longtext: 8qmz-pdb

content
HEADER    HYDROLASE                               25-SEP-23   8QMZ
TITLE     SOLUBLE EPOXIDE HYDROLASE IN COMPLEX WITH RK4
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: BIFUNCTIONAL EPOXIDE HYDROLASE 2;
COMPND   3 CHAIN: A, B, C, D;
COMPND   4 EC: 3.3.2.10,3.1.3.76;
COMPND   5 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE   3 ORGANISM_COMMON: HUMAN;
SOURCE   4 ORGANISM_TAXID: 9606;
SOURCE   5 GENE: EPHX2;
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562
KEYWDS    COMPLEX, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC,
KEYWDS   2 HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    A.KUMAR,F.ZHU,J.M.H.EHRLER,F.LI,C.EMPEL,Y.XU,I.ATODIRESEI,
AUTHOR   2 R.M.KOENIGS,E.PROSCHAK,S.KNAPP,STRUCTURAL GENOMICS CONSORTIUM (SGC)
REVDAT   1   14-FEB-24 8QMZ    0
JRNL        AUTH   F.LI,W.F.ZHU,C.EMPEL,O.DATSENKO,A.KUMAR,Y.XU,J.H.M.EHRLER,
JRNL        AUTH 2 I.ATODIRESEI,S.KNAPP,P.K.MYKHAILIUK,E.PROSCHAK,R.M.KOENIGS
JRNL        TITL   PHOTOSENSITIZATION ENABLES PAUSON-KHAND-TYPE REACTIONS WITH
JRNL        TITL 2 NITRENES.
JRNL        REF    SCIENCE                       V. 383   498 2024
JRNL        REFN                   ESSN 1095-9203
JRNL        PMID   38301027
JRNL        DOI    10.1126/SCIENCE.ADM8095
REMARK   2
REMARK   2 RESOLUTION.    1.47 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.8.0419
REMARK   3   AUTHORS     : MURSHUDOV,SKUBAK,LEBEDEV,PANNU,STEINER,
REMARK   3               : NICHOLLS,WINN,LONG,VAGIN
REMARK   3
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.47
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 49.47
REMARK   3   DATA CUTOFF            (SIGMA(F)) : NULL
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.5
REMARK   3   NUMBER OF REFLECTIONS             : 221479
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.189
REMARK   3   R VALUE            (WORKING SET) : 0.188
REMARK   3   FREE R VALUE                     : 0.214
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.900
REMARK   3   FREE R VALUE TEST SET COUNT      : 11504
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : NULL
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 1.47
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 1.51
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 15363
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 94.11
REMARK   3   BIN R VALUE           (WORKING SET) : 0.3050
REMARK   3   BIN FREE R VALUE SET COUNT          : 780
REMARK   3   BIN FREE R VALUE                    : 0.3310
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 10206
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 184
REMARK   3   SOLVENT ATOMS            : 841
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 21.38
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : -1.14000
REMARK   3    B22 (A**2) : 0.69000
REMARK   3    B33 (A**2) : 0.45000
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : 0.00000
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): 0.072
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.073
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.055
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 1.509
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.970
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.962
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A): 11079 ; 0.011 ; 0.012
REMARK   3   BOND LENGTHS OTHERS               (A): 10116 ; 0.001 ; 0.016
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES): 15098 ; 1.787 ; 1.657
REMARK   3   BOND ANGLES OTHERS          (DEGREES): 23415 ; 0.630 ; 1.576
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):  1363 ; 6.709 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):    62 ; 6.632 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):  1800 ;15.687 ;10.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):  NULL ;  NULL ;  NULL
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):  1561 ; 0.111 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A): 13190 ; 0.010 ; 0.020
REMARK   3   GENERAL PLANES OTHERS             (A):  2594 ; 0.002 ; 0.020
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  5329 ; 2.044 ; 2.092
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  5329 ; 2.043 ; 2.092
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  6730 ; 2.874 ; 3.759
REMARK   3   MAIN-CHAIN ANGLE OTHER ATOMS   (A**2):  6731 ; 2.874 ; 3.760
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  5750 ; 3.210 ; 2.413
REMARK   3   SIDE-CHAIN BOND OTHER ATOMS    (A**2):  5751 ; 3.209 ; 2.413
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN ANGLE OTHER ATOMS   (A**2):  8368 ; 4.800 ; 4.305
REMARK   3   LONG RANGE B REFINED ATOMS     (A**2): 12691 ; 5.938 ;22.180
REMARK   3   LONG RANGE B OTHER ATOMS       (A**2): 12692 ; 5.938 ;22.180
REMARK   3
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : MASK
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.20
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE RIDING
REMARK   3  POSITIONS
REMARK   4
REMARK   4 8QMZ COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 26-SEP-23.
