longtext: 8qd3-pdb

content
HEADER    LYASE                                   28-AUG-23   8QD3
TITLE     AYG1P IN COMPLEX WITH 1,3,6,8-TETRAHYDROXYNAPHTHALENE
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: PIGMENT BIOSYNTHESIS PROTEIN YELLOWISH-GREEN 1;
COMPND   3 CHAIN: A, B, C, D;
COMPND   4 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: ASPERGILLUS FUMIGATUS;
SOURCE   3 ORGANISM_TAXID: 746128;
SOURCE   4 GENE: AYG1;
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3);
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 469008;
SOURCE   7 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;
SOURCE   8 EXPRESSION_SYSTEM_PLASMID: PRSET A
KEYWDS    NATURAL PRODUCT BIOSYNTHESIS, POLYKETIDE SYNTHASE SYSTEM, ALPHA,
KEYWDS   2 BETA-HYDROLASE FOLD, POLYKETIDE SHORTENING, RETRO CLAISEN REACTION,
KEYWDS   3 LYASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    M.SCHMALHOFER,A.L.VAGSTAD,Q.ZHOU,H.B.BODE,M.GROLL
REVDAT   1   13-MAR-24 8QD3    0
JRNL        AUTH   M.SCHMALHOFER,A.L.VAGSTAD,Q.ZHOU,H.B.BODE,M.GROLL
JRNL        TITL   POLYKETIDE TRIMMING SHAPES DIHYDROXYNAPHTHALENE-MELANIN AND
JRNL        TITL 2 ANTHRAQUINONE PIGMENTS
JRNL        REF    ADV SCI                                    2024
JRNL        REFN                   ESSN 2198-3844
JRNL        DOI    10.1002/ADVS.202400184
REMARK   2
REMARK   2 RESOLUTION.    1.70 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.8.0267
REMARK   3   AUTHORS     : MURSHUDOV,SKUBAK,LEBEDEV,PANNU,STEINER,
REMARK   3               : NICHOLLS,WINN,LONG,VAGIN
REMARK   3
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.70
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 46.48
REMARK   3   DATA CUTOFF            (SIGMA(F)) : NULL
REMARK   3   COMPLETENESS FOR RANGE        (%) : 93.9
REMARK   3   NUMBER OF REFLECTIONS             : 164908
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.198
REMARK   3   R VALUE            (WORKING SET) : 0.196
REMARK   3   FREE R VALUE                     : 0.221
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.100
REMARK   3   FREE R VALUE TEST SET COUNT      : 8775
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : NULL
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 1.70
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 1.74
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 11047
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 85.87
REMARK   3   BIN R VALUE           (WORKING SET) : 0.1980
REMARK   3   BIN FREE R VALUE SET COUNT          : 611
REMARK   3   BIN FREE R VALUE                    : 0.2640
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 12386
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 204
REMARK   3   SOLVENT ATOMS            : 1027
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 20.79
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : -22.38000
REMARK   3    B22 (A**2) : 37.13000
REMARK   3    B33 (A**2) : -14.74000
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : 10.63000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): 0.042
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.024
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.053
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 3.265
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.957
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.950
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A): 13091 ; 0.002 ; 0.013
REMARK   3   BOND LENGTHS OTHERS               (A): 11824 ; 0.001 ; 0.015
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES): 17927 ; 1.194 ; 1.642
REMARK   3   BOND ANGLES OTHERS          (DEGREES): 27239 ; 1.132 ; 1.574
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):  1624 ; 6.222 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   658 ;32.132 ;21.641
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):  1919 ;12.529 ;15.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):    77 ;12.302 ;15.000
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):  1666 ; 0.049 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A): 15002 ; 0.003 ; 0.020
REMARK   3   GENERAL PLANES OTHERS             (A):  3024 ; 0.001 ; 0.020
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  6415 ; 1.032 ; 2.169
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  6414 ; 1.032 ; 2.168
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  8027 ; 1.392 ; 3.257
REMARK   3   MAIN-CHAIN ANGLE OTHER ATOMS   (A**2):  8028 ; 1.392 ; 3.257
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  6676 ; 0.928 ; 2.256
REMARK   3   SIDE-CHAIN BOND OTHER ATOMS    (A**2):  6677 ; 0.927 ; 2.256
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN ANGLE OTHER ATOMS   (A**2):  9888 ; 1.213 ; 3.352
REMARK   3   LONG RANGE B REFINED ATOMS     (A**2): 15447 ; 2.269 ;25.974
REMARK   3   LONG RANGE B OTHER ATOMS       (A**2): 15448 ; 2.269 ;25.974
REMARK   3
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2): 24913 ; 0.474 ; 3.000
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : MASK
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.20
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE RIDING
REMARK   3  POSITIONS
REMARK   4
REMARK   4 8QD3 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 30-AUG-23.
