT
SEQADV 8OE2 PHE D  176  UNP  P0A3G4    CYS   176 CONFLICT
SEQADV 8OE2 GLU D  184  UNP  P0A3G4    VAL   184 CONFLICT
SEQADV 8OE2 GLU D  197  UNP  P0A3G4    VAL   197 CONFLICT
SEQADV 8OE2 TRP D  198  UNP  P0A3G4    ASP   198 CONFLICT
SEQADV 8OE2 ASN D  212  UNP  P0A3G4    ALA   212 CONFLICT
SEQADV 8OE2 ASP D  217  UNP  P0A3G4    ASN   217 CONFLICT
SEQADV 8OE2 TRP D  219  UNP  P0A3G4    VAL   219 CONFLICT
SEQADV 8OE2 LEU D  262  UNP  P0A3G4    CYS   262 CONFLICT
SEQADV 8OE2 PHE D  266  UNP  P0A3G4    ASP   266 CONFLICT
SEQADV 8OE2 HIS D  294  UNP  P0A3G4              EXPRESSION TAG
SEQADV 8OE2 HIS D  295  UNP  P0A3G4              EXPRESSION TAG
SEQADV 8OE2 HIS D  296  UNP  P0A3G4              EXPRESSION TAG
SEQADV 8OE2 HIS D  297  UNP  P0A3G4              EXPRESSION TAG
SEQADV 8OE2 HIS D  298  UNP  P0A3G4              EXPRESSION TAG
SEQADV 8OE2 HIS D  299  UNP  P0A3G4              EXPRESSION TAG
SEQADV 8OE2 SER E   20  UNP  P0A3G4    GLU    20 CONFLICT
SEQADV 8OE2 ARG E   80  UNP  P0A3G4    PHE    80 CONFLICT
SEQADV 8OE2 PHE E  128  UNP  P0A3G4    CYS   128 CONFLICT
SEQADV 8OE2 LEU E  148  UNP  P0A3G4    THR   148 CONFLICT
SEQADV 8OE2 PRO E  155  UNP  P0A3G4    ALA   155 CONFLICT
SEQADV 8OE2 TYR E  165  UNP  P0A3G4    GLN   165 CONFLICT
SEQADV 8OE2 ILE E  171  UNP  P0A3G4    GLY   171 CONFLICT
SEQADV 8OE2 ILE E  172  UNP  P0A3G4    ALA   172 CONFLICT
SEQADV 8OE2 PHE E  176  UNP  P0A3G4    CYS   176 CONFLICT
SEQADV 8OE2 GLU E  184  UNP  P0A3G4    VAL   184 CONFLICT
SEQADV 8OE2 GLU E  197  UNP  P0A3G4    VAL   197 CONFLICT
SEQADV 8OE2 TRP E  198  UNP  P0A3G4    ASP   198 CONFLICT
SEQADV 8OE2 ASN E  212  UNP  P0A3G4    ALA   212 CONFLICT
SEQADV 8OE2 ASP E  217  UNP  P0A3G4    ASN   217 CONFLICT
SEQADV 8OE2 TRP E  219  UNP  P0A3G4    VAL   219 CONFLICT
SEQADV 8OE2 LEU E  262  UNP  P0A3G4    CYS   262 CONFLICT
SEQADV 8OE2 PHE E  266  UNP  P0A3G4    ASP   266 CONFLICT
SEQADV 8OE2 HIS E  294  UNP  P0A3G4              EXPRESSION TAG
SEQADV 8OE2 HIS E  295  UNP  P0A3G4              EXPRESSION TAG
SEQADV 8OE2 HIS E  296  UNP  P0A3G4              EXPRESSION TAG
SEQADV 8OE2 HIS E  297  UNP  P0A3G4              EXPRESSION TAG
SEQADV 8OE2 HIS E  298  UNP  P0A3G4              EXPRESSION TAG
SEQADV 8OE2 HIS E  299  UNP  P0A3G4              EXPRESSION TAG
SEQADV 8OE2 SER F   20  UNP  P0A3G4    GLU    20 CONFLICT
SEQADV 8OE2 ARG F   80  UNP  P0A3G4    PHE    80 CONFLICT
SEQADV 8OE2 PHE F  128  UNP  P0A3G4    CYS   128 CONFLICT
SEQADV 8OE2 LEU F  148  UNP  P0A3G4    THR   148 CONFLICT
SEQADV 8OE2 PRO F  155  UNP  P0A3G4    ALA   155 CONFLICT
SEQADV 8OE2 TYR F  165  UNP  P0A3G4    GLN   165 CONFLICT
SEQADV 8OE2 ILE F  171  UNP  P0A3G4    GLY   171 CONFLICT
SEQADV 8OE2 ILE F  172  UNP  P0A3G4    ALA   172 CONFLICT
SEQADV 8OE2 PHE F  176  UNP  P0A3G4    CYS   176 CONFLICT
SEQADV 8OE2 GLU F  184  UNP  P0A3G4    VAL   184 CONFLICT
SEQADV 8OE2 GLU F  197  UNP  P0A3G4    VAL   197 CONFLICT
SEQADV 8OE2 TRP F  198  UNP  P0A3G4    ASP   198 CONFLICT
SEQADV 8OE2 ASN F  212  UNP  P0A3G4    ALA   212 CONFLICT
SEQADV 8OE2 ASP F  217  UNP  P0A3G4    ASN   217 CONFLICT
SEQADV 8OE2 TRP F  219  UNP  P0A3G4    VAL   219 CONFLICT
SEQADV 8OE2 LEU F  262  UNP  P0A3G4    CYS   262 CONFLICT
SEQADV 8OE2 PHE F  266  UNP  P0A3G4    ASP   266 CONFLICT
SEQADV 8OE2 HIS F  294  UNP  P0A3G4              EXPRESSION TAG
SEQADV 8OE2 HIS F  295  UNP  P0A3G4              EXPRESSION TAG
SEQADV 8OE2 HIS F  296  UNP  P0A3G4              EXPRESSION TAG