REMARK 100 THE DEPOSITION ID IS D_1292133499.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 09-SEP-23
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 7.0
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : SLS
REMARK 200  BEAMLINE                       : X06SA
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.0
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : PIXEL
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS EIGER X 16M
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200  DATA SCALING SOFTWARE          : AIMLESS
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 233100
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.470
REMARK 200  RESOLUTION RANGE LOW       (A) : 49.470
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.5
REMARK 200  DATA REDUNDANCY                : 6.700
REMARK 200  R MERGE                    (I) : 0.06200
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 13.8000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.47
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.49
REMARK 200  COMPLETENESS FOR SHELL     (%) : NULL
REMARK 200  DATA REDUNDANCY IN SHELL       : 6.90
REMARK 200  R MERGE FOR SHELL          (I) : 1.12500
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: MOLREP
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 39.79
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.04
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 20% PEG6000, 10% ETHYLENE GLYCOL, 0.1M
REMARK 280  HEPES PH 7.0, 0.1M CALCIUM CHLORIDE, VAPOR DIFFUSION, SITTING
REMARK 280  DROP, TEMPERATURE 293K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X+1/2,-Y,Z+1/2
REMARK 290       3555   -X,Y+1/2,-Z+1/2
REMARK 290       4555   X+1/2,-Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       40.14500
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       94.20800
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       45.32100
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       94.20800
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       40.14500
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       45.32100
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2, 3, 4
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 3
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 4
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: D
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A   198
REMARK 465     GLY A   199
REMARK 465     SER A   200
REMARK 465     SER A   201
REMARK 465     HIS A   202
REMARK 465     HIS A   203
REMARK 465     HIS A   204
REMARK 465     HIS A   205
REMARK 465     HIS A   206
REMARK 465     HIS A   207
REMARK 465     SER A   208
REMARK 465     SER A   209
REMARK 465     GLY A   210
REMARK 465     LEU A   211
REMARK 465     VAL A   212
REMARK 465     PRO A   213
REMARK 465     ARG A   214
REMARK 465     GLY A   215
REMARK 465     SER A   216
REMARK 465     HIS A   217
REMARK 465     MET A   218
REMARK 465     ALA A   219
REMARK 465     SER A   220
REMARK 465     MET A   221
REMARK 465     LEU A   222
REMARK 465     ASN A   223
REMARK 465     THR A   224
REMARK 465     PRO A   225
REMARK 465     ALA A   226
REMARK 465     PRO A   227
REMARK 465     ASN A   548
REMARK 465     PRO A   549
REMARK 465     PRO A   550
REMARK 465     VAL A   551
REMARK 465     VAL A   552
REMARK 465     SER A   553
REMARK 465     LYS A   554
REMARK 465     MET A   555
REMARK 465     LEU A   556
REMARK 465     LEU A   557
REMARK 465     GLU A   558
REMARK 465     HIS A   559
REMARK 465     HIS A   560
REMARK 465     HIS A   561
REMARK 465     HIS A   562
REMARK 465     HIS A   563
REMARK 465     HIS A   564
REMARK 465     MET B   198
REMARK 465     GLY B   199
REMARK 465     SER B   200
REMARK 465     SER B   201
REMARK 465     HIS B   202
REMARK 465     HIS B   203
REMARK 465     HIS B   204
REMARK 465     HIS B   205
REMARK 465     HIS B   206
REMARK 465     HIS B   207
REMARK 465     SER B   208
REMARK 465     SER B   209
REMARK 465     GLY B   210
REMARK 465     LEU B   211
REMARK 465     VAL B   212
REMARK 465     PRO B   213
REMARK 465     ARG B   214
REMARK 465     GLY B   215
REMARK 465     SER B   216
REMARK 465     HIS B   217
REMARK 465     MET B   218
REMARK 465     ALA B   219
REMARK 465     SER B   220
REMARK 465     MET B   221
REMARK 465     LEU B   222
REMARK 465     ASN B   223
REMARK 465     THR B   224
REMARK 465     PRO B   225
REMARK 465     ALA B   226
REMARK 465     PRO B   227
REMARK 465     ALA B   546
REMARK 465     ARG B   547
REMARK 465     ASN B   548
REMARK 465     PRO B   549
REMARK 465     PRO B   550
REMARK 465     VAL B   551
REMARK 465     VAL B   552
REMARK 465     SER B   553
REMARK 465     LYS B   554
REMARK 465     MET B   555
REMARK 465     LEU B   556
REMARK 465     LEU B   557
REMARK 465     GLU B   558
REMARK 465     HIS B   559
REMARK 465     HIS B   560
REMARK 465     HIS B   561
REMARK 465     HIS B   562
REMARK 465     HIS B   563
REMARK 465     HIS B   564
REMARK 465     MET C   198
REMARK 465     GLY C   199
REMARK 465     SER C   200
REMARK 465     SER C   201
REMARK 465     HIS C   202
REMARK 465     HIS C   203
REMARK 465     HIS C   204
REMARK 465     HIS C   205
REMARK 465     HIS C   206
REMARK 465     HIS C   207
REMARK 465     SER C   208
REMARK 465     SER C   209
REMARK 465     GLY C   210
REMARK 465     LEU C   211
REMARK 465     VAL C   212
REMARK 465     PRO C   213
REMARK 465     ARG C   214
REMARK 465     GLY C   215
REMARK 465     SER C   216
REMARK 465     HIS C   217
REMARK 465     MET C   218