REMARK 100 THE DEPOSITION ID IS D_1292132996.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 27-NOV-21
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : NULL
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : SLS
REMARK 200  BEAMLINE                       : X06SA
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.0
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : PIXEL
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS EIGER X 16M
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200  DATA SCALING SOFTWARE          : XSCALE
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 173708
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.700
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 94.6
REMARK 200  DATA REDUNDANCY                : 3.200
REMARK 200  R MERGE                    (I) : 0.09400
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 6.7000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.70
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.80
REMARK 200  COMPLETENESS FOR SHELL     (%) : 95.7
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL
REMARK 200  R MERGE FOR SHELL          (I) : 0.60000
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 1.900
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: REFMAC
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 45.18
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.24
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 100 MM K/NA TARTRATE, 25.5% PEG 3350,
REMARK 280  VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 293K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000       53.72000
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2, 3, 4
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 3
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 4
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: D
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A   -16
REMARK 465     ARG A   -15
REMARK 465     GLY A   -14
REMARK 465     SER A   -13
REMARK 465     HIS A   -12
REMARK 465     HIS A   -11
REMARK 465     HIS A   -10
REMARK 465     HIS A    -9
REMARK 465     HIS A    -8
REMARK 465     HIS A    -7
REMARK 465     GLU A    -6
REMARK 465     ASN A    -5
REMARK 465     LEU A    -4
REMARK 465     TYR A    -3
REMARK 465     PHE A    -2
REMARK 465     GLN A    -1
REMARK 465     GLY A     0
REMARK 465     SER A     1
REMARK 465     PRO A     2
REMARK 465     PRO A   401
REMARK 465     SER A   402
REMARK 465     LYS A   403
REMARK 465     THR A   404
REMARK 465     LYS A   405
REMARK 465     ASN A   406
REMARK 465     MET B   -16
REMARK 465     ARG B   -15
REMARK 465     GLY B   -14
REMARK 465     SER B   -13
REMARK 465     HIS B   -12
REMARK 465     HIS B   -11
REMARK 465     HIS B   -10
REMARK 465     HIS B    -9
REMARK 465     HIS B    -8
REMARK 465     HIS B    -7
REMARK 465     GLU B    -6
REMARK 465     ASN B    -5
REMARK 465     LEU B    -4
REMARK 465     TYR B    -3
REMARK 465     PHE B    -2
REMARK 465     GLN B    -1
REMARK 465     GLY B     0
REMARK 465     SER B     1
REMARK 465     PRO B     2
REMARK 465     PRO B   401
REMARK 465     SER B   402
REMARK 465     LYS B   403
REMARK 465     THR B   404
REMARK 465     LYS B   405
REMARK 465     ASN B   406
REMARK 465     MET C   -16
REMARK 465     ARG C   -15
REMARK 465     GLY C   -14
REMARK 465     SER C   -13
REMARK 465     HIS C   -12
REMARK 465     HIS C   -11
REMARK 465     HIS C   -10
REMARK 465     HIS C    -9
REMARK 465     HIS C    -8
REMARK 465     HIS C    -7
REMARK 465     GLU C    -6
REMARK 465     ASN C    -5
REMARK 465     LEU C    -4
REMARK 465     TYR C    -3
REMARK 465     PHE C    -2
REMARK 465     GLN C    -1
REMARK 465     GLY C     0
REMARK 465     SER C     1
REMARK 465     PRO C     2
REMARK 465     PRO C   401
REMARK 465     SER C   402
REMARK 465     LYS C   403
REMARK 465     THR C   404
REMARK 465     LYS C   405
REMARK 465     ASN C   406
REMARK 465     MET D   -16
REMARK 465     ARG D   -15
REMARK 465     GLY D   -14
REMARK 465     SER D   -13
REMARK 465     HIS D   -12
REMARK 465     HIS D   -11
REMARK 465     HIS D   -10
REMARK 465     HIS D    -9
REMARK 465     HIS D    -8
REMARK 465     HIS D    -7
REMARK 465     GLU D    -6
REMARK 465     ASN D    -5
REMARK 465     LEU D    -4
REMARK 465     TYR D    -3
REMARK 465     PHE D    -2
REMARK 465     GLN D    -1
REMARK 465     GLY D     0
REMARK 465     SER D     1
REMARK 465     PRO D     2
REMARK 465     PRO D   401
REMARK 465     SER D   402
REMARK 465     LYS D   403
REMARK 465     THR D   404
REMARK 465     LYS D   405
REMARK 465     ASN D   406
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     ARG A   3    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ASP A   8    CG   OD1  OD2
REMARK 470     LYS A  57    CG   CD   CE   NZ
REMARK 470     GLN A  87    CG   CD   OE1  NE2
REMARK 470     GLU A  92    CG   CD   OE1  OE2