SEQADV 8OE2 HIS F  297  UNP  P0A3G4              EXPRESSION TAG
SEQADV 8OE2 HIS F  298  UNP  P0A3G4              EXPRESSION TAG
SEQADV 8OE2 HIS F  299  UNP  P0A3G4              EXPRESSION TAG
SEQRES   1 A  299  MET SER GLU ILE GLY THR GLY PHE PRO PHE ASP PRO HIS
SEQRES   2 A  299  TYR VAL GLU VAL LEU GLY SER ARG MET HIS TYR VAL ASP
SEQRES   3 A  299  VAL GLY PRO ARG ASP GLY THR PRO VAL LEU PHE LEU HIS
SEQRES   4 A  299  GLY ASN PRO THR SER SER TYR LEU TRP ARG ASN ILE ILE
SEQRES   5 A  299  PRO HIS VAL ALA PRO SER HIS ARG CYS ILE ALA PRO ASP
SEQRES   6 A  299  LEU ILE GLY MET GLY LYS SER ASP LYS PRO ASP LEU ASP
SEQRES   7 A  299  TYR ARG PHE ASP ASP HIS VAL ARG TYR LEU ASP ALA PHE
SEQRES   8 A  299  ILE GLU ALA LEU GLY LEU GLU GLU VAL VAL LEU VAL ILE
SEQRES   9 A  299  HIS ASP TRP GLY SER ALA LEU GLY PHE HIS TRP ALA LYS
SEQRES  10 A  299  ARG ASN PRO GLU ARG VAL LYS GLY ILE ALA PHE MET GLU
SEQRES  11 A  299  PHE ILE ARG PRO ILE PRO THR TRP ASP GLU TRP PRO GLU
SEQRES  12 A  299  PHE ALA ARG GLU LEU PHE GLN ALA PHE ARG THR PRO ASP
SEQRES  13 A  299  VAL GLY ARG GLU LEU ILE ILE ASP TYR ASN ALA PHE ILE
SEQRES  14 A  299  GLU ILE ILE LEU PRO LYS PHE VAL VAL ARG PRO LEU THR
SEQRES  15 A  299  GLU GLU GLU MET ASP HIS TYR ARG GLU PRO PHE LEU LYS
SEQRES  16 A  299  PRO GLU TRP ARG GLU PRO LEU TRP ARG PHE PRO ASN GLU
SEQRES  17 A  299  LEU PRO ILE ASN GLY GLU PRO ALA ASP ILE TRP ALA LEU
SEQRES  18 A  299  VAL GLU ALA TYR MET ASN TRP LEU HIS GLN SER PRO VAL
SEQRES  19 A  299  PRO LYS LEU LEU PHE TRP GLY THR PRO GLY VAL LEU ILE
SEQRES  20 A  299  PRO PRO ALA GLU ALA ALA ARG LEU ALA GLU SER LEU PRO
SEQRES  21 A  299  ASN LEU LYS THR VAL PHE ILE GLY PRO GLY LEU HIS TYR
SEQRES  22 A  299  LEU GLN GLU ASP ASN PRO ASP LEU ILE GLY SER GLU ILE
SEQRES  23 A  299  ALA ARG TRP LEU PRO ALA LEU HIS HIS HIS HIS HIS HIS
SEQRES   1 B  299  MET SER GLU ILE GLY THR GLY PHE PRO PHE ASP PRO HIS
SEQRES   2 B  299  TYR VAL GLU VAL LEU GLY SER ARG MET HIS TYR VAL ASP
SEQRES   3 B  299  VAL GLY PRO ARG ASP GLY THR PRO VAL LEU PHE LEU HIS
SEQRES   4 B  299  GLY ASN PRO THR SER SER TYR LEU TRP ARG ASN ILE ILE
SEQRES   5 B  299  PRO HIS VAL ALA PRO SER HIS ARG CYS ILE ALA PRO ASP
SEQRES   6 B  299  LEU ILE GLY MET GLY LYS SER ASP LYS PRO ASP LEU ASP
SEQRES   7 B  299  TYR ARG PHE ASP ASP HIS VAL ARG TYR LEU ASP ALA PHE
SEQRES   8 B  299  ILE GLU ALA LEU GLY LEU GLU GLU VAL VAL LEU VAL ILE
SEQRES   9 B  299  HIS ASP TRP GLY SER ALA LEU GLY PHE HIS TRP ALA LYS
SEQRES  10 B  299  ARG ASN PRO GLU ARG VAL LYS GLY ILE ALA PHE MET GLU
SEQRES  11 B  299  PHE ILE ARG PRO ILE PRO THR TRP ASP GLU TRP PRO GLU
SEQRES  12 B  299  PHE ALA ARG GLU LEU PHE GLN ALA PHE ARG THR PRO ASP
SEQRES  13 B  299  VAL GLY ARG GLU LEU ILE ILE ASP TYR ASN ALA PHE ILE
SEQRES  14 B  299  GLU ILE ILE LEU PRO LYS PHE VAL VAL ARG PRO LEU THR
SEQRES  15 B  299  GLU GLU GLU MET ASP HIS TYR ARG GLU PRO PHE LEU LYS
SEQRES  16 B  299  PRO GLU TRP ARG GLU PRO LEU TRP ARG PHE PRO ASN GLU
SEQRES  17 B  299  LEU PRO ILE ASN GLY GLU PRO ALA ASP ILE TRP ALA LEU
SEQRES  18 B  299  VAL GLU ALA TYR MET ASN TRP LEU HIS GLN SER PRO VAL
SEQRES  19 B  299  PRO LYS LEU LEU PHE TRP GLY THR PRO GLY VAL LEU ILE
SEQRES  20 B  299  PRO PRO ALA GLU ALA ALA ARG LEU ALA GLU SER LEU PRO
SEQRES  21 B  299  ASN LEU LYS THR VAL PHE ILE GLY PRO GLY LEU HIS TYR
SEQRES  22 B  299  LEU GLN GLU ASP ASN PRO ASP LEU ILE GLY SER GLU ILE
SEQRES  23 B  299  ALA ARG TRP LEU PRO ALA LEU HIS HIS HIS HIS HIS HIS