REMARK 465     ALA C   219
REMARK 465     SER C   220
REMARK 465     MET C   221
REMARK 465     LEU C   222
REMARK 465     ASN C   223
REMARK 465     THR C   224
REMARK 465     PRO C   225
REMARK 465     ALA C   226
REMARK 465     PRO C   227
REMARK 465     ASN C   548
REMARK 465     PRO C   549
REMARK 465     PRO C   550
REMARK 465     VAL C   551
REMARK 465     VAL C   552
REMARK 465     SER C   553
REMARK 465     LYS C   554
REMARK 465     MET C   555
REMARK 465     LEU C   556
REMARK 465     LEU C   557
REMARK 465     GLU C   558
REMARK 465     HIS C   559
REMARK 465     HIS C   560
REMARK 465     HIS C   561
REMARK 465     HIS C   562
REMARK 465     HIS C   563
REMARK 465     HIS C   564
REMARK 465     MET D   198
REMARK 465     GLY D   199
REMARK 465     SER D   200
REMARK 465     SER D   201
REMARK 465     HIS D   202
REMARK 465     HIS D   203
REMARK 465     HIS D   204
REMARK 465     HIS D   205
REMARK 465     HIS D   206
REMARK 465     HIS D   207
REMARK 465     SER D   208
REMARK 465     SER D   209
REMARK 465     GLY D   210
REMARK 465     LEU D   211
REMARK 465     VAL D   212
REMARK 465     PRO D   213
REMARK 465     ARG D   214
REMARK 465     GLY D   215
REMARK 465     SER D   216
REMARK 465     HIS D   217
REMARK 465     MET D   218
REMARK 465     ALA D   219
REMARK 465     SER D   220
REMARK 465     MET D   221
REMARK 465     LEU D   222
REMARK 465     ASN D   223
REMARK 465     THR D   224
REMARK 465     PRO D   225
REMARK 465     ALA D   226
REMARK 465     PRO D   227
REMARK 465     ASN D   548
REMARK 465     PRO D   549
REMARK 465     PRO D   550
REMARK 465     VAL D   551
REMARK 465     VAL D   552
REMARK 465     SER D   553
REMARK 465     LYS D   554
REMARK 465     MET D   555
REMARK 465     LEU D   556
REMARK 465     LEU D   557
REMARK 465     GLU D   558
REMARK 465     HIS D   559
REMARK 465     HIS D   560
REMARK 465     HIS D   561
REMARK 465     HIS D   562
REMARK 465     HIS D   563
REMARK 465     HIS D   564
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     ARG A 247    CG   CD   NE   CZ   NH1  NH2
REMARK 470     GLN A 283    CG   CD   OE1  NE2
REMARK 470     LYS A 315    CG   CD   CE   NZ
REMARK 470     LYS A 376    CG   CD   CE   NZ
REMARK 470     HIS A 420    CG   ND1  CD2  CE1  NE2
REMARK 470     GLU A 424    CG   CD   OE1  OE2
REMARK 470     GLU A 434    CG   CD   OE1  OE2
REMARK 470     GLU A 470    CG   CD   OE1  OE2
REMARK 470     GLN B 283    CG   CD   OE1  NE2
REMARK 470     LYS B 376    CG   CD   CE   NZ
REMARK 470     ASN B 378    CG   OD1  ND2
REMARK 470     GLU B 424    CG   CD   OE1  OE2
REMARK 470     GLN C 283    CG   CD   OE1  NE2
REMARK 470     LYS C 376    CG   CD   CE   NZ
REMARK 470     ASN C 378    CG   OD1  ND2
REMARK 470     VAL C 380    CG1  CG2
REMARK 470     GLU C 424    CG   CD   OE1  OE2
REMARK 470     GLN D 283    CG   CD   OE1  NE2
REMARK 470     LYS D 315    CE   NZ
REMARK 470     LYS D 376    CG   CD   CE   NZ
REMARK 470     SER D 418    OG
REMARK 470     LYS D 421    CG   CD   CE   NZ
REMARK 470     GLU D 424    CG   CD   OE1  OE2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   OD2  ASP D   382     O    HOH D   701              1.96
REMARK 500   O1   EDO D   604     O    HOH D   702              1.98
REMARK 500   O    SER D   544     O    HOH D   703              2.10
REMARK 500   O1   EDO C   603     O    HOH C   701              2.14
REMARK 500   CB   LYS B   376     O    HOH B   899              2.16
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION
REMARK 500    GLU A 494   CD    GLU A 494   OE2     0.072
REMARK 500    LEU C 228   CA    LEU C 228   CB      0.633
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    ARG B 249   NE  -  CZ  -  NH1 ANGL. DEV. =  -3.7 DEGREES
REMARK 500    ARG B 249   NE  -  CZ  -  NH2 ANGL. DEV. =   3.6 DEGREES
REMARK 500    LEU C 228   CB  -  CA  -  C   ANGL. DEV. = -18.4 DEGREES
REMARK 500    LEU C 228   N   -  CA  -  CB  ANGL. DEV. =  41.6 DEGREES
REMARK 500    ARG C 482   CB  -  CA  -  C   ANGL. DEV. =  13.8 DEGREES
REMARK 500    HIS C 513   CA  -  CB  -  CG  ANGL. DEV. = -13.0 DEGREES
REMARK 500    ARG D 516   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.0 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    SER A 231     -168.74   -104.50
REMARK 500    GLU A 269     -150.87   -120.55
REMARK 500    ASP A 335     -126.98     61.43
REMARK 500    ASN A 359      -41.10     78.56
REMARK 500    PRO A 379       38.21    -85.00
REMARK 500    ASN A 400       88.18   -154.33
REMARK 500    HIS A 506        6.08     80.33
REMARK 500    HIS A 506        6.21     80.33
REMARK 500    HIS A 513       43.91    -91.45
REMARK 500    SER B 231     -166.26   -107.78
REMARK 500    GLU B 269     -146.44   -121.42
REMARK 500    ASP B 335     -132.45     59.64
REMARK 500    ASN B 359      -44.63     78.59
REMARK 500    ASN B 378       89.02   -154.62
REMARK 500    PRO B 379       37.71    -80.95
REMARK 500    HIS B 513       37.02    -97.85
REMARK 500    SER C 231     -166.87   -107.12
REMARK 500    GLU C 269     -145.70   -121.47
REMARK 500    ASP C 335     -134.52     65.17
REMARK 500    ASN C 359      -42.55     79.95
REMARK 500    PRO C 379       33.44    -89.49
REMARK 500    SER D 231     -167.74   -106.71
REMARK 500    GLU D 269     -139.93   -118.11
REMARK 500    ASP D 335     -134.75     63.88
REMARK 500    ASN D 359      -42.29     82.50
REMARK 500    ASN D 378       84.93   -160.46
REMARK 500    PRO D 379       25.96    -70.52
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS
REMARK 500
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.