REMARK 470     GLN A 242    CG   CD   OE1  NE2
REMARK 470     GLU A 291    CG   CD   OE1  OE2
REMARK 470     SER A 400    OG
REMARK 470     ARG B   3    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ASP B   8    CG   OD1  OD2
REMARK 470     LEU B  86    CG   CD1  CD2
REMARK 470     GLN B  87    CG   CD   OE1  NE2
REMARK 470     GLU B  92    CG   CD   OE1  OE2
REMARK 470     LYS B 135    CG   CD   CE   NZ
REMARK 470     LEU B 139    CG   CD1  CD2
REMARK 470     GLN B 242    CG   CD   OE1  NE2
REMARK 470     GLU B 291    CG   CD   OE1  OE2
REMARK 470     LYS B 316    CG   CD   CE   NZ
REMARK 470     GLU B 320    CG   CD   OE1  OE2
REMARK 470     ARG C   3    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ASP C   8    CG   OD1  OD2
REMARK 470     LYS C  57    CG   CD   CE   NZ
REMARK 470     ASN C  58    CG   OD1  ND2
REMARK 470     GLN C  87    CG   CD   OE1  NE2
REMARK 470     HIS C  91    CG   ND1  CD2  CE1  NE2
REMARK 470     GLU C  92    CG   CD   OE1  OE2
REMARK 470     GLU C  93    CG   CD   OE1  OE2
REMARK 470     GLN C 131    CG   CD   OE1  NE2
REMARK 470     LEU C 139    CG   CD1  CD2
REMARK 470     ARG C 145    CG   CD   NE   CZ   NH1  NH2
REMARK 470     GLN C 174    CG   CD   OE1  NE2
REMARK 470     ASN C 176    CG   OD1  ND2
REMARK 470     GLN C 242    CG   CD   OE1  NE2
REMARK 470     LYS C 316    CG   CD   CE   NZ
REMARK 470     LYS C 327    CG   CD   CE   NZ
REMARK 470     SER C 400    OG
REMARK 470     ARG D   3    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ASP D   8    CG   OD1  OD2
REMARK 470     LYS D  34    CG   CD   CE   NZ
REMARK 470     LYS D  57    CG   CD   CE   NZ
REMARK 470     GLN D  87    CG   CD   OE1  NE2
REMARK 470     HIS D  91    CG   ND1  CD2  CE1  NE2
REMARK 470     GLN D 174    CG   CD   OE1  NE2
REMARK 470     GLU D 291    CG   CD   OE1  OE2
REMARK 470     LYS D 316    CG   CD   CE   NZ
REMARK 470     GLU D 319    CG   CD   OE1  OE2
REMARK 470     LYS D 327    CG   CD   CE   NZ
REMARK 470     SER D 400    OG
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    ARG A  27      -65.17   -131.61
REMARK 500    ASP A  41      -10.33     78.96
REMARK 500    TYR A 190     -168.73   -114.34
REMARK 500    ASN A 194       25.04   -141.90
REMARK 500    ALA A 217     -120.17     47.31
REMARK 500    SER A 257     -107.12     57.64
REMARK 500    CYS A 284      -10.05   -152.50
REMARK 500    HIS A 285      -73.52   -160.44
REMARK 500    HIS A 299     -152.82   -106.62
REMARK 500    ASP A 338       52.29    -93.56
REMARK 500    ASP A 351       34.96    -93.30
REMARK 500    MET A 381      -30.57     87.14
REMARK 500    ARG B  27      -65.24   -122.29
REMARK 500    ARG B  27      -66.67   -121.31
REMARK 500    ASP B  41       -1.97     80.35
REMARK 500    LYS B  90       77.87   -109.44
REMARK 500    TYR B 190     -168.15   -115.14
REMARK 500    ALA B 217     -118.63     45.99
REMARK 500    SER B 257     -112.62     57.36
REMARK 500    CYS B 284      -13.17   -152.55
REMARK 500    HIS B 285      -68.91   -157.76
REMARK 500    HIS B 299     -148.82   -112.63
REMARK 500    ASP B 338       50.60    -91.36
REMARK 500    ASP B 351       37.31    -94.50
REMARK 500    PRO B 379     -166.54    -78.85
REMARK 500    MET B 381      -22.43     88.68
REMARK 500    ARG C  27      -68.12   -141.53
REMARK 500    ASP C  41       -2.01     84.27
REMARK 500    THR C 185     -169.68    -79.65
REMARK 500    ASN C 194       27.12   -141.27
REMARK 500    ALA C 217     -119.18     44.78
REMARK 500    SER C 257     -106.86     59.48
REMARK 500    CYS C 284       -4.66   -155.62
REMARK 500    HIS C 285      -70.67   -162.22
REMARK 500    HIS C 299     -150.37   -108.00
REMARK 500    ASP C 351       40.40    -97.27
REMARK 500    HIS C 380      126.77    -36.72
REMARK 500    MET C 381      -22.96     84.23
REMARK 500    ASP D  11       36.89    -91.71
REMARK 500    ARG D  27      -66.96   -128.92
REMARK 500    ARG D  27      -66.57   -130.60
REMARK 500    ASP D  41       -7.64     86.40
REMARK 500    TYR D 190     -168.08   -116.45
REMARK 500    ASN D 194       32.02   -140.38
REMARK 500    ALA D 217     -124.16     48.06
REMARK 500    SER D 257     -112.86     55.75
REMARK 500    CYS D 284      -14.30   -152.12
REMARK 500    HIS D 285      -70.75   -159.69
REMARK 500    HIS D 299     -152.80   -105.75
REMARK 500    ASP D 338       54.70    -90.36
REMARK 500
REMARK 500 THIS ENTRY HAS      52 RAMACHANDRAN OUTLIERS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 6HXA   RELATED DB: PDB
REMARK 900 ANTI FROM P. LUMINESCENS CATALYSES TERMINAL POLYKETIDE SHORTENING
REMARK 900 IN THE BIOSYNTHESIS OF ANTHRAQUINONES
DBREF  8QD3 A    2   406  UNP    Q9UVV1   Q9UVV1_ASPFM     2    406
DBREF  8QD3 B    2   406  UNP    Q9UVV1   Q9UVV1_ASPFM     2    406
DBREF  8QD3 C    2   406  UNP    Q9UVV1   Q9UVV1_ASPFM     2    406
DBREF  8QD3 D    2   406  UNP    Q9UVV1   Q9UVV1_ASPFM     2    406