SEQRES   1 C  299  MET SER GLU ILE GLY THR GLY PHE PRO PHE ASP PRO HIS
SEQRES   2 C  299  TYR VAL GLU VAL LEU GLY SER ARG MET HIS TYR VAL ASP
SEQRES   3 C  299  VAL GLY PRO ARG ASP GLY THR PRO VAL LEU PHE LEU HIS
SEQRES   4 C  299  GLY ASN PRO THR SER SER TYR LEU TRP ARG ASN ILE ILE
SEQRES   5 C  299  PRO HIS VAL ALA PRO SER HIS ARG CYS ILE ALA PRO ASP
SEQRES   6 C  299  LEU ILE GLY MET GLY LYS SER ASP LYS PRO ASP LEU ASP
SEQRES   7 C  299  TYR ARG PHE ASP ASP HIS VAL ARG TYR LEU ASP ALA PHE
SEQRES   8 C  299  ILE GLU ALA LEU GLY LEU GLU GLU VAL VAL LEU VAL ILE
SEQRES   9 C  299  HIS ASP TRP GLY SER ALA LEU GLY PHE HIS TRP ALA LYS
SEQRES  10 C  299  ARG ASN PRO GLU ARG VAL LYS GLY ILE ALA PHE MET GLU
SEQRES  11 C  299  PHE ILE ARG PRO ILE PRO THR TRP ASP GLU TRP PRO GLU
SEQRES  12 C  299  PHE ALA ARG GLU LEU PHE GLN ALA PHE ARG THR PRO ASP
SEQRES  13 C  299  VAL GLY ARG GLU LEU ILE ILE ASP TYR ASN ALA PHE ILE
SEQRES  14 C  299  GLU ILE ILE LEU PRO LYS PHE VAL VAL ARG PRO LEU THR
SEQRES  15 C  299  GLU GLU GLU MET ASP HIS TYR ARG GLU PRO PHE LEU LYS
SEQRES  16 C  299  PRO GLU TRP ARG GLU PRO LEU TRP ARG PHE PRO ASN GLU
SEQRES  17 C  299  LEU PRO ILE ASN GLY GLU PRO ALA ASP ILE TRP ALA LEU
SEQRES  18 C  299  VAL GLU ALA TYR MET ASN TRP LEU HIS GLN SER PRO VAL
SEQRES  19 C  299  PRO LYS LEU LEU PHE TRP GLY THR PRO GLY VAL LEU ILE
SEQRES  20 C  299  PRO PRO ALA GLU ALA ALA ARG LEU ALA GLU SER LEU PRO
SEQRES  21 C  299  ASN LEU LYS THR VAL PHE ILE GLY PRO GLY LEU HIS TYR
SEQRES  22 C  299  LEU GLN GLU ASP ASN PRO ASP LEU ILE GLY SER GLU ILE
SEQRES  23 C  299  ALA ARG TRP LEU PRO ALA LEU HIS HIS HIS HIS HIS HIS
SEQRES   1 D  299  MET SER GLU ILE GLY THR GLY PHE PRO PHE ASP PRO HIS
SEQRES   2 D  299  TYR VAL GLU VAL LEU GLY SER ARG MET HIS TYR VAL ASP
SEQRES   3 D  299  VAL GLY PRO ARG ASP GLY THR PRO VAL LEU PHE LEU HIS
SEQRES   4 D  299  GLY ASN PRO THR SER SER TYR LEU TRP ARG ASN ILE ILE
SEQRES   5 D  299  PRO HIS VAL ALA PRO SER HIS ARG CYS ILE ALA PRO ASP
SEQRES   6 D  299  LEU ILE GLY MET GLY LYS SER ASP LYS PRO ASP LEU ASP
SEQRES   7 D  299  TYR ARG PHE ASP ASP HIS VAL ARG TYR LEU ASP ALA PHE
SEQRES   8 D  299  ILE GLU ALA LEU GLY LEU GLU GLU VAL VAL LEU VAL ILE
SEQRES   9 D  299  HIS ASP TRP GLY SER ALA LEU GLY PHE HIS TRP ALA LYS
SEQRES  10 D  299  ARG ASN PRO GLU ARG VAL LYS GLY ILE ALA PHE MET GLU
SEQRES  11 D  299  PHE ILE ARG PRO ILE PRO THR TRP ASP GLU TRP PRO GLU
SEQRES  12 D  299  PHE ALA ARG GLU LEU PHE GLN ALA PHE ARG THR PRO ASP
SEQRES  13 D  299  VAL GLY ARG GLU LEU ILE ILE ASP TYR ASN ALA PHE ILE
SEQRES  14 D  299  GLU ILE ILE LEU PRO LYS PHE VAL VAL ARG PRO LEU THR
SEQRES  15 D  299  GLU GLU GLU MET ASP HIS TYR ARG GLU PRO PHE LEU LYS
SEQRES  16 D  299  PRO GLU TRP ARG GLU PRO LEU TRP ARG PHE PRO ASN GLU
SEQRES  17 D  299  LEU PRO ILE ASN GLY GLU PRO ALA ASP ILE TRP ALA LEU
SEQRES  18 D  299  VAL GLU ALA TYR MET ASN TRP LEU HIS GLN SER PRO VAL
SEQRES  19 D  299  PRO LYS LEU LEU PHE TRP GLY THR PRO GLY VAL LEU ILE
SEQRES  20 D  299  PRO PRO ALA GLU ALA ALA ARG LEU ALA GLU SER LEU PRO
SEQRES  21 D  299  ASN LEU LYS THR VAL PHE ILE GLY PRO GLY LEU HIS TYR
SEQRES  22 D  299  LEU GLN GLU ASP ASN PRO ASP LEU ILE GLY SER GLU ILE
SEQRES  23 D  299  ALA ARG TRP LEU PRO ALA LEU HIS HIS HIS HIS HIS HIS
SEQRES   1 E  299  MET SER GLU ILE GLY THR GLY PHE PRO PHE ASP PRO HIS
SEQRES   2 E  299  TYR VAL GLU VAL LEU GLY SER ARG MET HIS TYR VAL ASP