REMARK 500                                 MODEL     OMEGA
REMARK 500 MET A  291     ASP A  292                  145.89
REMARK 500 MET B  291     ASP B  292                  142.60
REMARK 500 SER B  479     LEU B  480                 -148.88
REMARK 500 MET C  291     ASP C  292                  145.12
REMARK 500 MET D  291     ASP D  292                  142.11
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: PLANAR GROUPS
REMARK 500
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS
REMARK 500 AN RMSD GREATER THAN THIS VALUE
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500  M RES CSSEQI        RMS     TYPE
REMARK 500    ARG B 353         0.08    SIDE CHAIN
REMARK 500
REMARK 500 REMARK: NULL
REMARK 525
REMARK 525 SOLVENT
REMARK 525
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 525 NUMBER; I=INSERTION CODE):
REMARK 525
REMARK 525  M RES CSSEQI
REMARK 525    HOH A 915        DISTANCE =  6.34 ANGSTROMS
DBREF  8QMZ A  222   555  UNP    P34913   HYES_HUMAN     222    555
DBREF  8QMZ B  222   555  UNP    P34913   HYES_HUMAN     222    555
DBREF  8QMZ C  222   555  UNP    P34913   HYES_HUMAN     222    555
DBREF  8QMZ D  222   555  UNP    P34913   HYES_HUMAN     222    555
SEQADV 8QMZ MET A  198  UNP  P34913              INITIATING METHIONINE
SEQADV 8QMZ GLY A  199  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ SER A  200  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ SER A  201  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS A  202  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS A  203  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS A  204  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS A  205  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS A  206  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS A  207  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ SER A  208  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ SER A  209  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ GLY A  210  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ LEU A  211  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ VAL A  212  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ PRO A  213  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ ARG A  214  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ GLY A  215  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ SER A  216  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS A  217  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ MET A  218  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ ALA A  219  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ SER A  220  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ MET A  221  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ LEU A  556  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ LEU A  557  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ GLU A  558  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS A  559  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS A  560  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS A  561  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS A  562  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS A  563  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS A  564  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ MET B  198  UNP  P34913              INITIATING METHIONINE
SEQADV 8QMZ GLY B  199  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ SER B  200  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ SER B  201  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS B  202  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS B  203  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS B  204  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS B  205  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS B  206  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS B  207  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ SER B  208  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ SER B  209  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ GLY B  210  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ LEU B  211  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ VAL B  212  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ PRO B  213  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ ARG B  214  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ GLY B  215  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ SER B  216  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS B  217  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ MET B  218  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ ALA B  219  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ SER B  220  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ MET B  221  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ LEU B  556  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ LEU B  557  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ GLU B  558  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS B  559  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS B  560  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS B  561  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS B  562  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS B  563  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS B  564  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ MET C  198  UNP  P34913              INITIATING METHIONINE