SEQADV 8QD3 MET A  -16  UNP  Q9UVV1              INITIATING METHIONINE
SEQADV 8QD3 ARG A  -15  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 GLY A  -14  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 SER A  -13  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 HIS A  -12  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 HIS A  -11  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 HIS A  -10  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 HIS A   -9  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 HIS A   -8  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 HIS A   -7  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 GLU A   -6  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 ASN A   -5  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 LEU A   -4  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 TYR A   -3  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 PHE A   -2  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 GLN A   -1  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 GLY A    0  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 SER A    1  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 MET B  -16  UNP  Q9UVV1              INITIATING METHIONINE
SEQADV 8QD3 ARG B  -15  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 GLY B  -14  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 SER B  -13  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 HIS B  -12  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 HIS B  -11  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 HIS B  -10  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 HIS B   -9  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 HIS B   -8  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 HIS B   -7  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 GLU B   -6  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 ASN B   -5  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 LEU B   -4  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 TYR B   -3  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 PHE B   -2  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 GLN B   -1  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 GLY B    0  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 SER B    1  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 MET C  -16  UNP  Q9UVV1              INITIATING METHIONINE
SEQADV 8QD3 ARG C  -15  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 GLY C  -14  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 SER C  -13  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 HIS C  -12  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 HIS C  -11  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 HIS C  -10  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 HIS C   -9  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 HIS C   -8  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 HIS C   -7  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 GLU C   -6  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 ASN C   -5  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 LEU C   -4  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 TYR C   -3  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 PHE C   -2  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 GLN C   -1  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 GLY C    0  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 SER C    1  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 MET D  -16  UNP  Q9UVV1              INITIATING METHIONINE
SEQADV 8QD3 ARG D  -15  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 GLY D  -14  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 SER D  -13  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 HIS D  -12  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 HIS D  -11  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 HIS D  -10  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 HIS D   -9  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 HIS D   -8  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 HIS D   -7  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 GLU D   -6  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 ASN D   -5  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 LEU D   -4  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 TYR D   -3  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 PHE D   -2  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 GLN D   -1  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 GLY D    0  UNP  Q9UVV1              EXPRESSION TAG
SEQADV 8QD3 SER D    1  UNP  Q9UVV1              EXPRESSION TAG
SEQRES   1 A  423  MET ARG GLY SER HIS HIS HIS HIS HIS HIS GLU ASN LEU
SEQRES   2 A  423  TYR PHE GLN GLY SER PRO ARG TRP ILE LEU GLY ASP LYS