SEQRES   3 E  299  VAL GLY PRO ARG ASP GLY THR PRO VAL LEU PHE LEU HIS
SEQRES   4 E  299  GLY ASN PRO THR SER SER TYR LEU TRP ARG ASN ILE ILE
SEQRES   5 E  299  PRO HIS VAL ALA PRO SER HIS ARG CYS ILE ALA PRO ASP
SEQRES   6 E  299  LEU ILE GLY MET GLY LYS SER ASP LYS PRO ASP LEU ASP
SEQRES   7 E  299  TYR ARG PHE ASP ASP HIS VAL ARG TYR LEU ASP ALA PHE
SEQRES   8 E  299  ILE GLU ALA LEU GLY LEU GLU GLU VAL VAL LEU VAL ILE
SEQRES   9 E  299  HIS ASP TRP GLY SER ALA LEU GLY PHE HIS TRP ALA LYS
SEQRES  10 E  299  ARG ASN PRO GLU ARG VAL LYS GLY ILE ALA PHE MET GLU
SEQRES  11 E  299  PHE ILE ARG PRO ILE PRO THR TRP ASP GLU TRP PRO GLU
SEQRES  12 E  299  PHE ALA ARG GLU LEU PHE GLN ALA PHE ARG THR PRO ASP
SEQRES  13 E  299  VAL GLY ARG GLU LEU ILE ILE ASP TYR ASN ALA PHE ILE
SEQRES  14 E  299  GLU ILE ILE LEU PRO LYS PHE VAL VAL ARG PRO LEU THR
SEQRES  15 E  299  GLU GLU GLU MET ASP HIS TYR ARG GLU PRO PHE LEU LYS
SEQRES  16 E  299  PRO GLU TRP ARG GLU PRO LEU TRP ARG PHE PRO ASN GLU
SEQRES  17 E  299  LEU PRO ILE ASN GLY GLU PRO ALA ASP ILE TRP ALA LEU
SEQRES  18 E  299  VAL GLU ALA TYR MET ASN TRP LEU HIS GLN SER PRO VAL
SEQRES  19 E  299  PRO LYS LEU LEU PHE TRP GLY THR PRO GLY VAL LEU ILE
SEQRES  20 E  299  PRO PRO ALA GLU ALA ALA ARG LEU ALA GLU SER LEU PRO
SEQRES  21 E  299  ASN LEU LYS THR VAL PHE ILE GLY PRO GLY LEU HIS TYR
SEQRES  22 E  299  LEU GLN GLU ASP ASN PRO ASP LEU ILE GLY SER GLU ILE
SEQRES  23 E  299  ALA ARG TRP LEU PRO ALA LEU HIS HIS HIS HIS HIS HIS
SEQRES   1 F  299  MET SER GLU ILE GLY THR GLY PHE PRO PHE ASP PRO HIS
SEQRES   2 F  299  TYR VAL GLU VAL LEU GLY SER ARG MET HIS TYR VAL ASP
SEQRES   3 F  299  VAL GLY PRO ARG ASP GLY THR PRO VAL LEU PHE LEU HIS
SEQRES   4 F  299  GLY ASN PRO THR SER SER TYR LEU TRP ARG ASN ILE ILE
SEQRES   5 F  299  PRO HIS VAL ALA PRO SER HIS ARG CYS ILE ALA PRO ASP
SEQRES   6 F  299  LEU ILE GLY MET GLY LYS SER ASP LYS PRO ASP LEU ASP
SEQRES   7 F  299  TYR ARG PHE ASP ASP HIS VAL ARG TYR LEU ASP ALA PHE
SEQRES   8 F  299  ILE GLU ALA LEU GLY LEU GLU GLU VAL VAL LEU VAL ILE
SEQRES   9 F  299  HIS ASP TRP GLY SER ALA LEU GLY PHE HIS TRP ALA LYS
SEQRES  10 F  299  ARG ASN PRO GLU ARG VAL LYS GLY ILE ALA PHE MET GLU
SEQRES  11 F  299  PHE ILE ARG PRO ILE PRO THR TRP ASP GLU TRP PRO GLU
SEQRES  12 F  299  PHE ALA ARG GLU LEU PHE GLN ALA PHE ARG THR PRO ASP
SEQRES  13 F  299  VAL GLY ARG GLU LEU ILE ILE ASP TYR ASN ALA PHE ILE
SEQRES  14 F  299  GLU ILE ILE LEU PRO LYS PHE VAL VAL ARG PRO LEU THR
SEQRES  15 F  299  GLU GLU GLU MET ASP HIS TYR ARG GLU PRO PHE LEU LYS
SEQRES  16 F  299  PRO GLU TRP ARG GLU PRO LEU TRP ARG PHE PRO ASN GLU
SEQRES  17 F  299  LEU PRO ILE ASN GLY GLU PRO ALA ASP ILE TRP ALA LEU
SEQRES  18 F  299  VAL GLU ALA TYR MET ASN TRP LEU HIS GLN SER PRO VAL
SEQRES  19 F  299  PRO LYS LEU LEU PHE TRP GLY THR PRO GLY VAL LEU ILE
SEQRES  20 F  299  PRO PRO ALA GLU ALA ALA ARG LEU ALA GLU SER LEU PRO
SEQRES  21 F  299  ASN LEU LYS THR VAL PHE ILE GLY PRO GLY LEU HIS TYR
SEQRES  22 F  299  LEU GLN GLU ASP ASN PRO ASP LEU ILE GLY SER GLU ILE
SEQRES  23 F  299  ALA ARG TRP LEU PRO ALA LEU HIS HIS HIS HIS HIS HIS
HET     CL  A 301       1
HET    SO4  A 302       5
HET    PG4  A 303      13
HET    GOL  A 304       6
HET    GOL  A 305       6
HET    TRS  A 306       8
HET    GOL  A 307       6
HET    GOL  A 308       6
HET     CL  B 301       1
HET    SO4  B 302       5
HET    GOL  B 303       6
HET    GOL  B 304       6
HET     CL  C 301       1