SEQADV 8QMZ GLY C  199  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ SER C  200  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ SER C  201  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS C  202  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS C  203  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS C  204  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS C  205  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS C  206  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS C  207  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ SER C  208  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ SER C  209  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ GLY C  210  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ LEU C  211  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ VAL C  212  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ PRO C  213  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ ARG C  214  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ GLY C  215  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ SER C  216  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS C  217  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ MET C  218  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ ALA C  219  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ SER C  220  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ MET C  221  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ LEU C  556  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ LEU C  557  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ GLU C  558  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS C  559  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS C  560  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS C  561  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS C  562  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS C  563  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS C  564  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ MET D  198  UNP  P34913              INITIATING METHIONINE
SEQADV 8QMZ GLY D  199  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ SER D  200  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ SER D  201  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS D  202  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS D  203  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS D  204  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS D  205  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS D  206  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS D  207  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ SER D  208  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ SER D  209  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ GLY D  210  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ LEU D  211  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ VAL D  212  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ PRO D  213  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ ARG D  214  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ GLY D  215  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ SER D  216  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS D  217  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ MET D  218  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ ALA D  219  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ SER D  220  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ MET D  221  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ LEU D  556  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ LEU D  557  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ GLU D  558  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS D  559  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS D  560  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS D  561  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS D  562  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS D  563  UNP  P34913              EXPRESSION TAG
SEQADV 8QMZ HIS D  564  UNP  P34913              EXPRESSION TAG
SEQRES   1 A  367  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES   2 A  367  LEU VAL PRO ARG GLY SER HIS MET ALA SER MET LEU ASN
SEQRES   3 A  367  THR PRO ALA PRO LEU PRO THR SER CYS ASN PRO SER ASP
SEQRES   4 A  367  MET SER HIS GLY TYR VAL THR VAL LYS PRO ARG VAL ARG
SEQRES   5 A  367  LEU HIS PHE VAL GLU LEU GLY SER GLY PRO ALA VAL CYS
SEQRES   6 A  367  LEU CYS HIS GLY PHE PRO GLU SER TRP TYR SER TRP ARG
SEQRES   7 A  367  TYR GLN ILE PRO ALA LEU ALA GLN ALA GLY TYR ARG VAL
SEQRES   8 A  367  LEU ALA MET ASP MET LYS GLY TYR GLY GLU SER SER ALA
SEQRES   9 A  367  PRO PRO GLU ILE GLU GLU TYR CYS MET GLU VAL LEU CYS
SEQRES  10 A  367  LYS GLU MET VAL THR PHE LEU ASP LYS LEU GLY LEU SER
SEQRES  11 A  367  GLN ALA VAL PHE ILE GLY HIS ASP TRP GLY GLY MET LEU
SEQRES  12 A  367  VAL TRP TYR MET ALA LEU PHE TYR PRO GLU ARG VAL ARG
SEQRES  13 A  367  ALA VAL ALA SER LEU ASN THR PRO PHE ILE PRO ALA ASN
SEQRES  14 A  367  PRO ASN MET SER PRO LEU GLU SER ILE LYS ALA ASN PRO
SEQRES  15 A  367  VAL PHE ASP TYR GLN LEU TYR PHE GLN GLU PRO GLY VAL
SEQRES  16 A  367  ALA GLU ALA GLU LEU GLU GLN ASN LEU SER ARG THR PHE
SEQRES  17 A  367  LYS SER LEU PHE ARG ALA SER ASP GLU SER VAL LEU SER
SEQRES  18 A  367  MET HIS LYS VAL CYS GLU ALA GLY GLY LEU PHE VAL ASN
SEQRES  19 A  367  SER PRO GLU GLU PRO SER LEU SER ARG MET VAL THR GLU
SEQRES  20 A  367  GLU GLU ILE GLN PHE TYR VAL GLN GLN PHE LYS LYS SER
SEQRES  21 A  367  GLY PHE ARG GLY PRO LEU ASN TRP TYR ARG ASN MET GLU