SEQRES   3 A  423  PHE ASP THR VAL PHE PRO HIS LYS GLY SER LEU LYS VAL
SEQRES   4 A  423  LEU TRP GLU SER ARG TRP LYS PHE ALA CYS SER LYS SER
SEQRES   5 A  423  VAL TYR PRO PHE HIS ASP GLY SER ILE GLU ASP PHE GLU
SEQRES   6 A  423  PRO ILE PHE ASN HIS LEU ILE SER LYS ASN ILE ASN ASP
SEQRES   7 A  423  ALA ALA SER ASP GLU TYR THR GLN ALA PHE LEU PRO THR
SEQRES   8 A  423  ALA SER ALA LEU GLU GLU LYS ALA ALA GLN ALA LEU GLN
SEQRES   9 A  423  ALA GLY LYS HIS GLU GLU ALA SER ASN LEU LEU CYS ARG
SEQRES  10 A  423  ALA ALA VAL VAL TYR ARG ILE SER ARG PHE PRO TYR VAL
SEQRES  11 A  423  ASP ILE THR LYS PRO ASN SER ILE LYS ARG VAL ALA PHE
SEQRES  12 A  423  GLU ARG GLN LYS GLN ALA TYR LEU LYS ALA THR SER LEU
SEQRES  13 A  423  TRP THR GLN PRO ILE ARG GLU VAL THR VAL PRO HIS THR
SEQRES  14 A  423  TYR ARG THR GLY ASN ASP GLY ALA HIS ILE PRO ILE TYR
SEQRES  15 A  423  ILE ARG THR PRO ALA GLY ALA ASP GLN SER ASN PRO VAL
SEQRES  16 A  423  PRO ILE VAL LEU ILE MET THR GLY LEU ASP GLY TYR ARG
SEQRES  17 A  423  PRO ASP ASN SER GLN ARG THR HIS GLU ILE LEU ALA ARG
SEQRES  18 A  423  GLY TRP ALA ALA VAL VAL ALA GLU ILE PRO GLY THR ALA
SEQRES  19 A  423  ASP CYS PRO ALA ASP PRO ALA ASP PRO ALA SER PRO ASP
SEQRES  20 A  423  ARG LEU TRP ASP SER VAL LEU SER TYR LEU ASP GLN ARG
SEQRES  21 A  423  PRO GLU LEU ASN THR ALA LYS MET VAL VAL TRP GLY LEU
SEQRES  22 A  423  SER ALA GLY GLY TYR TYR ALA ILE ARG ALA ALA HIS THR
SEQRES  23 A  423  HIS ARG ASP ARG LEU LEU GLY ALA ILE ALA HIS GLY PRO
SEQRES  24 A  423  GLY CYS HIS TYR TYR LEU ASP PRO GLU TRP LEU ALA LYS
SEQRES  25 A  423  VAL ASN ASP HIS GLU TYR PRO PHE GLU ILE THR ALA ALA
SEQRES  26 A  423  TRP ALA THR LYS HIS GLY TYR LYS THR VAL GLU GLU PHE
SEQRES  27 A  423  VAL ALA GLY ALA GLN LYS LYS PHE SER LEU VAL GLU THR
SEQRES  28 A  423  GLY ILE VAL ASP GLN PRO SER CYS ARG LEU LEU LEU LEU
SEQRES  29 A  423  ASN GLY VAL ASP ASP GLY VAL VAL PRO ILE GLU ASP CYS
SEQRES  30 A  423  LEU VAL LEU PHE GLU HIS GLY SER PRO LYS GLU GLY ARG
SEQRES  31 A  423  PHE TYR LYS GLY LEU PRO HIS MET GLY TYR PRO ASN SER
SEQRES  32 A  423  LEU PRO VAL SER TYR GLU TRP LEU GLU GLN VAL LEU ALA
SEQRES  33 A  423  SER PRO SER LYS THR LYS ASN
SEQRES   1 B  423  MET ARG GLY SER HIS HIS HIS HIS HIS HIS GLU ASN LEU
SEQRES   2 B  423  TYR PHE GLN GLY SER PRO ARG TRP ILE LEU GLY ASP LYS
SEQRES   3 B  423  PHE ASP THR VAL PHE PRO HIS LYS GLY SER LEU LYS VAL
SEQRES   4 B  423  LEU TRP GLU SER ARG TRP LYS PHE ALA CYS SER LYS SER
SEQRES   5 B  423  VAL TYR PRO PHE HIS ASP GLY SER ILE GLU ASP PHE GLU
SEQRES   6 B  423  PRO ILE PHE ASN HIS LEU ILE SER LYS ASN ILE ASN ASP
SEQRES   7 B  423  ALA ALA SER ASP GLU TYR THR GLN ALA PHE LEU PRO THR
SEQRES   8 B  423  ALA SER ALA LEU GLU GLU LYS ALA ALA GLN ALA LEU GLN
SEQRES   9 B  423  ALA GLY LYS HIS GLU GLU ALA SER ASN LEU LEU CYS ARG
SEQRES  10 B  423  ALA ALA VAL VAL TYR ARG ILE SER ARG PHE PRO TYR VAL
SEQRES  11 B  423  ASP ILE THR LYS PRO ASN SER ILE LYS ARG VAL ALA PHE
SEQRES  12 B  423  GLU ARG GLN LYS GLN ALA TYR LEU LYS ALA THR SER LEU
SEQRES  13 B  423  TRP THR GLN PRO ILE ARG GLU VAL THR VAL PRO HIS THR
SEQRES  14 B  423  TYR ARG THR GLY ASN ASP GLY ALA HIS ILE PRO ILE TYR
SEQRES  15 B  423  ILE ARG THR PRO ALA GLY ALA ASP GLN SER ASN PRO VAL
SEQRES  16 B  423  PRO ILE VAL LEU ILE MET THR GLY LEU ASP GLY TYR ARG
SEQRES  17 B  423  PRO ASP ASN SER GLN ARG THR HIS GLU ILE LEU ALA ARG
SEQRES  18 B  423  GLY TRP ALA ALA VAL VAL ALA GLU ILE PRO GLY THR ALA
SEQRES  19 B  423  ASP CYS PRO ALA ASP PRO ALA ASP PRO ALA SER PRO ASP
SEQRES  20 B  423  ARG LEU TRP ASP SER VAL LEU SER TYR LEU ASP GLN ARG
SEQRES  21 B  423  PRO GLU LEU ASN THR ALA LYS MET VAL VAL TRP GLY LEU
SEQRES  22 B  423  SER ALA GLY GLY TYR TYR ALA ILE ARG ALA ALA HIS THR
SEQRES  23 B  423  HIS ARG ASP ARG LEU LEU GLY ALA ILE ALA HIS GLY PRO
SEQRES  24 B  423  GLY CYS HIS TYR TYR LEU ASP PRO GLU TRP LEU ALA LYS
SEQRES  25 B  423  VAL ASN ASP HIS GLU TYR PRO PHE GLU ILE THR ALA ALA
SEQRES  26 B  423  TRP ALA THR LYS HIS GLY TYR LYS THR VAL GLU GLU PHE
SEQRES  27 B  423  VAL ALA GLY ALA GLN LYS LYS PHE SER LEU VAL GLU THR
SEQRES  28 B  423  GLY ILE VAL ASP GLN PRO SER CYS ARG LEU LEU LEU LEU
SEQRES  29 B  423  ASN GLY VAL ASP ASP GLY VAL VAL PRO ILE GLU ASP CYS
SEQRES  30 B  423  LEU VAL LEU PHE GLU HIS GLY SER PRO LYS GLU GLY ARG
SEQRES  31 B  423  PHE TYR LYS GLY LEU PRO HIS MET GLY TYR PRO ASN SER
SEQRES  32 B  423  LEU PRO VAL SER TYR GLU TRP LEU GLU GLN VAL LEU ALA
SEQRES  33 B  423  SER PRO SER LYS THR LYS ASN
SEQRES   1 C  423  MET ARG GLY SER HIS HIS HIS HIS HIS HIS GLU ASN LEU
SEQRES   2 C  423  TYR PHE GLN GLY SER PRO ARG TRP ILE LEU GLY ASP LYS
SEQRES   3 C  423  PHE ASP THR VAL PHE PRO HIS LYS GLY SER LEU LYS VAL
SEQRES   4 C  423  LEU TRP GLU SER ARG TRP LYS PHE ALA CYS SER LYS SER
SEQRES   5 C  423  VAL TYR PRO PHE HIS ASP GLY SER ILE GLU ASP PHE GLU
SEQRES   6 C  423  PRO ILE PHE ASN HIS LEU ILE SER LYS ASN ILE ASN ASP