HET    SO4  C 302       5
HET    SO4  C 303       5
HET    GOL  C 304       6
HET     CL  D 301       1
HET    SO4  D 302       5
HET    SO4  D 303       5
HET    PG4  D 304      13
HET    GOL  D 305       6
HET     CL  E 301       1
HET    SO4  E 302       5
HET    GOL  E 303       6
HET    GOL  E 304       6
HET    PG4  E 305      13
HET    GOL  E 306       6
HET     CL  F 301       1
HET    GOL  F 302       6
HETNAM      CL CHLORIDE ION
HETNAM     SO4 SULFATE ION
HETNAM     PG4 TETRAETHYLENE GLYCOL
HETNAM     GOL GLYCEROL
HETNAM     TRS 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
HETSYN     GOL GLYCERIN; PROPANE-1,2,3-TRIOL
HETSYN     TRS TRIS BUFFER
FORMUL   7   CL    6(CL 1-)
FORMUL   8  SO4    7(O4 S 2-)
FORMUL   9  PG4    3(C8 H18 O5)
FORMUL  10  GOL    12(C3 H8 O3)
FORMUL  12  TRS    C4 H12 N O3 1+
FORMUL  36  HOH   *1853(H2 O)
HELIX    1 AA1 SER A   44  ARG A   49  5                                   6
HELIX    2 AA2 ILE A   51  ALA A   56  1                                   6
HELIX    3 AA3 ARG A   80  LEU A   95  1                                  16
HELIX    4 AA4 ASP A  106  ASN A  119  1                                  14
HELIX    5 AA5 THR A  137  TRP A  141  5                                   5
HELIX    6 AA6 PRO A  142  ARG A  153  1                                  12
HELIX    7 AA7 ASP A  156  ILE A  163  1                                   8
HELIX    8 AA8 ASN A  166  ILE A  171  1                                   6
HELIX    9 AA9 ILE A  171  PHE A  176  1                                   6
HELIX   10 AB1 THR A  182  GLU A  191  1                                  10
HELIX   11 AB2 PRO A  192  LEU A  194  5                                   3
HELIX   12 AB3 LYS A  195  TRP A  198  5                                   4
HELIX   13 AB4 ARG A  199  PHE A  205  1                                   7
HELIX   14 AB5 PRO A  206  LEU A  209  5                                   4
HELIX   15 AB6 PRO A  215  SER A  232  1                                  18
HELIX   16 AB7 PRO A  248  LEU A  259  1                                  12
HELIX   17 AB8 TYR A  273  ASP A  277  5                                   5
HELIX   18 AB9 ASN A  278  LEU A  290  1                                  13
HELIX   19 AC1 PRO A  291  HIS A  294  5                                   4
HELIX   20 AC2 SER B   44  ARG B   49  5                                   6
HELIX   21 AC3 ILE B   51  ALA B   56  1                                   6
HELIX   22 AC4 ARG B   80  LEU B   95  1                                  16
HELIX   23 AC5 ASP B  106  ASN B  119  1                                  14
HELIX   24 AC6 THR B  137  TRP B  141  5                                   5
HELIX   25 AC7 PRO B  142  ARG B  153  1                                  12
HELIX   26 AC8 ASP B  156  ASP B  164  1                                   9
HELIX   27 AC9 ASN B  166  ILE B  171  1                                   6
HELIX   28 AD1 ILE B  171  PHE B  176  1                                   6
HELIX   29 AD2 THR B  182  GLU B  191  1                                  10
HELIX   30 AD3 PRO B  192  LEU B  194  5                                   3
HELIX   31 AD4 LYS B  195  TRP B  198  5                                   4
HELIX   32 AD5 ARG B  199  LEU B  209  1                                  11
HELIX   33 AD6 PRO B  215  SER B  232  1                                  18
HELIX   34 AD7 PRO B  248  LEU B  259  1                                  12