SEQRES  22 A  367  ARG ASN TRP LYS TRP ALA CYS LYS SER LEU GLY ARG LYS
SEQRES  23 A  367  ILE LEU ILE PRO ALA LEU MET VAL THR ALA GLU LYS ASP
SEQRES  24 A  367  PHE VAL LEU VAL PRO GLN MET SER GLN HIS MET GLU ASP
SEQRES  25 A  367  TRP ILE PRO HIS LEU LYS ARG GLY HIS ILE GLU ASP CYS
SEQRES  26 A  367  GLY HIS TRP THR GLN MET ASP LYS PRO THR GLU VAL ASN
SEQRES  27 A  367  GLN ILE LEU ILE LYS TRP LEU ASP SER ASP ALA ARG ASN
SEQRES  28 A  367  PRO PRO VAL VAL SER LYS MET LEU LEU GLU HIS HIS HIS
SEQRES  29 A  367  HIS HIS HIS
SEQRES   1 B  367  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES   2 B  367  LEU VAL PRO ARG GLY SER HIS MET ALA SER MET LEU ASN
SEQRES   3 B  367  THR PRO ALA PRO LEU PRO THR SER CYS ASN PRO SER ASP
SEQRES   4 B  367  MET SER HIS GLY TYR VAL THR VAL LYS PRO ARG VAL ARG
SEQRES   5 B  367  LEU HIS PHE VAL GLU LEU GLY SER GLY PRO ALA VAL CYS
SEQRES   6 B  367  LEU CYS HIS GLY PHE PRO GLU SER TRP TYR SER TRP ARG
SEQRES   7 B  367  TYR GLN ILE PRO ALA LEU ALA GLN ALA GLY TYR ARG VAL
SEQRES   8 B  367  LEU ALA MET ASP MET LYS GLY TYR GLY GLU SER SER ALA
SEQRES   9 B  367  PRO PRO GLU ILE GLU GLU TYR CYS MET GLU VAL LEU CYS
SEQRES  10 B  367  LYS GLU MET VAL THR PHE LEU ASP LYS LEU GLY LEU SER
SEQRES  11 B  367  GLN ALA VAL PHE ILE GLY HIS ASP TRP GLY GLY MET LEU
SEQRES  12 B  367  VAL TRP TYR MET ALA LEU PHE TYR PRO GLU ARG VAL ARG
SEQRES  13 B  367  ALA VAL ALA SER LEU ASN THR PRO PHE ILE PRO ALA ASN
SEQRES  14 B  367  PRO ASN MET SER PRO LEU GLU SER ILE LYS ALA ASN PRO
SEQRES  15 B  367  VAL PHE ASP TYR GLN LEU TYR PHE GLN GLU PRO GLY VAL
SEQRES  16 B  367  ALA GLU ALA GLU LEU GLU GLN ASN LEU SER ARG THR PHE
SEQRES  17 B  367  LYS SER LEU PHE ARG ALA SER ASP GLU SER VAL LEU SER
SEQRES  18 B  367  MET HIS LYS VAL CYS GLU ALA GLY GLY LEU PHE VAL ASN
SEQRES  19 B  367  SER PRO GLU GLU PRO SER LEU SER ARG MET VAL THR GLU
SEQRES  20 B  367  GLU GLU ILE GLN PHE TYR VAL GLN GLN PHE LYS LYS SER
SEQRES  21 B  367  GLY PHE ARG GLY PRO LEU ASN TRP TYR ARG ASN MET GLU
SEQRES  22 B  367  ARG ASN TRP LYS TRP ALA CYS LYS SER LEU GLY ARG LYS
SEQRES  23 B  367  ILE LEU ILE PRO ALA LEU MET VAL THR ALA GLU LYS ASP
SEQRES  24 B  367  PHE VAL LEU VAL PRO GLN MET SER GLN HIS MET GLU ASP
SEQRES  25 B  367  TRP ILE PRO HIS LEU LYS ARG GLY HIS ILE GLU ASP CYS
SEQRES  26 B  367  GLY HIS TRP THR GLN MET ASP LYS PRO THR GLU VAL ASN
SEQRES  27 B  367  GLN ILE LEU ILE LYS TRP LEU ASP SER ASP ALA ARG ASN
SEQRES  28 B  367  PRO PRO VAL VAL SER LYS MET LEU LEU GLU HIS HIS HIS
SEQRES  29 B  367  HIS HIS HIS
SEQRES   1 C  367  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES   2 C  367  LEU VAL PRO ARG GLY SER HIS MET ALA SER MET LEU ASN
SEQRES   3 C  367  THR PRO ALA PRO LEU PRO THR SER CYS ASN PRO SER ASP
SEQRES   4 C  367  MET SER HIS GLY TYR VAL THR VAL LYS PRO ARG VAL ARG
SEQRES   5 C  367  LEU HIS PHE VAL GLU LEU GLY SER GLY PRO ALA VAL CYS
SEQRES   6 C  367  LEU CYS HIS GLY PHE PRO GLU SER TRP TYR SER TRP ARG
SEQRES   7 C  367  TYR GLN ILE PRO ALA LEU ALA GLN ALA GLY TYR ARG VAL
SEQRES   8 C  367  LEU ALA MET ASP MET LYS GLY TYR GLY GLU SER SER ALA
SEQRES   9 C  367  PRO PRO GLU ILE GLU GLU TYR CYS MET GLU VAL LEU CYS
SEQRES  10 C  367  LYS GLU MET VAL THR PHE LEU ASP LYS LEU GLY LEU SER
SEQRES  11 C  367  GLN ALA VAL PHE ILE GLY HIS ASP TRP GLY GLY MET LEU
SEQRES  12 C  367  VAL TRP TYR MET ALA LEU PHE TYR PRO GLU ARG VAL ARG
SEQRES  13 C  367  ALA VAL ALA SER LEU ASN THR PRO PHE ILE PRO ALA ASN
SEQRES  14 C  367  PRO ASN MET SER PRO LEU GLU SER ILE LYS ALA ASN PRO
SEQRES  15 C  367  VAL PHE ASP TYR GLN LEU TYR PHE GLN GLU PRO GLY VAL
SEQRES  16 C  367  ALA GLU ALA GLU LEU GLU GLN ASN LEU SER ARG THR PHE
SEQRES  17 C  367  LYS SER LEU PHE ARG ALA SER ASP GLU SER VAL LEU SER
SEQRES  18 C  367  MET HIS LYS VAL CYS GLU ALA GLY GLY LEU PHE VAL ASN
SEQRES  19 C  367  SER PRO GLU GLU PRO SER LEU SER ARG MET VAL THR GLU
SEQRES  20 C  367  GLU GLU ILE GLN PHE TYR VAL GLN GLN PHE LYS LYS SER
SEQRES  21 C  367  GLY PHE ARG GLY PRO LEU ASN TRP TYR ARG ASN MET GLU
SEQRES  22 C  367  ARG ASN TRP LYS TRP ALA CYS LYS SER LEU GLY ARG LYS
SEQRES  23 C  367  ILE LEU ILE PRO ALA LEU MET VAL THR ALA GLU LYS ASP
SEQRES  24 C  367  PHE VAL LEU VAL PRO GLN MET SER GLN HIS MET GLU ASP
SEQRES  25 C  367  TRP ILE PRO HIS LEU LYS ARG GLY HIS ILE GLU ASP CYS
SEQRES  26 C  367  GLY HIS TRP THR GLN MET ASP LYS PRO THR GLU VAL ASN
SEQRES  27 C  367  GLN ILE LEU ILE LYS TRP LEU ASP SER ASP ALA ARG ASN
SEQRES  28 C  367  PRO PRO VAL VAL SER LYS MET LEU LEU GLU HIS HIS HIS
SEQRES  29 C  367  HIS HIS HIS
SEQRES   1 D  367  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES   2 D  367  LEU VAL PRO ARG GLY SER HIS MET ALA SER MET LEU ASN
SEQRES   3 D  367  THR PRO ALA PRO LEU PRO THR SER CYS ASN PRO SER ASP
SEQRES   4 D  367  MET SER HIS GLY TYR VAL THR VAL LYS PRO ARG VAL ARG
SEQRES   5 D  367  LEU HIS PHE VAL GLU LEU GLY SER GLY PRO ALA VAL CYS
SEQRES   6 D  367  LEU CYS HIS GLY PHE PRO GLU SER TRP TYR SER TRP ARG
SEQRES   7 D  367  TYR GLN ILE PRO ALA LEU ALA GLN ALA GLY TYR ARG VAL
SEQRES   8 D  367  LEU ALA MET ASP MET LYS GLY TYR GLY GLU SER SER ALA
SEQRES   9 D  367  PRO PRO GLU ILE GLU GLU TYR CYS MET GLU VAL LEU CYS
SEQRES  10 D  367  LYS GLU MET VAL THR PHE LEU ASP LYS LEU GLY LEU SER
SEQRES  11 D  367  GLN ALA VAL PHE ILE GLY HIS ASP TRP GLY GLY MET LEU
SEQRES  12 D  367  VAL TRP TYR MET ALA LEU PHE TYR PRO GLU ARG VAL ARG
SEQRES  13 D  367  ALA VAL ALA SER LEU ASN THR PRO PHE ILE PRO ALA ASN
SEQRES  14 D  367  PRO ASN MET SER PRO LEU GLU SER ILE LYS ALA ASN PRO
SEQRES  15 D  367  VAL PHE ASP TYR GLN LEU TYR PHE GLN GLU PRO GLY VAL