SEQRES   7 C  423  ALA ALA SER ASP GLU TYR THR GLN ALA PHE LEU PRO THR
SEQRES   8 C  423  ALA SER ALA LEU GLU GLU LYS ALA ALA GLN ALA LEU GLN
SEQRES   9 C  423  ALA GLY LYS HIS GLU GLU ALA SER ASN LEU LEU CYS ARG
SEQRES  10 C  423  ALA ALA VAL VAL TYR ARG ILE SER ARG PHE PRO TYR VAL
SEQRES  11 C  423  ASP ILE THR LYS PRO ASN SER ILE LYS ARG VAL ALA PHE
SEQRES  12 C  423  GLU ARG GLN LYS GLN ALA TYR LEU LYS ALA THR SER LEU
SEQRES  13 C  423  TRP THR GLN PRO ILE ARG GLU VAL THR VAL PRO HIS THR
SEQRES  14 C  423  TYR ARG THR GLY ASN ASP GLY ALA HIS ILE PRO ILE TYR
SEQRES  15 C  423  ILE ARG THR PRO ALA GLY ALA ASP GLN SER ASN PRO VAL
SEQRES  16 C  423  PRO ILE VAL LEU ILE MET THR GLY LEU ASP GLY TYR ARG
SEQRES  17 C  423  PRO ASP ASN SER GLN ARG THR HIS GLU ILE LEU ALA ARG
SEQRES  18 C  423  GLY TRP ALA ALA VAL VAL ALA GLU ILE PRO GLY THR ALA
SEQRES  19 C  423  ASP CYS PRO ALA ASP PRO ALA ASP PRO ALA SER PRO ASP
SEQRES  20 C  423  ARG LEU TRP ASP SER VAL LEU SER TYR LEU ASP GLN ARG
SEQRES  21 C  423  PRO GLU LEU ASN THR ALA LYS MET VAL VAL TRP GLY LEU
SEQRES  22 C  423  SER ALA GLY GLY TYR TYR ALA ILE ARG ALA ALA HIS THR
SEQRES  23 C  423  HIS ARG ASP ARG LEU LEU GLY ALA ILE ALA HIS GLY PRO
SEQRES  24 C  423  GLY CYS HIS TYR TYR LEU ASP PRO GLU TRP LEU ALA LYS
SEQRES  25 C  423  VAL ASN ASP HIS GLU TYR PRO PHE GLU ILE THR ALA ALA
SEQRES  26 C  423  TRP ALA THR LYS HIS GLY TYR LYS THR VAL GLU GLU PHE
SEQRES  27 C  423  VAL ALA GLY ALA GLN LYS LYS PHE SER LEU VAL GLU THR
SEQRES  28 C  423  GLY ILE VAL ASP GLN PRO SER CYS ARG LEU LEU LEU LEU
SEQRES  29 C  423  ASN GLY VAL ASP ASP GLY VAL VAL PRO ILE GLU ASP CYS
SEQRES  30 C  423  LEU VAL LEU PHE GLU HIS GLY SER PRO LYS GLU GLY ARG
SEQRES  31 C  423  PHE TYR LYS GLY LEU PRO HIS MET GLY TYR PRO ASN SER
SEQRES  32 C  423  LEU PRO VAL SER TYR GLU TRP LEU GLU GLN VAL LEU ALA
SEQRES  33 C  423  SER PRO SER LYS THR LYS ASN
SEQRES   1 D  423  MET ARG GLY SER HIS HIS HIS HIS HIS HIS GLU ASN LEU
SEQRES   2 D  423  TYR PHE GLN GLY SER PRO ARG TRP ILE LEU GLY ASP LYS
SEQRES   3 D  423  PHE ASP THR VAL PHE PRO HIS LYS GLY SER LEU LYS VAL
SEQRES   4 D  423  LEU TRP GLU SER ARG TRP LYS PHE ALA CYS SER LYS SER
SEQRES   5 D  423  VAL TYR PRO PHE HIS ASP GLY SER ILE GLU ASP PHE GLU
SEQRES   6 D  423  PRO ILE PHE ASN HIS LEU ILE SER LYS ASN ILE ASN ASP
SEQRES   7 D  423  ALA ALA SER ASP GLU TYR THR GLN ALA PHE LEU PRO THR
SEQRES   8 D  423  ALA SER ALA LEU GLU GLU LYS ALA ALA GLN ALA LEU GLN
SEQRES   9 D  423  ALA GLY LYS HIS GLU GLU ALA SER ASN LEU LEU CYS ARG
SEQRES  10 D  423  ALA ALA VAL VAL TYR ARG ILE SER ARG PHE PRO TYR VAL
SEQRES  11 D  423  ASP ILE THR LYS PRO ASN SER ILE LYS ARG VAL ALA PHE
SEQRES  12 D  423  GLU ARG GLN LYS GLN ALA TYR LEU LYS ALA THR SER LEU
SEQRES  13 D  423  TRP THR GLN PRO ILE ARG GLU VAL THR VAL PRO HIS THR
SEQRES  14 D  423  TYR ARG THR GLY ASN ASP GLY ALA HIS ILE PRO ILE TYR
SEQRES  15 D  423  ILE ARG THR PRO ALA GLY ALA ASP GLN SER ASN PRO VAL
SEQRES  16 D  423  PRO ILE VAL LEU ILE MET THR GLY LEU ASP GLY TYR ARG
SEQRES  17 D  423  PRO ASP ASN SER GLN ARG THR HIS GLU ILE LEU ALA ARG
SEQRES  18 D  423  GLY TRP ALA ALA VAL VAL ALA GLU ILE PRO GLY THR ALA
SEQRES  19 D  423  ASP CYS PRO ALA ASP PRO ALA ASP PRO ALA SER PRO ASP
SEQRES  20 D  423  ARG LEU TRP ASP SER VAL LEU SER TYR LEU ASP GLN ARG
SEQRES  21 D  423  PRO GLU LEU ASN THR ALA LYS MET VAL VAL TRP GLY LEU
SEQRES  22 D  423  SER ALA GLY GLY TYR TYR ALA ILE ARG ALA ALA HIS THR
SEQRES  23 D  423  HIS ARG ASP ARG LEU LEU GLY ALA ILE ALA HIS GLY PRO
SEQRES  24 D  423  GLY CYS HIS TYR TYR LEU ASP PRO GLU TRP LEU ALA LYS
SEQRES  25 D  423  VAL ASN ASP HIS GLU TYR PRO PHE GLU ILE THR ALA ALA
SEQRES  26 D  423  TRP ALA THR LYS HIS GLY TYR LYS THR VAL GLU GLU PHE
SEQRES  27 D  423  VAL ALA GLY ALA GLN LYS LYS PHE SER LEU VAL GLU THR
SEQRES  28 D  423  GLY ILE VAL ASP GLN PRO SER CYS ARG LEU LEU LEU LEU
SEQRES  29 D  423  ASN GLY VAL ASP ASP GLY VAL VAL PRO ILE GLU ASP CYS
SEQRES  30 D  423  LEU VAL LEU PHE GLU HIS GLY SER PRO LYS GLU GLY ARG
SEQRES  31 D  423  PHE TYR LYS GLY LEU PRO HIS MET GLY TYR PRO ASN SER
SEQRES  32 D  423  LEU PRO VAL SER TYR GLU TRP LEU GLU GLN VAL LEU ALA
SEQRES  33 D  423  SER PRO SER LYS THR LYS ASN
HET    QW8  A1001      14
HET    PGE  A1002      10
HET    FLV  A1003      15
HET    FLV  A1004      15
HET    QW8  B1001      14
HET    EDO  B1002       4
HET    FLV  B1003      15
HET    FLV  B1004      15
HET    QW8  C1001      14
HET    PGE  C1002      10
HET    EDO  C1003       4
HET    FLV  C1004      15
HET    FLV  C1005      15
HET    QW8  D1001      14
HET    FLV  D1002      15
HET    FLV  D1003      15
HETNAM     QW8 NAPHTHALENE-1,3,6,8-TETROL
HETNAM     PGE TRIETHYLENE GLYCOL
HETNAM     FLV FLAVIOLIN
HETNAM     EDO 1,2-ETHANEDIOL
HETSYN     QW8 1,3,6,8-TETRAHYDROXYNAPHTHALENE
HETSYN     FLV 2,5,7-TRIHYDROXYNAPHTHOQUINONE
HETSYN     EDO ETHYLENE GLYCOL