HELIX   35 AD8 TYR B  273  ASN B  278  1                                   6
HELIX   36 AD9 ASN B  278  LEU B  290  1                                  13
HELIX   37 AE1 SER C   44  ARG C   49  5                                   6
HELIX   38 AE2 ILE C   51  ALA C   56  1                                   6
HELIX   39 AE3 ARG C   80  GLY C   96  1                                  17
HELIX   40 AE4 ASP C  106  ASN C  119  1                                  14
HELIX   41 AE5 THR C  137  TRP C  141  5                                   5
HELIX   42 AE6 PRO C  142  ARG C  153  1                                  12
HELIX   43 AE7 ASP C  156  ILE C  163  1                                   8
HELIX   44 AE8 ASN C  166  ILE C  171  1                                   6
HELIX   45 AE9 ILE C  171  PHE C  176  1                                   6
HELIX   46 AF1 THR C  182  GLU C  191  1                                  10
HELIX   47 AF2 PRO C  192  LEU C  194  5                                   3
HELIX   48 AF3 LYS C  195  TRP C  198  5                                   4
HELIX   49 AF4 ARG C  199  LEU C  209  1                                  11
HELIX   50 AF5 PRO C  215  SER C  232  1                                  18
HELIX   51 AF6 PRO C  248  LEU C  259  1                                  12
HELIX   52 AF7 TYR C  273  ASN C  278  1                                   6
HELIX   53 AF8 ASN C  278  LEU C  290  1                                  13
HELIX   54 AF9 PRO C  291  HIS C  294  5                                   4
HELIX   55 AG1 SER D   44  ARG D   49  5                                   6
HELIX   56 AG2 ILE D   51  ALA D   56  1                                   6
HELIX   57 AG3 ARG D   80  LEU D   95  1                                  16
HELIX   58 AG4 ASP D  106  ASN D  119  1                                  14
HELIX   59 AG5 THR D  137  TRP D  141  5                                   5
HELIX   60 AG6 PRO D  142  ARG D  153  1                                  12
HELIX   61 AG7 ASP D  156  ILE D  163  1                                   8
HELIX   62 AG8 ASN D  166  ILE D  171  1                                   6
HELIX   63 AG9 ILE D  171  PHE D  176  1                                   6
HELIX   64 AH1 THR D  182  GLU D  191  1                                  10
HELIX   65 AH2 PRO D  192  LEU D  194  5                                   3
HELIX   66 AH3 LYS D  195  TRP D  198  5                                   4
HELIX   67 AH4 ARG D  199  LEU D  209  1                                  11
HELIX   68 AH5 PRO D  215  SER D  232  1                                  18
HELIX   69 AH6 PRO D  248  LEU D  259  1                                  12
HELIX   70 AH7 TYR D  273  ASP D  277  5                                   5
HELIX   71 AH8 ASN D  278  LEU D  290  1                                  13
HELIX   72 AH9 PRO D  291  HIS D  294  5                                   4
HELIX   73 AI1 SER E   44  ARG E   49  5                                   6
HELIX   74 AI2 ILE E   51  ALA E   56  1                                   6
HELIX   75 AI3 ARG E   80  GLY E   96  1                                  17
HELIX   76 AI4 ASP E  106  ASN E  119  1                                  14
HELIX   77 AI5 THR E  137  TRP E  141  5                                   5
HELIX   78 AI6 PRO E  142  ARG E  153  1                                  12
HELIX   79 AI7 ASP E  156  ILE E  163  1                                   8