SEQRES  16 D  367  ALA GLU ALA GLU LEU GLU GLN ASN LEU SER ARG THR PHE
SEQRES  17 D  367  LYS SER LEU PHE ARG ALA SER ASP GLU SER VAL LEU SER
SEQRES  18 D  367  MET HIS LYS VAL CYS GLU ALA GLY GLY LEU PHE VAL ASN
SEQRES  19 D  367  SER PRO GLU GLU PRO SER LEU SER ARG MET VAL THR GLU
SEQRES  20 D  367  GLU GLU ILE GLN PHE TYR VAL GLN GLN PHE LYS LYS SER
SEQRES  21 D  367  GLY PHE ARG GLY PRO LEU ASN TRP TYR ARG ASN MET GLU
SEQRES  22 D  367  ARG ASN TRP LYS TRP ALA CYS LYS SER LEU GLY ARG LYS
SEQRES  23 D  367  ILE LEU ILE PRO ALA LEU MET VAL THR ALA GLU LYS ASP
SEQRES  24 D  367  PHE VAL LEU VAL PRO GLN MET SER GLN HIS MET GLU ASP
SEQRES  25 D  367  TRP ILE PRO HIS LEU LYS ARG GLY HIS ILE GLU ASP CYS
SEQRES  26 D  367  GLY HIS TRP THR GLN MET ASP LYS PRO THR GLU VAL ASN
SEQRES  27 D  367  GLN ILE LEU ILE LYS TRP LEU ASP SER ASP ALA ARG ASN
SEQRES  28 D  367  PRO PRO VAL VAL SER LYS MET LEU LEU GLU HIS HIS HIS
SEQRES  29 D  367  HIS HIS HIS
HET    W6O  A 601      30
HET    EDO  A 602       4
HET    EDO  A 603       4
HET    EDO  A 604       4
HET    EDO  A 605       4
HET    W6O  B 601      30
HET    EDO  B 602       4
HET    EDO  B 603       4
HET    EDO  B 604       4
HET    EDO  B 605       4
HET    EDO  B 606       4
HET    W6O  C 601      30
HET    EDO  C 602       4
HET    EDO  C 603       4
HET    W6O  D 601      30
HET    EDO  D 602       4
HET    EDO  D 603       4
HET    EDO  D 604       4
HET    EDO  D 605       4
HET    EDO  D 606       4
HETNAM     W6O (3~{A}~{R},6~{A}~{S})-~{N}-[(2,4-DICHLOROPHENYL)
HETNAM   2 W6O  METHYL]-2-(4-METHYLPHENYL)SULFONYL-3,3~{A},4,5,6,
HETNAM   3 W6O  6~{A}-HEXAHYDRO-1~{H}-CYCLOPENTA[C]PYRROLE-5-
HETNAM   4 W6O  CARBOXAMIDE
HETNAM     EDO 1,2-ETHANEDIOL
HETSYN     EDO ETHYLENE GLYCOL
FORMUL   5  W6O    4(C22 H24 CL2 N2 O3 S)
FORMUL   6  EDO    16(C2 H6 O2)
FORMUL  25  HOH   *841(H2 O)
HELIX    1 AA1 ASN A  233  MET A  237  5                                   5
HELIX    2 AA2 SER A  270  ARG A  275  5                                   6
HELIX    3 AA3 TYR A  276  ALA A  284  1                                   9
HELIX    4 AA4 GLU A  304  TYR A  308  5                                   5
HELIX    5 AA5 CYS A  309  GLY A  325  1                                  17
HELIX    6 AA6 ASP A  335  TYR A  348  1                                  14
HELIX    7 AA7 SER A  370  ASN A  378  1                                   9
HELIX    8 AA8 PRO A  379  PHE A  381  5                                   3
HELIX    9 AA9 ASP A  382  PHE A  387  1                                   6
HELIX   10 AB1 GLY A  391  GLN A  399  1                                   9
HELIX   11 AB2 ASN A  400  PHE A  409  1                                  10
HELIX   12 AB3 ALA A  411  SER A  415  5                                   5
HELIX   13 AB4 SER A  418  HIS A  420  5                                   3
HELIX   14 AB5 LYS A  421  GLY A  426  1                                   6
HELIX   15 AB6 THR A  443  LYS A  456  1                                  14
HELIX   16 AB7 PHE A  459  TRP A  465  1                                   7
HELIX   17 AB8 ASN A  468  LYS A  478  1                                  11
HELIX   18 AB9 VAL A  500  GLN A  505  5                                   6
HELIX   19 AC1 HIS A  506  TRP A  510  5                                   5
HELIX   20 AC2 TRP A  525  LYS A  530  1                                   6
HELIX   21 AC3 LYS A  530  ALA A  546  1                                  17
HELIX   22 AC4 ASN B  233  MET B  237  5                                   5
HELIX   23 AC5 SER B  270  ARG B  275  5                                   6
HELIX   24 AC6 GLN B  277  ALA B  284  1                                   8
HELIX   25 AC7 GLU B  304  TYR B  308  5                                   5
HELIX   26 AC8 CYS B  309  GLY B  325  1                                  17
HELIX   27 AC9 ASP B  335  TYR B  348  1                                  14
HELIX   28 AD1 SER B  370  ASN B  378  1                                   9
HELIX   29 AD2 PRO B  379  PHE B  381  5                                   3
HELIX   30 AD3 ASP B  382  PHE B  387  1                                   6
HELIX   31 AD4 GLY B  391  ASN B  400  1                                  10
HELIX   32 AD5 ASN B  400  PHE B  409  1                                  10
HELIX   33 AD6 ALA B  411  SER B  415  5                                   5
HELIX   34 AD7 SER B  418  HIS B  420  5                                   3
HELIX   35 AD8 LYS B  421  GLY B  426  1                                   6
HELIX   36 AD9 THR B  443  GLY B  458  1                                  16
HELIX   37 AE1 PHE B  459  TRP B  465  1                                   7
HELIX   38 AE2 ASN B  468  LYS B  478  1                                  11
HELIX   39 AE3 VAL B  500  GLN B  505  5                                   6
HELIX   40 AE4 HIS B  506  TRP B  510  5                                   5
HELIX   41 AE5 TRP B  525  LYS B  530  1                                   6
HELIX   42 AE6 LYS B  530  ASP B  545  1                                  16
HELIX   43 AE7 ASN C  233  MET C  237  5                                   5
HELIX   44 AE8 SER C  270  ARG C  275  5                                   6
HELIX   45 AE9 TYR C  276  ALA C  284  1                                   9
HELIX   46 AF1 GLU C  304  TYR C  308  5                                   5
HELIX   47 AF2 CYS C  309  GLY C  325  1                                  17
HELIX   48 AF3 ASP C  335  TYR C  348  1                                  14