FORMUL   5  QW8    4(C10 H8 O4)
FORMUL   6  PGE    2(C6 H14 O4)
FORMUL   7  FLV    8(C10 H6 O5)
FORMUL  10  EDO    2(C2 H6 O2)
FORMUL  21  HOH   *1027(H2 O)
HELIX    1 AA1 LEU A    6  THR A   12  5                                   7
HELIX    2 AA2 SER A   19  ARG A   27  1                                   9
HELIX    3 AA3 ARG A   27  LYS A   34  1                                   8
HELIX    4 AA4 SER A   43  LYS A   57  1                                  15
HELIX    5 AA5 SER A   64  GLN A   69  1                                   6
HELIX    6 AA6 PHE A   71  ALA A   88  1                                  18
HELIX    7 AA7 LYS A   90  ARG A  109  1                                  20
HELIX    8 AA8 SER A  120  SER A  138  1                                  19
HELIX    9 AA9 ASN A  194  ARG A  204  1                                  11
HELIX   10 AB1 ALA A  227  ARG A  243  1                                  17
HELIX   11 AB2 ALA A  258  HIS A  270  1                                  13
HELIX   12 AB3 ARG A  271  LEU A  274  5                                   4
HELIX   13 AB4 HIS A  285  LEU A  288  5                                   4
HELIX   14 AB5 ASP A  289  ALA A  294  1                                   6
HELIX   15 AB6 LYS A  295  HIS A  299  5                                   5
HELIX   16 AB7 ILE A  305  HIS A  313  1                                   9
HELIX   17 AB8 THR A  317  SER A  330  1                                  14
HELIX   18 AB9 ILE A  357  VAL A  362  1                                   6
HELIX   19 AC1 LEU A  363  HIS A  366  5                                   4
HELIX   20 AC2 ASN A  385  LEU A  398  1                                  14
HELIX   21 AC3 LEU B    6  THR B   12  5                                   7
HELIX   22 AC4 SER B   19  ARG B   27  1                                   9
HELIX   23 AC5 ARG B   27  SER B   35  1                                   9
HELIX   24 AC6 SER B   43  LYS B   57  1                                  15
HELIX   25 AC7 SER B   64  ALA B   70  1                                   7
HELIX   26 AC8 PHE B   71  ALA B   88  1                                  18
HELIX   27 AC9 LYS B   90  ARG B  109  1                                  20
HELIX   28 AD1 SER B  120  SER B  138  1                                  19
HELIX   29 AD2 ASN B  194  ARG B  204  1                                  11
HELIX   30 AD3 ALA B  227  ARG B  243  1                                  17
HELIX   31 AD4 ALA B  258  HIS B  270  1                                  13
HELIX   32 AD5 ARG B  271  LEU B  274  5                                   4
HELIX   33 AD6 HIS B  285  LEU B  288  5                                   4
HELIX   34 AD7 ASP B  289  ALA B  294  1                                   6
HELIX   35 AD8 LYS B  295  HIS B  299  5                                   5
HELIX   36 AD9 ILE B  305  HIS B  313  1                                   9
HELIX   37 AE1 THR B  317  SER B  330  1                                  14
HELIX   38 AE2 ILE B  357  VAL B  362  1                                   6
HELIX   39 AE3 LEU B  363  HIS B  366  5                                   4
HELIX   40 AE4 ASN B  385  LEU B  398  1                                  14
HELIX   41 AE5 LEU C    6  THR C   12  5                                   7
HELIX   42 AE6 SER C   19  ARG C   27  1                                   9
HELIX   43 AE7 ARG C   27  LYS C   34  1                                   8
HELIX   44 AE8 SER C   43  ASN C   58  1                                  16
HELIX   45 AE9 SER C   64  GLN C   69  1                                   6
HELIX   46 AF1 PHE C   71  ALA C   88  1                                  18
HELIX   47 AF2 LYS C   90  ARG C  109  1                                  20
HELIX   48 AF3 SER C  120  SER C  138  1                                  19
HELIX   49 AF4 TYR C  190  ASP C  193  5                                   4
HELIX   50 AF5 ASN C  194  ARG C  204  1                                  11
HELIX   51 AF6 ALA C  227  ARG C  243  1                                  17
HELIX   52 AF7 ALA C  258  HIS C  270  1                                  13
HELIX   53 AF8 ARG C  271  LEU C  274  5                                   4
HELIX   54 AF9 HIS C  285  LEU C  288  5                                   4
HELIX   55 AG1 ASP C  289  VAL C  296  1                                   8
HELIX   56 AG2 ASN C  297  HIS C  299  5                                   3
HELIX   57 AG3 ILE C  305  HIS C  313  1                                   9
HELIX   58 AG4 THR C  317  SER C  330  1                                  14
HELIX   59 AG5 GLY C  335  GLN C  339  5                                   5
HELIX   60 AG6 ILE C  357  VAL C  362  1                                   6
HELIX   61 AG7 LEU C  363  HIS C  366  5                                   4
HELIX   62 AG8 LEU C  387  LEU C  398  1                                  12