HELIX   80 AI8 ASN E  166  ILE E  171  1                                   6
HELIX   81 AI9 ILE E  171  PHE E  176  1                                   6
HELIX   82 AJ1 THR E  182  GLU E  191  1                                  10
HELIX   83 AJ2 PRO E  192  LEU E  194  5                                   3
HELIX   84 AJ3 LYS E  195  TRP E  198  5                                   4
HELIX   85 AJ4 ARG E  199  LEU E  209  1                                  11
HELIX   86 AJ5 PRO E  215  SER E  232  1                                  18
HELIX   87 AJ6 PRO E  248  LEU E  259  1                                  12
HELIX   88 AJ7 TYR E  273  ASN E  278  1                                   6
HELIX   89 AJ8 ASN E  278  LEU E  290  1                                  13
HELIX   90 AJ9 SER F   44  ARG F   49  5                                   6
HELIX   91 AK1 ILE F   51  ALA F   56  1                                   6
HELIX   92 AK2 ARG F   80  LEU F   95  1                                  16
HELIX   93 AK3 ASP F  106  ASN F  119  1                                  14
HELIX   94 AK4 THR F  137  TRP F  141  5                                   5
HELIX   95 AK5 PRO F  142  ARG F  153  1                                  12
HELIX   96 AK6 ASP F  156  ILE F  163  1                                   8
HELIX   97 AK7 ASN F  166  ILE F  171  1                                   6
HELIX   98 AK8 ILE F  171  PHE F  176  1                                   6
HELIX   99 AK9 THR F  182  GLU F  191  1                                  10
HELIX  100 AL1 PRO F  192  LEU F  194  5                                   3
HELIX  101 AL2 LYS F  195  TRP F  198  5                                   4
HELIX  102 AL3 ARG F  199  LEU F  209  1                                  11
HELIX  103 AL4 PRO F  215  SER F  232  1                                  18
HELIX  104 AL5 PRO F  248  LEU F  259  1                                  12
HELIX  105 AL6 TYR F  273  ASP F  277  5                                   5
HELIX  106 AL7 ASN F  278  LEU F  290  1                                  13
SHEET    1 AA1 8 HIS A  13  VAL A  17  0
SHEET    2 AA1 8 SER A  20  VAL A  27 -1  O  SER A  20   N  VAL A  17
SHEET    3 AA1 8 CYS A  61  PRO A  64 -1  O  CYS A  61   N  VAL A  27
SHEET    4 AA1 8 VAL A  35  LEU A  38  1  N  PHE A  37   O  ILE A  62
SHEET    5 AA1 8 VAL A 100  HIS A 105  1  O  VAL A 101   N  LEU A  36
SHEET    6 AA1 8 VAL A 123  MET A 129  1  O  ALA A 127   N  LEU A 102
SHEET    7 AA1 8 LYS A 236  PRO A 243  1  O  LEU A 237   N  PHE A 128
SHEET    8 AA1 8 LEU A 262  GLY A 270  1  O  ILE A 267   N  TRP A 240
SHEET    1 AA2 8 HIS B  13  VAL B  17  0
SHEET    2 AA2 8 SER B  20  VAL B  27 -1  O  SER B  20   N  VAL B  17
SHEET    3 AA2 8 CYS B  61  PRO B  64 -1  O  CYS B  61   N  VAL B  27
SHEET    4 AA2 8 VAL B  35  LEU B  38  1  N  VAL B  35   O  ILE B  62
SHEET    5 AA2 8 VAL B 100  HIS B 105  1  O  VAL B 101   N  LEU B  36
SHEET    6 AA2 8 VAL B 123  MET B 129  1  O  LYS B 124   N  VAL B 100
SHEET    7 AA2 8 LYS B 236  PRO B 243  1  O  LEU B 237   N  PHE B 128
SHEET    8 AA2 8 LEU B 262  GLY B 270  1  O  ILE B 267   N  TRP B 240
SHEET    1 AA3 8 HIS C  13  VAL C  17  0
SHEET    2 AA3 8 SER C  20  VAL C  27 -1  O  SER C  20   N  VAL C  17
SHEET    3 AA3 8 CYS C  61  PRO C  64 -1  O  CYS C  61   N  VAL C  27
SHEET    4 AA3 8 VAL C  35  LEU C  38  1  N  VAL C  35   O  ILE C  62