HELIX   49 AF4 SER C  370  ASN C  378  1                                   9
HELIX   50 AF5 PRO C  379  PHE C  381  5                                   3
HELIX   51 AF6 ASP C  382  PHE C  387  1                                   6
HELIX   52 AF7 GLY C  391  GLN C  399  1                                   9
HELIX   53 AF8 ASN C  400  PHE C  409  1                                  10
HELIX   54 AF9 ALA C  411  SER C  415  5                                   5
HELIX   55 AG1 SER C  418  HIS C  420  5                                   3
HELIX   56 AG2 LYS C  421  GLY C  426  1                                   6
HELIX   57 AG3 THR C  443  LYS C  455  1                                  13
HELIX   58 AG4 PHE C  459  TRP C  465  1                                   7
HELIX   59 AG5 ASN C  468  LYS C  478  1                                  11
HELIX   60 AG6 VAL C  500  GLN C  505  5                                   6
HELIX   61 AG7 HIS C  506  TRP C  510  5                                   5
HELIX   62 AG8 TRP C  525  LYS C  530  1                                   6
HELIX   63 AG9 LYS C  530  ALA C  546  1                                  17
HELIX   64 AH1 ASN D  233  MET D  237  5                                   5
HELIX   65 AH2 SER D  270  ARG D  275  5                                   6
HELIX   66 AH3 GLN D  277  ALA D  284  1                                   8
HELIX   67 AH4 GLU D  304  TYR D  308  5                                   5
HELIX   68 AH5 CYS D  309  GLY D  325  1                                  17
HELIX   69 AH6 ASP D  335  TYR D  348  1                                  14
HELIX   70 AH7 SER D  370  ASN D  378  1                                   9
HELIX   71 AH8 PRO D  379  PHE D  381  5                                   3
HELIX   72 AH9 ASP D  382  PHE D  387  1                                   6
HELIX   73 AI1 GLY D  391  GLN D  399  1                                   9
HELIX   74 AI2 ASN D  400  PHE D  409  1                                  10
HELIX   75 AI3 ALA D  411  SER D  415  5                                   5
HELIX   76 AI4 SER D  418  HIS D  420  5                                   3
HELIX   77 AI5 LYS D  421  GLY D  426  1                                   6
HELIX   78 AI6 THR D  443  LYS D  456  1                                  14
HELIX   79 AI7 PHE D  459  TRP D  465  1                                   7
HELIX   80 AI8 ASN D  468  LYS D  478  1                                  11
HELIX   81 AI9 VAL D  500  GLN D  505  5                                   6
HELIX   82 AJ1 HIS D  506  TRP D  510  5                                   5
HELIX   83 AJ2 TRP D  525  LYS D  530  1                                   6
HELIX   84 AJ3 LYS D  530  ALA D  546  1                                  17
SHEET    1 AA116 LEU A 514  ILE A 519  0
SHEET    2 AA116 ALA A 488  ALA A 493  1  N  ALA A 488   O  LYS A 515
SHEET    3 AA116 VAL A 352  LEU A 358  1  N  SER A 357   O  VAL A 491
SHEET    4 AA116 ALA A 329  HIS A 334  1  N  GLY A 333   O  LEU A 358
SHEET    5 AA116 ALA A 260  CYS A 264  1  N  CYS A 262   O  VAL A 330
SHEET    6 AA116 ARG A 287  MET A 291  1  O  LEU A 289   N  VAL A 261
SHEET    7 AA116 VAL A 248  LEU A 255 -1  N  LEU A 255   O  VAL A 288
SHEET    8 AA116 SER A 238  LYS A 245 -1  N  GLY A 240   O  PHE A 252
SHEET    9 AA116 SER C 238  LYS C 245 -1  O  TYR C 241   N  HIS A 239
SHEET   10 AA116 VAL C 248  LEU C 255 -1  O  PHE C 252   N  GLY C 240
SHEET   11 AA116 ARG C 287  MET C 291 -1  O  VAL C 288   N  LEU C 255
SHEET   12 AA116 ALA C 260  CYS C 264  1  N  VAL C 261   O  LEU C 289
SHEET   13 AA116 ALA C 329  HIS C 334  1  O  VAL C 330   N  CYS C 262
SHEET   14 AA116 VAL C 352  LEU C 358  1  O  LEU C 358   N  GLY C 333
SHEET   15 AA116 ALA C 488  ALA C 493  1  O  VAL C 491   N  SER C 357
SHEET   16 AA116 LEU C 514  ILE C 519  1  O  LYS C 515   N  ALA C 488
SHEET    1 AA216 LEU B 514  ILE B 519  0
SHEET    2 AA216 ALA B 488  ALA B 493  1  N  ALA B 488   O  LYS B 515
SHEET    3 AA216 VAL B 352  LEU B 358  1  N  SER B 357   O  VAL B 491
SHEET    4 AA216 ALA B 329  HIS B 334  1  N  GLY B 333   O  LEU B 358
SHEET    5 AA216 ALA B 260  CYS B 264  1  N  CYS B 262   O  VAL B 330
SHEET    6 AA216 ARG B 287  MET B 291  1  O  LEU B 289   N  VAL B 261
SHEET    7 AA216 VAL B 248  LEU B 255 -1  N  LEU B 255   O  VAL B 288
SHEET    8 AA216 SER B 238  LYS B 245 -1  N  GLY B 240   O  PHE B 252
SHEET    9 AA216 SER D 238  LYS D 245 -1  O  TYR D 241   N  HIS B 239
SHEET   10 AA216 VAL D 248  LEU D 255 -1  O  PHE D 252   N  GLY D 240
SHEET   11 AA216 ARG D 287  MET D 291 -1  O  VAL D 288   N  LEU D 255
SHEET   12 AA216 ALA D 260  CYS D 264  1  N  VAL D 261   O  LEU D 289
SHEET   13 AA216 ALA D 329  HIS D 334  1  O  VAL D 330   N  CYS D 262
SHEET   14 AA216 VAL D 352  LEU D 358  1  O  LEU D 358   N  GLY D 333
SHEET   15 AA216 ALA D 488  ALA D 493  1  O  VAL D 491   N  SER D 357
SHEET   16 AA216 LEU D 514  ILE D 519  1  O  ILE D 519   N  THR D 492
CISPEP   1 PHE A  267    PRO A  268          0       -12.05
CISPEP   2 PHE B  267    PRO B  268          0        -7.12
CISPEP   3 PHE C  267    PRO C  268          0       -13.21
CISPEP   4 PHE D  267    PRO D  268          0       -13.32
CRYST1   80.290   90.642  188.416  90.00  90.00  90.00 P 21 21 21   16
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.012455  0.000000  0.000000        0.00000
SCALE2      0.000000  0.011032  0.000000        0.00000
SCALE3      0.000000  0.000000  0.005307        0.00000
TER    2627      ARG A 547
TER    5268      ASP B 545
TER    7910      ARG C 547
TER   10546      ARG D 547
MASTER      630    0   20   84   32    0    0    611231    4  184  116
END