HELIX   63 AG9 LEU D    6  THR D   12  5                                   7
HELIX   64 AH1 SER D   19  ARG D   27  1                                   9
HELIX   65 AH2 ARG D   27  LYS D   34  1                                   8
HELIX   66 AH3 SER D   43  LYS D   57  1                                  15
HELIX   67 AH4 SER D   64  ALA D   70  1                                   7
HELIX   68 AH5 PHE D   71  ALA D   88  1                                  18
HELIX   69 AH6 LYS D   90  ARG D  109  1                                  20
HELIX   70 AH7 SER D  120  LEU D  139  1                                  20
HELIX   71 AH8 ASN D  194  ARG D  204  1                                  11
HELIX   72 AH9 ALA D  227  ARG D  243  1                                  17
HELIX   73 AI1 GLY D  259  HIS D  270  1                                  12
HELIX   74 AI2 ARG D  271  LEU D  274  5                                   4
HELIX   75 AI3 HIS D  285  LEU D  288  5                                   4
HELIX   76 AI4 ASP D  289  ALA D  294  1                                   6
HELIX   77 AI5 LYS D  295  HIS D  299  5                                   5
HELIX   78 AI6 ILE D  305  HIS D  313  1                                   9
HELIX   79 AI7 THR D  317  SER D  330  1                                  14
HELIX   80 AI8 ILE D  357  VAL D  362  1                                   6
HELIX   81 AI9 LEU D  363  HIS D  366  5                                   4
HELIX   82 AJ1 ASN D  385  LEU D  398  1                                  14
SHEET    1 AA116 ARG A 145  PRO A 150  0
SHEET    2 AA116 HIS A 161  ARG A 167 -1  O  ILE A 166   N  ARG A 145
SHEET    3 AA116 ALA A 207  ALA A 211 -1  O  ALA A 208   N  ARG A 167
SHEET    4 AA116 VAL A 178  MET A 184  1  N  ILE A 183   O  VAL A 209
SHEET    5 AA116 LEU A 246  LEU A 256  1  O  LEU A 256   N  MET A 184
SHEET    6 AA116 GLY A 276  HIS A 280  1  O  ILE A 278   N  GLY A 255
SHEET    7 AA116 ARG A 343  GLY A 349  1  O  LEU A 345   N  ALA A 279
SHEET    8 AA116 LYS A 370  TYR A 375  1  O  GLU A 371   N  LEU A 344
SHEET    9 AA116 LYS B 370  TYR B 375 -1  O  LYS B 370   N  GLY A 372
SHEET   10 AA116 ARG B 343  GLY B 349  1  N  LEU B 344   O  GLU B 371
SHEET   11 AA116 GLY B 276  HIS B 280  1  N  ALA B 279   O  LEU B 345
SHEET   12 AA116 LEU B 246  LEU B 256  1  N  GLY B 255   O  HIS B 280
SHEET   13 AA116 VAL B 178  MET B 184  1  N  VAL B 178   O  ASN B 247
SHEET   14 AA116 ALA B 207  ALA B 211  1  O  VAL B 209   N  ILE B 183
SHEET   15 AA116 HIS B 161  ARG B 167 -1  N  ARG B 167   O  ALA B 208
SHEET   16 AA116 ARG B 145  PRO B 150 -1  N  ARG B 145   O  ILE B 166
SHEET    1 AA2 8 ARG C 145  PRO C 150  0
SHEET    2 AA2 8 HIS C 161  ARG C 167 -1  O  ILE C 164   N  VAL C 147
SHEET    3 AA2 8 ALA C 207  ALA C 211 -1  O  ALA C 208   N  ARG C 167
SHEET    4 AA2 8 VAL C 178  MET C 184  1  N  ILE C 183   O  VAL C 209
SHEET    5 AA2 8 LEU C 246  LEU C 256  1  O  ASN C 247   N  VAL C 178
SHEET    6 AA2 8 GLY C 276  HIS C 280  1  O  ILE C 278   N  GLY C 255
SHEET    7 AA2 8 ARG C 343  GLY C 349  1  O  LEU C 345   N  ALA C 277
SHEET    8 AA2 8 GLU C 371  TYR C 375  1  O  GLU C 371   N  LEU C 346
SHEET    1 AA3 8 ARG D 145  PRO D 150  0
SHEET    2 AA3 8 HIS D 161  ARG D 167 -1  O  ILE D 166   N  ARG D 145
SHEET    3 AA3 8 ALA D 207  ALA D 211 -1  O  VAL D 210   N  TYR D 165
SHEET    4 AA3 8 VAL D 178  MET D 184  1  N  ILE D 183   O  VAL D 209
SHEET    5 AA3 8 LEU D 246  LEU D 256  1  O  ASN D 247   N  VAL D 178
SHEET    6 AA3 8 GLY D 276  HIS D 280  1  O  ILE D 278   N  GLY D 255
SHEET    7 AA3 8 ARG D 343  GLY D 349  1  O  LEU D 345   N  ALA D 279
SHEET    8 AA3 8 GLU D 371  TYR D 375  1  O  GLU D 371   N  LEU D 344
CISPEP   1 TYR A   37    PRO A   38          0         1.17
CISPEP   2 PHE A  110    PRO A  111          0        -3.26
CISPEP   3 TYR A  383    PRO A  384          0        -5.36
CISPEP   4 TYR B   37    PRO B   38          0         0.59
CISPEP   5 PHE B  110    PRO B  111          0        -4.88
CISPEP   6 TYR B  383    PRO B  384          0        -2.31
CISPEP   7 TYR C   37    PRO C   38          0         1.23
CISPEP   8 PHE C  110    PRO C  111          0        -2.37
CISPEP   9 TYR C  383    PRO C  384          0        -8.03
CISPEP  10 TYR D   37    PRO D   38          0        -0.12
CISPEP  11 PHE D  110    PRO D  111          0        -2.52
CISPEP  12 TYR D  383    PRO D  384          0        -2.37
CRYST1   85.480  107.440   92.720  90.00  90.16  90.00 P 1 21 1      8
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.011699  0.000000  0.000032        0.00000
SCALE2      0.000000  0.009308  0.000000        0.00000
SCALE3      0.000000  0.000000  0.010785        0.00000
TER    3139      SER A 400
TER    6269      SER B 400
TER    9368      SER C 400
TER   12491      SER D 400
MASTER      482    0   16   82   32    0    0    613617    4  204  132
END