SHEET    5 AA3 8 VAL C 100  HIS C 105  1  O  VAL C 101   N  LEU C  36
SHEET    6 AA3 8 VAL C 123  MET C 129  1  O  ALA C 127   N  LEU C 102
SHEET    7 AA3 8 LYS C 236  PRO C 243  1  O  LEU C 237   N  PHE C 128
SHEET    8 AA3 8 LEU C 262  GLY C 270  1  O  VAL C 265   N  LEU C 238
SHEET    1 AA4 8 HIS D  13  VAL D  17  0
SHEET    2 AA4 8 SER D  20  VAL D  27 -1  O  SER D  20   N  VAL D  17
SHEET    3 AA4 8 CYS D  61  PRO D  64 -1  O  CYS D  61   N  VAL D  27
SHEET    4 AA4 8 VAL D  35  LEU D  38  1  N  VAL D  35   O  ILE D  62
SHEET    5 AA4 8 VAL D 100  HIS D 105  1  O  VAL D 101   N  LEU D  36
SHEET    6 AA4 8 VAL D 123  MET D 129  1  O  ALA D 127   N  LEU D 102
SHEET    7 AA4 8 LYS D 236  PRO D 243  1  O  LEU D 237   N  PHE D 128
SHEET    8 AA4 8 LEU D 262  GLY D 270  1  O  ILE D 267   N  TRP D 240
SHEET    1 AA5 8 HIS E  13  VAL E  17  0
SHEET    2 AA5 8 SER E  20  VAL E  27 -1  O  SER E  20   N  VAL E  17
SHEET    3 AA5 8 CYS E  61  PRO E  64 -1  O  CYS E  61   N  VAL E  27
SHEET    4 AA5 8 VAL E  35  LEU E  38  1  N  PHE E  37   O  ILE E  62
SHEET    5 AA5 8 VAL E 100  HIS E 105  1  O  VAL E 101   N  LEU E  36
SHEET    6 AA5 8 VAL E 123  MET E 129  1  O  ALA E 127   N  LEU E 102
SHEET    7 AA5 8 LYS E 236  PRO E 243  1  O  LEU E 237   N  PHE E 128
SHEET    8 AA5 8 LEU E 262  GLY E 270  1  O  VAL E 265   N  LEU E 238
SHEET    1 AA6 8 HIS F  13  VAL F  17  0
SHEET    2 AA6 8 SER F  20  VAL F  27 -1  O  SER F  20   N  VAL F  17
SHEET    3 AA6 8 CYS F  61  PRO F  64 -1  O  CYS F  61   N  VAL F  27
SHEET    4 AA6 8 VAL F  35  LEU F  38  1  N  PHE F  37   O  ILE F  62
SHEET    5 AA6 8 VAL F 100  HIS F 105  1  O  VAL F 101   N  LEU F  36
SHEET    6 AA6 8 VAL F 123  MET F 129  1  O  ALA F 127   N  LEU F 102
SHEET    7 AA6 8 LYS F 236  PRO F 243  1  O  LEU F 237   N  PHE F 128
SHEET    8 AA6 8 LEU F 262  GLY F 270  1  O  ILE F 267   N  TRP F 240
CISPEP   1 ASN A   41    PRO A   42          0        -3.51
CISPEP   2 GLU A  214    PRO A  215          0        -2.06
CISPEP   3 THR A  242    PRO A  243          0         7.09
CISPEP   4 ASN B   41    PRO B   42          0        -7.39
CISPEP   5 GLU B  214    PRO B  215          0        -5.02
CISPEP   6 THR B  242    PRO B  243          0         4.26
CISPEP   7 ASN C   41    PRO C   42          0        -4.44
CISPEP   8 GLU C  214    PRO C  215          0        -7.95
CISPEP   9 THR C  242    PRO C  243          0         1.38
CISPEP  10 ASN D   41    PRO D   42          0        -3.35
CISPEP  11 GLU D  214    PRO D  215          0        -0.82
CISPEP  12 THR D  242    PRO D  243          0         2.41
CISPEP  13 ASN E   41    PRO E   42          0        -6.59
CISPEP  14 GLU E  214    PRO E  215          0        -1.41
CISPEP  15 THR E  242    PRO E  243          0         1.59
CISPEP  16 ASN F   41    PRO F   42          0        -6.24
CISPEP  17 GLU F  214    PRO F  215          0        -3.18
CISPEP  18 THR F  242    PRO F  243          0         6.02
CRYST1   67.350  143.144  106.676  90.00 108.38  90.00 P 1 21 1     12
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.014848  0.000000  0.004933        0.00000
SCALE2      0.000000  0.006986  0.000000        0.00000
SCALE3      0.000000  0.000000  0.009878        0.00000
TER    2461      HIS A 295
TER    4844      PRO B 291
TER    7261      HIS C 294
TER    9676      HIS D 294
TER   12063      PRO E 291
TER   14463      LEU F 293
MASTER      457    0   29  106   48    0    0    616337    6  154  138
END